theophylline has been researched along with antipyrine in 101 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (55.45) | 18.7374 |
| 1990's | 22 (21.78) | 18.2507 |
| 2000's | 11 (10.89) | 29.6817 |
| 2010's | 11 (10.89) | 24.3611 |
| 2020's | 1 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Howard, SM; Scherrer, RA | 1 |
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Caron, G; Ermondi, G | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Corvaisier, S; Cresteil, T; Dallemagne, P; El Kihel, L; Jourdan, JP; Lecoutey, C; Legay, R; Malzert-Fréon, A; Rochais, C; Since, M; Sopkova-de Oliveira Santos, J | 1 |
| Brown, L; Horning, MG; Kellaway, P; Lertratanangkoon, K; Nowlin, J; Zion, TE | 1 |
| Alvares, AP; Anderson, KE; Conney, AH; Kappas, A; Kuntzman, R; Pantuck, EJ | 1 |
| Alvares, AP; Anderson, KE; Conney, AH; Kappas, A; Pantuck, EJ | 1 |
| Anderson, KE; Conney, AH; Kappas, A | 2 |
| Alvares, AP; Anderson, KE; Chang, R; Conney, AH; Kappas, A; Pantuck, CB; Pantuck, EJ | 1 |
| Kellermann, G; Luyten-Kellermann, M | 1 |
| Beubler, E; Lembeck, F | 1 |
| Kakac, B; Ryska, M; Sarsunova, M | 1 |
| Alvares, AP; Anderson, KE; Conney, AH; Kappas, A | 2 |
| Hori, R; Tanigawara, Y; Yano, I; Yasuhara, M | 1 |
| Aramayona, JJ; Barzago, MM; Bonati, M; Omarini, D | 1 |
| Bachmann, KA; Madhira, MS; Rankin, GO | 1 |
| Humphries, TJ | 1 |
| Bachmann, KA; Forney, RB; Jauregui, L; Martin, M; Nunlee, M; Schwartz, J | 1 |
| Adebayo, GI; Mabadeje, AF | 1 |
| Lønning, PE | 1 |
| Houston, JB; Matthew, DE | 2 |
| Gelboin, HV; Park, SS; Slusher, LB; Vesell, ES | 1 |
| Breimer, DD; Janssens, AR; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Acheson, DW; Braganza, JM; Houston, JB; Hunt, LP; Rose, P | 1 |
| Christensen, HR; Døssing, M; Evald, T; Lange, P | 1 |
| Eybl, V; Jones, MM; Kotyzová, D; Koutenský, J; Waitzová, D | 1 |
| Keup, W | 1 |
| Kvinssland, S; Lønning, PE; Ueland, PM | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 2 |
| Breimer, DD; Danhof, M; Schellens, JH; van der Velde, EA; van der Wart, JH | 1 |
| Abernethy, DR; Carrum, G; Dickinson, TH; Egan, JM | 1 |
| Acheson, DW; Braganza, JM; Brown, SW; Houston, JB; Uden, S | 1 |
| Denlinger, CL; Slusher, LB; Stryker, KK; Vesell, ES | 1 |
| Blyden, GT; Greenblatt, DJ; LeDuc, BW | 1 |
| Vesell, ES | 1 |
| André, P; Descotes, J; Evreux, JC | 1 |
| Berlinger, WG | 1 |
| Boeijinga, JK; Breimer, DD; De Leede, LG; Teunissen, MW | 1 |
| Birgersson, C; Ericsson, O; Göransson, M; Henthorn, T; Sjöqvist, F; Spina, E; von Bahr, C | 1 |
