Compounds > tetraphenylphosphonium
Page last updated: 2024-09-05

tetraphenylphosphonium and verapamil

tetraphenylphosphonium has been researched along with verapamil in 6 studies

Compound Research Comparison

Studies
(tetraphenylphosphonium)		Trials
(tetraphenylphosphonium)		Recent Studies (post-2010)
(tetraphenylphosphonium)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
43803917,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomytetraphenylphosphonium (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ1
Bibi, E; Gros, P; Kaback, HR; Talbot, F; Tang-Wai, D1
Erdreich, A; Rahamimoff, H1
Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M1
Konings, WN; Koole, LA; Putman, M; van Veen, HW1
Aínsa, JA; Bailo, R; Rodrigues, L; Villellas, C; Viveiros, M1

Other Studies

6 other study(ies) available for tetraphenylphosphonium and verapamil

ArticleYear
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
    Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2

    Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors

2001
Lipophilic cations: a group of model substrates for the multidrug-resistance transporter.
    Biochemistry, 1992, Feb-25, Volume: 31, Issue:7

    Topics: Adenosine Triphosphate; Animals; Arsenicals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cations; Cell Survival; CHO Cells; Cricetinae; Electrophoresis, Polyacrylamide Gel; Gramicidin; Membrane Glycoproteins; Mutation; Onium Compounds; Organophosphorus Compounds; Substrate Specificity; Trityl Compounds; Verapamil

1992
The inhibition of Ca uptake in cardiac membrane vesicles by verapamil.
    Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14

    Topics: Animals; Biological Transport, Active; Calcium; Carrier Proteins; Cattle; In Vitro Techniques; Membrane Potentials; Myocardium; Onium Compounds; Organophosphorus Compounds; Sarcolemma; Sodium-Calcium Exchanger; Verapamil

1984
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
    Molecular biology of the cell, 1996, Volume: 7, Issue:10

    Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine

1996
The secondary multidrug transporter LmrP contains multiple drug interaction sites.
    Biochemistry, 1999, Oct-19, Volume: 38, Issue:42

    Topics: Bacterial Proteins; Benzimidazoles; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Fluorescent Dyes; Kinetics; Lactococcus lactis; Lipid Bilayers; Membrane Proteins; Membrane Transport Proteins; Nicardipine; Onium Compounds; Organophosphorus Compounds; Phospholipids; Quinine; Spectrometry, Fluorescence; Verapamil; Vinblastine; Vincristine

1999
Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Acriflavine; Anti-Infective Agents, Local; Antineoplastic Agents; Antitubercular Agents; Bacterial Proteins; Cetrimonium; Cetrimonium Compounds; Drug Resistance, Bacterial; Enzyme Inhibitors; Ethidium; Gene Knockout Techniques; Isoniazid; Membrane Transport Proteins; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitriles; Onium Compounds; Organophosphorus Compounds; Phenazines; Verapamil

2013