Page last updated: 2024-08-16

tetraethylammonium and cimetidine

tetraethylammonium has been researched along with cimetidine in 68 studies

Research

Studies (68)

TimeframeStudies, this research(%)All Research%
pre-19904 (5.88)18.7374
1990's24 (35.29)18.2507
2000's31 (45.59)29.6817
2010's8 (11.76)24.3611
2020's1 (1.47)2.80

Authors

AuthorsStudies
Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L1
Babbitt, PC; Chun, JK; Dresser, MJ; Giacomini, KM; Zhang, L1
Inui, KI; Ito, T; Tanaka, K; Yano, I1
Fei, YJ; Ganapathy, V; Kekuda, R; Leibach, FH; Prasad, PD; Wang, H; Wu, X1
Giacomini, KM; Schaner, ME; Zhang, L1
Inui, KI; Masuda, S; Okuda, M; Saito, H; Urakami, Y1
Inui, K; Okuda, M; Saito, H; Urakami, Y1
Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H1
Chen, R; Nelson, JA; Pan, BF; Pritchard, JB; Sweet, DH1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N1
Gründemann, D; Kiefer, N; Köster, S; Liebich, G; Schömig, E1
Chen, J; Conway, SJ; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Rajan, DP; Seth, P; Wu, X1
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H1
Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X1
Conway, SJ; Ganapathy, ME; Ganapathy, V; Huang, W; Kekuda, R; Leibach, FH; Wang, H; Wu, X1
Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T1
Buitelaar, M; Jonker, JW; Koepsell, H; Mol, CA; Schinkel, AH; Smit, JW; Wagenaar, E1
Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y1
Kakehi, M; Koyabu, N; Kuwano, M; Nakamura, T; Ohtani, H; Sawada, Y; Uchiumi, T1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Dutt, A; Kuo, MT; Nelson, JA; Priebe, TS; Teeter, LD1
Hirai, M; Hori, R; Kaneko, S; Katsura, T; Satoh, M; Takano, M; Yasuhara, M1
Brink, C; Gorenne, I; Labat, C; Norel, X; Ortiz, JL; Verley, J1
Haseley, TS; Hosford, M; Lesniak, ME; McKinney, TD; Scheller, MB1
Brändle, E; Greven, J1
DeLeon, C; McKinney, TD; Speeg, KV1
Hanano, M; Iga, T; Sawada, Y; Sugiyama, Y; Suzuki, H1
Herbert, BH; Nelson, JA; Santos, G1
Cacini, W; Grund, VR; Keller, MB1
Bendayan, R; Lo, B; Silverman, M1
Gross, AS; Simmons, N; Somogyi, AA1
Hori, R; Inui, K; Katsura, T; Takano, M; Tomita, Y; Yasuhara, M1
Inui, K; Okuda, M; Saito, H; Takano, M; Urakami, Y1
Bendayan, R1
Hashimoto, Y; Inui, K; Ito, T; Masuda, S; Yano, I1
Hashimoto, Y; Inui, K; Ito, T; Yano, I1
Aavula, BR; Bednarczyk, D; Mash, EA; Wright, SH1
Hagen, SJ; Morrison, SW; Wu, H1
Duggin, GG; Lazzaro, V; Machaalani, R1
Fukada, A; Inui, KI; Ohnishi, S; Saito, H1
Doi, Y; Hasegawa, T; Kitaichi, K; Matsushima, M; Morishita, Y; Takagi, K; Ueyama, J; Zhao, YL1
Chatsudthipong, V; Dantzler, WH; Evans, KK; Kaewmokul, S; Wright, SH1
O'Donnell, MJ; Rheault, MR1
Dohgu, S; Higuchi, S; Katamine, S; Kataoka, Y; Naito, M; Niwa, M; Sawada, Y; Shirabe, S; Takata, F; Tsuruo, T; Yamauchi, A1
Endou, H; Hirono, S; Kusuhara, H; Nagata, Y; Sugiyama, Y1
Inui, K; Katsura, T; Kimura, N; Masuda, S; Okuda, M; Urakami, Y1
Bijelic, G; Kim, NR; O'Donnell, MJ1
O'Donnell, MJ; Plaumann, JS; Rheault, MR1
Hayashi, Y; Inoue, K; Ohta, KY; Yuasa, H1
Cherrington, NJ; Wright, SH; Zhang, X1
Iwatsubo, T; Kamimura, H; Noguchi, K; Umehara, KI2
Abe, F; Hasegawa, T; Kato, M; Kimura, M; Kurono, S; Nadai, M; Saito, H; Yoshizumi, H1
Inui, K; Katsura, T; Masuda, S; Sato, T; Tanihara, Y; Yonezawa, A1
Rodriguez-Proteau, R; Taur, JS1
Hashimoto, Y; Kagawa, Y; Taguchi, M; Tahara, K; Takaai, M1
Hayashi, M; Kishimoto, H; Takizawa, Y; Tomita, M1
Inoue, K; Ishimaru, M; Ohta, KY; Yasujima, T; Yuasa, H1
Inoue, K; Ito, S; Kusuhara, H; Sugiyama, Y; Toyoshima, J; Yokochi, M; Yuasa, H1
Harper, JN; Wright, SH1
Al-Monajjed, R; Ciarimboli, G; Gorboulev, V; Keller, T; Koepsell, H; Lee, WK; Leistner, M; Schatz, I; Thévenod, F; Wolff, NA1
Chen, J; Chen, X; Li, J; Li, X; Lu, Y; Sun, X; Wang, C; Zhang, Q; Zhang, Y; Zhao, D1
Kaddoumi, A; Mohamed, LA1
Goda, M; Ikehara, M; Ishizawa, K; Oda, K; Otsuka, M; Sakitani, M1

Reviews

1 review(s) available for tetraethylammonium and cimetidine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

67 other study(ies) available for tetraethylammonium and cimetidine

ArticleYear
Cloning and functional expression of a human liver organic cation transporter.
    Molecular pharmacology, 1997, Volume: 51, Issue:6

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis

1997
Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).
    The Journal of biological chemistry, 1997, Jun-27, Volume: 272, Issue:26

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; Kidney; Membrane Proteins; Molecular Sequence Data; Organic Cation Transporter 1; Protein Biosynthesis; Rats; RNA, Messenger; Tetraethylammonium Compounds; Xenopus laevis

1997
Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Anti-Infective Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Daunorubicin; Epithelial Cells; Epithelium; Fluoroquinolones; Humans; Kidney; Levofloxacin; LLC-PK1 Cells; Ofloxacin; Quinolones; Swine

1997
Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta.
    The Journal of biological chemistry, 1998, Jun-26, Volume: 273, Issue:26

    Topics: Amino Acid Sequence; Animals; Cloning, Molecular; DNA-Binding Proteins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Octamer Transcription Factor-3; Oocytes; Placenta; Protein Conformation; Rats; Transcription Factors; Xenopus laevis

1998
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection

1998
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Animals; Base Sequence; Carrier Proteins; Cations; Cell Line; Cell Membrane; DNA Primers; Dogs; Kidney Tubules; Membrane Proteins; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Tetraethylammonium

1998
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes.
    Biochimica et biophysica acta, 1999, Mar-04, Volume: 1417, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Buffers; Carrier Proteins; Cells, Cultured; Hydrogen-Ion Concentration; Levofloxacin; Membrane Proteins; Ofloxacin; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Potassium; Rats; Tetraethylammonium; Transfection; Xenopus laevis

1999
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis

1999
A transfected cell model for the renal toxin transporter, rOCT2.
    Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 47, Issue:2

    Topics: 3T3 Cells; Animals; Antineoplastic Agents; Carrier Proteins; Cisplatin; Daunorubicin; Deoxyadenosines; DNA, Complementary; Kidney; Kinetics; Mice; Models, Genetic; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tetraethylammonium Compounds; Transfection; Vinblastine

