theophylline has been researched along with 1-methyl-3-isobutylxanthine in 466 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 361 (77.47) | 18.7374 |
| 1990's | 82 (17.60) | 18.2507 |
| 2000's | 19 (4.08) | 29.6817 |
| 2010's | 4 (0.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bridson, PK; Daly, JW; Hide, I | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Bruns, RF; Christ, WJ; Ibay, AC; Schneller, SW | 1 |
| Bristol, JA; Cain, MH; Weishaar, RE | 1 |
| Daly, JW; Padgett, WL; Shamim, MT | 1 |
| Egle, JL; El-Said, MK; Glennon, RA; Rogers, ME; Smith, JD | 1 |
| Daly, JW | 1 |
| Bertin, B; Freissmuth, M; Hohenegger, M; Jockers, R; Linder, ME; Marullo, S; Nanoff, C; Strosberg, AD | 1 |
| Daly, JW; Manning, M; Müller, CE; Shi, D | 1 |
| Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Kiriasis, L; Manning, M; Müller, C; Neumeyer, JL; Pfleiderer, W; Shi, D | 1 |
| Borea, PA; Dalpiaz, A; Gilli, G; Gilli, P; Scatturin, A; Varani, K | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bucki, A; Chłoń-Rzepa, G; Gawalska, A; Jankowska, A; Kołaczkowski, M; Pawłowski, M; Pociecha, K; Ślusarczyk, M; Świerczek, A; Wyska, E | 1 |
| Birnbaumer, L; Entman, ML; Garber, AJ | 1 |
| Loizzi, RF | 1 |
| Channing, CP; Lindsey, AM | 1 |
| Grotjan, HE; Heindel, JJ; Steinberger, E | 1 |
| Franchi-Micheli, S; Rosselli, P; Zilletti, L | 1 |
| Bennett, T; Strange, PG | 1 |
| Brooker, G; Nickols, GA | 1 |
| Chernick, SS; Garrison, MM; Scow, RO; Spooner, PM | 1 |
| Gledhill, RM | 1 |
| Brackett, NL; Helfman, DM; Kuo, JF; Shoji, M | 1 |
| Fawcett, CP; McCann, SM; Naor, Z; Snyder, G | 1 |
| Cannon, JG; Frohman, LA; Kovathana, N; Payne, P; Rick, J; Szabo, M | 1 |
| Makman, MH; Wilkening, D | 1 |
| Anderson, WH; Fitzpatrick, DF; Hwang, DP; Krzanowski, JJ; Polson, JB; Szentivanyi, A | 1 |
| Lehnert, S | 2 |
| Goz, B; Wharton, W | 2 |
| Brown, BS; Krzanowski, JJ; Polson, JB | 1 |
| Mizutani, A; Sugimura, K | 1 |
| Losier, AJ; YoungLai, EV | 1 |
| Gylfe, E; Hahn, HJ; Hellman, B | 1 |
| Bertram, JS | 1 |
| Schimmel, RJ | 2 |
| Garcia, L; Rogers, BJ | 1 |
| Adolfs, MJ; Bonta, IL; Parnham, MJ | 1 |
| Soll, AH; Wollin, A | 1 |
| Duggan, AW; Griersmith, BT | 1 |
| Corson, DW; Fein, A; Schmidt, J | 1 |
| Fein, A; Schmidt, JA | 1 |
| Dembinska-Kiec, A; Rücker, W; Schönhöfer, PS | 1 |
| Russell, TR | 1 |
| Edstrom, JP; Kirkpatrick, JR; Kostopoulos, GK; Phillis, JW | 1 |
| Daly, JW; Smellie, FW; Wells, JN | 1 |
| Burchiel, SW; Melmon, KL | 1 |
| Jolicoeur, FB; Menard, D | 1 |
| Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S | 1 |
| Gauthier, C; Le Bec, A; Lugnier, C; Soustre, H | 1 |
| Bang, YJ; Danielpour, D; Kim, KY; Kim, SJ; Myers, CE; O'Reilly, MA; Trepel, JB | 1 |
| Bachelet, M; Hatmi, M; Havet, N; Vargaftig, BB | 1 |
| Suzuki, R; Yoshino, H | 1 |
| Rivedal, E; Roseng, LE; Sanner, T | 1 |
| Gallemore, RP; Nao-i, N; Steinberg, RH | 1 |
| Argyriou, S; Bordun, AM; Hamilton, JA; Vairo, G; Whitty, G | 1 |
| Howell, RE; Kinnier, WJ; Muehsam, WT | 1 |
| Endoh, M; Katano, Y | 1 |
| Mante, S; Minneman, KP | 1 |
| de Belleroche, J; Gardiner, IM | 1 |
| Ajiro, K; Nishikawa, Y; Shibata, K | 1 |
| Donaldson, J; Hall, IP; Hill, SJ | 1 |
| Lomri, A; Marie, PJ | 1 |
| Chilton, FH; Goldman, D; Torphy, TJ; Undem, BJ | 1 |
| Cornish, J; Gray, DH; Lowe, C; Reid, IR; Skinner, SJ | 1 |
| Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD | 1 |
| Fernandez-Gallardo, S; Garcia, C; Garcia, MC; Gijon, MA; Nieto, ML; Sanchez Crespo, M | 1 |
| Bali, JP; Choquet, A; Leonard, A; Magous, R | 1 |
| Takuma, T | 1 |
| Ago, JM; Dewhirst, FE; Stashenko, P | 1 |
| Melitto, C; Ortíz, CE; Romero, PJ | 1 |
| Alexander, B; Mathie, RT | 1 |
| Canalis, E; Centrella, M; McCarthy, TL | 1 |
| Löffler, G; Pöll-Jordan, G; Schmidt, W | 1 |
| Fukuda, A; Minami, T; Nabekura, J; Oomura, Y | 1 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Gellert, M; Menetski, JP | 1 |
| Chuo, S; Ferrar, RS; Greeley, GH; Hill, FL; Jeng, YJ; Kern, K; Nagasawa, S; Thompson, JC; Townsend, CM; Yanaihara, N | 1 |
| Moreno, S; Tomes, C | 1 |
| Bemis, KG; Fleisch, JH; Henry, DP; Marshall, WS; Rinkema, LE; Roman, CR; Russell, WL; Spaethe, SM | 1 |
| Abraham, RT; Abu-Ghazaleh, RI; Gleich, GJ; Kita, H | 1 |
| Belan, PV; Kostyuk, PG; Tepikin, AV | 1 |
| Canonico, PL; Catania, MV; Nicoletti, F; Rampello, L; Sortino, MA | 1 |
| Luk'ianets, EA | 1 |
| Bethke, T; Mehl, H; Meyer, W; Schmitz, W; Scholz, H; Thomas, K; Wenzlaff, H | 1 |
| Sato-Bigbee, C; Yu, RK | 1 |
| Asztalos, Z; Friedrich, P; Lossos, M | 1 |
| Sadler, SE | 1 |
| Churchill, PC; Wu, PH | 1 |
| Kitos, TE; Michaelis, ML; Mooney, T | 1 |
| Kafengauz, BIu; Poskonova, MA | 1 |
| Brückner, R; Gramann, S; Nose, M; Schmitz, W; Scholz, H | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Gerber, JG; Nies, AS; Payne, NA | 1 |
| Sawynok, J; Steardo, L | 1 |
| Morse, DE; Ness, JC | 1 |
| de Koning, J; Jenner, AA; Tijssen, AM; van Rees, GP | 1 |
| Armstrong, WM; Corcia, A; Zeldin, DC | 1 |
| Cuthbert, AW; Hickman, ME | 1 |
| Dirksen, ER; Sanderson, MJ; Satir, P | 1 |
| Elks, ML; Manganiello, VC | 1 |
| Anand-Srivastava, MB; Cantin, M; Gutkowska, J | 1 |
| Bisschop, A; Derks, HJ; van Rooijen, LA; van Wijk, R | 1 |
| Lazdunski, M; Renaud, JF; Schmid, A | 1 |
| Hoskins, DD; Vijayaraghavan, S | 2 |
| Kopf, GS; Vacquier, VD | 1 |
| Francis, SH | 1 |
| Moore, SJ; Schiff, LJ | 1 |
| Coffin, VL; Spealman, RD | 2 |
| Meyer, W; Scholz, H | 1 |
| Gabbay, RA; Lardy, HA | 1 |
| Braun, W; Reymann, A; Woermann, C | 1 |
| Livingston, A; Morris, B | 1 |
| Church, MK; Hughes, PJ; Vardey, CJ | 1 |
| Butcher, RW; Clark, RB; Proll, MA | 1 |
| Cervetto, L; McNaughton, PA | 1 |
| Matsuda, T; Mori, M; Tsushima, H | 1 |
| Angeli, A; Cavallo, R; Gatti, G; Marinone, C; Sartori, ML | 1 |
| Gemba, M; Mikuriya, N; Nakajima, M; Nakanishi, J | 1 |
| Ibay, AC; Martinson, EA; Schneller, SW; Wells, JN | 1 |
| Brandwein, SR | 1 |
| Bittles, AH; Tehrani, MH; Thomas, PJ | 1 |
| Gilboe, DP | 1 |
| Birch, RE; Polmar, SH | 1 |
| Morton, DB; Truman, JW | 1 |
| Taira, N; Takahashi, K; Wada, Y | 1 |
| Espinoza, B; Wharton, W | 1 |
| Dolphin, AC; Forda, SR; Scott, RH | 1 |
| Haugen, SE; Kleveland, PM; Waldum, HL | 1 |
| Gardner, JD; Jensen, RT; Jones, SW; Noguchi, M; Villanueva, ML; Zhou, ZC | 1 |
| DeLander, GE; Hopkins, CJ | 1 |
| Fox, IH; John, D | 1 |
| Adachi, S; Nagahama, Y; Tan, JD | 1 |
| Chabot, MC; Chepenik, KP | 1 |
| Crowley, JJ; Cusack, BJ; Nielson, CP; Vestal, RE | 1 |
| Dar, MS; Wooles, WR | 1 |
| Orekhov, AN; Smirnov, VN; Tertov, VV | 2 |
| Brown, L; Erdmann, E; Lorenz, B | 1 |
| Hattori, Y; Hayashi, Y; Hori, Y; Moriwaki, A | 1 |
| Fredholm, BB; Lerner, U; Ransjö, M | 1 |
| Brown, SJ; Richardson, PJ | 1 |
| Holtzman, SG | 2 |
| Chayoth, R | 1 |
| Cassity, N; Martinez, JR | 1 |
| Dodd, PR; Johnston, GA; Watson, WE | 1 |
| Kishi, Y; Numano, F | 1 |
| Ahrén, B; Lundquist, I; Skoglund, G | 1 |
| Schmeichel, CJ; Thomas, LL | 1 |
| Finger, W; Martin, C | 1 |
| Close, G; Dar, MS; Jones, M; Mustafa, SJ; Wooles, WR | 1 |
| Leung, E; Woodcock, EA | 1 |
| Cooper, CW; Kenny, AD; Pang, PK; Tenner, TE; Yang, MC | 1 |
| Manganiello, VC; Osborne, JC; Wada, H | 1 |
| Dage, RC; Hsieh, CP; Kariya, T; Ruberg, SJ | 1 |
| Segal, J | 1 |
| Ehrenspeck, G; Voner, C | 1 |
| Costello, A; Handwerger, S; Harman, I; Sane, A | 1 |
| Aratani, Y; Kitagawa, Y; Sugimoto, E | 1 |
| Cosowsky, L; Raufman, JP | 2 |
| Maller, JL; Sadler, SE | 2 |
| Cohen, S; Dascal, N | 1 |
| Belloni, FL; Gerritsen, ME; Liang, BC | 1 |
| Greeff, K; Schmitt, M | 1 |
| Bednar, MS; Broner, FA; Hubbard, JR; Sledge, CB; Steinberg, JJ | 1 |
| Cary, DA; Mendelsohn, FA | 1 |
| Bass, SN; Fain, M; Spagnuolo, PJ | 1 |
| Beek, D; Kenakin, TP | 1 |
| Dorsett, JA; Yau, WM; Youther, ML | 1 |
| Hashimoto, H; Ishii, K; Satoh, K; Taira, N | 1 |
| Kleven, MS; Sparber, SB | 2 |
| Aoyama, T; Kimura, H; Otsu, Y | 1 |
| Olashaw, NE; Pledger, WJ | 1 |
| Miledi, R; Woodward, RM | 2 |
| Arapinis, C; Aron, Y; Krishnamoorthy, R; Pello, JY; Swierczewski, E | 1 |
| Houslay, MD; Murphy, GJ | 1 |
| Warbanow, W; Will-Shahab, L | 2 |
| Fickbohm, D; Flamm, RE; Harris-Warrick, RM | 1 |
| Halaban, R; Haq, AK; Kim, GS; Kwon, BS; Pomerantz, S; Usack, L | 1 |
| Chang, G; Dillehay, LE; Williams, JR | 1 |
| Berson, EL; Crane, WG; Pawlyk, BS; Sandberg, MA; Schmidt, SY | 1 |
| Berkowitz, AS; Preslock, JP; Wun, WS | 1 |
| Eckstein, H | 1 |
| Brown, DL; Harris, DM | 1 |
| Brodsky, WA; Durham, JH; Matons, C; Schneider, ES | 1 |
| Aldrich, RW; Garber, SS; Hoshi, T | 1 |
| Dryden, WF; Gordon, T; Lazarenko, G; Singh, YN | 1 |
| Simpson, LL | 1 |
| Böhm, M; Brückner, R; Neumann, J; Nose, M; Schmitz, W; Scholz, H | 1 |
| Bancu, AC; Farrar, W; Gherman, M; Goto, T; Herberman, RB; Sulica, A | 1 |
| Barber, B; Fluck, R; Sguigna, C | 1 |
| Hegde, SS; Lokhandwala, MF | 1 |
| Ogawa, N; Ono, H | 1 |
| Parsons, WJ; Ramkumar, V; Stiles, GL | 1 |
| Gillespie, E | 1 |
| Choi, OH; Daly, JW; Padgett, WL; Shamim, MT | 1 |
| Ribeiro, JA; Sebastião, AM | 1 |
| de Jong, PT; van Haeringen, NJ; Verbey, NL | 1 |
| Miller, JR; Wells, JN | 1 |
| Dasarathy, Y; Fanburg, BL | 1 |
| Kunkel, SL; Larrick, J; Lynch, JP; Remick, DG; Spengler, RN; Strieter, RM; Ward, PA | 1 |
| Daugirdas, JT; Fiscus, RR; Islam, S; Kim, DD; Nutting, C; Swanson, V; Wang, XA | 1 |
| Fredholm, BB; Lerner, UH; Ransjö, M | 1 |
| Aghajanian, GK; Wang, YY | 1 |
| Charette, L; Denis, D; Jones, TR | 1 |
| Berry, L; Brigham, KL; Graber, S; Hussein, A; Meyrick, B | 1 |
| Dacke, CG; Shaw, AJ | 1 |
| Agostini, O; Fedi, M; Manzini, S | 1 |
| Farbman, AI; Gonzales, F; Johnson, RR | 1 |
| Kondo, M; Takizawa, T; Tamaoki, J | 1 |
| Buchou, T; Charollais, RH; Fagot, D; Mester, J | 1 |
| Chiba, S; Haruta, K; Homma, N; Horiuchi, A; Iwatsuki, K; Yonekura, H | 1 |
| Bolanowski, MA; Bouvier, M; Caron, MG; Collins, S; Lefkowitz, RJ | 1 |
| Cervetto, L; Menini, A; Rispoli, G; Torre, V | 1 |
| Copp, RP; Samuels, HH | 1 |
| De Mello, WC | 1 |
| Jackman, SA; Nicholson, CD; Wilke, R | 1 |
| Chua, BH; Haneda, T; Morgan, HE; Watson, PA; Xenophontos, XP | 1 |
| Arch, JR; Nicholson, CD; Wilke, R | 1 |
| Bouvier, M; Campbell, PT; Caron, MG; Collins, S; de Blasi, A; Irons, GP; Kobilka, BK; Lefkowitz, RJ; MacGregor, C; O'Dowd, BF | 1 |
| Stieve, H | 1 |
| Abou-Samra, AB; Jueppner, H; Potts, JT; Segre, GV | 1 |
| Akil, M; Fisher, SK | 1 |
| Kotecha, N; Neild, TO | 1 |
| Rodger, IW; Shahid, M | 1 |
| Coker, SJ; Holbrook, M | 1 |
| Avruch, J; Deutsch, PJ; Grove, JR; Habener, JF; Price, DJ | 1 |
| Brown, BL; Dobson, PR; Evans, DB; Russell, RG | 1 |
| Endou, H; Miyanoshita, A; Takahashi, T | 1 |
| Brazdil, R; Diocee, BK; Jordan, R; Souness, JE | 1 |
| Houslay, MD; Lakey, T; Lavan, BE | 1 |
| Alberts, P | 1 |
| Parthasarathy, R; Srikrishnan, T | 1 |
| Hall, IP; Hill, SJ | 1 |
| Cottney, J; Marsden, G; Nicholson, CD; Shahid, M | 1 |
| Clark, KL; Drew, GM; Hilditch, A | 1 |
| Christensen, O; Randlev, T; Simon, M | 1 |
| Firsov, DL; Kaminskiĭ, IuL; Natochin, IuV; Parnova, RG; Shakhmatova, EI | 1 |
| Mersmann, HJ | 1 |
| Jarkman, S | 1 |
| Perez-Polo, JR; Shen, RS; Zhang, YX | 1 |
| Collawn, JB; Kent, RS; Montgomery, ME; Whorton, AR; Young, SL | 1 |
| Boyd, AE; Hill, RS | 1 |
| Ishibashi, M; Yamaji, T | 1 |
| Draznin, B; Goodman, M; Leitner, JW; Steinberg, JP; Sussman, KE | 1 |
| Brunelle, G; Coquil, JF; Guédon, J | 1 |
| Diaz, C; Gill, JM; Schiffman, SS | 1 |
| Burnside, B; Dearry, A | 1 |
| Furuki, Y; Hatada, Y; Maeyama, M; Miyamoto, E; Munemura, M; Sakoda, Y | 1 |
| Hertting, G; Jackisch, R; Kasakov, L; Strittmatter, H | 1 |
| Fuller, CM; Gallacher, DV | 1 |
| Fredholm, BB | 1 |
| Fermum, R; Leibelt, M; Möritz, KU; Schäfer, U | 1 |
| Brown, BS; Krzanowski, JJ; Polson, JB; Wiggins, JR | 1 |
| Blanchard, W; Gerich, J; Itoh, M; Mandarino, L; Patton, G | 1 |
| Bunge, RP; Glaser, L; Salzer, JL | 1 |
| Halprin, KM; Levine, V; Taylor, JR | 1 |
| Andersson, RG; Börjesson, S; Nilsson, KB | 1 |
| Assaf, A; Bertram, JS; Janik, P | 1 |
| Beers, WH; Dekel, N | 1 |
| Averesch, H; Schulze, JJ | 1 |
| Epstein, PM; Hersh, EM; Ross, CP; Strada, SJ; Thompson, WJ | 1 |
| Lerner, U | 1 |
| Boutwell, RK; Perchellet, JP | 4 |
| Marks, F | 1 |
| Betteridge, A | 1 |
| Hertelendy, F; Zakar, T | 1 |
| Gagnon, G; Regoli, D; Rioux, F | 1 |
| Endoh, M; Satoh, K; Yamashita, S | 1 |
| Challiss, JR; Holman, GD; Taylor, LP | 1 |
| Drake, PF; Treistman, SN | 2 |
| Oleshansky, MA | 1 |
| Blondel, B; Mintz, DH; Murray, T; Rabinovitch, A | 1 |
| Diamond, EJ; Hollander, VP; Mayer, RM | 1 |
| Bergstrand, H | 1 |
| Biegon, RL; Epstein, PM; Pappano, AJ | 1 |
| Abrahamsson, H; Andersson, T; Berggren, PO; Flatt, P; Gylfe, E; Hahn, HJ; Hellman, B | 1 |
| Täljedahl, IB | 1 |
| Hollins, C; Lloyd, H; Stone, TW | 1 |
| Akasu, T; Karczmar, AG | 1 |
| Hagino, Y; Tachibana, M; Tsuru, H; Uematsu, T | 1 |
| Brückner, R; Erdmann, E; Krawietz, W; Schmitz, W; Scholz, H; Schumacher, A; Werdan, K | 1 |
| Collier, HO; Cuthbert, NJ; Francis, DL | 1 |
| Dunn, AJ; Villiger, JW | 1 |
| Court, JM; Dunlop, M; Larkins, RG | 1 |
| Gerber, PP; Miller, RE; Renold, AE; Trimble, ER; Wollheim, CB | 1 |
| Gustafson, GT; Lerner, U | 1 |
| Jackson, GL; Liu, TC; Wang, PS | 1 |
| Dannies, PS; Tam, SW | 1 |
| Hehmke, B; Kohnert, KD; Schröder, D; Ziegler, B; Zühlke, H | 1 |
| Kramer, GL; Wells, JN | 1 |
| Sharp, GW; Wiedenkeller, DE | 1 |
| Dolphin, AC; Greengard, P | 1 |
| Gruschwitz, P; Nawrath, H; Zong, X | 1 |
| Fredholm, B; Sydbom, A; Uvnäs, B | 1 |
| Ray, KP; Wallis, M | 1 |
| Gewirtz, DA; Goldman, ID; Randolph, JK | 1 |
| Pellmar, TC | 1 |
| Capovilla, M; Cervetto, L; Pasino, E; Torre, V | 1 |
