tetramethylpyrazine has been researched along with endothelin-1 in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, Z; Pu, Z; Zeng, Z; Zhu, W; Zuo, W | 1 |
| Chen, X; Demura, H; Jin, Z; Liu, H; Naruse, M; Pan, J; Shi, Y; Zeng, Z; Zhou, X; Zhu, W | 1 |
| Cao, W; Demura, H; Luo, W; Naruse, M; Shi, Y; Zeng, Z; Zhu, YJ | 1 |
| Chen, S; Wang, L; Xu, Z | 1 |
| Li, Y; Shi, J; Sun, L; Wang, X | 1 |
| Lin, CL; Xu, YJ; Zhang, ZX | 1 |
| Bai, M; Jiang, AH; Ma, KL; Wang, QM; Wang, YJ | 1 |
| Bi, WF; Chang, NC; Chen, CH; Chen, JJ; Cheng, TH; Chiu, HC; Lian, WS; Lin, H; Liu, JC; Shih, CM; Wang, TC; Yang, HY | 1 |
| Chan, P; Chen, CH; Cheng, TH; Kao, PF; Lee, WS; Liu, JC; Yang, HY | 1 |
| Chen, DZ; Chen, SY; Gao, DF; Hao, GH; Niu, XL; Wang, WQ; Wei, J; Zhu, XL; Zhu, XX | 1 |
| Cheng, TH; Chou, YH; Hong, HJ; Wong, KL; Wu, KC; Wu, RS | 1 |
| Guo, RL; He, KW; Hu, YY | 1 |
| Feng, EZ; Huang, NX; Tian, ZX; Yang, SY; Yin, H; Zhang, Y | 1 |
| Fan, YX; Feng, GK; Jiang, J; Li, H; Ma, Z; Shi, W; Yang, X; Yin, YL | 1 |
| Deng, F; Fang, S; Zhang, B; Zhang, Y | 1 |
1 trial(s) available for tetramethylpyrazine and endothelin-1
| Article | Year |
|---|---|
Plasma endothelin-1 and nitric oxide correlate with ligustrazine alleviation of pulmonary artery hypertension in patients of chronic cor pulmonale from high altitude plateau during acute exacerbation.
Topics: Altitude; Blood Gas Analysis; Chronic Disease; Endothelin-1; Humans; Hypertension, Pulmonary; Nitric Oxide; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pyrazines; Respiration | 2014 |
14 other study(ies) available for tetramethylpyrazine and endothelin-1
| Article | Year |
|---|---|
[Effect of tetramethyl pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs].
Topics: Animals; Coronary Angiography; Coronary Vessels; Dogs; Endothelin-1; Heart Rate; Male; Myocardial Ischemia; Pyrazines; Vasoconstriction; Vasodilator Agents | 1996 |
Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals.
Topics: 6-Ketoprostaglandin F1 alpha; Angiography; Animals; Coronary Vessels; Dogs; Drugs, Chinese Herbal; Electrocardiography; Endothelin-1; Male; Pyrazines; Rabbits; Vasoconstriction; Vasodilator Agents | 1998 |
Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs.
Topics: Anesthesia, General; Animals; Blood Pressure; Dogs; Drugs, Chinese Herbal; Endothelin-1; Hemodynamics; Hypoxia; Lung Diseases; Pulmonary Alveoli; Pulmonary Circulation; Pyrazines; Vascular Resistance; Vasodilator Agents | 1998 |
[Effect of hypoxic hypercapnia on expression of endothelin-1 mRNA of pulmonary arterioles in rats].
Topics: Animals; Arterioles; Endothelin-1; Hypercapnia; Hypoxia; Male; Pulmonary Artery; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.
Topics: Animals; Disease Models, Animal; Endothelin-1; Free Radical Scavengers; Kidney; Kidney Diseases; Malondialdehyde; Pyrazines; Random Allocation; Rats; Rats, Wistar; Renal Artery; Reperfusion Injury; Superoxide Dismutase | 2002 |
[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].
Topics: Aged; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Nitrendipine; P-Selectin; Pulmonary Disease, Chronic Obstructive; Pyrazines; Thromboxane B2; Vasodilator Agents | 2001 |
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
Topics: Animals; Brain Ischemia; Endothelin-1; Female; Infarction, Middle Cerebral Artery; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelin-1; Endothelium, Vascular; Humans; Ligusticum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Pyrazines; Reactive Oxygen Species; Transcription Factor AP-1 | 2005 |
Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells.
Topics: Angiotensin II; Antioxidants; Blotting, Northern; Blotting, Western; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Down-Regulation; Endothelial Cells; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Phosphorylation; Promoter Regions, Genetic; Pyrazines; Reactive Oxygen Species; Recombinant Fusion Proteins; RNA, Messenger; Superoxides; Transfection | 2005 |
[Relationship between cardiomyocyte protein synthesis and cell viability].
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Endothelin-1; Myocytes, Cardiac; Protein Biosynthesis; Pyrazines; Rats; Rats, Sprague-Dawley | 2007 |
Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; DNA; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Male; Muscle, Smooth, Vascular; NADPH Oxidases; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Vasodilator Agents | 2007 |
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Cells, Cultured; Down-Regulation; Drugs, Chinese Herbal; E-Selectin; Endothelin-1; Endothelium, Vascular; Evodia; Humans; Interleukin-1alpha; Lipopolysaccharides; Morphinans; Proline; Pyrazines; Quinazolines; Quinolizines; Swine; Thromboxane B2 | 2012 |
Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cerebrovascular Circulation; Disease Models, Animal; Endothelin-1; Learning; Male; Memory; Pyrazines; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vasodilator Agents | 2015 |
Ligustrazine prevents basilar artery remodeling in two-kidney-two-clip renovascular hypertension rats via suppressing PI3K/Akt signaling.
Topics: Angiotensin II; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelin-1; Hypertension, Renovascular; Ligation; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pyrazines; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Temporal Arteries; Vascular Remodeling | 2020 |