tetradecanoylphorbol acetate has been researched along with tyrosine in 421 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (9.74) | 18.7374 |
| 1990's | 281 (66.75) | 18.2507 |
| 2000's | 91 (21.62) | 29.6817 |
| 2010's | 8 (1.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bailey, TL; Burns, C; McVicar, DW; O'Shea, JJ; Smyth, MJ | 1 |
| Goldstein, BJ; Hashimoto, N | 1 |
| Jung, G; Lieberknecht, A; Metzger, JW; Offermanns, S; Schmidt, U; Schultz, G; Seifert, R | 1 |
| Adams, PD; Parker, PJ | 1 |
| Becker, EL; Gomez-Cambronero, J; Gomez-Cambronero, TM; Huang, CK; Sha'afi, RI; Waterman, WH | 1 |
| Sung, CK | 1 |
| Gallin, JI; Nath, J; Ohno, Y; Wright, DG | 1 |
| Min, HK; Park, DJ; Rhee, SG | 1 |
| Fletcher, MC; Freeman, GJ; June, CH; Kamoun, M; Ledbetter, JA; Nadler, LM; Thompson, CB; Turka, LA; Vandenberghe, P | 1 |
| Bierer, BE; Calvo, V; Crews, CM; Vik, TA | 1 |
| Buschauer, A; Höer, A; Offermanns, S; Schunack, W; Seifert, R | 1 |
| Broxmeyer, HE; Hendrie, PC; Kim, YJ; Kwon, BS; Mantel, C; Miyazawa, K; Yang, YC | 1 |
| Enberg, B; Hansson, A; Lobie, PE; Möller, C; Norstedt, G | 1 |
| Grosmaire, L; Kanner, SB; Ledbetter, JA; Masewicz, S; Odum, N; Svejgaard, A | 1 |
| Atkinson, TP; Cenciarelli, C; Gusovsky, F; Hohman, RJ; Weissman, AM | 1 |
| Bongarzone, I; Borrello, MG; Della Porta, G; Fusco, A; Gambetta, RA; Grieco, M; Lanzi, C; Migliazza, A; Santoro, M; Zunino, F | 1 |
| Burroughs, S; Feinstein, MB; Huang, CK; Lau, LF; Pumiglia, KM | 1 |
| Boulton, TG; Cobb, MH; Geppert, TD; Whitehurst, CE | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Guerin, MC; Slaoui-Hasnaoui, A; Torreilles, J | 1 |
| Chao, W; Hanahan, DJ; Liu, H; Olson, MS | 1 |
| Asplund, T; Heldin, P; Laurent, TC; Thelin, S; Ytterberg, D | 1 |
| Berkow, RL | 1 |
| Bachelot, C; Cano, E; Druker, BJ; Fischer, S; Grelac, F; Levy-Toledano, S; Rendu, F; Saleun, S | 1 |
| Kantorski, J; Tchórzewski, H | 1 |
| Charbonneau, H; Stover, DR; Tonks, NK; Walsh, KA | 1 |
| Casillas, A; Hanekom, C; Katz, R; Nel, AE; Williams, K | 1 |
| Akanuma, Y; Gotoh, Y; Hara, K; Kadowaki, T; Koshio, O; Momomura, K; Nishida, E; Tamemoto, H; Tobe, K; Ueki, K | 1 |
| Bird, TA; Saklatvala, J | 1 |
| Dotto, GP; Filvaroff, E; Stern, DF | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Clark, EA; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| Berkow, RL; Dodson, RW | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Benhamou, M; Gutkind, JS; Robbins, KC; Siraganian, RP | 1 |
| Abraham, RT; Dick, CJ; Einspahr, KJ; Leibson, PJ | 1 |
| Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Jeffs, RA; Outlaw, HE; Rhee, SG | 1 |
| Farrar, WL; Linnekin, D | 1 |
| Hirai, M; Shimizu, N | 1 |
| Clark, EA; Deans, J; Draves, K; Lane, PJ; Ledbetter, JA; McConnell, FM; Schieven, GL | 1 |
| Huber, BT; Muñoz, E; Zubiaga, AM | 1 |
| Alitalo, K; Comoglio, PM; Di Renzo, MF; Koskinen, P; Lehtola, L; Lehväslaiho, H; Sistonen, L | 1 |
| Chin, K; Gazit, A; Gilon, C; Levitzki, A; Mills, GB; Roifman, CM | 1 |
| DeFranco, AL; Gold, MR; Weinstein, SL | 1 |
| Furuya, W; Grinstein, S | 1 |
| Conklyn, MJ; Connelly, PA; Farrell, CA; Merenda, JM; Showell, HJ | 1 |
| Budnik, LT; Mukhopadhyay, AK | 1 |
| Faller, DV; Mundschau, LJ; Quiñones, MA; Rake, JB | 1 |
| Hanekom, C; Hultin, L; Nel, AE | 1 |
| Farrar, WL; Linnekin, D; Willette-Brown, J | 1 |
| Kessler, TL; Markus, G | 1 |
| Dasgupta, JD; Granja, C; Lin, LL; Relias, V; Yunis, EJ | 1 |
| Cannistra, SA; DiCarlo, J; Druker, B; Griffin, JD; Kanakura, Y | 1 |
| Brautigan, DL; Clark, EA; Gallis, B; Ledbetter, JA; Pinault, F; Valentine, MA; Voice, R; Widmer, MB | 1 |
| Kiekens, R; Pipeleers, DG; Schuit, FC | 1 |
| Bowen, S; Davis, RJ; Selva, E; Stanley, K | 1 |
| Beckwith, M; Ferris, DK; Freter, CE; Kuhns, DB; Longo, DL; Moratz, CM; Urba, WJ | 1 |
| Leeb-Lundberg, LM; Song, XH | 1 |
| Ishida, Y; Kawahara, Y; Koide, M; Shii, K; Tsuda, T; Yokoyama, M | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Bussolino, F; Comoglio, PM; Di Renzo, MF; Gandino, L; Giordano, S | 1 |
| Gottlieb, RA; Jiang, WP; Kinsey, WH; Lennarz, WJ | 1 |
| Akerley, B; Hultin, L; Katz, R; Landreth, G; Ledbetter, JA; Nel, AE; Pollack, S; Williams, K | 1 |
| Agrawal, D; Agrawal, HC; Sprinkle, TJ | 1 |
| Hirai, M; Kobayashi, M; Shimizu, N | 1 |
| Bonak, VA; Caon, AC; Gaudry, M; Gilbert, C; Huang, CK; McColl, SR; Naccache, PH; Umezawa, K | 1 |
| Chakravarthy, B; Durkin, JP; Franks, DJ; Mealing, G; Schwartz, JL; Tremblay, R; Whitfield, JF | 1 |
| Bulgarina, TV; Kharitonenkov, AI | 1 |
| Kitani, T; Kuratsune, H; Machii, T; Morita, T; Nishimori, Y; Nojima, J; Owada, MK; Shibano, M; Tagawa, S; Tokumine, Y | 1 |
| Capeau, J; Caron, M; Cherqui, G; Clauser, E; Melin, B; Picard, J; Reynet, C; Wicek, D | 1 |
| Baker, M; Fung, M; Greene, WC; May, C; McGill, M; Mills, GB; Sutherland, R | 1 |
| Mueller-Lantzsch, N; Roeckel, D | 1 |
| Ishihara, N; Kobayashi, B; Nagao, K | 1 |
| Casnellie, JE; Lamberts, RJ | 1 |
| Benjamin, TL; Matthews, JT | 1 |
| Comoglio, PM; Meldolesi, J; Pandiella-Alonso, A; Sturani, E; Toschi, L; Vicentini, LM; Zippel, R | 1 |
| Chinkers, M; Garbers, DL | 1 |
| Harford, JB; Klausner, RD; Patel, MD; Samelson, LE; Weissman, AM | 1 |
| Brown, KD; Gould, KL; Gould, SJ; Hunter, T; Isacke, CM; Meisenhelder, J | 1 |
| Bass, G; Wedner, HJ | 1 |
| Dull, TJ; Kahn, CR; Stegmann, EW; Ullrich, A; White, MF | 1 |
| Cooper, JA; Kazlauskas, A | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Brugge, JS; Golden, A | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Casnellie, JE; Thom, RE | 1 |
| Farrar, WL; Ferris, DK; Martensen, T; Willette-Brown, J | 1 |
| Decker, SJ; Harris, P | 1 |
| Bonak, VA; Casnellie, JE; Gomez-Cambronero, J; Huang, CK; Sha'afi, RI; Shiraishi, T; Wang, E | 1 |
| Arai, K; Collins, M; Miyajima, A; Wang, HM | 1 |
| Nath, J; Powledge, A; Wright, DG | 1 |
| Kuklinska, E; Moellmann, G; Slominski, A | 1 |
| Krystal, G; Mui, AL; Murthy, SC; Sorensen, PH | 1 |
| Friedman, E; Marian, B; Winawer, S | 1 |
| Cohen, B; Druker, B; Kaplan, D; Keller, T; Mamon, H; Morgan, W; Piwnica-Worms, H; Roberts, TM; Schaffhausen, B; Whitman, M | 1 |
| Houchi, H; Nakanishi, A; Ohuchi, T; Oka, M; Uddin, MM | 1 |
| Boynton, AL; Raptis, L; Whitfield, JF | 1 |
| Cooper, JA; King, CS | 1 |
| Hoffbrand, AV; Mire, AR; Wickremasinghe, RG | 1 |
| Hachiya, HL; King, GL; Takayama, S; White, MF | 1 |
| Houchi, H; Misbahuddin, M; Morita, K; Nakanishi, A; Oka, M | 1 |
| Kahn, CR; Takayama, S; White, MF | 1 |
| Vila, J; Weber, MJ | 1 |
| Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Kohno, M | 1 |
| Baldwin, GJ; Galbraith, RM; Goldschmidt-Clermont, PJ; Landreth, GE; Navailles, M; Nel, AE; Rosberger, DF | 1 |
| Houchi, H | 1 |
| Bissell, MJ; Chin, S; Laszlo, A; Radke, K | 1 |
| Gorden, P; Grunberger, G; Taylor, SI; Zick, Y | 1 |
| Decker, SJ | 1 |
| King, AC; Moon, SO; Palfrey, HC | 1 |
| Bishop, R; Martinez, R; Nakamura, KD; Weber, MJ | 1 |
| Giasson, E; Haddad, P; Leduc, I; Meloche, S | 1 |
| Seedorf, K; Sherman, M; Ullrich, A | 1 |
| Oliver, JM; Pfeiffer, JR | 1 |
| Baccarini, M; Decker, T; Eilers, A; Hipskind, RA; Horn, F; Schindler, C | 1 |
| Heidaran, MA; Li, W; Mischak, H; Mushinski, JF; Pierce, JH; Wang, LM; Yu, JC | 1 |
| Errasfa, M; Stern, A | 2 |
| Berti, L; Häring, H; Kellerer, M; Kroder, G; Mosthaf, L; Mushack, J; Seedorf, K; Seffer, E; Tippmer, S | 1 |
| Hirota, K; Kanda, Y; Koike, K; Miyake, A; Ohmichi, M; Saltiel, AR; Sawada, T | 1 |
| Breitbart, H; Lax, Y; Rubinstein, S | 1 |
| Pratt, MM; Salathe, M; Wanner, A | 1 |
| Gould, GW; Merrall, NW; Plevin, RJ | 1 |
| Hajjar, DP; Hsu, HY; Nicholson, AC | 1 |
| Anel, A; Kleinfeld, AM; Richieri, GV | 1 |
| Hurme, M; Matikainen, S | 1 |
| Chin, JE; Liu, F; Roth, RA | 1 |
| Bierer, BE; Hutchcroft, JE | 1 |
| Kahn, CR; Kim, SJ | 1 |
| Liu, F; Roth, RA | 1 |
| Falet, H; Rendu, F | 1 |
| Dubois, PM; Herndon, V; Kiener, PA; Klussman, K; Mittler, RS; O'Connell, MP; Schieven, GL | 1 |
| Berridge, MJ; Bootman, MD; Jenkins, AL; Stone, SR | 1 |
| Gupta, S; Kumar, G; Nel, A; Wang, S; Weiss, A | 1 |
| Hall, A; Ridley, AJ | 1 |
| Gschwendt, M; Kielbassa, K; Kittstein, W; Marks, F | 1 |
| Gould, GW; Graham, A; Malarkey, K; Paterson, A; Plevin, R; Saville, MK | 1 |
| Berton, G; Fumagalli, L; Laudanna, C; Sorio, C | 1 |
| Hattori, S; Katagiri, K; Katagiri, T; Nakamura, S; Yamamoto, T; Yoshida, T | 1 |
| Pfefferkorn, LC; Yeaman, GR | 1 |
| Izumi, H; Kohno, K; Kung, HF; Kuwano, M; Ono, M; Ushiro, S | 1 |
| Abboud, HE; Choudhury, GG; Fouqueray, B; Kiyomoto, H | 1 |
| Herberman, RB; Lin, WC; Rabinowich, H; Whiteside, TL | 1 |
| Hefti, F; Isono, F; Knüsel, B; Widmer, HR | 1 |
| Bayna, EM; Cheresh, DA; Klemke, RL; Yebra, M | 1 |
| Anderson, MT; Gitler, C; Herzenberg, LA; Staal, FJ | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Besmer, P; Hsiau, CW; Serve, H; Vosseller, K; Yee, NS | 1 |
| Bissell, MJ; Desprez, PY; Roskelley, CD | 1 |
| Cherqui, G; Plas, C; Zachayus, JL | 1 |
| Abu-Lawi, KI; Sultzer, BM | 2 |
| Garcia-Welsh, A; Laskin, DL; Laskin, JD; Molloy, CJ | 1 |
| Andersson, T; Eierman, D; Hellberg, C; Sjölander, A | 1 |
| Hundle, B; Messing, RO; Roivainen, R | 1 |
| Fernandez, A; Kiefer, J; McConkey, DJ; Neamati, N; Wright, S | 1 |
| Felder, MP; Hanafusa, H; Scholz, G | 1 |
| Kim, G; Yurkow, EJ | 1 |
| Hunter, T; Tracy, S; van der Geer, P | 1 |
| Brondello, JM; McKenzie, FR; Pouysségur, J; Rivard, N | 1 |
| Molloy, CJ; Pietras, KM; Taylor, DS; Turner, CE | 1 |
| Hardwick, JS; Sefton, BM | 1 |
| Mahon, TM; O'Neill, LA | 1 |
| Nakamura, S; Nishizuka, Y; Ogita, K; Yamaguchi, K | 1 |
| Soltoff, SP; Toker, A | 1 |
| Adachi, K; Asano, H; Hamaguchi, M; Ito, T; Koizumi, KT; Murate, T; Saga, S; Saito, H; Watanabe, T; Yoshida, S | 1 |
| Pollock, AS; Santiesteban, HL | 1 |
| Druker, BJ; Emmerich, B; Goodwin, RG; Gruss, HJ; Hallek, M; Schmitt, B; Wendtner, CM | 1 |
| Danielsen, AG; Hosomi, Y; Liu, F; Roth, RA; Shii, K | 1 |
| Berenstein, EH; Siraganian, RP; Swaim, WD; Swieter, M | 1 |
| Chen, M; Hay, N; Kim, S; Li, W; Rockow, S; Wagner, AJ; Weichselbaum, RR; Xu, J; Yi, SE | 1 |
