tetrahydrodeoxycorticosterone has been researched along with desoxycorticosterone in 256 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (15.63) | 18.7374 |
| 1990's | 75 (29.30) | 18.2507 |
| 2000's | 100 (39.06) | 29.6817 |
| 2010's | 39 (15.23) | 24.3611 |
| 2020's | 2 (0.78) | 2.80 |
| Authors | Studies |
|---|---|
| Bokkenheuser, VD; Dehazya, P; Kelly, WG; Winter, J | 1 |
| Bokkenheuser, VD; de Leon, O; Dehazya, P; Kelly, WG; Winter, J | 1 |
| Honour, JW; Schneider, MA | 1 |
| Bowers, BJ; Wehner, JM | 1 |
| Coirini, H; De Nicola, AF; Ferrini, M; González Deniselle, MC; González, SL | 1 |
| Moore, PH; Morrow, AL; Paul, SM; Purdy, RH | 2 |
| Nemeroff, CB; Owens, MJ; Ritchie, JC | 1 |
| Deutch, AY; Grobin, AC; Roth, RH | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Gee, KW; Lan, NC | 1 |
| Gee, KW; Lan, NC; Mirasedeghi, S; Wieland, S | 1 |
| Morrow, AL; Pace, JR; Paul, SM; Purdy, RH | 1 |
| Blakeman, DP; Im, WB | 1 |
| Hales, TG; Lambert, JJ; Peters, JA; Sturgess, NC | 1 |
| Majewska, MD | 1 |
| Ayer, DE; Blakeman, DP; Davis, JP; Im, WB | 1 |
| Blinn, JR; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Costa, E; Paul, SM; Pritchett, DB; Puia, G; Purdy, RH; Santi, MR; Seeburg, PH; Vicini, S | 1 |
| Barker, JL; Harrison, NL; Majewska, MD; Paul, SM; Schwartz, RD | 1 |
| Bournot, P; Ramirez, LC | 1 |
| Crawley, JN; Glowa, JR; Majewska, MD; Paul, SM | 1 |
| Majewska, MD; Martin, JV; Mendelson, WB; Paul, SM; Perlis, M; Wagner, R | 1 |
| Kavaliers, M | 1 |
| Ehlers, ME; Griffing, GT; Melby, JC; Wilson, TE | 1 |
| Gawienowski, AM; Kessler, LJ; Tan, BS; Yin, CM | 1 |
| Andrews, AW; Ayengar, NK; Bokkenheuser, VD; Lebherz, WB; McSherry, CK; Mosbach, EH; Mosenthal, AC; Pienta, RJ; Wallenstein, S; Winter, J | 1 |
| Casey, ML; MacDonald, PC | 1 |
| Dubrovsky, B; Kraulis, I; Williams, D | 1 |
| MacDonald, PC; Parker, CR; Simpson, ER; Winkel, CA | 1 |
| Holsboer, F; Teschemacher, A; Zeise, ML; Zieglgänsberger, W | 1 |
| Fukuda, H; Ito, Y; Segawa, K | 1 |
| Jussofie, A; Kalff, R; Reinhardt, V | 1 |
| Ator, NA; Grant, KA; Griffiths, RR; Paul, SM; Purdy, RH | 1 |
| Deutsch, SI; Hitri, A; Park, CH | 1 |
| Auta, J; Costa, E; Guidotti, A; Kozikowski, A; Ma, D; Romeo, E | 1 |
| Jussofie, A | 3 |
| Ho, IK; Ito, Y | 1 |
| Crawley, JN; Drugan, RC; Paul, SM | 1 |
| Deutsch, SI; Mastropaolo, J | 1 |
| DeBold, JF; Frye, CA | 1 |
| Inglefield, JR; Kellogg, CK; Pleger, GL; Taylor, MK | 1 |
| Finn, DA; Gee, KW | 1 |
| Damm, K; Holsboer, F; Reul, JM; Rupprecht, R; Trapp, T; van Steensel, B; Wetzel, C; Zieglgänsberger, W | 1 |
| Bertz, RJ; Kroboth, PD; Reynolds, IJ | 1 |
| André, M; Arancibia, S; Belmar, J; Tapia-Arancibia, L | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Matsumoto, K; Ojima, K; Watanabe, H | 1 |
| Devaud, LL; Finn, DA; Morrow, AL; Purdy, RH | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Krueger, KE; Vicini, S; Wang, JF; Zhu, WJ | 1 |
| Duncan, JE; Frye, CA | 1 |
| Fiszer de Plazas, S; Gravielle, MC; Pignataro, L | 1 |
| Gavish, M; Peter, Y; Pick, CG; Terkel, J; Weizman, R | 1 |
| Zimmerberg, B | 1 |
| Biglieri, EG | 1 |
| Barbaccia, ML; Biggio, G; Concas, A; Mostallino, MC; Perra, C; Purdy, RH; Roscetti, G; Trabucchi, M | 1 |
| Acosta-Burruel, M; Alauddin, M; Bolger, MB; Gee, KW; Hawkinson, JE; Hogenkamp, DJ; Kimbrough, CL; Lan, NC; Tahir, SH; Upasani, RB; Whittemore, ER; Woodward, RM | 1 |
| Almeida, OF; Holsboer, F; Koranyi, L; Montkowski, A; Patchev, VK; Rouskova, D | 1 |
| Biscardi, R; Wilson, MA | 1 |
| Vicini, S; Zhu, WJ | 1 |
| Gee, KW; Lan, NC; Park, CH; Whittemore, ER; Woodward, RM; Xue, BG | 1 |
| Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Reith, CA; Sillar, KT | 1 |
| Johnson, NJ; Rodgers, RJ | 1 |
| Chapell, R; Leidenheimer, NJ | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Devaud, LL; Fritschy, JM; Morrow, AL | 1 |
| Alvarez-Hernandez, X; Bueno, OF; Leidenheimer, NJ; Robinson, LC | 1 |
| Burg, M; Heinemann, U; Schmitz, D | 1 |
| Barbaccia, ML; Biggio, G; Concas, A; Follesa, P; Grisenti, P; Mostallino, MC; Porcu, P; Purdy, RH; Trabucchi, M | 1 |
| Banerjee, PK; Brailowsky, S; Olsen, RW; Snead, OC; Tillakaratne, NJ; Tobin, AJ | 1 |
| Banerjee, PK; Snead, OC | 1 |
| Banerjee, PK; Liu, CC; Snead, OC | 1 |
| Bender, AS; Norenberg, MD | 1 |
| di Michele, F; Hermann, B; Holsboer, F; Pasini, A; Romeo, E; Rupprecht, R; Spalletta, G; Ströhle, A | 1 |
| Deisz, RA; Holsboer, F; Vedder, H; Wetzel, CH; Zieglgänsberger, W | 1 |
| Holsboer, F; Rupprecht, R | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Amin, J; Moorefield, CN; Morris, KD | 1 |
| Biggio, G; Carotti, A; Franco, M; Latrofa, A; Liso, G; Ricciardi, L; Sanna, E; Serra, M; Trapani, G | 1 |
| Breese, GR; Criswell, HE; McCown, TJ; Ming, Z; Mueller, RA | 1 |
| Cooper, EJ; Edwards, FA; Johnston, GA | 1 |
| Affricano, D; Agabio, R; Barbaccia, ML; Colombo, G; Gessa, GL; Purdy, RH; Trabucchi, M | 1 |
| Felbinger, TW; Jacob, K; Röll, W; Vogeser, M | 1 |
| Grant, KA; Janak, PH; Janis, GC; Matthews, DB; Morrow, AL; Samson, HH; VanDoren, MJ | 1 |
| Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Carroll, SS; Li, YH; McEwen, BS; Orchinik, M; Weiland, NG | 1 |
| Frye, CA; Petralia, SM; Rhodes, ME | 1 |
| Hevers, W; Korpi, ER; Lüddens, H | 1 |
| Bozzini, CE; Fiszer de Plazas, S; Mitridate de Novara, AM; Viapiano, MS | 1 |
| Reddy, DS; Rogawski, MA | 2 |
| Grobin, AC; Matthews, DB; Montoya, D; Morrow, AL; Swartzwelder, HS; Wilson, WA | 1 |
| Affricano, D; Barbaccia, ML; Biggio, G; Maciocco, E; Purdy, RH; Spiga, F | 1 |
| Barbaccia, ML; Biggio, G; Purdy, RH; Serra, M | 1 |
| Biggio, G; Eva, C; Ferrara, G; Panzica, GC; Pisu, MG; Serra, M; Zammaretti, F | 1 |
| Grobin, AC; Morrow, AL | 1 |
| Bianchi, MT; Macdonald, RL; Wohlfarth, KM | 1 |
| Lancel, M; Müller-Preuss, P; Rupprecht, R | 1 |
| Affricano, D; Barbaccia, ML; Carai, MA; Colombo, G; Gessa, GL; Melis, S; Purdy, RH; Vacca, G | 1 |
| Gambhir, M; Mediratta, PK; Ray, M; Sharma, KK | 1 |
| Biggio, G; Dazzi, L; Pisu, MG; Reho, A; Seu, E; Trapani, G | 1 |
| Biggio, G; Dazzi, L; Pisul, MG; Purdy, RH; Serra, M | 1 |
| Barbosa, AD; Morato, GS | 2 |
| Fernandez, G; Pappalardo, A; Peluso, JJ; White, BA | 1 |
| Biggio, G; Eva, C; Oberto, A; Pisu, MG; Serra, M | 1 |
| Bianchi, MT; Haas, KF; Macdonald, RL | 1 |
| Homanics, GE; Losi, G; Vicini, S | 1 |
| Reddy, DS | 2 |
| Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M | 1 |
| Homanics, GE; Huguenard, JR; Huntsman, MM; Mihalek, RM; Porcello, DM | 1 |
| Bellodi, L; Biggio, G; Bogdanovich-Djukic, V; Brambilla, F; Perna, G; Pisu, MG; Purdy, RH; Serra, M | 1 |
| Frye, C; Seliga, A | 1 |
| Almeida, OF; Darwish, M; Holsboer, F; Mitev, YA; Patchev, VK; Wolf, SS | 1 |
| ENGELHARDT, A; GREEFF, K; HOLTZ, P; SCHUMANN, HJ | 1 |
| EVERSOLE, WJ; GIERE, FA; ROCK, MH | 1 |
| EVERSOLE, WJ; GIERE, FA | 1 |
| GIERE, FA | 1 |
| BRADLEY, SE; NICKEL, JF; PAPPER, EM; SMYTHE, CM | 1 |
| GERARD, RW; OCHS, S; SIGG, E | 1 |
| GORDON, M; RAPELA, CE | 1 |
| HINTON, JW; PFEFFER, RB | 1 |
| KUSCHINSKY, G; TRENDELENBURG, U; VORHERR, H | 1 |
| BIRKE, G; DUNER, H; PLANTIN, LO; VON EULER, US | 1 |
| GELLHORN, E; REDGATE, ES | 2 |
| EADE, NR | 1 |
| KLEIN, U; KRACHT, J | 1 |
| Cier, JF; Klepping, J; Paulet, G | 1 |
| BIANCHI, M; FREDENUCCI, R; MALMEJAC, C; MALMEJAC, J; NEVERRE, G | 1 |
| GERSHONCOHEN, J; GRIFFITH, JQ; GRIFFITH, MG; HERMEL, MB | 1 |
