theophylline and 3-methylxanthine

theophylline has been researched along with 3-methylxanthine in 45 studies

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (46.67)	18.7374
1990's	11 (24.44)	18.2507
2000's	6 (13.33)	29.6817
2010's	6 (13.33)	24.3611
2020's	1 (2.22)	2.80

Authors

Authors	Studies
Hasegawa, T; Iwasaki, N; Kakiuchi, M; Kato, H; Konno, K; Miyamoto, K; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y	1
Daly, JW; Padgett, WL; Shamim, MT; Ukena, D	1
Daly, JW; Manning, M; Müller, CE; Shi, D	1
Cameron, IL; Lyles, MB; Rawls, HR	1
Fuhr, U; Roots, I; Rost, KL; Staib, AH	1
Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M	1
Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ	1
Berdel, D; Bonnacker, I; Süverkrüp, R; von Berg, A	1
Koup, JR; Rogge, MC; Sedman, AJ; Solomon, WR; Wagner, JG; Welling, PG	1
Birkett, DJ; Gregor, D; McManus, ME; Miners, JO; Stupans, I	1
Beck, R; Knoppert, DC; MacLeod, SM; Spino, M; Thiessen, JJ	1
Juan, D; Rammohan, M; Shin, SG	1
Rogge, MC; Sedman, AJ; Solomon, WR; Toothaker, RD; Wagner, JG; Welling, PG	1
Hafkenscheid, JC; Hekster, YA; Martea, M; Tiggeler, RG; Vree, TB	1
Beckmann, J; Elsässer, W; Gundert-Remy, U; Hertrampf, R	1
Levy, G; Ramzan, IM	1
Bompadre, S; Ercolani, P; Leone, L	1
du Souich, P; Hartemann, D; Saunier, C; Sautegeau, A	1
Chakraborty, J; Marks, V; Scott, NR	1
Gundert-Remy, U; Hildebrandt, R; Krüdewagen, B	1
Carney, JM; Holloway, FA; Modrow, HE	1
Berdel, D; Heimann, G	1
Nomura, T	1
Riegelman, S; Tang-Liu, DD; Williams, RL	1
Madsen, SM; Ribel, U	2
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR	1
Konishi, H; Morita, K; Yamaji, A	1
Iwaki, M; Ogiso, T; Okuyama, K; Tanino, T; Uno, S	1
Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K	1
Norman, A; Rodopoulos, N	1
Asoh, M; Kobayashi, S; Koitabashi, Y; Okano, YJ; Tateishi, T; Yamaguchi, A; Yoda, T	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Breaker, RR; Emilsson, GA; Soukup, GA	1
Desai, SK; Gallivan, JP	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Curran, CP; Dalton, TP; Derkenne, S; Dragin, N; Nebert, DW; Shertzer, HG	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Lee, SW; Pardi, A; Xia, T; Zhao, L	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Chen, XY; Liu, Y; Zhan, Y; Zhang, YF; Zhong, DF	1
Algharrawi, KH; Gopishetty, S; Subramanian, M; Summers, RM	1
Cho, JY; Choi, CW; Kim, BI; Kim, EK; Kim, HS; Lee, J; Lee, JA; Oh, J; Park, EA; Shin, SH; Sohn, JA; Yu, KS	1
Ma, C; Wang, H; Xia, T; Zhou, B	1
Li, X; Liu, X; Ma, C; Wu, T; Xia, T; Zheng, C; Zhou, B	1

Trials

3 trial(s) available for theophylline and 3-methylxanthine

Article	Year
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adolescent; Adult; Biotransformation; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cystic Fibrosis; Double-Blind Method; Humans; Male; Random Allocation; Theophylline; Uric Acid; Xanthines	1988
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children]. Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16 Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines	1984
Effect of fluconazole on theophylline disposition in humans. European journal of clinical pharmacology, 1994, Volume: 46, Issue:4 Topics: Adult; Cross-Over Studies; Enoxacin; Female; Fluconazole; Humans; Male; Metabolic Clearance Rate; Theophylline; Uric Acid; Xanthines	1994

