theophylline and 1-methyluric acid

theophylline has been researched along with 1-methyluric acid in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (41.30)	18.7374
1990's	15 (32.61)	18.2507
2000's	6 (13.04)	29.6817
2010's	6 (13.04)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bearne, SL; Lunn, FA; Roy, AC	1
Fuhr, U; Roots, I; Rost, KL; Staib, AH	1
Birkett, DJ; Day, RO; Miners, JO	1
Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K; Yoshizumi, H	1
Beitins, IZ; Kilbane, AJ; Manis, M; Silbart, LK; Weber, WW	1
Advenier, C; Beaumont, D; Brion, N; Naline, E; Pays, M	1
Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ	1
Hori, R; Kishimoto, I; Okumura, K; Tanigawara, Y	1
Berdel, D; Bonnacker, I; Süverkrüp, R; von Berg, A	1
Beck, R; Knoppert, DC; MacLeod, SM; Spino, M; Thiessen, JJ	1
Juan, D; Rammohan, M; Shin, SG	1
Rogge, MC; Sedman, AJ; Solomon, WR; Toothaker, RD; Wagner, JG; Welling, PG	1
Hafkenscheid, JC; Hekster, YA; Martea, M; Tiggeler, RG; Vree, TB	1
Beckmann, J; Elsässer, W; Gundert-Remy, U; Hertrampf, R	1
Levy, G; Ramzan, IM	1
Bompadre, S; Ercolani, P; Leone, L	1
Chakraborty, J; Marks, V; Scott, NR	1
Berdel, D; Heimann, G	1
Gundert-Remy, U; Hildebrandt, R; Möller, H; Weber, E	1
Attwood, J; Birkett, DJ; Miners, JO	1
Hemsworth, TC; Renton, KW	1
Riegelman, S; Tang-Liu, DD; Williams, RL	1
Birkett, DJ; Grygiel, JJ	1
Jonkman, JH; Riegelman, S; Tang, D; Upton, RA	1
Jang, IJ; Kim, SW; Lee, KH; Lee, SH; Lee, SW; Oh, SJ; Shin, SG; Yim, DS	1
Konishi, H; Morita, K; Yamaji, A	1
Galteau, MM; Gueguen, R; Pontes, ZB; Siest, G; Vincent-Viry, M	1
Iwaki, M; Ogiso, T; Okuyama, K; Tanino, T; Uno, S	1
Norman, A; Rodopoulos, N	1
Asoh, M; Kobayashi, S; Koitabashi, Y; Okano, YJ; Tateishi, T; Yamaguchi, A; Yoda, T	1
Bernal, ML; Fanlo, A; Juste, JL; Lanuza, J; Mayayo, E; Sáenz, MA; Sinués, B	1
Kuh, HJ; Shim, CK	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Cao, XM; Ling, SS; Lu, JF; Yi, T; Zhuo, HT	1
Cao, XM; Lin, SS; Lu, JF; Yi, T; Zhuo, HT	1
Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Li, J; Peng, XQ; Xu, JP; Zhang, J	1
Asprodini, EK; Begas, E; Kouvaras, E; Papakosta, S; Tsakalof, A	1
Hasegawa, T; Kato, M; Kimura, M; Nadai, M; Tsunekawa, Y; Ueyama, J; Yasui, K; Yoshizumi, H; Zhao, YL	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Fan, XR; Li, XY; Li, YF; Li, YP; Liu, YN; Yang, M; Yao, XC; Yin, YM; Yuan, M; Zhu, JB	1
Chen, XY; Liu, Y; Zhan, Y; Zhang, YF; Zhong, DF	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Cho, JY; Choi, CW; Kim, BI; Kim, EK; Kim, HS; Lee, J; Lee, JA; Oh, J; Park, EA; Shin, SH; Sohn, JA; Yu, KS	1