| Jones, PM; Persaud, SJ; Wheeler-Jones, CP | 1 |
| Gould, GW; Graham, A; Malarkey, K; McLees, A; Plevin, R | 2 |
| Druker, B; Hallek, M; Pignata, C; Prasad, KV; Ritz, J; Robertson, MJ; Rudd, CE | 1 |
| Blumberg, PM; Chang, EY; Haleem-Smith, H; Rivera, J; Szallasi, Z | 1 |
| Antoine, PJ; Baud, L; Bertrand, F; Capeau, J; Cherqui, G; Groyer, A; Philippe, C | 1 |
| Bhat, NR; Hogan, EL; Zhang, P | 1 |
| Kajiyama, K; Katagiri, K; Katagiri, T; Yamamoto, T; Yoshida, T | 1 |
| Bos, JL; Hordijk, PL; Medema, RH; Moolenaar, WH; van Corven, EJ | 1 |
| Ploegh, HL; Schaap, D; van Blitterswijk, WJ; van der Bend, RL; van der Wal, J | 1 |
| Bombien, E; Offermanns, S; Schultz, G | 2 |
| Kobuchi, H; Kurashige, T; Minakami, K; Miyahara, M; Utsumi, K; Watanabe, Y | 1 |
| Golde, DW; Kolesnick, RN; Raines, MA | 1 |
| Bongrand, P; Bouhamdan, M; Capo, C; Huang, CK; Mege, JL; Sanguedolce, MV | 1 |
| Bell, SM; Connolly, DC; Degen, JL; Maihle, NJ | 1 |
| Nishimura, H; Simpson, IA; Zarnowski, MJ | 1 |
| Kellie, S; Murphy, CT; Westwick, J | 1 |
| Ruoslahti, E; Vuori, K | 1 |
| Dombrádi, V; Ferber, E; Gergely, P; Goldman, R; Szücs, K; Zor, U | 1 |
| Broxmeyer, HE; Horie, M; Yip-Schneider, MT | 1 |
| Breu, J; Petryniak, MA; Slack, BE; Srivastava, K; Wurtman, RJ | 1 |
| Robinson, JM; Vandré, DD | 1 |
| Chap, H; Gaits, F; Li, RY; Ragab, A; Ragab-Thomas, JM | 1 |
| Ali, S; Dorn, GW | 1 |
| Hosomi, Y; Ogawa, W; Roth, RA | 1 |
| Abboud, HE; Biswas, P; Choudhury, GG; Fouqueray, B; Grandaliano, G; Wenzel, UO | 1 |
| Adler, WH; Chung, S; Collins, GD; Kim, YH; Nagel, JE; Song, L; TenBrook, J | 1 |
| Cerione, RA; Gamett, DC | 1 |
| Leeb-Lundberg, LM; Mathis, SA; Song, XH | 1 |
| Duan, RD; Williams, JA | 1 |
| Fasselt, B; Homann, D; Hüwe, SM; Jakobs, KH; Rümenapp, U; Sandmann, J; Schmidt, M | 1 |
| Bjorndahl, JM; Lu, Y; Phillips, CA; Trevillyan, JM | 1 |
| Izumo, S; Morgan, JP; Qiu, Z; Sadoshima, J | 1 |
| Asano, Y; Enomoto, T | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Leslie, CC; Qiu, ZH | 1 |
| Jalava, A; Mai, S | 1 |
| Boissy, R; Farooqui, J; Matsumoto, K; Medrano, EE; Nordlund, JJ; Park, HY; Shah, V; Yang, F | 1 |
| Bowtell, D; Duronio, V; Leslie, KB; Schrader, JW; Welham, MJ | 1 |
| Alexander, RW; Griendling, KK; Kai, H; Lassègue, B; Ollerenshaw, JD; Runge, MS | 1 |
| Báez, I; Breithaupt, TB; Eylar, EH; Molina, C; Rivera-Quiñones, C | 1 |
| Aussel, C; Bernard, A; Breittmayer, JP; Deckert, M | 1 |
| Connelly, PA; Farrell, CA; Richard, S; Shaw, AS; Showell, HJ | 1 |
| Arai, T; Matsui, K | 2 |
| Chen, EY; Giaccia, AJ; Koong, AC | 1 |
| Lin, CT; Shen, Z; Unkeless, JC | 1 |
| Capeau, J; Caron, M; Cherqui, G; Picard, J; Reynet, C; Wicek, D | 1 |
| Azuma, EK; Kitagawa, S; Mizoguchi, H; Saito, M; Takaku, F; Umezawa, K; Yuo, A | 1 |
| Denning, M; Lee, E; Li, L; Punnonen, K; Rhee, SG; Yuspa, SH | 1 |
| Egan, SE; Goldberg, HJ; Hack, N; Skorecki, KL; Warner, LC; Weinberg, RA | 1 |
| Rabgaoui, N; Salman-Tabcheh, S; Torreilles, J | 1 |
| Chatani, Y; Kohno, M; Miyoshi, N; Nakamura, M; Nakashima, S; Nozawa, Y | 1 |
| Cazaubon, S; Couraud, PO; Parker, PJ; Strosberg, AD | 1 |
| Fürstenberger, G; Kast, R; Marks, F | 1 |
| Decker, SJ; Pang, L; Saltiel, AR | 1 |
| Rieber, M; Rieber, MS | 1 |
| Cambier, JC; Harwood, AE | 1 |
| Hamawy, MM; Mergenhagen, SE; Siraganian, RP | 2 |
| Amaral, K; Casillas, AM; Chegini-Farahani, S; Nel, AE | 1 |
| Delovitch, TL; Jaramillo, A; Lazarus, AH; Rapoport, MJ; Speck, E | 1 |
| Kolattukudy, PE; Li, YS; Shyy, YJ | 1 |
| Jacobson, K; Lin, CT; Odin, JA; Shen, Z; Unkeless, JC; Yang, B; Zhang, F | 1 |
| Burns, DM; Kawase, T; Ogata, S; Orikasa, M | 1 |
| Guérin, MC; Salman-Tabcheh, S; Torreilles, J | 1 |
| Brogi, E; Couffinhal, T; Isner, JM; Kearney, M; Kim, EA; Namiki, A; Varticovski, L; Wu, T | 1 |
| Haimovich, B; Ji, P; Kaneshiki, N | 1 |
| Bhatia, M; Kirkland, JB; Meckling-Gill, KA | 1 |
| Rawadi, G; Roman-Roman, S | 1 |
| Davis, LS; Hashimoto, K; Lipsky, PE; Tao, X | 1 |
| Huijzer, JC; McFarland, M; Meadows, GG; Niles, RM | 1 |
| Ahn, JS; Ahn, SC; Kang, DO; Kim, BY; Ko, HR; Lee, HS; Mheen, TI; Oh, WK; Rho, HM | 1 |
| Berton, G; Fumagalli, L; Yan, SR | 1 |
| Koga, Y; Kubo, C; Nomoto, K; Okumura, Y; Sudo, N; Tanaka, K | 1 |
| Kinsey, WH | 1 |
| Kurosaki, T; Maruyama, S; Sada, K; Yamamoto, T; Yamamura, H; Yamanashi, Y | 1 |
| Chang, EY; Fewtrell, C; Rivera, J; Wolfe, PC | 1 |
| Billestrup, N; Carter-Su, C; King, AP; Logsdon, CD; Tseng, MJ | 1 |
| Tseng, CP; Verma, AK | 1 |
| Ogihara, S; Rokutan, K; Saito, T; Shono, M; Yamada, M | 1 |
| Auberger, P; Baeuerle, PA; Farahifar, D; Imbert, V; Livolsi, A; Mueller-Dieckmann, C; Pahl, HL; Peyron, JF; Rossi, B; Rupec, RA; Traenckner, EB | 1 |
| Matsui, K | 1 |
| Alonso, A; Bayón, Y; Crespo, MS | 1 |
| Alimandi, M; Bottaro, DP; Chen, Q; Chen, XH; Kelley, CA; Li, W; Pierce, JH; Zhang, J | 1 |
| Long, BW; Oberyszyn, TM; Robertson, FM; Ross, MS; Tober, KL | 1 |
| Lee, SC; Yang, SD | 1 |
| Buckley, AR; Buckley, DJ; Rao, YP | 1 |
| Donini, M; Dusi, S; Rossi, F; Wientjes, F | 1 |
| Bajpai, A; Brahmi, Z | 1 |
| Kettle, AJ; Pichorner, H; Winterbourn, CC | 1 |
| Altman, A; Elly, C; Lipkowitz, S; Liu, Y; Liu, YC; Yoshida, H | 1 |
| Miszta-Lane, H; Murat, J; Radomski, MW; Salas, E; Sawicki, G | 1 |
| Darzynkiewicz, Z; Finger, LR; Juan, G; Traganos, F; Vibhakar, R | 1 |
| Appella, E; Kimura, T; Sakamoto, H; Siraganian, RP | 1 |
| Buday, L; Kapus, A; Szászi, K | 1 |
| Bass, BL; Summers, ST | 1 |
| Banick, PD; Chen, Q; Thom, SR; Xu, YA | 1 |
| Daulhac, L; Kowalski-Chauvel, A; Pradayrol, L; Seva, C; Vaysse, N | 1 |
| Meighan-Mantha, RL; Riegel, AT; Wellstein, A | 1 |
| Boquet, P; Defilippi, P; Duperray, A; Fiorentini, C; Gulino, D; Palmieri, M; Silengo, L; Tarone, G; Venturino, M; Volpe, G | 1 |
| García, LJ; González, A; Jensen, RT; Rosado, JA | 1 |
| Carrero, A; Curto, M; Foster, DA; Frankel, P | 1 |
| Houghton, PJ; Luo, W; Sharif, M; Sharif, TR | 1 |
| Emkey, R; Kahn, CR | 2 |
| De Fea, K; Roth, RA | 1 |
| Craig, R; Harlan, JM; Karsan, A; Poirier, GG; Yee, E; Zhou, P | 1 |
| Herrera-Velit, P; Hmama, Z; Knutson, KL; Reiner, NE; Rochford, R | 1 |
| Avraham, H; Avraham, S; Cantley, LC; Soltoff, SP | 1 |
| Aboulafia-Etzion, S; Aharonovitz, O; Battler, A; Granot, Y; Leor, J | 1 |
| Kuan, CY; Lee, SC; Wen, ZD; Yang, SD | 1 |
| Polk, DB | 1 |
| Dugué, B; Ekokoski, E; Törnquist, K | 1 |
| Baldi, E; Bonaccorsi, L; Forti, G; Krausz, C; Pecchioli, P | 1 |
| Hunzicker-Dunn, M; Kawakatsu, H; Krett, NL; Maizels, ET; Murad, FM; Peters, CA; Rosen, ST; Shanmugam, M | 1 |
| de Boland, AR; Norman, AW | 1 |
| Chen, DB; Davis, JS; Fong, HW; Roberson, MS; Westfall, SD | 1 |
| Garcia, LJ; Jensen, RT; Rosado, JA; Salido, GM | 1 |
| Ansorge, S; Faust, J; Kähne, T; Neubert, K | 1 |
| Dunsmore, SE; Matrisian, LM; Parks, WC; Roby, JD; Saarialho-Kere, UK; Welgus, HG; Wilson, CL | 1 |
| Barnard, D; Clawson, D; Diaz, B; Marshall, M | 1 |
| Fukuyama, N; Genka, C; Ishida, H; Nakazawa, H; Su, Z; Todorov, R | 1 |
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| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Ahmad, F; Degerman, E; Gao, G; Landstrom, TR; Manganiello, VC; Pierce, JH; Wang, LM | 1 |
| Cooper, RG; Marais, R; Marshall, CJ; Mason, CS; Springer, CJ; Superti-Furga, G | 1 |
| Hanai, H; Kajimura, M; Kaneko, E; Kodaira, M; Lin, S; Takeuchi, K | 1 |
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| Aratani, Y; Kodama, T; Koyama, H; Nakano, K; Niki, E; Noguchi, N | 1 |
| Blumberg, PM; Brodie, C; Garfield, SH; Kazimirsky, G; Kronfeld, I; Lorenzo, PS | 1 |
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| Boczkowski, J; Derkinderen, P; Desmonts, JM; Girault, JA; Jardinaud, F; Juvin, P; Keita, H; Mantz, J; Peyclit, A; Rouellé, D | 1 |
| Ganem, D; Lagunoff, M; Lukac, DM | 1 |
| Hebbar, V; Kim, DW; Kong, AN; Mandlekar, S; Pezzuto, JM; Yu, R | 1 |
| Lass, A; Mayer, B; Pfeiffer, S; Schmidt, K | 1 |
| Chibalin, AV; Féraille, E; Kovalenko, MV; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Sakamoto, S; Taniguchi, T | 1 |
| Caldwell, RB; Catravas, JD; Ehrhart, IC; Gu, X; Parkerson, JB; Theodorakis, MJ; Zou, L | 1 |
| Asaka, Y; Kodama, H; Lu, HW; Manabe, M; Masuoka, N; Sagara, Y; Sugahara, K | 1 |
| Kucik, DF; Li, J; Zhou, X | 1 |
| Byron, KL; Lucchesi, PA | 1 |
| Eckert, A; Fröhlich, L; Maurer, K; Müller, WE; Schindowski, K | 1 |
| Feng, X; Kodama, H; Lu, H; Lu, J; Ma, D; Manabe, M; Sagara, Y; Sugahara, K; Sun, Q | 1 |
| Bryson, JM; Coy, PE; Ma, J; Noboa, OA; Robey, RB; Santos, AV | 1 |
| Ahn, BH; Chang, JS; Choi, JY; Chung, KC; Hahn, SJ; Jo, YH; Kim, MS; Kim, SY; Kwon, TK; Lee, MY; Lee, YH; Min, DS; Rhim, H; Sung, YM; Wolozin, B; Yoon, SH | 1 |
| Baudouin, E; Charpenteau, M; Ranjeva, R; Ranty, B | 1 |
| Brandt, D; Gimona, M; Haller, H; Hillmann, M; Mischak, H | 1 |
| Fujino, H; Regan, JW; Srinivasan, D | 1 |
| Denhez, F; Goetinck, PF; Wilcox-Adelman, SA | 1 |
| Harlan, JM; Lin, N; Liu, L; Schwartz, BR; Tupper, J; Winn, RK | 1 |
| Galiñanes, M; Matata, BM | 1 |
| Luo, Z; Waelde, CA; Wen, R; Xiang, X; Zang, M | 1 |
| Adelmeijer, J; De Groot, PG; Lisman, T; Moschatsis, S; Nieuwenhuis, HK | 1 |
| Chen, G; Kodama, H; Lu, H; Manabe, M; Meng, Z; Wang, C; Xu, S; Yamashita, K | 1 |
| Chen, G; Kodama, H; Lu, H; Manabe, M; Wang, C; Yamashita, K | 1 |
| Huang, C; Huang, Y; Li, J; Luo, J; Ma, C | 1 |
| Bachschmid, M; Cosentino, F; De Paolis, P; Delli Gatti, C; Eto, M; Joch, H; Kouroedov, A; Lüscher, TF; Ullrich, V; van der Loo, B; Volpe, M | 1 |
| Dobashi, H; Ishida, H; Ishida, T; Kitanaka, A; Kubo, A; Kubota, Y; Matsumoto, A; Ohnishi, H; Tanaka, T; Tokuda, M; Waki, M | 1 |
| Berton, G; Bowtell, DD; Caveggion, E; Continolo, S; Lowell, CA; Pixley, FJ; Stanley, ER | 1 |
| Chen, CC; Chen, JJ; Huang, WC; Inoue, H | 1 |
| Idell, S; Shetty, S | 1 |
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| Chen, G; Kitaoka, N; Kodama, H; Lu, H; Manabe, M; Sagara, Y; Song, S; Wang, Z; Xu, S | 1 |
| Baugh, MD; Edwards, DR; Gavrilovic, J; Hogan, A; Hughes, DA; Sampson, MJ; Worley, JR | 1 |