Other Studies

42 other study(ies) available for theophylline and 3-methylxanthine

Article	Year
Effects of alkyl substitutions of xanthine skeleton on bronchodilation. Journal of medicinal chemistry, 1992, Oct-30, Volume: 35, Issue:22 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Animals; Bronchodilator Agents; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Organ Specificity; Receptors, Purinergic; Structure-Activity Relationship; Trachea; Xanthines	1992
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Adenylyl Cyclases; Adipose Tissue; Adrenal Gland Neoplasms; Animals; Blood Platelets; Brain; Caffeine; Chemical Phenomena; Chemistry; Humans; Molecular Structure; Phenylisopropyladenosine; Pheochromocytoma; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Tumor Cells, Cultured; Xanthines	1989
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines	1993
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Acridine Orange; Intercalating Agents; Methylation; Nonlinear Dynamics; Spectrophotometry; Structure-Activity Relationship; Xanthines	2001
Theophylline metabolism affected by mexiletine. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines	1992
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4 Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines	1990
Drug-drug interactions affecting fluoroquinolones. The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines	1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients. European journal of clinical pharmacology, 1989, Volume: 36, Issue:2 Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; Theophylline; Uric Acid; Urodynamics; Xanthines	1989
The theophylline-enoxacin interaction: II. Changes in the disposition of theophylline and its metabolites during intermittent administration of enoxacin. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Middle Aged; Theophylline; Time Factors; Xanthines	1989
Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Uric Acid; Xanthines	1988
Theophylline pharmacokinetics in normal elderly subjects. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theophylline; Uric Acid; Xanthines	1988
The theophylline-enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Theophylline; Uric Acid; Xanthines	1988
Pharmacokinetics of theophylline and its metabolites in a patient undergoing continuous ambulatory peritoneal dialysis. Clinical pharmacokinetics, 1988, Volume: 15, Issue:6 Topics: Aged; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Theophylline; Uric Acid; Xanthines	1988
Enoxacin--a potent inhibitor of theophylline metabolism. European journal of clinical pharmacology, 1987, Volume: 33, Issue:3 Topics: Adult; Anti-Infective Agents; Enoxacin; Humans; Naphthyridines; Theophylline; Uric Acid; Xanthines	1987
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Lew; Seizures; Theophylline; Uric Acid; Xanthines	1986
[Determination of theophylline in the plasma by rapid solid-phase extraction]. Bollettino della Societa italiana di biologia sperimentale, 1987, Aug-31, Volume: 63, Issue:8 Topics: Chromatography, High Pressure Liquid; Humans; Lung Diseases, Obstructive; Theophylline; Uric Acid; Xanthines	1987
Theophylline disposition during acute and chronic hypoxia in the conscious dog. Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:3 Topics: Acute Disease; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Dogs; Female; Hypoxia; Male; Theophylline; Uric Acid; Xanthines	1987
Urinary metabolites of caffeine in pregnant women. British journal of clinical pharmacology, 1986, Volume: 22, Issue:4 Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines	1986
Plasma concentrations of theophylline and its metabolites in a theophylline intoxicated child--reevaluation of published Km-values. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Hemoperfusion; Humans; Infant; Kinetics; Theophylline; Uric Acid; Xanthines	1986
Discriminative stimulus properties of methylxanthines and their metabolites in rats. Life sciences, 1985, Mar-11, Volume: 36, Issue:10 Topics: Animals; Caffeine; Discrimination Learning; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline; Xanthines	1985
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice. Cancer research, 1983, Volume: 43, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; Mice; Mice, Inbred ICR; Theobromine; Theophylline; Urethane; Xanthines	1983
Nonlinear theophylline elimination. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Administration, Oral; Adult; Aminophylline; Biotransformation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Models, Biological; Theophylline; Time Factors; Uric Acid; Xanthines	1982
