Page last updated: 2024-09-04

tezosentan and endothelin-1

tezosentan has been researched along with endothelin-1 in 39 studies

Compound Research Comparison

Studies (tezosentan)	Trials (tezosentan)	Recent Studies (post-2010) (tezosentan)	Studies (endothelin-1)	Trials (endothelin-1)	Recent Studies (post-2010) (endothelin-1)
157	29	33	12,740	632	3,394

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.56)	18.2507
2000's	30 (76.92)	29.6817
2010's	8 (20.51)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Breu, V; Clozel, JP; Clozel, M; Coassolo, P; Hess, P; Löffler, BM; Ramuz, H; Roux, S	1
Duchman, SM; Kalra, D; Thohan, V; Torre-Amione, G	1
Bozkurt, B; Durand, J; Kobrin, I; Mann, DL; Pratt, CM; Torre-Amione, G; Young, JB	1
Robinson, AV; Schulak, JA; Stowe, NT; Wilhelm, SM	1
Bertel, O; Cotter, G; Guyene, TT; Kiowski, W; Kobrin, I; Reisin, L; Schalcher, C	1
Aneman, A; Burgener, D; Hadengue, A; Jolliet, P; Laesser, M; Oi, Y; Strasser, S; Treggiari-Venzi, M	1
Cheng, TO	1
Budihna, MV; Bunc, M; Drevensek, G; Kirbis, S; Suput, D; Zitko, M	1
Adams, KF; Frey, A; Gattis, WA; Gheorghiade, M; O'Connor, CM; Shah, MR	1
Boomsma, F; Duncker, DJ; Houweling, B; Merkus, D; Mirza, A; van den Meiracker, AH	1
Bostad, L; Grong, K; Gudmundsson, FF; Myking, OL; Svanes, K; Viste, A	1
Beresewicz, A; Boemke, W; Duda, M; Kurzelewski, M; Stanley, WC	1
Konrad, D; Oldner, A; Rossi, P; Wanecek, M	1
Konrad, D; Oldner, A; Rossi, P; Rudehill, A; Wanecek, M; Weitzberg, E	1
Boomsma, F; Duncker, DJ; Houweling, B; Merkus, D; van den Meiracker, AH	1
Fineman, JR; Fitzgerald, RK; Johengen, MJ; Oishi, P; Ovadia, B; Reinhartz, O; Ross, GA	1
Lorts, A; Shanley, TP	1
Andreasen, T; Bjertnaes, L; Ingebretsen, OC; Kirov, M; Kuklin, V; Sovershaev, M; Ytrehus, K	1
Jackson, DC; Skovgaard, N; Wang, T; Warren, DE	1
Dingemanse, J; Gunawardena, KA; van Giersbergen, PL	1
Albu, G; Barazzone-Argiroffo, C; Beghetti, M; Donati, Y; Habre, W; Lele, E; Peták, F; Ruchonnet-Metrailler, I; Tolsa, JF	1
Edston, E; Oldner, A; Walther, SM; Wang, J; Winskog, C	1
Boomsma, F; Duncker, DJ; Houweling, B; Merkus, D; Sorop, O	1
Haney, M; Johansson, G; Konrad, D; Oldner, A; Wanecek, M; Weitzberg, E	1
Dingemanse, J; Jalan, R; Moore, K; Wong, F	1
Arner, A; Boels, PJ; Oldner, A; Persson, B; Rossi, P; Weitzberg, E	1
Dodds, CM; Dodds, RA; Iribarne, M; Ogawa, L; Suburo, AM; Torbidoni, V	1
Korolkiewicz, RP; Sein-Anand, J; Sokołowska-Wojdyło, M; Umer, A; Włodarkiewicz, A; Ługowska-Umer, H	1
Aneman, A; Burgener, D; Hadengue, A; Laesser, M; Strasser, S; Treggiari, MM	1
Cotter, G; Dittrich, H; Felker, GM; Metra, M; Milo-Cotter, O; Teerlink, JR; Voors, AA; Weatherley, B	1
Dingemanse, J; Halabi, A; van Giersbergen, PL	1
Andersson, A; Fenhammar, J; Frithiof, R; Hjelmqvist, H; Sollevi, A; Weitzberg, E	1
Bosch, J; Chiossi, E; Dingemanse, J; Dudley, FJ; Garcia-Pagan, JC; Jalan, R; Jessic, R; Kusic-Pajic, A; Lebrec, D; Mookerjee, RP; Moreau, R; Van Giersbergen, PL	1
Koivula, MK; Lehenkari, P; Leskelä, HV; Peltonen, T; Ruskoaho, H; Taskinen, P; Vuolteenaho, O	1
Aggarwal, S; Azakie, A; Black, SM; Datar, SA; Fineman, JR; Hou, Y; Kumar, S; Oishi, PE; Rafikov, R; Sharma, S	1
Aggarwal, S; Black, SM; Fineman, JR; Hou, Y; Kangath, A; Kumar, S; Pardo, D; Rafikov, R	1
Halldorsdottir, H; Herwald, H; Lindbom, L; Oldner, A; Persson, BP; Rossi, P; Weitzberg, E	1
Goraca, A; Kleniewska, P; Kolodziejczyk, M; Kowalczyk, A; Skibska, B	1
Abukar, Y; May, CN; Ramchandra, R	1

