Page last updated: 2024-09-04

tetrahydroharmine and harmine

tetrahydroharmine has been researched along with harmine in 12 studies

Compound Research Comparison

Studies
(tetrahydroharmine)
Trials
(tetrahydroharmine)
Recent Studies (post-2010)
(tetrahydroharmine)
Studies
(harmine)
Trials
(harmine)
Recent Studies (post-2010) (harmine)
20151,00111400

Protein Interaction Comparison

ProteinTaxonomytetrahydroharmine (IC50)harmine (IC50)
Chain A, Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.35
Glycogen synthase kinase-3 beta Sus scrofa (pig)10
[Tau protein] kinase Sus scrofa (pig)10
Dual specificity protein kinase CLK2Mus musculus (house mouse)0.28
Dual specificity protein kinase CLK4Mus musculus (house mouse)0.05
Dual specificity tyrosine-phosphorylation-regulated kinase 3Homo sapiens (human)0.604
Cyclin-T1Homo sapiens (human)0.72
Cyclin-A2Homo sapiens (human)10
Amine oxidase [flavin-containing] AHomo sapiens (human)0.0044
Dual specificity protein kinase CLK1Mus musculus (house mouse)0.072
Cyclin-dependent kinase 2Homo sapiens (human)10
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.072
Casein kinase I isoform deltaHomo sapiens (human)1.5
Casein kinase I isoform epsilonHomo sapiens (human)1.5
Dual specificity protein kinase CLK1Homo sapiens (human)0.086
Cyclin-dependent kinase 9Homo sapiens (human)0.72
Cyclin-dependent-like kinase 5 Homo sapiens (human)8
Aldehyde oxidaseHomo sapiens (human)0.03
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.0917
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)8
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)0.0397
Serine/threonine-protein kinase pim-3Homo sapiens (human)4.3
Serine/threonine-protein kinase haspinHomo sapiens (human)0.59
Dual specificity tyrosine-phosphorylation-regulated kinase 2Homo sapiens (human)1.3137
Dual specificity tyrosine-phosphorylation-regulated kinase 4Homo sapiens (human)9.5
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)5.08
Dual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiens (human)0.1183

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19901 (8.33)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's4 (33.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Dukat, M; Glennon, RA; Grella, B; Herrick-Davis, K; Khorana, N; Purohit, A; Smith, C; Teitler, M1
Issakainen, J; Liwszyc, GE; Rasanen, I; Vuori, E1
Ahmad, A; Begum, S; Faizi, S; Khan, KA; Siddiqui, BS; Siddiqui, S; Sultana, S1
Holmstedt, B1
Brito, GS; Callaway, JC; Grob, CS; Hearn, WL; Mash, DC; McKenna, DJ; Raymon, LP1
Callaway, JC1
Cruz, AP; Landeira-Fernandez, J; Motta, V; Santos, RG; Strassman, RJ1
Chaurasiya, ND; Joshi, VC; Khan, IA; Khan, SI; Miller, LS; Muhammad, I; Rahman, MM; Samoylenko, V; Tekwani, BL; Tripathi, LM; Wang, YH; Wigger, FT1
Alonso-Gil, S; de la Fuente Revenga, M; Feilding, A; Morales-García, JA; Perez-Castillo, A; Riba, J; Rodríguez-Franco, MI1
Costa, JL; Kummrow, F; Lanaro, R; Linardi, A; Maselli, BS; Umbuzeiro, GA1
Freitas, DP; Souza, RCZ; Sussulini, A; Tófoli, LFF; Zandonadi, FS1
Birk, L; Borges, GR; Eller, S; Grossi, P; Merib, JO; Oliveira, TF; Ossanes, DS; Scheid, C; Yonamine, M1

Trials

1 trial(s) available for tetrahydroharmine and harmine

ArticleYear
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members.
    Journal of ethnopharmacology, 2007, Jul-25, Volume: 112, Issue:3

