thapsigargin and butenolide

thapsigargin has been researched along with butenolide* in 1 studies

Other Studies

1 other study(ies) available for thapsigargin and butenolide

Article	Year
Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin. Organic & biomolecular chemistry, 2007, May-07, Volume: 5, Issue:9 Thapsigargin is a densely oxygenated guaianolide which displays potent sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) binding affinities. The total syntheses of designed unnatural analogues of this important natural product are described. This article constitutes the chemical synthesis behind an ongoing project. Rational modifications have been made to the lactone region of thapsigargin in order to obtain derivatives for future structure-activity relationship studies. Topics: 4-Butyrolactone; Drug Design; Enzyme Inhibitors; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin	2007

Article

Year

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.

Organic & biomolecular chemistry, 2007, May-07, Volume: 5, Issue:9

Thapsigargin is a densely oxygenated guaianolide which displays potent sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) binding affinities. The total syntheses of designed unnatural analogues of this important natural product are described. This article constitutes the chemical synthesis behind an ongoing project. Rational modifications have been made to the lactone region of thapsigargin in order to obtain derivatives for future structure-activity relationship studies.

Topics: 4-Butyrolactone; Drug Design; Enzyme Inhibitors; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin

2007