tetradecanoylphorbol acetate has been researched along with wortmannin in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 92 (55.76) | 18.2507 |
| 2000's | 66 (40.00) | 29.6817 |
| 2010's | 7 (4.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Hazeki, O; Kume, S; Ui, M; Yatomi, Y | 1 |
| Knol, EF; Koenderman, L; Mul, FP; Roos, D; Verhoeven, AJ | 1 |
| Bonser, RW; Garland, LG; Hodson, HF; Randall, RW; Spacey, GD; Tateson, JE; Thompson, NT | 1 |
| McIntyre, TM; Prescott, SM; Reinhold, SL; Zimmerman, GA | 1 |
| Bachelot, C; Cantley, LC; Chen, CS; Falck, JR; Hartwig, JH; Kovacsovics, TJ; Toker, A | 1 |
| Blenis, J; Cheatham, L; Chung, J; Grammer, TC; Lemon, KP; Monfar, M; Vlahos, CJ | 1 |
| Escobedo, JA; Kinashi, T; Springer, TA; Takatsu, K; Williams, LT | 1 |
| Dennis, PB; Han, JW; Pearson, RB; Thomas, G | 1 |
| Bierer, BE; Franklin, DP; Harrison-Findik, D; Hutchcroft, JE; Tsai, B; Varticovski, L | 1 |
| Hawes, BE; Lefkowitz, RJ; Touhara, K; van Biesen, T | 1 |
| Dickson, AJ; Yang, SH | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Kiss, Z; Tomono, M | 2 |
| Bandyopadhyay, G; Farese, RV; Standaert, ML | 1 |
| Hall, A; Hawkins, P; Nobes, CD; Stephens, L | 1 |
| Badwey, JA; Brown, RF; Ding, J; Liu, R; Vlahos, CJ | 1 |
| Granner, DK; O'Brien, RM; Sutherland, C | 1 |
| Foulstone, EJ; Proud, CG; Tavaré, JM; Welsh, GI; Young, SW | 1 |
| Ferby, IM; Kume, K; Sakanaka, C; Shimizu, T; Waga, I | 1 |
| Berton, G; Laudanna, C; Rossi, F | 1 |
| Arcaro, A; Wymann, MP | 1 |
| Gerard, NP; Nicholson-Weller, A; Wang, C | 1 |
| Hirai, S; Kosaka, K; Mizuno, K; Nishioka, N; Ohno, S; Osada, S; Suzuki, A | 1 |
| Chung, T; Kiss, Z | 1 |
| Anel, A; Auphan, N; Boyer, C; Buferne, M; Golstein, P; Schmitt-Verhulst, AM; Simon, AK | 1 |
| Ishizuka, T; Itaya, S; Kajita, K; Nagashima, T; Nozawa, Y; Wada, H; Yamada, K; Yamamoto, M; Yasuda, K | 1 |
| Cunningham, MC; Rittenhouse, SE; Shattil, SJ; Zhang, J | 1 |
| Gingras, AC; Ming, XF; Sonenberg, N; Thomas, G; von Manteuffel, SR | 1 |
| Katsura, Y; Masaki, T; Mazda, O; Miwa, S; Ninomiya, H; Okamoto, Y; Sugawara, F | 1 |
| Le Marchand-Brustel, Y; Ricort, JM; Tanti, JF; Van Obberghen, E | 1 |
| Dong, W; Marin, ML; Murtha, J; Pestka, JJ | 1 |
| Navé, BT; Shepherd, PR; Siddle, K | 1 |
| Sato, SB; Taguchi, T; Toyama, S; Yamashina, S | 1 |
| Abe, H; Obinata, T; Okada, K; Takano-Ohmuro, H | 1 |
| Cook, D; Dale, TC; Fry, MJ; Hughes, K; Sumathipala, R; Woodgett, JR | 1 |
| Chew, CS; Nakamura, K; Parente, J; Zhou, CJ | 1 |
| Araki, N; Johnson, MT; Swanson, JA | 1 |
| Cantley, LC; Hartwig, JH; Janmey, PA; Kovacsovics, T; Kung, S; Stossel, TP; Toker, A | 1 |
| Minokoshi, Y; Shimazu, T; Shimizu, Y; Tanishita, T | 1 |
| Murayama, T; Nomura, Y; Oda, H | 1 |
| Dong, Z; Huang, C; Ma, WY; Schmid, HH; Schmid, PC | 1 |
| Driessens, MH; Roos, E; Soede, RD; van Hulten, PE; van Rijthoven, EA | 1 |
| al-Hassani, M; Natarajan, V; Scribner, WM; Vepa, S | 1 |
| Akerman, KE; Coffey, ET; Courtney, MJ | 1 |
| Earp, HS; Graves, LM; Li, X; Yu, H | 1 |
| Boulougouris, G; Parry, RV; Sansom, DM; Ward, SG | 1 |
| Butler, J; Downey, GP; Fialkow, L; Grinstein, S; Schelm, JA; Sue-A-Quan, AK; Vlahos, CJ | 1 |
| Engleman, EG; Rivas, A; Soares, LR; Tsavaler, L | 1 |
| Bragado, MJ; Groblewski, GE; Williams, JA | 2 |
| Katagiri, Y; Nakamura, M; Nakashima, S; Nozawa, Y | 1 |
| Fukuda, K; Kato, S; Mori, K; Morikawa, H; Shoda, T | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Schläpfer, I; Schmid, C; Veldman, CM | 1 |
| Albrightson, CR; Chirivella, M; DeWolf, RE; Fredrickson, T; King, C; Laping, NJ; Nambi, P; Olson, BA; Ziyadeh, FN | 1 |
| Conus, NM; Hemmings, BA; Pearson, RB | 1 |
| Capodici, C; Feoktistov, M; Hanft, S; Pillinger, MH | 1 |
| Bhattacharyya, SP; Drucker, I; Kirshenbaum, AS; Mekori, YA; Metcalfe, DD; Reshef, T | 1 |
| Akaike, T; Liang, JF | 1 |
| Bannerman, PG; Correale, DM; Davis, KE; Robinson, MB; Rothstein, JD; Straff, DJ; Weinstein, EA | 1 |
| de Jonge, HR; Dorrestijn, J; Maassen, JA; Narumiya, S; Tilly, BC; van der Wijk, T | 1 |
| Chou, CK; Lin, YL | 1 |
| Banfić, H; Rittenhouse, SE; Straforini, F; Tosi, L; Volinia, S; Zhang, J | 1 |
| Fonnum, F; Voie, OA; Wiik, P | 1 |
| Barro, C; Berthier, S; Gaudin, P; Morel, F; Trocmé, C; Zaoui, P | 1 |
| Goldberg, Y; Piper, HM; Schlüter, KD; Taimor, G | 1 |
| Katsuki, H; Matsuki, N; Saito, H; Shitaka, Y | 1 |
| Kiuchi, Y; Oguchi, K; Ohno, M; Uchida, J; Yura, A | 1 |
| Boulay, F; Christophe, T; Milcent, MD; Rabiet, MJ; Tardif, M | 1 |
| Arai, H; Horiuchi, H; Kita, T; Nishioka, H | 1 |
| Hazeki, K; Hazeki, O; Kodama, T; Okada, T; Ui, M | 1 |
| Chen, BC; Lin, WW | 1 |
| Blank, U; David, B; Guérin-Marchand, C; Iannascoli, B; Marchand, F; Pelletier, C; Weyer, A | 1 |
| Lan, L; Wong, NS | 1 |
| Asaoka, T; Kinashi, T; Setoguchi, R; Takatsu, K | 1 |
| Ahmad, F; Degerman, E; Gao, G; Landstrom, TR; Manganiello, VC; Pierce, JH; Wang, LM | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G | 1 |
| Akasaki, T; Koga, H; Sumimoto, H | 1 |
| Babià, T; De Matteis, MA; di Campli, A; Egea, G; Luini, A; Valderrama, F | 1 |
