thapsigargin and darodipine

thapsigargin has been researched along with darodipine* in 1 studies

Other Studies

1 other study(ies) available for thapsigargin and darodipine

Article	Year
Increase of empty pool-activated Ca2+ influx using an intracellular Ca2+ chelating agent. Biochemical and biophysical research communications, 1996, Jan-26, Volume: 218, Issue:3 We demonstrate here that stimulated 45Ca2+ influx in A7r5 vascular smooth muscle cells induced either by receptor activation with [Arg]8 vasopressin or by the SR-Ca(2+)-ATPase inhibitor thapsigargin was increased more than threefold if cells were preloaded with the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid). The increased influx is probably due to an attenuation of negative feedback of Ca2+ on its own entry accompanied by increased Ca2+ storage capacity of BAPTA-loaded cells leading to diminished cellular Ca2+ release. We propose that BAPTA preloading could be a useful approach to investigate receptor-induced Ca2+ influx. Topics: Animals; Arginine Vasopressin; Biological Transport; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Compartmentation; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoplasm; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Rats; Terpenes; Thapsigargin	1996

Article

Year

Increase of empty pool-activated Ca2+ influx using an intracellular Ca2+ chelating agent.

Biochemical and biophysical research communications, 1996, Jan-26, Volume: 218, Issue:3

We demonstrate here that stimulated 45Ca2+ influx in A7r5 vascular smooth muscle cells induced either by receptor activation with [Arg]8 vasopressin or by the SR-Ca(2+)-ATPase inhibitor thapsigargin was increased more than threefold if cells were preloaded with the intracellular calcium chelator BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid). The increased influx is probably due to an attenuation of negative feedback of Ca2+ on its own entry accompanied by increased Ca2+ storage capacity of BAPTA-loaded cells leading to diminished cellular Ca2+ release. We propose that BAPTA preloading could be a useful approach to investigate receptor-induced Ca2+ influx.

Topics: Animals; Arginine Vasopressin; Biological Transport; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Compartmentation; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoplasm; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Rats; Terpenes; Thapsigargin

1996