| Acheson, DW; Braganza, JM; Houston, JB; Rose, P | 1 |
| Sugimoto, I | 1 |
| Reiter, W | 1 |
| Naess, K | 1 |
| Kessler, H | 1 |
| Campiglio, A | 1 |
| Krause, M; Mährlein, W | 1 |
| Julich, H; Rücker, K | 1 |
| Stricker, H | 1 |
| Iven, A | 1 |
| Gürtler, J | 1 |
| Hansen, P | 1 |
| Hata, S; Sano, H; Tomioka, S; Yamakawa, M | 1 |
| Breen, KJ; Bury, R; Desmond, PV; Mashford, ML; Morphett, B; Shaw, RG; Westwood, B | 1 |
| Luczynska, C; Wilson, K | 1 |
| Bakke, OM; Kvinnsland, S; Lønning, E | 1 |
| Iwainsky, H; Kandt, D; Sehrt, I | 1 |
| Bertilsson, L; Birkett, DJ; Dahlqvist, R; Eichelbaum, M; Säwe, J; Sjöqvist, F | 1 |
| Amos, WH; Green, MD; Omaye, ST; Sauberlich, HE; Turnbull, JD | 1 |
| Anderson, KE; Buening, MK; Conney, AH; Fortner, JG; Kappas, A; Pantuck, CB; Pantuck, EJ | 1 |
| Grice, J; McGuffie, C; Petroff, V; Roberts, RK; Wood, L | 1 |
| Breimer, DD; Brouwer, A; Groen, K; Jansen, EJ; Schijff, G; van Bezooijen, CF | 1 |
| Gaylor, DW; Vesell, ES | 1 |
| Andres, FF; Bachmann, KA; Flynn, MG; Michaud, TJ; Rodriguez-Zayas, J; Sherman, GP | 1 |
| Bliesath, H; Hartmann, M; Huber, R; Radtke, HW; Steinijans, VW; Wurst, W; Zech, K | 1 |
| Blouin, RA; Hill, DB; Israel, BC; McClain, CJ; Shedlofsky, SI | 1 |
| Clark, CR; Ferry, DG; Kepple, M; Nyika, S; Wanwimolruk, S | 1 |
| Breimer, DD; Groen, K; Gulati, RS; Horan, MA; Jansen, EJ; Miljkovic, B; Paramsothy, V; Roberts, NA; van Bezooijen, CF | 1 |
| Bachmann, KA; Jauregui, L | 1 |
| Chakrabarti, A; Chandrashekhar, SM; Garg, SK | 1 |
| Breimer, DD; Groen, K | 1 |
| Blouin, RA; Israel, BC; McIntyre, W; Shedlofsky, SI | 1 |
| Blouin, RA; Israel, BC; Shedlofsky, SI; Tosheva, R | 1 |
| Bauman, JH; Fuentes, RJ | 1 |
| Kokue, E; Saitoh, T; Shimoda, M | 1 |
| REINHOLD, H; SAUERBREY, R | 1 |
| GOECHT, R | 1 |
| Boskovic, M; Injac, R; Karljikovic-Rajic, K; Prijatelj, M; Srdjenovic, B; Strukelj, B | 1 |
| Kataoka, M; Kokubo, H; Masaoka, Y; Ogura, R; Sakuma, S; Tanno, FK; Yamashita, S | 1 |
| Iwanaga, K; Kakemi, M; Kawai, M; Miyazaki, M | 1 |
| Ando, Y; Irie, T; Irikura, M; Ishitsuka, Y; Ito, S; Moriuchi, H; Somekawa-Kondo, T; Takahama, K; Tanaka, K; Yamaguchi, K; Yamazaki, T | 1 |
| Gharaibeh, SF; Jaradat, A; Obeidat, WM | 1 |
7 review(s) available for theophylline and antipyrine
| Article | Year |
|---|---|
Nutrition and chemical biotransformations in man.
Topics: Antipyrine; Charcoal; Diet; Dietary Carbohydrates; Dietary Proteins; Humans; Intestinal Mucosa; Meat; Pharmaceutical Preparations; Phenacetin; Theophylline; Vegetables | 1977 |
Regulation of drug metabolism in man by environmental factors.