1999
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain.
    The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19

    Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis

1999
Selective substrates for non-neuronal monoamine transporters.
    Molecular pharmacology, 1999, Volume: 56, Issue:1

    Topics: Amino Acid Sequence; Animals; Biological Transport; Carrier Proteins; Cells, Cultured; DNA, Complementary; Guanidine; Histamine; Humans; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Neuropeptides; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Sequence Homology, Amino Acid; Vesicular Biogenic Amine Transport Proteins

1999
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Acetylcarnitine; Animals; Biological Transport, Active; Carnitine; Carrier Proteins; Humans; In Situ Hybridization; Kidney; Membrane Proteins; Mice; Myocardium; Organ Specificity; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium

1999
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism

1999
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
    Biochimica et biophysica acta, 2000, Jun-01, Volume: 1466, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution

2000
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
    American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Binding, Competitive; Carbon Radioisotopes; Cations; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dopamine Agents; Exons; Gene Expression Regulation; HeLa Cells; Herbicides; Humans; In Situ Hybridization; Introns; Kidney; Mice; Niacinamide; Octamer Transcription Factor-3; Oocytes; Pigment Epithelium of Eye; RNA, Messenger; Tetraethylammonium; Transcription Factors; Tritium; Xenopus laevis

2000
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 11, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil

2000
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
    Molecular pharmacology, 2001, Volume: 59, Issue:5

    Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis

2001
Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.
    Molecular and cellular biology, 2001, Volume: 21, Issue:16

    Topics: Animals; Carrier Proteins; Cations; Intestinal Mucosa; Ion Transport; Liver; Membrane Proteins; Mice; Mice, Knockout; Organic Cation Transporter 1

2001
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:7

    Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection

2002
Functional characterization of mouse cation transporter mOCT2 compared with mOCT1.
    Biochemical and biophysical research communications, 2002, Aug-23, Volume: 296, Issue:3

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Base Sequence; Biological Transport; Cations; Cells, Cultured; Cloning, Molecular; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Mice; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Tetraethylammonium; Xenopus

2002
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Postnatal development of organic cation transport and mdr gene expression in mouse kidney.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:3

    Topics: Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cimetidine; Culture Techniques; Gene Expression; Kidney; Liver; Membrane Glycoproteins; Mice; Niacinamide; Tetraethylammonium; Tetraethylammonium Compounds

1992
Expression of renal organic cation transporter in Xenopus laevis oocytes.
    The Biochemical journal, 1992, Apr-15, Volume: 283 ( Pt 2)

    Topics: Animals; Carrier Proteins; Cimetidine; Gene Expression; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Male; Mercuric Chloride; Oocytes; p-Aminohippuric Acid; Poly A; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Tetraethylammonium; Tetraethylammonium Compounds; Xenopus laevis

1992
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Pulmonary Artery; Receptors, Histamine; Serotonin; Tetraethylammonium; Tetraethylammonium Compounds; Thiourea

1992
Basolateral transport of tetraethylammonium by a clone of LLC-PK1 cells.
    Journal of the American Society of Nephrology : JASN, 1992, Volume: 2, Issue:10

    Topics: Animals; Basement Membrane; Biological Transport, Active; Cimetidine; Clone Cells; Kidney; Kinetics; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil

1992
Transport of cimetidine across the basolateral membrane of rabbit kidney proximal tubules: characterization of transport mechanisms.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:3

    Topics: Animals; Basement Membrane; Biological Transport; Chlorides; Cimetidine; Female; Hydrogen-Ion Concentration; Intracellular Fluid; Kidney Tubules, Proximal; Male; Membrane Potentials; Niacinamide; Osmolar Concentration; Potassium; Quinine; Rabbits; Tetraethylammonium; Tetraethylammonium Compounds

