Page last updated: 2024-09-04

tezosentan and bq 123

tezosentan has been researched along with bq 123 in 5 studies

Compound Research Comparison

Studies
(tezosentan)
Trials
(tezosentan)
Recent Studies (post-2010)
(tezosentan)
Studies
(bq 123)
Trials
(bq 123)
Recent Studies (post-2010) (bq 123)
15729331,39163152

Protein Interaction Comparison

ProteinTaxonomytezosentan (IC50)bq 123 (IC50)
Endothelin-1 receptorHomo sapiens (human)0.017
Endothelin-1 receptorRattus norvegicus (Norway rat)0.014

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berens, KL; Blok, N; Bourgoyne, AR; Brock, TA; Bui, H; Decker, ER; Dixon, RA; Holland, GW; Knowles, V; Wang, J; Wu, C; You, TJ1
Al-Jiffry, BO; Saccone, GT; Toouli, J1
Lüscher, TF; Spieker, LE1
Korolkiewicz, RP; Sein-Anand, J; Sokołowska-Wojdyło, M; Umer, A; Włodarkiewicz, A; Ługowska-Umer, H1
Goraca, A; Kleniewska, P; Kolodziejczyk, M; Kowalczyk, A; Skibska, B1

Reviews

2 review(s) available for tezosentan and bq 123

ArticleYear
Will endothelin receptor antagonists have a role in heart failure?
    The Medical clinics of North America, 2003, Volume: 87, Issue:2

    Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome

2003
The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.
    Archivum immunologiae et therapiae experimentalis, 2015, Volume: 63, Issue:1

    Topics: Animals; Bosentan; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Humans; Inflammation; Lipopolysaccharides; NF-kappa B; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Reactive Oxygen Species; Sepsis; Signal Transduction; Sulfonamides; Superoxides; Tetrazoles

2015

Trials

1 trial(s) available for tezosentan and bq 123

ArticleYear
Discovery, modeling, and human pharmacokinetics of N-(2-acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl)thiophene-2-carboxamide (TBC3711), a second generation, ETA selective, and orally bioavailable endothelin antagonist.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Humans; Isoxazoles; Ligands; Male; Models, Molecular; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Structure-Activity Relationship; Sulfones

2004

Other Studies

2 other study(ies) available for tezosentan and bq 123

ArticleYear
Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.
    Journal of gastroenterology and hepatology, 2002, Volume: 17, Issue:3

    Topics: Adult; Animals; Calcium; Endothelin Receptor Antagonists; Endothelin-3; Female; Gallbladder; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opossums; Peptides, Cyclic; Piperidines; Pyridines; Receptors, Endothelin; Tetrazoles; Tetrodotoxin

2002
Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats.
    Pharmacological research, 2008, Volume: 57, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Carbachol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Ether; Evans Blue; Gastrointestinal Motility; Male; Muscarinic Agonists; Oligopeptides; Peptides, Cyclic; Piperidines; Pyridines; Rats; Rats, Wistar; Reperfusion Injury; Surgical Procedures, Operative; Tetrazoles

2008