| Alexandrov, A; Goepel, M; Keffel, S; Michel, MC | 1 |
| Fuortes, M; Han, H; Lyon, GJ; Melchior, M; Nathan, C | 1 |
| Agostinis, P; Assefa, Z; Merlevede, W; Valius, M; Vandenheede, JR; Vántus, T | 1 |
| Fisher, SK; Linseman, DA; Sorensen, SD | 1 |
| Chan, JS; Chen, X; Filep, JG; Ingelfinger, JR; Tang, SS; Zhang, SL | 1 |
| Bae, GU; Ha, KS; Han, JW; Hong, S; Kwon, HK; Lee, HW; Lee, HY; Lee, ZW; Seo, DW | 1 |
| Cohen, P; Shaw, M | 1 |
| Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT | 1 |
| Hamaguchi, M; Kikkawa, F; Koike, T; Liu, E; Machida, K; Matsuda, S; Seiki, M; Sein, TT; Thant, AA | 1 |
| Adlersberg, M; Gershon, MD; Hsiung, S; Liu, K; Sacktor, T; Tamir, H | 1 |
| Côté, S; Gingras, S; Simard, J | 1 |
| Gregersen, S; Hermansen, K; Thomsen, JL | 1 |
| Hayakawa, T; Ishiguro, H; Kitagawa, M; Mizuno, N; Naruse, S | 1 |
| Karlsson, A; McPhail, LC; Nixon, JB | 1 |
| Aggarwal, BB; Manna, SK | 1 |
| Coulonval, K; Dumont, JE; Kozma, SC; Lamy, F; Stein, RC; Vandeput, F | 1 |
| Chung, J; Jung, Y; Kim, D; Kim, S; Koh, H | 1 |
| Baumgarten, CM; Dent, P; Fan, S; Gao, B; He, L; Kunos, G; Nguyen, VA; Sheng, X; Spector, M; Woodward, J | 1 |
| Kanamori, Y; Kanamura, M; Kohno, K; Kozawa, O; Matsuno, H; Niwa, M; Uematsu, T | 1 |
| Fujimoto, S; Hayakawa, T; Kawakami, N; Kita, K; Yamaguchi, T | 1 |
| Blair, PJ; Sotsios, Y; Ward, SG; Westwick, J | 1 |
| Baba, A; Hashimoto, H; Koyama, Y; Matsuda, T; Yoshioka, Y | 1 |
| Kimball, SR; Miyamoto, S; Safer, B | 1 |
| Fong, CW; Lin, SC; Neo, SY; Zhang, Y | 1 |
| Baldacci, G; Pizon, V | 1 |
| Adams, M; Clayton, A; Court, J; Hobot, JA; Jasani, B; Mason, MD; Navabi, H; Newman, GR | 1 |
| Billardon, C; Carvajal-Gonzalez, S; Gompel, A; Kandouz, M; Lombet, A; Rostène, W; Zujovic, V | 1 |
| Chung, J; Jee, K; Kim, D; Kim, S; Koh, H | 1 |
| Kuznetsova, LA; Pertseva, MN; Plesneva, SA; Shpakov, AO | 2 |
| Badwey, JA; Lian, JP; Toker, A | 1 |
| Hirata, M; Horiguchi, Y; Masuda, M; Mekada, E; Miura, Y; Ryu, F; Shida, S; Takahashi, T; Takahashi, Y; Tsuneoka, M; Umata, T | 1 |
| Dolphin, AC; Nürnberg, B; Plant, TD; Scholze, A | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| An, NH; Baek, SH; Jeung, JY; Kim, HM; Kim, NS; Lee, KN; Oh, GJ; Park, ST; Song, YS; Yim, HG; Yoon, HS | 1 |
| Andrews, RP; Kepley, CL; Oliver, JM; Wilson, BS; Youssef, L | 1 |
| Huang, Y; Ishizawa, M; Ishizuka, T; Kajita, K; Kawai, Y; Kimura, M; Miura, A; Morita, H; Uno, Y; Yasuda, K | 1 |
| Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I | 1 |
| Besson, A; Davy, A; Robbins, SM; Yong, VW | 1 |
| Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K | 1 |
| Baker, RC; Farley, JM; Mamoon, AM | 1 |
| Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Surmacz, L; Wiejak, J; Wyroba, E | 1 |
| He, S; Li, X; Zhao, M | 1 |
| Cederberg, A; Enerbäck, S; Grønning, LM; Miura, N; Taskén, K | 1 |
| Chan, JS; Chen, X; Filep, JG; Hohman, TC; Pang, L; To, C; Wang, TT; Wu, XH; Zhang, SL | 1 |
| Bandyopadhyay, A; Choi, HS; Chung, J; Im, WB; Ju, JW; Kwon, HB | 1 |
| Aizawa, T; Hashizume, K; Iijima, S; Nakajima, K; Shigematsu, S; Yamauchi, K | 1 |
| Kang, SY; Kim, HM; Kim, NS; Park, SJ | 1 |
| Chen, YQ; Fisher, JH; Wang, MH; Zhou, YQ | 1 |
| Alrefai, WA; Dudeja, PK; Gill, RK; Ramaswamy, K; Saksena, S; Syed, IA; Tyagi, S | 1 |
| Gliki, G; Wheeler-Jones, C; Zachary, I | 1 |
| Fladeby, C; Grønning, M; Serck-Hanssen, G; Skar, R | 1 |
| Downes, CP; Proud, CG; Tang, X; Wang, L | 1 |
| Helliwell, PA; Kellett, GL; Rumsby, MG | 1 |
| Fujii, T; Gavrielides, MV; Kazanietz, MG; Mitsuuchi, Y; Tanaka, Y | 1 |
| Mattingly, RR; Menard, RE | 1 |
| Honda, S; Kamae, T; Kashiwagi, H; Kato, H; Kosugi, S; Kurata, Y; Shiraga, M; Tomiyama, Y | 1 |
| Burrin, JM; Fowkes, RC; Grossman, AB; Khalaf, S; Korbonits, M; Mozid, AM; Nanzer, AM; Patel, MV | 1 |
| Molenaar, P; Russell, FD | 1 |
| Crane, JK; Vezina, CM | 1 |
| Choe, YS; Choi, Y; Kim, BT; Ko, BH; Lee, KH; Paik, JY | 1 |
| Cohen, MV; Cui, L; Davis, AM; Downey, JM; Philipp, S; Yang, XM | 1 |
| Casas-González, P; García-Sáinz, JA | 1 |
| Anderson, K; Davidson, K; Ellson, C; Hawkins, PT; Stephens, LR | 1 |
| Blaser, N; Gutjahr, MC; Niggli, V; Rossy, J; Schlicht, D | 1 |
| Choi, HJ; Kim, CH; Park, YG | 1 |
| Nakamura, J | 1 |
| De Fazio, SR; Warner, CM | 1 |
| Gonzalez-Iglesias, AE; Li, S; Murano, T; Stojilkovic, SS; Tomić, M | 1 |
| Cupanikova, D; Lojek, A; Macickova, T; Nosal, R; Pecivova, J; Pekarova, M | 1 |
| Herness, S; Zhao, FL | 1 |
| Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Dailianis, S; Vouras, C | 1 |
| Chae, JI; Cho, JH; Cho, MK; Kim, DJ; Lee, KA; Lee, SH; Nam, HS; Shim, JH; Woo, KM | 1 |
| Do, SH; Kim, ST; Ryu, JH; Shin, HJ; Zuo, Z | 1 |
| Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY | 1 |
| Bongartz, H; Eulenfeld, R; Feller, SM; Hessenkemper, W; Lievens, S; Schaper, F; Simister, PC; Tavernier, J; Wolf, A | 1 |
| Münz, C; Nytko, KJ; Reichenbach, J; Romao, S; Siler, U; Tejera, E | 1 |
165 other study(ies) available for tetradecanoylphorbol acetate and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation.