| Namiki, H; Suzuki, K; Takahashi, H | 1 |
| D'Souza, SE; English, WR; Sen, U; Sithu, SD; Tsakadze, NL; Zhao, Z | 1 |
| Chang, YJ; Chen, CC; Holtzman, MJ | 1 |
| Bae, DS; Bae, YS; Ha, KS; Lee, IH; Rhee, SG; Suh, PG; You, JO | 1 |
| Ferris, LC; Mirshahidi, S; Sadegh-Nasseri, S | 1 |
| Freund, GG; Godbout, JP; Hartman, ME; Mazzocco, VR; Minor, KD; O'Connor, JC | 1 |
| Addona, GH; Das, J; Husain, SS; Miller, KW; Sandberg, WS; Stehle, T | 1 |
| Chattopadhyay, S; Kinter, M; McCue, B; Sadhukhan, R; Santhamma, KR; Sen, I | 1 |
| Blagosklonny, MV; Chay, KO; Hashimoto, S; Mushinski, JF; Romanova, LY; Sabe, H | 1 |
| Bouton, C; Drapier, JC; Gonzalez, D | 1 |
| Barki-Harrington, L; El-Shewy, HM; Kelly, FL; Luttrell, LM | 1 |
| Avram, D; Heck, AJ; Pap, EH; Romijn, EP; Wirtz, KW | 1 |
| Dahmani, S; Desmonts, JM; Mantz, J; Rouelle, D; Tesnière, A; Toutant, M | 1 |
| Baisden, JM; Flynn, DC; Gatesman, A; Walker, VG; Weed, SA | 1 |
| Anderson, WB; Kim, JY; Lee, M | 1 |
| Beom, S; Cheong, H; Cho, D; Kim, KM; Kim, S; Oak, M; Yoon, E | 1 |
| Amos, S; Hussaini, IM; Martin, PM; Parsons, SJ; Polar, GA | 1 |
| Cohen, DM | 1 |
| Haneda, M; Li, W; Murakami, K; Nisimoto, Y; Qiao, S; Takeuchi, F; Tsubouchi, R; Yoshino, M | 1 |
| Cohen, G; Kodama, T; Makranz, C; Reichert, F; Rotshenker, S; Spira, M | 1 |
| Kodama, H; Liu, G; Manabe, M; Song, SJ; Yagi-Chaves, SN; Yamashita, K | 1 |
| Baker, HW; Clarke, GN; Liu, DY | 1 |
| Giner, RM; Máñez, S; Olmos, A; Recio, MC; Ríos, JL | 1 |
| Hibino, Y; Hitomi, Y; Ichimura, H; Kamyabashi, Y; Kurosawa, CM; Ogino, K; Takemoto, K; Takigawa, T; Wang, DH | 1 |
| Hall, KJ; Jones, ML; Poole, AW | 1 |
| Abbott, D; Engelhardt, JF; Harraz, MM; Park, A; Zhang, Y; Zhou, W | 1 |
| Benveniste, EN; Ma, Z; Nozell, S; Zhao, X | 1 |
| Castañeda-Patlán, C; García, W; González-Aguilar, H; Lam, TT; Meléndez, L; Mendoza-Hernández, G; Robles-Flores, M | 1 |
| Feinmark, SJ; Gertsberg, Z; Guo, J; Rybin, VO; Steinberg, SF | 1 |
| Gil-Benso, R; Giner, RM; Máñez, S; Olmos, A; Recio, MC; Ríos, JL | 1 |
| Baker, HW; Liu, DY; Liu, ML | 1 |
| Lewandrowski, U; Müller, B; Sickmann, A; Walz, G; Wegierski, T | 1 |
| Appella, E; Ashwell, JD; Mittelstadt, PR; Yamaguchi, H | 1 |
| Bessette, DC; Chen, SC; Khanna, RS; Pallen, CJ; Samayawardhena, LA | 1 |
| Carluccio, MA; De Caterina, R; Distante, A; Massaro, M; Scoditti, E; Storelli, C | 1 |
| Bartos, JA; Beazely, MA; Chen, Y; Hell, JW; Li, H; Macdonald, JF; Ulrich, JD | 1 |
| Amos, S; Hussaini, IM; Mut, M | 1 |
| Brand, C; Brodie, C; Horovitz-Fried, M; Inbar, A; Sampson, SR | 1 |
| Amoruso, A; Arlorio, M; Bardelli, C; Brunelleschi, S; Coisson, JD; Locatelli, M; Travaglia, F; Zeng, H | 1 |
| Baer-Dubowska, W; Cichocki, M; Dałek, M; Szamałek, M | 1 |
| D'Aquino, K; Feener, EP; King, GL; Li, Q; Maeda, Y; Mima, A; Mizutani, K; Park, K; Rask-Madsen, C; White, MF; Winnay, J | 1 |
| Haidari, M; Wakame, K; Zhang, W | 1 |
1 review(s) available for tetradecanoylphorbol acetate and tyrosine
| Article | Year |
|---|---|
TRPV4 and the mammalian kidney.
Topics: Animals; Hot Temperature; Humans; Hypotonic Solutions; Kidney; Kidney Tubules; Lipids; Models, Biological; Phorbol Esters; Tetradecanoylphorbol Acetate; TRPV Cation Channels; Tyrosine; Water-Electrolyte Balance | 2005 |
420 other study(ies) available for tetradecanoylphorbol acetate and tyrosine
| Article | Year |
|---|---|
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Cytosol; Flow Cytometry; Gene Expression Regulation; Humans; Hydrogen Peroxide; Immunoblotting; Kinetics; Lymphocyte Activation; Mice; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Interleukin-2; RNA; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1992 |
Differential regulation of mRNAs encoding three protein-tyrosine phosphatases by insulin and activation of protein kinase C.
Topics: Animals; Culture Media, Serum-Free; Enzyme Activation; Half-Life; Insulin; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tyrosine | 1992 |
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Topics: Blotting, Western; Bucladesine; Cell Differentiation; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Genistein; Humans; Isoflavones; Lipoproteins; Neutrophils; Pertussis Toxin; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1992 |
Activation of mitogen-activated protein (MAP) kinase by a MAP kinase-kinase.
Topics: Adenosine; Autoradiography; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Substrate Specificity; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1992 |
Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of microtubule-associated protein kinase in human neutrophils.
Topics: Amino Acid Sequence; Antibodies; Blood Proteins; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Phosphoproteins; Phosphorylation; Protein Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites.
Topics: Animals; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Humans; Insulin; Kinetics; Mutation; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1992 |
A novel post-translational incorporation of tyrosine into multiple proteins in activated human neutrophils. Correlation with phagocytosis and activation of the NADPH oxidase-mediated respiratory burst.
Topics: Blood Proteins; Cells, Cultured; Edetic Acid; Free Radical Scavengers; Granulomatous Disease, Chronic; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Peroxidase; Phagocytosis; Phagosomes; Protein Processing, Post-Translational; Respiratory Burst; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Inositol Phosphates; Kinetics; Muromonab-CD3; Peptide Mapping; Phosphates; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases; Tyrosine | 1992 |
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
Topics: Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzoquinones; CD28 Antigens; Histocompatibility Antigens; Humans; In Vitro Techniques; Interleukin-2; Lactams, Macrocyclic; Leukocyte Common Antigens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Quinones; Receptor Aggregation; Receptors, Cell Surface; Rifabutin; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1992 |
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Immunoblotting; Immunosuppressive Agents; Interleukin-2; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue.
Topics: Betahistine; Bucladesine; Calcium; Cations; Cell Differentiation; Cytosol; Glucuronidase; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Humans; Ion Channels; Leukemia, Experimental; Leukemia, Myeloid; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Receptors, Histamine H1; Secretory Rate; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Virulence Factors, Bordetella | 1992 |
Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel factor to stimulate proliferation of the human factor-dependent cell line, M07e.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Genistein; Hematopoietic Cell Growth Factors; Humans; Immunoblotting; Interleukin-9; Isoflavones; Kinetics; Phosphoproteins; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Stem Cell Factor; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Cricetinae; DNA; Enzyme Activation; Glycogen Synthase Kinase 3; Growth Hormone; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Kinases; Rats; Receptors, Somatotropin; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transfection; Tyrosine | 1992 |
Superantigen and HLA-DR ligation induce phospholipase-C gamma 1 activation in class II+ T cells.
Topics: Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Enterotoxins; Enzyme Activation; HLA-D Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Phosphotyrosine; Protein-Tyrosine Kinases; Staphylococcus aureus; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1992 |
Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor zeta chain.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanylyl Imidodiphosphate; Mice; Phosphorylation; Receptors, Antigen, T-Cell, gamma-delta; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured; Tyrosine | 1992 |
Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas.
Topics: 3T3 Cells; Animals; Blotting, Western; Carcinoma, Papillary; Drosophila Proteins; Gene Rearrangement; Humans; Mice; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Proto-Oncogenes; Receptor Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Tyrosine | 1992 |
Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide).
Topics: Actins; Adenosine Triphosphate; Alkaloids; Blood Proteins; Blotting, Western; Calcium; Catechols; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Nitriles; Phospholipids; Phosphoproteins; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Tyrosine Phosphatases; Serotonin; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine; Tyrphostins; Vanadates | 1992 |
Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Enzyme Activation; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Reciprocal effects between opioid peptides and human polymorphonuclear leukocytes--I. Chemical modifications of Leu-enkephalin by phorbol myristate acetate-stimulated polymorphonuclear leukocytes.
Topics: Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Humans; Hydroxylation; Luminescent Measurements; Mass Spectrometry; Neutrophils; Peptides; Phenylalanine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Platelet-activating factor-stimulated protein tyrosine phosphorylation and eicosanoid synthesis in rat Kupffer cells. Evidence for calcium-dependent and protein kinase C-dependent and -independent pathways.
Topics: Animals; Blotting, Western; Calcimycin; Calcium; Down-Regulation; Egtazic Acid; Eicosanoids; Electrophoresis, Polyacrylamide Gel; Gallic Acid; Kupffer Cells; Phosphorylation; Platelet Activating Factor; Precipitin Tests; Protein Kinase C; Radioimmunoassay; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Characterization of the molecular mechanism involved in the activation of hyaluronan synthetase by platelet-derived growth factor in human mesothelial cells.