| ROSS, EJ | 1 |
| MIRKIN, BL | 1 |
| BRUNSON, JG; EVERS, CG; HINTON, WE | 1 |
| BLAKE, WD | 1 |
| OESTER, YT | 1 |
| JAYLE, MF; PASQUALINI, JR | 1 |
| Brickley, SG; Farrant, M; Mody, I; Stell, BM; Tang, CY | 1 |
| Bianchi, MT; Macdonald, RL | 1 |
| Alomary, AA; Fitzgerald, RL; Koob, GF; O'Dell, LE; Purdy, RH; Vallée, M | 1 |
| EVERSOLE, WJ; HORRES, AD; ROCK, M | 1 |
| DUNCAN, LE; NICHOLS, MP; ROSENBERG, E; SOLOMON, DH | 1 |
| BRUCKE, F; KAINDL, F; MAYER, H | 1 |
| VOGT, M | 1 |
| Frye, CA; Petralia, SM; Rhodes, ME; Stein, B | 1 |
| Biggio, G; Concas, A; Fratta, S; Lello, S; Melis, GB; Orrù, M; Paoletti, AM; Ranuzzi, F; Sogliano, C | 1 |
| Minami, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N | 1 |
| Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A | 1 |
| Biggio, G; Fabrazzo, M; Maj, M; Monteleone, P; Pisu, MG; Serra, M; Tortorella, A | 1 |
| Kaufman, S; Storey, E | 1 |
| Dubrovsky, B; Harris, J; Tatarinov-Levin, A | 1 |
| Houser, CR; Huang, CS; Mody, I; Peng, Z; Stell, BM | 1 |
| Baghai, TC; di Michele, F; Eser, D; Pasini, A; Romeo, E; Rupprecht, R; Schüle, C; Zwanzger, P | 1 |
| Frye, CA; Petralia, SM | 1 |
| He, XY; Pullarkat, R; Schulz, H; Wegiel, J; Yang, SY; Yang, YZ | 1 |
| Bernardi, G; Bonaviri, G; Caltagirone, C; di Michele, F; Romeo, E; Spalletta, G | 1 |
| Frye, CA; Rhodes, ME | 2 |
| Bäckström, T; Lundgren, P; Strömberg, J | 1 |
| Bíró, T; Maksay, G | 1 |
| Gavrilovici, C; McIntyre, DC; Poulter, MO; Schwabe, K | 1 |
| Boyd, KN; Khisti, RT; Kumar, S; Morrow, AL | 1 |
| Alciati, A; Biggio, G; Brambilla, F; Mellado, C; Perini, G; Pisu, MG; Purdy, RH; Serra, M; Zanone, S | 1 |
| Haugvicová, R; Kasal, A; Mares, P | 1 |
| Belelli, D; Borghese, CM; Ebert, B; Harris, RA; Herd, MB; Lambert, JJ; Marshall, G; Stórustovu, Sí; Wafford, KA | 1 |
| Mares, P | 1 |
| Burnham, WM; Edwards, HE; Vimal, S | 1 |
| Biggio, G; Concas, A; Contu, R; Lello, S; Marotto, MF; Melis, GB; Orrù, MM; Paoletti, AM; Romagnino, S; Zedda, P | 1 |
| Frye, CA; Lydon, JP; O'Malley, BW; Pfaff, DW; Sumida, K | 1 |
| Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G | 1 |
| Frye, CA; Petralia, SM; Walf, AA | 1 |
| Biggio, G; Carta, MG; Contu, P; Hardoy, MC; Pisu, MG; Serra, M | 1 |
| Biggio, F; Caria, S; Follesa, P; Gorini, G; Mostallino, MC; Murru, L; Sanna, E | 1 |
| Andersson, A; Asztely, F; Heeroma, JH; McEvoy, AW; Rydenhag, B; Scimemi, A; Strandberg, J; Thom, M; Walker, MC | 1 |
| Bäckström, T; Johansson, IM; Lindblad, C; Rahman, M; Wang, MD | 1 |
| Mashimo, T; Takahashi, A; Uchida, I | 1 |
| Agís-Balboa, RC; Costa, E; Guidotti, A; Maloku, E; Pinna, G; Veldic, M; Zhubi, A | 1 |
| D'Alfonso, S; Dann, M; Gavrilovici, C; Poulter, MO | 1 |
| Bradford, DW; Butterfield, MI; Grobin, AC; Khisti, RT; Lieberman, JA; Madison, RD; Marx, CE; Massing, MW; Morrow, AL; Shampine, LJ; Trost, WT | 1 |
| Fukuda, A; Furukawa, T; Ueno, S; Yamada, J; Yamamoto, S | 1 |
| Barrett-Jolley, R; Pyner, S; Womack, MD | 1 |
| da Silva, HM; Hosie, AM; Smart, TG; Wilkins, ME | 1 |
| McIntyre, DC; Poulter, MO; Schwabe, K | 1 |
| Maguire, J; Mody, I | 1 |
| Amin, J; Hadley, SH | 1 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Dieni, C; Dutia, MB; Frondaroli, A; Grassi, S; Pettorossi, VE | 1 |
| Houser, CR; Mody, I; Wei, W; Zhang, N | 1 |
| Belelli, D; Dempster, J; Gentet, LJ; Mitchell, EA | 1 |
| Poisbeau, P; Schlichter, R; Vergnano, AM | 1 |
| Ahboucha, S; Butterworth, RF | 1 |
| Sedelnikova, A; Weiss, DS; Zheleznova, N | 1 |
| Biggio, G; Concas, A; Marotto, MF; Marra, C; Marrosu, F; Melis, GB; Orrù, M; Paoletti, AM; Sogliano, C; Tuveri, A; Zedda, P | 1 |
| Dósa, Z; Drasbek, KR; Jensen, K; Vardya, I | 1 |
| Ahboucha, S; Baker, GB; Butterworth, RF; Chatauret, N; Jiang, W; Mamer, O | 1 |
| Han, SM; Youn, DH | 1 |
| Frye, CA; Paris, JJ; Rhodes, ME | 2 |
| De Sarro, G; Dore, R; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Russo, E; Serra, M | 1 |
| Frye, CA; Walf, AA | 1 |
| Clarke, L; da Silva, H; Hosie, AM; Smart, TG | 1 |
| Meera, P; Olsen, RW; Otis, TS; Wallner, M | 1 |
| Deuchars, J; Deuchars, SA; Spary, E; Wang, L | 1 |
| Baur, R; Kaur, KH; Sigel, E | 2 |
| Kondo, D; Kurihara, T; Saegusa, H; Takasaki, I; Tanabe, T; Yabe, R; Zong, S | 1 |
| Codocedo, JF; Huidobro-Toro, JP; Rodríguez, FE | 1 |
| Baghai, TC; di Michele, F; Eser, D; Padberg, F; Pasini, A; Romeo, E; Rupprecht, R; Zwanzger, P | 1 |
| Frye, CA; Paris, JJ | 1 |
| Biggio, G; Morgan, ML; Pisu, MG; Rapkin, AJ; Rasgon, N; Serra, M | 1 |
| Alward, SE; de Wit, H; Grant, KA; Leslie Morrow, A; O'Buckley, TK; Porcu, P; Song, SC | 1 |
| Bayliss, DA; Chen, X; Kapur, J; Schwartz, LC; Shu, S; Sun, C | 1 |
| Baker, C; Bamber, BA; Sturt, BL | 1 |
| Baghai, TC; di Michele, F; Eser, D; Pasini, A; Romeo, E; Rupprecht, R; Schüle, C | 1 |
| Chang, JL; Chen, MJ; Lin, TB; Lu, HT; Pan, SF; Peng, HY; Wu, HC | 1 |
| Frye, CA; Koonce, CJ; Walf, AA | 1 |
| Frye, CA; Paris, JJ; Walf, AA | 1 |
| Hess, GP; Ramakrishnan, L | 1 |
| Fodor, L; Maksay, G | 1 |
| Ferguson, SS; Gavrilovici, C; Kia, A; Nelson, R; Poulter, MO; Ribeiro, F | 1 |
| Barbaccia, ML; Bortolato, M; Cuomo, V; Devoto, P; Flore, G; Frau, R; Marrosu, F; Pisanu, S; Pistritto, G; Ristaldi, MS; Roncada, P; Saba, P; Soggiu, A; Tattoli, M; Zappala, A | 1 |
| Bonin, RP; De Koninck, Y; Eng, DG; Labrakakis, C; Orser, BA; Whissell, PD | 1 |
| Cho, CH; Han, SK; Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Lee, SK; Lee, SY; Pandit, S; Park, JB; Ryu, PD; Stern, JE | 1 |
| MacKenzie, G; Maguire, J; Moss, SJ; Sarkar, J; Wakefield, S | 1 |
| Connell, JM; Dargie, HG; Fraser, R; Freel, EM; Jardine, AG; Mark, PB; McQuarrie, EP; Patel, RK | 1 |
| Cho, KH; Jang, HJ; Kim, MJ; Rhie, DJ; Yoon, SH | 1 |
| Carver, CM; Reddy, DS | 1 |
| Avoli, M; Herrington, R; Lévesque, M | 2 |
| Akk, G; Covey, DF; Eaton, MM; Lim, YB | 1 |
| Marowsky, A; Vogt, KE | 1 |
| Eyre, MD; Kerti-Szigeti, K; Nusser, Z | 1 |
| Adams, JM; Smart, TG; Thomas, P | 1 |
| Behr, J; Çalışkan, G; Gerevich, Z; Gruber, D; Heinemann, U; Schulz, SB | 1 |
| Anton, F; Darbon, P; Hanesch, U; Juif, PÉ; Poisbeau, P; Zell, V | 1 |
| Avoli, M; Herrington, R; Lévesque, M; Shiri, Z | 1 |
| Smart, TG; Villumsen, IS; Wellendorph, P | 1 |
| Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD | 1 |
| Agusti, A; Bäckström, T; Doverskog, M; Felipo, V; Johansson, M; Llansola, M; Malinina, E; Montoliu, C; Ragagnin, G; Strömberg, J | 1 |
| Ahmadiani, A; Dargahi, L; Ghasemi, R; Haeri, A; Rahmani, B | 1 |
| Bäckström, T; Doverskog, M; Johansson, M; Ragagnin, G; Strömberg, J | 1 |
| Butterworth, RF | 1 |
| Boychuk, JA; Butler, CR; Halmos, KC; Smith, BN | 1 |
| Caley, A; Gielen, MC; Harvey, RJ; Smart, TG; Wilkins, ME | 1 |
| Baur, R; Sigel, E; Wongsamitkul, N | 1 |
| Akk, G; Bracamontes, JR; Budelier, MM; Chen, ZW; Cheng, WWL; Covey, DF; Evers, AS; Jiang, X; Krishnan, K; Shin, DJ; Wang, C | 1 |
| Endres, T; Lessmann, V; Meis, S; Munsch, T | 1 |
| Bayramov, R; Filiz, AK; Karabulut, S; Korkmaz Bayramov, K; Ozdemir, E; Taskiran, AS | 1 |
| Akk, G; Burbridge, AB; Evers, AS; Germann, AL; Pierce, SR; Reichert, DE; Steinbach, JH | 1 |
| Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y | 1 |
11 review(s) available for tetrahydrodeoxycorticosterone and desoxycorticosterone
| Article | Year |
|---|---|
Steroid regulation of the GABAA receptor: ligand binding, chloride transport and behaviour.