Topics: Alkaloids; Androstadienes; Blood Platelets; Blood Proteins; Calcium; Collagen; Humans; Ionomycin; Phosphates; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 1992 |
Differential activation of human basophils by anti-IgE and formyl-methionyl-leucyl-phenylalanine. Indications for protein kinase C-dependent and -independent activation pathways.
Topics: Alkaloids; Androstadienes; Antibodies, Anti-Idiotypic; Basophils; Cells, Cultured; Histamine Release; Humans; Immunoglobulin E; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 1991 |
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil.
Topics: Androstadienes; Androstenes; Anti-Inflammatory Agents, Non-Steroidal; Diglycerides; Female; GTP-Binding Proteins; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Receptors, Formyl Peptide; Receptors, Immunologic; Second Messenger Systems; Tetradecanoylphorbol Acetate; Type C Phospholipases; Wortmannin | 1991 |
Activation of human neutrophil phospholipase D by three separable mechanisms.
Topics: Androstadienes; Calcimycin; Calcium; Cell Adhesion; Cell Aggregation; Egtazic Acid; Enzyme Activation; Glycerophospholipids; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Phospholipases; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1990 |
Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
Topics: Androstadienes; Blood Proteins; Diglycerides; Humans; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Interleukin-2; Lymphocytes; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Interleukin-2; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways.
Topics: Amino Acid Sequence; Androstadienes; Animals; Binding Sites; Bone Marrow Cells; Cell Adhesion; Enzyme Activation; Extracellular Matrix; Fibronectins; Hematopoietic Cell Growth Factors; Isoenzymes; Mast Cells; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Receptors, Fibronectin; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Stem Cell Factor; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Wortmannin | 1995 |
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
Topics: 3T3 Cells; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Blood; Immunosuppressive Agents; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Oligodeoxyribonucleotides; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
Topics: Androstadienes; CD28 Antigens; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-2; Leukemia, T-Cell; Lymphocyte Activation; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Protein Binding; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Animals; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Enzyme Activation; Enzyme Inhibitors; Genistein; GTP-Binding Proteins; Humans; Isoflavones; Kidney; Kinetics; Lactams, Macrocyclic; Macromolecular Substances; Pertussis Toxin; Phosphates; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Quinones; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Rifabutin; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella; Wortmannin | 1995 |
Inhibitors of signalling identify differential control processes responsible for selective effects of insulin on the expression of phosphoenolpyruvate carboxykinase and gene 33 in rat H4 hepatoma cells.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Line; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Insulin; Insulin Antagonists; Intracellular Signaling Peptides and Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphoenolpyruvate Carboxykinase (GTP); Polyenes; Protein Biosynthesis; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
Genistein inhibits potentiation by wortmannin of protein kinase C-activated phospholipase D in osteoblast-like cells.
Topics: 3T3 Cells; Androstadienes; Animals; Choline; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Genistein; Isoflavones; Kinetics; Mice; Osteoblasts; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Wortmannin has opposite effects on phorbol ester-induced DNA synthesis and phosphatidylcholine hydrolysis.
Topics: 3T3 Cells; Androstadienes; Animals; DNA; Glycerophospholipids; Hydrolysis; Mice; Palmitic Acid; Palmitic Acids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: comparison of insulin and protein kinase C modulators.
Topics: Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Epididymis; Glycogen Synthase; Insulin; Kinetics; Male; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Activation of the small GTP-binding proteins rho and rac by growth factor receptors.
Topics: 3T3 Cells; Actins; Androstadienes; Animals; Bombesin; Cell Membrane; GTP-Binding Proteins; Inositol Phosphates; Insulin; Insulin Antagonists; Mice; Phosphates; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; rac GTP-Binding Proteins; Receptors, Growth Factor; Recombinant Proteins; rhoA GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils.
Topics: Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Kinetics; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protamine Kinase; Protein Denaturation; Protein Kinase Inhibitors; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin. Dissociation of signaling pathways for insulin and phorbol ester regulation
Topics: Amino Acid Sequence; Androstadienes; Base Sequence; Gene Expression Regulation, Enzymologic; Insulin; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
Ethanol enhances the stimulatory effects of insulin and insulin-like growth factor-1 on DNA synthesis in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Androstadienes; Animals; Culture Media, Serum-Free; DNA; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Fibroblast Growth Factors; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Kinetics; Lysophospholipids; Mice; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Thymidine; Wortmannin | 1995 |
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase.
Topics: Amino Acid Sequence; Androstadienes; Animals; Anti-Inflammatory Agents; Blood; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Culture Media; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Guanine Nucleotide Exchange Factors; Humans; Insulin; Insulin Antagonists; Kinetics; Molecular Sequence Data; Peptides; Protein Kinases; Proteins; Receptor, Insulin; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Wortmannin | 1994 |
Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Female; Guinea Pigs; In Vitro Techniques; Kinetics; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 1994 |
Effect of inhibitors of distinct signalling pathways on neutrophil Q2- generation in response to tumor necrosis factor-alpha, and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine
Topics: Alkaloids; Androstadienes; Antigens, CD; CD18 Antigens; Genistein; Integrins; Isoflavones; Lymphocyte Function-Associated Antigen-1; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella; Wortmannin | 1993 |
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.