Trials

3 trial(s) available for theophylline and 1-methyluric acid

Article	Year
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adolescent; Adult; Biotransformation; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cystic Fibrosis; Double-Blind Method; Humans; Male; Random Allocation; Theophylline; Uric Acid; Xanthines	1988
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children]. Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16 Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines	1984
Effect of fluconazole on theophylline disposition in humans. European journal of clinical pharmacology, 1994, Volume: 46, Issue:4 Topics: Adult; Cross-Over Studies; Enoxacin; Female; Fluconazole; Humans; Male; Metabolic Clearance Rate; Theophylline; Uric Acid; Xanthines	1994

Other Studies

43 other study(ies) available for theophylline and 1-methyluric acid

Article	Year
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines	2010
Theophylline metabolism affected by mexiletine. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:1 Topics: Adult; Caffeine; Humans; Male; Mexiletine; Theophylline; Uric Acid; Xanthines	1992
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect. British journal of clinical pharmacology, 1991, Volume: 32, Issue:2 Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines	1991
Effects of enoxacin on renal and metabolic clearance of theophylline in rats. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:9 Topics: Animals; Enoxacin; Kidney; Male; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1990
Human N-acetylation genotype determination with urinary caffeine metabolites. Clinical pharmacology and therapeutics, 1990, Volume: 47, Issue:4 Topics: Acetylation; Caffeine; Chromatography, High Pressure Liquid; Gene Frequency; Genetics, Population; Genotype; Humans; Nitrogen; Pedigree; Phenotype; Theophylline; Time Factors; Uracil; Uric Acid; Xanthines	1990
Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects. British journal of clinical pharmacology, 1989, Volume: 27, Issue:3 Topics: Adult; Benzhydryl Compounds; Drug Interactions; Humans; Male; Terfenadine; Theophylline; Time Factors; Uric Acid; Xanthines	1989
Drug-drug interactions affecting fluoroquinolones. The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines	1989
Blood oxygen tension-related change of theophylline clearance in experimental hypoxemia. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Hypoxia; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients. European journal of clinical pharmacology, 1989, Volume: 36, Issue:2 Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; Theophylline; Uric Acid; Urodynamics; Xanthines	1989
Theophylline pharmacokinetics in normal elderly subjects. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theophylline; Uric Acid; Xanthines	1988
The theophylline-enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Theophylline; Uric Acid; Xanthines	1988
Pharmacokinetics of theophylline and its metabolites in a patient undergoing continuous ambulatory peritoneal dialysis. Clinical pharmacokinetics, 1988, Volume: 15, Issue:6 Topics: Aged; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Theophylline; Uric Acid; Xanthines	1988
Enoxacin--a potent inhibitor of theophylline metabolism. European journal of clinical pharmacology, 1987, Volume: 33, Issue:3 Topics: Adult; Anti-Infective Agents; Enoxacin; Humans; Naphthyridines; Theophylline; Uric Acid; Xanthines	1987
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Lew; Seizures; Theophylline; Uric Acid; Xanthines	1986
[Determination of theophylline in the plasma by rapid solid-phase extraction]. Bollettino della Societa italiana di biologia sperimentale, 1987, Aug-31, Volume: 63, Issue:8 Topics: Chromatography, High Pressure Liquid; Humans; Lung Diseases, Obstructive; Theophylline; Uric Acid; Xanthines	1987
Urinary metabolites of caffeine in pregnant women. British journal of clinical pharmacology, 1986, Volume: 22, Issue:4 Topics: Caffeine; Female; Humans; Pregnancy; Theophylline; Uric Acid; Xanthines	1986
Lack of clinically important interaction between erythromycin and theophylline. European journal of clinical pharmacology, 1984, Volume: 26, Issue:4 Topics: Adult; Drug Interactions; Erythromycin; Female; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Kinetics; Male; Theophylline; Uric Acid; Xanthines	1984
Secondary metabolism of theophylline biotransformation products in man--route of formation of 1-methyluric acid. British journal of clinical pharmacology, 1983, Volume: 15, Issue:1 Topics: Biotransformation; Humans; Male; Theophylline; Uric Acid; Xanthines	1983
Depression of theophylline metabolism and elimination by troleandomycin and erythromycin. Biochemical pharmacology, 1981, Jun-01, Volume: 30, Issue:11 Topics: Animals; Drug Interactions; Erythromycin; In Vitro Techniques; Male; Metabolic Clearance Rate; Microsomes, Liver; Rabbits; Theophylline; Troleandomycin; Uric Acid	1981