Topics: Animals; Biological Transport; Central Nervous System; Chlorides; Desoxycorticosterone; Ligands; Mice; Pregnanolone; Rats; Receptors, GABA-A; Steroids | 1990 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Topics: Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Humans; Neuroprotective Agents; Neurosecretory Systems; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1999 |
Stress and neuroactive steroids.
Topics: Animals; Brain Chemistry; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Stress, Physiological | 2001 |
The clinical potentials of endogenous neurosteroids.
Topics: Animals; Brain; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Seizures; Stress, Psychological | 2002 |
Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
Topics: Animals; Anti-Anxiety Agents; Brain; Desoxycorticosterone; GABA-A Receptor Antagonists; Humans; Stress, Physiological | 2003 |
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Manganese; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 2007 |
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.
Topics: Allosteric Regulation; Androstane-3,17-diol; Animals; Brain; Desoxycorticosterone; Humans; Nerve Net; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A | 2013 |
Neurosteroids; potential underpinning roles in maintaining homeostasis.
Topics: Brain; Desoxycorticosterone; Homeostasis; Humans; Hypothalamo-Hypophyseal System; Neurotransmitter Agents; Pituitary-Adrenal System; Pregnanolone; Synaptic Transmission | 2016 |
GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo.
Topics: Animals; Desoxycorticosterone; Evoked Potentials; GABA-A Receptor Antagonists; Humans; Learning; Memory; Pregnanolone; Receptors, GABA-A; Saccades | 2016 |
Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities.
Topics: Animals; Brain; Desoxycorticosterone; Drug Discovery; Hepatic Encephalopathy; Humans; Liver; Molecular Targeted Therapy; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A | 2016 |
5 trial(s) available for tetrahydrodeoxycorticosterone and desoxycorticosterone
| Article | Year |
|---|---|
Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol.
Topics: Adult; Androstenes; Anxiety; Contraceptives, Oral, Combined; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Follicular Phase; Humans; Luteal Phase; Phobic Disorders; Pregnanolone; Progesterone; Psychometrics | 2004 |
Observational study on the stability of the psychological status during normal pregnancy and increased blood levels of neuroactive steroids with GABA-A receptor agonist activity.
Topics: Adult; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Female; Follow-Up Studies; GABA-A Receptor Agonists; Humans; Hydrocortisone; Menstrual Cycle; Neuropsychological Tests; Pregnancy; Pregnanes; Pregnanolone; Progesterone; Prospective Studies; Psychiatric Status Rating Scales; Psychometrics; Receptors, GABA-A; Reference Values; Stress, Psychological | 2006 |
Changes in CCK-4 induced panic after treatment with the GABA-reuptake inhibitor tiagabine are associated with an increase in 3alpha,5alpha-tetrahydrodeoxycorticosterone concentrations.
Topics: Adult; Desoxycorticosterone; Female; GABA Uptake Inhibitors; Humans; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Panic Disorder; Pilot Projects; Tetragastrin; Tiagabine | 2009 |
Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women.
Topics: Brain; Dehydroepiandrosterone; Depressive Disorder, Major; Desoxycorticosterone; Estrogens; Female; Humans; Middle Aged; Postmenopause; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Sertraline | 2010 |
Mirtazapine does not influence tetrahydrodeoxycorticosterone levels in depressed patients.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desoxycorticosterone; Female; Humans; Hypothalamo-Hypophyseal System; Male; Mianserin; Middle Aged; Mirtazapine; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult | 2010 |
240 other study(ies) available for tetrahydrodeoxycorticosterone and desoxycorticosterone
| Article | Year |
|---|---|
Isolation and characterization of human fecal bacteria capable of 21-dehydroxylating corticoids.
Topics: Anaerobiosis; Anti-Bacterial Agents; Desoxycorticosterone; Eubacterium; Feces; Humans; Pregnanediol; Steroid 21-Hydroxylase | 1977 |
Formation and metabolism of tetrahydrodeoxycorticosterone by human fecal flora.
Topics: Bacteria; Desoxycorticosterone; Feces; Humans; Kinetics; Lactobacillus; Pregnanediol; Pregnanolone | 1976 |
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Topics: Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Adult; Carcinoma; Child; Contraceptives, Oral; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Luteal Phase; Male; Middle Aged; Mineralocorticoids; Progesterone | 1992 |
Biochemical and behavioral effects of steroids on GABAA receptor function in long- and short-sleep mice.
Topics: Anesthetics; Animals; Behavior, Animal; Brain Chemistry; Chlorides; Desoxycorticosterone; Ethanol; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Pentobarbital; Pregnanediones; Pregnenolone; Receptors, GABA-A; Sleep; Species Specificity; Steroids | 1992 |
Regulation of flunitrazepam binding in the dorsal horn of the spinal cord by adrenalectomy and corticosteroids.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Corticosterone; Desoxycorticosterone; Dexamethasone; Flunitrazepam; Glucocorticoids; Male; Mineralocorticoids; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 1992 |
Neurosteroids and GABAA receptor function.
Topics: Adrenalectomy; Animals; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Male; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Steroids; Stress, Psychological | 1992 |
5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam.
Topics: Alprazolam; Animals; Corticosterone; Corticotropin-Releasing Hormone; Desoxycorticosterone; Dexamethasone; Locus Coeruleus; Male; Median Eminence; Rats; Rats, Inbred Strains; Reference Values; Stress, Physiological | 1992 |
Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3a,21-dihydroxy-5a-pregnane-20-one.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthetics; Animals; Cerebral Cortex; Cerebral Ventricles; Desoxycorticosterone; Dopamine; Dose-Response Relationship, Drug; Exploratory Behavior; Homovanillic Acid; Injections, Intraventricular; Male; Motor Activity; Rats; Rats, Inbred Strains; Reference Values; Stress, Psychological | 1992 |
The 5,7-DHT-induced anticonflict effect is dependent on intact adrenocortical function.
Topics: 5,7-Dihydroxytryptamine; Adrenal Cortex; Adrenalectomy; Animals; Conflict, Psychological; Corticosterone; Desoxycorticosterone; Dexamethasone; Dose-Response Relationship, Drug; Drinking Behavior; Electroshock; Male; Rats; Rats, Inbred Strains; Sensory Thresholds | 1992 |
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes | 1991 |
Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Darkness; Desoxycorticosterone; Exploratory Behavior; Light; Male; Mice; Pregnanolone; Progesterone; Pyrazoles; Stereoisomerism | 1991 |
Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.
Topics: 20-alpha-Dihydroprogesterone; Animals; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Proteins; Pregnanolone; Rats; Receptors, GABA-A; Steroids; Structure-Activity Relationship; Synaptosomes | 1990 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.
Topics: Adrenalectomy; Animals; Brain; Cerebral Cortex; Desoxycorticosterone; Hypothalamus; Male; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming | 1991 |
Steroid modulation of the GABAA receptor complex: electrophysiological studies.
Topics: Anesthetics; Animals; Cattle; Chromaffin System; Desoxycorticosterone; Electrophysiology; Hippocampus; Membrane Proteins; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A; Steroids | 1990 |
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
Topics: Anesthetics; Animals; Chlorides; Desoxycorticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Nipecotic Acids; Pentobarbital; Pregnanolone; Progesterone; Proline; Rats; Receptors, GABA-A; Synaptic Membranes | 1990 |
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes.
Topics: Acetates; Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Drug Synergism; Isomerism; Male; Molecular Conformation; Muscimol; Pregnanes; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 1990 |
Neurosteroids act on recombinant human GABAA receptors.
Topics: Benzodiazepines; Cell Line, Transformed; Cell Membrane Permeability; Chlorides; Desoxycorticosterone; Electric Conductivity; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Pentobarbital; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Transfection | 1990 |
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
Topics: 20-alpha-Dihydroprogesterone; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chlorides; Desoxycorticosterone; Drug Synergism; Flunitrazepam; Hippocampus; In Vitro Techniques; Ion Channels; Progesterone; Rats; Receptors, GABA-A; Spinal Cord | 1986 |
Evidence of formation of isomeric methoximes from 20-oxosteroids.
Topics: Chromatography, Gas; Desoxycorticosterone; Gas Chromatography-Mass Spectrometry; Isomerism; Oximes | 1989 |
Anxiolytic activity of an endogenous adrenal steroid.
Topics: Animals; Anti-Anxiety Agents; Conflict, Psychological; Desoxycorticosterone; Drug Evaluation, Preclinical; Exploratory Behavior; Male; Mice | 1986 |
Sleep induction by an adrenal steroid in the rat.
Topics: Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; Flurazepam; Male; Pregnenes; Rats; Rats, Inbred Strains; Sleep; Sleep, REM | 1987 |
Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice.