Topics: Androstadienes; Autoradiography; Humans; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphates; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipase D; Phospholipids; Phosphorus Radioisotopes; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Wortmannin | 1993 |
Signaling by hemolytically inactive C5b67, an agonist of polymorphonuclear leukocytes.
Topics: Alkaloids; Androstadienes; Animals; Antigens, CD; Benzophenanthridines; Benzoquinones; Calcium; Cell Line, Transformed; Chemotaxis, Leukocyte; Chlorocebus aethiops; Complement C5; Complement System Proteins; Cyclic AMP; Enzyme Inhibitors; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Inositol Phosphates; Intercellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Naphthalenes; Neutrophils; Peptides; Pertussis Toxin; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Quinones; Receptor, Anaphylatoxin C5a; Receptors, Complement; Recombinant Fusion Proteins; Respiratory Burst; Rifabutin; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wasp Venoms; Wortmannin | 1996 |
Wortmannin inhibits the activation of MAP kinase following vasopressin V1 receptor stimulation.
Topics: Androstadienes; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Deamino Arginine Vasopressin; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Piperidines; Quinolones; Rats; Receptors, Vasopressin; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Choline phosphate and phorbol ester potentiate the mitogenic effect of insulin by competitive mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Androstadienes; Animals; Enzyme Inhibitors; Insulin; Mice; Mitogens; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Two signaling pathways can lead to Fas ligand expression in CD8+ cytotoxic T lymphocyte clones.
Topics: Androstadienes; Animals; Base Sequence; Clone Cells; Cytotoxicity, Immunologic; Fas Ligand Protein; Gene Expression Regulation; Ionomycin; Isoenzymes; Ligands; Membrane Glycoproteins; Mice; Mice, Inbred CBA; Molecular Sequence Data; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Receptors, Antigen, T-Cell; RNA, Messenger; Signal Transduction; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Effects of wortmannin on glucose uptake and protein kinase C activity in rat adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipocytes; Androstadienes; Animals; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Isoenzymes; Isoquinolines; Male; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Rats; Rats, Wistar; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Phosphoinositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaIIbbeta3 integrin.
Topics: Amino Acid Sequence; Androstadienes; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Ligands; Molecular Sequence Data; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Line; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Humans; Immunosuppressive Agents; Insulin; Kidney; Kinetics; Mice; Nicotinic Acids; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.
Topics: Amino Acid Sequence; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Endothelins; Enzyme Activation; Estrenes; Guinea Pigs; Humans; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Receptor, Endothelin A; Receptors, Endothelin; Sensitivity and Specificity; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Wortmannin | 1996 |
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells.
Topics: Androstadienes; Animals; Aspergillus; Carcinogens; Cell Survival; Fumonisins; Fusaric Acid; Fusarium; Indoles; Interleukin-2; Interleukin-5; Lymphocyte Activation; Mice; Mycotoxins; Ochratoxins; Patulin; Penicillium; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured; Wortmannin; Zearalenone; Zeranol | 1996 |
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Blotting, Western; Chromones; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Wortmannin and Li+ specifically inhibit clathrin-independent endocytic internalization of bulk fluid.
Topics: Ammonium Chloride; Androstadienes; Antibodies, Monoclonal; Calcium; Cell Line; Clathrin; Endocytosis; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Fibrosarcoma; Horseradish Peroxidase; Humans; Hydrogen-Ion Concentration; Lithium; Microscopy, Electron; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Proton-Translocating ATPases; Tetradecanoylphorbol Acetate; Transferrin; Tumor Cells, Cultured; Wortmannin | 1996 |
Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood.
Topics: Actin Depolymerizing Factors; Androstadienes; Animals; Calcimycin; Calcium; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ionophores; Marine Toxins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Swine; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Culture Media, Conditioned; Drosophila; Drosophila Proteins; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Mice; Polyenes; Protein Kinases; Proto-Oncogene Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wnt1 Protein; Wortmannin | 1996 |
Parietal cell MAP kinases: multiple activation pathways.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cyclic AMP; Cytosol; Enzyme Activation; Epidermal Growth Factor; Gastric Mucosa; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parasympathomimetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.
Topics: Androstadienes; Animals; Cell Membrane; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; Fluorescent Dyes; Lysosomes; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred C3H; Morpholines; Organelles; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Pinocytosis; Pseudopodia; Receptors, Fc; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
Topics: Actin Cytoskeleton; Actins; Androstadienes; Blood Platelets; Cytochalasin B; Enzyme Inhibitors; Gelsolin; Humans; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphotransferases (Alcohol Group Acceptor); Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Activation of mitogen-activated protein kinase by norepinephrine in brown adipocytes from rats.
Topics: Adipose Tissue, Brown; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cold Temperature; Enzyme Activation; Female; Insulin; Norepinephrine; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Inhibition of protein kinase C-dependent noradrenaline release by wortmannin in PC12 cells.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Calcium; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Naphthalenes; Norepinephrine; PC12 Cells; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Potassium; Protein Kinase C; Rats; Secretory Rate; Tetradecanoylphorbol Acetate; Wasp Venoms; Wortmannin | 1997 |
Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation.
Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Insulin; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Wortmannin | 1997 |
Activation of G-proteins with AIF-4 induces LFA-1-mediated adhesion of T-cell hybridoma cells to ICAM-1 by signal pathways that differ from phorbol ester- and manganese-induced adhesion.
Topics: Aluminum Compounds; Androstadienes; Animals; Cell Adhesion; Enzyme Activation; Enzyme Inhibitors; Estrenes; Fluorides; Genistein; GTP-Binding Proteins; Humans; Hybridomas; Indoles; Intercellular Adhesion Molecule-1; Isoflavones; Lymphocyte Function-Associated Antigen-1; Maleimides; Manganese; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
The enhancement by wortmannin of protein kinase C-dependent activation of phospholipase D in vascular endothelial cells.
Topics: Androstadienes; Animals; Cattle; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Genistein; Glycerophospholipids; Isoenzymes; Isoflavones; Morpholines; Oxidants; Phosphatidic Acids; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorus Radioisotopes; Protein Kinase C; Sensitivity and Specificity; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism.
Topics: Androstadienes; Animals; Brain-Derived Neurotrophic Factor; Carcinogens; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Enzyme Inhibitors; Gene Expression Regulation; Genes, Immediate-Early; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotrophin 3; NF-kappa B; Protein Kinase C; Proto-Oncogene Proteins; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, Nerve Growth Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Wortmannin | 1997 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase.