Nonlinear theophylline elimination. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Administration, Oral; Adult; Aminophylline; Biotransformation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Models, Biological; Theophylline; Time Factors; Uric Acid; Xanthines	1982
Cigarette smoking and theophylline clearance and metabolism. Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:4 Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Smoking; Theophylline; Uric Acid; Xanthines	1981
Measurement of excretion characteristics of theophylline and its major metabolites. European journal of clinical pharmacology, 1981, Volume: 20, Issue:6 Topics: Humans; Kinetics; Theophylline; Uric Acid; Xanthines	1981
CYP1A2 activity as a risk factor for bladder cancer. Journal of Korean medical science, 1994, Volume: 9, Issue:6 Topics: Acetylation; Adult; Aged; Amines; Carcinoma, Transitional Cell; Case-Control Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Disease Susceptibility; Enzyme Induction; Female; Humans; Isoniazid; Korea; Logistic Models; Male; Methylation; Metoprolol; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Smoking; Theophylline; Uric Acid; Urinary Bladder Neoplasms	1994
Segregation analyses of four urinary caffeine metabolite ratios implicated in the determination of human acetylation phenotypes. Genetic epidemiology, 1994, Volume: 11, Issue:2 Topics: Acetylation; Adolescent; Adult; Alleles; Arylamine N-Acetyltransferase; Caffeine; Child; Chromatography, High Pressure Liquid; Family; Female; Gene Frequency; Genes, Recessive; Humans; Male; Middle Aged; Models, Genetic; Models, Statistical; Phenotype; Polymorphism, Genetic; Theophylline; Uracil; Uric Acid; Xanthines	1994
Effect of mexiletine on elimination and metabolic conversion of theophylline and its major metabolites in rats. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2 Topics: Administration, Oral; Aminophylline; Animals; In Vitro Techniques; Injections, Intravenous; Liver; Male; Mexiletine; Rats; Rats, Wistar; Theophylline; Uric Acid; Xanthines	1993
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients. Pediatric research, 1999, Volume: 45, Issue:1 Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Theophylline; Uric Acid; Xanthines	1999
Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:2 Topics: Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Environmental Exposure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mutagens; Rheology; Smoking; Theophylline; Time Factors; Uracil; Uric Acid; Urination; Xanthines	1999
Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. Archives of pharmacal research, 1994, Volume: 17, Issue:2 Topics: Animals; Biotransformation; Bronchodilator Agents; Infusions, Intravenous; Injections, Intravenous; Male; Nonlinear Dynamics; Probenecid; Rats; Rats, Wistar; Renal Agents; Theophylline; Uric Acid	1994
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:11 Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	1997
[HPLC determination of five caffeine metabolites]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:8 Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Theophylline; Uracil; Uric Acid; Xanthines	1997
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2 Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines	2002
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2A6; Female; Humans; Male; Mixed Function Oxygenases; Theophylline; Uracil; Uric Acid; Xanthines	2006
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios. Biomedical chromatography : BMC, 2007, Volume: 21, Issue:2 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines	2007
Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3 Topics: Acyclovir; Animals; Antiviral Agents; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Theophylline; Uric Acid; Vasodilator Agents; Xanthines	2007
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
[Effect of Tibetan medicine zuotai on the activity, protein and mRNA expression of CYP1A2 and NAT2]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:2 Topics: Administration, Oral; Animals; Arylamine N-Acetyltransferase; Caffeine; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Male; Medicine, Tibetan Traditional; Rats; Rats, Sprague-Dawley; RNA, Messenger; Theophylline; Uracil; Uric Acid; Xanthines	2014
[Quantitative analysis of theophylline and its metabolites in urine of Chinese healthy subjects after oral administration of theophylline sustained-release tablets]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:7 Topics: Administration, Oral; Asian People; Calibration; Chromatography, Liquid; Delayed-Action Preparations; Healthy Volunteers; Humans; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. British journal of clinical pharmacology, 2017, Volume: 83, Issue:6 Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Theophylline; Uric Acid; Xanthines	2017