1991
Organic cation uptake by a cultured renal epithelium.
    Journal of cellular physiology, 1988, Volume: 137, Issue:3

    Topics: Animals; Azides; Biological Transport; Cell Line; Cimetidine; Epithelial Cells; Epithelium; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Kinetics; Quinidine; Sodium Azide; Temperature; Tetraethylammonium; Tetraethylammonium Compounds

1988
Comparative uptake of cimetidine by rat choroid plexus between the lateral and the 4th ventricles.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:3

    Topics: Animals; Cerebral Ventricles; Choroid Plexus; Cimetidine; In Vitro Techniques; Kinetics; Male; Penicillin G; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds

1986
Mechanisms for the renal secretion of cisplatin.
    Cancer treatment reports, 1984, Volume: 68, Issue:6

    Topics: Animals; Binding, Competitive; Biological Transport, Active; Cimetidine; Cisplatin; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred AKR; p-Aminohippuric Acid; Platinum; Probenecid; Tetraethylammonium; Tetraethylammonium Compounds

1984
Accumulation of cimetidine by kidney cortex slices.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:2

    Topics: Animals; Cimetidine; Dogs; Energy Metabolism; Guanidines; In Vitro Techniques; Kidney Cortex; Male; p-Aminohippuric Acid; Probenecid; Quinine; Quinolinium Compounds; Sodium Cyanide; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors

1982
Characterization of cimetidine transport in LLCPK1 cells.
    Journal of the American Society of Nephrology : JASN, 1994, Volume: 5, Issue:1

    Topics: Amiloride; Animals; Anti-Bacterial Agents; Azides; Biological Transport; Carrier Proteins; Cell Line; Cimetidine; Guanidine; Guanidines; Kidney; Macrolides; Microscopy, Fluorescence; Models, Biological; Niacinamide; Proton-Translocating ATPases; Quinidine; Quinine; Sodium Azide; Sodium-Hydrogen Exchangers; Swine; Tetraethylammonium; Tetraethylammonium Compounds

1994
In-vitro potencies of histamine H2-receptor antagonists on tetraethylammonium uptake in rat renal brush-border membrane vesicles.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:5

    Topics: Alkaline Phosphatase; Animals; Cimetidine; Famotidine; In Vitro Techniques; Kidney; Male; Microvilli; Ranitidine; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds

1994
Characteristics of organic cation transporter in rat renal basolateral membrane.
    Biochimica et biophysica acta, 1993, Mar-14, Volume: 1146, Issue:2

    Topics: Amiloride; Animals; Carrier Proteins; Cations; Cell Membrane; Cimetidine; Ion Transport; Kidney Cortex; Male; Mercuric Chloride; Microvilli; Phenylglyoxal; Procainamide; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds

1993
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.
    Biochemical and biophysical research communications, 1996, Jul-16, Volume: 224, Issue:2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Blotting, Northern; Carrier Proteins; Cimetidine; Cloning, Molecular; DNA Primers; DNA, Complementary; Female; In Vitro Techniques; Kidney; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Polymerase Chain Reaction; Procainamide; Quinidine; Rats; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Tetraethylammonium; Tetraethylammonium Compounds; Xenopus laevis

1996
Interaction of dipyridamole, a nucleoside transport inhibitor, with the renal transport of organic cations by LLCPK1 cells.
    Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:1

    Topics: Animals; Biological Transport; Cell Line; Cimetidine; Dipyridamole; Epithelium; Ions; Kidney; Kinetics; Niacinamide; Swine; Tetraethylammonium; Tetraethylammonium Compounds

1997
Distribution characteristics of levofloxacin and grepafloxacin in rat kidney.
    Pharmaceutical research, 1999, Volume: 16, Issue:4

    Topics: Animals; Anti-Infective Agents; Carbon Radioisotopes; Cimetidine; Dose-Response Relationship, Drug; Fluoroquinolones; In Vitro Techniques; Kidney Cortex; Kinetics; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Tissue Distribution

1999
Transepithelial transport of levofloxacin in the isolated perfused rat kidney.
    Pharmaceutical research, 2000, Volume: 17, Issue:2

    Topics: Animals; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biological Transport; Carbon Radioisotopes; Cimetidine; Coloring Agents; Enzyme Inhibitors; Epithelial Cells; Evans Blue; Fluoroquinolones; In Vitro Techniques; Inulin; Kidney; Levofloxacin; Male; Ofloxacin; p-Aminohippuric Acid; Perfusion; Piperazines; Rats; Rats, Wistar; Tetraethylammonium; Urine

2000
NBD-TMA: a novel fluorescent substrate of the peritubular organic cation transporter of renal proximal tubules.
    Pflugers Archiv : European journal of physiology, 2000, Volume: 440, Issue:1

    Topics: Animals; Biological Transport; Carrier Proteins; Cell Survival; Cimetidine; Diffusion Chambers, Culture; Fluorescence; Fluorescent Dyes; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules, Proximal; Models, Biological; Niacinamide; Quaternary Ammonium Compounds; Rabbits; Reproducibility of Results; Tetraethylammonium

2000
NH(4)Cl inhibition of acid secretion: possible involvement of an apical K(+) channel in bullfrog oxyntic cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:2

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Ammonia; Ammonium Chloride; Animals; Barium; Biological Transport; Bumetanide; Carbachol; Carbon Radioisotopes; Cholinergic Agents; Cimetidine; Clotrimazole; Diuretics; Enzyme Inhibitors; Gastric Mucosa; Growth Inhibitors; Histamine; Hydrochloric Acid; Hypoglycemic Agents; Imidazoles; Methylamines; Microscopy, Electron; Omeprazole; Ouabain; Parietal Cells, Gastric; Potassium Channel Blockers; Potassium Channels; Protons; Rana catesbeiana; Tetraethylammonium; Tolbutamide

2000
The characterisation and uptake of paraquat in cultured baboon kidney proximal tubule cells (bPTC).
    Human & experimental toxicology, 2001, Volume: 20, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Biological Transport; Cations; Cell Line; Cells, Cultured; Cimetidine; Dogs; Herbicides; Kidney Tubules, Distal; Kidney Tubules, Proximal; Papio; Paraquat; Swine; Tetraethylammonium

2001
Independent organic cation transport activity of Na(+)-L-carnitine cotransport system in LLC-PK(1) cells.
    American journal of physiology. Renal physiology, 2001, Volume: 281, Issue:2

    Topics: Animals; Carnitine; Carrier Proteins; Cations; Cell Line; Cell Polarity; Cephaloridine; Cephalosporins; Cimetidine; Enzyme Inhibitors; Epithelial Cells; Hydrogen-Ion Concentration; Ion Transport; Kidney Tubules, Proximal; Kinetics; Quinidine; Sodium; Swine; Tetraethylammonium

2001
Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats.
    European journal of pharmacology, 2003, Mar-07, Volume: 464, Issue:1

    Topics: Animals; Area Under Curve; Behavior, Animal; Brain; Carnitine; Carrier Proteins; Central Nervous System Stimulants; Cimetidine; Dialysis Solutions; Gene Expression Regulation; Kidney; Male; Membrane Proteins; Metabolic Clearance Rate; Methamphetamine; Motor Activity; Myocardium; Organic Cation Transport Proteins; p-Aminohippuric Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Solute Carrier Family 22 Member 5; Tetraethylammonium; Time Factors; Tissue Distribution

2003
Functional mapping of rbOCT1 and rbOCT2 activity in the S2 segment of rabbit proximal tubule.
    American journal of physiology. Renal physiology, 2003, Volume: 285, Issue:6