Topics: Androstadienes; Antibodies, Monoclonal; Antigens, CD; CD28 Antigens; CD3 Complex; Chromones; Enzyme Inhibitors; Humans; Jurkat Cells; Lymphocyte Activation; Morpholines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
Topics: Androstadienes; Antigens, CD; Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Degranulation; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Tetraspanin 30; Wortmannin | 1997 |
Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism.
Topics: Androstadienes; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD28 Antigens; Cell Survival; Clonal Anergy; Humans; Interleukin-2; Ionomycin; Lactams, Macrocyclic; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Mycotoxins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Receptor-CD3 Complex, Antigen, T-Cell; Rifabutin; Signal Transduction; Substrate Specificity; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
p70s6k is activated by CCK in rat pancreatic acini.
Topics: Amino Acid Sequence; Androstadienes; Animals; Bombesin; Carbachol; Cells, Cultured; Cholecystokinin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Genistein; Ionomycin; Isoflavones; Kinetics; Male; Molecular Sequence Data; Pancreas; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Thionucleotides; Vasoactive Intestinal Peptide; Wortmannin | 1997 |
Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidylinositol 3-kinase in phosp
Topics: Androstadienes; Cell Differentiation; Cell Membrane; Chromones; Enzyme Activation; HL-60 Cells; Humans; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Cricetulus; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nociceptin Receptor; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Opioid; Recombinant Proteins; Tetradecanoylphorbol Acetate; Wortmannin | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Prostaglandin E2 stimulates sodium-dependent phosphate transport in osteoblastic cells via a protein kinase C-mediated pathway.
Topics: Androstadienes; Animals; Biological Transport; Cells, Cultured; Dinoprostone; DNA; Genistein; Indomethacin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Osteoblasts; Phosphates; Protein Kinase C; Rats; Sodium; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C.
Topics: Androstadienes; Animals; Catechols; Cells, Cultured; Cryopreservation; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Hepatocyte Growth Factor; Humans; Hydrogen-Ion Concentration; Kidney Neoplasms; Kinetics; Mice; Mice, Inbred Strains; Nitriles; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1998 |
Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k.
Topics: 3T3 Cells; Androstadienes; Animals; Calcium; Down-Regulation; Epidermal Growth Factor; Ionomycin; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates; Wortmannin | 1998 |
Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated, CD11b/CD18-dependent cell-cell adhesion of human neutrophils: evidence for an ERK-independent pathway.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line, Transformed; Chromones; Complement C5a; Endothelium, Vascular; Epitopes; Humans; Ionophores; Macrophage-1 Antigen; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; Up-Regulation; Wortmannin | 1998 |
Activated T lymphocytes induce degranulation and cytokine production by human mast cells following cell-to-cell contact.
Topics: Androstadienes; Antibodies, Monoclonal; beta-N-Acetylhexosaminidases; Bone Marrow Cells; CD3 Complex; Cell Adhesion; Cell Communication; Coculture Techniques; Cytokines; Cytoplasmic Granules; Histamine Release; Humans; Kinetics; Lymphocyte Activation; Mast Cells; Phosphoinositide-3 Kinase Inhibitors; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 1998 |
Mitogenic-factor-dependent regulation of lipopolysaccharide and cytokine mixture-mediated hepatocyte nitric oxide synthesis in vitro.
Topics: Androstadienes; Animals; Cells, Cultured; Cytokines; Enzyme Activation; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Hydroxyurea; Lipopolysaccharides; Liver; Mice; Mice, Inbred ICR; Mitogens; Nitric Oxide; Oxidation-Reduction; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma.
Topics: Amino Acid Transport System X-AG; Androstadienes; Animals; Biological Transport; Carcinogens; Carrier Proteins; Cell Membrane; Enzyme Inhibitors; Glioma; Glutamate Plasma Membrane Transport Proteins; Glutamates; Glycine; Microscopy, Confocal; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Symporters; Tetradecanoylphorbol Acetate; Tritium; Tumor Cells, Cultured; Wortmannin | 1998 |
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
Topics: ADP Ribose Transferases; Androstadienes; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Size; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Humans; Hypotonic Solutions; Indoles; Intestines; Iodine Radioisotopes; Maleimides; Osmotic Pressure; Phosphorylation; ras Proteins; Rubidium Radioisotopes; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not by TPA.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Hepatocellular; Enzyme Activation; Enzyme Inhibitors; Hepatitis B Surface Antigens; Humans; Insulin; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1998 |
A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate.
Topics: Androstadienes; Blood Platelets; Calcium; Calpain; Enzyme Activation; Humans; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protease Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1998 |
Ortho-substituted polychlorinated biphenyls activate respiratory burst measured as luminol-amplified chemoluminescence in human granulocytes.
Topics: Androstadienes; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Granulocytes; Humans; Indoles; Luminescent Measurements; Luminol; Maleimides; Phosphodiesterase Inhibitors; Phospholipase D; Polychlorinated Biphenyls; Protein Kinase C; Respiratory Burst; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Human B lymphocytes synthesize the 92-kDa gelatinase, matrix metalloproteinase-9.
Topics: Androstadienes; B-Lymphocytes; Captopril; Cell Movement; Collagenases; Concanavalin A; Cytokines; Gene Expression Regulation, Enzymologic; Growth Substances; Herpesvirus 4, Human; Humans; Lipopolysaccharides; Matrix Metalloproteinase 9; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Transformation, Genetic; Transforming Growth Factor beta; Wortmannin | 1998 |
Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
Topics: Androstadienes; Animals; Bombesin; Carbachol; Carrier Proteins; Cholecystokinin; Chromones; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Methionine; Morpholines; Pancreas; Peptide Initiation Factors; Phosphoproteins; Polyenes; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.
Topics: Androstadienes; Animals; Aprotinin; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Creatine Kinase; Cyclic AMP; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; GTP-Binding Proteins; Heart; Heart Ventricles; Isoenzymes; Isoproterenol; Male; Models, Cardiovascular; Myocardium; Neuropeptide Y; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin | 1998 |
A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Antimanic Agents; Calcium; Calcium Channels; Calcium Channels, N-Type; Carcinogens; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Hippocampus; Lithium Chloride; Membrane Potentials; Naphthalenes; Neurons; Phosphodiesterase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; ras Proteins; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Ca(2+)-dependent enhancement of [3H]noradrenaline uptake in PC12 cells through calmodulin-dependent kinases.
Topics: Actins; Amino Acid Sequence; Androstadienes; Animals; Biological Transport; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carcinogens; Carrier Proteins; Cytochalasin D; Desipramine; Dopamine; Enzyme Inhibitors; Marine Toxins; Molecular Sequence Data; Myosin Light Chains; Naphthalenes; Neurons; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleic Acid Synthesis Inhibitors; Oxazoles; PC12 Cells; Peptide Fragments; Phosphorylation; Rats; Sympathomimetics; Symporters; Tetradecanoylphorbol Acetate; Tritium; Wortmannin | 1998 |
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
Topics: Androstadienes; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; HL-60 Cells; Humans; Isoenzymes; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neoplasm Proteins; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella; Wortmannin | 1998 |
Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3-kinase in human neutrophils.
