thapsigargin has been researched along with thionicotinamide-adenine-dinucleotide-phosphate* in 1 studies
1 other study(ies) available for thapsigargin and thionicotinamide-adenine-dinucleotide-phosphate
| Article | Year |
|---|---|
Nicotinate-adenine dinucleotide phosphate-induced Ca(2+)-release does not behave as a Ca(2+)-induced Ca(2+)-release system.
We investigated the dependence of nicotinate-adenine dinucleotide phosphate (NAADP)-induced Ca2+ release from intracellular stores of sea urchin egg homogenates, upon extravesicular Ca2+. In contrast to the Ca2+ release induced inositol 1',4',5'-triphosphate (IP3) or cyclic ADP-ribose (cADPR), the Ca2+ release induced by NAADP was completely independent of the free extravesicular Ca2+ over a wide range of concentrations (0-0.1 mM). The Ca2+ release triggered by either cADPR or IP3 was biphasically modulated by extravesicular Ca2+, and the Ca2+ release by these agents was abolished when the extravesicular Ca2+ was removed by chelation with 2 mM EGTA. On the other hand, NAADP-triggered Ca2+ release was not influenced by EGTA. These data indicate that while both cADPR and IP3 systems behave as functional Ca(2+)-induced Ca2+ release mechanisms, NAADP activates a Ca2+ release mechanism which is independent of the presence of extravesicular Ca2+. Therefore, the NAADP-sensitive Ca2+ release mechanisms may have a unique regulatory impact upon intracellular Ca2+ homoeostasis. Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cyclic ADP-Ribose; Egtazic Acid; Enzyme Inhibitors; Female; Gallic Acid; Kinetics; NADP; Ovum; Sea Urchins; Terpenes; Thapsigargin | 1996 |