Topics: Animals; Antipyrine; Cattle; Charcoal; Cooking; Dietary Carbohydrates; Dietary Proteins; Environment; Humans; Meat; Pharmaceutical Preparations; Phenacetin; Theophylline | 1979 |
Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole.
Topics: Aminopyrine; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Diazepam; Drug Interactions; Humans; Omeprazole; Phenytoin; Propranolol; Theophylline; Warfarin | 1991 |
Ethnic differences in reactions to drugs and xenobiotics. Nutrition as an environmental influence on chemical metabolism in man.
Topics: Animals; Antipyrine; Brassica; Cattle; Charcoal; Cooking; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Estradiol; Ethnicity; Male; Meat; Pharmaceutical Preparations; Phenacetin; Testosterone; Theophylline | 1986 |
Pharmacokinetic drug interactions with macrolide antibiotics.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antipyrine; Carbamazepine; Drug Interactions; Ergot Alkaloids; Erythromycin; Humans; Kinetics; Pharmaceutical Preparations; Theophylline; Troleandomycin | 1985 |
The clinical significance of the effects of cigarette smoking on drug disposition.
Topics: Acetaminophen; Antipyrine; Benzodiazepines; Chlorpromazine; Clomipramine; Codeine; Humans; Pharmaceutical Preparations; Phenacetin; Propranolol; Smoking; Theophylline; Warfarin | 1983 |
Lack of pantoprazole drug interactions in man.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin | 1994 |
7 trial(s) available for theophylline and antipyrine
| Article | Year |
|---|---|
Effect of nifedipine on antipyrine and theophylline disposition.
Topics: Adult; Antipyrine; Drug Interactions; Female; Humans; Male; Microsomes, Liver; Nifedipine; Premedication; Randomized Controlled Trials as Topic; Theophylline | 1990 |
Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease.
Topics: Adult; Aged; Alcohol Drinking; Antipyrine; Enzyme Induction; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Oxidation-Reduction; Pancreatic Diseases; Pancreatic Neoplasms; Pancreatitis; Smoking; Theophylline | 1989 |
Effect of theophylline and salbutamol on hepatic drug metabolism.
Topics: Adult; Albuterol; Antipyrine; Asthma; Coffee; Female; Humans; Liver; Male; Middle Aged; Respiratory Function Tests; Respiratory Tract Infections; Smoking; Theophylline | 1989 |
Lack of pantoprazole drug interactions in man.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Absorption; Antipyrine; Benzimidazoles; Contraceptives, Oral, Hormonal; Cross-Over Studies; Cytochrome P-450 Enzyme System; Diazepam; Digoxin; Drug Interactions; Female; Humans; Liver; Longitudinal Studies; Male; Nifedipine; Omeprazole; Pantoprazole; Phenytoin; Proton Pump Inhibitors; Sulfoxides; Theophylline; Tissue Distribution; Warfarin | 1994 |
Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP status in vivo.
Topics: Administration, Oral; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Ethosuximide; Humans; Liver; Lorazepam; Male; Oxidoreductases, N-Demethylating; Phenobarbital; Phenytoin; Quinidine; Rifampin; Smoking; Theophylline; Valproic Acid | 1993 |
Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients.
Topics: Aged; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Hexobarbital; Humans; Interferon-alpha; Liver; Male; Middle Aged; Neoplasms; Theophylline | 1993 |
Endotoxin depresses hepatic cytochrome P450-mediated drug metabolism in women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Area Under Curve; C-Reactive Protein; Cytochrome P-450 Enzyme System; Female; Fever; Hexobarbital; Humans; Hypnotics and Sedatives; Interleukin-6; Lipopolysaccharides; Liver; Middle Aged; Nephelometry and Turbidimetry; Phosphodiesterase Inhibitors; Regression Analysis; Theophylline; Tumor Necrosis Factor-alpha | 1997 |
88 other study(ies) available for theophylline and antipyrine
| Article | Year |
|---|---|
Use of distribution coefficients in quantitative structure-activity relationships.
