thapsigargin has been researched along with cinobufagin* in 1 studies
1 other study(ies) available for thapsigargin and cinobufagin
| Article | Year |
|---|---|
Investigation of cytotoxic effect of the bufanolide steroid compound cinobufagin and its related underlying mechanism in brain cell models.
Cinobufagin, a bufadienolide of toad venom of Bufo bufo gargarizans, is used as a cardiotonic, central nervous system (CNS) respiratory agent, as well as an analgesic and anesthetic. However, several research showed that bufadienolide has a few side effects on the CNS, such as breathlessness or coma. Although cinobufagin was shown to display pharmacological effects in various models, the toxic effect of cinobufagin is elusive in brain cell models. The aim of this study was to explore whether cinobufagin affected viability, Ca Topics: Amphibian Venoms; Animals; Astrocytes; Brain; Bufanolides; Bufo bufo; Calcium; Calcium Signaling; Cell Line; Cell Survival; Cytosol; Endoplasmic Reticulum; Homeostasis; Humans; Neurons; Reactive Oxygen Species; Thapsigargin; Type C Phospholipases | 2021 |