Topics: Aggression; Analgesia; Animals; Desoxycorticosterone; Flumazenil; Injections, Intraperitoneal; Male; Mice; Stereoisomerism | 1988 |
Elevated urinary 19-Nor-deoxycorticosterone glucuronide in Cushing's syndrome.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Aldosterone; Carcinoma; Cushing Syndrome; Desoxycorticosterone; Female; Humans; Hydrocortisone; Hypertension; Male; Middle Aged; Pituitary Neoplasms; Potassium | 1987 |
Glucocorticoid action on the growth and development of insects.
Topics: Aldosterone; Animals; Body Weight; Cortodoxone; Desoxycorticosterone; Glucocorticoids; Hemiptera; Hydrocortisone; Larva; Mineralocorticoids | 1987 |
Fecal steroid 21-dehydroxylase, a potential marker for colorectal cancer.
Topics: Adult; Aged; Animals; Cell Transformation, Neoplastic; Child, Preschool; Colonic Neoplasms; Cricetinae; Desoxycorticosterone; Feces; Feeding Behavior; Female; Humans; Infant; Intestinal Polyps; Male; Middle Aged; Mutagenicity Tests; New York; Pregnanolone; Rectal Neoplasms; Risk; South Africa; Steroid 21-Hydroxylase; Steroid Hydroxylases | 1983 |
Origin and production rates of deoxycorticosterone and deoxycorticosterone sulfate in men and nonpregnant women.
Topics: Adult; Carbon Radioisotopes; Desoxycorticosterone; Female; Humans; Kinetics; Male; Middle Aged; Tritium | 1983 |
Effects of deoxycorticosterone and its ring A-reduced derivatives on the nervous system.
Topics: Adrenalectomy; Animals; Brain; Desoxycorticosterone; Evoked Potentials; Neurons; Pons; Pregnanediones; Rats; Rats, Inbred Strains; Reticular Formation; Sciatic Nerve | 1982 |
Production rate of deoxycorticosterone in women during the follicular and luteal phases of the ovarian cycle: the role of extraadrenal 21-hydroxylation of circulating progesterone in deoxycorticosterone production.
Topics: Adult; Desoxycorticosterone; Female; Follicular Phase; Humans; Hydroxylation; Kinetics; Luteal Phase; Menstruation; Progesterone | 1980 |
The neuroactive steroid 5 alpha-tetrahydrodeoxycorticosterone increases GABAergic postsynaptic inhibition in rat neocortical neurons in vitro.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Desoxycorticosterone; Evoked Potentials; GABA Agonists; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptic Transmission | 1995 |
Functional diversity of GABAA receptor ligand-gated chloride channels in rat synaptoneurosomes.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Chlorides; Desoxycorticosterone; Ion Channel Gating; Ligands; Male; Muscimol; Pentobarbital; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes; Tissue Distribution | 1995 |
GABA binding sites: their density, their affinity to muscimol and their behaviour against neuroactive steroids in human gliomas of different degrees of malignancy.
Topics: Anti-Anxiety Agents; Brain Neoplasms; Desoxycorticosterone; Glioma; Humans; In Vitro Techniques; Membranes; Muscimol; Pregnanolone; Receptors, GABA; Steroids | 1994 |
Drug discrimination analysis of endogenous neuroactive steroids in rats.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Discrimination Learning; Ethanol; Generalization, Stimulus; Lorazepam; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A | 1993 |
Allosteric effects of a GABA receptor-active steroid are altered by stress.
Topics: Allosteric Regulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Desoxycorticosterone; Flunitrazepam; In Vitro Techniques; Ion Channel Gating; Kinetics; Male; Mice; Receptors, GABA; Stress, Physiological | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Clonazepam; Desoxycorticosterone; Flumazenil; Imidazoles; Indoleacetic Acids; Isoniazid; Isoquinolines; Mitochondria; Phobic Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Seizures; Zolpidem | 1993 |
Brain region-specific effects of neuroactive steroids on the affinity and density of the GABA-binding site.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Hippocampus; Hypothalamus; Medulla Oblongata; Muscimol; Pregnanediones; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Studies on picrotoxin binding sites of GABAA receptors in rat cortical synaptoneurosomes.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorine; Desoxycorticosterone; Diazepam; In Vitro Techniques; Male; Membranes; Muscimol; Pentobarbital; Picrotoxin; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Synaptosomes | 1994 |
Decreased forebrain [35S]TBPS binding and increased [3H]muscimol binding in rats that do not develop stress-induced behavioral depression.
Topics: Adrenalectomy; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Depression; Desoxycorticosterone; Electroshock; Flunitrazepam; Helplessness, Learned; Male; Muscimol; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Psychological | 1993 |
Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid.
Topics: Animals; Desoxycorticosterone; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Male; Midazolam; Rats; Rats, Inbred WF; Receptors, GABA-A; Steroids | 1993 |
3 alpha-OH-DHP and 5 alpha-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus.
Topics: Anesthetics; Animals; Cricetinae; Desoxycorticosterone; Drug Implants; Estradiol; Female; Mesocricetus; Ovariectomy; Posture; Pregnanolone; Progesterone; Sexual Behavior, Animal; Tegmentum Mesencephali; Ventromedial Hypothalamic Nucleus | 1993 |
A new highly sensitive procedure--a prerequisite to evaluate the density of GABAA receptors and to study their allosteric properties in distinct areas of rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Importance of hypothalamic function to stressor-induced responsiveness of the GABAA receptor in the cerebral cortex: a non-corticosterone influence.
Topics: Anesthetics; Animals; Behavior, Animal; Cerebral Cortex; Chlorides; Corticosterone; Desoxycorticosterone; Dopamine beta-Hydroxylase; Hypothalamus; Interpersonal Relations; Male; Norepinephrine; Oxidopamine; Paraventricular Hypothalamic Nucleus; Rats; Receptors, GABA-A; Stress, Psychological | 1993 |
The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors | 1993 |
Progesterone receptor-mediated effects of neuroactive steroids.
Topics: Base Sequence; Desoxycorticosterone; DNA; Gene Expression Regulation; Humans; Intracellular Membranes; Molecular Sequence Data; Neurons; Oxidation-Reduction; Pregnanolone; Receptors, Progesterone; Steroids; Tumor Cells, Cultured | 1993 |
Effect of neuroactive steroids on [3H]flumazenil binding to the GABAA receptor complex in vitro.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Desoxycorticosterone; Dose-Response Relationship, Drug; Flumazenil; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.
Topics: Animals; Bicuculline; Cells, Cultured; Desoxycorticosterone; Drug Synergism; GABA Antagonists; GABA Modulators; Hypothalamus; Neurons; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Somatostatin | 1995 |
Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice.
Topics: Adrenalectomy; Allosteric Regulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Corticotropin-Releasing Hormone; Desoxycorticosterone; GABA-A Receptor Antagonists; Male; Methoxamine; Mice; Mice, Inbred Strains; Pentobarbital; Pregnenolone; Receptors, GABA-A; Sleep; Social Behavior; Social Isolation; Stress, Psychological; Yohimbine | 1996 |
Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Dose-Response Relationship, Drug; Ethanol; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Steroids; Substance Withdrawal Syndrome | 1996 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
Delta subunit inhibits neurosteroid modulation of GABAA receptors.
Topics: Allosteric Regulation; Anesthetics; Animals; Cells, Cultured; Cerebellum; Chlorides; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Agonists; Gene Expression Regulation, Developmental; Ion Channel Gating; Membrane Potentials; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1996 |
Steroid modulation of central nervous GABAA receptor binding in three female rat brain areas during postnatal development.
Topics: Animals; Brain; Brain Chemistry; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; GABA Agonists; Medulla Oblongata; Membranes; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Regression Analysis; Steroids | 1995 |
Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity.
Topics: 5-alpha-Dihydroprogesterone; Anesthetics; Animals; Behavior, Animal; Desoxycorticosterone; Drug Synergism; Estradiol; Female; Injections, Intraventricular; Ovariectomy; Pain Threshold; Pregnanediones; Progesterone; Rats; Reaction Time; Steroids | 1996 |
Neurosteroid modulation of the benzodiazepine receptor in developing chick optic lobe.
Topics: Animals; Anti-Anxiety Agents; Chick Embryo; Chickens; Desoxycorticosterone; Dose-Response Relationship, Drug; Flunitrazepam; Isomerism; Kinetics; Neuroprotective Agents; Pregnanolone; Receptors, GABA-A; Tectum Mesencephali | 1996 |
Effect of the neuroactive steroid alpha-THDOC on staircase test behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; GABA Modulators; Male; Mice; Mice, Inbred ICR; Motor Activity; Phenobarbital | 1996 |
The role of neurosteroids in alcohol-related behaviors: new studies from the laboratory and clinic.
Topics: Affect; Alcoholism; Animals; Arousal; Behavior, Animal; Brain; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Gonadal Steroid Hormones; Hormones; Humans; Male; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 1996 |
17 alpha-Hydroxylase deficiency: 1963-1966.
Topics: Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Desoxycorticosterone; Female; Glucocorticoids; History, 20th Century; Humans; Renin | 1997 |
Isoniazid-induced inhibition of GABAergic transmission enhances neurosteroid content in the rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Carbolines; Desoxycorticosterone; Electroshock; GABA Antagonists; GABA-A Receptor Antagonists; Isoniazid; Male; Neurotransmitter Agents; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Steroids | 1996 |
Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Desoxycorticosterone; Electrophysiology; Female; In Vitro Techniques; Models, Molecular; Oocytes; Rats; Receptors, GABA-A; Xenopus | 1997 |
Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.
Topics: Adrenal Cortex; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Corticotropin-Releasing Hormone; Desoxycorticosterone; Female; GABA Antagonists; Glucocorticoids; Hippocampus; Humans; Hypothalamus; In Situ Hybridization; Infant, Newborn; Male; Neurosecretory Systems; Pregnancy; Rats; Rats, Wistar; Receptors, GABA; Receptors, Glucocorticoid; RNA, Messenger; Stress, Physiological; Transcription, Genetic | 1997 |
Influence of gender and brain region on neurosteroid modulation of GABA responses in rats.
Topics: Amygdala; Androgens; Androsterone; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Rats; Sex Characteristics | 1997 |
Neurosteroid prolongs GABAA channel deactivation by altering kinetics of desensitized states.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Cerebellum; Desoxycorticosterone; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Taurine | 1997 |
Partial agonism by 3alpha,21-dihydroxy-5beta-pregnan-20-one at the gamma-aminobutyric acidA receptor neurosteroid site.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 1997 |
Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids.
Topics: Animals; Corticotropin-Releasing Hormone; Desoxycorticosterone; Dose-Response Relationship, Drug; Ginsenosides; Hormone Antagonists; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Peptide Fragments; Pregnenolone; Receptors, GABA-A; Saponins; Sleep; Social Isolation; Stress, Physiological | 1997 |
Pre- and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5 beta-pregnan-3 alpha-ol-20-one.