Pharmacokinetics of theophylline and 3-methylxanthine in guinea pigs. I. Single dose administration. Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:1 Topics: Animals; Guinea Pigs; Injections, Intravenous; Kinetics; Male; Theophylline; Time Factors; Xanthines	1981
Pharmacokinetics of theophylline and 3-methylxanthine in guinea pigs. II. Multiple dose administration. Acta pharmacologica et toxicologica, 1981, Volume: 48, Issue:1 Topics: Animals; Guinea Pigs; Injections, Intraperitoneal; Injections, Intravenous; Kinetics; Male; Theophylline; Time Factors; Xanthines	1981
Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Epoxide Hydrolases; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Smoking; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthines	1995
Effect of mexiletine on elimination and metabolic conversion of theophylline and its major metabolites in rats. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2 Topics: Administration, Oral; Aminophylline; Animals; In Vitro Techniques; Injections, Intravenous; Liver; Male; Mexiletine; Rats; Rats, Wistar; Theophylline; Uric Acid; Xanthines	1993
Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6 Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Neurotoxins; Seizures; Theophylline; Uric Acid; Xanthines	1996
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients. Pediatric research, 1999, Volume: 45, Issue:1 Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Theophylline; Uric Acid; Xanthines	1999
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
Altering molecular recognition of RNA aptamers by allosteric selection. Journal of molecular biology, 2000, May-12, Volume: 298, Issue:4 Topics: Allosteric Regulation; Base Sequence; Binding Sites; Catalysis; Enzyme Activation; Genetic Engineering; Kinetics; Ligands; Models, Molecular; Mutation; Nucleic Acid Conformation; RNA, Catalytic; Structure-Activity Relationship; Substrate Specificity; Theophylline; Thermodynamics; Xanthines	2000
Genetic screens and selections for small molecules based on a synthetic riboswitch that activates protein translation. Journal of the American Chemical Society, 2004, Oct-20, Volume: 126, Issue:41 Topics: 5' Untranslated Regions; Caffeine; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Protein Biosynthesis; Ribosomes; RNA, Bacterial; RNA, Messenger; Theophylline; Xanthines	2004
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. Pharmacogenetics and genomics, 2005, Volume: 15, Issue:7 Topics: Animals; Area Under Curve; Blotting, Western; Body Weight; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Female; Gene Expression Regulation, Enzymologic; Half-Life; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polychlorinated Dibenzodioxins; Theophylline; Xanthines	2005
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Ultrafast dynamics show that the theophylline and 3-methylxanthine aptamers employ a conformational capture mechanism for binding their ligands. Biochemistry, 2010, Apr-06, Volume: 49, Issue:13 Topics: Anisotropy; Aptamers, Nucleotide; Kinetics; Nucleic Acid Conformation; Spectrometry, Fluorescence; Theophylline; Xanthines	2010
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
[Quantitative analysis of theophylline and its metabolites in urine of Chinese healthy subjects after oral administration of theophylline sustained-release tablets]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:7 Topics: Administration, Oral; Asian People; Calibration; Chromatography, Liquid; Delayed-Action Preparations; Healthy Volunteers; Humans; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2014
Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microbial cell factories, 2015, Dec-21, Volume: 14 Topics: Escherichia coli; Metabolic Engineering; Theophylline; Xanthines	2015
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. British journal of clinical pharmacology, 2017, Volume: 83, Issue:6 Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Theophylline; Uric Acid; Xanthines	2017
Biodegradation of caffeine by whole cells of tea-derived fungi Aspergillus sydowii, Aspergillus niger and optimization for caffeine degradation. BMC microbiology, 2018, 06-05, Volume: 18, Issue:1 Topics: Aspergillus; Aspergillus niger; Biodegradation, Environmental; Caffeine; Fermentation; Substrate Specificity; Tea; Theophylline; Xanthines	2018
Isolation, characterization and application of theophylline-degrading Aspergillus fungi. Microbial cell factories, 2020, Mar-19, Volume: 19, Issue:1 Topics: Aspergillus; Biotransformation; Fermentation; Theophylline; Xanthine; Xanthines	2020