Topics: Androstadienes; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Lysophosphatidylcholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte-macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cytokines; Drug Synergism; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin | 1999 |
Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Arachidonic Acid; Calcium; Cell Line; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Isoenzymes; Macrophages; Mice; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-epsilon; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Specific signaling pathways in the regulation of TNF-alpha mRNA synthesis and TNF-alpha secretion in RBL-2H3 mast cells stimulated through the high affinity IgE receptor.
Topics: Androstadienes; Animals; beta-N-Acetylhexosaminidases; Egtazic Acid; Enzyme Inhibitors; Gene Expression; Indoles; Leukemia, Basophilic, Acute; Maleimides; Mast Cells; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Receptors, IgE; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 1998 |
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Affinity modulation of very late antigen-5 through phosphatidylinositol 3-kinase in mast cells.
Topics: Androstadienes; Animals; Cell Line; Fibronectins; Humans; Mast Cells; Mice; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Receptors, Fibronectin; Receptors, IgE; Tetradecanoylphorbol Acetate; Type C Phospholipases; Wortmannin | 1999 |
IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Insulin Receptor Substrate Proteins; Interleukin-3; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; STAT6 Transcription Factor; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin | 1999 |
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils.
Topics: Androstadienes; Chromones; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Indoles; Leukotriene B4; Maleimides; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin | 1999 |
Morphological changes in the Golgi complex correlate with actin cytoskeleton rearrangements.
Topics: Actins; Androstadienes; Animals; Biological Transport; Brefeldin A; Cell Membrane; Chromones; Cytochalasin D; Cytoskeleton; Depsipeptides; Enzyme Inhibitors; Epidermal Growth Factor; Glycosaminoglycans; Golgi Apparatus; Lysophospholipids; Morpholines; Nucleic Acid Synthesis Inhibitors; Peptides, Cyclic; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Differential regulation of 46 and 54 kDa jun N-terminal kinases and p38 mitogen-activated protein kinase by human alpha(1A)-adrenoceptors expressed in Rat-1 cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gene Expression; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phenylephrine; Phosphoinositide-3 Kinase Inhibitors; Prazosin; Protein Kinase C; Pyrrolidinones; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 1999 |
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.
Topics: Androstadienes; Cell Adhesion; Cell Size; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 2; Humans; Integrins; Neutrophil Activation; Neutrophils; Nitriles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor.
Topics: Androstadienes; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Wortmannin | 1999 |
Attenuation of focal adhesion kinase signaling following depletion of agonist-sensitive pools of phosphatidylinositol 4,5-bisphosphate.
Topics: Androstadienes; Animals; Arsenicals; Cell Adhesion Molecules; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Myosin-Light-Chain Kinase; Neuroblastoma; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, Cholinergic; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
Topics: Androstadienes; Angiotensinogen; Animals; Cell Line, Transformed; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Insulin; Kidney Tubules, Proximal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Hydrogen peroxide activates p70(S6k) signaling pathway.
Topics: Androstadienes; Animals; Calcium; Catalase; Cell Line; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Indoles; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 1999 |
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1.
Topics: Androstadienes; Animals; Cell Line, Transformed; Clone Cells; Enzyme Activation; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins pp60(c-src); ras Proteins; Rats; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C.
Topics: Androstadienes; Animals; Calcium; Calcium Channels; Carbazoles; Cell Membrane; Cells, Cultured; Cytosol; Enzyme Inhibitors; Indoles; Isoenzymes; Naphthalenes; Phosphatidylinositol 3-Kinases; Protein Kinase C; Serotonin; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Wortmannin | 2000 |
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin | 2000 |
Endothelin-1 (ET-1)-potentiated insulin secretion: involvement of protein kinase C and the ET(A) receptor subtype.
Topics: Adrenergic Antagonists; Androstadienes; Animals; Cholinergic Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enzyme Inhibitors; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Naphthalenes; Peptide Fragments; Peptides, Cyclic; Phorbol Esters; Protein Kinase C; Receptor, Endothelin A; Receptors, Endothelin; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Effects of an inhibitor of myosin light chain kinase on amylase secretion from rat pancreatic acini.
Topics: Amylases; Androstadienes; Animals; Calcimycin; Calcium; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Male; Myosin-Light-Chain Kinase; Pancreas; Rats; Rats, Wistar; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 2000 |
Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways: dependent or independent of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Cell Degranulation; Cell Membrane; Cells, Cultured; Cytoplasmic Granules; Enzyme Activation; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Microscopy, Electron; Mitogen-Activated Protein Kinase Kinases; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Vacuoles; Wortmannin | 2000 |
Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Ceramides; DNA Probes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Hydrogen Peroxide; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Organ Specificity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 2000 |
Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hepatocyte Growth Factor; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Wortmannin | 2000 |
Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway.
Topics: 3T3 Cells; Androstadienes; Animals; Chromones; COS Cells; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin; Zinc | 2000 |
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Usefulness of grading of neutrophil aggregate size by laser-light scattering technique for characterizing stimulatory and inhibitory effects of agents on aggregation.
Topics: Androstadienes; Bucladesine; Cell Aggregation; Cell Count; Cytochalasin B; Dinoprostone; Enzyme Activators; Enzyme Inhibitors; Humans; Lasers; Light; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Particle Size; Phorbol Esters; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Scattering, Radiation; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Phorbor myristate acetate induces NADPH oxidase activity of cytochalasin B-primed neutrophils through the protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Androstadienes; Cytochalasin B; Ethanol; Granulocyte Colony-Stimulating Factor; Humans; Indoles; Maleimides; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes.
Topics: Abatacept; Androstadienes; Antigens, CD; Antigens, Differentiation; Calcium; CD2 Antigens; CD28 Antigens; CD3 Complex; Cell Culture Techniques; Cell Division; Chemokine CCL5; CTLA-4 Antigen; Down-Regulation; Humans; Immunoconjugates; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
Topics: Androstadienes; Angiotensin II; Animals; Animals, Newborn; Astrocytes; Bradykinin; Bucladesine; Cerebral Cortex; Chelating Agents; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Pertussis Toxin; Phosphoproteins; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Signal transduction pathways that contribute to increased protein synthesis during T-cell activation.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Eukaryotic Initiation Factor-2B; Eukaryotic Initiation Factor-4E; Humans; Ionomycin; Kinetics; Lymphocyte Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner.
Topics: Androstadienes; Bucladesine; Calcimycin; Calcineurin; Calcium; Calcium Signaling; Cyclosporine; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Humans; Kinetics; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Nuclear Proteins; Protein Kinase C; Proteins; RGS Proteins; RNA, Messenger; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin | 2000 |
Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.
Topics: Androstadienes; Blood Proteins; Blotting, Western; Cell Division; Cell Line; Cyclic AMP; Down-Regulation; Enzyme Activation; Flavonoids; Guanosine Diphosphate; Guanosine Triphosphate; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry.