Topics: Anesthetics; Animals; Desoxycorticosterone; Electrophysiology; gamma-Aminobutyric Acid; Larva; Motor Neurons; Neural Inhibition; Neurotransmitter Agents; Pregnanediones; Pregnanes; Receptors, GABA-A; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Xenopus laevis | 1997 |
Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Male; Maze Learning; Mice; Mice, Inbred DBA; Pregnanediones; Pregnanolone; Steroids | 1998 |
Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Chloride Channels; Desoxycorticosterone; Enzyme Activation; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Phorbol Esters; Pregnenolone; Protein Kinase C; Receptors, GABA-A; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 1997 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Influence of gender on chronic ethanol-induced alterations in GABAA receptors in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Convulsants; Desoxycorticosterone; Diazepam; Differential Threshold; Drug Resistance; Ethanol; Female; Gene Expression; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics; Substance Withdrawal Syndrome; Time Factors | 1998 |
Functional characterization and visualization of a GABAA receptor-GFP chimera expressed in Xenopus oocytes.
Topics: Anesthetics; Animals; Bicuculline; Cell Membrane; Desoxycorticosterone; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indicators and Reagents; Ion Channel Gating; Luminescent Proteins; Membrane Potentials; Microscopy, Confocal; Midazolam; Oocytes; Pentobarbital; Picrotoxin; Receptors, GABA-A; Recombinant Fusion Proteins; Xenopus laevis | 1998 |
Neuroactive steroids induce GABA(A) receptor-mediated depolarizing postsynaptic potentials in hippocampal CA1 pyramidal cells of the rat.
Topics: Animals; Cells, Cultured; Culture Techniques; Desoxycorticosterone; Electric Stimulation; Excitatory Postsynaptic Potentials; Interneurons; Male; Microelectrodes; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A | 1998 |
Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chlorides; Desoxycorticosterone; Estrus; Female; Finasteride; Gene Expression Regulation; Hippocampus; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic | 1998 |
Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei.
Topics: Action Potentials; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Epilepsy, Absence; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Pentobarbital; Pregnanediones; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes; Thalamic Nuclei | 1998 |
Neuroactive steroids exacerbate gamma-hydroxybutyric acid-induced absence seizures in rats.
Topics: Anesthetics; Animals; Desoxycorticosterone; Epilepsy, Absence; Hydroxybutyrates; Male; Pregnanediones; Rats; Rats, Sprague-Dawley; Thalamic Nuclei | 1998 |
Steroid-inhibition of [3H]gamma-hydroxybutyric acid (GHB) binding in thalamic relay nuclei increases during absence seizures.
Topics: Anesthetics; Animals; Binding, Competitive; Cerebral Cortex; Desoxycorticosterone; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neurons; Parietal Lobe; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thalamus; Tritium; Up-Regulation | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery.
Topics: Adult; Analysis of Variance; Antidepressive Agents; Case-Control Studies; Depressive Disorder; Desoxycorticosterone; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Progesterone; Prospective Studies; Steroids | 1999 |
Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons.
Topics: Animals; Cells, Cultured; Chloride Channels; Desoxycorticosterone; gamma-Aminobutyric Acid; Hypothalamus; Rats; Synapses | 1999 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Inflammatory Agents; Desoxycorticosterone; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA; Receptors, Purinergic P1; Xenopus laevis | 1999 |
Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies.
Topics: Animals; Cloning, Molecular; Desoxycorticosterone; Female; Humans; Imidazoles; Isoquinolines; Ligands; Male; Oocytes; Pregnenolone; Progesterone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Xenopus | 1999 |
Interactive role for neurosteroids in ethanol enhancement of gamma-aminobutyric acid-gated currents from dissociated substantia nigra reticulata neurons.
Topics: Anesthetics; Animals; Cells, Cultured; Central Nervous System Depressants; Desoxycorticosterone; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Ion Channel Gating; Neurons; Patch-Clamp Techniques; Pregnanediones; Rats; Steroids; Substantia Nigra | 1999 |
Effects of a naturally occurring neurosteroid on GABAA IPSCs during development in rat hippocampal or cerebellar slices.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Hippocampus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Synaptic Transmission | 1999 |
Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Brain; Cerebral Cortex; Desoxycorticosterone; Ethanol; Hippocampus; Injections, Intraperitoneal; Male; Rats; Receptors, GABA | 1999 |
Cortisol metabolism in the postoperative period after cardiac surgery.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Aged; Aged, 80 and over; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Corticosterone; Cortodoxone; Desoxycorticosterone; Female; Humans; Hydrocortisone; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Postoperative Period; Water-Electrolyte Balance | 1999 |
Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?
Topics: Animals; Central Nervous System Depressants; Cerebral Cortex; Conditioning, Operant; Desoxycorticosterone; Ethanol; Female; Haplorhini; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1999 |
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.
Topics: Allosteric Regulation; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Corticosterone; Dendrites; Desoxycorticosterone; Drug Implants; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2001 |
Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP.
Topics: Animals; Anxiety; Behavior, Animal; Desoxycorticosterone; Estrus; Female; Hippocampus; Male; Progesterone; Rats; Rats, Long-Evans; Sex Factors | 2000 |
Assembly of functional alpha6beta3gamma2delta GABA(A) receptors in vitro.
Topics: Affinity Labels; Anesthetics; Animals; Anticonvulsants; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Desoxycorticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Muscimol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Transfection; Triazoles; Tritium | 2000 |
Prolonged exposure to hypobaric hypoxia transiently reduces GABA(A) receptor number in mice cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; GABA Modulators; Hypoxia, Brain; Male; Mice; Pentobarbital; Receptors, GABA-A | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment.
Topics: Adolescent; Aging; Alcohol-Induced Disorders, Nervous System; Animals; Anti-Anxiety Agents; Brain; Chloride Channels; Chlorine; Chronic Disease; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Ethanol; GABA Agonists; Humans; Male; Muscimol; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 2001 |
Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Desoxycorticosterone; Haloperidol; Male; Neurotransmitter Agents; Orchiectomy; Progesterone; Rats; Rats, Sprague-Dawley; Steroids | 2001 |
Increased expression of the neuropeptide Y receptor Y(1) gene in the medial amygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone.
Topics: Amygdala; Animals; Cerebral Cortex; Desoxycorticosterone; Female; Gene Expression; Mice; Mice, Transgenic; Osmolar Concentration; Pregnanolone; Progesterone; Receptors, Neuropeptide Y; Time Factors | 2001 |
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Anti-Anxiety Agents; Biological Transport; Cerebral Cortex; Chlorine; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Labor, Obstetric; Male; Muscimol; Pregnancy; Pregnanolone; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Characteristics | 2001 |
Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.
Topics: Allosteric Regulation; Animals; Cell Line; Desoxycorticosterone; Dose-Response Relationship, Drug; Fibroblasts; gamma-Aminobutyric Acid; Gene Expression; Humans; Ion Channel Gating; Kidney; Patch-Clamp Techniques; Protein Isoforms; Protein Subunits; Rats; Receptors, GABA-A; Transfection | 2002 |
The effects of the neuroactive steroid 3 alpha,5 alpha-THDOC on sleep in the rat.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Dose-Response Relationship, Drug; Electroencephalography; Gonadal Steroid Hormones; Male; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Sleep | 2002 |
Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility.
Topics: 5-alpha Reductase Inhibitors; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Convulsants; Corticosterone; Desoxycorticosterone; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Antagonism; Drug Resistance; Enzyme Inhibitors; Exercise Test; Finasteride; Indomethacin; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Steroids; Stress, Physiological | 2002 |
GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.
Topics: Animals; Baclofen; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hippocampus; Hydroxybutyrates; Male; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-B | 2002 |
Antinociceptive activity of a neurosteroid tetrahydrodeoxycorticosterone (5alpha-pregnan-3alpha-21-diol-20-one) and its possible mechanism(s) of action.
Topics: Analgesics; Animals; Desoxycorticosterone; GABA-A Receptor Antagonists; Male; Mice | 2001 |
A rapid method for obtaining finasteride, a 5alpha-reductase inhibitor, from commercial tablets.
Topics: 5-alpha Reductase Inhibitors; Animals; Cerebral Cortex; Chemistry, Pharmaceutical; Chromatography; Desoxycorticosterone; Dopamine; Enzyme Inhibitors; Finasteride; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Stress, Physiological; Time Factors | 2002 |
Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Desoxycorticosterone; Electroshock; Fluoxetine; Male; Mianserin; Mirtazapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Stress, Psychological | 2002 |
Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol.
Topics: Alcoholism; Animals; Body Temperature; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Pregnenolone | 2002 |
Membrane-initiated events account for progesterone's ability to regulate intracellular free calcium levels and inhibit rat granulosa cell mitosis.
Topics: Animals; Bicuculline; Blotting, Western; Calcium; Cell Separation; Cells, Cultured; Desoxycorticosterone; Female; GABA Antagonists; Granulosa Cells; Immunohistochemistry; Indicators and Reagents; Insulin; Ligands; Membrane Proteins; Membranes; Mitosis; Progesterone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery.
Topics: Amygdala; Animals; Cerebral Cortex; Desoxycorticosterone; Enzyme Inhibitors; Female; Finasteride; Gene Expression Regulation; Genes, Reporter; In Situ Hybridization; Mice; Mice, Transgenic; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Receptors, Neuropeptide Y; RNA, Messenger; Transgenes | 2002 |
Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit.
Topics: Amino Acid Sequence; Animals; Desoxycorticosterone; Electric Stimulation; Electrophysiology; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isomerism; Membrane Potentials; Molecular Sequence Data; Neurotransmitter Agents; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Recombinant Fusion Proteins; Recombinant Proteins | 2002 |
GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons.
Topics: Animals; Cerebellum; Cytoplasmic Granules; Desoxycorticosterone; Electrophysiology; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Protein Kinase C; Receptors, GABA-A; RNA, Messenger; Steroids; Synapses | 2002 |
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids | 2003 |
Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.
Topics: Anesthetics; Animals; Desoxycorticosterone; Evoked Potentials; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neural Pathways; Pregnenolone; Receptors, GABA-A; Synapses; Thalamus | 2003 |
Neurosteroid secretion in panic disorder.