    Topics: Animals; CHO Cells; Cimetidine; COS Cells; Cricetinae; Enzyme Inhibitors; Gene Expression; Kidney Tubules, Proximal; Organic Cation Transport Proteins; Organic Cation Transporter 1; Potassium Channel Blockers; Rabbits; RNA, Messenger; Tetraethylammonium; Tritium

2003
Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 12

    Topics: Animals; Biological Transport, Active; Cimetidine; Drosophila melanogaster; Electrophysiology; Ion Transport; Malpighian Tubules; Microelectrodes; Potassium; Quinidine; Tetraethylammonium; Tetraphenylborate; Verapamil; Vinblastine

2004
Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier.
    Cellular and molecular neurobiology, 2004, Volume: 24, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cation Transport Proteins; Cell Line; Cell Membrane; Cell Polarity; Cimetidine; Cyclosporine; Endothelial Cells; Fluorescein; Membrane Potentials; Mice; Prion Diseases; Quinacrine; Tetraethylammonium; Verapamil

2004
Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3.
    Drug metabolism and disposition: the biological fate of chemicals, 2004, Volume: 32, Issue:9

    Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cerebrospinal Fluid; Choroid Plexus; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Male; Models, Molecular; Molecular Structure; Organic Cation Transport Proteins; Penicillin G; Probenecid; Ranitidine; Rats; Rats, Sprague-Dawley; Static Electricity; Tetraethylammonium; Tritium

2004
Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1.
    Drug metabolism and pharmacokinetics, 2005, Volume: 20, Issue:3

    Topics: Animals; Anions; Biological Transport; Cations; Cimetidine; Creatinine; Kidney Tubules; LLC-PK1 Cells; Membrane Potentials; Swine; Tetraethylammonium; Trimethoprim

2005
Effects of dietary or injected organic cations on larval Drosophila melanogaster: mortality and elimination of tetraethylammonium from the hemolymph.
    Archives of insect biochemistry and physiology, 2005, Volume: 60, Issue:2

    Topics: Animals; Biological Transport, Active; Cations; Cimetidine; Diet; Dose-Response Relationship, Drug; Drosophila melanogaster; Hemolymph; Larva; Lethal Dose 50; Malpighian Tubules; Quinidine; Survival Rate; Temperature; Tetraethylammonium

2005
Tetraethylammonium and nicotine transport by the Malpighian tubules of insects.
    Journal of insect physiology, 2006, Volume: 52, Issue:5

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, Thin Layer; Cimetidine; Female; In Vitro Techniques; Insecta; Male; Malpighian Tubules; Niacinamide; Nicotine; Quinidine; Rhodnius; Tetraethylammonium; Time Factors

2006
Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:11

    Topics: Animals; Antiporters; Biological Transport; Blotting, Northern; Cations; Cell Line; Cimetidine; Cloning, Molecular; Humans; Hydrogen-Ion Concentration; Kidney; Organic Cation Transport Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA; Substrate Specificity; Tetraethylammonium; Transfection

2006
Molecular identification and functional characterization of rabbit MATE1 and MATE2-K.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Algorithms; Amino Acid Sequence; Animals; Biological Transport, Active; CHO Cells; Cimetidine; Cloning, Molecular; Cricetinae; Cricetulus; Dopamine Agents; Histamine H2 Antagonists; Hydrogen-Ion Concentration; Microvilli; Molecular Sequence Data; Organic Cation Transport Proteins; Protein Structure, Secondary; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Substrate Specificity; Tetraethylammonium; Transfection

2007
Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:6

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Biguanides; Cell Line; Cimetidine; Drug Design; Famotidine; Histamine H2 Antagonists; Humans; Ion Transport; Kinetics; Metformin; Organic Cation Transport Proteins; Phenformin; Ranitidine; Rats; Tetraethylammonium

2007
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2007, Volume: 37, Issue:8

    Topics: Animals; Carbon Radioisotopes; Cell Line; Cimetidine; Cryopreservation; DNA, Complementary; Hepatocytes; Humans; Metformin; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 1; Pyridinium Compounds; Rats; Tetraethylammonium; Transfection; Tritium