Topics: Cell Membrane; Cells, Cultured; Cycloheximide; Enzyme Activation; Epithelial Cells; Epithelium; Glucuronosyltransferase; Glycosyltransferases; Humans; Hyaluronan Synthases; Kinetics; Membrane Proteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Biosynthesis; Protein Kinase C; Serine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Threonine; Transferases; Transforming Growth Factor beta; Tyrosine; Vanadates; Xenopus Proteins | 1992 |
Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins.
Topics: Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Functional implications of tyrosine protein phosphorylation in platelets. Simultaneous studies with different agonists and inhibitors.
Topics: Blood Platelets; Blood Proteins; Collagen; Disulfides; Humans; In Vitro Techniques; Models, Biological; Oligopeptides; Phosphoproteins; Phosphorylation; Plant Extracts; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase C; Sulfoxides; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1992 |
The effect of serine and thiol protease inhibitors on the chemiluminescence of human neutrophils in investigations in vitro.
Topics: Calcimycin; Cysteine Proteinase Inhibitors; Humans; In Vitro Techniques; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Respiratory Burst; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Tosylarginine Methyl Ester; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Tyrosine; Zymosan | 1992 |
Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.
Topics: Antigens, CD; Cell Line; Histocompatibility Antigens; Humans; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Common Antigens; Lymphocyte Activation; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase.
Topics: Animals; B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; Kinetics; Mice; Phosphorylation; Protein Kinases; Protein Tyrosine Phosphatases; Receptors, Fc; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glycogen Synthase Kinase 3; Insulin; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphorylation; Precipitin Tests; Protein Kinases; Swine; Tetradecanoylphorbol Acetate; Threonine; Trypsin; Tyrosine | 1991 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation.
Topics: Animals; Blotting, Western; Calcium; Cell Differentiation; Cytoskeleton; Cytosol; Genistein; Isoflavones; Keratinocytes; Mice; Mice, Inbred Strains; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Transglutaminases; Tyrosine | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; B-Lymphocytes; Calcium; Cell Division; Cross-Linking Reagents; Dose-Response Relationship, Immunologic; Histocompatibility Antigens; HLA-D Antigens; Humans; Immunoglobulin mu-Chains; Inositol Phosphates; Interleukin-4; Leukocyte Common Antigens; Lymphocyte Activation; Palatine Tonsil; Phosphatidylinositols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor Aggregation; Receptors, Antigen, B-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Tyrosine-specific protein phosphorylation during activation of human neutrophils.
Topics: Blotting, Western; Calcimycin; Cytosol; Humans; In Vitro Techniques; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Calcimycin; Calcium; Calcium Chloride; Cell Line; Histamine Release; Immunoglobulin E; Kinetics; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.
Topics: Antigens, Differentiation; Cell Line; Clone Cells; Enzyme Activation; Humans; In Vitro Techniques; Interleukin-2; Interleukin-4; Killer Cells, Natural; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Weight; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation.
Topics: Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoenzymes; Kinetics; Phosphates; Phosphoserine; Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.
Topics: Aluminum; Aluminum Compounds; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Benzoquinones; Calcium; CD40 Antigens; Cell Line; Cross-Linking Reagents; Fluorides; Genistein; Humans; Immunoglobulin M; Isoflavones; Lactams, Macrocyclic; Models, Biological; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Receptors, Antigen, B-Cell; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1991 |
Tyrosine protein phosphorylation is required for protein kinase C-mediated proliferation in T cells.
Topics: Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Gene Expression; Humans; In Vitro Techniques; Interleukin-2; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; ErbB Receptors; Gene Expression; Genes, ras; Humans; Phosphotyrosine; Poly A; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1991 |
Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I.
Topics: Antibodies, Anti-Idiotypic; B-Lymphocytes; Humans; Immunoglobulin M; In Vitro Techniques; Lymphocyte Activation; Molecular Weight; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages.
Topics: Animals; Benzoquinones; Cell Line, Transformed; Escherichia coli; Female; Kinetics; Lactams, Macrocyclic; Lipid A; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Salmonella; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3).
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Cell Line; Complement C5a; Cross-Linking Reagents; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Calcium; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chemokine CCL2; Chemotactic Factors; Cyclic AMP; DNA; Gene Expression; Genes, ras; GTP-Binding Proteins; Mice; Phosphorylation; Phosphotransferases; Phosphotyrosine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; rap GTP-Binding Proteins; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Tyrosine | 1991 |
Protein kinase C plays a role in the induction of tyrosine phosphorylation of lymphoid microtubule-associated protein-2 kinase. Evidence for a CD3-associated cascade that includes pp56lck and that is defective in HPB-ALL.
Topics: Antigens, Differentiation, T-Lymphocyte; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, Antigen, T-Cell; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1991 |
Regulation of c-myc and ornithine decarboxylase expression by distinct protein kinase systems in IL-3-dependent myeloid cells.
Topics: Animals; Blotting, Northern; Cell Division; Cell Line; Down-Regulation; Gene Expression; Genes, myc; Hematopoietic Stem Cells; In Vitro Techniques; Interleukin-3; Mice; Ornithine Decarboxylase; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Epidermal growth factor and 12-tetradecanoyl phorbol 13-acetate induction of urokinase in A431 cells.
Topics: Chromogenic Compounds; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Epidermal Growth Factor; Humans; Oligopeptides; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1991 |
PLC gamma 1, a possible mediator of T cell receptor function.
Topics: Antigens, Differentiation, T-Lymphocyte; Blotting, Western; CD3 Complex; Colforsin; Enzyme Activation; Humans; Leukemia; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases; Tyrosine | 1991 |
Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent hematopoietic cell line.
Topics: Cell Line; DNA Replication; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thymidine; Tyrosine; Vanadates | 1991 |
Interleukin 2 stimulates serine phosphorylation of CD45 in CTLL-2.4 cells.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Cells, Cultured; Histocompatibility Antigens; Interleukin-2; Leukocyte Common Antigens; Mice; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; Serine; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1991 |
Measuring the balance between insulin synthesis and insulin release.
Topics: Animals; Epinephrine; Glucagon; Glucose; Histidine; Homeostasis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Proinsulin; Protein Biosynthesis; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.
Topics: Animals; Autoradiography; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Enzyme Activation; ErbB Receptors; Mitogens; Mutation; Phosphorylation; Plasmids; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1991 |
Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation.
Topics: Antibodies, Anti-Idiotypic; Enzyme Activation; Humans; Hydrolysis; Immunoglobulin M; Lymphoma, B-Cell; Phosphatidylinositols; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1991 |
Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.
Topics: Animals; Blotting, Western; Bombesin; Bradykinin; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Inositol Phosphates; Mice; Phosphorylation; Substrate Specificity; Tetradecanoylphorbol Acetate; Tyrosine; Vasopressins | 1991 |
Vasoconstrictor-induced protein-tyrosine phosphorylation in cultured vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Ionomycin; Muscle, Smooth, Vascular; Norepinephrine; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Tyrosine; Vasoconstrictor Agents | 1991 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.
Topics: Animals; Diglycerides; Gene Amplification; Gene Expression; Humans; Phorbol Esters; Phosphorylation; Precipitin Tests; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Serine; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Phorbol ester treatment stimulates tyrosine phosphorylation of a sea urchin egg cortex protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Ammonium Chloride; Animals; Carrier Proteins; Egg Proteins; Female; Hydrogen-Ion Concentration; Isoquinolines; Molecular Weight; Ovum; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Sea Urchins; Signal Transduction; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
CD-3-mediated activation of MAP-2 kinase can be modified by ligation of the CD4 receptor. Evidence for tyrosine phosphorylation during activation of this kinase.
Topics: Adult; Antigens, Differentiation, T-Lymphocyte; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; CD4 Antigens; Enzyme Activation; Humans; Phosphorylation; Protein Kinases; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
2',3'cyclic nucleotide-3'-phosphodiesterase in peripheral nerve myelin is phosphorylated by a phorbol ester-sensitive protein kinase.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Cell-Free System; Colforsin; Female; Myelin Proteins; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinases; Rats; Rats, Inbred Strains; Sciatic Nerve; Second Messenger Systems; Substrate Specificity; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Reduced tyrosine phosphorylation and nonresponsiveness to EGF-mediated cytotoxicity in EGF receptor-hyperproducing UCVA-1 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Peptide Mapping; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.
Topics: Calcimycin; Chemotactic Factors; Humans; Hydroquinones; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
The role of signal-transducing events in the proliferative response of cells to a mitogenic viral K-ras protein.
Topics: Animals; Calcium; Cell Division; Cell Line; Diglycerides; Interphase; Mitosis; Oncogene Protein p21(ras); Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
[The effect of phorbol esters and Ca2+ ions on the process of autophosphorylation of epidermal growth factor receptor in vivo].
Topics: Calcimycin; Calcium; ErbB Receptors; Humans; Phosphorylation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Association of protein tyrosine phosphorylation with B cell differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: B-Lymphocytes; Cell Differentiation; Coumaric Acids; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Insulin receptor tyrosine residues 1162 and 1163 control insulin stimulation of myristoyl-diacylglycerol generation and subsequent activation of glucose transport.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Cell Line; Deoxyglucose; Diglycerides; Insulin; Kinetics; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Protein Kinase C; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1990 |
Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.
Topics: Amino Acids; Antibodies; Cell Line; DNA Replication; Humans; Interleukin-2; Killer Cells, Natural; Kinetics; Phosphorylation; Phytohemagglutinins; Receptors, Interleukin-2; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thymidine; Tyrosine | 1990 |
Biochemical characterization of two Epstein-Barr virus early antigen-associated phosphopolypeptides.
Topics: Antibodies, Monoclonal; Antigens, Viral; Cell Line; Chromatin; DNA; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Molecular Weight; Phosphopeptides; Phosphoserine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine; Viral Proteins | 1985 |
Tyrosine phosphorylation of platelet protein induced by phorbol ester.
Topics: Animals; Blood Platelets; Enzyme Activation; Kinetics; Microscopy, Electron; Microscopy, Electron, Scanning; Molecular Weight; Phorbols; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes.
Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Immunologic Techniques; Immunosorbent Techniques; Lymphoma; Mice; Molecular Weight; Phorbols; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
12-O-tetradecanoylphorbol-13-acetate stimulates phosphorylation of the 58,000-Mr form of polyomavirus middle T antigen in vivo: implications for a possible role of protein kinase C in middle T function.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Cell Line; Cell Transformation, Viral; Diglycerides; Mice; Molecular Weight; Mutation; Oncogene Proteins, Viral; Phorbols; Phosphorylation; Polyomavirus; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
PDGF-induced receptor phosphorylation and phosphoinositide hydrolysis are unaffected by protein kinase C activation in mouse Swiss 3T3 and human skin fibroblasts.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Humans; Mice; Phosphatidylinositols; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Regulation of the phosphorylation state and function of the epidermal growth factor receptor by vitamin K-3.
Topics: Calcium; Cells, Cultured; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine; Vitamin K | 1986 |
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor.
Topics: Animals; Antigens; Isoelectric Point; Lymphocyte Activation; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.
Topics: Animals; Bombesin; Cells, Cultured; Gastrin-Releasing Peptide; Growth Substances; Kinetics; Mice; Mitogens; Molecular Weight; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
Characterization of an endogenous substrate of the insulin receptor in cultured cells.
Topics: Animals; Cell Line; Cloning, Molecular; Humans; Insulin; Liver Neoplasms, Experimental; Phosphorus Radioisotopes; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1987 |
Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.
Topics: Animals; Cell Line; Immunoassay; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.
Topics: Animals; Blood Platelets; Cell Line; Humans; Immunoblotting; In Vitro Techniques; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins pp60(c-src); Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1989 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Pertussis toxin activates protein kinase C and a tyrosine protein kinase in the human T cell line Jurkat.
Topics: Calcium; Cell Line; Diglycerides; Enzyme Activation; Humans; Immunoblotting; Molecular Weight; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Phytohemagglutinins; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
Interleukin 3 and phorbol ester stimulate tyrosine phosphorylation of overlapping substrate proteins.
Topics: Animals; Cell Line; Electrophoresis, Gel, Two-Dimensional; Interleukin-3; Kinetics; Mice; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Tyrosine phosphorylation in human neutrophil.
Topics: Cinnamates; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; In Vitro Techniques; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Sulfides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1989 |
EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.
Topics: Animals; Calcimycin; Cell Differentiation; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Interleukin-3; Mast Cells; Mice; Oncogene Proteins; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Studies of signal transduction in the respiratory burst-associated stimulation of fMet-Leu-Phe-induced tubulin tyrosinolation and phorbol 12-myristate 13-acetate-induced posttranslational incorporation of tyrosine into multiple proteins in activated neutr
Topics: Cell Line; Diglycerides; Humans; In Vitro Techniques; Kinetics; Leukemia, Promyelocytic, Acute; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Kinase C; Protein Processing, Post-Translational; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Tubulin; Tyrosine | 1989 |
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
Topics: Animals; Catechol Oxidase; Cell Division; Cricetinae; Cyclic AMP; Cyclic GMP; Dihydroxyphenylalanine; Inositol 1,4,5-Trisphosphate; Melanins; Melanocyte-Stimulating Hormones; Melanoma, Experimental; Monophenol Monooxygenase; Phenotype; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1989 |
Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line.
Topics: Amino Acids; Animals; Bone Marrow; Cell Division; Cell Line; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cells; Humans; Interleukin-3; Kinetics; Mice; Mice, Inbred C57BL; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Tyrosine phosphorylation of a Mr 63,000 protein induced by an endogenous mitogen in human colon carcinoma cells, but not in normal colonocytes.