Topics: Adult; Analysis of Variance; Case-Control Studies; Dehydroepiandrosterone; Desoxycorticosterone; Female; Humans; Panic Disorder; Pregnenolone; Progesterone | 2003 |
Effects of olanzapine infusions to the ventral tegmental area on lordosis and midbrain 3alpha,5alpha-THP concentrations in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzodiazepines; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Infusion Pumps; Mesencephalon; Olanzapine; Ovariectomy; Posture; Progesterone; Radioimmunoassay; Rats; Rats, Long-Evans; Selective Serotonin Reuptake Inhibitors; Sexual Behavior, Animal; Ventral Tegmental Area | 2003 |
Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Anxiety Disorders; Berberine Alkaloids; Brain; Castration; Corticosterone; Desoxycorticosterone; Female; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Male; Pregnancy; Rats; Rats, Wistar; RNA, Messenger; Sex Characteristics; Time Factors | 2003 |
[Composition of adrenal medullar hormone, secreted under different experimental conditions].
Topics: Adrenal Medulla; Biochemical Phenomena; Desoxycorticosterone; Hormones; Humans | 1952 |
Effects of adrenal medullary hormones on renal excretion of water and electrolytes.
Topics: Desoxycorticosterone; Electrolytes; Epinephrine; Humans; Kidney; Norepinephrine; Renal Elimination; Water | 1952 |
Effects of adrenal medullary hormones on antidiuretic substance in blood serum.
Topics: Blood; Desoxycorticosterone; Diuresis; Epinephrine; Norepinephrine; Serum | 1954 |
Further studies on the effects of adrenal medullary hormones on renal excretion of water and electrolytes in the intact rat.
Topics: Adrenal Medulla; Animals; Desoxycorticosterone; Electrolytes; Hormones; Kidney; Rats; Renal Elimination; Water | 1954 |
A study of the mode of action of the adrenal medullary hormones on sodium, potassium and water excretion in man.
Topics: Body Fluids; Desoxycorticosterone; Epinephrine; Norepinephrine; Potassium; Sodium; Sodium, Dietary; Water | 1954 |
Effects of the medullary hormones on the somatic nervous system in the cat.
Topics: Animals; Cats; Central Nervous System; Desoxycorticosterone; Epinephrine; Felis; Norepinephrine | 1955 |
[Seasonal variations of adrenalin and noradrenalin content of the adrenals of toads].
Topics: Adrenal Glands; Adrenal Medulla; Animals; Bufonidae; Desoxycorticosterone; Epinephrine; Hormones; Norepinephrine; Seasons | 1956 |
Some relationships between adrenal medullary and cortical substances and exocrine function of the pancreas in man.
Topics: Adrenal Cortex Hormones; Adrenal Medulla; Desoxycorticosterone; Hormones; Humans; Male; Pancreas | 1956 |
[Effect of the adrenal medulla hormone on the kidney blood supply in mouse].
Topics: Adrenal Medulla; Animals; Cardiovascular System; Desoxycorticosterone; Epinephrine; Kidney; Mice | 1957 |
Studies on the adrenocortical, adreno-medullary and adrenergic nerve activity in essential hypertension.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenergic Agents; Desoxycorticosterone; Essential Hypertension; Hormones; Hypertension | 1957 |
The physiological significance of the adrenomedullary secretion.
Topics: Adrenal Medulla; Desoxycorticosterone; Hormones; Humans; Sympathetic Nervous System | 1958 |
Factors influencing the neural and hormonal (adrenomedullary) components of the sympatheticoadrenal discharge.
Topics: Adrenal Medulla; Body Fluids; Desoxycorticosterone; Hormones; Humans; Sympathetic Nervous System | 1958 |
The distribution of the catechol amines in homogenates of the bovine adrenal medulla.
Topics: Adrenal Medulla; Amines; Animals; Catechols; Cattle; Desoxycorticosterone; Epinephrine; Hormones; Norepinephrine; Tyramine | 1958 |
[Site of hormone formation in the adrenal medulla].
Topics: Adrenal Medulla; Desoxycorticosterone; Hormones; Humans; Meridians | 1958 |
[On the medullary-adrenal excito-secretion effect of histamine].
Topics: Adrenal Medulla; Cardiovascular System; Desoxycorticosterone; Epinephrine; Histamine; Histamine Agents; Hormones | 1958 |
[Drainage of the adrenal medulla and the secretion of noradrenalin].
Topics: Adrenal Medulla; Body Fluids; Desoxycorticosterone; Drainage; Hormones; Norepinephrine | 1958 |
Effect of irradiation to adrenal upon circulating adrenal medullary hormone in the rat.
Topics: Adrenal Glands; Animals; Desoxycorticosterone; Epinephrine; Norepinephrine; Rats | 1961 |
Functional relationship between adrenal medullary and cortical hormones in man.
Topics: Adrenal Cortex Hormones; Adrenal Medulla; Desoxycorticosterone; Hormones; Humans | 1961 |
Factors influencing the selective secretion of adrenal medullary hormones.
Topics: Adrenal Medulla; Desoxycorticosterone; Epinephrine; Norepinephrine | 1961 |
THE INFLUENCE OF ADRENAL MEDULLARY HORMONES ON NEPHROTOXIC NEPHRITIS IN RABBITS.
Topics: Animals; Antigen-Antibody Reactions; Desoxycorticosterone; Epinephrine; Fluorescent Antibody Technique; gamma-Globulins; Nephritis; Norepinephrine; Pharmacology; Poultry; Rabbits; Research; Toxicology | 1964 |
Some effects of single, subcutaneous injections of adrenal medullary hormones on renal excretion of water and electrolytes in the dog.
Topics: Animals; Desoxycorticosterone; Dogs; Electrolytes; Epinephrine; Ergot Alkaloids; Humans; Injections, Subcutaneous; Kidney; Norepinephrine; Renal Elimination; Water | 1955 |
Adrenal medullary hormones and arteriosclerosis.
Topics: Arteriosclerosis; Desoxycorticosterone; Epinephrine; Humans | 1959 |
[Identification of the glucosiduronate of 5beta-pregnane-3alpha,21-diol-20-one (THDOC) after the administration of cortexone].
Topics: Desoxycorticosterone; Glucuronates; Neurotransmitter Agents; Pregnanediol; Pregnanes | 1961 |
Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.
Topics: Animals; Cerebellum; Dentate Gyrus; Desoxycorticosterone; Electrophysiology; Female; Hippocampus; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Receptors, GABA-A; Steroids | 2003 |
Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns.
Topics: Allosteric Regulation; beta-Alanine; Cell Line; Desoxycorticosterone; Fibroblasts; GABA Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Receptors, GABA-A; Steroids; Taurine; Transfection | 2003 |
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
Topics: Adrenalectomy; Animals; Brain; Desoxycorticosterone; Ethanol; Male; Orchiectomy; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 2004 |
Adrenal medullary hormones in water diuresis.
Topics: Adrenal Glands; Desoxycorticosterone; Diuresis; Diuretics | 1950 |
The effect of the chronic administration of adrenal medullary hormones to man on adrenocortical function and the renal excretion of electrolytes.
Topics: Adrenal Cortex; Desoxycorticosterone; Electrolytes; Epinephrine; Humans; Male; Pharmaceutical Preparations; Renal Elimination | 1951 |
[Changes in composition of adrenal medullar hormone by electrical irritation of the hypothalamus].
Topics: Adrenal Medulla; Desoxycorticosterone; Hormones; Humans; Hypothalamus | 1952 |
The secretion of the denervated adrenal medulla of the cat.
Topics: Adrenal Medulla; Animals; Cats; Desoxycorticosterone; Felis; Hormones | 1952 |
Fluoxetine may influence lordosis of rats through effects on midbrain 3 alpha,5 alpha-THP concentrations.
Topics: Animals; Desoxycorticosterone; Female; Fluoxetine; Mesencephalon; Ovariectomy; Posture; Rats; Rats, Long-Evans; Sexual Behavior, Animal | 2003 |
Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Conserved Sequence; Desoxycorticosterone; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA-A Receptor Agonists; Humans; Molecular Sequence Data; Oocytes; Pregnanolone; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis; Xenopus Proteins | 2004 |
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values | 2004 |
Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study.
Topics: Adult; Analysis of Variance; Circadian Rhythm; Clozapine; Desoxycorticosterone; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pregnanolone; Prospective Studies; Schizophrenia | 2004 |
Effect of pregnancy and 5alpha-pregnan-3alpha-ol-20-one on atrial receptor afferent discharge in rats.
Topics: Afferent Pathways; Animals; Desoxycorticosterone; Dilatation; Female; Heart Atria; Pregnancy; Pregnancy, Animal; Rats; Rats, Long-Evans | 2004 |
Effects of the active neurosteroid allotetrahydrodeoxycorticosterone on long-term potentiation in the rat hippocampus: implications for depression.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley | 2004 |
Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.
Topics: Animals; Brain; Densitometry; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Immunohistochemistry; Interneurons; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Neurons; Pilocarpine; Receptors, GABA-A | 2004 |
Panic induction with cholecystokinin-tetrapeptide (CCK-4) Increases plasma concentrations of the neuroactive steroid 3alpha, 5alpha tetrahydrodeoxycorticosterone (3alpha, 5alpha-THDOC) in healthy volunteers.
Topics: Adrenocorticotropic Hormone; Adult; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Male; Panic; Psychiatric Status Rating Scales; Steroids; Tetragastrin | 2005 |
In the ventral tegmental area, G-proteins and cAMP mediate the neurosteroid 3alpha,5alpha-THP's actions at dopamine type 1 receptors for lordosis of rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Bromo Cyclic Adenosine Monophosphate; Analysis of Variance; Animals; Behavior, Animal; Benzazepines; Cyclic AMP; Desoxycorticosterone; Drug Interactions; Female; GTP-Binding Proteins; Guanosine Diphosphate; Male; Models, Biological; Posture; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Sexual Behavior, Animal; Thionucleotides; Ventral Tegmental Area | 2004 |
Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; 5-alpha-Dihydroprogesterone; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Brain; Catalysis; Desoxycorticosterone; Female; Humans; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Oxidation-Reduction; Receptors, GABA-A | 2005 |
Preliminary evidence for an association between aggressive and hostile behaviour and 3alpha,5alpha-tetrahydroprogesterone plasma levels in schizophrenia.
Topics: Adult; Aggression; Desoxycorticosterone; Female; Humans; Male; Schizophrenia | 2005 |
Attenuating 5alpha-pregnane-3alpha-ol-20-one formation in the hippocampus of female rats increases pentylenetetrazole-induced seizures.
Topics: Animals; Behavior, Animal; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Female; Finasteride; Hippocampus; Ovariectomy; Pentylenetetrazole; Progesterone; Radioimmunoassay; Rats; Rats, Long-Evans; Seizures | 2005 |
Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the gamma-aminobutyric acid-A receptor.
