tetradecanoylphorbol acetate and u 0126

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

Topics: Animals; Butadienes; COS Cells; DNA; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Kinetics; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-6; Ionomycin; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection

Topics: 3T3 Cells; Androstadienes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin

Topics: Animals; Astrocytes; Bucladesine; Butadienes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate

Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins

Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Caspases; Cell Line; Cell Survival; Cisplatin; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HeLa Cells; Humans; Indoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Time Factors

Topics: Anisomycin; Blotting, Northern; Blotting, Western; Butadienes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Ionophores; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha

Topics: Adenosine Triphosphate; Butadienes; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Histamine; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Ornithine Decarboxylase; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Tetradecanoylphorbol Acetate

Topics: Butadienes; DNA-Binding Proteins; Enzyme Activation; Genes, Dominant; Humans; I-kappa B Kinase; I-kappa B Proteins; Indoles; Isoenzymes; Kinetics; Maleimides; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Protein Kinase C; Protein Kinase C-alpha; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

Topics: Butadienes; Electrophoresis, Gel, Two-Dimensional; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Profiling; Humans; K562 Cells; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Proteome; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate; Transfection

Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins

Topics: Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Lymphocyte Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Tetradecanoylphorbol Acetate

Topics: Amyloid beta-Protein Precursor; Butadienes; Calcimycin; Calcium; Carcinogens; Enzyme Inhibitors; Gene Expression; Humans; Ionomycin; Ionophores; Leukocytes, Mononuclear; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Protein Kinase C; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate

Topics: Alkaloids; Animals; Benzophenanthridines; Butadienes; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Immunoblotting; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase Kinases; Nitriles; Phenanthridines; Precipitin Tests; Proto-Oncogene Proteins c-sis; Tetradecanoylphorbol Acetate; Trabecular Meshwork

Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Animals; Butadienes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Lineage; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Ionomycin; MAP Kinase Signaling System; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mitogens; Models, Immunological; Nitriles; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors

Topics: Androstadienes; Brain Neoplasms; Butadienes; Cell Adhesion; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Focal Adhesions; Glioma; Humans; Isoenzymes; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

Topics: Adenoviridae; Animals; Blotting, Western; Butadienes; Cats; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Detergents; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Insulin; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; Time Factors

Topics: Antigens, CD; Antineoplastic Agents; Apoptosis; Butadienes; Cell Differentiation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Granulocytes; Humans; Leukemia, Myeloid; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tretinoin

Topics: Adipocytes; Animals; Butadienes; Cell Line; Enzyme Inhibitors; Isoenzymes; Lipoprotein Lipase; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nitriles; Oligonucleotides, Antisense; Polyribosomes; Protein Biosynthesis; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-raf; RNA, Messenger; Tetradecanoylphorbol Acetate

Topics: Bone Neoplasms; Butadienes; Carcinoma; Chondrosarcoma; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Ovarian Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Trypsin Inhibitor, Kunitz Soybean; Tumor Cells, Cultured

Topics: Animals; Butadienes; Calcium Signaling; CD3 Complex; CD4-Positive T-Lymphocytes; Clonal Anergy; Enzyme Inhibitors; Genes, ras; Humans; Interleukin-2; Ionomycin; Lymphocyte Activation; MAP Kinase Kinase 1; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Moloney murine leukemia virus; Nitriles; Ovalbumin; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection

Topics: Butadienes; Cell Adhesion; Cell Differentiation; Cell Membrane; Enzyme Activation; Enzyme Inhibitors; Kinetics; Leukemia; MAP Kinase Kinase 1; MAP Kinase Signaling System; Megakaryocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Blotting, Western; Breast Neoplasms; Butadienes; COUP Transcription Factor I; COUP Transcription Factor II; COUP Transcription Factors; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Oncostatin M; Peptides; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured

Topics: Apoptosis; Butadienes; Concanavalin A; Enzyme Inhibitors; fas Receptor; Flavonoids; Humans; In Situ Nick-End Labeling; Jurkat Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate

Topics: Blood Platelets; Butadienes; Collagen; Enzyme Inhibitors; Humans; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Nitriles; Platelet Aggregation; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate; Thrombin

Topics: Animals; Butadienes; Cell Differentiation; Cell Size; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Mesoderm; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Myosin Heavy Chains; Nitriles; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate; Transcription Factors; Xenopus Proteins

Topics: Animals; Anthocyanins; Anthracenes; Anticarcinogenic Agents; Butadienes; Cell Transformation, Neoplastic; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Structure-Activity Relationship; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

Topics: Animals; Blastocyst; Blotting, Western; Butadienes; Cell Polarity; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Interferon-gamma; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pregnancy; Swine; Tetradecanoylphorbol Acetate

Topics: Blotting, Western; Butadienes; Carbazoles; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Humans; Indoles; Luciferases; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad6 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation

Topics: Animals; Butadienes; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cyclin D1; Disease Susceptibility; DNA, Complementary; Epidermal Cells; Epidermis; Gene Expression Profiling; Genes, jun; HMGA1a Protein; HMGA1b Protein; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Oligonucleotide Array Sequence Analysis; Oligonucleotides, Antisense; Osteopontin; Proto-Oncogene Proteins c-jun; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic

Topics: Anthracenes; Antineoplastic Agents; Butadienes; Cell Line, Tumor; Collagenases; Enzyme Activation; Enzyme Precursors; Flavones; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; raf Kinases; ras Proteins; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1

Topics: Androstadienes; Animals; Butadienes; Carcinogens; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ghrelin; Indoles; Maleimides; MAP Kinase Signaling System; Nitriles; Peptide Hormones; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pituitary Gland; Pituitary Neoplasms; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrphostins; Wortmannin

Topics: Animals; Butadienes; Calcimycin; Calcium; CDC2 Protein Kinase; Female; Ionophores; Male; Mitogen-Activated Protein Kinases; Nitriles; Oocytes; Protein Kinase Inhibitors; Sperm Injections, Intracytoplasmic; Swine; Tetradecanoylphorbol Acetate; Time Factors

Topics: Acetophenones; Astrocytes; Benzopyrans; Blotting, Western; Butadienes; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Immunoprecipitation; Models, Biological; Nitriles; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; RNA, Small Interfering; src-Family Kinases; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Transcriptional Activation; Tyrosine

Topics: Antibodies, Monoclonal; Blotting, Western; Butadienes; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Galectin 1; Gene Expression Regulation; Humans; Imidazoles; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; src-Family Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation

Topics: Anoikis; Apoptosis; Butadienes; Carbazoles; Cell Adhesion; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Indoles; Melanocytes; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection

Topics: ADAM Proteins; ADAM17 Protein; Amino Acid Chloromethyl Ketones; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Blotting, Western; Butadienes; Calcium; Cell Line, Tumor; Central Nervous System; Chelating Agents; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Endopeptidases; Furin; Humans; Indoles; Maleimides; MAP Kinase Signaling System; Metalloendopeptidases; Nitriles; Phorbol Esters; Protein Kinase C; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Uridine Triphosphate

Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases

Topics: Androstenedione; Animals; Butadienes; Cattle; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblast Growth Factor 2; Isoquinolines; Luteinizing Hormone; Nitriles; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Progesterone; Protein Kinase Inhibitors; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Sulfonamides; Tetradecanoylphorbol Acetate; Theca Cells

Topics: Butadienes; Cell Line, Tumor; Doxycycline; Genes, p53; Humans; Leupeptins; Lovastatin; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Nitriles; Proteasome Inhibitors; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins p21(ras); RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p14ARF

Topics: Animals; Antineoplastic Agents; Axotomy; Brain-Derived Neurotrophic Factor; Bryostatins; Butadienes; Cell Survival; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Macrolides; Morpholines; Nerve Growth Factors; Nerve Regeneration; Neurons; Neuroprotective Agents; Neurotrophin 3; Nitriles; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar; Spiral Ganglion; Tetradecanoylphorbol Acetate

Topics: Biomarkers; Butadienes; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; MyoD Protein; Myogenin; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenotype; Rhabdomyosarcoma; Tetradecanoylphorbol Acetate; Transcription, Genetic

Topics: Alanine; Amino Acid Sequence; Animals; Aspartic Acid; Butadienes; Cell Line; Cell Nucleus; Cholesterol 7-alpha-Hydroxylase; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; HeLa Cells; Humans; Ligands; MAP Kinase Signaling System; Mitogens; Molecular Sequence Data; Mutation; Nitriles; Phosphoproteins; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, Cytoplasmic and Nuclear; RNA Splicing Factors; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection

Topics: 3T3 Cells; Alanine; Animals; Butadienes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Janus Kinase 2; MAP Kinase Kinase 1; Mass Spectrometry; Mice; Mutation; Nitriles; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Repressor Proteins; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate

Topics: Butadienes; Chromosomal Instability; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; G2 Phase; HeLa Cells; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; Mitosis; Nitriles; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Apoptosis; Butadienes; Caspase 3; Cell Line, Tumor; Cell Nucleus; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Mitogen-Activated Protein Kinase 1; Nitriles; Ovarian Neoplasms; Phosphorylation; Tetradecanoylphorbol Acetate

Topics: Blotting, Western; Butadienes; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intercellular Adhesion Molecule-1; Leukemia, Myeloid; Maleimides; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Nitriles; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Sulfones; Tetradecanoylphorbol Acetate

Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Butadienes; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Humans; K562 Cells; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitoxantrone; Nitriles; RNA, Small Interfering; Signal Transduction; SUMO-1 Protein; Tetradecanoylphorbol Acetate; Transfection