Topics: Carcinoma; Colon; Colonic Neoplasms; Diglycerides; Glycerides; Humans; Membrane Proteins; Mitogens; Molecular Weight; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Tyrosine phosphorylation in signal transduction.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Gene Expression Regulation; Immunoblotting; Mice; Mice, Inbred Strains; Peptide Mapping; Phosphorylation; Phosphotransferases; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1988 |
Phorbol ester stimulates catecholamine synthesis in isolated bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Bucladesine; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Cyclic AMP; Diterpenes; Enzyme Activation; In Vitro Techniques; Phorbols; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Protein kinase C promotes the phosphorylation of immunoprecipitated middle T antigen from polyoma-transformed cells.
Topics: Animals; Antigens, Polyomavirus Transforming; Antigens, Viral, Tumor; Calcimycin; Cell Transformation, Viral; Densitometry; Mice; Molecular Weight; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphorylation; Polyomavirus; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Retroviridae Proteins; Tetradecanoylphorbol Acetate; Threonine; Tyrosine; Vanadates; Vanadium | 1986 |
Effects of protein kinase C activation after epidermal growth factor binding on epidermal growth factor receptor phosphorylation.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1986 |
Mitogen treatment of permeabilized human T lymphocytes stimulates rapid tyrosine and serine phosphorylation of a 42 kDa protein.
Topics: Antibodies, Monoclonal; Cell Membrane Permeability; Humans; Mitogens; Phosphoproteins; Phosphorylation; Phytohemagglutinins; Serine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1986 |
Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Endothelium; Insulin; Phosphorylation; Rats; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Trypsin; Tyrosine | 1987 |
Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Dihydroxyphenylalanine; In Vitro Techniques; Isoquinolines; Piperazines; Tetradecanoylphorbol Acetate; Tyrosine; Vasoactive Intestinal Peptide | 1987 |
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Chromatography, Affinity; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Phosphoserine; Phosphothreonine; Protein-Tyrosine Kinases; Rats; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1988 |
Mitogen-stimulated tyrosine phosphorylation of a 42-kD cellular protein: evidence for a protein kinase-C requirement.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mitogens; Molecular Weight; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1988 |
Chemotactic factor induced tyrosine phosphorylation of membrane associated proteins in rabbit peritoneal neutrophils.
Topics: Animals; Kinetics; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1988 |
Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.
Topics: Animals; Cell Line; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Interphase; Kinetics; Mice; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Phorbol ester induces tyrosine phosphorylation in normal and abnormal human B lymphocytes.
Topics: B-Lymphocytes; Cell Differentiation; Humans; Leukemia, Lymphoid; Lymphocyte Activation; Molecular Weight; Phorbols; Phosphorylation; Polyethylene Glycols; Solubility; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Role of protein kinase C in the synthesis of catecholamine by isolated bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Carbachol; Catecholamines; Cattle; Colforsin; In Vitro Techniques; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Tumor promoters alter gene expression and protein phosphorylation in avian cells in culture.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Genes; Molecular Weight; Peptide Biosynthesis; Phorbols; Phosphorylation; Phosphotyrosine; Protein Biosynthesis; Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1981 |
Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes.
Topics: Cells, Cultured; Humans; Monocytes; Phorbol Esters; Phorbols; Phosphorylation; Phosphotyrosine; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.
Topics: Adenosine Triphosphate; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Weight; Peptide Fragments; Phorbols; Phosphorus Radioisotopes; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
A tumor promoter stimulates phosphorylation on tyrosine.
Topics: Animals; Chick Embryo; Fibroblasts; Molecular Weight; Phorbols; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1983 |
Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, fos; Genistein; Isoflavones; Lactams, Macrocyclic; Male; Muscle Proteins; Muscle, Smooth, Vascular; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Inbred BN; Receptors, Angiotensin; Rifabutin; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transcriptional Activation; Type C Phospholipases; Tyrosine | 1995 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Tyrosine kinase-dependent assembly of actin plaques linking Fc epsilon R1 cross-linking to increased cell substrate adhesion in RBL-2H3 tumor mast cells.
Topics: Actins; Animals; Antigens; Cell Adhesion; Mast Cells; Phosphotyrosine; Protein Binding; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1994 |
A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site.
Topics: alpha-Macroglobulins; Animals; Antibodies; Base Sequence; Binding Sites; Blotting, Western; Cell Differentiation; Cell Line; Cell Nucleus; DNA; Genes, fos; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-6; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphotyrosine; Promoter Regions, Genetic; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Tryptophan-tRNA Ligase; Tyrosine | 1994 |
Tyrosine phosphorylation of protein kinase C-delta in response to its activation.
Topics: 3T3 Cells; Adenosine Triphosphate; Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Genes, src; Interleukin-3; Isoenzymes; Mice; Molecular Sequence Data; Molecular Weight; Phosphopeptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase.
Topics: 3-O-Methylglucose; Animals; Cell Line; Fibroblasts; Glucose; Humans; Insulin; Isoenzymes; Kinetics; Mannitol; Methylglucosides; Phosphates; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
MAP kinase may play a role in the early phase of glucose transport in insulin treated 3T3-L1 fibroblasts.
Topics: 3T3 Cells; Animals; Biological Transport, Active; Calcium-Calmodulin-Dependent Protein Kinases; Fibroblasts; Glucose; Glucose Transporter Type 1; Insulin; Mice; Monosaccharide Transport Proteins; Phorbol Esters; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Basic fibroblast growth factor-induced low density lipoprotein receptor transcription and surface expression. Signal transduction pathways mediated by the bFGF receptor tyrosine kinase.
Topics: Animals; Cells, Cultured; Cholesterol; Fibroblast Growth Factor 2; Gene Expression Regulation; Muscle, Smooth, Vascular; Phosphoproteins; Phosphotyrosine; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, LDL; RNA, Messenger; Signal Transduction; Sterol O-Acyltransferase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1994 |
A tyrosine phosphorylation requirement for cytotoxic T lymphocyte degranulation.
Topics: Animals; Arsenicals; Calcium; Clone Cells; Concanavalin A; Fatty Acids, Nonesterified; Genistein; Ionomycin; Isoflavones; Kinetics; Lymphocyte Activation; Mice; Molecular Weight; Oleic Acid; Oleic Acids; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Comparison of retinoic acid and phorbol myristate acetate as inducers of monocytic differentiation.
Topics: CD18 Antigens; Cell Differentiation; Evaluation Studies as Topic; Gene Expression; Genes, myc; Humans; Integrins; Leukemia, Myeloid; Models, Biological; Monocytes; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myb; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin; Tyrosine | 1994 |
Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1.
Topics: Animals; Blotting, Western; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.
Topics: Antigen-Antibody Complex; CD28 Antigens; Detergents; Humans; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macromolecular Substances; Phosphoproteins; Phosphotyrosine; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Insulin stimulates phosphorylation of c-Jun, c-Fos, and Fos-related proteins in cultured adipocytes.
Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Electrophoresis, Polyacrylamide Gel; Gene Expression; Insulin; Kinetics; Mice; Phosphates; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1994 |
Insulin-stimulated tyrosine phosphorylation of protein kinase C alpha: evidence for direct interaction of the insulin receptor and protein kinase C in cells.
Topics: Animals; CHO Cells; Cricetinae; Insulin; Macromolecular Substances; Phosphotyrosine; Protein Binding; Protein Kinase C; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Calcium mobilisation controls tyrosine protein phosphorylation independently of the activation of protein kinase C in human platelets.
Topics: Blood Platelets; Calcium; Edetic Acid; Enzyme Activation; Humans; Indoles; Maleimides; Phosphorylation; Phosphotyrosine; Platelet Activation; Platelet Aggregation; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tyrosine | 1994 |
CD45-mediated regulation of extracellular calcium influx in a CD4-transfected human T cell line.
Topics: Calcium; CD4 Antigens; CD4-Positive T-Lymphocytes; Egtazic Acid; Humans; In Vitro Techniques; Inositol Phosphates; Leukocyte Common Antigens; Phosphoproteins; Phosphotyrosine; Receptor Aggregation; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tyrosine | 1994 |
Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells.
Topics: Amino Acid Sequence; Calcium; Cyclic AMP; Humans; In Vitro Techniques; Molecular Sequence Data; Osteoblasts; Peptides; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Receptors, Thrombin; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Cells, Cultured; Tyrosine | 1994 |
The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.
Topics: Cell Line; Enzyme Activation; Humans; In Vitro Techniques; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.
Topics: 3T3 Cells; Actins; Animals; Bombesin; Calcium; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Genistein; GTP Phosphohydrolases; GTP-Binding Proteins; Isoflavones; Lysophospholipids; Mice; Models, Biological; Myosins; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta.
Topics: Amino Acid Sequence; Animals; Bryostatins; Enzyme Activation; Isoenzymes; Lactones; Macrolides; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Spleen; Substrate Specificity; Swine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Regulation of endothelin-1- and lysophosphatidic acid-stimulated tyrosine phosphorylation of focal adhesion kinase (pp125fak) in Rat-1 fibroblasts.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium; Cell Adhesion Molecules; Cell Line; Egtazic Acid; Endothelins; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Homeostasis; Immunosorbent Techniques; Kinetics; Lysophospholipids; Molecular Sequence Data; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1994 |
Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.
Topics: Amino Acid Sequence; Antibodies; CD18 Antigens; Cell Adhesion; Enzyme Activation; Epitopes; Humans; Integrins; Kinetics; Molecular Sequence Data; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptides; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Activation of Ras and formation of GAP complex during TPA-induced monocytic differentiation of HL-60 cells.
Topics: Benzoquinones; Cell Differentiation; Dexamethasone; Enzyme Activation; Granulocytes; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Lactams, Macrocyclic; Monocytes; Mutation; Oncogene Protein p21(ras); Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinones; ras GTPase-Activating Proteins; Rifabutin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured; Tyrosine | 1994 |
Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma 2.
Topics: Cell Line; Humans; In Vitro Techniques; Interferon-gamma; Macromolecular Substances; Phosphotyrosine; Receptor Aggregation; Receptor Protein-Tyrosine Kinases; Receptors, Fc; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Up-Regulation | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Phorbol 12-myristate 13-acetic acid inhibits PTP1B activity in human mesangial cells. A possible mechanism of enhanced tyrosine phosphorylation.
Topics: Glomerular Mesangium; Humans; Immunosorbent Techniques; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin.
Topics: Alkaloids; Amino Acid Sequence; Antigens, CD; Antigens, CD7; Antigens, Differentiation, T-Lymphocyte; Calcium; Cell Adhesion; Cytochalasin B; Enzyme Activation; Fibronectins; Genistein; Humans; In Vitro Techniques; Integrins; Isoflavones; Killer Cells, Natural; Molecular Sequence Data; Peptides; Phosphoproteins; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Fibronectin; Receptors, IgG; Receptors, Immunologic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.
Topics: Benzoquinones; Cell Line; Gene Expression; Gene Rearrangement, T-Lymphocyte; Humans; In Vitro Techniques; Lactams, Macrocyclic; NF-kappa B; Oxidation-Reduction; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
Topics: Animals; DNA Mutational Analysis; Down-Regulation; Endopeptidases; Hematopoietic Cell Growth Factors; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Weight; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Stem Cell Factor; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Ubiquitins | 1994 |
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.
Topics: Animals; Caseins; Cell Aggregation; Cells, Cultured; Extracellular Matrix; Female; Gene Expression Regulation, Developmental; Genistein; In Vitro Techniques; Integrins; Isoflavones; Mice; Phosphotyrosine; Prolactin; Receptor Aggregation; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1994 |
Protein kinase C and insulin receptor beta-subunit serine phosphorylation in cultured foetal rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Enzyme Activation; Glucose; Glycogen; Insulin; Liver; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Rats; Receptor, Insulin; Swine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Alterations in expression of p56lck during myeloid differentiation of LSTRA cells.
Topics: Antigens, Differentiation; Bucladesine; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Cycle; Cell Differentiation; Cholecalciferol; Enzyme Induction; Granulocytes; Hematopoietic Stem Cells; Histocompatibility Antigens Class II; Humans; Leukemia; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
The Ca2+ signaling capacity of the beta 2-integrin on HL60-granulocytic cells is abrogated following phosphorylation of its CD18-chain: relation to impaired protein tyrosine phosphorylation.
Topics: Calcium; CD18 Antigens; Cell Differentiation; Cell Line; Cytosol; Integrins; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Ethanol enhances growth factor activation of mitogen-activated protein kinases by a protein kinase C-dependent mechanism.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Drug Synergism; Enzyme Activation; Ethanol; Fibroblast Growth Factor 2; Isoenzymes; Kinetics; Molecular Sequence Data; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.
Topics: Animals; Apoptosis; Calcium; CDC2 Protein Kinase; Cell Nucleus; DNA Damage; Lamin Type B; Lamins; Methylprednisolone; Mice; Mice, Inbred BALB C; Nuclear Proteins; Nucleosomes; Phosphotyrosine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors; Tyrosine | 1995 |
Activation of YRP kinase by v-Src and protein kinase C-mediated signal transduction pathways.
Topics: Animals; Avian Sarcoma Viruses; Cell Line, Transformed; Chick Embryo; Chickens; Enzyme Activation; Fibroblasts; Gene Expression; Genes, ras; Genes, src; Oncogene Protein pp60(v-src); Oncogene Proteins v-raf; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Retroviridae Proteins, Oncogenic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Effects of chromium on basal and insulin-induced tyrosine phosphorylation in H4 hepatoma cells: comparison with phorbol-12-myristate-13-acetate and sodium orthovanadate.
Topics: Animals; Chromium; Insulin; Insulin Receptor Substrate Proteins; Liver Neoplasms, Experimental; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1995 |
The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane.
