Compounds > tezosentan
Page last updated: 2024-09-04

tezosentan and carvedilol

tezosentan has been researched along with carvedilol in 6 studies

Compound Research Comparison

Studies
(tezosentan)		Trials
(tezosentan)		Recent Studies (post-2010)
(tezosentan)		Studies
(carvedilol)		Trials
(carvedilol)		Recent Studies (post-2010) (carvedilol)
15729332,9336801,052

Protein Interaction Comparison

ProteinTaxonomytezosentan (IC50)carvedilol (IC50)
Solute carrier family 22 member 2Homo sapiens (human)7.5
Solute carrier family 22 member 1 Homo sapiens (human)3.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.115
Potassium channel subfamily K member 2Homo sapiens (human)1.6
Beta-2 adrenergic receptorHomo sapiens (human)0.0002
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.538
ATP-dependent translocase ABCB1Homo sapiens (human)5.7333
Beta-1 adrenergic receptorHomo sapiens (human)0.0002
Alpha-2A adrenergic receptorHomo sapiens (human)0.106
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1193
Beta-3 adrenergic receptorHomo sapiens (human)0.0042
D(2) dopamine receptorHomo sapiens (human)0.146
Alpha-2B adrenergic receptorHomo sapiens (human)0.094
Alpha-2C adrenergic receptorHomo sapiens (human)0.09
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0058
D(1A) dopamine receptorHomo sapiens (human)1.498
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.538
Alpha-1D adrenergic receptorHomo sapiens (human)0.0018
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.115
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.0058
Sodium-dependent serotonin transporterHomo sapiens (human)0.221
D(3) dopamine receptorHomo sapiens (human)0.577
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
5-hydroxytryptamine receptor 6Homo sapiens (human)1.519
Potassium channel subfamily K member 10Homo sapiens (human)7.6
Sodium-dependent dopamine transporter Homo sapiens (human)0.845
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.2346
Cytochrome P450 1B1Homo sapiens (human)1.1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1193

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (83.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
SoRelle, R1
Clark, A; Cleland, JG; Crabbe, S; Ford, S; Houghton, T; Louis, A; Thackray, S1
Cherubini, A; Di Lenarda, A; Perkan, A; Salvatore, L; Sinagra, G1
Clark, AL; Cleland, JG; Coletta, AP; Seymour, AM1

Reviews

2 review(s) available for tezosentan and carvedilol

ArticleYear
Clinical Trials Update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001.
    European journal of heart failure, 2001, Volume: 3, Issue:3

    Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Cachexia; Carbazoles; Carboxylic Acids; Carvedilol; Cholesterol; Cytokines; Endothelins; Heart Failure; Humans; Indans; Injections, Intravenous; Myocardial Infarction; Propanolamines; Pyridines; Tetrazoles; United States; Vasodilator Agents

2001
[Treatment of heart failure: an update].
    Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2002, Volume: 3, Issue:7

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antidiuretic Hormone Receptor Antagonists; Antihypertensive Agents; Benzazepines; Bosentan; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Defibrillators, Implantable; Double-Blind Method; Heart Failure; Heart-Assist Devices; Humans; Metoprolol; Multicenter Studies as Topic; Placebos; Propanolamines; Prospective Studies; Pyridines; Quality of Life; Randomized Controlled Trials as Topic; Sulfonamides; Tetrazoles; Valine; Valsartan; Vasodilator Agents

2002

Trials

1 trial(s) available for tezosentan and carvedilol

ArticleYear
Clinical Trials Update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001.
    European journal of heart failure, 2001, Volume: 3, Issue:3

    Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Cachexia; Carbazoles; Carboxylic Acids; Carvedilol; Cholesterol; Cytokines; Endothelins; Heart Failure; Humans; Indans; Injections, Intravenous; Myocardial Infarction; Propanolamines; Pyridines; Tetrazoles; United States; Vasodilator Agents

2001

Other Studies

4 other study(ies) available for tezosentan and carvedilol

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
50th Annual scientific sessions of the American college of cardiology.
    Circulation, 2001, Apr-10, Volume: 103, Issue:14

    Topics: Adrenergic alpha-Antagonists; Angina Pectoris; Carbazoles; Carvedilol; Fibroblast Growth Factor 2; Genetic Therapy; Heart Diseases; Humans; Intermittent Claudication; Propanolamines; Pyridines; Tetrazoles

2001
Clinical trials update from the European Society of Cardiology Heart Failure meeting: COMET, COMPANION, Tezosentan and SHAPE.
    European journal of heart failure, 2003, Volume: 5, Issue:4

    Topics: Adrenergic beta-Antagonists; Carbazoles; Cardiac Pacing, Artificial; Carvedilol; Defibrillators, Implantable; Endpoint Determination; Health Education; Heart Failure; Hemodynamics; Humans; Metoprolol; Propanolamines; Pyridines; Randomized Controlled Trials as Topic; Tetrazoles; Treatment Outcome; Vasodilator Agents

2003