    Topics: Adult; Anxiety; Banisteriopsis; Beverages; Brazil; Depressive Disorder; Double-Blind Method; Female; Fruit; Harmaline; Harmine; Humans; Male; Middle Aged; Molecular Structure; N,N-Dimethyltryptamine; Panic; Plant Extracts; Plant Leaves; Psychometrics; Religion; Surveys and Questionnaires; Treatment Outcome

2007

Other Studies

11 other study(ies) available for tetrahydroharmine and harmine

ArticleYear
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Animals; Binding, Competitive; Carbolines; Cell Line; Humans; Mice; Radioligand Assay; Rats; Receptors, Serotonin; Structure-Activity Relationship

2003
Daime--a ritual herbal potion.
    Journal of ethnopharmacology, 1992, Volume: 36, Issue:1

    Topics: Alkaloids; Gas Chromatography-Mass Spectrometry; Harmaline; Harmine; Indians, South American; N,N-Dimethyltryptamine; Plant Extracts; Plants, Medicinal; South America

1992
Study of the in vitro antimicrobial activity of harmine, harmaline and their derivatives.
    Journal of ethnopharmacology, 1992, Volume: 35, Issue:3

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Arthrodermataceae; Gram-Negative Bacteria; Gram-Positive Bacteria; Harmaline; Harmine; Microbial Sensitivity Tests

1992
Betacarbolines and tetrahydroisoquinolines: historical and ethnopharmacological background.
    Progress in clinical and biological research, 1982, Volume: 90

    Topics: Carbolines; Harmaline; Harmine; Indoles; Isoquinolines; Plants; Species Specificity; Structure-Activity Relationship; Tetrahydroisoquinolines

1982
Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: Administration, Oral; Beverages; Brazil; Calibration; Chromatography, Gas; Chromatography, High Pressure Liquid; Diphenhydramine; Harmaline; Harmine; Humans; Male; N,N-Dimethyltryptamine; Nitrogen; Phosphorus; Reference Standards; Reproducibility of Results

1996
Various alkaloid profiles in decoctions of Banisteriopsis caapi.
    Journal of psychoactive drugs, 2005, Volume: 37, Issue:2

    Topics: Alkaloids; Banisteriopsis; Harmaline; Harmine; Hydrogen-Ion Concentration; N,N-Dimethyltryptamine; Pharmaceutical Preparations; Plant Extracts; Plants; Time Factors

2005
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Alkaloids; Animals; Banisteriopsis; Beverages; Biflavonoids; Catechin; Ethnopharmacology; Harmaline; Harmine; Humans; Monoamine Oxidase; Neurodegenerative Diseases; Parkinson Disease; Plant Leaves; Plant Stems; Plants; Proanthocyanidins; Reference Standards; Superoxide Dismutase

2010
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro.
    Scientific reports, 2017, 07-13, Volume: 7, Issue:1

    Topics: Alkaloids; Animals; Banisteriopsis; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Harmaline; Harmine; Mice; Neural Stem Cells; Neurogenesis; Neuroprotective Agents

2017
Mutagenicity of Ayahuasca and Their Constituents to the Salmonella/Microsome Assay.
    Environmental and molecular mutagenesis, 2019, Volume: 60, Issue:3

    Topics: Banisteriopsis; Beverages; Harmine; Medicine, Traditional; Microsomes; Monoamine Oxidase; Mutagenicity Tests; Mutagens; N,N-Dimethyltryptamine; Plant Preparations; Psychotria; Salmonella

2019
Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Aug-15, Volume: 1124

    Topics: Banisteriopsis; Beverages; Brazil; Chromatography, High Pressure Liquid; Harmaline; Harmine; Mass Spectrometry; N,N-Dimethyltryptamine; Plant Preparations

2019
A rapid analytical strategy for the determination of ayahuasca alkaloids in non-ritualistic approaches by UHPLC-MS/MS.
    Forensic science international, 2020, Volume: 312

    Topics: Banisteriopsis; Beverages; Chromatography, High Pressure Liquid; Drug Trafficking; Hallucinogens; Harmaline; Harmine; Humans; Illicit Drugs; N,N-Dimethyltryptamine; Tandem Mass Spectrometry

2020