Topics: 3T3 Cells; Animals; Base Sequence; Cytoplasm; DNA Primers; Fluorescent Antibody Technique; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatases; Recombinant Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Gene Expression; Genes, fos; GTP-Binding Proteins; Insulin; Intracellular Signaling Peptides and Proteins; Phosphotyrosine; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Receptors, Thrombin; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta; Becaplermin; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cytoskeletal Proteins; Endothelins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-sis; Rats; Receptor, Insulin; Recombinant Proteins; Stress, Mechanical; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1995 |
Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Line; DNA Primers; Enzyme Activation; Humans; Hydrogen Peroxide; Leukemia, T-Cell; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Phosphotyrosine; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A.
Topics: Animals; Benzoquinones; Cell Line; Dithiothreitol; Interleukin-1; Lactams, Macrocyclic; Mercaptoethanol; Mice; NF-kappa B; Phosphotyrosine; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
The protein kinase C isoforms leading to MAP-kinase activation in CHO cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; CHO Cells; Chromatography; Chromatography, Gel; Chromatography, Ion Exchange; Cricetinae; Cytosol; Durapatite; Enzyme Activation; Immunoblotting; Isoenzymes; Kinetics; Molecular Sequence Data; Phorbol 12,13-Dibutyrate; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells.
Topics: Alkaloids; Animals; Biological Transport; Carbachol; Cell Membrane; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; ErbB Receptors; Genistein; Isoenzymes; Isoflavones; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Receptor, Insulin; Salivary Glands; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Herbimycin A inhibits phorbol ester-induced morphologic changes, adhesion, and megakaryocytic differentiation of the leukemia cell line, MEG-01.
Topics: Benzoquinones; Cell Adhesion; Cell Differentiation; Genes, fos; Genes, jun; Humans; Lactams, Macrocyclic; Leukemia, Megakaryoblastic, Acute; Megakaryocytes; Naphthalenes; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Calbindin expression in renal tubular epithelial cells. Altered sodium phosphate co-transport in association with cytoskeletal rearrangement.
Topics: Actins; Animals; Base Sequence; Biological Transport; Calbindins; Calcium; Cell Line; Colforsin; Cytoskeleton; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Intracellular Signaling Peptides and Proteins; Kidney; Kidney Tubules; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Opossums; Phosphates; Phosphotyrosine; Proteins; Rats; Recombinant Proteins; S100 Calcium Binding Protein G; Sodium; Tetradecanoylphorbol Acetate; Tubulin; Tyrosine | 1995 |
CD30 ligand signal transduction involves activation of a tyrosine kinase and of mitogen-activated protein kinase in a Hodgkin's lymphoma cell line.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; CD30 Ligand; Enzyme Activation; Hodgkin Disease; Humans; Ligands; Membrane Glycoproteins; Molecular Weight; Myelin Basic Protein; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Division; CHO Cells; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Calcimycin; Calcium; Cell Line; Cloning, Molecular; Cytosol; DNA Primers; Gene Expression; Immunoblotting; Intracellular Signaling Peptides and Proteins; Leukemia, Basophilic, Acute; Mice; Molecular Sequence Data; Organ Specificity; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Receptors, IgE; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1.
Topics: Animals; Base Sequence; Cell Division; DNA; Enzyme Activation; Interferon-gamma; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred BALB C; Mitogens; Molecular Sequence Data; Oligonucleotides, Antisense; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
The mitogen-activated protein kinase cascade in rat islets of Langerhans.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Ethers, Cyclic; Glucose; Islets of Langerhans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Okadaic Acid; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase by protein kinase C and protein kinase A in EAhy926 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Indoles; Isoenzymes; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
The tyrosine phosphorylation of a p72syk-like protein in activated murine resident peritoneal macrophages.
Topics: Animals; Bacterial Proteins; Endotoxins; Enzyme Inhibitors; Enzyme Precursors; Female; Immunoblotting; Interferon Type I; Interleukin-1; Intracellular Signaling Peptides and Proteins; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Phosphoproteins; Phosphorylation; Pregnancy Proteins; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Signal Transduction; Syk Kinase; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells.
Topics: Animals; Humans; Interleukin-12; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Mice, Inbred BALB C; Phosphorylation; Rabbits; src-Family Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition.
Topics: Animals; Antigens; Cell Line; Cell Membrane; Immunoglobulin E; Isoenzymes; Kinetics; Leukemia, Basophilic, Acute; Phosphorylation; Phosphotyrosine; Protein Kinase C; Rats; Receptors, IgE; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Insulin activates nuclear factor kappa B in mammalian cells through a Raf-1-mediated pathway.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antioxidants; Aspirin; Base Sequence; Binding Sites; CHO Cells; Cricetinae; Cycloheximide; Enzyme Inhibitors; Humans; Insulin; Insulin-Like Growth Factor I; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NF-kappa B; Oligonucleotide Probes; Phosphorylation; Point Mutation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Pyrrolidines; Receptor, Insulin; Recombinant Proteins; Signal Transduction; Sodium Salicylate; Tetradecanoylphorbol Acetate; Thiocarbamates; Transcription Factor RelB; Transcription Factors; Transfection; Tyrosine | 1995 |
Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures.
Topics: Animals; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Mitogen-Activated Protein Kinase 1; Pertussis Toxin; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1995 |
Tyrosine-phosphorylation of tubulin during monocytic differentiation of HL-60 cells.
Topics: Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; Monocytes; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins pp60(c-src); Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrosine | 1993 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Effect of indomethacin and aspirin on the TNF-alpha-induced priming and protein tyrosyl phosphorylation of human neutrophils.
Topics: Animals; Aspirin; Azides; Electrophoresis, Polyacrylamide Gel; Granulocyte Colony-Stimulating Factor; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sodium Azide; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells.
Topics: Cell Differentiation; Cells, Cultured; Ceramides; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Mitogen-Activated Protein Kinase 1; Myelin Basic Protein; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1993 |
Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C.
Topics: Catechols; Genistein; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Monocytes; Naphthalenes; Nitriles; Phosphoproteins; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine; Tyrphostins; Vanadium; Zymosan | 1993 |
Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases.
Topics: Animals; Cell Transformation, Viral; Chick Embryo; DNA Mutational Analysis; Gene Expression Regulation, Enzymologic; Oncogene Protein pp60(v-src); Oncogene Proteins, Viral; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; RNA, Messenger; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tyrosine; Urokinase-Type Plasminogen Activator | 1993 |
Glucose transporter recycling in rat adipose cells. Effects of potassium depletion.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport; Blotting, Western; Cell Membrane; In Vitro Techniques; Insulin; Intracellular Membranes; Kinetics; Male; Methylglucosides; Monosaccharide Transport Proteins; Phosphoproteins; Phosphorylation; Phosphotyrosine; Potassium; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 2; Receptor, Insulin; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Tyrosine-kinase activity in rabbit platelets stimulated with platelet-activating factor. The effect of inhibiting tyrosine kinase with genistein on platelet-signal-molecule elevation and functional responses.
Topics: Animals; Blood Platelets; Cells, Cultured; Genistein; Inositol 1,4,5-Trisphosphate; Ionomycin; Isoflavones; Phosphorylation; Phosphotyrosine; Platelet Activating Factor; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Type C Phospholipases; Tyrosine | 1993 |
Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; CHO Cells; Cricetinae; Enzyme Activation; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Integrins; Naphthalenes; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Receptors, Fibronectin; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate.
Topics: Animals; Drug Synergism; Enzyme Activation; Female; Hydrogen Peroxide; Mice; Mice, Inbred C57BL; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1993 |
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Division; Gene Expression; Genes, myc; Humans; Immunoblotting; Interleukin-7; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1993 |
Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor.
Topics: Alkaloids; Amyloid; Carbachol; Cell Line; Genistein; Humans; Isoflavones; Phosphorylation; Prion Proteins; Prions; Protein Kinase Inhibitors; Protein Precursors; Protein Tyrosine Phosphatases; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of mitogen-activated protein kinase by protein kinase C- and pertussis toxin-dependent pathways in the endothelial cell line EAhy 926.
Topics: Cell Adhesion Molecules; Cells, Cultured; Endothelium; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Kinetics; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sensitivity and Specificity; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1995 |
Stimulus-dependent alterations in macrophage microtubules: increased tubulin polymerization and detyrosination.
Topics: Animals; Biopolymers; Cells, Cultured; Kinetics; Macrophages; Mice; Microtubules; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
Topics: Binding Sites; Blood Platelets; Cell Line; Cytoskeleton; GTP-Binding Proteins; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Megakaryocytes; Pertussis Toxin; Phosphorylation; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Receptors, Thrombin; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1995 |
Patterns of tyrosine phosphorylation differ in vascular hypertrophy and hyperplasia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cells, Cultured; Hyperplasia; Hypertrophy; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Prostaglandin Endoperoxides, Synthetic; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Thromboxane A2; Type C Phospholipases; Tyrosine | 1994 |
Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.
Topics: Animals; Down-Regulation; GTPase-Activating Proteins; Insulin; Liver Neoplasms, Experimental; Phosphorylation; Protein Kinase C; Proteins; Rats; Receptor, Insulin; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Activation of mesangial cells by the phosphatase inhibitor vanadate. Potential implications for diabetic nephropathy.
Topics: Calcium; Diabetic Nephropathies; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Glomerular Mesangium; Humans; Inositol Phosphates; Mitogens; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Tyrosine Phosphatases; RNA, Messenger; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine; Vanadates | 1995 |
Concurrent strong tyrosine phosphorylation of a 42,000 MW ERK and a 100,000 MW protein is associated with IL-2 production in human Jurkat T cells.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; CD3 Complex; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-2; Lymphocyte Activation; Molecular Weight; Phosphorylation; Protein Kinases; Receptors, Immunologic; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Oncogenically activated or ligand-stimulated neu kinase stimulates neurite outgrowth in PC12 cells.
Topics: Animals; Bucladesine; Cells, Cultured; DNA, Complementary; Enzyme Activation; ErbB Receptors; Glycoproteins; Ligands; Nerve Growth Factors; Neuregulins; Neurites; PC12 Cells; Phosphorylation; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Retroviridae; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bradykinin; Calcium; Cell Adhesion Molecules; Chelating Agents; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Isoquinolines; Mice; Paxillin; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cholecystokinin; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glycogen Synthase Kinase 3; Mitogen-Activated Protein Kinase 1; Pancreas; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1994 |
Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation.
Topics: Acetylcholine; Calcium; Carbachol; Cell Line; Cells, Cultured; Enzyme Activation; Humans; Kidney; Phospholipase D; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide-3 kinase correlate with Ca(2+)-independent costimulatory activity.
Topics: Amino Acid Sequence; Calcium; CD28 Antigens; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling.
Topics: Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Genes, fos; GTP-Binding Proteins; Myocardium; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Deficiency of tyrosine phosphorylation in a Balb/c 3T3 cell variant hypersensitive to phorbol ester-induced cell transformation.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Macrophages, Peritoneal; Maleimides; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Zymosan | 1994 |
Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.
Topics: Alkaloids; Base Sequence; Cell Differentiation; Humans; Molecular Sequence Data; Neuroblastoma; Neuropeptide Y; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Melittin inhibits epidermal growth factor-induced protein tyrosine phosphorylation: comparison with phorbol myristate acetate and calcium ionophore A23187.
Topics: 3T3 Cells; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Dimethyl Sulfoxide; Epidermal Growth Factor; Melitten; Mice; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Terminal differentiation and senescence in the human melanocyte: repression of tyrosine-phosphorylation of the extracellular signal-regulated kinase 2 selectively defines the two phenotypes.
Topics: Adult; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Nucleus; Cells, Cultured; Cellular Senescence; Cholera Toxin; Cyclic AMP; Cytoplasm; Enzyme Activation; Humans; Infant, Newborn; Melanins; Melanocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Biological Transport; Bone Marrow; Bone Marrow Cells; Cell Membrane; Cells, Cultured; GRB2 Adaptor Protein; Hematopoietic Cell Growth Factors; Humans; Interleukin-2; Interleukin-3; Interleukin-4; Mast Cells; Membrane Proteins; Mice; Oncogene Protein p21(ras); Phosphorylation; Protein Kinase C; Proteins; Shc Signaling Adaptor Proteins; Son of Sevenless Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor.
Topics: Angiotensin II; Animals; Autoradiography; Cells, Cultured; Colforsin; Immunoblotting; Ionomycin; Male; Muscle, Smooth, Vascular; Phosphorylation; Precipitin Tests; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Anti-CD2-induced tyrosine phosphorylation of T cell polypeptides is independent of the PMA-induced modification of p56lck.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Arsenicals; CD2 Antigens; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mitosis; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Immunologic; Serine; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Phenylarsine oxide and phorbol myristate acetate inhibit the CD3-induced rise of cytosolic Ca2+ in Jurkat cells by refilling internal Ca2+ stores.
Topics: Arsenicals; Biological Transport; Calcium; CD3 Complex; Cell Line; Cytosol; Ethers, Cyclic; Humans; Ionomycin; Okadaic Acid; Phosphatidylserines; Phosphorylation; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tyrosine | 1994 |
C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.
Topics: Benzoquinones; Cell Line; Chemotactic Factors; Complement C5a; Humans; In Vitro Techniques; Interleukin-8; Lactams, Macrocyclic; Leukotriene B4; Models, Biological; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Quinones; Receptor, Anaphylatoxin C5a; Receptors, Complement; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Immunosuppression induced by Salmonella involves inhibition of tyrosine phosphorylation in murine T lymphocytes.
Topics: Animals; Calcimycin; Immune Tolerance; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase C; Salmonella Infections, Animal; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.
Topics: Base Sequence; Cell Hypoxia; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Gene Expression Regulation; Humans; I-kappa B Proteins; Kinetics; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Oncogene Protein p65(gag-jun); Phosphorylation; Protein-Tyrosine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Translocation, Genetic; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Correlations among tyrosine phosphorylation of Shc, p72syk, PLC-gamma 1, and [Ca2+]i flux in Fc gamma RIIA signaling.