| Liao, HH; Thorner, J | 1 |
| Kuroki, T | 1 |
| Beyer, C; Canchola, E | 1 |
| Herman, G; Mauduit, P; Rossignol, B | 1 |
| Ehrenspeck, G | 1 |
| Cohen, AI | 1 |
| Gylfe, E; Hellman, B | 1 |
| Anuras, S | 1 |
| Beyer, C; Canchola, E; Gomora, P; Sandoval, Y | 1 |
| Chiba, A; Nezu, E; Yoshimura, K | 1 |
| Rillema, JA; Wing, LY | 1 |
| Carlberg, KA; Fregly, MJ; Lockley, OE | 1 |
| Gardner, JD; Korman, LY; Sutliff, VE; Walker, MD | 1 |
| Chiba, S; Iijima, F; Iwatsuki, K | 1 |
| Barouski-Miller, PA; Gelehrter, TD | 1 |
| Azuma, K; Azuma, M | 1 |
| Giguère, V; Labrie, F; Meunier, H; Veilleux, R | 1 |
| Boeynaems, JM; Dumont, JE; Erneux, C; Miot, F | 1 |
| Boadle-Biber, MC | 1 |
| Greene, RM; Lloyd, MR; MacAndrew, VI | 1 |
| Przegaliński, E; Rawłów, A | 1 |
| Bombeck, CT; Holian, O; Nyhus, LM | 1 |
| Foley, JE; Kashiwagi, A | 1 |
| Herlin, T; Kragballe, K | 2 |
| Warbanow, W; Wollenberger, A | 1 |
| Blankenship, LC; Craven, SE | 1 |
| Galloway, MP; Roth, RH | 2 |
| Grant, SJ; Redmond, DE | 2 |
| Carchman, RA; Debski, BF; Ranney, RR | 1 |
| Rubin, CS; Schwartz, DA | 1 |
| Amsler, K; Cook, JS; Shaffer, C | 1 |
| Painter, SD | 1 |
| Kann, ML; Serres, C | 1 |
| Amakawa, T; Hayashi, F; Inoue, H; Takagi, M; Yoshioka, T | 1 |
| Swenne, I | 1 |
| Sass, SP; Sheppard, H; Tsien, WH | 1 |
| Florine, DL; Scott, RE; Yun, K | 1 |
| Brotherton, AF; Hoak, JC; Macfarlane, DE | 1 |
| Grimm-Jorgensen, Y | 1 |
| Acott, TS; Critchlow, L; Hoskins, DD; Vijayaraghavan, S | 1 |
| Hirai, M; Komoriyama, K; Kouyama, H; Shima, S | 1 |
| Chajek-Shaul, T; Friedman, G; Stein, O; Stein, Y | 1 |
| Efendić, S; Grill, V; Nylén, A; Ostenson, CG | 1 |
| Bartfai, T; Lazaridis, G; Tjörnhammar, ML | 1 |
| Gifford, L; Griem, K; Little, JB; Umans, RS; Weichselbaum, RR | 1 |
| Bombeck, CT; Holian, O; Nyhus, LM; Ruiz, C | 1 |
| Kopf, GS; Lewis, CA; Vacquier, VD | 3 |
| Ikeda, S; Nishibori, M; Saeki, K | 1 |
| Andreassi, L; Baiocchi, R; Biagioli, M; Fimiani, M; Sbano, E | 1 |
| Kane, TA; Palmer, WK | 1 |
| Novogrodsky, A; Patya, M; Rubin, AL; Stenzel, KH | 1 |
| Galloway, MP; Reinhard, JF; Roth, RH | 1 |
| Ali, NN; Chambers, TJ | 1 |
| Collins, GG; Motley, SJ | 1 |
| Kaplan, SA; Whitson, RH | 1 |
| Gardner, JD; Jensen, RT; Sutliff, VE; Walker, MD | 1 |
| Dollery, CT; Ennis, M; Robinson, C | 1 |
| Foley, JE; Huecksteadt, TP; Kashiwagi, A | 1 |
| Hidaka, H; Manganiello, VC; Osborne, JC; Vaughan, M; Yamamoto, S; Yamamoto, T | 1 |
| Adachi, K; Comerford, M; Halprin, KM; Levine, V; Taylor, JR; Woodyard, C | 1 |
| Capovilla, M; Cervetto, L; Torre, V | 1 |
| Bolkenius, F; Claverie, N; Danzin, C; Grove, J; Wagner, J | 1 |
| Hong, SL | 1 |
| Downs, SM; Eppig, JJ | 1 |
| Cvet, D; Logothetopoulos, J; Valiquette, N | 1 |
| Ishikawa, Y; Takahashi, T; Yamamura, T | 1 |
| Daniel, JW; Oleinick, NL | 1 |
| Kagan, VE; Polianskiĭ, NB; Shvedova, AA; Smirnov, LD | 1 |
| Budohoski, L; Challiss, RA; McManus, B; Newsholme, EA | 1 |
| Bos, MP; Krans, HM; van Dam, K; van Putten, JP; Weringa, T | 1 |
| Hahn, HJ; Kohnert, KD; Noack, S; Ziegler, B | 1 |
| Budzik, GP; Donahoe, PK; Hutson, JM; Ikawa, H | 1 |
| Kumegawa, M; Sakagishi, Y; Tashima, Y; Yora, T | 1 |
| Epstein, PM; Hachisu, R | 1 |
| Kagan, VE; Muranov, KO; Polianskiĭ, NB; Shvedova, AA; Smirnov, LD | 1 |
| Plagemann, PG; Wohlhueter, RM | 1 |
| Armstrong, DT; Reddoch, RB | 1 |
| Wainwright, LK; Wainwright, SD | 1 |
| Curtis-Prior, PB; Tan, S | 1 |
| Ceriani, T; Moggio, R; Ventura, U | 1 |
| Henquin, JC; Meissner, HP | 1 |
| Altman, HJ; Barraco, RA; Coffin, VL; Phillis, JW; Taylor, JA | 1 |
| Hsueh, AJ; Jia, XC; Welsh, TH | 1 |
| Dobbins, JW; Forrest, JN; Laurenson, JP | 1 |
| Fujioka, H | 1 |
| Nathanson, JA | 1 |
| Stellwagen, RH; Strinden, ST | 1 |
| Jiang, CS; Kilfeather, SA; Pearson, RM; Turner, P | 1 |
| Shechter, Y | 1 |
| Howell, SL; Tyhurst, M | 1 |
| Bittar, EE; Bittar, R; Ueno, K | 1 |
| Goldschmit, D; Mizrachi, L; Orly, J; Weinberger-Ohana, P | 1 |
| Bierman, EL; Hokland, BM; Oram, JF; Slotte, JP | 1 |
| Ballati, L; Evangelista, S; Manzini, S; Meini, S | 1 |
| Wyskovsky, W | 1 |
| Becq, F; Buchwald, M; Chang, XB; Hanrahan, JW; Jensen, TJ; Riordan, JR; Rommens, JM; Savoia, A; Tsui, LC | 1 |
| Bertacca, A; Cini, M; Franceschelli, F; Mazzetti, P; Minks, MA; Simili, M | 1 |
| Rezai, K; Wasserman, WJ | 1 |
| Hatzelmann, A; Schudt, C; Tenor, H | 1 |
| Usachev, Y; Verkhratsky, A | 1 |
| Schudt, C; Sybrecht, GW; Ukena, D | 1 |
| Becq, F; Fanjul, M; Figarella, C; Gola, M; Hollande, E; Merten, M | 1 |
| Kostyuk, PG; Lukyanetz, EA | 1 |
| Fujii, W; Namba, T; Suga, H; Takaki, M | 1 |
| Gabrilovac, J | 1 |
| Palade, P; Zahradník, I | 1 |
| Spessert, R; Vollrath, L | 1 |
| Botana, LM; Estévez, MD; Vieytes, MR | 1 |
| Chen, B; Choi, GH; Gao, S; Nuss, DL | 1 |
| Bredenbröker, D; Fehmann, HC; Schudt, C; Schwarz, F; Von Wichert, P; Wagner, U | 1 |
| Agalakova, NI; Gusev, GP; Lapin, AV | 1 |
| Anderson, N; Peachell, PT; Weston, MC | 1 |
| Capasso, F; Costa, M; Izzo, AA; Mascolo, N | 1 |
| De Sarro, A; De Sarro, G; Grasso, S; Nava, F; Zappala, M | 1 |
| Anderson, PJ; Fujikura, Y; Suzuki, R | 1 |
| Agematsu, K; Hu, B; Komiyama, A; Nakazawa, T; Yasui, K | 1 |
| Bobkiewicz-Kozlowska, T; Forjasz-Grus, R | 1 |
| Apland, JP; Helekar, SA; Lebeda, FJ | 1 |
| Brundege, JM; Diao, L; Dunwiddie, TV; Proctor, WR | 1 |
| Kildalsen, H; Sager, G; Schultz, C; Vaskinn, S | 1 |
| Dormer, RL; Lloyd Mills, C; McPherson, MA; Pereira, MM | 1 |
| Buratti, T; Dunzendorfer, S; Herold, M; Kähler, CM; Reinisch, N; Schratzberger, P; Tilg, H; Wiedermann, CJ | 1 |
| Sawada, M; Suzumura, A; Takayanagi, T; Tamaru, T; Yoshikawa, M | 1 |
| Carraway, RE; Mitra, SP | 1 |
| Brock, JA; Hardy, TA | 1 |
| Goto, T; Hida, A; Hosaka, Y; Kasuya, Y; Kawabe, K; Kitamura, T; Matsushima, H; Ohta, Y; Simizu, T; Takeda, K | 1 |
| Daly, JW; Shi, D | 1 |
| Duval, C; Galey, JB; Lagrange, A; Philippe, M; Régnier, M; Schmidt, R; Tuloup, R | 1 |
| Starodub, AM; Wood, JD | 1 |
| Christophersen, P; Jensen, BS; Olesen, SP; Schrøder, RL; Strøbaek, D | 1 |
| Becq, F; Bulteau, L; Dérand, R; Dormer, RL; Folli, C; Galietta, LJ; Joffre, M; Jougla, C; McNeilly, CM; Métayé, T; Mettey, Y; Morris, MR; Pereira, MM; Vierfond, JM; Zegarra-Moran, O | 1 |
| Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N | 1 |
| Seidler, FJ; Slotkin, TA | 1 |
| Crumpton, TL; Seidler, FJ; Slotkin, TA | 1 |
| Esselstyn, J; Hertel, C; Lee, R; Lerner, A; Moon, E; Wolda, S | 1 |
| Iarots'kyĭ, VV; Marchenko, SM; Sahach, VF | 1 |
| Harayama, H; Kato, S | 1 |
| Anderson, KE; Daniele, N; Foukas, LC; Jensen, J; Ktori, C; Shepherd, PR | 1 |
| Baskakov, MB; D'yakova, EY; Kapilevich, LV; Kovalev, IV; Nosarev, AV | 1 |
| Darlath, W; Gillissen, A; Juergens, UR; Libertus, H; Stöber, M; Vetter, H | 1 |
| Chaube, R; Joy, KP | 2 |
| Alonso, GD; Flawiá, MM; Schoijet, AC; Torres, HN | 1 |
| Anderson, CM; Thwaites, DT | 1 |
| Martini, CN; Plaza, MV; Vila, Mdel C | 1 |
| Kim, HM; Lee, GH; Lee, JW; Lee, MS; Moon, EY | 1 |
| Crisp, KM; Gallagher, BR; Mesce, KA | 1 |
| Bruserud, O; Døskeland, SO; Gausdal, G; Gjertsen, BT; Havemann, U; Herfindal, L; Kleppe, R; Lanotte, M; McCormack, E; Nguyen, E; Pendino, F; Rouhee, N; Schwede, F; Ségal-Bendirdjian, E; Skavland, J; Wergeland, A | 1 |
7 review(s) available for theophylline and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Platelets; Calmodulin; Cardiotonic Agents; Guinea Pigs; Humans; Hypersensitivity; In Vitro Techniques; Lung Diseases; Myocardium; Platelet Aggregation; Substrate Specificity | 1985 |
Adenosine receptors: targets for future drugs.
Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1982 |
Gastrointestinal and metabolic effects of methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Caffeine; Calcium; Carbohydrate Metabolism; Digestive System; Energy Metabolism; Esophagus; Gastric Acid; Humans; Lipid Metabolism; Lipolysis; Liver; Pancreas; Saliva; Theophylline; Thyroid Gland; Xanthines | 1984 |
Phosphodiesterase inhibition and theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Cromolyn Sodium; Histamine Release; Humans; Kinetics; Lung; Muscle Relaxation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Theophylline | 1980 |
Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Isoenzymes; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 1981 |
Cyclic nucleotide phosphodiesterase in normal and leukemic human lymphocytes and lymphoblasts.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Caffeine; Cells, Cultured; Humans; Kinetics; Leukemia; Lymphocyte Activation; Lymphocytes; Reference Values; Theophylline | 1984 |
Insulin secretion: the effector system.
Topics: 1-Methyl-3-isobutylxanthine; Actomyosin; Animals; C-Peptide; Calcium; Cell Membrane; Colchicine; Cyclic AMP; Cytoplasmic Granules; Cytoskeleton; Exocytosis; Insulin; Insulin Secretion; Islets of Langerhans; Microtubule-Associated Proteins; Microtubules; Models, Biological; Myosins; Theophylline; Vimentin; Vinblastine | 1984 |
459 other study(ies) available for theophylline and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Imidazodiazepinediones: a new class of adenosine receptor antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Azepines; Binding, Competitive; Cell Membrane; Cerebral Cortex; Diazepam; Imidazoles; In Vitro Techniques; Molecular Conformation; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Structure-Activity Relationship | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.
Topics: Animals; Brain; Cell Membrane; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Rats; Receptors, Purinergic; Structure-Activity Relationship; Xanthines | 1989 |
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.
Topics: Animals; Caffeine; Cell Membrane; Cerebral Cortex; Indicators and Reagents; Mass Spectrometry; Rats; Receptors, Purinergic; Structure-Activity Relationship; Theophylline; Xanthines | 1986 |
Mesoionic xanthine analogues: phosphodiesterase inhibitory and hypotensive activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antihypertensive Agents; Blood Pressure; Cattle; In Vitro Techniques; Male; Pyrimidinones; Rats; Structure-Activity Relationship; Thiadiazines; Thiazines | 1981 |
Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor.
Topics: Animals; Base Sequence; Brain; Cattle; DNA Primers; Escherichia coli; GTP-Binding Proteins; Humans; Molecular Sequence Data; Protein Binding; Receptors, Purinergic P1; Recombinant Proteins; Species Specificity | 1994 |
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
Topics: Animals; Brain; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline; Xanthines | 1993 |
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.
Topics: Acylation; Alkylation; Animals; Brain; Caffeine; Cell Membrane; Cyclization; Molecular Structure; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Trifluoroacetic Acid; Xanthines | 1993 |
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.
Topics: Estradiol; Female; Humans; In Vitro Techniques; Male; Metribolone; Pregnenediones; Prostate; Receptors, Androgen; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Receptors, Steroid; Thermodynamics; Uterus | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 7; Dose-Response Relationship, Drug; Drug Design; Endotoxemia; Humans; Hydrazines; Lipopolysaccharides; Male; Molecular Structure; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Structure-Activity Relationship | 2018 |
Cholinergic stimulation of skeletal muscle alanine and glutamine formation and release. Evidence for mediation by a nicotinic cholinergic receptor and guanosine 3':5'-monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Alanine; Animals; Atropine; Carbachol; Cyclic AMP; Cyclic GMP; Glutamine; Hexamethonium Compounds; Muscles; Phosphorylases; Pilocarpine; Quaternary Ammonium Compounds; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Theophylline | 1978 |
Cylic AMP inhibition of mammary gland lactose synthesis: specificity and potentiation by 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Lactose; Mammary Glands, Animal; Structure-Activity Relationship; Theophylline | 1978 |
Effect of a phosphodiesterase inhibitor, 3-isobutyl 1-methylxanthine, upon the stimulatory effect of human follicle-stimulating hormone and human luteinizing hormone upon cyclic adenosine 3':5'-monophosphate accumulation by porcine granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Drug Synergism; Female; Follicle Stimulating Hormone; Granulosa Cells; In Vitro Techniques; Luteinizing Hormone; Phosphoric Diester Hydrolases; Swine; Theophylline | 1978 |
Prostaglandin inhibition of testosterone production induced by luteinizing hormone, dibutyryl cyclic AMP or 3-isobutyl-1-methyl xanthine in dispersed rat testicular interstitial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; In Vitro Techniques; Indomethacin; Luteinizing Hormone; Male; Prostaglandins; Radioimmunoassay; Rats; Testis; Testosterone; Theophylline | 1978 |
Uptake and metabolism of histamine in guinea pig ileal longitudinal muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amines; Animals; Guanidines; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Muscle, Smooth; Theophylline | 1978 |
Effect of a phosphodiesterase inhibitor on cyclic GMP changes induced by muscarinic agonists in mouse neuroblastoma cells [proceedings].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Mice; Neuroblastoma; Parasympathomimetics; Theophylline | 1978 |
Temperature sensitivity of cyclic AMP production and catecholamine-induced refractoriness in a rat astrocytoma cell line.