Reviews

3 review(s) available for tezosentan and endothelin-1

Article	Year
Endothelin-1: a new target of therapeutic intervention for the treatment of heart failure. Current opinion in cardiology, 2000, Volume: 15, Issue:3 Topics: Animals; Disease Models, Animal; Disease Progression; Dogs; Drug Evaluation, Preclinical; Endothelin-1; Heart Failure; Hemodynamics; Humans; Oxygen Consumption; Prognosis; Pyridines; Rabbits; Rats; Survival Analysis; Tetrazoles	2000
Vasodilators in the treatment of acute heart failure: what we know, what we don't. Heart failure reviews, 2009, Volume: 14, Issue:4 Topics: Acute Disease; Atrial Natriuretic Factor; Benzoates; Elapid Venoms; Endothelin-1; Heart Failure; Humans; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitrates; Peptide Fragments; Prognosis; Pyridines; Receptors, Endothelin; Relaxin; Tetrazoles; Vasoconstriction; Vasodilator Agents	2009
The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis. Archivum immunologiae et therapiae experimentalis, 2015, Volume: 63, Issue:1 Topics: Animals; Bosentan; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Humans; Inflammation; Lipopolysaccharides; NF-kappa B; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Reactive Oxygen Species; Sepsis; Signal Transduction; Sulfonamides; Superoxides; Tetrazoles	2015

Trials

7 trial(s) available for tezosentan and endothelin-1

Article	Year
Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. Circulation, 2001, Feb-20, Volume: 103, Issue:7 Topics: Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Failure; Heart Function Tests; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Pulmonary Wedge Pressure; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Tetrazoles; Treatment Outcome; Vascular Resistance; Vasodilator Agents	2001
The dual endothelin receptor antagonist tezosentan acutely improves hemodynamic parameters in patients with advanced heart failure. American heart journal, 2001, Volume: 142, Issue:2 Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Epinephrine; Female; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Norepinephrine; Prospective Studies; Pyridines; Tetrazoles; Vasodilator Agents	2001
Tezosentan in patients with acute heart failure and acute coronary syndromes: design of the fourth Randomized Intravenous Tezosentan Study (RITZ-4). American heart journal, 2003, Volume: 145, Issue:2 Suppl Topics: Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Humans; Myocardial Ischemia; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Recurrence; Tetrazoles; Treatment Outcome; Vasodilator Agents	2003
Comparison of the pharmacokinetics, pharmacodynamics and tolerability of tezosentan between caucasian and Japanese subjects. British journal of clinical pharmacology, 2006, Volume: 61, Issue:4 Topics: Adult; Area Under Curve; Asian People; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Japan; Male; Middle Aged; Pyridines; Tetrazoles; Time Factors; White People	2006
Lack of renal improvement with nonselective endothelin antagonism with tezosentan in type 2 hepatorenal syndrome. Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:1 Topics: Endothelin-1; Hemodynamics; Hepatorenal Syndrome; Humans; Kidney; Kidney Function Tests; Liver Cirrhosis; Male; Middle Aged; Pilot Projects; Pyridines; Sodium; Tetrazoles; Treatment Failure; Water	2008
Influence of liver cirrhosis on the pharmacokinetics, pharmacodynamics, and safety of tezosentan. Journal of clinical pharmacology, 2009, Volume: 49, Issue:4 Topics: Adult; Bilirubin; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin-1; Female; Humans; Infusions, Intravenous; Liver Cirrhosis; Male; Middle Aged; Placebos; Pyridines; Tetrazoles; Vasodilator Agents	2009
Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis. European journal of clinical pharmacology, 2012, Volume: 68, Issue:5 Topics: Antihypertensive Agents; Double-Blind Method; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Rate; Hemodynamics; Humans; Hypertension, Portal; Infusions, Parenteral; Liver; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Metabolic Clearance Rate; Middle Aged; Pyridines; Severity of Illness Index; Splanchnic Circulation; Tetrazoles; Vasodilator Agents	2012

