Page last updated: 2024-09-04

tezosentan and clazosentan

tezosentan has been researched along with clazosentan in 3 studies

Compound Research Comparison

Studies (tezosentan)	Trials (tezosentan)	Recent Studies (post-2010) (tezosentan)	Studies (clazosentan)	Trials (clazosentan)	Recent Studies (post-2010) (clazosentan)
157	29	33	94	33	61

Protein Interaction Comparison

Protein	Taxonomy	tezosentan (IC50)	clazosentan (IC50)
Endothelin receptor type B	Homo sapiens (human)		0.175
Endothelin-1 receptor	Homo sapiens (human)		0.0017

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bolli, MH; Boss, C; Gatfield, J	1
Markos, F; Rae, MG; Ruane-O'Hora, T	1
Dingemanse, J; Krause, A; Lehr, T; Volz, AK	1

Reviews

1 review(s) available for tezosentan and clazosentan

Article	Year
From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective. Bioorganic & medicinal chemistry letters, 2016, 08-01, Volume: 26, Issue:15 Topics: Bosentan; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pyrimidines; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides	2016

Other Studies

2 other study(ies) available for tezosentan and clazosentan

Article	Year
Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:8 Topics: Anesthesia; Animals; Blood Pressure; Dioxanes; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Female; Heart Rate; Iliac Artery; Pulsatile Flow; Pyridines; Pyrimidines; Stress, Mechanical; Sulfonamides; Swine; Tetrazoles; Vasoconstriction; Vasodilator Agents	2011
Target-Mediated Population Pharmacokinetic Modeling of Endothelin Receptor Antagonists. Pharmaceutical research, 2019, Dec-10, Volume: 37, Issue:1 Topics: Bosentan; Dioxanes; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Humans; Infusions, Intravenous; Male; Models, Biological; Nonlinear Dynamics; Pyridines; Pyrimidines; Receptors, Endothelin; Sulfonamides; Tandem Mass Spectrometry; Tetrazoles	2019

Article

Year

Effect of clazosentan, a selective endothelin A receptor antagonist, and tezosentan, a dual endothelin A/B antagonist, on pulsatile shear stress induced constriction of the iliac in the anaesthetized pig.

Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:8

Topics: Anesthesia; Animals; Blood Pressure; Dioxanes; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Female; Heart Rate; Iliac Artery; Pulsatile Flow; Pyridines; Pyrimidines; Stress, Mechanical; Sulfonamides; Swine; Tetrazoles; Vasoconstriction; Vasodilator Agents

2011

Target-Mediated Population Pharmacokinetic Modeling of Endothelin Receptor Antagonists.

Pharmaceutical research, 2019, Dec-10, Volume: 37, Issue:1

Topics: Bosentan; Dioxanes; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Humans; Infusions, Intravenous; Male; Models, Biological; Nonlinear Dynamics; Pyridines; Pyrimidines; Receptors, Endothelin; Sulfonamides; Tandem Mass Spectrometry; Tetrazoles

2019