Topics: 1-Methyl-3-isobutylxanthine; Astrocytoma; Cell Line; Cyclic AMP; Isoproterenol; Kinetics; Temperature; Theophylline | 1978 |
Development of lipoprotein lipase activity and accumulation of triacylglycerol in differentiating 3T3-L1 adipocytes. Effects of prostaglandin F2alpha, 1-methyl-3-isobutylxanthine, prolactin, and insulin.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Cell Differentiation; Cell Line; Enzyme Induction; Insulin; Kinetics; Lipoprotein Lipase; Prolactin; Prostaglandins F; Theophylline; Triglycerides | 1979 |
Differential sensitivities of normal human and chronic lymphocytic leukemia lymphocytes to 1-methyl,3-isobutylxanthine and N6-2'-o-dibutyryl adenosine-3',5'-cyclic monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenosine Monophosphate; Adult; Bucladesine; Cell Survival; Female; Humans; Leukemia, Lymphoid; Lymphocytes; Male; Middle Aged; Theophylline; Time Factors | 1978 |
Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic AMP; Cyclic GMP; Imidazoles; Liver; Male; Myocardium; Organ Specificity; Papaverine; Phosphates; Phosphodiesterase Inhibitors; Rats; Theophylline | 1978 |
A possible role for cyclic GMP in mediating the effect of luteinizing hormone releasing hormone on gonadotropin release in dispersed pituitary cells of the female rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Theophylline | 1978 |
Prolactin-suppressive effects of two aminotetralin analogs of dopamine: their use in the characterization of the pituitary dopamine receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Haloperidol; Male; Naphthols; Phentolamine; Pituitary Gland, Anterior; Prolactin; Propranolol; Rats; Receptors, Dopamine; Structure-Activity Relationship; Tetrahydronaphthalenes; Theophylline | 1979 |
Effects of L-isopropylnorepinephrine, 3-isobutyl-1-methyl xanthine and dibutyryl cyclic AMP on hexose uptake and metabolism by rat striatal slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bucladesine; Corpus Striatum; Glucose; Hexoses; Lactates; Norepinephrine; Oxygen Consumption; Rats; Theophylline | 1979 |
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Animals; Caffeine; Dogs; Etazolate; Female; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Pyrazines; Theophylline; Trachea; Triazoles | 1979 |
Changes in morphology and cell cycle traverse induced in CHO cells by methyl isobutyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Cycle; Cell Line; Cricetinae; Cyclic AMP; DNA; Epithelial Cells; Fibroblasts; Microtubules; Mitosis; Theophylline; Thymidine | 1979 |
Induction of alkaline phosphatase activity in HeLa cells. Inhibition by xanthine derivatives and thermostability studies.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Enzyme Induction; HeLa Cells; Hot Temperature; Humans; Protein Denaturation; Theophylline; Time Factors; Xanthines | 1979 |
Methacholine-induced attenuation of methylisobutylxanthine- and isoproterenol-elevated cyclic AMP levels in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Electric Stimulation; Female; In Vitro Techniques; Isoproterenol; Methacholine Compounds; Myocardium; Rats; Theophylline | 1979 |
The inhibitory effect of xanthine derivatives on alkaline phosphatase in the rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Aminophylline; Animals; Caffeine; Cerebral Cortex; Female; Histocytochemistry; Male; Rats; Synaptosomes; Theophylline; Xanthines | 1979 |
Molecular control of rabbit follicular testosterone production: role of cyclic AMP and cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Female; Ovary; Protein Biosynthesis; Puromycin; Rabbits; RNA; Testosterone; Theophylline | 1979 |
Glucose-dependent effect of methylaxanthines on the 45Ca distribution in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Glucose; Islets of Langerhans; Mice; Subcellular Fractions; Theophylline | 1979 |
Modulation of cellular interactions between C3H/10T1/2 cells and their transformed counterparts by phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Communication; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Contact Inhibition; Cyclic AMP; Embryo, Mammalian; Fibroblasts; In Vitro Techniques; Methylcholanthrene; Mice; Phosphodiesterase Inhibitors; Theophylline | 1979 |
Inhibition of lipolysis in hamster epididymal adipocytes by selective alpha-adrenergic agents. Evidence for cyclic AMP-dependent and independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cholera Toxin; Cricetinae; Cyclic AMP; In Vitro Techniques; Isoproterenol; Lipid Mobilization; Male; Mesocricetus; Methoxamine; Phenylephrine; Theophylline | 1979 |
Effect of cAMP on acrosome reaction and fertilization.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Bucladesine; Caffeine; Cricetinae; Cyclic AMP; Female; Fertilization; Guinea Pigs; Imidazoles; Male; Ovum; Phosphodiesterase Inhibitors; Sperm Motility; Spermatozoa; Theophylline | 1979 |
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: relationship of enzyme activity to cyclic AMP concentrations.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Induction; HeLa Cells; Humans; Hydrocortisone; Idoxuridine; Theophylline; Xanthines | 1979 |
Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Bucladesine; Disease Models, Animal; Inflammation; Mopidamol; Phosphodiesterase Inhibitors; Prostaglandins E; Rats; Theophylline | 1979 |
Histamine and cyclic AMP in isolated canine parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Bucladesine; Carbachol; Cyclic AMP; Dogs; Gastric Mucosa; Gastrins; Histamine; Oxygen Consumption; Theophylline | 1979 |
Methyl xanthines, adenosine 3',5'-cyclic monophosphate and the spinal transmission of nociceptive information.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cats; Cyclic AMP; Injections, Intravenous; Pain; Spinal Cord; Substantia Gelatinosa; Synaptic Transmission; Theophylline; Time Factors; Xanthines | 1979 |
Two effects of phosphodiesterase inhibitors on Limulus ventral photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Horseshoe Crabs; Membrane Potentials; Papaverine; Photic Stimulation; Photoreceptor Cells; Theophylline | 1979 |
Effects of calcium-blocking agents and phosphodiesterase inhibitors on voltage-dependent conductances in Limulus photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Gallopamil; Horseshoe Crabs; Membrane Potentials; Papaverine; Photic Stimulation; Photoreceptor Cells; Potassium; Synaptic Transmission; Theophylline | 1979 |
Radioprotection of mouse intestine by inhibitors of cyclic AMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Cell Survival; Jejunum; Male; Mice; Radiation-Protective Agents; Reserpine; Theophylline | 1979 |
PGI2 enhanced cAMP content in bovine coronary arteries in the presence of isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; Dipyridamole; Epoprostenol; In Vitro Techniques; Indomethacin; Prostaglandins; Stimulation, Chemical; Theophylline; Time Factors | 1979 |
Differentiation of 3T3-L2 fibroblasts into adipose cells in bromodeoxyuridine-suppressed cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; DNA; Fibroblasts; Mice; Theophylline | 1979 |
Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Brain; Caffeine; Cerebral Cortex; Male; Neural Inhibition; Neurons; Rats; Synapses; Synaptic Transmission; Theophylline | 1979 |
1-Isoamyl-3-isobutylxanthine: a remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Cyclic AMP; Drug Synergism; Guinea Pigs; Histamine; In Vitro Techniques; Male; Norepinephrine; Phosphodiesterase Inhibitors; Theophylline; Xanthines | 1979 |
Augmentation of the in vitro humoral immune response by pharmacologic agents. I: An explanation for the differential enhancement of humoral immunity via agents that elevate cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antibody Formation; B-Lymphocytes; Bucladesine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Female; Isoproterenol; Mice; Spleen; T-Lymphocytes; Theophylline; Time Factors | 1979 |
Evidence for involvement of A1 adenosine receptors in neurotensin-induced hypothermia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Hypothermia; Male; Neurotensin; Purinergic Antagonists; Rats; Theobromine; Theophylline | 1992 |
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Caffeine; Electroencephalography; Male; Parasympatholytics; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Theophylline; Xanthines | 1992 |
Cyclic nucleotide phosphodiesterases from frog atrial fibers: isolation and drug sensitivities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Chloride; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Cytosol; Dipyridamole; Heart Atria; Heart Ventricles; Kinetics; Myocardium; Papaverine; Purinones; Pyrrolidinones; Rana esculenta; Rana ridibunda; Rolipram; Substrate Specificity; Theophylline | 1992 |
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.
Topics: 1-Methyl-3-isobutylxanthine; Aprotinin; Blotting, Northern; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replication; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Leupeptins; Male; Pentoxifylline; Phenylmethylsulfonyl Fluoride; Prostatic Neoplasms; RNA, Neoplasm; Theophylline; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Azelastine potentiates the prostaglandin-induced increase of cyclic AMP content in human platelets and in guinea-pig alveolar macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Blood Platelets; Cell Survival; Cyclic AMP; Dinoprostone; Drug Synergism; Epoprostenol; Guinea Pigs; Humans; In Vitro Techniques; Macrophages, Alveolar; Phthalazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Theophylline | 1992 |
Effect of phosphodiesterase inhibitors on bovine ciliary muscle and outflow facility.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Animals; Aqueous Humor; Caffeine; Cattle; Ciliary Body; Muscle Contraction; Perfusion; Phosphodiesterase Inhibitors; Theophylline | 1992 |
Effect of cAMP elevating compounds on inhibition of gap junctional communication and induction of morphological transformation in Syrian hamster embryo cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Cholera Toxin; Colforsin; Cricetinae; Cyclic AMP; Embryo, Mammalian; Intercellular Junctions; Mesocricetus; Tetradecanoylphorbol Acetate; Theophylline | 1992 |
Effects of cAMP and IBMX on the chick retinal pigment epithelium. Membrane potentials and light-evoked responses.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Chickens; Choroid; Cyclic AMP; Electroretinography; Membrane Potentials; Perfusion; Photic Stimulation; Pigment Epithelium of Eye; Potassium; Retina; Theophylline | 1990 |
Inhibition of the signaling pathways for macrophage proliferation by cyclic AMP. Lack of effect on early responses to colony stimulating factor-1.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Northern; Carrier Proteins; Cell Division; Cells, Cultured; Cholera Toxin; Colony-Stimulating Factors; Cyclic AMP; Dinoprostone; DNA Replication; Female; Gene Expression; Hematopoietic Stem Cells; Kinetics; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred CBA; Oncogenes; Protein Biosynthesis; Signal Transduction; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Theophylline | 1990 |
Mechanism for the emetic side effect of xanthine bronchodilators.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Ferrets; Male; Nausea; Phosphodiesterase Inhibitors; Theophylline; Vomiting; Xanthines | 1990 |
Differential effects of Ro 20-1724 and isobutylmethylxanthine on the basal force of contraction and beta-adrenoceptor-mediated response in the rat ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Imidazoles; In Vitro Techniques; Isoenzymes; Isoproterenol; Male; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Theophylline | 1990 |
Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Cerebral Cortex; Colforsin; Cyclic AMP; Male; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Modulation of gamma-aminobutyric acid release in cerebral cortex by fluoride, phorbol ester, and phosphodiesterase inhibitors: differential sensitivity of acetylcholine release to fluoride and K+ channel blockers.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Phorbol Esters; Phosphodiesterase Inhibitors; Potassium; Potassium Channels; Rats; Sodium Fluoride; Tacrine; Theophylline | 1990 |
Subtype-specific cyclic AMP-dependent histone H1 phosphorylation at the differentiation of mouse neuroblastoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Caffeine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Histones; Mice; Neuroblastoma; Peptide Mapping; Phosphates; Phosphopeptides; Phosphorylation; Theophylline; Tumor Cells, Cultured; Tyrosine | 1990 |
Modulation of carbachol-induced inositol phosphate formation in bovine tracheal smooth muscle by cyclic AMP phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Animals; Calcium; Carbachol; Cattle; Colforsin; Cyclic AMP; Drug Interactions; In Vitro Techniques; Inositol Phosphates; Male; Membrane Lipids; Muscle, Smooth; Phospholipids; Purinones; Pyrrolidinones; Rolipram; Theophylline; Trachea | 1990 |
Distinct effects of calcium- and cyclic AMP-enhancing factors on cytoskeletal synthesis and assembly in mouse osteoblastic cells.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Alkaline Phosphatase; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytoskeletal Proteins; DNA Replication; Kinetics; Mice; Osteoblasts; Parathyroid Hormone; Theophylline; Tubulin; Vimentin | 1990 |
Inhibition by adenosine 3':5'-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Cell Line; Colforsin; Cyclic AMP; Eicosanoids; Kinetics; Leukotrienes; Mast Cells; Mice; Platelet Activating Factor; Prostaglandin D2; Theophylline | 1990 |
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Animals; Bone and Bones; Bone Resorption; Calcium; Cyclic AMP; Dideoxyadenosine; DNA Replication; In Vitro Techniques; Indomethacin; Isomerism; Kinetics; Mice; Parathyroid Hormone; Phenylalanine; Protein Biosynthesis; Theophylline | 1990 |
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine | 1990 |
Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Acyltransferases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Coenzyme A Ligases; Fatty Acids; Humans; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Theophylline | 1990 |
Intracellular coupling of prostaglandin inhibition of acid secretion in isolated rabbit gastric parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Aminopyrine; Animals; Anti-Ulcer Agents; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Gastric Acid; Histamine Antagonists; Inositol Phosphates; Misoprostol; Parietal Cells, Gastric; Rabbits; Theophylline | 1990 |
Propranolol inhibits cyclic AMP accumulation and amylase secretion in parotid acinar cells stimulated by isobutylmethylxanthine and forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Alprenolol; Amylases; Animals; Atenolol; Butoxamine; Colforsin; Cyclic AMP; Male; Membrane Proteins; Parotid Gland; Poly(ADP-ribose) Polymerases; Propranolol; Rats; Rats, Inbred Strains; Saponins; Theophylline | 1990 |
Interleukin 1 interacts synergistically with forskolin and isobutylmethylxanthine in stimulating bone resorption in organ culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Colforsin; Drug Synergism; Interleukin-1; Organ Culture Techniques; Osteoblasts; Osteoclasts; Rats; Theophylline | 1990 |
Metabolic control of the K+ channel of human red cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Calcium; Cyclic AMP; Erythrocyte Membrane; Guanosine Triphosphate; Humans; Kinetics; Magnesium; Potassium; Potassium Channels; Protein Kinases; Spectrophotometry, Atomic; Theophylline | 1990 |
The role of adenosine in the hyperaemic response of the hepatic artery to portal vein occlusion (the 'buffer response').
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Dogs; Dose-Response Relationship, Drug; Female; Hepatic Artery; Hyperemia; In Vitro Techniques; Male; Portal Vein; Theophylline | 1990 |
Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Fetus; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Isoproterenol; Kinetics; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Rats; Rats, Inbred Strains; Somatomedins; Teriparatide; Theophylline; Transcription, Genetic | 1990 |
Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Corticosterone; Culture Media; Cyclic AMP; DNA Replication; Epidermal Growth Factor; Insulin-Like Growth Factor I; Kinetics; Mice; Somatomedins; Theophylline | 1990 |
17 beta-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Colforsin; Cyclic AMP; Cyclic GMP; Drug Implants; Electric Conductivity; Estradiol; Female; Guinea Pigs; Hypothalamus; Imidazoles; Membrane Potentials; Neurons; Ovariectomy; Potassium; Theophylline | 1990 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; B-Lymphocytes; Blotting, Northern; Caffeine; Cell Line; Cyclic AMP; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Kinetics; Mice; Plasmids; Recombination, Genetic; RNA, Messenger; T-Lymphocytes; Theophylline; Transfection | 1990 |
Regulation of pancreastatin release from a human pancreatic carcinoid cell line in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carcinoid Tumor; Cell Line; Chromatography, Gel; Chromogranin A; Chromogranins; Humans; Ionomycin; Kinetics; Monensin; Pancreatic Hormones; Pancreatic Neoplasms; Phorbol Esters; Radioimmunoassay; Second Messenger Systems; Theophylline | 1991 |
cAMP analogs and selective inhibitors used to study low Km Mucor rouxii cAMP phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Centrifugation, Density Gradient; Cyclic AMP; Cyclic GMP; Dipyridamole; Hydrolysis; Mucor; Nicotinic Acids; Papaverine; Pyridazines; Theophylline | 1990 |
Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.
Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Adrenergic beta-Agonists; Animals; Bronchodilator Agents; Carbachol; Guinea Pigs; In Vitro Techniques; Isoproterenol; Leukotriene E4; Lung; Male; Muscle Contraction; Muscle Relaxation; Receptors, Immunologic; Receptors, Leukotriene; SRS-A; Tetrazoles; Theophylline; Trachea | 1990 |
Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Albuterol; Bucladesine; Cell Degranulation; Cholera Toxin; Cyclic AMP; Dinoprostone; Eosinophils; Humans; Immunoglobulin G; In Vitro Techniques; Isoproterenol; Signal Transduction; Theophylline | 1991 |
Free calcium transients and oscillations in nerve cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; Fura-2; Guanylyl Imidodiphosphate; Helix, Snails; Membrane Potentials; Microelectrodes; Neurons; Theophylline; Thymol; Xanthines | 1991 |
Adenosine deaminase increases release of excitatory amino acids through a mechanism independent of adenosine depletion.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adenosine-5'-(N-ethylcarboxamide); Amino Acids; Animals; Aspartic Acid; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Female; Hydrolysis; Phosphatidylinositols; Rats; Rats, Inbred Strains; Theophylline | 1991 |
[The effect of intracellular calcium on an increase in the cAMP-mediated calcium current].
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Animals; Calcium; Calcium Channels; Creatinine; Cyclic AMP; Drug Combinations; Drug Interactions; Egtazic Acid; Helix, Snails; In Vitro Techniques; Membrane Potentials; Neurons; Serotonin; Theophylline; Trifluoperazine | 1991 |
Effects of the triazolopyrimidine trapidil on force of contraction, beating frequency and phosphodiesterase I--IV activity in guinea-pig hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromatography, DEAE-Cellulose; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoenzymes; Male; Milrinone; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Pyridones; Theophylline; Trapidil | 1991 |
Phosphorylation of nuclear proteins in myelinating oligodendrocytes and its control by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aging; Animals; Brain; Cyclic AMP; Kinetics; Molecular Weight; Myelin Sheath; Nuclear Proteins; Oligodendroglia; Phosphorylation; Protein Kinases; Rats; Rats, Inbred Strains; Theophylline | 1991 |
On the pharmacological phenocopying of memory mutations in Drosophila: alkylxanthines accelerate memory decay.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Association Learning; Cyclic AMP; Drosophila melanogaster; Mental Recall; Mutation; Phenotype; Theophylline | 1991 |
Inhibitors of phosphodiesterase III block stimulation of Xenopus laevis oocyte ribosomal S6 kinase activity by insulin-like growth factor-I.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cricetinae; Female; Insulin-Like Growth Factor I; Meiosis; Oocytes; Oogenesis; Papaverine; Phosphodiesterase Inhibitors; Protein Kinases; Pyridazines; Pyrrolidinones; Ribosomal Protein S6 Kinases; Rolipram; Theophylline; Xenopus laevis | 1991 |
2-Chloro-[3H]-adenosine binding in isolated rat kidney membranes.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Binding, Competitive; In Vitro Techniques; Kidney; Rats; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1985 |
Characteristics of adenosine binding sites in atrial sarcolemmal membranes.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding Sites; Binding, Competitive; Cattle; Endopeptidases; Heart Atria; Myocardium; Sarcolemma; Subcellular Fractions; Theophylline; Time Factors | 1985 |
[Action of cyclic nucleotide phosphodiesterase inhibitors on the acetylcholine potential].