Topics: Animals; Biological Transport, Active; Cell Membrane Permeability; Colon; Hydrogen-Ion Concentration; Intestinal Absorption; Lipid Metabolism; Oxidative Phosphorylation Coupling Factors; Rats; Regression Analysis; Structure-Activity Relationship | 1977 |
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzyl Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Humans; KB Cells; Models, Molecular; Molecular Structure; Protein Aggregates; Protein Binding; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Use of saliva in therapeutic drug monitoring.
Topics: Antipyrine; Caffeine; Ethosuximide; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Primidone; Saliva; Theophylline | 1977 |
Nutrition and oxidative drug metabolism in man: relative influence of dietary lipids, carbohydrate, and protein.
Topics: Adult; Antipyrine; Cholesterol; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Fats, Unsaturated; Female; Humans; Male; Theophylline; Triglycerides | 1979 |
Effect of charcoal-broiled beef on antipyrine and theophylline metabolism.
Topics: Adult; Antipyrine; Charcoal; Cooking; Half-Life; Humans; Male; Meat; Theophylline | 1978 |
Benzo(a)pyrene metabolism and plasma elimination rates of phenacetin, acetanilide and theophylline in man.
Topics: Acetanilides; Adolescent; Adult; Antipyrine; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Female; Half-Life; Humans; Lymphocyte Activation; Lymphocytes; Male; Mitogens; Phenacetin; Theophylline | 1978 |
Methylxanthines and intestinal drug absorption.
Topics: Animals; Antipyrine; Caffeine; Female; Intestinal Absorption; Jejunum; Male; Pharmaceutical Preparations; Rats; Regional Blood Flow; Salicylates; Theophylline; Tritium; Urea; Water | 1976 |
[Study on the effect of detection with iodine on the determination of aromatic compounds after their chromatographic separation, XII].
Topics: Aminopyrine; Antipyrine; Barbiturates; Caffeine; Chromatography, Thin Layer; Iodine; Mass Spectrometry; Theophylline | 1976 |
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man.
Topics: Adult; Antipyrine; Diet; Dietary Carbohydrates; Dietary Proteins; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline | 1976 |
Interactions between nutritional factors and drug biotransformations in man.
Topics: Adult; Antipyrine; Biotransformation; Dietary Carbohydrates; Dietary Proteins; Humans; Male; Mixed Function Oxygenases; Oxidoreductases; Theophylline | 1976 |
Effect of leukotriene C4 on theophylline disposition in guinea pigs.
Topics: Aminophylline; Animals; Antipyrine; Blood Gas Analysis; Bronchoconstriction; Chromatography, High Pressure Liquid; Guinea Pigs; Hematocrit; Likelihood Functions; Male; Protein Binding; Regression Analysis; SRS-A; Theophylline; Time Factors | 1992 |
In situ perfusion in the rabbit: effects of different umbilical flow rates on placental transfer of compounds.
Topics: Analysis of Variance; Animals; Antipyrine; Female; Kinetics; Maternal-Fetal Exchange; Perfusion; Pregnancy; Rabbits; Theophylline; Umbilical Arteries | 1992 |
The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances.
Topics: Animals; Antipyrine; Cobalt; Ethosuximide; Liver; Male; Mixed Function Oxygenases; Proadifen; Quinidine; Rats; Rats, Inbred Strains; Succinimides; Theophylline | 1992 |
The use of single sample clearance estimates to probe hepatic drug metabolism: handprinting the influence of cigarette smoking on human hepatic drug metabolism.
Topics: Antipyrine; Carbamazepine; Glucuronosyltransferase; Humans; Liver; Lorazepam; Male; Metabolic Clearance Rate; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmaceutical Preparations; Polycyclic Compounds; Quinidine; Smoking; Theophylline; Valproic Acid | 1990 |
Aminoglutethimide enzyme induction: pharmacological and endocrinological implications.
