thapsigargin has been researched along with petasin* in 1 studies
1 other study(ies) available for thapsigargin and petasin
| Article | Year |
|---|---|
S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis.
Eremophilanlactones isolated from roots of Petasites hybridus (L.) G.M. et Sch. (Asteraceae) and S-petasin have vasodilatory effects with pD(2) -log (EC(50)) values of 6.01+/-0.08, 5.24+/-0.10, 4.74+/-0.13, and 5.43+/-0.06 for S-petasin, the (Z)-3-methylthioacrylic ester of 2beta-hydroxy-8betaH-7(11)-eremophilene-12,8-olide, the angelic ester of 2beta-hydroxy-8alphaH-7(11)-eremophilene-12,8-olide, and the angelic ester of 2beta-hydroxy-8betaH-7(11)-eremophilene-12,8-olide, respectively, in the mesenteric arteries. The pD(2) values were somewhat lower for all compounds in aortic segments. The vasodilation was caused by a blockage of the voltage gated calcium channels. S-petasin, (Z)-3-methylthioacrylic ester of 2beta-hydroxy-8betaH-7(11)-eremophilene-12,8-olide, and the angelic ester of 2beta-hydroxy-8alphaH-7(11)-eremophilene-12,8-olide displayed similar potencies in inhibiting DNA synthesis in cardiomyocytes and vascular smooth muscle cells. Topics: Animals; Animals, Newborn; Aorta, Thoracic; Calcium Channel Blockers; Cells, Cultured; Data Interpretation, Statistical; DNA; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Lactones; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocytes, Cardiac; Myocytes, Smooth Muscle; Nucleic Acid Synthesis Inhibitors; Petasites; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Thapsigargin; Vasodilator Agents | 2008 |