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Bucladesine; Caffeine; Diaphragm; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Membrane Potentials; Mice; Muscles; Theophylline | 1985 |
Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Calcium; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart; Ion Channels; Isoproterenol; Myocardial Contraction; Stimulation, Chemical; Theophylline | 1985 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
Adenosine receptors on canine parietal cells modulate gastric acid secretion to histamine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Dogs; Dose-Response Relationship, Drug; Female; Gastric Acid; Histamine; In Vitro Techniques; Male; Parietal Cells, Gastric; Phenylisopropyladenosine; Prostaglandins; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1985 |
Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Baclofen; Clonidine; Drug Interactions; Male; Neural Pathways; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Reaction Time; Theophylline | 1985 |
Regulation of galactokinase gene expression in Tetrahymena thermophila. I. Intracellular catecholamine control of galactokinase expression.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Caffeine; Catecholamines; Cyclic AMP; Galactokinase; Genes; Glucagon; Glucose; Histamine; Insulin; Kinetics; Tetrahymena; Theophylline | 1985 |
Divergent effects on LH and FSH synthesis and release from intact female rat pituitary glands in vitro by methylxanthines, cyclic AMP derivatives and sodium fluoride.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cyclic AMP; Female; Follicle Stimulating Hormone; In Vitro Techniques; Luteinizing Hormone; Pituitary Gland; Rats; Rats, Inbred Strains; Sodium Fluoride; Theophylline; Xanthines | 1985 |
Cyclic AMP-induced changes in membrane conductance of Necturus gallbladder epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Chlorides; Cyclic AMP; Electric Conductivity; Epithelium; Gallbladder; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials; Models, Biological; Mucous Membrane; Necturus; Theophylline | 1985 |
Indirect effects of adenosine triphosphate on chloride secretion in mammalian colon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Chlorides; Colon; Epithelium; In Vitro Techniques; Indomethacin; Kinetics; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1985 |
The antagonistic effects of 5-hydroxytryptamine and methylxanthine on the gill cilia of Mytilus edulis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bivalvia; Cell Movement; Cilia; Dose-Response Relationship, Drug; Gills; Photometry; Seawater; Serotonin; Theophylline; Time Factors | 1985 |
A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Azo Compounds; Cell Differentiation; Cell Line; Dexamethasone; Glycerolphosphate Dehydrogenase; Insulin; Lipid Metabolism; Mice; Phenylisopropyladenosine; Quinolines; Quinolones; Solubility; Theophylline; Time Factors | 1985 |
Adenosine-sensitive adenylate cyclase in rat anterior pituitary.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Cations, Divalent; Deoxyadenosines; Female; Guanine Nucleotides; In Vitro Techniques; Phenylisopropyladenosine; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Theophylline | 1985 |
Stimulation by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine of rat hepatic polyamine biosynthesis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Female; Liver; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Theophylline | 1985 |
Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Alprenolol; Animals; Bucladesine; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Chick Embryo; Cyclic AMP; Ion Channels; Isoproterenol; Muscles; Nifedipine; Nitrendipine; Receptors, Nicotinic; Reserpine; Theophylline | 1985 |
Forskolin stimulates bovine epididymal sperm motility and cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bicarbonates; Cattle; Cell Membrane; Colforsin; Cyclic AMP; Dibucaine; Epididymis; Kinetics; Male; Manganese; Sodium Fluoride; Sperm Motility; Spermatozoa; Theophylline | 1985 |
Characterization of a calcium-modulated adenylate cyclase from abalone spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcimycin; Calcium; Cations, Divalent; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Male; Mollusca; Spermatozoa; Theophylline | 1985 |
Effectors of rat lung cGMP binding protein-phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Allosteric Regulation; Animals; Binding, Competitive; Cations, Divalent; Hemin; Kinetics; Lung; Nucleotides, Cyclic; Protein Binding; Rats; Theophylline | 1985 |
Effects of cyclic adenosine 3':5'-monophosphate-elevating agents and retinoic acid on differentiation in retinoid-deficient tracheal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Differentiation; Cells, Cultured; Cholera Toxin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Isoproterenol; Keratins; Phosphodiesterase Inhibitors; Retinoids; Theophylline; Trachea; Tretinoin | 1985 |
Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Chlordiazepoxide; Conditioning, Psychological; Male; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Saimiri; Theobromine; Theophylline; Xanthines | 1985 |
Phosphodiesterase-inhibiting properties of newer inotropic agents.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Milrinone; Myocardial Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridones; Theophylline | 1986 |
Methylisobutylxanthine blocks insulin antagonism of cAMP-stimulated glycogenolysis at a site distinct from phosphodiesterase. Evidence favoring an insulin-insensitive calcium release mechanism.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Calcium; Concanavalin A; Cyclic AMP; Glucose; Insulin; Lactates; Lactic Acid; Liver Glycogen; Male; Phenylephrine; Phenylisopropyladenosine; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Theophylline; Vasopressins | 1986 |
Response of rat small intestinal active aldohexose transport to elevation of mucosal cyclic AMP by forskolin and 3-isobutyl-1-methylxanthine in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Galactose; Glucose; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Male; Mice; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Water | 1985 |
Effects of drugs which influence noradrenergic activity on metenkephalin levels in specific brain areas.
Topics: 1-Methyl-3-isobutylxanthine; Amygdala; Animals; Brain Chemistry; Clonidine; Enkephalin, Methionine; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Synaptic Transmission; Thalamic Nuclei; Theophylline | 1986 |
Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenine Nucleotides; Adenosine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Immunoglobulin E; In Vitro Techniques; Male; Mast Cells; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Serotonin; Tachyphylaxis; Theophylline; Time Factors; Tubercidin | 1986 |
A1 and A2 adenosine receptors regulate adenylate cyclase in cultured human lung fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Line; Cyclic AMP; Fibroblasts; Humans; Lung; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Virulence Factors, Bordetella | 1986 |
The effects of phosphodiesterase inhibitors and lanthanum ions on the light-sensitive current of toad retinal rods.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adaptation, Physiological; Animals; Bufo marinus; Calcium; In Vitro Techniques; Lanthanum; Light; Photoreceptor Cells; Theophylline; Time Factors | 1986 |
Regulation of bovine sperm motility and cyclic adenosine 3',5'-monophosphate by adenosine and its analogues.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Bicarbonates; Cattle; Cyclic AMP; Dibucaine; Male; Sperm Motility; Spermatozoa; Structure-Activity Relationship; Theophylline | 1986 |
Antidiuretic effects of dibutyryl-cyclic AMP microinjected into the hypothalamic paraventricular nucleus in a water-loaded and ethanol-anesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Atropine; Blood Pressure; Bucladesine; Cyclic AMP; Diuresis; Dose-Response Relationship, Drug; Ethanol; Male; Microinjections; Osmotic Pressure; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred Strains; Tachyphylaxis; Theophylline | 1986 |
Cortisol at physiological concentrations and prostaglandin E2 are additive inhibitors of human natural killer cell activity.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Cyclic AMP; Cytotoxicity, Immunologic; Dinoprostone; Drug Synergism; Female; Humans; Hydrocortisone; In Vitro Techniques; Killer Cells, Natural; Male; Prostaglandins E; Theophylline | 1986 |
Influence of papaverine on cyclic nucleotide level and cellular metabolism in rat kidney cortex in terms of its inhibitory effect on p-aminohippurate transport.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aminohippuric Acids; Animals; Biological Transport; Calcium; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kidney Cortex; Male; Mitochondria; Nucleotides, Cyclic; Ouabain; Oxygen Consumption; p-Aminohippuric Acid; Papaverine; Rats; Rats, Inbred Strains; Sodium; Theophylline | 1986 |
Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Coronary Vessels; Structure-Activity Relationship; Theophylline | 1986 |
Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acids; Bucladesine; Cells, Cultured; Dinoprostone; Indomethacin; Interferon-gamma; Interleukin-1; Isoproterenol; Kinetics; Macrophages; Melitten; Mice; Mice, Inbred C3H; Prostaglandins E; Theophylline | 1986 |
Effects of perinatal administration of isobutyl methylxanthine (IBMX) on [3H]-DA binding in the forebrain of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Body Weight; Cyclic AMP; Diencephalon; Dopamine; Estrus; Female; Male; Motor Activity; Pregnancy; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sex Factors; Telencephalon; Theophylline | 1986 |
The mechanism of caffeine-enhanced glucose stimulation of liver glycogen synthase phosphatase activity.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Glucose; Glucose-6-Phosphate; Glucosephosphates; Liver; Male; Phosphoprotein Phosphatases; Rats; Structure-Activity Relationship; Theobromine; Theophylline; Time Factors; Xanthine; Xanthines | 1986 |
Adenosine induced immunosuppression: the role of the adenosine receptor--adenylate cyclase interaction in the alteration of T-lymphocyte surface phenotype and immunoregulatory function.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Adult; Antibodies, Monoclonal; Antigens, Surface; B-Lymphocytes; Cell Differentiation; Humans; Immune Tolerance; Isoproterenol; Kinetics; Receptors, Cell Surface; Receptors, Purinergic; T-Lymphocytes; Theophylline | 1986 |
Steroid regulation of the peptide-mediated increase in cyclic GMP in the nervous system of the hawkmoth, Manduca sexta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic GMP; Ganglia; Insect Hormones; Lepidoptera; Moths; Theophylline | 1985 |
Cardiac versus coronary vasodilator actions of isobutylmethylxanthine in dogs: comparison with theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrioventricular Node; Coronary Circulation; Coronary Vessels; Dogs; Female; Heart; Heart Rate; Male; Models, Biological; Myocardial Contraction; Theophylline; Vasodilation | 1986 |
Effects of cholera toxin and isobutylmethylxanthine on growth of human fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Cell Count; Cell Cycle; Cell Division; Cells, Cultured; Cholera Toxin; Cyclic AMP; Fibroblasts; Flow Cytometry; Humans; Platelet-Derived Growth Factor; Theophylline | 1986 |
Calcium-dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analogue.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Action Potentials; Adenosine; Adenylyl Cyclases; Animals; Baclofen; Calcium; Cells, Cultured; Depression, Chemical; Ganglia, Spinal; Ion Channels; Neurons; Potassium; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Theophylline | 1986 |
Effect of pentagastrin on gastric acid secretion in the totally isolated vascularly perfused rat stomach stimulated with the phosphodiesterase inhibitor isobutyl methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dose-Response Relationship, Drug; Gastric Acid; Gastric Fistula; Pentagastrin; Perfusion; Rats; Stomach; Theophylline | 1986 |
Mechanism of action of calcitonin gene-related peptide in stimulating pancreatic enzyme secretion.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Guinea Pigs; Male; Nerve Tissue Proteins; Pancreas; Peptide PHI; Peptides; Phosphodiesterase Inhibitors; Secretin; Species Specificity; Theophylline; Vasoactive Intestinal Peptide | 1986 |
Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Analgesia; Animals; Caffeine; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine; Naloxone; Nociceptors; Spinal Cord; Theophylline; Xanthines | 1986 |
Characteristics of high affinity and low affinity adenosine binding sites in human cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Cell Membrane; Cerebral Cortex; Humans; Kinetics; Phenylisopropyladenosine; Receptors, Purinergic; Theophylline | 1986 |
The in vitro effects of cyclic nucleotides, cyanoketone, and cycloheximide on the production of estradiol-17 beta by vitellogenic ovarian follicles of goldfish (Carassius auratus).
Topics: 1-Methyl-3-isobutylxanthine; Androstenols; Animals; Aromatase; Bucladesine; Chorionic Gonadotropin; Cyanoketone; Cyclic AMP; Cyclic GMP; Cycloheximide; Cyprinidae; Dibutyryl Cyclic GMP; Estradiol; Female; Goldfish; Nucleotides, Cyclic; Ovarian Follicle; Theophylline; Time Factors; Vitellogenesis | 1986 |
Cyclic AMP inhibits the release of prostaglandins and arachidonic acid from cultures of mouse embryo palate mesenchyme cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Cells, Cultured; Connective Tissue; Cyclic AMP; Embryo, Mammalian; Female; Isoproterenol; Kinetics; Male; Mesoderm; Mice; Mice, Inbred C57BL; Palate; Pregnancy; Prostaglandins; Theophylline | 1986 |
Therapeutic concentrations of theophylline and enprofylline potentiate catecholamine effects and inhibit leukocyte activation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Bucladesine; Calcimycin; Calcium; Catecholamines; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoproterenol; Middle Aged; Neutrophils; Prostaglandins E; Theophylline; Xanthines | 1986 |
Effect of chronically administered methylxanthines on ethanol-induced motor incoordination in mice.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Brain; Caffeine; Drug Synergism; Ethanol; Kinetics; Male; Mice; Motor Activity; Receptors, Purinergic; Theophylline; Xanthines | 1986 |
Agents that increase cellular cyclic AMP inhibit proliferative activity and decrease lipid content in cells cultured from atherosclerotic human aorta.
Topics: 1-Methyl-3-isobutylxanthine; Aorta; Arteriosclerosis; Bucladesine; Cell Division; Cholera Toxin; Cyclic AMP; Epoprostenol; Humans; In Vitro Techniques; Lipids; Theophylline; Thymidine | 1986 |
Reduced positive inotropic effects in diseased human ventricular myocardium.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Aged; Calcium; Dobutamine; Dopamine; Dose-Response Relationship, Drug; Female; Heart Diseases; Histamine; Humans; Isoproterenol; Male; Middle Aged; Milrinone; Myocardial Contraction; Myocardium; Pyridones; Stimulation, Chemical; Theophylline | 1986 |
Cyclic AMP levels in slices of epileptic cortex of the rat: effects of glutamate and 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cerebral Cortex; Cyclic AMP; Electroencephalography; Epilepsy; Ferrous Compounds; Glutamates; Glutamic Acid; Male; Rats; Rats, Inbred Strains; Theophylline | 1986 |
Comparative study of the effects of cyclic nucleotide phosphodiesterase inhibitors on bone resorption and cyclic AMP formation in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Bone and Bones; Bone Resorption; Calcium; Colforsin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Indomethacin; Kinetics; Lysosomes; Mice; Parathyroid Hormone; Prostaglandins E; Pyrrolidinones; Rolipram; Theophylline | 1986 |
ATP release from affinity-purified rat cholinergic nerve terminals.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Acetylcholine; Adenosine; Adenosine Triphosphate; Animals; Cholinergic Fibers; Chromatography, High Pressure Liquid; Potassium Chloride; Rats; Sheep; Theophylline; Veratridine | 1987 |
Discriminative stimulus properties of caffeine in the rat: noradrenergic mediation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adrenergic alpha-Antagonists; Animals; Apomorphine; Avoidance Learning; Caffeine; Clonidine; Diazepam; Discrimination Learning; Male; Norepinephrine; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1986 |
Effect of in vivo administration of 3-isobutyl 1-methyl xanthine (IBMX) on cyclic AMP levels, and DNA synthesis in Ehrlich ascites tumor cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carcinoma, Ehrlich Tumor; Cyclic AMP; DNA, Neoplasm; Male; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Theophylline | 1986 |
Effects of cyclic nucleotide derivatives on acetylcholine-induced secretion from isolated, perfused rat submandibular salivary glands.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bucladesine; Cyclic GMP; Isoproterenol; Male; Nucleotides, Cyclic; Rats; Rats, Inbred Strains; Saliva; Submandibular Gland; Theophylline | 1986 |
Adenosine receptors in post-mortem human cerebral cortex and the effect of carbamazepine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Binding, Competitive; Carbamazepine; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Phenylisopropyladenosine; Postmortem Changes; Receptors, Purinergic; Software; Theophylline | 1986 |
Involvement of cyclic AMP in vasodilatation by amrinone: a comparative study with 3-isobutyl-methyl-xanthine (IBMX).
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amrinone; Animals; Aorta; Cyclic AMP; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Potassium; Rabbits; Sulfonamides; Theophylline; Vasodilation | 1986 |
Insulin secretion and lysosomal enzyme activities in isolated mouse islets. Effects of glucose, diazoxide and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diazoxide; Female; Glucose; Glycoside Hydrolases; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Lysosomes; Mice; Mice, Inbred Strains; Theophylline | 1986 |
Methylxanthine bronchodilators potentiate multiple human neutrophil functions.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Aminophylline; Bronchodilator Agents; Cell Aggregation; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Receptors, Purinergic; Superoxides; Theophylline; Xanthines | 1987 |
Repetitive axonal discharges elicited by serotonin and intracellular adenosine 3',5'-cyclic monophosphate in the crayfish neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astacoidea; Axons; Colforsin; Cyclic AMP; Evoked Potentials; In Vitro Techniques; Neuromuscular Junction; Serotonin; Theophylline | 1986 |
Behavioral interactions of ethanol and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Posture; Psychomotor Performance; Reflex; Theophylline; Xanthines | 1987 |
Effect of temperature on atrial and ventricular adenosine A1 receptors of the guinea pig.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenylyl Cyclase Inhibitors; Animals; Guinea Pigs; Heart Atria; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Receptors, Purinergic; Temperature; Theophylline | 1986 |
Cyclic AMP and the vascular action of parathyroid hormone.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Blood Pressure; Bucladesine; Cyclic AMP; Dogs; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Parathyroid Hormone; Peptide Fragments; Rats; Teriparatide; Theophylline; Vasodilation | 1986 |
Effects of temperature on allosteric and catalytic properties of the cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cattle; Cyclic AMP; Cyclic GMP; Kinetics; Liver; Solvents; Temperature; Theophylline | 1987 |
Effects of enoximone and isobutylmethylxanthine on contractile tension and cyclic nucleotide levels in isolated blood-perfused dog papillary muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Enoximone; Imidazoles; In Vitro Techniques; Myocardial Contraction; Nucleotides, Cyclic; Papillary Muscles; Theophylline | 1987 |
Opposite regulatory effects of cAMP and cGMP on sugar uptake in rat thymocytes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Carbohydrate Metabolism; Cyclic AMP; Cyclic GMP; Deoxyglucose; Epinephrine; Female; Insulin; Osmolar Concentration; Rats; Rats, Inbred Strains; Theophylline; Thymus Gland; Triiodothyronine | 1987 |
Calcium ionophore-induced changes in HCO3- secretion and Cl- absorption in turtle bladder: relation to action of 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Absorption; Animals; Anions; Bicarbonates; Calcimycin; Calcium; Chlorides; Cyclic AMP; Cytosol; Theophylline; Turtles; Urinary Bladder | 1987 |
Cyclic adenosine-3',5'-monophosphate stimulates the acute release of placental lactogen from human trophoblast cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Bucladesine; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Female; Humans; Kinetics; Placental Lactogen; Pregnancy; Theophylline; Trophoblasts | 1987 |
Lithium ion reversibly inhibits inducer-stimulated adipose conversion of 3T3-L1 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Calcimycin; Cations; Cell Differentiation; Cell Line; Chlorides; Contact Inhibition; Dexamethasone; Fibroblasts; Glycerolphosphate Dehydrogenase; Insulin Antagonists; Lipid Metabolism; Lithium; Lithium Chloride; Mice; Monensin; Ouabain; Theophylline | 1987 |
Relation of prostaglandin-induced increases in cellular cAMP to stimulation of pepsinogen secretion from dispersed chief cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Male; Pepsinogens; Prostaglandins; Prostaglandins A; Prostaglandins B; Prostaglandins E; Prostaglandins F; Stomach; Theophylline | 1987 |
In vivo regulation of cyclic AMP phosphodiesterase in Xenopus oocytes. Stimulation by insulin and insulin-like growth factor 1.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; Female; Insulin; Insulin-Like Growth Factor I; Kinetics; Microinjections; Oocytes; Progesterone; Somatomedins; Theophylline; Xenopus | 1987 |
Further characterization of the slow muscarinic responses in Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Calcium; Chlorides; Evoked Potentials; Female; In Vitro Techniques; Ion Channels; Microbial Collagenase; Oocytes; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium; Receptors, Muscarinic; Theophylline; Xenopus laevis | 1987 |
Effects of alkylxanthines and calcium antagonists on adenosine uptake by cultured rabbit coronary microvascular endothelium.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Dipyridamole; Endothelium; Ethanol; Isoproterenol; Male; Microcirculation; Rabbits; Theophylline; Trifluoperazine; Xanthines | 1987 |
Interaction of phosphodiesterase inhibitors triamterene, papaverine, theophylline, IBMX and amrinone with other positive inotropic acting substances on isolated guinea-pig atria.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Colforsin; Drug Interactions; Electric Stimulation; Guinea Pigs; Heart Rate; Histamine; In Vitro Techniques; Male; Metaproterenol; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Stimulation, Chemical; Theophylline; Triamterene | 1987 |
Cyclic AMP-regulating agents inhibit endotoxin-mediated cartilage degradation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cartilage; Cattle; Colforsin; Culture Techniques; Cyclic AMP; Dose-Response Relationship, Drug; Endotoxins; Proteoglycans; Theophylline | 1987 |
Effect of forskolin, isoproterenol and IBMX on angiotensin converting enzyme and cyclic AMP production by cultured bovine endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Isoproterenol; Kinetics; Peptidyl-Dipeptidase A; Theophylline | 1987 |
Dissociation of neutrophil aggregation, adhesiveness, and Fc receptor activity.