Topics: Aminoglutethimide; Antipyrine; Aromatase Inhibitors; Breast Neoplasms; Digitoxin; Drug Interactions; Estrogens; Humans; Theophylline; Warfarin | 1990 |
Drug metabolizing capacity in vitro and in vivo--I. Correlations between hepatic microsomal monooxygenase markers in beta-naphthoflavone-induced rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; In Vitro Techniques; Male; Microsomes, Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Theophylline | 1990 |
Drug metabolizing capacity in vitro and in vivo--II. Correlations between hepatic microsomal monooxygenase markers in phenobarbital-induced rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antipyrine; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide | 1990 |
Studies on the metabolism of aminopyrine, antipyrine and theophylline using monoclonal antibodies to cytochrome P-450 isozymes purified from rat liver.
Topics: Aminopyrine; Animals; Antibodies, Monoclonal; Antibody Specificity; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Activation; Epitopes; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Theophylline | 1987 |
Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach.
Topics: Adult; Aged; Antipyrine; Female; Hexobarbital; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Theophylline | 1989 |
The influence of some dithiocarbamates on oxidative drug metabolism: interaction with cadmium.
Topics: Animals; Antipyrine; Cadmium; Ditiocarb; Drug Interactions; Male; Mice; Mice, Inbred ICR; Pentobarbital; Theophylline; Thiocarbamates | 1987 |
Use, indications and distribution in different countries of the stimulant and hallucinogenic amphetamine derivatives under consideration by WHO.
Topics: Amphetamines; Antipyrine; Central Nervous System Stimulants; Diethylpropion; Hallucinogens; Humans; Phenylpropanolamine; Propylamines; Substance-Related Disorders; Theophylline; World Health Organization | 1986 |
Aminoglutethimide as an inducer of microsomal enzymes. Part 1: Pharmacological aspects.
Topics: Aminoglutethimide; Antipyrine; Dexamethasone; Digitoxin; Drug Interactions; Enzyme Activation; Humans; Kinetics; Medroxyprogesterone; Medroxyprogesterone Acetate; Microsomes; Theophylline; Warfarin | 1986 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. I.
Topics: Animals; Antipyrine; Liver; Male; Metabolic Clearance Rate; Mixed Function Oxygenases; Models, Biological; Pharmaceutical Preparations; Phenytoin; Rats; Rats, Inbred Strains; Theophylline; Valproic Acid; Warfarin | 1988 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach.
Topics: Adult; Antipyrine; Contraceptives, Oral; Female; Hexobarbital; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Regression Analysis; Sex Factors; Smoking; Theophylline | 1988 |
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil | 1988 |
Theophylline and antipyrine disposition in smoking and non-smoking epileptic subjects.
Topics: Adult; Antipyrine; Epilepsy; Female; Half-Life; Humans; Male; Middle Aged; Smoking; Theophylline | 1987 |
Studies on theophylline metabolism: autoinduction and inhibition by antipyrine.
Topics: Administration, Oral; Adult; Antipyrine; Drug Interactions; Humans; Male; Saliva; Theophylline | 1987 |
Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test.
Topics: Adult; Antipyrine; Asthma; Half-Life; Humans; Kinetics; Liver; Male; Theophylline | 1986 |
Polymorphisms of antipyrine and theophylline metabolism in man: molecular and clinical implications.
Topics: Administration, Oral; Adult; Antipyrine; Biotransformation; Female; Humans; Kinetics; Male; Middle Aged; Pedigree; Polymorphism, Genetic; Reference Values; Theophylline | 1986 |
The effect of dietary protein on drug clearance.
Topics: Antipyrine; Dietary Proteins; Humans; Kidney; Liver; Pharmaceutical Preparations; Theophylline | 1986 |
Correlation between antipyrine metabolite formation and theophylline metabolism in humans after simultaneous single-dose administration and at steady state.
Topics: Adult; Antipyrine; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Theophylline | 1985 |
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.
Topics: Amitriptyline; Antipyrine; Desipramine; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Metoprolol; Microsomes, Liver; Theophylline | 1985 |
Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause?