Topics: Animals; Blotting, Western; Bucladesine; Butadienes; Cell Line, Tumor; Chorionic Gonadotropin; Cyclic AMP-Dependent Protein Kinases; DAX-1 Orphan Nuclear Receptor; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Isoquinolines; Leydig Cells; Male; Mice; Nitriles; Phosphoproteins; Phosphorylation; Progesterone; Protein Kinase C; Receptors, Retinoic Acid; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class B; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate

Topics: 3T3 Cells; Animals; Butadienes; Calcium-Binding Proteins; Colforsin; Cyclic AMP-Dependent Protein Kinases; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Indoles; Isoquinolines; Maleimides; Matrix Gla Protein; Mice; Nitriles; Osteoblasts; Parathyroid Hormone; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate

Topics: Animals; Biomphalaria; Butadienes; Cells, Cultured; Hematopoiesis; Hemocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate

Topics: Antibodies; Antigens, Neoplasm; Benzenesulfonates; Butadienes; CD28 Antigens; CD3 Complex; Epitopes; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Niacinamide; Nitriles; Phenylurea Compounds; Phosphorylation; Phytohemagglutinins; Protein Kinase Inhibitors; Pyridines; Receptors, Antigen, T-Cell; Signal Transduction; Sorafenib; T-Lymphocytes; Tetradecanoylphorbol Acetate

Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Butadienes; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2; Down-Regulation; Humans; MAP Kinase Kinase Kinases; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Nitriles; Phytotherapy; Protein Kinase Inhibitors; Pyrazoles; Seeds; Silybin; Silybum marianum; Silymarin; Sulfonamides; Tetradecanoylphorbol Acetate

Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Butadienes; Cell Survival; Cells, Cultured; Enzyme Activation; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Thymus Gland

Topics: Blotting, Western; Butadienes; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; HEK293 Cells; Humans; MAP Kinase Kinase 1; Nitriles; Protein Binding; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1

Topics: Amino Acid Substitution; Angiotensin II; Animals; Butadienes; Carcinogens; Cell Membrane; Cytosol; Endothelium; Enzyme Activation; Enzyme Inhibitors; Lung; Macrophages, Alveolar; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase Kinases; Mutation, Missense; NADPH Oxidase 2; NADPH Oxidases; Neuropeptides; Nitriles; Peroxiredoxin VI; Phospholipases A2; Phosphorylation; Protein Transport; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Reactive Oxygen Species; Tetradecanoylphorbol Acetate

Topics: Butadienes; Chromatin; Chromones; Cyclin T; Cyclin-Dependent Kinase 9; Extracellular Signal-Regulated MAP Kinases; HIV; Humans; Jurkat Cells; Kinetics; Morpholines; NFATC Transcription Factors; Nitriles; Positive Transcriptional Elongation Factor B; Protein Binding; Proviruses; Receptors, Antigen, T-Cell; Ribonucleoproteins; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Virus Activation; Virus Latency

Topics: Breast Neoplasms; Butadienes; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Nitriles; Phosphorylation; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53

Topics: Butadienes; Cell Differentiation; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Indoles; Macrophages; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NADPH Oxidases; Nitriles; Protein Kinase C; Reactive Oxygen Species; Superoxide Dismutase; Tetradecanoylphorbol Acetate

Topics: Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MAP Kinase Signaling System; NADPH Oxidases; Neutrophils; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate

Topics: Blotting, Western; Butadienes; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; HCT116 Cells; HT29 Cells; Humans; MAP Kinase Signaling System; Nitriles; Phosphorylation; Predictive Value of Tests; Reproducibility of Results; Tetradecanoylphorbol Acetate

Topics: Breast Neoplasms; Butadienes; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Nitriles; Phosphorylation; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Thyroid Neoplasms

Topics: Antibodies; Butadienes; Cell Adhesion; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Integrin alphaV; Intercellular Adhesion Molecule-1; Interferon-gamma; Monocytes; NF-kappa B; Nitriles; Phosphorylation; Signal Transduction; Sulfones; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Female; Flavonoids; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; MCF-7 Cells; Nitriles; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Tetradecanoylphorbol Acetate

Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Butadienes; Cell Membrane; Chromones; HEK293 Cells; Humans; Interleukin-6; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Translocation, Genetic; Wortmannin

Topics: Alternative Splicing; Binding Sites; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Codon, Initiator; Cytoskeletal Proteins; DNA; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Up-Regulation

Topics: Butadienes; Cell Differentiation; Cytokines; Decidua; Endometritis; Enzyme Inhibitors; Female; Hormone Antagonists; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophages; Medroxyprogesterone Acetate; Mifepristone; Monocytes; Nitric Oxide Synthase Type II; Nitriles; Pregnancy; Primary Cell Culture; Stromal Cells; Tetradecanoylphorbol Acetate; THP-1 Cells; Trophoblasts

Topics: Breast Neoplasms; Butadienes; Drug Resistance, Neoplasm; Female; Fibronectins; Furans; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53

Topics: Animals; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Protein Kinase C-alpha; Pulmonary Artery; Rats; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Up-Regulation

Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2