Topics: 1-Methyl-3-isobutylxanthine; Cell Adhesion; Cell Aggregation; Cholera Toxin; Cyclic AMP; Humans; Immunoglobulin G; Isoproterenol; Neutrophils; Prostaglandins E; Receptors, Fc; Receptors, IgG; Rosette Formation; Theophylline | 1987 |
Measurement of antagonist affinity for purine receptors of drugs producing concomitant phosphodiesterase blockade: the use of pharmacologic resultant analysis.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heart; In Vitro Techniques; Male; Phosphodiesterase Inhibitors; Purines; Rats; Rats, Inbred Strains; Receptors, Purinergic; Regression Analysis; Theophylline; Vas Deferens | 1987 |
Stimulation of acetylcholine release from myenteric neurons of guinea pig small intestine by forskolin and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Bucladesine; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Intestine, Small; Muscle Contraction; Myenteric Plexus; Theophylline | 1987 |
Comparison of vasodilator effects of DN-9693, a selective inhibitor of cyclic AMP phosphodiesterase, and isobutylmethylxanthine, a non-selective one, in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antineoplastic Agents; Coronary Circulation; Dogs; Female; Femur; Male; Myocardium; Oxygen Consumption; Quinazolines; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Theophylline; Vasodilator Agents | 1987 |
Attenuation of isobutylmethylxanthine-induced suppression of operant behavior by pretreatment of rats with clonidine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clonidine; Conditioning, Operant; Male; Narcotics; Rats; Rats, Inbred Strains; Reinforcement Schedule; Substance Withdrawal Syndrome; Theophylline | 1987 |
Methylisobutylxanthine, a potent inhibitor of cAMP phosphodiesterase, enhances the sensitivity of Chinese hamster ovary cells to mitomycin C.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bucladesine; Cell Survival; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Interphase; Mitomycin; Mitomycins; Theophylline | 1987 |
Epidermal growth factor stimulates formation of inositol phosphates in BALB/c/3T3 cells pretreated with cholera toxin and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cholera Toxin; Cycloheximide; Epidermal Growth Factor; Inositol Phosphates; Mice; Mice, Inbred BALB C; Platelet-Derived Growth Factor; Sugar Phosphates; Theophylline | 1988 |
Membrane currents elicited by porcine vasoactive intestinal peptide (VIP) in follicle-enclosed Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Female; In Vitro Techniques; Membrane Potentials; Oocytes; Peptide PHI; Potassium; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Swine; Theophylline; Vasoactive Intestinal Peptide; Xenopus laevis | 1987 |
Characterization of rat preadipocytes from normal rat adipose tissue by their effector response.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Centrifugation, Density Gradient; Dexamethasone; Glycerolphosphate Dehydrogenase; Hemin; Insulin; Rats; Theophylline | 1987 |
Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Angiotensin II; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; In Vitro Techniques; Intracellular Fluid; Liver; Male; Rats; Rats, Inbred Strains; Theophylline | 1988 |
Decreased contractile response after exposure of the rat aorta to Db cAMP or IBMX.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Bucladesine; Calcimycin; Calcium Chloride; Cyclic AMP; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Theophylline | 1987 |
cAMP elevation modulates physiological activity of pyloric neurons in the lobster stomatogastric ganglion.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Digestive System; Ganglia; In Vitro Techniques; Models, Neurological; Nephropidae; Neurons; Theophylline | 1987 |
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Catechol Oxidase; DNA; Gene Expression Regulation; Glycoproteins; Humans; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Neoplasm Proteins; Pigmentation; Species Specificity; Theophylline; Tumor Cells, Cultured | 1987 |
Effects of methylxanthines on cell-cycle redistribution and sensitization to killing by low-dose-rate radiation.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cell Cycle; Cell Survival; Humans; Radiation Dosage; Radiation Tolerance; Theophylline; Tumor Cells, Cultured | 1988 |
Effects of IBMX on the ERG of the isolated perfused cat eye.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Electroretinography; In Vitro Techniques; Photometry; Photoreceptor Cells; Retina; Theophylline; Time Factors | 1987 |
Differences in the cyclic nucleotide mediation of luteinizing hormone-releasing hormone action on the rat and hamster anterior pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cricetinae; Cyclic GMP; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; In Vitro Techniques; Kinetics; Luteinizing Hormone; Male; Mesocricetus; Pituitary Gland, Anterior; Rats; Species Specificity; Theophylline | 1988 |
3':5'-cyclic GMP in the yeast Saccharomyces cerevisiae at different metabolic conditions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Cyclic AMP; Cyclic GMP; Glucose; Guanosine Triphosphate; Oxygen; Radioimmunoassay; Saccharomyces cerevisiae; Theophylline | 1988 |
Effects of caffeine and 3-isobutyl 1-methyl xanthine on caprine milk secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Fats; Female; Goats; Infusions, Intravenous; Injections, Intramuscular; Lactation; Milk; Milk Proteins; Pregnancy; Theophylline | 1988 |
Alkali secretion in the turtle bladder: up-regulation by the phospho-inositol cascade and inhibition by diphenylamine carboxylate (DPC).
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carbachol; Choline; Cyclic AMP; Hydrogen-Ion Concentration; ortho-Aminobenzoates; Phosphatidylinositols; Theophylline; Turtles; Urinary Bladder; Vasoactive Intestinal Peptide | 1988 |
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Colforsin; Cyclic AMP; Electric Conductivity; Enzyme Activation; Ion Channels; Kinetics; Pheochromocytoma; Potassium; Theophylline; Tumor Cells, Cultured | 1988 |
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cholera Toxin; Colforsin; Cyclic AMP; Evoked Potentials; Fluorides; In Vitro Techniques; Mice; Neuromuscular Junction; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Theophylline | 1988 |
Use of pharmacologic antagonists to deduce commonalities of biologic activity among clostridial neurotoxins.
Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; Acetylcholine; Amifampridine; Aminopyridines; Ammonium Chloride; Animals; Botulinum Toxins; Calcium; Cholera Toxin; Colforsin; Female; Guanidine; Guanidines; In Vitro Techniques; Methylamines; Mice; Neuromuscular Junction; Neurotoxins; Tetanus Toxin; Theophylline | 1988 |
Altered effect of BAY K 8644 after exposure of the rat aorta to IBMX or Db cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Bucladesine; Cyclic AMP; Dihydropyridines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Theophylline | 1988 |
Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenosine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Papillary Muscles; Phenylisopropyladenosine; Theophylline | 1988 |
Regulation of human natural cytotoxicity by IgG. II. Cyclic AMP as a mediator of monomeric IgG-induced inhibition of natural killer cell activity.
Topics: 1-Methyl-3-isobutylxanthine; Cyclic AMP; Cytotoxicity, Immunologic; Dinoprostone; Drug Synergism; Humans; Immunoglobulin G; Immunosuppressive Agents; Intracellular Fluid; Killer Cells, Natural; Phosphodiesterase Inhibitors; Prostaglandins E; Theophylline | 1988 |
Calcium dependence of rhythmic contractions of the Oryzias latipes blastoderm.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blastoderm; Bucladesine; Caffeine; Calcium; Calcium Channel Blockers; Cyprinodontiformes; Oryzias; Papaverine; Theophylline | 1988 |
Involvement of cyclic-AMP in the hypotensive response to fenoldopam but not to quinpirole in the anaesthetized rat.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Anesthesia; Animals; Benzazepines; Blood Pressure; Cyclic AMP; Ergolines; Fenoldopam; Histamine; Male; Quinpirole; Rats; Rats, Inbred Strains; Theophylline; Vasodilator Agents | 1988 |
Modulation of cyclic AMP and autoregulation of renal blood flow, analysed by the use of forskolin and 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dimethyl Sulfoxide; Dogs; Female; Male; Renal Circulation; Theophylline | 1988 |
Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine Triphosphate; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Theophylline; Virulence Factors, Bordetella | 1988 |
Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Blood Platelets; Dose-Response Relationship, Drug; Humans; Milrinone; Platelet Aggregation Inhibitors; Pyridones; Quinazolines; Theophylline | 1988 |
Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Caffeine; Calcium; In Vitro Techniques; Male; Mice; Motor Activity; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship; Theophylline | 1988 |
Differential actions of phosphodiesterase inhibitors on secretin- and vasoactive intestinal peptide-induced increases in chief cell cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Kinetics; Models, Biological; Phosphodiesterase Inhibitors; Secretin; Theophylline; Vasoactive Intestinal Peptide | 1988 |
On the adenosine receptor and adenosine inactivation at the rat diaphragm neuromuscular junction.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Diaphragm; Evoked Potentials; Female; In Vitro Techniques; Male; Motor Endplate; Muscle Contraction; Neuromuscular Junction; Rats; Rats, Inbred Strains; Receptors, Purinergic; Temperature; Theophylline | 1988 |
The effects of 3-isobutyl-methyl-xanthine on experimentally induced ocular inflammation in the rabbit.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aqueous Humor; Ascorbic Acid; Dinoprostone; Eye Proteins; Immune System Diseases; Leukocyte Count; Pregnenediones; Prostaglandins E; Rabbits; Serum Albumin; Theophylline; Uveitis, Anterior | 1988 |
Methylxanthine inhibitors of phosphodiesterases.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Coronary Vessels; Kinetics; Phosphodiesterase Inhibitors; Structure-Activity Relationship; Swine; Theophylline; Xanthines | 1988 |
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Imidazoles; Indomethacin; Peptidyl-Dipeptidase A; Propranolol; Theophylline; Trifluoperazine; Verapamil; Xanthines | 1988 |
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Assay; Bucladesine; Cyclic AMP; Dinoprostone; Lipopolysaccharides; Mice; Pentoxifylline; Theobromine; Theophylline; Tumor Necrosis Factor-alpha | 1988 |
Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetates; Animals; Arginine Vasopressin; Arteries; Cyclic AMP; Endothelium, Vascular; Guanosine Monophosphate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Reference Values; Tail; Theophylline | 1988 |
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclases; Animals; Bone Resorption; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Hydrocortisone; Indomethacin; Meclofenamic Acid; Mice; Mice, Inbred Strains; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Skull; Theophylline | 1988 |
A similar pool of cyclic AMP phosphodiesterase in Xenopus oocytes is stimulated by insulin, insulin-like growth factor 1, and [Val12,Thr59]Ha-ras protein.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Female; In Vitro Techniques; Insulin; Insulin-Like Growth Factor I; Kinetics; Membrane Proteins; Microinjections; Oocytes; Papaverine; Progesterone; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Somatomedins; Theophylline; Threonine; Valine; Xenopus | 1989 |
Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Locus Coeruleus; Male; Membrane Potentials; Neurons; Rats; Reference Values; Theophylline | 1987 |
Morphine blocks and naloxone enhances suppression of operant behavior by low doses of 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Body Temperature; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1989 |
Antigen-induced contraction of guinea-pig isolated trachea: studies with novel inhibitors and antagonists of arachidonic acid metabolites.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acids; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Isoproterenol; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Muscle, Smooth; Ovalbumin; Phosphodiesterase Inhibitors; Pyrilamine; Theophylline; Thromboxane-A Synthase; Trachea | 1988 |
Attenuation of endotoxin-induced cytotoxicity and prostacyclin production in cultured bovine pulmonary artery endothelial cells by phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Adenylyl Cyclases; Animals; Bucladesine; Cattle; Cell Survival; Cells, Cultured; Colforsin; Cyclic GMP; Endothelium, Vascular; Ferricyanides; L-Lactate Dehydrogenase; Lipopolysaccharides; Nitroprusside; Phosphodiesterase Inhibitors; Pulmonary Artery; Theophylline | 1988 |
Cyclic nucleotides and the rapid inhibitions of bone 45Ca uptake in response to bovine parathyroid hormone and 16,16-dimethyl prostaglandin E2 in chicks.
Topics: 1-Methyl-3-isobutylxanthine; 16,16-Dimethylprostaglandin E2; Animals; Bone and Bones; Bucladesine; Caffeine; Calcium; Calcium Radioisotopes; Chickens; Cyclic AMP; Male; Nucleotides, Cyclic; Parathyroid Hormone; Peptide Fragments; Prostaglandins E, Synthetic; Theophylline | 1989 |
Determination of 1,3-dimethyl-7-isobutylxanthine in guinea pig plasma by high-performance liquid chromatography.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chromatography, High Pressure Liquid; Guinea Pigs; Male; Spectrophotometry, Ultraviolet; Theophylline | 1988 |
The effect of cyclic AMP on neuritic outgrowth in explant cultures of developing chick olfactory epithelium.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Axons; Bucladesine; Chick Embryo; Colforsin; Cyclic AMP; Epithelial Cells; Neurons; Nose; Organ Culture Techniques; Theophylline | 1988 |
Effect of cAMP on ciliary function in rabbit tracheal epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cilia; Colforsin; Cyclic AMP; Epithelium; Furosemide; Kinetics; Male; Organ Culture Techniques; Rabbits; Theophylline; Thionucleotides; Trachea | 1989 |
Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Insulin; Insulin-Like Growth Factor I; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Somatomedins; Suramin; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Effects of DN-9693, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cholecystokinin; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Male; Pancreas; Pancreatic Juice; Papaverine; Phentolamine; Phosphodiesterase Inhibitors; Propranolol; Quinazolines; Secretin; Sulpiride; Theophylline | 1989 |
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Cell Membrane; Colforsin; Cricetinae; Cyclic AMP; Epinephrine; Genes; Glioma; Kinetics; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Tetradecanoylphorbol Acetate; Theophylline; Transcription, Genetic | 1989 |
The modulation of the ionic selectivity of the light-sensitive current in isolated rods of the tiger salamander.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Ambystoma; Animals; Calcium; Cations, Divalent; In Vitro Techniques; Ion Channels; Light; Photoreceptor Cells; Sodium; Theophylline; Time Factors | 1988 |
Identification of an adenosine 3',5'-monophosphate (cAMP)-responsive region in the rat growth hormone gene: evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chromosome Deletion; Colforsin; Cyclic AMP; Drug Synergism; Gene Expression Regulation; Genes; Growth Hormone; Molecular Sequence Data; Promoter Regions, Genetic; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Theophylline; Thionucleotides; Transcription, Genetic; Triiodothyronine | 1989 |
Effect of isoproterenol and 3-isobutyl-1-methylxanthine on junctional conductance in heart cell pairs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Electric Conductivity; Heart Conduction System; Heart Ventricles; Intercellular Junctions; Isoproterenol; Membrane Potentials; Protein Kinase Inhibitors; Rats; Theophylline; Ventricular Function | 1989 |
The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cerebral Cortex; In Vitro Techniques; Kinetics; Male; Myocardium; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Purinergic; Theophylline; Thioinosine; Xanthines | 1989 |
Increased cyclic AMP content accelerates protein synthesis in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Glucagon; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Myocardial Contraction; Myocardium; Perfusion; Phenylalanine; Protein Biosynthesis; Protein Kinases; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1989 |
Tissue selective inhibition of cyclic nucleotide phosphodiesterase by denbufylline.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic AMP; Organ Specificity; Rats; Theophylline; Xanthines | 1989 |
Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; DNA; Fibroblasts; Gene Expression Regulation; Genes; Genetic Vectors; Homeostasis; Humans; Isoproterenol; Kinetics; Mutation; Phosphorylation; Receptors, Adrenergic, beta; RNA, Messenger; Theophylline; Transcription, Genetic; Transfection | 1989 |
On the transduction mechanism of microvillar photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic GMP; Dark Adaptation; Invertebrates; Ion Channels; Membrane Potentials; Microvilli; Phosphorylation; Photoreceptor Cells; Signal Transduction; Theophylline | 1989 |
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; Clone Cells; Colforsin; Cyclic AMP; Down-Regulation; GTP-Binding Proteins; Kinetics; Osteosarcoma; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Rats; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Teriparatide; Theophylline; Virulence Factors, Bordetella | 1989 |
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alprostadil; Bucladesine; Carbachol; Cholera Toxin; Colforsin; Cyclic AMP; Humans; Intracellular Membranes; Ligands; Neuroblastoma; Phosphatidylinositols; Receptors, Muscarinic; Theophylline; Tumor Cells, Cultured | 1989 |
A study of the phasic response of arterioles of the guinea pig small intestine to prolonged exposure to norepinephrine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arterioles; Clonidine; Colforsin; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Intestine, Small; Isoproterenol; Membrane Potentials; Norepinephrine; Oxidation-Reduction; Propranolol; Temperature; Theophylline; Vasoconstriction; Yohimbine | 1989 |
Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Carbamates; Cardiovascular Agents; Cyclic AMP; Cyclic GMP; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Rabbits; Theophylline | 1989 |
Comparison of the effects of isobutylmethylxanthine and milrinone on ischaemia-induced arrhythmias and platelet aggregation in anaesthetized rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Cardiotonic Agents; Coronary Disease; Electrocardiography; Heart Rate; Male; Milrinone; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Rabbits; Theophylline | 1989 |
Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carrier Proteins; Cell Line; Cyclic AMP; Enzyme Inhibitors; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Peptide Fragments; Plasmids; Protein Kinases; Tetradecanoylphorbol Acetate; Theophylline; Transcription, Genetic; Transfection | 1989 |
Agents affecting adenylate cyclase activity modulate the stimulatory action of 1,25-dihydroxyvitamin D3 on the production of osteocalcin by human bone cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaline Phosphatase; Bone and Bones; Bucladesine; Calcitriol; Cells, Cultured; Colforsin; Humans; Interleukin-1; Kinetics; Osteoblasts; Osteocalcin; Phorbols; Recombinant Proteins; Theophylline | 1989 |
Inhibitory effect of cyclic AMP on phorbol ester-stimulated production of reactive oxygen metabolites in rat glomeruli.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Kidney Glomerulus; Kinetics; Luminescent Measurements; Male; Oxygen; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kinetics; Male; Methylene Blue; Muscle Relaxants, Central; Nitric Oxide; Phthalazines; Purinones; Pyridazines; Rats; Rats, Inbred Strains; Theophylline; Vinca Alkaloids | 1989 |
Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Calmodulin; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Cytosol; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Theophylline | 1989 |
Effects of N6,2'-O-dibutyryladenosine 3',5'-cyclic monophosphate, adenosine, and of oxotremorine and 3-isobutyl-1-methylxanthine on the electrically evoked [3H]acetylcholine secretion in the guinea-pig ileum myenteric plexus.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Bucladesine; Electric Stimulation; Guinea Pigs; Ileum; Myenteric Plexus; Oxotremorine; Physostigmine; Receptors, Muscarinic; Theophylline | 1989 |
Studies on modified nucleic acid bases: structure of 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Molecular Structure; Theophylline; X-Ray Diffraction | 1988 |
Membrane currents elicited by prostaglandins, atrial natriuretic factor and oxytocin in follicle-enclosed Xenopus oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atrial Natriuretic Factor; Cell Separation; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Membrane Potentials; Oocytes; Ovarian Follicle; Oxytocin; Prostaglandins; Theophylline; Xenopus laevis | 1989 |
Inhibition by salbutamol, forskolin and IBMX of AlF4-induced inositol phosphate formation in bovine airway smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Albuterol; Aluminum; Aluminum Compounds; Animals; Cattle; Colforsin; Fluorides; In Vitro Techniques; Inositol Phosphates; Muscle, Smooth; Theophylline; Trachea | 1989 |
A comparison of the inotropic activity of Org 30029, IBMX, milrinone and rolipram in rat papillary muscles.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cardiotonic Agents; In Vitro Techniques; Milrinone; Myocardial Contraction; Organic Chemicals; Papillary Muscles; Pyridones; Pyrrolidinones; Rats; Rolipram; Theophylline | 1989 |
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Conditioning, Operant; Dose-Response Relationship, Drug; Injections, Intramuscular; Injections, Intravenous; Male; Psychomotor Performance; Reinforcement Schedule; Saimiri; Stimulation, Chemical; Theophylline | 1989 |
Potentiation of the effects of dopamine in the rabbit isolated splenic artery by 3-isobutyl-1-methylxanthine or forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Benzopyrans; Colforsin; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Parasympatholytics; Purinergic Antagonists; Purinones; Pyrroles; Rabbits; Splenic Artery; Theophylline | 1989 |
Anion channels in a leaky epithelium. A patch-clamp study of choroid plexus.
Topics: 1-Methyl-3-isobutylxanthine; 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Anions; Bucladesine; Chloride Channels; Chlorides; Choroid Plexus; Electric Conductivity; Epithelium; Furosemide; Ion Channel Gating; Membrane Potentials; Membrane Proteins; Necturus maculosus; Osmolar Concentration; Theophylline | 1989 |
[The relationship between the intracellular content of 1-methyl-3-isobutylxanthine and the permeability for water of the bladder wall in the frog].