Topics: Amino Acid Sequence; Animals; Calcium; Cell Line; Enzyme Precursors; Inositol 1,4,5-Trisphosphate; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mice; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgG; Syk Kinase; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1994 |
Insulin receptor mutation at tyrosines 1162 and 1163 alters both receptor serine phosphorylation and desensitization.
Topics: Animals; CHO Cells; Cricetinae; Desensitization, Immunologic; Glycogen; Humans; Insulin; Mutation; Phosphorylation; Protein Kinase C; Receptor, Insulin; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1994 |
Activation of the respiratory burst and tyrosine phosphorylation of proteins in human neutrophils: no direct relationship and involvement of protein kinase C-dependent and -independent signaling pathways.
Topics: Concanavalin A; Genistein; Humans; Hydroquinones; Ionomycin; Isoflavones; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Protein Kinase C; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1993 |
Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes.
Topics: Animals; Calcium; Cell Differentiation; Cells, Cultured; Enzyme Activation; Isoenzymes; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphorylation; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1993 |
RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression Regulation; Genes, ras; Mutation; Phospholipases A; Phospholipases A2; Phosphorylation; Precipitin Tests; Rats; Tetradecanoylphorbol Acetate; Transfection; Tritium; Tyrosine | 1993 |
Neutrophil-catalysed dimerisation of tyrosyl peptides.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Kinetics; Macromolecular Substances; Molecular Sequence Data; Molecular Structure; Neutrophils; Peptides; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Activation; Humans; Male; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1994 |
Endothelins stimulate tyrosine phosphorylation and activity of p42/mitogen-activated protein kinase in astrocytes.
Topics: Aluminum; Aluminum Compounds; Animals; Astrocytes; Astrocytoma; Clone Cells; Endothelins; Enzyme Activation; Fluorides; Glycogen Synthase Kinase 3; Ligands; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Activation of cytosolic phospholipase A2 by transforming growth factor-alpha in HEL-30 keratinocytes.
Topics: Animals; Arachidonic Acids; Biological Transport; Calcium; Cell Line; Cytosol; Enzyme Activation; ErbB Receptors; Humans; Keratinocytes; Mice; Phospholipases A; Phospholipases A2; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tyrosine | 1993 |
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphorylation; Protein Kinase C; Protein Kinases; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1993 |
Early inhibition of protein phosphatases preferentially blocks phorbol ester-stimulated mitogenic signalling in melanocytes: increase in specific tyrosine phosphoproteins.
Topics: Animals; Blood; Cell Division; Cells, Cultured; DNA; Melanocytes; Mice; Mice, Inbred C57BL; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Inhibition of mitogen-induced proliferation of spleen lymphocytes is correlated with the induction of cell-mediated immunity in Salmonella infection in mice.
Topics: Animals; Concanavalin A; Hypersensitivity, Delayed; Immunity, Cellular; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Phytohemagglutinins; Protein Kinase C; Salmonella Infections, Animal; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.
Topics: Animals; B-Lymphocytes; Calcium; Mice; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Receptors, Antigen, B-Cell; Spleen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Cell adherence to fibronectin and the aggregation of the high affinity immunoglobulin E receptor synergistically regulate tyrosine phosphorylation of 105-115-kDa proteins.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Calcimycin; Fibronectins; Molecular Sequence Data; Molecular Weight; Phosphorylation; Precipitin Tests; Proteins; Rats; Receptor Aggregation; Receptors, IgE; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Okadaic acid activates p42 mitogen-activated protein kinase (MAP kinase; ERK-2) in B-lymphocytes but inhibits rather than augments cellular proliferation: contrast with phorbol 12-myristate 13-acetate.
Topics: B-Lymphocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Chromatography, Gel; Enzyme Activation; Ethers, Cyclic; Humans; Immunoglobulin M; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Okadaic Acid; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus, Type 1; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Phosphorylation; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland; Tyrosine | 1993 |
Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.
Topics: Animals; Calcimycin; Cell Adhesion; Cell Adhesion Molecules; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Immunoblotting; Kinetics; Phosphorylation; Protein-Tyrosine Kinases; Rats; Receptor Aggregation; Receptors, IgE; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Activation of MCP-1 gene expression is mediated through multiple signaling pathways.
Topics: Cells, Cultured; Chemokine CCL2; Chemotactic Factors; Cytokines; Endothelium, Vascular; Gene Expression; Humans; Lipopolysaccharides; Phosphorylation; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1993 |
Lateral mobility of Fc gamma RIIa is reduced by protein kinase C activation.
Topics: Animals; Antigen-Antibody Complex; Antigens, CD; Cell Membrane; CHO Cells; Cricetinae; Endocytosis; Enzyme Activation; Macrophages; Membrane Proteins; Mice; Mutagenesis; Protein Kinase C; Receptors, IgG; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Nitration of tyrosyl-residues from extra- and intracellular proteins in human whole blood.
Topics: Blood Proteins; Calcimycin; Humans; Ionophores; Kinetics; Neutrophils; Nitrates; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1995 |
Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells.
Topics: Cell Hypoxia; Cells, Cultured; Cobalt; Culture Media, Conditioned; Endothelial Growth Factors; Endothelium, Vascular; Fibroblasts; Humans; Lymphokines; Nickel; Phosphorylation; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine; Tritium; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1995 |
Protein kinase C regulates tyrosine phosphorylation of pp125FAK in platelets adherent to fibrinogen.
Topics: Adenosine Diphosphate; Apyrase; Blood Platelets; Calcium; Cell Adhesion Molecules; Cell Size; Egtazic Acid; Enzyme Inhibitors; Fibrinogen; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Maleimides; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tyrosine | 1996 |
1,25-dihydroxyvitamin D3 primes acute promyelocytic cells for TPA-induced monocytic differentiation through both PKC and tyrosine phosphorylation cascades.
Topics: Alkaloids; Calcitriol; Cell Differentiation; Enzyme Inhibitors; Genistein; Humans; Indoles; Isoflavones; Leukemia, Promyelocytic, Acute; Maleimides; Monocytes; Phagocytosis; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
Mycoplasma membrane lipoproteins induced proinflammatory cytokines by a mechanism distinct from that of lipopolysaccharide.
Topics: Cells, Cultured; Cytokines; Humans; Interleukin-1; Interleukin-6; Lipopolysaccharides; Lipoproteins; Mycoplasma; Phosphorylation; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1996 |
The Chinese herbal remedy, T2, inhibits mitogen-induced cytokine gene transcription by T cells, but not initial signal transduction.
Topics: Adult; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Calcineurin; Calmodulin-Binding Proteins; Cell Cycle; Cytokines; Diglycerides; Drugs, Chinese Herbal; Humans; Inositol 1,4,5-Trisphosphate; Interferon-gamma; Interleukin-2; Interleukin-6; Lymphocyte Activation; Mitogens; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Proteins; Receptors, Interleukin-2; Receptors, Transferrin; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tritium; Tyrosine; Uridine | 1996 |
Phorbol 12-myristate 13-acetate enhances nm23 gene expression in murine melanocytes but not in syngeneic B16-BL6 melanoma variants.
Topics: Animals; Cell Division; Cell Membrane; Cytosol; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Melanocytes; Melanoma, Experimental; Mice; Monomeric GTP-Binding Proteins; Neoplasm Metastasis; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Phenylalanine; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured; Tyrosine | 1996 |
Inhibition of PDGF-induced phospholipase C activation by herbimycin A.
Topics: 3T3 Cells; Animals; Benzoquinones; Enzyme Activation; Enzyme Inhibitors; Glycerophospholipids; Inositol Phosphates; Isoenzymes; Lactams, Macrocyclic; Mice; Phosphatidic Acids; Phospholipase C gamma; Phospholipase D; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1996 |
Activation of SRC family kinases in human neutrophils. Evidence that p58C-FGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity.
Topics: Actinin; Caveolin 1; Caveolins; Cell Fractionation; Cytoskeleton; Detergents; Enzyme Activation; Glucosides; Humans; Membrane Proteins; Neutrophil Activation; Neutrophils; Octoxynol; Phosphorylation; Proto-Oncogene Proteins; Solubility; src-Family Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Extracellular ATP activates mast cells via a mechanism that is different from the activation induced by the cross-linking of Fc receptors.
Topics: Adenosine Triphosphate; Animals; beta-N-Acetylhexosaminidases; Calcium; Cell Line; Cross-Linking Reagents; Extracellular Space; Genistein; Histamine Release; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Isoflavones; Mast Cells; Mice; Mice, Inbred A; Mice, Inbred C57BL; Naphthalenes; Phosphorylation; Protein Kinase C; Receptors, Fc; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1996 |
Biphasic activation of Fyn kinase upon fertilization of the sea urchin egg.
Topics: Amino Acid Sequence; Animals; Egg Proteins; Enzyme Activation; Fertilization; Molecular Sequence Data; Ovum; Parthenogenesis; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Sea Urchins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Physical and functional association of cortactin with Syk in human leukemic cell line K562.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cortactin; Enzyme Activation; Enzyme Precursors; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Microfilament Proteins; Phosphorylation; Protein-Tyrosine Kinases; Syk Kinase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1996 |
Differential effects of the protein kinase C activator phorbol 12-myristate 13-acetate on calcium responses and secretion in adherent and suspended RBL-2H3 mucosal mast cells.
Topics: Animals; Antigens; Biological Transport; Calcium; Cell Adhesion; Enzyme Activation; Isoenzymes; Mast Cells; Phosphorylation; Protein Kinase C; Rats; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured; Tyrosine | 1996 |
Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization.
Topics: 3T3 Cells; Animals; Biological Transport; Bombesin; CHO Cells; Cricetinae; Dexamethasone; Growth Hormone; Mice; Phosphorylation; Protein Binding; Rats; Receptors, Bombesin; Receptors, Somatotropin; Recombinant Proteins; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by genistein, a tyrosine kinase inhibitor.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Enzyme Inhibitors; Genistein; Haplorhini; Isoflavones; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Insulin potentiates mitogenic effect of epidermal growth factor on cultured guinea pig gastric mucous cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; Gastric Mucosa; Guinea Pigs; Insulin; Intracellular Membranes; Male; Mitogens; Osmolar Concentration; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha.
Topics: Alkaloids; Base Sequence; Calcimycin; Cell Hypoxia; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Genistein; Humans; I-kappa B Proteins; Ionophores; Isoflavones; Leukocyte Common Antigens; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Binding; Protein Kinase C; Protein Tyrosine Phosphatases; src-Family Kinases; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Vanadates | 1996 |
A purified protein from Salmonella typhimurium inhibits proliferation of murine splenic anti-CD3 antibody-activated T-lymphocytes.
Topics: Animals; Bacterial Proteins; CD3 Complex; Cells, Cultured; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Receptors, Interleukin-2; Salmonella typhimurium; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fc gamma receptor activation: study of the signaling mechanism.
Topics: Animals; Antigen-Antibody Complex; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Base Sequence; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Intercellular Signaling Peptides and Proteins; Macrophages, Peritoneal; Male; Molecular Sequence Data; Phosphorylation; Rats; Rats, Wistar; Receptors, IgG; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site.
Topics: 3T3 Cells; Animals; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Isoenzymes; Mice; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-delta; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1996 |
Gene expression and cellular sources of inducible nitric oxide synthase during tumor promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinogens; DNA Primers; Enzyme Induction; Female; Keratinocytes; Mice; Mice, Inbred Strains; Models, Biological; Nitric Oxide Synthase; Polymerase Chain Reaction; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1996 |
Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase C.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Down-Regulation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Naphthalenes; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1996 |
Rapid activation of mitogen-activated protein kinase and p21ras by prolactin and interleukin 2 in rat Nb2 node lymphoma cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Genistein; Guanosine Triphosphate; Interleukin-2; Isoflavones; Lymph Nodes; Lymphoma, T-Cell; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1995 |
Tyrosine phosphorylation and subcellular redistribution of p125 ras guanosine triphosphatase-activating protein in human neutrophils stimulated with FMLP.
Topics: Cell Membrane; Concanavalin A; Cytosol; GTPase-Activating Proteins; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Phosphotyrosine; Proteins; ras GTPase-Activating Proteins; Respiratory Burst; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Regulation of natural killer cell-mediated cytotoxicity by serine/threonine phosphatases: identification of a calyculin A-sensitive serine/threonine kinase.
Topics: CD28 Antigens; Cell Line; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Enzyme Stability; Ionophores; Killer Cells, Natural; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Myeloperoxidase-dependent generation of a tyrosine peroxide by neutrophils.
Topics: Chromatography, High Pressure Liquid; Humans; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Neutrophils; Oxidation-Reduction; Peroxidase; Peroxides; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; Binding Sites; Carcinogens; COS Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Jurkat Cells; Mice; Molecular Sequence Data; Oncogene Protein v-cbl; Peptide Mapping; Phorbol Esters; Phosphorylation; Protein Conformation; Protein-Tyrosine Kinases; Proteins; Rabbits; Receptor-CD3 Complex, Antigen, T-Cell; Retroviridae Proteins, Oncogenic; Serine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Tyrosine 3-Monooxygenase | 1997 |
Release of gelatinase A during platelet activation mediates aggregation.
Topics: Amides; Apyrase; Aspirin; Blotting, Western; Collagen; Epoprostenol; Gelatinases; Humans; In Vitro Techniques; Matrix Metalloproteinase 2; Metalloendopeptidases; Nitric Oxide; Phenanthrolines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protease Inhibitors; Proteins; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thrombin; Tissue Inhibitor of Metalloproteinase-2; Tyrosine | 1997 |
Activation-induced expression of human programmed death-1 gene in T-lymphocytes.