Topics: Adolescent; Adult; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Pancreatic Neoplasms; Pancreatitis; Theophylline | 1985 |
Studies on complexes. XIV. Effect of complex formation on drug absorption from alimentary tract. (5). Enhancing the absorption of certain drugs by complex formation.
Topics: Animals; Antipyrine; Caffeine; Indoles; Intestinal Absorption; Intestine, Small; Niacinamide; Rats; Salicylates; Theophylline | 1969 |
[Effect of non-aqueous elution agents on the behavior of extremely weak bases in ion exchange chromatography using an example of pharmaceutical agent mixture].
Topics: 1-Propanol; Antipyrine; Benzamides; Benzoates; Caffeine; Catechols; Central Nervous System Stimulants; Chromatography, Ion Exchange; Chromatography, Thin Layer; Ethanol; Methanol; Salicylamides; Solvents; Spectrophotometry; Tablets; Theophylline; Ultraviolet Rays; Water | 1969 |
[Combinated oral antiasthmatics--how effective are they? An invitation to discussion].
Topics: Administration, Oral; Antipyrine; Asthma; Caffeine; Drug Combinations; Ephedrine; Humans; Parasympatholytics; Theophylline | 1974 |
[Pediatric Asthma-Bisolvon suppositories in the treatment of asthmatic bronchitis and bronchial asthma in childhood].
Topics: Adolescent; Antipyrine; Asthma; Barbiturates; Benzyl Compounds; Bronchitis; Child; Child, Preschool; Drug Combinations; Ephedrine; Expectorants; Humans; Infant; Papaverine; Suppositories; Theophylline | 1972 |
[Determination of the N-methyl group in organic substances on the micro and decimomilligram scale].
Topics: Acetanilides; Aminopyrine; Antipyrine; Caffeine; Diphenhydramine; Ephedrine; Indicators and Reagents; Methylation; Microchemistry; Theobromine; Theophylline | 1973 |
[Modification of ventilation disturbances in chronic obstructive pulmonary emphysema by Pulmophylline].
Topics: Antipyrine; Chronic Disease; Humans; Male; Pulmonary Emphysema; Respiration; Theophylline | 1969 |
[Influence of Pulmophyllin on physical capacity in patients with pulmonary emphysema].
Topics: Adolescent; Adult; Aged; Antipyrine; Child; Female; Humans; Male; Middle Aged; Oxygen Consumption; Physical Fitness; Pulmonary Emphysema; Theophylline; Vital Capacity | 1969 |
[In vitro study of "availability of drugs. I. Resorption from the gastrointestinal tract].
Topics: Acetanilides; Acids; Alkaloids; Amino Alcohols; Aminopyrine; Analgesics; Aniline Compounds; Antipyrine; Aspirin; Barbiturates; Benzoates; Caprylates; Diffusion; Ephedrine; Gastric Juice; Indicators and Reagents; Intestinal Absorption; Models, Biological; Permeability; Phenols; Quinine; Salicylates; Sulfamerazine; Sulfamethazine; Sulfamethoxypyridazine; Sulfathiazoles; Sulfisomidine; Sulfonamides; Tetraethylammonium Compounds; Theophylline | 1970 |
[On drug therapy of emphysema and related diseases in more advanced age].
Topics: Aged; Antipyrine; Asthma; Atropa belladonna; Bronchitis; Bronchodilator Agents; Humans; Papaverine; Phytotherapy; Plants, Medicinal; Plants, Toxic; Pulmonary Emphysema; Theophylline | 1967 |
[Clinical and respiratory function technical studies of the new drug combination Asthmadyn-R in asthmatic clinical states].
Topics: Adult; Aged; Antipyrine; Asthma; Atropa belladonna; Bronchodilator Agents; Diphenhydramine; Ephedrine; Female; Humans; Male; Middle Aged; Phenethylamines; Phytotherapy; Plants, Medicinal; Plants, Toxic; Respiratory Function Tests; Spirometry; Theophylline | 1967 |
[Factory physician and bronchitis].