Topics: Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glucocorticoids; Male; Neurons; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2005 |
High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABA A receptors by neurosteroids and GABA agonists.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A | 2005 |
Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone rats.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Genetic Predisposition to Disease; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Rats, Wistar; Seizures | 2005 |
Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response.
Topics: Alcoholism; Analysis of Variance; Animals; Brain; Desoxycorticosterone; Drug Administration Schedule; Ethanol; Injections; Male; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric | 2005 |
Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder.
Topics: Adolescent; Adult; Anxiety; Dehydroepiandrosterone; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Humans; Male; Panic Disorder; Pregnanolone; Progesterone; Steroids; Surveys and Questionnaires | 2005 |
Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny.
Topics: Age Factors; Anesthetics; Animals; Animals, Newborn; Convulsants; Desoxycorticosterone; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Pentylenetetrazole; Pregnanolone; Rats; Rats, Wistar | 2006 |
The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.
Topics: Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Isoflurane; Male; Mice; Mice, Inbred C57BL; Protein Subunits; Rats; Receptors, GABA-A; Xenopus laevis | 2006 |
Anticonvulsant action of three neurosteroids against cortical epileptic afterdischarges in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Pregnanolone; Rats; Seizures | 2005 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Finasteride; Mineralocorticoid Receptor Antagonists; Pentylenetetrazole; Rats; Receptors, GABA; Receptors, Mineralocorticoid; Receptors, Progesterone; Seizures; Spironolactone | 2005 |
Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis.
Topics: Aging; Animals; Desoxycorticosterone; Estradiol; Female; GABA Agonists; Injections, Intravenous; Injections, Subcutaneous; Mice; Mice, Knockout; Muscimol; Posture; Progesterone; Radioimmunoassay; Receptors, GABA; Receptors, Progesterone; Sexual Behavior, Animal | 2006 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2006 |
In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABA A receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Bicuculline; Cricetinae; Desoxycorticosterone; Dopamine Agonists; Female; GABA Antagonists; Injections; Male; Motor Activity; Posture; Progestins; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Receptors, GABA-A; Sexual Behavior, Animal; Species Specificity; Steroids; Ventral Tegmental Area | 2006 |
Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder.
Topics: Adult; Anti-Inflammatory Agents; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Hydrocortisone; Pregnanolone; Premenopause; Premenstrual Syndrome; Progesterone; Radioimmunoassay; Steroids | 2006 |
Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Desoxycorticosterone; DNA, Complementary; Electrophysiology; Fluorescent Antibody Technique; Gene Expression; Neuronal Plasticity; Patch-Clamp Techniques; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Tonic GABA(A) receptor-mediated currents in human brain.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Electrophysiology; GABA Antagonists; Humans; Interneurons; Membrane Potentials; Neurons; Picrotoxin; Pyridazines; Receptors, GABA-A | 2006 |
Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.
Topics: Androstane-3,17-diol; Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediol; Pregnanes; Pregnenolone; Protein Subunits; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Steroids; Xenopus laevis; Zolpidem | 2006 |
GABAergic tonic inhibition of substantia gelatinosa neurons in mouse spinal cord.
Topics: Action Potentials; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Drug Interactions; Furosemide; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Potassium Chloride Symporter Inhibitors; Spinal Cord; Substantia Gelatinosa | 2006 |
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Amygdala; Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Desoxycorticosterone; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Membrane Proteins; Mice; Neurons; Olfactory Bulb; Pregnanolone; Rats; RNA, Messenger; Thalamus | 2006 |
Kindling-induced alterations in GABAA receptor-mediated inhibition and neurosteroid activity in the rat piriform cortex.
Topics: Amygdala; Animals; Cerebral Cortex; Desoxycorticosterone; Electric Stimulation; Functional Laterality; History, Ancient; Immunohistochemistry; In Vitro Techniques; Kindling, Neurologic; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2006 |
Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Olanzapine; Pregnanolone; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2006 |
Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzodiazepines; Desoxycorticosterone; GABA Agonists; GABA Modulators; Imidazoles; In Vitro Techniques; Midazolam; Neocortex; Neurons; Patch-Clamp Techniques; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatosensory Cortex; Zolpidem | 2007 |
Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus.
Topics: Action Potentials; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Ion Channel Gating; Kinetics; Male; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Sympathetic Nervous System; Synaptic Transmission | 2006 |
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.
Topics: Amino Acid Sequence; Binding Sites; Desoxycorticosterone; Electric Conductivity; Humans; Molecular Sequence Data; Patch-Clamp Techniques; Pregnanolone; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-A | 2006 |
The neurosteroid THDOC differentially affects spatial behavior and anesthesia in Slow and Fast kindling rat strains.
Topics: Anesthesia; Anesthetics; Animals; Desoxycorticosterone; Discrimination Learning; GABA Modulators; Inhibitory Postsynaptic Potentials; Kindling, Neurologic; Maze Learning; Rats; Rats, Inbred Strains; Rats, Long-Evans; Rats, Wistar; Spatial Behavior; Species Specificity | 2007 |
Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress.
Topics: Animals; Corticosterone; Desoxycorticosterone; Female; Finasteride; Hippocampus; Male; Menstrual Cycle; Mice; Mice, Inbred C57BL; Mifepristone; Neuronal Plasticity; Patch-Clamp Techniques; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Stress, Physiological; Tamoxifen | 2007 |
Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.
Topics: Action Potentials; Animals; beta-Alanine; Bicuculline; Crotonates; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Furosemide; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Microinjections; Mutation; Neural Inhibition; Neurons; Oocytes; Picrotoxin; Pyridazines; Rats; Receptors, GABA-A; Sesterterpenes; Taurine; Xenopus laevis; Zinc | 2007 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei.
Topics: Animals; Bicuculline; Data Interpretation, Statistical; Desoxycorticosterone; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Membrane Potentials; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Steroids; Synaptic Transmission; Vestibular Nuclei | 2007 |
Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy.
Topics: Animals; Benzodiazepines; Dendrites; Dentate Gyrus; Desoxycorticosterone; Epilepsy; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Pilocarpine; Protein Isoforms; Receptors, GABA-A; Synapses; Tissue Distribution | 2007 |
GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids.
Topics: Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Female; GABA Antagonists; GABA Modulators; Glycine Agents; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Neural Inhibition; Posterior Horn Cells; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synaptic Transmission | 2007 |
PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids.
Topics: Alkaloids; Animals; Benzophenanthridines; Desoxycorticosterone; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Finasteride; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Isoquinolines; Membrane Potentials; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Spinal Cord; Steroids | 2007 |
Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats.
Topics: Animals; Anxiety; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Diencephalon; Estradiol; Estrous Cycle; Exploratory Behavior; Female; Hippocampus; Mesencephalon; Microinjections; Motor Activity; Posture; Progesterone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Steroids; Vagina; Ventral Tegmental Area | 2008 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids.
Topics: Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Gene Expression; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Protein Subunits; Pyrazoles; Rats; Receptors, GABA-A; Xenopus laevis | 2008 |
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroencephalography; Epilepsy; Estradiol; Female; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Premenstrual Syndrome; Progesterone; Receptors, GABA | 2008 |
Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex.
Topics: Anesthetics; Animals; Animals, Newborn; Desoxycorticosterone; Drug Interactions; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Mice; Neocortex; Neural Inhibition; Neurons; Patch-Clamp Techniques; Reaction Time; Receptors, GABA-A | 2008 |
Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Brain Chemistry; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Indomethacin; Male; Molecular Structure; Motor Activity; Portacaval Shunt, Surgical; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2008 |
GABAA receptor-mediated tonic currents in substantia gelatinosa neurons of rat spinal trigeminal nucleus pars caudalis.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Membrane Potentials; Neural Inhibition; Neurons; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Receptors, Glycine; Substantia Gelatinosa; Synaptic Transmission; Trigeminal Caudal Nucleus | 2008 |
Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area.
Topics: Animals; Antineoplastic Agents; Anxiety; Behavior, Animal; Cyclooxygenase Inhibitors; Desoxycorticosterone; Estrus; Exploratory Behavior; Female; Indomethacin; Isoquinolines; Microinjections; Motor Activity; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area | 2008 |
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Disease Models, Animal; Down-Regulation; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neuronal Plasticity; Pregnanolone; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Stress, Psychological; Synapses; Synaptic Transmission; Thalamus; Up-Regulation | 2008 |
In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Desoxycorticosterone; Dopamine Agonists; Enzyme Inhibitors; Estradiol; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Membranes; Ovariectomy; Progestins; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Second Messenger Systems; Sexual Behavior, Animal; Stereotaxic Techniques; Type C Phospholipases; Ventral Tegmental Area | 2008 |
Conserved site for neurosteroid modulation of GABA A receptors.
Topics: Animals; Binding Sites; Cell Line, Transformed; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Ion Channel Gating; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurotransmitter Agents; Patch-Clamp Techniques; Pregnanolone; Protein Subunits; Receptors, GABA-A; Transfection | 2009 |
Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells.
Topics: Cell Line, Transformed; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Ethanol; Etomidate; gamma-Aminobutyric Acid; Gene Expression; Humans; Hypnotics and Sedatives; Patch-Clamp Techniques; Propofol; Receptors, GABA-A; Recombinant Proteins; Transfection | 2009 |
Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats.
Topics: Affect; Aggression; Animals; Anxiety; Appetitive Behavior; Desoxycorticosterone; Estradiol; Estrogens; Exploratory Behavior; Female; Microinjections; Neurosecretory Systems; Ovariectomy; Posture; Radioimmunoassay; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Steroids; Ventral Tegmental Area | 2008 |
Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control.
Topics: Anesthetics; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Desoxycorticosterone; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Female; GABA Agents; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Rats; Sodium Channel Blockers; Strychnine; Tetrodotoxin | 2008 |
Unanticipated structural and functional properties of delta-subunit-containing GABAA receptors.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; GABA Agents; GABA Agonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gene Expression; Humans; Oocytes; Protein Structure, Quaternary; Receptors, GABA-A; Recombinant Fusion Proteins; Structure-Activity Relationship; Xenopus; Zinc | 2009 |
Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.
Topics: Analgesics; Animals; Behavior, Animal; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Antagonists; Immunohistochemistry; Injections, Spinal; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Pain; Peripheral Nervous System Diseases; Pregnanolone; Progesterone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Spinal Nerves | 2009 |
Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions.
