Compounds > tezosentan
Page last updated: 2024-09-04

tezosentan and indomethacin

tezosentan has been researched along with indomethacin in 6 studies

Compound Research Comparison

Studies
(tezosentan)		Trials
(tezosentan)		Recent Studies (post-2010)
(tezosentan)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
157293329,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomytezosentan (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dekker, MM; Duncker, DJ; Houweling, B; Merkus, D1
Alves, RS; Amora, DN; Barbosa, PS; Fonteles, MC; Havt, A; Martins, AM; Martins, RD; Menezes, DB; Monteiro, HS; Nascimento, NR; Rocha, VL; Toyama, MH1
Boomsma, F; Duncker, DJ; Houweling, B; Merkus, D; Sorop, O; van den Meiracker, AH1
Alves, RS; Barbosa, PSF; Costa Martins, AM; Jorge, RJB; Martins, RD; Monteiro, HSA; Silva Neto, AGD; Toyama, MH1

Other Studies

6 other study(ies) available for tezosentan and indomethacin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Nitric oxide blunts the endothelin-mediated pulmonary vasoconstriction in exercising swine.
    The Journal of physiology, 2005, Oct-15, Volume: 568, Issue:Pt 2

    Topics: Animals; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelins; Female; Heart Rate; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxygen Consumption; Physical Exertion; Pulmonary Circulation; Pyridines; Swine; Tetrazoles; Vasoconstriction; Vasodilator Agents

2005
The role of indomethacin and tezosentan on renal effects induced by Bothrops moojeni Lys49 myotoxin I.
    Toxicon : official journal of the International Society on Toxinology, 2006, Jun-15, Volume: 47, Issue:8

    Topics: Animals; Bothrops; Crotalid Venoms; Endothelins; Group II Phospholipases A2; Indomethacin; Kidney; Male; Phospholipases A; Pyridines; Rats; Rats, Wistar; Reptilian Proteins; Splanchnic Circulation; Tetrazoles; Vasodilator Agents

2006
NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:5

    Topics: Animals; Cardiac Output; Cyclooxygenase Inhibitors; Drug Interactions; Endothelin Receptor Antagonists; Endothelins; Female; Heart Rate; Indomethacin; Male; Nitric Oxide; Nitroarginine; Oxygen Consumption; Physical Conditioning, Animal; Physical Exertion; Prostaglandins; Pyridines; Sus scrofa; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2006
Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement.
    Toxicon : official journal of the International Society on Toxinology, 2017, Volume: 138

    Topics: Animals; Cnidarian Venoms; Endothelins; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Mesenteric Arteries; Prostaglandins; Pyridines; Rats, Wistar; Sea Anemones; Tetrazoles; Vascular Resistance

2017