Topics: Androstadienes; Antigen-Presenting Cells; Antigens, CD; Biomarkers; Calcium; Dendritic Cells; Flow Cytometry; HLA-DP Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Immunomagnetic Separation; K562 Cells; Microscopy, Electron; Staining and Labeling; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Wortmannin | 2001 |
Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.
Topics: Androstadienes; Apoptosis; Bacterial Proteins; Bacterial Toxins; bcl-X Protein; Biomarkers; Cell Differentiation; Cell Size; DNA Fragmentation; Gene Expression Regulation; Humans; Microtubule-Associated Proteins; Neuroblastoma; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphopyruvate Hydratase; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; rhoA GTP-Binding Protein; Signal Transduction; Staurosporine; Synaptophysin; Tetradecanoylphorbol Acetate; Thapsigargin; Tretinoin; Tumor Cells, Cultured; Wortmannin | 2001 |
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Kinetics; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Bacterial Toxins; Diglycerides; Enzyme Inhibitors; Guanylyl Imidodiphosphate; Hormones; Humans; Insulin; Insulin Antagonists; Mollusca; Naphthalenes; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils.
Topics: Androstadienes; Animals; Antibody Specificity; Antigen-Antibody Reactions; Enzyme Activation; Guinea Pigs; Immune Sera; Kinetics; Marine Toxins; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Oxazoles; Oxidative Stress; p21-Activated Kinases; Peptide Fragments; Phosphopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.
Topics: Androstadienes; Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; GTP Phosphohydrolases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Mutation; Plasmids; Protein Kinase C; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Cell Surface; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation; Transfection; Vero Cells; Wortmannin | 2001 |
Functional expression and characterization of a voltage-gated CaV1.3 (alpha1D) calcium channel subunit from an insulin-secreting cell line.
Topics: Androstadienes; Animals; Barium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Female; Gene Expression; GTP-Binding Proteins; Ion Channel Gating; Isradipine; Myocardium; Neurons; Oocytes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Wortmannin; Xenopus laevis | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Phosphatidylinositol 3-kinase regulates proliferation of RAW 264.7 macrophages.
Topics: Androstadienes; Animals; Cell Cycle; Cell Division; Cell Line; Chromones; Enzyme Inhibitors; Gene Expression; Genes, fos; Genes, jun; Macrophages; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Regulation of the very late antigen-4-mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and phosphatidylinositol 3-kinase.
Topics: Acridines; Androstadienes; Animals; Basophils; Calcimycin; Calcium; Cell Adhesion; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Humans; Immunologic Capping; Integrin alpha4beta1; Integrins; Intracellular Signaling Peptides and Proteins; Ionophores; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Receptors, IgE; Receptors, Lymphocyte Homing; Recombinant Fusion Proteins; Signal Transduction; src-Family Kinases; Syk Kinase; Tetradecanoylphorbol Acetate; Transfection; Up-Regulation; Vascular Cell Adhesion Molecule-1; Wortmannin | 2001 |
Differential effect of PKC isoform on insulin- and phorbol ester-stimulated glucose uptake mechanism in rat adipocytes.
Topics: Adipocytes; Androstadienes; Animals; Biological Transport, Active; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Glucose; In Vitro Techniques; Indoles; Insulin; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells.
Topics: Androstadienes; Brain Neoplasms; Butadienes; Cell Adhesion; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Focal Adhesions; Glioma; Humans; Isoenzymes; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 2001 |
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin | 2002 |
Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.
Topics: Acetylcholine; Amides; Androstadienes; Animals; Calcium; Chromones; Enzyme Activation; In Vitro Techniques; Male; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phospholipase D; Pyridines; rhoA GTP-Binding Protein; Swine; Tetradecanoylphorbol Acetate; Trachea; Wortmannin | 2001 |
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.
Topics: Adenosine Diphosphate; Androstadienes; Calcimycin; Calcium Signaling; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Indoles; Ionophores; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxanes; Type C Phospholipases; Wortmannin | 2001 |
Effect of wortmannin and phorbol ester on Paramecium fluid-phase uptake in the presence of transferrin.
Topics: Androstadienes; Animals; Biomarkers; Endocytosis; Endosomes; Enzyme Activation; Indoles; Isoquinolines; Maleimides; Paramecium; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Transferrin; Wortmannin | 2001 |
[A study of different intracellular signal transduction pathways on phagocytosis of fibronectin by retinal pigment epithelial cells].
Topics: Androstadienes; Cells, Cultured; Enzyme Inhibitors; Fetus; Fibronectins; Genistein; Humans; Naphthalenes; Phagocytosis; Phosphoinositide-3 Kinase Inhibitors; Pigment Epithelium of Eye; Protein Kinase C; Protein-Tyrosine Kinases; Retina; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Flavonoids; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Insulin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2002 |
Molecular mechanism(s) of insulin action on the expression of the angiotensinogen gene in kidney proximal tubular cells.
Topics: Androstadienes; Angiotensinogen; Animals; Artificial Gene Fusion; Cell Line; Diglycerides; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Human Growth Hormone; Humans; Insulin; Kidney Tubules, Proximal; Naphthalenes; Opossums; Peptide Fragments; Promoter Regions, Genetic; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Bacterial Toxins; Enzyme Inhibitors; Hormones; Humans; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Mollusca; Muscle, Skeletal; Muscle, Smooth; Naphthalenes; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
Involvement of phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Female; Mitogen-Activated Protein Kinases; Morpholines; Oocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Progesterone; Ranidae; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
IGF-1 regulates migration and angiogenesis of human endothelial cells.
Topics: Androstadienes; Cell Movement; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Insulin-Like Growth Factor I; Morpholines; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells.
Topics: Androstadienes; Apoptosis; Bucladesine; Cell Differentiation; Cell Division; Chromones; Colforsin; Enzyme Inhibitors; HL-60 Cells; Humans; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases, 70-kDa; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages.
Topics: Androstadienes; Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; DNA-Binding Proteins; Enzyme Activation; Hepatocyte Growth Factor; I-kappa B Kinase; I-kappa B Proteins; Interferon-gamma; Isoenzymes; Lipopolysaccharides; Macrophages; Mice; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
Inhibition of apical Cl-/OH- exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Androstadienes; Biological Transport; Caco-2 Cells; Carcinogens; Chloride-Bicarbonate Antiporters; Chlorides; Chromones; Enzyme Inhibitors; Humans; Insulin Receptor Substrate Proteins; Isoenzymes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Wortmannin | 2002 |
Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis.
Topics: Androstadienes; Carcinogens; Chromones; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Cholinergic activation of glucose transport in bovine chromaffin cells involves calmodulin and protein kinase Czeta signaling.