Other Studies

29 other study(ies) available for tezosentan and endothelin-1

Article	Year
Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2 Topics: Acute Kidney Injury; Animals; Aorta, Thoracic; Cell Adhesion; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Humans; In Vitro Techniques; Macaca fascicularis; Macaca mulatta; Male; Microsomes; Pyridines; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Spodoptera; Tetrazoles; Trachea	1999
The use of the endothelin receptor antagonist, tezosentan, before or after renal ischemia protects renal function. Transplantation, 2001, Jan-27, Volume: 71, Issue:2 Topics: Animals; Endothelin Receptor Antagonists; Endothelin-1; Glomerular Filtration Rate; Immunohistochemistry; Ischemia; Kidney; Kidney Tubular Necrosis, Acute; Male; Pyridines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Reperfusion Injury; Tetrazoles; Time Factors	2001
Endothelin-1 blockade corrects mesenteric hypoperfusion in a porcine low cardiac output model. Critical care medicine, 2001, Volume: 29, Issue:8 Topics: Animals; Blood Gas Analysis; Cardiac Output, Low; Endothelin Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hydrogen-Ion Concentration; Male; Oximetry; Perfusion; Pyridines; Splanchnic Circulation; Swine; Tetrazoles; Vasoconstriction; Vasodilator Agents	2001
Endothelin receptor blockade in congestive heart failure. Circulation, 2001, Oct-30, Volume: 104, Issue:18 Topics: Acute Disease; Antihypertensive Agents; Bosentan; Chronic Disease; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelin-1; Exercise Tolerance; Heart Failure; Hemodynamics; Humans; Phenylpropionates; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Treatment Outcome; Vasodilator Agents	2001
Tezosentan inhibits both equinatoxin II and endotelin-1 induced contractions of isolated porcine coronary artery in a similar way. Journal of natural toxins, 2002, Volume: 11, Issue:3 Topics: Animals; Cnidarian Venoms; Coronary Vessels; Endothelin-1; Endothelium; Marine Toxins; Pyridines; Receptors, Endothelin; Sea Anemones; Swine; Tetrazoles; Vasodilator Agents	2002
Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation. Cardiovascular research, 2003, Sep-01, Volume: 59, Issue:3 Topics: Animals; Blood Circulation; Coronary Circulation; Endothelin-1; Female; Male; Physical Conditioning, Animal; Pulmonary Circulation; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Swine; Tetrazoles; Thiazoles; Vasoconstriction; Vasodilation; Vasodilator Agents	2003
Effects of the endothelin-1 receptor antagonist tezosentan on renal blood flow and diuresis during prolonged increased intra-abdominal pressure. The Journal of surgical research, 2003, Volume: 115, Issue:1 Topics: Abdomen; Aldosterone; Animals; Blood Flow Velocity; Diuresis; Endothelin-1; Female; Hemodynamics; Kidney Cortex; Liver; Male; Pressure; Pyridines; Renal Circulation; Renin; Swine; Tetrazoles; Vascular Resistance	2003
Nitric oxide synthase inhibition and elevated endothelin increase oxygen consumption but do not affect glucose and palmitate oxidation in the isolated rat heart. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 1 Topics: Animals; Coronary Circulation; Diastole; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Glucose; Heart Rate; Heart Ventricles; Lactic Acid; Male; Myocardium; Nitric Oxide Synthase; omega-N-Methylarginine; Oxygen Consumption; Palmitates; Pyridines; Rats; Receptor, Endothelin A; Receptor, Endothelin B; Tetrazoles; Tritium; Ventricular Function; Water	2004
Tezosentan counteracts endotoxin-induced pulmonary edema and improves gas exchange. Shock (Augusta, Ga.), 2004, Volume: 21, Issue:6 Topics: Acid-Base Equilibrium; Animals; Endothelin Receptor Antagonists; Endothelin-1; Endotoxins; Female; Hemodynamics; Hemoglobins; Male; Pulmonary Edema; Pulmonary Gas Exchange; Pyridines; Sus scrofa; Tetrazoles	2004
Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock. Critical care medicine, 2004, Volume: 32, Issue:5 Topics: Animals; Cardiac Catheterization; Cardiovascular System; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Monitoring; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Infusions, Intravenous; Pyridines; Resuscitation; Shock, Septic; Stroke Volume; Swine; Tetrazoles; Troponin I; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left	2004
Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:2 Topics: Animals; Arterioles; Coronary Circulation; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Male; Myocardial Infarction; Oxygen; Pyridines; Sus scrofa; Tetrazoles; Vasoconstriction; Vasodilator Agents	2005
Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2004, Volume: 5, Issue:6 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acute Disease; Animals; Animals, Newborn; Chronic Disease; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Hypertension, Pulmonary; Injections, Intra-Arterial; Pulmonary Circulation; Pyridines; Random Allocation; Sheep; Tetrazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2004
Tezosentan, another selective selection for pulmonary hypertension, or not? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2004, Volume: 5, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Hypertension, Pulmonary; Pulmonary Circulation; Pyridines; Tetrazoles; Vasodilation; Vasodilator Agents	2004
Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. Critical care (London, England), 2005, Volume: 9, Issue:3 Topics: Animals; Endothelin A Receptor Antagonists; Endothelin-1; Endotoxemia; Enzyme Activation; Escherichia coli Infections; Interleukin-8; Protein Kinase C; Pyridines; Respiratory Distress Syndrome; Sheep; Tetrazoles; Tumor Necrosis Factor-alpha; Vasodilator Agents	2005
Endothelin-1 causes systemic vasodilatation in anaesthetised turtles (Trachemys scripta) through activation of ETB-receptors. The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 19 Topics: Analysis of Variance; Animals; Blood Circulation; Blood Pressure; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Oligopeptides; Peptide Fragments; Piperidines; Pyridines; Receptors, Endothelin; Stroke Volume; Tetrazoles; Turtles; Vasodilation	2005
The role of endothelin-1 in hyperoxia-induced lung injury in mice. Respiratory research, 2006, Mar-27, Volume: 7 Topics: Airway Resistance; Animals; Endothelin-1; Female; Hyperoxia; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Models, Biological; Pyridines; Receptors, Endothelin; Tetrazoles; Time Factors; Vasodilator Agents	2006
Effects of endothelin receptor antagonism on acute lung injury induced by chlorine gas. Critical care medicine, 2006, Volume: 34, Issue:6 Topics: Animals; Chlorine; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Female; Lung Compliance; Pyridines; Respiratory Distress Syndrome; Swine; Tetrazoles; Treatment Outcome; Vascular Resistance; Vasodilator Agents	2006
Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction. The Journal of physiology, 2006, Jul-15, Volume: 574, Issue:Pt 2 Topics: Animals; Blood Pressure; Consciousness; Endothelin Receptor Antagonists; Endothelin-1; Female; Hemodynamics; Hypertension, Pulmonary; Male; Myocardial Infarction; Physical Conditioning, Animal; Pulmonary Circulation; Pyridines; Receptors, Endothelin; Rest; Swine; Tetrazoles; Vasoconstriction; Vasodilator Agents	2006
Cardiac effects of endothelin receptor antagonism in endotoxemic pigs. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:2 Topics: Animals; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endotoxemia; Endotoxins; Female; Heart Rate; Myocardial Contraction; Oxygen Consumption; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Sus scrofa; Tetrazoles; Time Factors; Ventricular Function, Left; Ventricular Pressure	2007
Endotoxemic pulmonary hypertension is largely mediated by endothelin-induced venous constriction. Intensive care medicine, 2008, Volume: 34, Issue:5 Topics: Animals; Ciprofloxacin; Endothelin-1; Female; Hypertension, Pulmonary; Lipopolysaccharides; Lung; Male; Pyridines; Respiratory Distress Syndrome; Sepsis; Swine; Tetrazoles; Vascular Resistance; Vasoconstriction; Vasodilator Agents	2008