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cell Membrane Permeability; Cyclic AMP; Dose-Response Relationship, Drug; Osmosis; Rana temporaria; Theophylline; Tritium; Urinary Bladder; Water | 1989 |
Inhibition of porcine adipose tissue lipogenesis by beta-adrenergic agonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Adrenergic beta-Agonists; Animals; Caffeine; Drug Interactions; Epinephrine; Isoproterenol; Lipids; Male; Propranolol; Swine; Theophylline | 1989 |
Influence of isobutylmethylxanthine on the direct current electroretinogram of albino rabbit eyes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dark Adaptation; Electrophysiology; Electroretinography; Pigment Epithelium of Eye; Rabbits; Retina; Theophylline; Vitrectomy | 1989 |
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animals; Biopterins; Cell Line; Colforsin; Cycloheximide; Dihydropteridine Reductase; GTP Cyclohydrolase; Isoenzymes; Kinetics; Pheochromocytoma; Pteridines; Pterins; Rats; Reserpine; Theophylline | 1989 |
Arachidonic acid metabolism in cultured aortic endothelial cells. Effect of cAMP and 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Endothelium; Epoprostenol; Muscle, Smooth, Vascular; Swine; Theophylline | 1985 |
Perifusion of a clonal cell line of Simian virus 40-transformed beta cells. Insulin secretory dynamics in response to glucose, 3-isobutyl-1-methylxanthine, and potassium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Membrane; Cell Transformation, Viral; Cells, Cultured; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Potassium; Simian virus 40; Theophylline | 1985 |
Mechanism of the inhibitory action of dopamine and somatostatin on prolactin secretion from human lactotrophs in culture.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma; Adolescent; Adult; Calcimycin; Calcium; Cells, Cultured; Cyclic AMP; Dopamine; Female; Humans; Male; Middle Aged; Pituitary Gland, Anterior; Pituitary Neoplasms; Potassium; Prolactin; Radioimmunoassay; Somatostatin; Theophylline | 1985 |
Control of secretion vesicle margination and lysis by glucose, IBMX, and glyburide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Calmodulin; Cell Membrane; Cytoplasmic Granules; Exocytosis; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin; Stimulation, Chemical; Theophylline; Trifluoperazine | 1985 |
Occurrence of the methylisobutylxanthine-stimulated cyclic GMP binding protein in various rat tissues.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Brain Chemistry; Carrier Proteins; Chromatography, Ion Exchange; Intracellular Signaling Peptides and Proteins; Lung; Male; Rats; Rats, Inbred Strains; Spleen; Theophylline; Tissue Distribution | 1985 |
Methyl xanthines enhance taste: evidence for modulation of taste by adenosine receptor.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adult; Animals; Caffeine; Female; Humans; In Vitro Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Taste; Theobromine; Theophylline; Xanthines | 1985 |
Dopamine inhibits forskolin- and 3-isobutyl-1-methylxanthine-induced dark-adaptive retinomotor movements in isolated teleost retinas.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Dark Adaptation; Diterpenes; Dopamine; Fishes; In Vitro Techniques; Pigment Epithelium of Eye; Retina; Theophylline | 1985 |
Involvement of calcium in the release of immunoreactive beta-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Endorphin; Bucladesine; Calcimycin; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Endorphins; In Vitro Techniques; Isoproterenol; Pituitary Gland; Rats; Theophylline; Verapamil | 1985 |
Endogenous adenosine as a modulator of hippocampal acetylcholine release.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Caudate Nucleus; Dipyridamole; Electric Stimulation; Hippocampus; In Vitro Techniques; Pyrrolidinones; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Rolipram; Theophylline | 1984 |
Beta-adrenergic receptor mechanisms in rat parotid glands: activation by nerve stimulation and 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Amylases; Animals; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Isoproterenol; Male; Parotid Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Theophylline | 1984 |
[Adenosine-3',5'-monophosphate content and muscle tension in isolated coronary arteries under the effect of lanthanum ions].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Coronary Vessels; Cyclic AMP; In Vitro Techniques; Isoflurophate; Isoproterenol; Lanthanum; Muscle Contraction; Muscle, Smooth, Vascular; Papaverine; Theophylline; Trapidil | 1984 |
Influence of isoproterenol and methylisobutylxanthine on the contractile and cyclic nucleotide effects of methacholine in isolated rat atria.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Cyclic GMP; Depression, Chemical; Drug Interactions; Female; Heart Atria; In Vitro Techniques; Isoproterenol; Methacholine Compounds; Myocardial Contraction; Ouabain; Rats; Stimulation, Chemical; Theophylline | 1980 |
Stimulation of insulin release in the absence of extracellular calcium by isobutylmethylxanthine and its inhibition by somatostatin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Egtazic Acid; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Rats; Somatostatin; Theophylline | 1980 |
Studies of Schwann cell proliferation. III. Evidence for the surface localization of the neurite mitogen.
Topics: 1-Methyl-3-isobutylxanthine; Axons; Cell Division; Cell Membrane; Culture Techniques; Cyclic AMP; Cytoplasm; Ganglia, Spinal; Mitogens; Schwann Cells; Theophylline; Trypsin | 1980 |
Inhibitors of epidermal cell DNA synthesis in surviving pig skin in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cell Division; Cyclic AMP; DNA; Epidermal Cells; Epidermis; Epinephrine; Histamine; Hydroxyurea; In Vitro Techniques; Swine; Theophylline | 1980 |
Effects of isoprenaline and 1-methyl-3-isobutylxanthine on cyclic nucleotides and cyclic AMP-dependent protein kinase in rabbit colon smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colon; Cyclic AMP; Cyclic GMP; Isoproterenol; Muscle, Smooth; Protein Kinases; Rabbits; Sodium Fluoride; Theophylline | 1980 |
Interactions between catecholamines, methyl xanthines and adenosine in regulation of cyclic AMP accumulation in hamster adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Caffeine; Catecholamines; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Mesocricetus; Norepinephrine; Phentolamine; Theophylline | 1980 |
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Female; Lung Neoplasms; Male; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Theophylline | 1980 |
Development of the rat oocyte in vitro: inhibition and induction of maturation in the presence or absence of the cumulus oophorus.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Butyrates; Cholera Toxin; Cyclic AMP; Female; Follicle Stimulating Hormone; Gonadotropins; Granulosa Cells; In Vitro Techniques; Luteinizing Hormone; Oocytes; Ovum; Rats; Theophylline | 1980 |
The effects of beta-sympathomimetic amines and phosphodiesterase inhibitors on electrophysiological parameters in Purkinje fibres.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Cattle; Dose-Response Relationship, Drug; Heart Conduction System; Isoproterenol; Membrane Potentials; Purkinje Fibers; Theophylline | 1980 |
Activation of human lymphocyte high affinity cyclic AMP phosphodiesterase by culture with 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adult; Azides; Cyclic AMP; Cyclic GMP; Cycloheximide; Dactinomycin; Enzyme Activation; Humans; Kinetics; Lymphocytes; Theophylline | 1980 |
Inhibition of bone resorption and lysosomal enzyme release from calvarial bones cultured for 24 hours: synergism between cyclic AMP analogues and phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone and Bones; Bone Resorption; Bucladesine; Calcium; Cyclic AMP; Drug Synergism; Lysosomes; Mice; Organ Culture Techniques; Parathyroid Hormone; Phosphodiesterase Inhibitors; Theophylline; Time Factors | 1980 |
Enhancement by 3-isobutyl-1-methylxanthine and cholera toxin of 12-O-tetradecanoylphorbol-13-acetate-stimulated cyclic nucleotide levels and ornithine decarboxylase activity in isolated epidermal cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cell Separation; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclic GMP; Epidermis; Mice; Nucleotides, Cyclic; Ornithine Decarboxylase; Phorbols; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1980 |
Prevention of phorbol ester-induced catecholamine refractoriness by inhibitors of protein and RNA biosynthesis in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catecholamines; Cyclic AMP; Cycloheximide; Female; Fluorides; Isoproterenol; Kinetics; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline | 1980 |
Role of Ca2+ and cyclic nucleotides in the control of prostaglandin E production in the rat anterior pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acids; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Growth Hormone; In Vitro Techniques; Male; Pituitary Gland, Anterior; Potassium; Prostaglandins E; Rats; Theophylline | 1980 |
Effects of mammalian LH, cyclic AMP and phosphodiesterase inhibitors on steroidogenesis, lactate production, glucose uptake and utilization by avian granulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Chickens; Female; Glucose; Granulosa Cells; Lactates; Luteinizing Hormone; Papaverine; Phosphodiesterase Inhibitors; Progesterone; Sheep; Theophylline | 1980 |
Studies on the mechanism of action of glucagon in strips of rabbit renal artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil | 1980 |
Inhibition of cyclic AMP phosphodiesterase activity and myocardial contractility: effects of cilostamide, a novel PDE inhibitor, and methylsiobutylxanthine on rabbit and canine ventricular muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Dogs; Female; Heart Rate; Isoproterenol; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phosphodiesterase Inhibitors; Quinolines; Quinolones; Rabbits; Theophylline | 1980 |
Sugar transport asymmetry in human erythrocytes--the effect of bulk haemoglobin removal and the addition of methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport; Cyclic AMP; Erythrocyte Membrane; Erythrocytes; Glucose; Hemoglobins; Humans; Kinetics; Theophylline | 1980 |
Alteration of neuronal activity in response to cyclic nucleotide agents in Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Aplysia; Cyclic AMP; Electrophysiology; Guanylyl Imidodiphosphate; In Vitro Techniques; Neurons; Nucleotides, Cyclic; Theophylline | 1980 |
Inhibition by purine compounds of cyclic GMP-stimulated cyclic AMP phosphodiesterase activity from a particulate fraction of rat striatum.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Hypoxanthines; Inosine; Male; Purines; Rats; Theophylline | 1980 |
Cyclic adenosine-3',5'-monophosphate stimulates islet B cell replication in neonatal rat pancreatic monolayer cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Cell Survival; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Theophylline | 1980 |
Hormone, serum, and methylxanthine interactions in the regulation of DNA synthesis in organ-cultured rat mammary tumors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Culture Techniques; Cyclic AMP; DNA, Neoplasm; Female; Growth Hormone; Hormones; Male; Mammary Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Prolactin; Rats; Theophylline | 1980 |
Muscarinic antagonism of the effects of phosphodiesterase inhibitor (methylisobutylxanthine) in embryonic chick ventricle.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Action Potentials; Animals; Calcium; Chick Embryo; Cyclic AMP; Heart; Isoproterenol; Muscarine; Myocardial Contraction; Myocardium; Phosphoric Diester Hydrolases; Theophylline | 1980 |
Calcium movements in relation to glucose-stimulated insulin secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Calcium; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Obese; Models, Biological; Subcellular Fractions; Theophylline | 1980 |
Fluorescent probing of calcium ions in islet cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbohydrates; Cations; Chlortetracycline; Fluorescence Polarization; Fluorescent Dyes; Islets of Langerhans; Mice; Mice, Obese; Microscopy, Fluorescence; Models, Molecular; Theophylline | 1980 |
Methylxanthines modulate adenosine release from slices of cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine Triphosphatases; Aminophylline; Animals; Caffeine; Cerebral Cortex; Cyclic AMP; gamma-Aminobutyric Acid; Male; Mice; Ouabain; Theophylline; Xanthines | 1981 |
Effects of 1-methyl-3-isobutyl xanthine (MIX) on amphibian neuromyal transmission.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Action Potentials; Animals; In Vitro Techniques; Neuromuscular Junction; Rana pipiens; Sciatic Nerve; Synaptic Transmission; Theophylline | 1980 |
Effect of thyroid hormone on cyclic AMP phosphodiesterase in rat kidney.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Hypothyroidism; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Papaverine; Rats; Theophylline; Thyroxine; Triiodothyronine | 1980 |
Negative inotropic effect of vanadate in ventricular myocardium in the presence of 3-isobutyl-1-methylxanthine or isoprenaline.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Isoproterenol; Membrane Potentials; Myocardial Contraction; Myocardium; Ouabain; Phosphoric Diester Hydrolases; Theophylline; Vanadates; Vanadium | 1980 |
Character and meaning of quasi-morphine withdrawal phenomena elicited by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Caffeine; Humans; Hypoxanthines; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Pyrimidines; Rats; Substance Withdrawal Syndrome; Theobromine; Theophylline; Triazoles; Xanthines | 1981 |
Phosphodiesterase inhibitors facilitate memory for passive avoidance conditioning.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Avoidance Learning; Cyclic AMP; Electroshock; Foot; Imidazoles; Male; Memory; Mice; Mice, Inbred ICR; Phosphodiesterase Inhibitors; Reaction Time; Retention, Psychology; Theophylline | 1981 |
Methylxanthine effects on cyclic adenosine 3':5' monophosphate phosphodiesterase activity in preparations of neonatal rat cerebellum: modification by trifluoperazine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Animals, Newborn; Caffeine; Cerebellum; Drug Interactions; In Vitro Techniques; Kinetics; Rats; Theophylline; Trifluoperazine | 1981 |
Glucose and cyclic AMP as stimulators of somatostatin and insulin secretion from the isolated, perfused rat pancreas: a quantitative study.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Rats; Somatostatin; Theophylline | 1981 |
Delayed stimulatory effect of cyclic AMP on bone resorption in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Resorption; Bucladesine; Cells, Cultured; Mice; Parathyroid Hormone; Prostaglandins E; Theophylline | 1981 |
Effects of GnRH and drugs that affect cAMP levels on LH synthesis and release.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Castration; Cyclic AMP; Dose-Response Relationship, Drug; Female; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Theophylline | 1981 |
The role of adenosine 3',5'-monophosphate in dopaminergic inhibition of prolactin release in anterior pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bromocriptine; Calcium; Cells, Cultured; Cholera Toxin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Kinetics; Male; Pituitary Gland, Anterior; Prolactin; Rats; Theophylline | 1981 |
Monolayer formation in cultured pancreatic islets by 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cell Adhesion; Cells, Cultured; Insulin; Islets of Langerhans; Rats; Theophylline | 1981 |
Insulin release. Demonstration of a priming effect of 3-isobutyl-1-methyl-xanthine (IBMX) on islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Rats; Rats, Inbred Strains; Theophylline | 1981 |
Neurotransmitter- and neuromodulator-dependent alterations in phosphorylation of protein I in slices of rat facial nucleus.
Topics: 1-Methyl-3-isobutylxanthine; 5,7-Dihydroxytryptamine; Animals; Brain Stem; Calcium; Facial Nerve; In Vitro Techniques; Kinetics; Male; Nerve Tissue Proteins; Phosphorylation; Potassium; Rats; Serotonin; Synapsins; Theophylline | 1981 |
Mechanisms of action of cyclic nucleotides on a bursting pacemaker and silent neuron in Aplysia.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Calcium; Cyclic AMP; Electric Stimulation; Gallopamil; Neurons; Potassium; Sodium; Theophylline | 1981 |
A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cats; Depression, Chemical; Dose-Response Relationship, Drug; Myocardial Contraction; Papaverine; Phosphodiesterase Inhibitors; Theophylline | 1981 |
Evidence against a role of cyclic nucleotides in the regulation of anaphylactic histamine release in isolated rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aza Compounds; Cyclic AMP; Cyclic GMP; Histamine Release; Male; Mast Cells; Purinones; Rats; Rats, Inbred Strains; Theophylline | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Mice; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate; Theophylline; Time Factors | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1981 |
Effects of dopamine on prolactin secretion and cyclic AMP accumulation in the rat anterior pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cholera Toxin; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Pituitary Gland, Anterior; Prolactin; Rats; Theophylline | 1981 |
Efflux in isolated hepatocytes as a possible correlate of secretion in vivo: induced exit of the folic acid analog methotrexate, by dibutyryl cyclic AMP or isobutyl methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Bucladesine; In Vitro Techniques; Kinetics; Liver; Male; Methotrexate; Rats; Theophylline | 1981 |
Does cyclic 3' ,5'-adenosine monophosphate act as second messenger in a voltage-dependent response to 5-hydroxytryptamine in Aplysia?
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenylyl Cyclase Inhibitors; Animals; Aplysia; Cyclic AMP; Dithionitrobenzoic Acid; Dose-Response Relationship, Drug; Imidazoles; Membrane Potentials; Neostigmine; Neurons; Serotonin; Theophylline; Tubocurarine | 1981 |
Rod photoresponses in the absence of external sodium in retinae treated with phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Bufo bufo; Calcium; Ion Channels; Magnesium; Manganese; Membrane Potentials; Photoreceptor Cells; Retina; Sodium; Theophylline | 1981 |
Adenosine 3',5'-phosphate phosphodiesterase and pheromone response in the yeast Saccharomyces cerevisiae.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Caffeine; Cyclic AMP; Interphase; Mating Factor; Peptides; Saccharomyces cerevisiae; Theophylline; Xanthines | 1981 |
Induction by cholera toxin of synchronous divisions in vivo in the epidermis resulting in hyperplasia.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bucladesine; Cell Division; Cholera Toxin; Cyclic AMP; Isoproterenol; Kinetics; Mice; Prostaglandins E; Rats; Skin; Skin Physiological Phenomena; Theophylline | 1981 |
Facilitation of progesterone induced lordosis behavior by phosphodiesterase inhibitors in estrogen primed rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Drug Synergism; Estradiol; Estrogens; Estrus; Female; Phosphodiesterase Inhibitors; Pregnancy; Progesterone; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Theophylline | 1981 |
A tentative explanation of the stimulatory effect of methylxanthines (pentoxifylline and isobutylmethylxanthine) on the secretory process in rat extraorbital lacrimal gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carbachol; Dose-Response Relationship, Drug; Lacrimal Apparatus; Male; Norepinephrine; Pentoxifylline; Proteins; Rats; Rats, Inbred Strains; Sympathomimetics; Theobromine; Theophylline; Xanthines | 1981 |
Effect of 3-isobutyl-1-methylxanthine on HCO3- transport in turtle bladder. Evidence for electrogenic HCO3- secretion.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Kinetics; Ouabain; Sodium; Theophylline; Turtles; Urinary Bladder | 1982 |
Increased levels of 3',5'-cyclic adenosine monophosphate induced by cobaltous ion or 3-isobutylmethylxanthine in the incubated mouse retina: evidence concerning location and response to ions and light.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid; Calcium; Cobalt; Cyclic AMP; Darkness; Egtazic Acid; Kinetics; Light; Mice; Mice, Inbred C57BL; Ouabain; Photoreceptor Cells; Retina; Theophylline | 1982 |
Calcium and pancreatic beta-cell function: modification of 45Ca fluxes by methylxanthines and dibutyryl cyclic-AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; In Vitro Techniques; Islets of Langerhans; Mice; Theophylline; Xanthines | 1981 |
cAMP and calcium in generation of slow waves in cat colon.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Caffeine; Calcium; Cats; Colon; Cyclic AMP; Dibutyryl Cyclic GMP; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth; Theophylline; Time Factors | 1982 |
Comparison of the effects of 3-isobutyl-1-methylxanthine and adenosine cyclic 3':5'-monophosphate on the induction of skin tumors by the initiation-promotion protocol and by the complete carcinogenesis process.
