tetramic-acid and thiazolyl-blue

Six new tetramic acids derivatives, penicillenols A(1), A(2), B(1), B(2), C(1), and C(2) (1-6), together with citrinin, phenol A acid, phenol A, and dihydrocitrinin, were identified from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Their structures were elucidated on the basis of comprehensive spectral analysis. All the new compounds were evaluated for their cytotoxic effects on four cell lines by the MTT method. Penicillenols A(1) and B(1) showed cytotoxicities against HL-60 cell line with IC(50) values of 0.76 microM and 3.20 microM, respectively.

Topics: Antifungal Agents; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fermentation; Humans; Magnetic Resonance Spectroscopy; Penicillium; Primulaceae; Pyrrolidinones; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles