Compounds > tetraethylammonium
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tetraethylammonium and amantadine

tetraethylammonium has been researched along with amantadine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's5 (41.67)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giacomini, KM; Schaner, ME; Zhang, L1
Akazawa, M; Inui, K; Okuda, M; Saito, H; Urakami, Y1
Bednarczyk, D; Ekins, S; Wikel, JH; Wright, SH1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Babu, E; Ganapathy, V; Ho, HT; Itagaki, S; Wang, J; Zhou, M1
Bedwell, DW; Higgins, JW; Zamek-Gliszczynski, MJ1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Goralski, KB; Sitar, DS1
Cherrington, NJ; Dantzler, WH; Evans, KK; Sitar, DS; Wright, SH; Zhang, X1
Busath, DD; Chorak, A; Cross, TA; Gao, PF; Vijayvergiya, V; Wilson, R1
Bose, R; Goralski, KB; Sitar, DS1

Reviews

1 review(s) available for tetraethylammonium and amantadine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

11 other study(ies) available for tetraethylammonium and amantadine

ArticleYear
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection

1998
cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
    Journal of the American Society of Nephrology : JASN, 2002, Volume: 13, Issue:7

    Topics: Alternative Splicing; Amino Acid Sequence; Base Sequence; Cations; Cell Line; Cloning, Molecular; DNA, Complementary; Genetic Variation; Humans; Kidney; Molecular Sequence Data; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tetraethylammonium; Tissue Distribution; Transfection

2002
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
    Molecular pharmacology, 2003, Volume: 63, Issue:3

    Topics: Computational Biology; HeLa Cells; Humans; Models, Molecular; Organic Cation Transporter 1; Pyridinium Compounds; Quinolinium Compounds; Structure-Activity Relationship; Transfection

2003
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
Electrophysiological characterization of the polyspecific organic cation transporter plasma membrane monoamine transporter.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:6

    Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Equilibrative Nucleoside Transport Proteins; Female; Humans; Membrane Potentials; Organic Cation Transport Proteins; Xenopus laevis; Xenopus Proteins

2012
Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:6

    Topics: Animals; Kidney; Liver; Male; Metformin; Mice; Mice, Knockout; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; Tissue Distribution

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Tetraethylammonium and amantadine identify distinct organic cation transporters in rat renal cortical proximal and distal tubules.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Amantadine; Animals; Biological Transport, Active; Carrier Proteins; Cations; Kidney Cortex; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Male; Rats; Rats, Sprague-Dawley; Tetraethylammonium

1999
Functional map of TEA transport activity in isolated rabbit renal proximal tubules.
    American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:3

    Topics: Amantadine; Animals; Carbon Radioisotopes; CHO Cells; Cricetinae; Dopamine Agents; Kidney Tubules, Proximal; Models, Biological; Organic Cation Transport Proteins; Organic Cation Transporter 1; Potassium Channel Blockers; Rabbits; RNA, Messenger; Tetraethylammonium; Tritium

2004
Proton conductance of influenza virus M2 protein in planar lipid bilayers.
    Biophysical journal, 2004, Volume: 87, Issue:3

    Topics: Amantadine; Electric Conductivity; Electrophysiology; Hydrochloric Acid; Hydrogen; Hydrogen-Ion Concentration; Ion Channel Gating; Ions; Lipid Bilayers; Lipids; Liposomes; Membrane Potentials; Protons; Sodium; Tetraethylammonium; Viral Matrix Proteins

2004
NH4+ modulates renal tubule amantadine transport independently of intracellular pH changes.
    European journal of pharmacology, 2006, Jul-10, Volume: 541, Issue:1-2

    Topics: Amantadine; Ammonium Chloride; Ammonium Sulfate; Animals; Bicarbonates; Biological Transport; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Proximal; Kinetics; Nitrates; Phosphates; Propionates; Quaternary Ammonium Compounds; Rats; Tetraethylammonium; Time Factors

2006