tetramyristoyl-cardiolipin and 1-2-dipalmitoylphosphatidylglycerol

Phosphatidylglycerol and cardiolipin represent the most abundant anionic phospholipid components of cytoplasmic bacterial membranes and thus are used as constituents for membrane mimetic systems. In this study, we have characterized the temperature dependent phase behaviour of the binary system dipalmitoyl-phosphatidylglycerol (DPPG) and tetramyristoyl-cardiolipin (TMCL) using microcalorimetry and X-ray scattering techniques. Both lipids exhibited a very similar main transition temperature ( approximately 41 degrees C), showing a minimum (39.4 degrees C) for the binary mixtures at X(DPPG)=0.8, and exhibited low-temperature phase transitions, which were abolished by incorporation of small amounts (

Topics: Calorimetry, Differential Scanning; Cardiolipins; Cell Membrane; Gram-Positive Bacteria; Phase Transition; Phosphatidylglycerols; X-Ray Diffraction