Blockade of endothelinergic receptors prevents development of proliferative vitreoretinopathy in mice. The American journal of pathology, 2008, Volume: 172, Issue:4 Topics: Animals; Endopeptidases; Endothelin B Receptor Antagonists; Endothelin-1; Fluorescent Antibody Technique; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Injections; Mice; Mice, Inbred C57BL; Pyridines; Receptor, Endothelin B; Retina; Retinal Detachment; RNA, Messenger; Tetrazoles; Vitreoretinopathy, Proliferative	2008
Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats. Pharmacological research, 2008, Volume: 57, Issue:6 Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbachol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Ether; Evans Blue; Gastrointestinal Motility; Male; Muscarinic Agonists; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; Surgical Procedures, Operative; Tetrazoles	2008
Tezosentan normalizes hepatomesenteric perfusion in a porcine model of cardiac tamponade. Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:2 Topics: Animals; Carbon Dioxide; Cardiac Output, Low; Cardiac Tamponade; Drug Evaluation, Preclinical; Endothelin Receptor Antagonists; Endothelin-1; Female; Lactates; Liver Circulation; Male; Models, Animal; Oxygen; Oxygen Consumption; Pyridines; Splanchnic Circulation; Sus scrofa; Tetrazoles; Vascular Resistance; Vasoconstriction	2009
Endothelin-mediated gut microcirculatory dysfunction during porcine endotoxaemia. British journal of anaesthesia, 2010, Volume: 105, Issue:5 Topics: Animals; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endotoxemia; Female; Hypertension, Pulmonary; Ileum; Intestinal Mucosa; Isoxazoles; Microcirculation; Pyridines; Receptor, Endothelin A; Receptor, Endothelin B; Splanchnic Circulation; Sulfones; Sus scrofa; Tetrazoles; Vasodilator Agents	2010
Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves. The Journal of heart valve disease, 2012, Volume: 21, Issue:1 Topics: Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Cells, Cultured; Drug Repositioning; Endothelin A Receptor Antagonists; Endothelin-1; Female; Humans; Inflammation; Lipid Metabolism; Male; Middle Aged; Pyridines; Receptor, Endothelin A; Tetrazoles; Vasodilator Agents	2012
Tezosentan increases nitric oxide signaling via enhanced hydrogen peroxide generation in lambs with surgically induced acute increases in pulmonary blood flow. Journal of cellular biochemistry, 2013, Volume: 114, Issue:2 Topics: Animals; Catalase; Endothelial Cells; Endothelin-1; Hemodynamics; Hydrogen Peroxide; Lung; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Pulmonary Artery; Pyridines; Receptor, Endothelin A; Regional Blood Flow; Sheep, Domestic; Signal Transduction; Tetrazoles	2013
Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167. Free radical biology & medicine, 2014, Volume: 67 Topics: Animals; Catalase; Chlorocebus aethiops; COS Cells; Endothelial Cells; Endothelin-1; Escherichia coli; Gene Expression; Hydrogen Peroxide; Mutagenesis, Site-Directed; Oxidation-Reduction; Phosphorylation; Primary Cell Culture; Protein Kinase C-delta; Protein Kinase Inhibitors; Protein Multimerization; Pulmonary Artery; Pyridines; Recombinant Proteins; Serine; Sheep; Tetrazoles; Vasodilator Agents	2014
Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema? Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5 Topics: Animals; Antimicrobial Cationic Peptides; Blood Proteins; Capillary Leak Syndrome; Carrier Proteins; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endotoxemia; Endotoxins; Extravascular Lung Water; Female; Hemodynamics; Inflammation; Infusions, Intravenous; Leukocyte Count; Male; Neutrophil Activation; Pulmonary Edema; Pyridines; Random Allocation; Receptor, Endothelin B; Sus scrofa; Swine; Tetrazoles; Viper Venoms	2014
Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure. American journal of physiology. Regulatory, integrative and comparative physiology, 2016, Jan-01, Volume: 310, Issue:1 Topics: Animals; Arterial Pressure; Baroreflex; Biomarkers; Cardiac Pacing, Artificial; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart; Heart Failure; Heart Rate; Hemodynamics; Infusions, Intravenous; Pyridines; Sheep; Signal Transduction; Stroke Volume; Sympathetic Nervous System; Tetrazoles; Time Factors; Up-Regulation	2016