Topics: Adenosine Triphosphate; Animals; Cell Line; Desoxycorticosterone; Drug Interactions; Estradiol; Female; Genomics; Humans; Ion Channel Gating; Neurotransmitter Agents; Oocytes; Pregnanediones; Pregnanolone; Progesterone; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Xenopus laevis | 2009 |
Infusions of bicuculline to the ventral tegmental area attenuates sexual, exploratory, and anti-anxiety behavior of proestrous rats.
Topics: Animals; Anxiety; Bicuculline; Consummatory Behavior; Desoxycorticosterone; Estrous Cycle; Exploratory Behavior; Female; GABA Antagonists; Hormones; Interpersonal Relations; Microinjections; Motor Activity; Neurosecretory Systems; Posture; Rats; Rats, Long-Evans; Receptors, GABA-A; Sexual Behavior, Animal; Stereotaxic Techniques; Ventral Tegmental Area | 2009 |
Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.
Topics: Animals; Anti-Anxiety Agents; Biophysical Phenomena; Central Nervous System Depressants; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; GABA Agonists; gamma-Aminobutyric Acid; Isoxazoles; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Transfection; Xenopus | 2009 |
Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
Topics: Adult; Androstane-3,17-diol; Androsterone; Animals; Central Nervous System Depressants; Desoxycorticosterone; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Young Adult | 2010 |
Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Anxiety Agents; Bicuculline; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Desoxycorticosterone; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Agents; Homeostasis; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Patch-Clamp Techniques; Potassium Channels; Protein Subunits; Pyramidal Cells; Pyridazines; Pyrimidines; Receptors, GABA-A; Sodium Channel Blockers; Synapses; Tetrodotoxin; Up-Regulation; Valine | 2010 |
Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans Proteins; Desoxycorticosterone; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Ion Channel Gating; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Pregnenolone; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A | 2010 |
Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission.
Topics: Action Potentials; Animals; Bicuculline; Desoxycorticosterone; Electric Stimulation; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Spinal Nerves; Synaptic Transmission; Time Factors; Urethra | 2010 |
Mnemonic effects of progesterone to mice require formation of 3alpha,5alpha-THP.
Topics: Animals; Binding, Competitive; Brain; Cerebral Cortex; Cognition; Desoxycorticosterone; Estrous Cycle; Female; Hippocampus; Memory; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Progesterone; Progestins; Receptors, Progesterone | 2010 |
Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats.
Topics: 20-alpha-Dihydroprogesterone; Animals; Anxiety; Behavior, Animal; Desoxycorticosterone; Disease Models, Animal; Drug Therapy, Combination; Estrogens, Conjugated (USP); Female; Hippocampus; Maze Learning; Medroxyprogesterone Acetate; Progesterone; Rats; Rats, Long-Evans | 2010 |
Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABA(A) receptor by a neurosteroid (3alpha, 21-dihydroxy-5alpha-pregnan-20-one): transient kinetic investigations.
Topics: Cells, Cultured; Desoxycorticosterone; Epilepsy; Humans; Kinetics; Mutation; Neurotransmitter Agents; Photolysis; Receptors, GABA-A; Transfection | 2010 |
Differential effects of two major neurosteroids on cerebellar and cortical GABA(A) receptor binding and function.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Furosemide; GABA-A Receptor Agonists; Gene Knockout Techniques; Male; Mice; Neurotransmitter Agents; Pregnanolone; Protein Binding; Rats; Receptors, GABA-A | 2011 |
Kindling alters neurosteroid-induced modulation of phasic and tonic GABAA receptor-mediated currents: role of phosphorylation.
Topics: Animals; Cerebral Cortex; Desoxycorticosterone; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Indoles; Inhibitory Postsynaptic Potentials; Kindling, Neurologic; Male; Maleimides; Neurotransmitter Agents; Patch-Clamp Techniques; Phorbol Esters; Phosphorylation; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA | 2011 |
Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-alpha Reductase Inhibitors; Animals; Behavior, Animal; Brain; Brain Chemistry; Cholestenone 5 alpha-Reductase; Desoxycorticosterone; Dopamine; Finasteride; Male; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Social Isolation | 2011 |
Pharmacological enhancement of δ-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice.
Topics: Action Potentials; Analgesics; Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Formaldehyde; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hindlimb Suspension; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Pain Measurement; Psychomotor Performance; Receptors, GABA-A; Sensory Receptor Cells; Spinal Cord | 2011 |
Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons.
Topics: Animals; Benzodiazepines; Desoxycorticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Postsynaptic Potentials; Male; Models, Animal; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Supraoptic Nucleus | 2011 |
Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors.
Topics: 5-alpha Reductase Inhibitors; Animals; Behavior, Animal; Corticotropin-Releasing Hormone; Desoxycorticosterone; Finasteride; Hypothalamo-Hypophyseal System; Hypothalamus; Male; Mice; Mice, Transgenic; Neurons; Neurotransmitter Agents; Pituitary-Adrenal System; Receptors, GABA-A; Stress, Physiological | 2011 |
Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease.
Topics: Aged; Aldosterone; Biomarkers; Cross-Sectional Studies; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Hypertrophy, Left Ventricular; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Proteinuria; Renal Insufficiency, Chronic; Sex Factors | 2012 |
Layer- and cell-type-specific tonic GABAergic inhibition of pyramidal neurons in the rat visual cortex.
Topics: Animals; Desoxycorticosterone; Female; gamma-Aminobutyric Acid; Male; Neurons; Pyramidal Cells; Rats; Receptors, GABA-A; Visual Cortex | 2013 |
Neurosteroids modulate epileptiform activity and associated high-frequency oscillations in the piriform cortex.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Biophysics; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Neurotransmitter Agents; Piperazines; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley | 2014 |
Modulation of the human ρ1 GABAA receptor by inhibitory steroids.
Topics: Animals; Desoxycorticosterone; Estradiol; Female; GABA Antagonists; Humans; Mutation; Neurotransmitter Agents; Oocytes; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Xenopus laevis | 2014 |
Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala.
Topics: Amygdala; Animals; Desoxycorticosterone; Diazepam; GABA Modulators; Inhibitory Postsynaptic Potentials; Interneurons; Isoxazoles; Mice; Neural Inhibition; Receptors, GABA-A | 2014 |
Synaptic GABAA receptor clustering without the γ2 subunit.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Convulsants; Desoxycorticosterone; Electric Stimulation; Female; Flurazepam; GABA Agents; Green Fluorescent Proteins; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lysine; Male; Membrane Potentials; Mice; Mice, Transgenic; Neocortex; Neurons; Receptors, GABA-A; Synapses | 2014 |
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors.
Topics: Animals; Blotting, Western; Desoxycorticosterone; HEK293 Cells; Humans; Mice; Neural Inhibition; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptors, GABA-A; Staurosporine; Synapses; Transfection | 2015 |
Corticosterone and corticotropin-releasing factor acutely facilitate gamma oscillations in the hippocampus in vitro.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Corticosterone; Corticotropin-Releasing Hormone; Desoxycorticosterone; Dose-Response Relationship, Drug; Gamma Rhythm; Hippocampus; Male; Neurotransmitter Agents; Physostigmine; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Time Factors; Tissue Culture Techniques | 2015 |
Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons.
Topics: Animals; Blood Chemical Analysis; Corticosterone; Desoxycorticosterone; gamma-Aminobutyric Acid; Microelectrodes; Neural Inhibition; Nociceptive Pain; Pain Measurement; Patch-Clamp Techniques; Physical Stimulation; Posterior Horn Cells; Radioimmunoassay; Rats; Receptors, GABA-A; Synaptic Transmission; Tissue Culture Techniques | 2015 |
Neurosteroids differentially modulate fast and slow interictal discharges in the hippocampal CA3 area.
Topics: 4-Aminopyridine; Animals; CA3 Region, Hippocampal; Desoxycorticosterone; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Male; Microelectrodes; Neurotransmitter Agents; Periodicity; Potassium Channel Blockers; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glutamate; Tissue Culture Techniques | 2015 |
Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Desoxycorticosterone; Entorhinal Cortex; Epilepsy; In Vitro Techniques; Male; Pilocarpine; Piriform Cortex; Rats; Rats, Sprague-Dawley | 2015 |
Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.
Topics: Animals; Cations, Divalent; Copper; Desoxycorticosterone; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mice; Oocytes; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Xenopus laevis; Zinc | 2015 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; GABA Modulators; Male; Metyrapone; Motivation; Oxazepam; Pregnanolone; Rats, Wistar; Self Administration | 2015 |
GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
Topics: Animals; Circadian Rhythm; Desoxycorticosterone; Drug Antagonism; HEK293 Cells; Hepatic Encephalopathy; Humans; Hydroxysteroids; Hyperammonemia; Locomotion; Male; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2015 |
Enduring changes in tonic GABAA receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice.
Topics: Anesthetics; Animals; Brain Injuries; Cerebral Cortex; Dentate Gyrus; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Functional Laterality; GABA Agonists; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Isoxazoles; Male; Mice; Neurons; Receptors, GABA-A; RNA, Messenger; Signal Transduction | 2016 |
Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.
Topics: Desoxycorticosterone; Glycine; HEK293 Cells; Humans; Hyperekplexia; Models, Molecular; Mutation, Missense; Picrotoxin; Pregnenolone; Receptors, Glycine; Zinc | 2016 |
Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
Topics: Animals; Benzamides; Desoxycorticosterone; gamma-Aminobutyric Acid; Imidazoles; Rats; Receptors, GABA-A; Xenopus | 2016 |
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Cyanobacteria; Desoxycorticosterone; Hydroxylation; Kinetics; Ligand-Gated Ion Channels; Ligands; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Mutagenesis, Site-Directed; Neurotransmitter Agents; Photoaffinity Labels; Point Mutation; Pregnanes; Protein Conformation; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Multimerization; Recombinant Proteins | 2018 |
Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala.
Topics: Adrenergic alpha-1 Receptor Antagonists; Amygdala; Animals; Desoxycorticosterone; Fear; gamma-Aminobutyric Acid; Ion Channel Gating; Male; Memory; Mice, Inbred C57BL; Neural Inhibition; Neurons; Neurotransmitter Agents; Nicotine; Norepinephrine; Presynaptic Terminals; Serotonin | 2018 |
Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models.
Topics: Animals; Brain; Desoxycorticosterone; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Male; Pregnanolone; Rats; Rats, Wistar | 2018 |
Analysis of Modulation of the
Topics: Animals; Animals, Genetically Modified; Binding Sites; Desoxycorticosterone; Drug Synergism; Drug Therapy, Combination; Humans; Models, Molecular; Molecular Structure; Neurosteroids; Pregnanolone; Receptors, GABA-A; Xenopus laevis | 2020 |
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry | 2020 |