Page last updated: 2024-08-26

tetrahydrodeoxycorticosterone and pregnenolone

tetrahydrodeoxycorticosterone has been researched along with pregnenolone in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (38.71)18.2507
2000's14 (45.16)29.6817
2010's4 (12.90)24.3611
2020's1 (3.23)2.80

Authors

AuthorsStudies
Dawson, M; Fairweather, EE; Hamilton, NM; Hamilton, NS; Hitchin, JR; James, DI; Jones, SD; Jordan, AM; Lyons, AJ; Ogilvie, DJ; Small, HF; Thomson, GJ; Waddell, ID1
Bowers, BJ; Wehner, JM1
Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH1
Matsumoto, K; Ojima, K; Watanabe, H1
Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL1
Krueger, KE; Vicini, S; Wang, JF; Zhu, WJ1
Barbaccia, ML; Biggio, G; Concas, A; Mostallino, MC; Perra, C; Purdy, RH; Roscetti, G; Trabucchi, M1
Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K1
Chapell, R; Leidenheimer, NJ1
Bender, AS; Norenberg, MD1
Holsboer, F; Rupprecht, R1
Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H1
Biggio, G; Carotti, A; Franco, M; Latrofa, A; Liso, G; Ricciardi, L; Sanna, E; Serra, M; Trapani, G1
Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J1
Barbosa, AD; Morato, GS2
Homanics, GE; Huguenard, JR; Huntsman, MM; Mihalek, RM; Porcello, DM1
Bellodi, L; Biggio, G; Bogdanovich-Djukic, V; Brambilla, F; Perna, G; Pisu, MG; Purdy, RH; Serra, M1
Alomary, AA; Fitzgerald, RL; Koob, GF; O'Dell, LE; Purdy, RH; Vallée, M1
Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A1
Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G1
Bäckström, T; Johansson, IM; Lindblad, C; Rahman, M; Wang, MD1
Bradford, DW; Butterfield, MI; Grobin, AC; Khisti, RT; Lieberman, JA; Madison, RD; Marx, CE; Massing, MW; Morrow, AL; Shampine, LJ; Trost, WT1
Hamann, M; Richter, A; Richter, F1
Biggio, G; Concas, A; Marotto, MF; Marra, C; Marrosu, F; Melis, GB; Orrù, M; Paoletti, AM; Sogliano, C; Tuveri, A; Zedda, P1
Ahboucha, S; Baker, GB; Butterworth, RF; Chatauret, N; Jiang, W; Mamer, O1
Alward, SE; de Wit, H; Grant, KA; Leslie Morrow, A; O'Buckley, TK; Porcu, P; Song, SC1
Baker, C; Bamber, BA; Sturt, BL1
Caley, A; Gielen, MC; Harvey, RJ; Smart, TG; Wilkins, ME1
Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y1

Reviews

2 review(s) available for tetrahydrodeoxycorticosterone and pregnenolone

ArticleYear
Neuroactive steroid modulators of the stress response.
    Annals of the New York Academy of Sciences, 1995, Dec-29, Volume: 771

    Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological

1995
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
    Trends in neurosciences, 1999, Volume: 22, Issue:9

    Topics: Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Humans; Neuroprotective Agents; Neurosecretory Systems; Pregnanolone; Pregnenolone; Progesterone; Steroids

1999

Other Studies

29 other study(ies) available for tetrahydrodeoxycorticosterone and pregnenolone

ArticleYear
Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
    Journal of medicinal chemistry, 2012, May-10, Volume: 55, Issue:9

    Topics: Antineoplastic Agents; Cell Survival; Enzyme Inhibitors; Glucosephosphate Dehydrogenase; HEK293 Cells; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pregnanes; Structure-Activity Relationship

2012
Biochemical and behavioral effects of steroids on GABAA receptor function in long- and short-sleep mice.
    Brain research bulletin, 1992, Volume: 29, Issue:1

    Topics: Anesthetics; Animals; Behavior, Animal; Brain Chemistry; Chlorides; Desoxycorticosterone; Ethanol; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Pentobarbital; Pregnanediones; Pregnenolone; Receptors, GABA-A; Sleep; Species Specificity; Steroids

1992
Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice.
    Brain research, 1996, Feb-05, Volume: 708, Issue:1-2

    Topics: Adrenalectomy; Allosteric Regulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Corticotropin-Releasing Hormone; Desoxycorticosterone; GABA-A Receptor Antagonists; Male; Methoxamine; Mice; Mice, Inbred Strains; Pentobarbital; Pregnenolone; Receptors, GABA-A; Sleep; Social Behavior; Social Isolation; Stress, Psychological; Yohimbine