Topics: Antipyrine; Asthma; Atropa belladonna; Bronchitis; Humans; Occupational Medicine; Papaverine; Phytotherapy; Plant Extracts; Plants, Medicinal; Plants, Toxic; Pulmonary Emphysema; Theophylline | 1969 |
Quantum chemical considerations on the stability of aqueous solution of an electron acceptor such as menadione.
Topics: Antipyrine; Caffeine; Chemical Phenomena; Chemistry, Physical; Theophylline; Vitamin K | 1965 |
Effects of cimetidine and ranitidine on hepatic drug metabolism.
Topics: Adult; Antipyrine; Cimetidine; Drug Interactions; Female; Furans; Guanidines; Half-Life; Histamine H2 Antagonists; Humans; Liver; Male; Mixed Function Oxygenases; Ranitidine; Theophylline | 1982 |
Effect of aminoglutethimide on antipyrine, theophylline, and digitoxin disposition in breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Antipyrine; Breast Neoplasms; Chromatography, High Pressure Liquid; Digitoxin; Drug Interactions; Female; Humans; Kinetics; Male; Middle Aged; Theophylline | 1984 |
[Possibilities for optimizing therapy with theophylline preparations. III. Ventilatory effect and pharmacokinetics of "new" Pulmophyllin].
Topics: Adult; Aminophylline; Antipyrine; Asthma; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Humans; Kinetics; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Theophylline | 1984 |
Theophylline metabolism in relation to antipyrine, debrisoquine, and sparteine metabolism.
Topics: Adult; Antipyrine; Debrisoquin; Female; Humans; Isoquinolines; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Saliva; Smoking; Sparteine; Theophylline | 1984 |
Influence of ascorbic acid and erythorbic acid on drug metabolism in the cynomolgus monkey.
Topics: Animals; Antipyrine; Ascorbic Acid; Body Temperature; Drug Interactions; Food Additives; Haplorhini; Ketamine; Macaca fascicularis; Male; Pharmaceutical Preparations; Sleep; Stereoisomerism; Theophylline; Time Factors | 1980 |
Regulation of human drug metabolism by dietary factors.
Topics: Adult; Antipyrine; Biotransformation; Caffeine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Half-Life; Humans; Metabolic Clearance Rate; Oxidation-Reduction; Pharmaceutical Preparations; Theobromine; Theophylline; Vegetables | 1980 |
Cimetidine impairs the elimination of theophylline and antipyrine.
Topics: Adult; Antipyrine; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Kinetics; Male; Middle Aged; Theophylline | 1981 |
Influence of dietary protein and carbohydrate on oxidative biotransformation of drugs in normal adults and children with asthma.
Topics: Adolescent; Adult; Antipyrine; Asthma; Child; Dietary Carbohydrates; Dietary Proteins; Female; Humans; Male; Theophylline | 1981 |
The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Energy Intake; Female; Rats; Theophylline | 1995 |
Limitations of probit plots in pharmacogenetics: requirement of genetic analyses to test hypotheses based on graphical methods.
Topics: Antipyrine; Biometry; Genetic Techniques; Genetic Variation; Humans; Metabolic Clearance Rate; Pharmacogenetics; Theophylline | 1995 |
Exercise training does not alter cytochrome P-450 content and microsomal metabolism.
Topics: Animals; Antipyrine; Citrate (si)-Synthase; Cytochrome P-450 Enzyme System; Liver; Male; Metabolic Clearance Rate; Microsomes, Liver; Mixed Function Oxygenases; Muscle, Skeletal; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Sprague-Dawley; Running; Theophylline | 1994 |
Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism.
Topics: Administration, Oral; Adult; Antipyrine; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endotoxins; Hexobarbital; Humans; Interleukin-6; Lipopolysaccharides; Liver; Male; Metabolic Clearance Rate; Orosomucoid; Pharmacokinetics; Theophylline; Tumor Necrosis Factor-alpha | 1994 |
Effects of capsaicin on the pharmacokinetics of antipyrine, theophylline and quinine in rats.