Topics: 1-Methyl-3-isobutylxanthine; 9,10-Dimethyl-1,2-benzanthracene; Animals; Cyclic AMP; DNA; Female; In Vitro Techniques; Mice; Mice, Inbred Strains; Polyamines; Protein Biosynthesis; RNA; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1982 |
Pharmacological evidence that LH-RH action on lordosis behavior is mediated through a rise in cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Female; Gonadotropin-Releasing Hormone; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Theophylline | 1982 |
Stimulation of alpha-amylase release and cyclic AMP accumulation by catecholamine in rat parotid slices in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Albuterol; alpha-Amylases; Amylases; Animals; Catecholamines; Cyclic AMP; In Vitro Techniques; Male; Metaproterenol; Norepinephrine; Parotid Gland; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Effect of 3-isobutyl-1-methylxanthine on prolactin actions on RNA synthesis, casein synthesis, lipid synthesis and ornithine decarboxylase activity in mouse mammary gland explants.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carboxy-Lyases; Caseins; Dose-Response Relationship, Drug; Female; Lipids; Mammary Glands, Animal; Mice; Ornithine Decarboxylase; Pregnancy; Prolactin; RNA; Theophylline | 1982 |
Effect of methylxanthines on the spontaneous appetite for NaCl solutions in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Appetite; Female; Rats; Rats, Inbred Strains; Sodium Chloride; Theophylline | 1982 |
Effects of inhibitors of cyclic nucleotide phosphodiesterase on the actions of vasoactive intestinal peptide and secretin on pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Guinea Pigs; Male; Pancreas; Secretin; Theophylline; Vasoactive Intestinal Peptide | 1982 |
Effects of methylisobutylxanthine (MIX) on the secretion of pancreatic juice in the blood-perfused canine pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Cyclic AMP; Dogs; In Vitro Techniques; Pancreas; Pancreatic Juice; Perfusion; Theophylline | 1982 |
Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity of rat hepatoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cyclic AMP; Dexamethasone; Drug Therapy, Combination; Liver Neoplasms; Liver Neoplasms, Experimental; Plasminogen Activators; Rats; Theophylline | 1982 |
The action of phosphodiesterase inhibitors on the hypersensitivity of frog photoreceptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium; In Vitro Techniques; Light; Papaverine; Phosphodiesterase Inhibitors; Photoreceptor Cells; Rana catesbeiana; Theophylline | 1982 |
Direct effects of sex steroids on prolactin release at the anterior pituitary level: interactions with dopamine, thyrotropin-releasing hormone, and isobutylmethylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Dihydrotestosterone; Dopamine; Drug Interactions; Estradiol; Female; Gonadal Steroid Hormones; Pituitary Gland, Anterior; Prolactin; Promegestone; Rats; Theophylline; Thyrotropin-Releasing Hormone | 1982 |
Paradoxical stimulation by 1-methyl-3-isobutylxanthine of rat liver cyclic AMP phosphodiesterase activity.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Liver; Rats; Theophylline | 1982 |
Blockade by haloperidol of the increase in tryptophan hydroxylase activity induced by incubation of slices of brain stem with dibutyryl cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Stem; Bucladesine; Caffeine; Calcium; Haloperidol; Male; Rats; Theophylline; Tryptophan Hydroxylase | 1982 |
Stimulation of palatal glycosaminoglycan synthesis by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; Dinoprostone; Embryo, Mammalian; Epoprostenol; Female; Glycosaminoglycans; Male; Mice; Mice, Inbred C57BL; Palate; Pregnancy; Prostaglandins E; Theophylline | 1982 |
The stimulatory action of phosphodiesterase inhibitors on the flexor reflex of the hind limb in the spinal rat.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Drug Interactions; Male; Phenoxybenzamine; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Reflex; Rolipram; Spinal Cord; Theophylline | 1982 |
Effect of 3-isobutyl-1-methylxanthine on histamine-stimulated gastric secretion in dogs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Dogs; Gastric Acid; Gastric Juice; Histamine; Theophylline; Time Factors | 1982 |
Opposite effects of a beta-adrenergic agonist and a phosphodiesterase inhibitor on glucose transport in isolated human adipocytes: isoproterenol increases Vmax and IBMX increases Ks.
Topics: 1-Methyl-3-isobutylxanthine; 3-O-Methylglucose; Adipose Tissue; Biological Transport, Active; Female; Humans; In Vitro Techniques; Isoproterenol; Kinetics; Lipolysis; Male; Methylglucosides; Methylglycosides; Propranolol; Theophylline | 1982 |
Divergent effects of methylxanthines and adenylate cyclase agonists on monocyte cytotoxicity and cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alprostadil; Antibody-Dependent Cell Cytotoxicity; Cyclic AMP; Humans; In Vitro Techniques; Isoproterenol; Monocytes; Prostaglandins E; Theophylline; Xanthines | 1982 |
Time parameters of contraction of inotropically responding cultured heart cells in relation to cellular cyclic AMP levels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Bucladesine; Calcium Chloride; Cardiotonic Agents; Cells, Cultured; Cyclic AMP; Epinephrine; Isoproterenol; Myocardial Contraction; Myocardium; Ouabain; Phenylephrine; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Effect of purine derivatives, papaverine hydrochloride, and imidazole on enterotoxin formation by Clostridium perfringens type A.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Clostridium perfringens; Enterotoxins; Imidazoles; Mercaptopurine; Papaverine; Spores, Bacterial; Theophylline | 1982 |
Clonidine prevents methylxanthine stimulation of norepinephrine metabolism in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Brain; Cerebellum; Clonidine; Diazepam; Hippocampus; Kinetics; Male; Naloxone; Norepinephrine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Clonidine suppresses methylxanthine induced quasi-morphine withdrawal syndrome.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Clonidine; Humans; Male; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Theophylline | 1982 |
The alterative effect of isobutylmethylxanthine in hypofunctional human neutrophil chemotaxis.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Chemotaxis, Leukocyte; Child; Female; Humans; Male; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Periodontitis; Theophylline | 1982 |
Methylxanthine activation of noradrenergic unit activity and reversal by clonidine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clonidine; Electrophysiology; Locus Coeruleus; Male; Nalorphine; Neurons; Norepinephrine; Rats; Sympathetic Nervous System; Theophylline | 1982 |
Regulation of cAMP-dependent protein kinase subunit levels in Friend erythroleukemic cells. Effects of differentiation and treatment with 8-Br-cAMP and methylisobutyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Differentiation; Chromatography, DEAE-Cellulose; Cyclic AMP; Isoelectric Focusing; Leukemia, Experimental; Macromolecular Substances; Protamine Kinase; Protein Kinases; Theophylline | 1983 |
Growth-dependent AIB and meAIB uptake in LLC-PK1 cells: effects of differentiation inducers and of TPA.
Topics: 1-Methyl-3-isobutylxanthine; Acetamides; Aminoisobutyric Acids; Animals; Biological Transport, Active; Cell Division; Cell Line; Kidney; Membrane Potentials; Ouabain; Phorbols; Protein Biosynthesis; RNA; Sodium; Swine; Tetradecanoylphorbol Acetate; Theophylline | 1983 |
FMRFamide inhibition of a molluscan heart is accompanied by increases in cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; FMRFamide; Heart; Mollusca; Oligopeptides; Theophylline | 1982 |
Development and initiation of sperm motility in the hamster epididymis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cricetinae; Cyclic AMP; Epididymis; Kinetics; Male; Semen; Sperm Motility; Spermatozoa; Theophylline | 1980 |
The effect of isobutylmethylxanthine on the photoresponse and phosphorylation of phosphatidylinositol in octopus retina.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Darkness; Kinetics; Light; Octopodiformes; Phosphatidylinositols; Phosphorylation; Photic Stimulation; Photoreceptor Cells; Retina; Theophylline | 1983 |
Effects of cyclic AMP on DNA replication and protein biosynthesis in fetal rat islets of Langerhans maintained in tissue culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; Cyclic AMP; DNA Replication; Fetus; Islets of Langerhans; Proinsulin; Protein Biosynthesis; Rats; Theophylline; Transcription, Genetic | 1982 |
The lack of correlation between inhibition of aggregation and cAMP levels with canine platelets.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alprostadil; Animals; Arachidonic Acids; Cyclic AMP; Depression, Chemical; Dogs; Epinephrine; Female; Male; Papaverine; Phosphodiesterase Inhibitors; Platelet Aggregation; Prostaglandins E; Theophylline | 1982 |
Differential mitogenic effects of methyl isobutyl xanthine and a tumor growth factor on G1-arrested 3T3 T proadipocytes at the predifferentiation GD state and the growth-factor deficiency GS state.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adipose Tissue; Animals; Cell Count; Cell Differentiation; Cell Line; Epidermal Growth Factor; Growth Substances; Interphase; Mice; Mitogens; Structure-Activity Relationship; Theophylline | 1983 |
Prostacyclin biosynthesis in vascular endothelium is not inhibited by cyclic AMP. Studies with 3-isobutyl-1-methylxanthine and forskolin.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Epoprostenol; Humans; Isoproterenol; Prostaglandin Antagonists; Prostaglandins; Stimulation, Chemical; Theophylline; Umbilical Veins | 1982 |
Effect of thyrotropin releasing hormone on the accumulation of cAMP by parietal ganglia of a gastropod.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brain; Cyclic AMP; Ganglia; Lymnaea; Theophylline; Thyrotropin-Releasing Hormone | 1983 |
Studies on the roles of cyclic AMP and calcium in the development of bovine sperm motility.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bicarbonates; Calcium; Cattle; Cyclic AMP; Epididymis; Male; Sperm Maturation; Sperm Motility; Spermatozoa; Theophylline | 1983 |
beta-Adrenergic stimulation of the adenosine 3',5'-monophosphate system regulated by cholinergic stimuli in the prostate.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atropine; Calcimycin; Calcium; Cell Membrane; Cyclic AMP; Hexamethonium; Hexamethonium Compounds; Isoproterenol; Male; Parasympathetic Nervous System; Prostate; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tetracaine; Theophylline; Verapamil | 1983 |
Modulation of lipoprotein lipase activity in cultured rat mesenchymal heart cells and preadipocytes by dibutyryl cyclic AMP, cholera toxin and 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Bucladesine; Cells, Cultured; Cholera Toxin; Cyclic AMP; Intracellular Membranes; Lipoprotein Lipase; Male; Myocardium; Rats; Theophylline | 1983 |
Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fasting; Glucagon; Glyburide; Insulin; Insulin Secretion; Male; Pancreas; Pancreatic Hormones; Rats; Rats, Inbred Strains; Somatostatin; Theophylline | 1983 |
Cyclic GMP efflux from liver slices.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Cyclic GMP; In Vitro Techniques; Iodoacetamide; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Probenecid; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line; Cell Survival; Cyclic AMP; Female; Humans; Radiation-Protective Agents; Theophylline | 1983 |
Action of histamine and 3-isobutyl-1-methylxanthine on cAMP activation of protein kinase in dog gastric mucosa.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Dogs; Enzyme Activation; Gastric Mucosa; Histamine; In Vitro Techniques; Protein Kinases; Proteins; Theophylline | 1983 |
Regulation of abalone sperm cyclic AMP concentrations and the acrosome reaction by calcium and methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Calcium; Cyclic GMP; Male; Mollusca; Sea Urchins; Spermatozoa; Theophylline; Xanthines | 1983 |
Calcium requirement for the inhibition by theophylline of histamine release from mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Barium; Calcium; Cyclic AMP; Histamine; Male; Mast Cells; Rats; Rats, Inbred Strains; Strontium; Theophylline | 1983 |
Pemphigus antibodies fixation and keratinocyte differentiation in organ cultures. Effects of some agents influencing the intracellular content of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibody Affinity; Cell Differentiation; Cyclic AMP; Epidermal Cells; Epinephrine; Esophagus; Humans; Organ Culture Techniques; Pemphigus; Propranolol; Rabbits; Theophylline | 1982 |
Facilitation of cAMP increments during ADCC mediated by monocytes pretreated with cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Alprostadil; Antibody-Dependent Cell Cytotoxicity; Cyclic AMP; Erythrocytes; Glucuronidase; Humans; Immunoglobulin G; Isoproterenol; Monocytes; Muramidase; Phosphodiesterase Inhibitors; Prostaglandins E; Theophylline | 1983 |
Hormonal activation of type-L hormone-sensitive lipase measured in defatted heart powders.
Topics: 1-Methyl-3-isobutylxanthine; Acetone; Animals; Bucladesine; Enzyme Activation; Epinephrine; Ether; Heart; In Vitro Techniques; Lipoprotein Lipase; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Cyclic AMP; Cytotoxicity, Immunologic; Interleukin-2; Kinetics; Lymphocytes; Mice; Mice, Inbred BALB C; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate; Theophylline; Thymus Gland | 1983 |
Noradrenergic modulation of serotonin synthesis and metabolism. II. Stimulation by 3-isobutyl-1-methylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Serotonin; Theophylline; Tryptophan | 1983 |
The effect of prostaglandin I2 and 6a-Carba-PGI2 on the motility of isolated osteoclasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cell Movement; Cycloheximide; Epoprostenol; Hypoxanthine; Hypoxanthines; Imidazoles; Kinetics; Osteoclasts; Prostaglandins; Rats; Theophylline | 1983 |
Methylxanthines stimulate calcium transport and inhibit cyclic nucleotide phosphodiesterases in abalone sperm.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Biological Transport; Calcium; Cyclic AMP; Male; Mollusca; Phosphodiesterase Inhibitors; Spermatozoa; Theophylline; Verapamil | 1983 |
Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Axons; Brain; Clonidine; Diazepam; Dihydroxyphenylalanine; Hydroxylation; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Stimulation, Chemical; Theophylline; Tyrosine 3-Monooxygenase; Yohimbine | 1983 |
Endogenous adenosine inhibits excitatory transmission in the rat olfactory cortex slice.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Aspartic Acid; Central Nervous System; Cerebral Cortex; Cyclic AMP; Electric Stimulation; Male; Olfactory Pathways; Potassium; Rats; Synaptic Transmission; Theophylline | 1983 |
In vitro regulation of human monocyte insulin receptors by insulin and 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Cyclic AMP; Glucagon; Humans; Insulin; Kinetics; Monocytes; Receptor, Insulin; Receptors, Cell Surface; Receptors, Glucagon; Theophylline | 1983 |
Effects of inhibitors of cyclic nucleotide phosphodiesterase on actions of cholecystokinin, bombesin, and carbachol on pancreatic acini.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amylases; Animals; Bombesin; Carbachol; Cyclic AMP; Guinea Pigs; Imidazoles; In Vitro Techniques; Pancreas; Peptides; Sincalide; Theophylline | 1983 |
Action of 3-isobutyl-1-methylxanthine and prostaglandins D2 and E1 on histamine release from rat and guinea pig mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Ascitic Fluid; Female; Guinea Pigs; Histamine Release; Lung; Male; Mast Cells; Ovalbumin; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Rats; Rats, Inbred Strains; Theophylline | 1983 |
The regulation of glucose transport by cAMP stimulators via three different mechanisms in rat and human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3-O-Methylglucose; Adipose Tissue; Animals; Bucladesine; Carrier Proteins; Cell Membrane; Colforsin; Cyclic AMP; Diterpenes; Glucose; Humans; Insulin; Isoproterenol; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cattle; Dipyridamole; Hydrolysis; Kinetics; Liver; Papaverine; Quinolines; Quinolones; Theophylline | 1983 |
Agents that activate cyclic AMP-dependent protein kinase inhibit explant culture growth and mitotic activity.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Cell Division; Culture Techniques; Cyclic AMP; Dinoprost; Dinoprostone; Enzyme Activation; Epinephrine; Histamine; Mitosis; Prostaglandins E; Prostaglandins F; Protein Kinases; Skin; Swine; Theophylline | 1983 |
The effect of phosphodiesterase inhibitors on the electrical activity of toad rods.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bufo bufo; Kinetics; Membrane Potentials; Phosphodiesterase Inhibitors; Photic Stimulation; Photoreceptor Cells; Theophylline; Time Factors | 1983 |
Comparison of 3-isobutyl-1-methylxanthine-induced accumulation of putrescine in rat pancreas and liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Liver; Male; Ornithine Decarboxylase; Pancreas; Putrescine; Rats; Rats, Inbred Strains; Theophylline | 1983 |
Inhibition of prostacyclin synthesis in endothelial cells by methylisobutylxanthine is not mediated through elevated cAMP level.
Topics: 1-Methyl-3-isobutylxanthine; 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Bucladesine; Cyclic AMP; Endothelium; Epoprostenol; Female; Humans; Kinetics; Muscle, Smooth, Vascular; Pregnancy; Swine; Theophylline; Umbilical Veins | 1983 |
Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Colforsin; Cyclic AMP; Diterpenes; Female; Follicle Stimulating Hormone; Mice; Mice, Inbred Strains; Oocytes; Ovarian Follicle; Swine; Theophylline | 1984 |
Glucose stimulation of beta-cell DNA replication in the intact rat and in pancreatic islets in suspension culture. Effects of alpha-ketoisocaproic acid, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine in the in vitro system.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cells, Cultured; DNA Replication; Glucose; Islets of Langerhans; Keto Acids; Male; Rats; Rats, Inbred Strains; Theophylline; Thymidine | 1983 |
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Phentolamine; Propranolol; Quinidine; Receptors, Cell Surface; Receptors, Purinergic; Tetrodotoxin; Theophylline | 1983 |
Cyclic nucleotide responses and radiation-induced mitotic delay in Physarum polycephalum.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Caffeine; Cobalt Radioisotopes; Cyclic AMP; Cyclic GMP; Gamma Rays; Mitosis; Phosphodiesterase Inhibitors; Physarum; Theophylline; Time Factors | 1984 |
[Inhibition of cyclic nucleotide phosphodiesterase from the rod outer segments of the frog retina by 3-hydroxypyridine].
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Antioxidants; In Vitro Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Photoreceptor Cells; Pyridines; Rana ridibunda; Rod Cell Outer Segment; Theophylline; Time Factors | 1984 |
[Decrease in the lipid content of human atherosclerotic aorta cells as affected by compounds increasing the intracellular level of cyclic AMP].
Topics: 1-Methyl-3-isobutylxanthine; Aortic Diseases; Arteriosclerosis; Cholera Toxin; Cholesterol; Cholesterol Esters; Cyclic AMP; Humans; In Vitro Techniques; Lipid Metabolism; Phospholipids; Theophylline; Triglycerides | 1984 |
Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Animals; Glucose; Glycogen; Glycolysis; Insulin; Lactates; Lactic Acid; Muscles; Phenylisopropyladenosine; Rats; Theophylline | 1984 |
The effects of 1-methyl-3-isobutylxanthine on insulin-sensitive 2-deoxyglucose transport.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Adipose Tissue; Animals; Biological Transport, Active; Deoxy Sugars; Deoxyglucose; Insulin; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Effects of 3-isobutyl-1-methylxanthine on secretory response, cAMP accumulation and DNA synthesis of islets from postnatal and adult Wistar rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; DNA; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Pregnancy; Rats; Rats, Inbred Strains; Theophylline | 1982 |
Cyclic adenosine 3',5'-monophosphate modulation of mullerian duct regression.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Mullerian Hormone; Bucladesine; Cattle; Cyclic AMP; Dibutyryl Cyclic GMP; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Testicular Hormones; Theophylline; Time Factors | 1984 |
Effects of dibutyryl adenosine 3':5'-cyclic monophosphate and other agents on induction of alkaline phosphatase activity in monkey kidney cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Animals; Bromodeoxyuridine; Bucladesine; Butyrates; Butyric Acid; Cell Line; Dexamethasone; Enzyme Induction; Kidney; Macaca fascicularis; Theophylline; Time Factors | 1984 |
Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Aminophylline; Animals; Biological Transport, Active; Caffeine; Calcium; Hydrogen-Ion Concentration; Kinetics; Male; Mollusca; Potassium Cyanide; Spermatozoa; Theobromine; Theophylline; Xanthines | 1984 |
[Inhibition of platelet aggregation and cyclic nucleotide phosphodiesterase (specifically cyclAMP) by 3-hydroxypyridine derivatives].
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Aspirin; Humans; Platelet Aggregation; Pyridines; Pyridoxal; Pyridoxal Phosphate; Theophylline | 1984 |
Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Biological Transport, Active; Caffeine; Cell Line; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Papaverine; Phenylisopropyladenosine; Rats; Theophylline; Uridine; Xanthines | 1984 |
Interactions of a phosphodiesterase inhibitor, 3-isobutyl-1-methyl xanthine, with prostaglandin E2, follicle-stimulating hormone, luteinizing hormone, and dibutyryl cyclic 3',5'-adenosine monophosphate (cAMP) in cAMP and steroid production by neonatal rat
Topics: 1-Methyl-3-isobutylxanthine; Androstenedione; Animals; Animals, Newborn; Bucladesine; Cyclic AMP; Dinoprostone; Estradiol; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Kinetics; Luteinizing Hormone; Ovary; Prostaglandins E; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Relationship between cycles in level of serotonin N-acetyltransferase activity and cyclic GMP content of cultured chick pineal glands.
Topics: 1-Methyl-3-isobutylxanthine; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Calcium Chloride; Chickens; Circadian Rhythm; Cyclic GMP; Darkness; Egtazic Acid; Etazolate; Folic Acid; Hypoxanthine; Hypoxanthines; Light; Pineal Gland; Theophylline | 1984 |
Comparative effects of RX 781094, mianserin, yohimbine, rauwolscine and prazosin in reversing clonidine inhibition of MIX-stimulated lipolysis in hamster isolated white fat cells.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Clonidine; Cricetinae; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Lipolysis; Male; Mianserin; Prazosin; Theophylline; Yohimbine | 1984 |
Gastric mucosa permeability and HCO3- secretion 'in vivo' during perfusion of damaging and protective agents across canine Heidenhain pouches.