1996
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
    European journal of pharmacology, 1996, May-23, Volume: 304, Issue:1-3

    Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids

1996
Delta subunit inhibits neurosteroid modulation of GABAA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Nov-01, Volume: 16, Issue:21

    Topics: Allosteric Regulation; Anesthetics; Animals; Cells, Cultured; Cerebellum; Chlorides; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Agonists; Gene Expression Regulation, Developmental; Ion Channel Gating; Membrane Potentials; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection

1996
Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain.
    Neuropharmacology, 1996, Volume: 35, Issue:9-10

    Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Carbolines; Desoxycorticosterone; Electroshock; GABA Antagonists; GABA-A Receptor Antagonists; Isoniazid; Male; Neurotransmitter Agents; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Steroids

1996
Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids.
    Life sciences, 1997, Volume: 61, Issue:4

    Topics: Animals; Corticotropin-Releasing Hormone; Desoxycorticosterone; Dose-Response Relationship, Drug; Ginsenosides; Hormone Antagonists; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Peptide Fragments; Pregnenolone; Receptors, GABA-A; Saponins; Sleep; Social Isolation; Stress, Physiological

1997
Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.
    Brain research. Molecular brain research, 1997, Dec-15, Volume: 52, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Chloride Channels; Desoxycorticosterone; Enzyme Activation; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Phorbol Esters; Pregnenolone; Protein Kinase C; Receptors, GABA-A; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis

1997
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation

1998
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 63, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids

1999
Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies.
    Journal of medicinal chemistry, 1999, Sep-23, Volume: 42, Issue:19

    Topics: Animals; Cloning, Molecular; Desoxycorticosterone; Female; Humans; Imidazoles; Isoquinolines; Ligands; Male; Oocytes; Pregnenolone; Progesterone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Xenopus

1999
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
    Journal of neurochemistry, 2000, Volume: 75, Issue:2

    Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis

2000
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids

2000
Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol.
    Brain research bulletin, 2002, Volume: 58, Issue:1

    Topics: Alcoholism; Animals; Body Temperature; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Pregnenolone

2002
Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.
    Journal of neurophysiology, 2003, Volume: 89, Issue:3

    Topics: Anesthetics; Animals; Desoxycorticosterone; Evoked Potentials; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neural Pathways; Pregnenolone; Receptors, GABA-A; Synapses; Thalamus

2003
Neurosteroid secretion in panic disorder.
    Psychiatry research, 2003, May-30, Volume: 118, Issue:2

    Topics: Adult; Analysis of Variance; Case-Control Studies; Dehydroepiandrosterone; Desoxycorticosterone; Female; Humans; Panic Disorder; Pregnenolone; Progesterone

2003
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
    European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3

    Topics: Adrenalectomy; Animals; Brain; Desoxycorticosterone; Ethanol; Male; Orchiectomy; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids

2004
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
    Neuropsychobiology, 2004, Volume: 50, Issue:1

    Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values

2004
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
    Neurochemistry international, 2006, Volume: 49, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards

2006
Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: Androstane-3,17-diol; Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediol; Pregnanes; Pregnenolone; Protein Subunits; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Steroids; Xenopus laevis; Zolpidem

2006
Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:4

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Olanzapine; Pregnanolone; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors

2006
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
    Hormones and behavior, 2007, Volume: 52, Issue:2

    Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone

2007
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2007, Volume: 29, Issue:4

    Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone

2007
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
    Epilepsia, 2008, Volume: 49, Issue:7

    Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroencephalography; Epilepsy; Estradiol; Female; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Premenstrual Syndrome; Progesterone; Receptors, GABA

2008
Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.
    Neurogastroenterology and motility, 2008, Volume: 20, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Brain Chemistry; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Indomethacin; Male; Molecular Structure; Motor Activity; Portacaval Shunt, Surgical; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids

2008
Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
    Alcoholism, clinical and experimental research, 2010, Mar-01, Volume: 34, Issue:3

    Topics: Adult; Androstane-3,17-diol; Androsterone; Animals; Central Nervous System Depressants; Desoxycorticosterone; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Young Adult

2010
Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.
    Neuroscience letters, 2010, Apr-12, Volume: 473, Issue:3

    Topics: Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans Proteins; Desoxycorticosterone; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Ion Channel Gating; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Pregnenolone; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A

2010
Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.
    The Journal of physiology, 2016, 07-01, Volume: 594, Issue:13

    Topics: Desoxycorticosterone; Glycine; HEK293 Cells; Humans; Hyperekplexia; Models, Molecular; Mutation, Missense; Picrotoxin; Pregnenolone; Receptors, Glycine; Zinc

2016
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
    Psychoneuroendocrinology, 2020, Volume: 121

    Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry

2020