Topics: Administration, Oral; Animals; Antipyrine; Capsaicin; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Quinine; Rats; Rats, Wistar; Theophylline | 1993 |
The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Chromatography, High Pressure Liquid; Female; Frail Elderly; Half-Life; Health Status; Humans; Theophylline | 1993 |
Pharmacokinetics of antipyrine and theophylline: unaltered by multi-dose omeprazole treatment in rabbits.
Topics: Animals; Antipyrine; Enzyme Inhibitors; Male; Omeprazole; Rabbits; Theophylline | 1995 |
Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Half-Life; Hexobarbital; Humans; Molecular Probes; Rats; Substrate Specificity; Theophylline | 1996 |
Cimetidine impairs the elimination of theophylline and antipyrine.
Topics: Antipyrine; Biotransformation; Bronchodilator Agents; Cimetidine; Drug Interactions; Enzyme Inhibitors; Humans; Theophylline | 1982 |
The impact of acute phase response on the plasma clearance of antipyrine, theophylline, phenytoin and nifedipine in rabbits.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyrine; Area Under Curve; Chromatography, High Pressure Liquid; Escherichia coli; Female; Half-Life; Injections, Intramuscular; Interleukin-6; Lipopolysaccharides; Metabolic Clearance Rate; Nifedipine; Phenytoin; Protein Binding; Rabbits; Theophylline; Vasodilator Agents | 2000 |
[On the use of pulmophylline in bronchial carcinoma].
Topics: Antipyrine; Carcinoma, Bronchogenic; Drug Combinations; Theophylline | 1960 |
[Experiences with Makara, a successful antiasthmatic power].
Topics: Anti-Asthmatic Agents; Antipyrine; Asthma; Ephedrine; Papaverine; Phenacetin; Theophylline | 1962 |
Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.
Topics: Acetaminophen; Antipyrine; Aspirin; Beverages; Biological Products; Caffeine; Chromatography, Micellar Electrokinetic Capillary; Codeine; Cosmetics; Food Analysis; Linear Models; Pharmaceutical Preparations; Salicylic Acid; Theobromine; Theophylline | 2008 |
Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.
Topics: Absorption; Acetaminophen; Animals; Antipyrine; Dosage Forms; Drug Carriers; Drug Delivery Systems; Drug Evaluation, Preclinical; Excipients; Hydrogen-Ion Concentration; Hypromellose Derivatives; Intestine, Small; Male; Methylcellulose; Permeability; Rats; Rats, Wistar; Solubility; Theophylline | 2009 |
Application of organogels as oral controlled release formulations of hydrophilic drugs.
Topics: Animals; Antipyrine; Delayed-Action Preparations; Drug Administration Routes; Gels; Hydrophobic and Hydrophilic Interactions; Ibuprofen; Male; Ofloxacin; Rats; Rats, Wistar; Solubility; Soybean Oil; Stearic Acids; Suspensions; Theophylline | 2012 |
Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
Topics: Aminophylline; Animals; Antipyrine; CA1 Region, Hippocampal; Creatine Kinase, BB Form; Disease Models, Animal; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavengers; Glutathione; Guinea Pigs; Hypoxia, Brain; Infusions, Intravenous; Lipid Peroxides; Male; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Phosphodiesterase Inhibitors; Phosphopyruvate Hydratase; Purinergic P1 Receptor Antagonists; Theophylline | 2013 |
The Influence of Drugs Solubilities and Chitosan-TPP Formulation Parameters on the Mean Hydrodynamic Diameters and Drugs Entrapment Efficiencies into Chitosan-TPP Nanoparticles.
Topics: Antipyrine; Ascorbic Acid; Chitosan; Drug Carriers; Hydrodynamics; Nanoparticles; Particle Size; Polymers; Propylthiouracil; Solubility; Theophylline | 2022 |