Topics: 1-Methyl-3-isobutylxanthine; Acetazolamide; Animals; Bicarbonates; Butyrates; Butyric Acid; Cimetidine; Dogs; Gastric Mucosa; Hydrogen-Ion Concentration; Perfusion; Permeability; Stomach; Theophylline | 1984 |
Effects of theophylline and dibutyryl cyclic adenosine monophosphate on the membrane potential of mouse pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Animals; Bucladesine; Calcium; Female; Gallopamil; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Membrane Potentials; Mice; Theophylline; Time Factors | 1984 |
Behavioral interaction of adenosine and methylxanthines on central purinergic systems.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Caffeine; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity; Papaverine; Theophylline | 1984 |
Forskolin and phosphodiesterase inhibitors stimulate rat granulosa cell differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 20-alpha-Dihydroprogesterone; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Estrogens; Female; Follicle Stimulating Hormone; Granulosa Cells; Progesterone; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, LH; Theophylline | 1984 |
Adenosine and adenosine analogues stimulate adenosine cyclic 3', 5'-monophosphate-dependent chloride secretion in the mammalian ileum.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport; Chlorides; Cyclic AMP; Cyclic GMP; Ileum; Kinetics; Male; Phenylisopropyladenosine; Rabbits; Theophylline | 1984 |
Effects of dibutyryl cyclic AMP, theophylline or isobutylmethylxanthine on human renal cancer cell line (OUR-10) and normal human kidney cell.
Topics: 1-Methyl-3-isobutylxanthine; Bucladesine; Cell Differentiation; Cell Line; Humans; Kidney; Kidney Neoplasms; Theophylline | 1984 |
Caffeine and related methylxanthines: possible naturally occurring pesticides.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Chlorphenamidine; Cyclic AMP; Feeding Behavior; Insecta; Insecticides; Larva; Lepidoptera; Moths; Papaverine; Pesticide Synergists; Theophylline; Xanthines | 1984 |
Inhibition of guanylate cyclases by methylxanthines and papaverine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Guanylate Cyclase; Kinetics; Liver; Lung; Male; Organ Specificity; Papaverine; Rats; Rats, Inbred Strains; Theophylline | 1984 |
The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility.
Topics: 1-Methyl-3-isobutylxanthine; Adolescent; Adult; Caffeine; Humans; In Vitro Techniques; Male; Sperm Motility; Theophylline; Xanthines | 1984 |
Differential effects of two phosphodiesterase inhibitors on fat cell metabolism.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Cholera Toxin; Cyclic AMP; Imidazoles; In Vitro Techniques; Insulin; Kinetics; Lipolysis; Male; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Stimulation by octopamine of the sodium efflux in barnacle muscle fibres.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Chlorphenamidine; In Vitro Techniques; Kinetics; Muscles; Octopamine; Ouabain; Sodium; Theophylline; Thoracica | 1984 |
Cyclic nucleotide phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, induces cytodifferentiation of follicular granulosa cells cultured in serum-free medium.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cell Differentiation; Culture Media; Cyclic AMP; Estrogens; Female; Granulosa Cells; Luteinizing Hormone; Microscopy, Electron, Scanning; Ovarian Follicle; Progestins; Rats; Rats, Inbred Strains; Steroids; Theophylline | 1984 |
Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Cattle; Cells, Cultured; Cholesterol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Fibroblasts; Humans; Kinetics; Mevalonic Acid; Skin; Sterols; Tetranitromethane; Theophylline; Thionucleotides | 1993 |
Isbufylline, a xanthine derivative, inhibits bronchoconstrictor responses produced by stimulation of capsaicin-sensitive sensory nerves in guinea-pig: 'In vitro' and 'in vivo' evidence.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Capsaicin; Carbachol; Choline; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Neurokinin A; Neurons, Afferent; Stimulation, Chemical; Theophylline; Trachea; Vagus Nerve | 1993 |
Caffeine-induced calcium oscillations in heavy-sarcoplasmic-reticulum vesicles from rabbit skeletal muscle.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Hydrogen-Ion Concentration; Magnesium Chloride; Muscle Proteins; Muscles; Neomycin; Osmolar Concentration; Osmotic Pressure; Rabbits; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Temperature; Theophylline | 1994 |
Phosphatase inhibitors activate normal and defective CFTR chloride channels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Chloride Channels; CHO Cells; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; In Vitro Techniques; Membrane Proteins; Mutation; Phosphoric Monoester Hydrolases; Phosphorylation; Recombinant Proteins; Theophylline; Vanadates | 1994 |
Contribution of known mitogenic signaling pathways to induction of DNA synthesis in quiescent Chinese hamster fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cholera Toxin; Cricetinae; Cricetulus; Cyclic AMP; Epidermal Growth Factor; Fibroblasts; Insulin; Mitosis; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Ribosomal Protein S6; Ribosomal Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Theophylline | 1994 |
Forskolin and methylxanthines block the increase in intracellular pH during meiosis in Xenopus laevis oocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Female; Hydrogen-Ion Concentration; Meiosis; Oocytes; Progesterone; Sodium-Hydrogen Exchangers; Theophylline; Xenopus laevis | 1994 |
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline | 1995 |
IBMX induces calcium release from intracellular stores in rat sensory neurones.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Biological Transport; Bucladesine; Caffeine; Calcium; Cell Compartmentation; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Endoplasmic Reticulum; Ganglia, Spinal; Neurons, Afferent; Rats; Theophylline | 1995 |
Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cattle; Dogs; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Purinergic Antagonists; Pyrrolidinones; Rats; Receptors, Purinergic; Rolipram; Theophylline; Xanthines | 1993 |
Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaline Phosphatase; Base Sequence; Chloride Channels; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Single-Stranded; Humans; Ion Channels; Membrane Potentials; Membrane Proteins; Molecular Sequence Data; Pancreas; Theophylline; Tumor Cells, Cultured | 1993 |
Mechanisms of antagonistic action of internal Ca2+ on serotonin-induced potentiation of Ca2+ currents in Helix neurones.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Calmodulin; Chlorpromazine; Cyclic AMP; Egtazic Acid; Electric Conductivity; Enzyme Activation; Ethers, Cyclic; Helix, Snails; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoric Diester Hydrolases; Serotonin; Theophylline; Trifluoperazine | 1993 |
Adenosine inhibits efferent function of extrinsic capsaicin-sensitive sensory nerves in the enteric nervous system.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Adenosine; Animals; Capsaicin; Electric Stimulation; Electrophysiology; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mesentery; Muscle Contraction; Myenteric Plexus; Nerve Fibers; Neurons, Afferent; Neurons, Efferent; Substance P; Theophylline | 1993 |
Leu-enkephalin modulates the migration inhibition of mouse splenocytes induced by cAMP-elevating agents.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Migration Inhibition; Cell Movement; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; In Vitro Techniques; Mice; Mice, Inbred CBA; Naloxone; Spleen; Theophylline | 1993 |
Multiple effects of caffeine on calcium current in rat ventricular myocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Calcium Channels; Egtazic Acid; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Theophylline | 1993 |
Muscarinic agonists have no measurable effect on cGMP formation of rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Bethanechol; Bethanechol Compounds; Calcium; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Kinetics; Male; Nitroprusside; Norepinephrine; Parasympathomimetics; Pineal Gland; Rats; Rats, Sprague-Dawley; Theophylline | 1993 |
Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Male; Purinergic P1 Receptor Antagonists; Quinazolines; Saimiri; Theophylline; Triazoles; Xanthines | 1996 |
Mitoxantrone induces nonimmunological histamine release from rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antineoplastic Agents; Calcium; Carcinogens; Cell Division; Cyclic AMP; Drug Interactions; Enzyme Inhibitors; Ethers, Cyclic; Exocytosis; Histamine Release; Mast Cells; Mitoxantrone; Okadaic Acid; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Phosphodiesterase Inhibitors; Pleura; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Theophylline; Trifluoperazine | 1996 |
Extensive alteration of fungal gene transcript accumulation and elevation of G-protein-regulated cAMP levels by a virulence-attenuating hypovirus.
Topics: 1-Methyl-3-isobutylxanthine; Caffeine; Cyclic AMP; Fungal Proteins; Genes, Fungal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Polymerase Chain Reaction; RNA Viruses; RNA, Fungal; RNA, Messenger; Signal Transduction; Theophylline; Transcription, Genetic; Virulence; Virus Replication; Xylariales | 1996 |
Effects of selective and non-selective phosphodiesterase inhibitors on tracheal mucus secretion in the rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; In Vitro Techniques; Isoenzymes; Male; Mucus; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Theophylline; Trachea; Xanthines | 1996 |
Activation of the Na(+)-K+ pump in frog erythrocytes by catecholamines and phosphodiesterase blockers.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Antagonists; Animals; Biological Transport, Active; Enzyme Activation; Erythrocytes; In Vitro Techniques; Isoproterenol; Kinetics; Norepinephrine; Ouabain; Phentolamine; Phosphodiesterase Inhibitors; Potassium; Propranolol; Rana temporaria; Sodium; Sodium-Potassium-Exchanging ATPase; Theophylline | 1996 |
Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function.
Topics: 1-Methyl-3-isobutylxanthine; Basophils; Dose-Response Relationship, Drug; Humans; Lung; Mast Cells; Phosphodiesterase Inhibitors; Theophylline | 1997 |
Effect of papaverine on synaptic transmission in the guinea-pig ileum.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium Channels; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Ileum; Male; Papaverine; Phosphoric Diester Hydrolases; Synaptic Transmission; Theophylline | 1997 |
Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats.
Topics: 1-Methyl-3-isobutylxanthine; Acoustic Stimulation; Animals; Caffeine; Convulsants; Dyphylline; Electroencephalography; Epilepsy; Female; Lipid Metabolism; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Theobromine; Theophylline; Xanthines | 1997 |
[Effects of beta-adrenergic agonists and phosphodiesterase inhibitors on the outflow facility of the eye].
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Albuterol; Animals; Aqueous Humor; Caffeine; Cattle; Cells, Cultured; Dobutamine; Epinephrine; Isoproterenol; Phosphodiesterase Inhibitors; Theophylline; Trabecular Meshwork | 1997 |
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.
Topics: 1-Methyl-3-isobutylxanthine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bucladesine; Cell Survival; Cyclic AMP; Dose-Response Relationship, Drug; fas Receptor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Humans; Interleukin-5; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Proto-Oncogene Proteins c-bcl-2; Pyrrolidinones; Rolipram; Theophylline | 1997 |
The xanthine derivatives and cerebral blood flow (CBF) after i.v. or i.c. administration in SHR rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carotid Body; Cerebrovascular Circulation; Hypolipidemic Agents; Injections; Injections, Intravenous; Male; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Pyridinolcarbamate; Rats; Rats, Inbred SHR; Theophylline; Xanthines | 1996 |
Suppression of drug-induced epileptiform discharges by cyclic AMP in rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 5'-Nucleotidase; Animals; Bethanechol; Cyclic AMP; Electrophysiology; Epilepsy; Extracellular Space; Hippocampus; Parasympathomimetics; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Theophylline | 1997 |
The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Animals; Colforsin; Cyclic AMP; Diterpenes; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine Monophosphate; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited beta-adrenergic mucin secretion response.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies; Chromatography, Gel; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Electrophoresis, Cellulose Acetate; Mucins; Phosphorylation; Precipitin Tests; Purinergic P1 Receptor Antagonists; Rats; Receptors, Adrenergic, beta; Submandibular Gland; Theobromine; Theophylline | 1998 |
Mediator-dependent effects of pentoxifylline on endothelium for transmigration of neutrophils.
Topics: 1-Methyl-3-isobutylxanthine; Adjuvants, Immunologic; Bucladesine; Cell Adhesion; Cell Movement; Endothelium, Vascular; Granulocyte Colony-Stimulating Factor; Humans; Interleukin-1; Interleukin-8; Lipopolysaccharides; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors; Theophylline; Tumor Necrosis Factor-alpha | 1999 |
Effects of phosphodiesterase inhibitors on cytokine production by microglia.
Topics: 1-Methyl-3-isobutylxanthine; Amrinone; Animals; Anti-Ulcer Agents; Cilostazol; Colforsin; Dipyridamole; DNA Primers; Gene Expression Regulation, Enzymologic; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Papaverine; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazines; Pyrrolidinones; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rolipram; Tetrazoles; Theophylline; Tumor Necrosis Factor-alpha; Vinca Alkaloids; Xanthines | 1999 |
Synergistic effects of neurotensin and beta-adrenergic agonist on 3,5-cyclic adenosine monophosphate accumulation and DNA synthesis in prostate cancer PC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Bucladesine; Cell Division; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoproterenol; Male; Neurotensin; Phosphodiesterase Inhibitors; Prostatic Neoplasms; Receptors, Adrenergic, beta; Receptors, Neurotensin; Theophylline; Tumor Cells, Cultured | 1999 |
Effects of A1-adenosine receptor antagonists on purinergic transmission in the guinea-pig vas deferens in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Neuroeffector Junction; Phentolamine; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Synaptic Transmission; Theophylline; Thioinosine; Vas Deferens; Xanthines; Yohimbine | 1999 |
The effect of papaverine on morphologic differentiation, proliferation and invasive potential of human prostatic cancer LNCaP cells.
Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Division; Cell Size; Cyclic AMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Male; Neoplasm Invasiveness; Papaverine; Phosphodiesterase Inhibitors; Prostatic Neoplasms; Radioimmunoassay; Theophylline; Tumor Cells, Cultured | 1999 |
Chronic effects of xanthines on levels of central receptors in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain Chemistry; Caffeine; Calcium Channels; Central Nervous System Stimulants; Cerebral Cortex; Corpus Striatum; Drug Interactions; Gene Expression Regulation; Male; Mice; Nerve Tissue Proteins; Pentoxifylline; Radioligand Assay; Receptors, Cholinergic; Receptors, Drug; Receptors, GABA; Receptors, Purinergic P1; Receptors, Serotonin; Theobromine; Theophylline; Xanthines | 1999 |
Keratinocyte-melanocyte co-cultures and pigmented reconstructed human epidermis: models to study modulation of melanogenesis.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Arbutin; Asian People; Benzofurans; Black People; Cells, Cultured; Coculture Techniques; Culture Media; Epidermal Cells; Ethnicity; Humans; Hydroquinones; Hydroxybenzoates; Indoles; Keratinocytes; Melanins; Melanocytes; Mice; Phenotype; Pyrones; Skin Pigmentation; Skin, Artificial; Theophylline; Thiophenes; Ultraviolet Rays; White People | 1999 |
Histamine H(2) receptor activated chloride conductance in myenteric neurons from guinea pig small intestine.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Animals; Calcium Channel Blockers; Chlorides; Cyclic AMP; Cyclooxygenase Inhibitors; Electric Conductivity; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guinea Pigs; Histamine; Intestine, Small; Membrane Potentials; Myenteric Plexus; Neurons; Niflumic Acid; omega-Conotoxins; Paracrine Communication; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Receptors, Histamine H2; Stress, Psychological; Theophylline; Thionucleotides | 2000 |
Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Caffeine; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Gene Expression; Humans; Magnesium; Membrane Potentials; Nitroprusside; Patch-Clamp Techniques; Potassium Channels; Recombinant Proteins; Theophylline; Transfection; Xanthines | 2000 |
Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Caffeine; Calcium Channel Blockers; Chlorides; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Iodides; Iodine Radioisotopes; Membrane Potentials; Membrane Proteins; ortho-Aminobenzoates; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphorylation; Respiratory Mucosa; Theophylline; Xanthines | 2000 |
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline | 2000 |
Antimitotic and cytotoxic effects of theophylline in MDA-MB-231 human breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Survival; DNA; DNA Replication; Dose-Response Relationship, Drug; Female; Humans; Mitosis; Phosphodiesterase Inhibitors; Theophylline; Time Factors; Tumor Cells, Cultured | 2000 |
Generation of reactive oxygen species by xanthine derivatives in MDA-MB-231 human breast cancer cells.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Female; Humans; Phosphodiesterase Inhibitors; Reactive Oxygen Species; Theophylline; Tumor Cells, Cultured | 2001 |
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; B-Lymphocytes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Spleen; Theophylline; Tumor Cells, Cultured; Up-Regulation; Xanthines | 2002 |
[The effect of cyclic nucleotides on the membrane potential of intact endothelium of isolated rabbit aorta].
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta; Bucladesine; Endothelium, Vascular; Membrane Potentials; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Rabbits; Theophylline | 2001 |
Relationship between bicarbonate and cyclic nucleotide in the promoting effects on head-to-head agglutination in boar spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cyclic AMP; Cyclic GMP; Male; Papaverine; Purinergic P1 Receptor Antagonists; Sodium Bicarbonate; Sperm Agglutination; Sperm Head; Swine; Theophylline | 2002 |
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Biological Transport; Caffeine; CHO Cells; Cricetinae; Deoxyglucose; Dimerization; Flavins; Glucose; Kinetics; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Recombinant Fusion Proteins; Theophylline; Transfection; Triazoles | 2002 |
Role of cyclic nucleotides in regulation of pulmonary artery tone in rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Dipyridamole; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pulmonary Artery; Rabbits; Signal Transduction; Sympathomimetics; Theophylline; Vasodilator Agents | 2003 |
Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Agonists; Adult; Albuterol; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Drug Combinations; Fenoterol; Humans; Leukotriene B4; Metaproterenol; Monocytes; Phosphodiesterase Inhibitors; Receptors, Adrenergic, beta-2; Theophylline | 2004 |
Estrogen regulation of in vitro brain tyrosine hydroxylase activity in the catfish Heteropneustes fossilis: interactions with cAMP-protein kinase A and protein kinase C systems in enzyme activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Catfishes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Estrogens; In Vitro Techniques; Kinetics; Phosphodiesterase Inhibitors; Protein Kinase C; Theophylline; Tyrosine 3-Monooxygenase | 2005 |
Cyclic AMP-protein kinase a and protein kinase C mediate in vitro T activation of brain tyrosine hydroxylase in the female catfish Heteropneustes fossilis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catfishes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Female; In Vitro Techniques; Isoquinolines; Kinetics; Naphthalenes; Phosphodiesterase Inhibitors; Prosencephalon; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Theophylline; Triiodothyronine; Tyrosine 3-Monooxygenase | 2005 |
TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acid Sequence; Animals; Calcium; Calmodulin; Coenzymes; Cyclic Nucleotide Phosphodiesterases, Type 1; DNA, Protozoan; Enzyme Activators; Enzyme Stability; Gene Dosage; Genetic Complementation Test; Guanosine Monophosphate; Magnesium; Molecular Sequence Data; Papaverine; Phosphodiesterase Inhibitors; Saccharomyces cerevisiae; Sequence Analysis, DNA; Substrate Specificity; Theophylline; Trypanosoma cruzi | 2007 |
Regulation of intestinal hPepT1 (SLC15A1) activity by phosphodiesterase inhibitors is via inhibition of NHE3 (SLC9A3).
Topics: 1-Methyl-3-isobutylxanthine; Amino Acid Transport Systems; Caco-2 Cells; Caffeine; Dipeptides; Humans; Hydrogen-Ion Concentration; Pentoxifylline; Peptide Transporter 1; Phosphodiesterase Inhibitors; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Symporters; Theophylline | 2007 |
PKA-dependent and independent cAMP signaling in 3T3-L1 fibroblasts differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Adipogenesis; Animals; Cell Differentiation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Fibroblasts; Insulin; Isoquinolines; Mice; Mitosis; Protein Kinase Inhibitors; Signal Transduction; Sulfonamides; Theophylline | 2009 |
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways.
Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline | 2012 |
Mechanisms contributing to the dopamine induction of crawl-like bursting in leech motoneurons.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; Dopamine; Leeches; Locomotion; Motor Neurons; Phosphodiesterase Inhibitors; Swimming; Theophylline | 2012 |
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-Associated Death Protein; Cell Line, Tumor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinase Type I; Cyclic AMP-Dependent Protein Kinase Type II; Daunorubicin; Dinoprostone; Disease Progression; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Male; Mice; Mice, Inbred NOD; Mice, SCID; RNA Interference; RNA, Small Interfering; Theophylline; Transplantation, Heterologous; Tretinoin | 2013 |