Topics: Acetylcholine; Androstadienes; Animals; Biological Transport; Blotting, Northern; Calmodulin; Cattle; Cholinergic Agonists; Chromaffin Cells; Down-Regulation; Enzyme Inhibitors; Genistein; Glucose; Mitogen-Activated Protein Kinases; Models, Biological; Mutagens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2002 |
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Topics: Androstadienes; Astrocytoma; Calcium Signaling; Carbachol; Chelating Agents; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Kinase Inhibitors; Protein Kinases; Receptors, Muscarinic; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Wortmannin | 2003 |
Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways.
Topics: Androstadienes; Animals; Enzyme Inhibitors; Fructose; Glucose Transporter Type 2; Intestinal Absorption; Male; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Ubiquitin; Wortmannin | 2003 |
Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway.
Topics: Androstadienes; Apoptosis; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostatic Neoplasms; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA Interference; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin | 2003 |
Activation of integrin alpha IIb beta 3 in the glycoprotein Ib-high population of a megakaryocytic cell line, CMK, by inside-out signaling.
Topics: Alprostadil; Androstadienes; Calcimycin; Cell Line; Cytochalasin D; Humans; Ionophores; Isoenzymes; Megakaryocytes; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Ribavirin; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2004 |
Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway.
Topics: Androstadienes; Animals; Butadienes; Carcinogens; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ghrelin; Indoles; Maleimides; MAP Kinase Signaling System; Nitriles; Peptide Hormones; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pituitary Gland; Pituitary Neoplasms; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrphostins; Wortmannin | 2004 |
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.
Topics: Alkaloids; Amides; Androstadienes; Benzophenanthridines; Endothelin-1; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Myocardial Contraction; Myocardium; Myosin-Light-Chain Kinase; Phenanthridines; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Urotensins; Wortmannin | 2004 |
Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection.
Topics: Adenosine Triphosphate; Androstadienes; Apoptosis; Bacterial Adhesion; Caspase 3; Caspase 7; Caspases; Cell Death; Cell Line, Tumor; Escherichia coli; Escherichia coli Proteins; HeLa Cells; Humans; Immunohistochemistry; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Kinases; Protein Transport; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Wortmannin | 2005 |
PMA-enhanced neutrophil [18F]FDG uptake is independent of integrin occupancy but requires PI3K activity.
Topics: Acridines; Androstadienes; Antineoplastic Agents; Carcinogens; Cells, Cultured; Fluorodeoxyglucose F18; Hexokinase; Humans; Integrins; Luminescent Measurements; Neutrophils; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Radiopharmaceuticals; Receptors, Immunologic; Respiratory Burst; Tetradecanoylphorbol Acetate; Tomography, Emission-Computed; Wortmannin | 2005 |
Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.
Topics: Acetamides; Adenosine; Adenosine A2 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Alkaloids; Androstadienes; Animals; Aorta; Benzophenanthridines; Constriction; Enzyme Activators; Female; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Phenanthridines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Purines; Rabbits; Receptor, Adenosine A2B; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin; Xanthines | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation.
Topics: Amino Acid Sequence; Androstadienes; Animals; Cells, Cultured; Enzyme Activation; Immunoglobulin G; Mice; Mice, Mutant Strains; Microspheres; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Peritoneum; Phosphatidylinositol Phosphates; Phosphoproteins; Protein Structure, Tertiary; Reactive Oxygen Species; Response Elements; Signal Transduction; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Wortmannin | 2006 |
Ezrin/moesin in motile Walker 256 carcinosarcoma cells: signal-dependent relocalization and role in migration.
Topics: Androstadienes; Animals; Carcinogens; Carcinoma 256, Walker; Cell Movement; Cell Polarity; Cytoskeletal Proteins; Down-Regulation; Enzyme Activation; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microfilament Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; rac1 GTP-Binding Protein; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Transfection; Wortmannin | 2007 |
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.
Topics: 5' Flanking Region; Androstadienes; Carbazoles; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; K562 Cells; Megakaryocytes; Mutation; Neuraminidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; Sialyltransferases; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2007 |
Protein kinase C-dependent antilipolysis by insulin in rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Androstadienes; Angiotensin II; Animals; Carbazoles; Carcinogens; Dobutamine; Enzyme Activation; Enzyme Inhibitors; Glycerol; Imidazoles; Indoles; Insulin; Isoenzymes; Lipolysis; Male; Maleimides; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Wortmannin | 2007 |
Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antibodies; Blastocyst; Cell Proliferation; Cells, Cultured; Chromones; Cross-Linking Reagents; Dose-Response Relationship, Drug; Female; Histocompatibility Antigens Class I; Immunoglobulins; Immunoprecipitation; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nucleosides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Pyridazines; Pyrimidines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin | 2007 |
Dopamine inhibits basal prolactin release in pituitary lactotrophs through pertussis toxin-sensitive and -insensitive signaling pathways.
Topics: Adenylyl Cyclase Inhibitors; Androstadienes; Animals; Calcium; Cells, Cultured; Cyclic AMP; Dopamine; Female; Lithium; Pertussis Toxin; Pituitary Gland; Potassium Channels, Inwardly Rectifying; Prolactin; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2008 |
Inhibition of superoxide generation and myeloperoxidase release by carvedilol after receptor and nonreceptor stimulation of human neutrophils.
Topics: Adrenergic beta-Antagonists; Androstadienes; Calcimycin; Carbazoles; Carvedilol; Humans; In Vitro Techniques; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidants; Peroxidase; Phosphatidylinositol 3-Kinases; Propanolamines; Protein Kinase C; Receptors, Adrenergic, beta; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2008 |
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
Topics: Androstadienes; Animals; Benzylamines; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromones; Delayed Rectifier Potassium Channels; Enzyme Inhibitors; Estrenes; Male; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C beta; Polylysine; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Taste; Taste Buds; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin | 2009 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Evidence for phosphatidylinositol-3-OH-kinase (PI3-kinase) involvement in Cd-mediated oxidative effects on hemocytes of mussels.
Topics: Androstadienes; Animals; Cadmium Chloride; Cell Survival; Hemocytes; Lipid Peroxidation; Malondialdehyde; Mytilus; Nitric Oxide; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Superoxides; Tetradecanoylphorbol Acetate; Water Pollutants, Chemical; Wortmannin | 2012 |
Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.
Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endothelial Growth Factors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Morpholines; Naphthoquinones; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Ribosomal Protein S6 Kinases, 90-kDa; Skin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Wortmannin | 2012 |
Caffeine-induced inhibition of the activity of glutamate transporter type 3 expressed in Xenopus oocytes.
Topics: Androstadienes; Animals; Caffeine; Central Nervous System Stimulants; Excitatory Amino Acid Transporter 3; Female; Oocytes; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Wortmannin; Xenopus | 2013 |
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 2013 |
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Butadienes; Cell Membrane; Chromones; HEK293 Cells; Humans; Interleukin-6; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Translocation, Genetic; Wortmannin | 2015 |
Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.
Topics: Adenine; Androstadienes; Benzylamines; Candida albicans; Cell Nucleus; Extracellular Traps; Granulomatous Disease, Chronic; Histones; Humans; Hydrolases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Wortmannin | 2015 |