2007
Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.
    Life sciences, 2007, Sep-22, Volume: 81, Issue:15

    Topics: Animals; Cimetidine; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Organic Anion Transporters; Organic Cation Transport Proteins; p-Aminohippuric Acid; Probenecid; Rats; Rats, Wistar; Substrate Specificity; Tetraethylammonium; Time Factors; Xanthines

2007
Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.
    Biochemical pharmacology, 2008, Oct-01, Volume: 76, Issue:7

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Cimetidine; Dogs; Humans; Metformin; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Procainamide; Quinidine; Tetraethylammonium; Transfection

2008
Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models.
    Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cimetidine; Flavanones; Flavonoids; Genistein; Humans; LLC-PK1 Cells; Organic Cation Transport Proteins; Propiophenones; Quercetin; Swine; Tetraethylammonium

2008
Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 Cells.
    Drug metabolism and pharmacokinetics, 2008, Volume: 23, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bisoprolol; Cells, Cultured; Cimetidine; LLC-PK1 Cells; Organic Cation Transport Proteins; Quinidine; Swine; Tetraethylammonium

2008
Effects of intestinal ischemia/reperfusion on P-glycoprotein mediated biliary and renal excretion of rhodamine123 in rat.
    Drug metabolism and pharmacokinetics, 2009, Volume: 24, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biliary Tract; Cimetidine; Cyclosporine; Kidney; Liver; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reperfusion Injury; Rhodamine 123; Tetraethylammonium; Verapamil

2009
Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2009, Volume: 12, Issue:3

    Topics: Animals; Antiporters; Cell Line, Tumor; Cimetidine; DNA, Complementary; Enzyme Inhibitors; Humans; Kidney; Kinetics; Organic Cation Transport Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Tetraethylammonium; Transfection

2009
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; 3-Iodobenzylguanidine; Animals; Binding, Competitive; Biological Transport; Cephalexin; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; HEK293 Cells; Humans; Kidney; Kinetics; Liver; Male; Metformin; Mice; Mice, Inbred Strains; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Pyridines; Tetraethylammonium; Transfection

2012
Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2.
    American journal of physiology. Renal physiology, 2013, Jan-01, Volume: 304, Issue:1

    Topics: 1-Methyl-4-phenylpyridinium; Androstenes; Animals; Benzhydryl Compounds; Carbazoles; Carvedilol; CHO Cells; Cimetidine; Cricetinae; Cricetulus; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperidines; Propanolamines; Tetraethylammonium

2013
Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.
    Molecular pharmaceutics, 2013, Aug-05, Volume: 10, Issue:8

    Topics: Animals; Apoptosis; Cadmium; Catecholamine Plasma Membrane Transport Proteins; Cell Line; Cimetidine; Corticosterone; Humans; Kidney Tubules, Proximal; Organic Cation Transport Proteins; Organic Cation Transporter 2; Rats; Tetraethylammonium

2013
Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cimetidine; Guanfacine; HEK293 Cells; Humans; Kidney; Male; Organic Cation Transport Proteins; Organic Cation Transporter 2; Random Allocation; Rats, Sprague-Dawley; Tetraethylammonium

2015
Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2014, Volume: 17, Issue:3

    Topics: Animals; Cells, Cultured; Cimetidine; Dose-Response Relationship, Drug; Hepatocytes; Male; Rats; Rats, Sprague-Dawley; Tacrine; Tetraethylammonium; Tissue Distribution; Verapamil

2014
Involvement of Human Multidrug and Toxic Compound Extrusion (MATE) Transporters in Testosterone Transport.
    Biological & pharmaceutical bulletin, 2021, Volume: 44, Issue:4

    Topics: Animals; Cimetidine; Estradiol; HEK293 Cells; Humans; LLC-PK1 Cells; Models, Molecular; Organic Cation Transport Proteins; Swine; Testosterone; Tetraethylammonium

2021