Topics: Antigens, CD; Antigens, Surface; Apoptosis Regulatory Proteins; Cell Differentiation; Humans; Jurkat Cells; Lymphocyte Activation; Phosphorylation; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Up-Regulation | 1997 |
The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptor.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calcium; Carcinogens; Down-Regulation; Enzyme Precursors; Intracellular Signaling Peptides and Proteins; Ionophores; Molecular Sequence Data; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Conformation; Protein-Tyrosine Kinases; Rats; Receptors, IgE; src Homology Domains; Syk Kinase; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Shrinkage-induced protein tyrosine phosphorylation in Chinese hamster ovary cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; GRB2 Adaptor Protein; Mitogen-Activated Protein Kinase 1; Osmotic Pressure; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Signal Transduction; src Homology Domains; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Protein kinase C inhibits epidermal growth factor receptor phosphorylation in enterocytes.
Topics: Animals; Cell Communication; Cell Line; ErbB Receptors; Intestinal Mucosa; Intestines; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1997 |
Nitric oxide inhibits neutrophil beta 2 integrin function by inhibiting membrane-associated cyclic GMP synthesis.
Topics: Animals; Atrial Natriuretic Factor; CD18 Antigens; Cell Adhesion; Cell Degranulation; Cyclic GMP; Glutathione; Guanylate Cyclase; Hydrazines; Male; Neutrophils; Nitric Oxide; Nitrogen Oxides; Protein Kinase C; Rats; Rats, Wistar; Respiratory Burst; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Ca2+ and protein kinase C-dependent mechanisms involved in gastrin-induced Shc/Grb2 complex formation and P44-mitogen-activated protein kinase activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Gastrins; GRB2 Adaptor Protein; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms, Experimental; Phosphorylation; Protein Kinase C; Proteins; Rats; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured; Tyrosine | 1997 |
Differential regulation of extracellular signal-regulated kinase 1 and 2 activity during 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of HL-60 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Peptides; Phosphorylation; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1997 |
Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation.
Topics: Actins; Animals; Bacterial Toxins; Cell Adhesion; Cell Adhesion Molecules; CHO Cells; Cricetinae; Cytoskeleton; Cytotoxins; Enzyme Activation; Escherichia coli Proteins; Fibrinogen; Fluorescent Antibody Technique, Indirect; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; GTPase-Activating Proteins; Integrins; Mice; Phosphorylation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Receptor, Insulin; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1997 |
Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho.
Topics: Actins; Animals; Calcimycin; Calcium; Cell Adhesion Molecules; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Indoles; Inositol Phosphates; Kinetics; Male; Maleimides; Models, Biological; Pancreas; Paxillin; Phospholipases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; rho GTP-Binding Proteins; Sincalide; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Activation of gene expression by a non-transforming unmyristylated-SH3-deleted mutant of Src is dependent upon Tyr-527.
Topics: 3T3 Cells; Animals; Chickens; CSK Tyrosine-Protein Kinase; DNA-Binding Proteins; Gene Expression Regulation; Genes, Immediate-Early; Mice; Mutagenesis, Insertional; Myristic Acids; Nuclear Proteins; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Sequence Deletion; Serum Response Factor; src Homology Domains; src-Family Kinases; Tetradecanoylphorbol Acetate; Transformation, Genetic; Tyrosine | 1997 |
CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.
Topics: Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-fos; Staurosporine; Substance P; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1997 |
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. I. Activation of protein kinase C stimulates tyrosine phosphorylation and activation of ErbB2 and ErbB3.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Enzyme Activation; ErbB Receptors; GRB2 Adaptor Protein; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptor, ErbB-3; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; src Homology Domains; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1997 |
Cross-talk between phorbol ester-mediated signaling and tyrosine kinase proto-oncogenes. II. Comparison of phorbol ester and sphingomyelinase-induced phosphorylation of ErbB2 and ErbB3.
Topics: 3T3 Cells; Animals; Carrier Proteins; Enzyme Activation; ErbB Receptors; Glycoproteins; Mice; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Receptor, ErbB-3; Signal Transduction; Sphingomyelin Phosphodiesterase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1997 |
Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Enzyme Activation; Humans; Insulin Receptor Substrate Proteins; Kidney; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1997 |
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Culture Techniques; Cell Death; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Lymphokines; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Lipoarabinomannan of Mycobacterium tuberculosis promotes protein tyrosine dephosphorylation and inhibition of mitogen-activated protein kinase in human mononuclear phagocytes. Role of the Src homology 2 containing tyrosine phosphatase 1.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Humans; Interferon-gamma; Interleukin-12; Lipopolysaccharides; Membrane Proteins; Monocytes; Mycobacterium tuberculosis; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; RNA, Messenger; src Homology Domains; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 1998 |
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
Topics: Adenosine Triphosphate; Animals; Enzyme Activation; Focal Adhesion Kinase 2; Isoenzymes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; PC12 Cells; Pertussis Toxin; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Receptors, Purinergic P2; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Uridine Triphosphate; Virulence Factors, Bordetella | 1998 |
Stimulation of 42/44 kDa mitogen-activated protein kinases by arginine vasopressin in rat cardiomyocytes.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myelin Basic Protein; Myocardium; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Vasopressin; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Tyrosine; Vasoconstrictor Agents | 1998 |
The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway.
Topics: Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Carcinoma, Squamous Cell; Enzyme Activation; Enzyme Induction; Genistein; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Phosphotyrosine; Protein Kinase C; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1998 |
Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity.
Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Intestinal Mucosa; Mice; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1998 |
Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Genistein; Pertussis Toxin; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin; Thyroid Gland; Tyrosine; Vanadates; Virulence Factors, Bordetella | 1998 |
Progesterone-stimulated intracellular calcium increase in human spermatozoa is protein kinase C-independent.
Topics: Calcium; Cell Membrane; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Humans; Male; Peanut Agglutinin; Phosphorylation; Progesterone; Protein Kinase C; Proteins; Sperm Capacitation; Spermatozoa; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Association of PKC delta and active Src in PMA-treated MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Extracts; Cell Fractionation; Enzyme Activation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Isoenzymes; Mitogens; Molecular Chaperones; Neoplasm Proteins; Oncogene Protein pp60(v-src); Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tyrosine | 1998 |
1alpha,25(OH)2-vitamin D3 signaling in chick enterocytes: enhancement of tyrosine phosphorylation and rapid stimulation of mitogen-activated protein (MAP) kinase.
Topics: Animals; Calcitriol; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chickens; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genistein; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Corpus Luteum; Dinoprost; Female; Immunoblotting; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Osmolar Concentration; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1998 |
Are tyrosine phosphorylation of p125(FAK) and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion?
Topics: ADP Ribose Transferases; Amylases; Animals; Botulinum Toxins; Cell Adhesion Molecules; Cells, Cultured; Cytochalasin D; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; GTP-Binding Proteins; Male; Pancreas; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Signal Transduction; Sincalide; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Early phosphorylation events induced by DPIV/CD26-specific inhibitors.
Topics: Calcium; CD3 Complex; Cyclic AMP; Dipeptidyl Peptidase 4; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lysine; Mitogens; Phosphorylation; Piperidines; Protease Inhibitors; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thiazoles; Tyrosine | 1998 |
Matrilysin expression and function in airway epithelium.
Topics: Amides; Animals; Cell Movement; Cystic Fibrosis; Enzyme Induction; Epithelial Cells; Female; Gene Expression Regulation, Enzymologic; Humans; Lung; Lung Diseases; Lung Neoplasms; Matrix Metalloproteinase 7; Metalloendopeptidases; Mice; Mice, Knockout; Protease Inhibitors; Pulmonary Alveoli; Tetradecanoylphorbol Acetate; Trachea; Tumor Cells, Cultured; Tyrosine | 1998 |
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Peroxynitrite is not a major mediator of endothelial cell injury by activated neutrophils in vitro.
Topics: Animals; Antibodies, Monoclonal; Cattle; CD18 Antigens; Cells, Cultured; Coculture Techniques; Deferoxamine; Dimethyl Sulfoxide; Endothelium, Vascular; Humans; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Ornithine; Penicillamine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Protein kinase C delta (PKCdelta) inhibits the expression of glutamine synthetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation.
Topics: Bryostatins; Catalytic Domain; Cells, Cultured; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Humans; Isoenzymes; Lactones; Macrolides; Mutagenesis, Site-Directed; Neuroglia; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli.
Topics: Animals; Carbachol; Carcinogens; Enzyme Inhibitors; Epithelial Cells; Genistein; Isoenzymes; Muscarinic Agonists; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Rats; Staurosporine; Substance P; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Expression of Src family kinases and their putative substrates in the human preosteoclastic cell line FLG 29.1.
Topics: Blotting, Western; Catenins; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cell Line; Crk-Associated Substrate Protein; CSK Tyrosine-Protein Kinase; Delta Catenin; Electrophoresis, Polyacrylamide Gel; Filaggrin Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Osteoclasts; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Stem Cells; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Vinculin | 1998 |
Priming of human neutrophils by peroxynitrite: potential role in enhancement of the local inflammatory response.
Topics: Antioxidants; Blood Proteins; Calcium; Cells, Cultured; Humans; Inflammation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrates; Oxidants; Pyrimidines; Pyrrolidines; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
IL-3 and IL-4 activate cyclic nucleotide phosphodiesterases 3 (PDE3) and 4 (PDE4) by different mechanisms in FDCP2 myeloid cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Insulin Receptor Substrate Proteins; Interleukin-3; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction; STAT6 Transcription Factor; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Topics: Animals; Cell Membrane; COS Cells; Epidermal Growth Factor; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Functional muscarinic m3 receptor expressed in gastric cancer cells stimulates tyrosine phosphorylation and MAP kinase.
Topics: Atropine; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Densitometry; Dose-Response Relationship, Drug; Humans; Intracellular Fluid; Naphthalenes; Phosphorylation; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine | 1999 |
Phosphorylation of p67phox in the neutrophil occurs in the cytosol and is independent of p47phox.
Topics: Binding Sites; Cells, Cultured; Cytosol; Humans; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Tyrosine; Zymosan | 1999 |
Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB cascades, but not lipopolysaccharide-incorporatio
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Drug Tolerance; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; NF-kappa B; Paclitaxel; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Protein kinase C-alpha produces reciprocal effects on the phorbol ester stimulated tyrosine phosphorylation of a 50 kDa kinase in Jurkat cells.
Topics: Adenosine; Affinity Labels; Cell Extracts; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Jurkat Cells; Kinetics; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Substrate Specificity; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Enzyme Activation; Humans; Jurkat Cells; Nuclear Proteins; Oncogene Protein v-cbl; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proteins; Retroviridae Proteins, Oncogenic; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; src Homology Domains; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1999 |
Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells.
Topics: Animals; Anti-Allergic Agents; Capillaries; Capillary Permeability; Cattle; Cell Division; Cell Hypoxia; Cells, Cultured; DNA; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Lymphokines; Neovascularization, Physiologic; ortho-Aminobenzoates; Phosphorylation; Protein Kinase C; Retinal Vessels; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages.
Topics: Animals; Antigen-Antibody Complex; Arteriosclerosis; Autoantibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; Lipoproteins, LDL; Macrophages; Phosphorylation; Rabbits; Receptors, IgG; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 1999 |
Role of protein kinase C in signal attenuation following T cell receptor engagement.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Humans; Jurkat Cells; Lymphocyte Activation; Mice; Oncogene Protein v-cbl; Protein Kinase C; Protein Kinases; Proteins; Proto-Oncogene Mas; Receptors, Antigen, T-Cell; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Intracellular Signaling Peptides and Proteins; Leishmania donovani; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Tetradecanoylphorbol Acetate; Transcription Factors; Tyrosine | 1999 |
Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Chemotactic Factors; Complement C5a; Cytokines; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Neutrophils; Phosphorylation; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Tyrosine | 1999 |
Molecular cloning and characterization of a novel member of the MAP kinase superfamily.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Calcium-Calmodulin-Dependent Protein Kinases; Chromosome Mapping; Chromosomes, Human, Pair 14; Cloning, Molecular; COS Cells; DNA, Complementary; Enzyme Activation; Expressed Sequence Tags; Female; Gene Expression; Glucose; Humans; Male; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Conformation; Receptor for Advanced Glycation End Products; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate; Threonine; Tissue Distribution; Tyrosine | 1999 |
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.
Topics: Androstadienes; Cell Adhesion; Cell Size; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesion Kinase 2; Humans; Integrins; Neutrophil Activation; Neutrophils; Nitriles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins; Wortmannin | 1999 |
Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Enzyme Inhibitors; Glucose; Insulin; Isoenzymes; Muscle, Skeletal; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Local anesthetics inhibit muscarinic receptor-mediated activation of extracellular signal-regulated kinases in rat pheochromocytoma PC12 cells.
Topics: Anesthetics, Local; Animals; Carbachol; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscarinic Agonists; Muscarinic Antagonists; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Procaine; Rats; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tetrodotoxin; Tyrosine | 1999 |
Activation of protein kinase C is required for the stable attachment of adherent platelets to collagen but is not needed for the initial rapid adhesion under flow conditions.
Topics: Animals; Antibodies; Blood Flow Velocity; Blood Platelets; Blood Proteins; Carbazoles; Carcinogens; Cell Adhesion Molecules; Collagen; Enzyme Inhibitors; Enzyme Precursors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Integrins; Intracellular Signaling Peptides and Proteins; Maleimides; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Protein Conformation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptors, Collagen; Skin; Stimulation, Chemical; Syk Kinase; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts.
Topics: Animals; Antigens, CD; CD24 Antigen; Cell Adhesion; Cell Membrane; Cholera Toxin; Female; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Tyrosine phosphorylation of alpha-actinin in activated platelets.
Topics: Actinin; Blood Platelets; Cell Adhesion Molecules; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet Activation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes.
Topics: ADP-Ribosylation Factors; Cinnamates; Drug Synergism; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Isoenzymes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipase D; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Sulfides; Tetradecanoylphorbol Acetate; Tyrosine; Vanadium Compounds | 1999 |
Platelet-derived growth factor and lysophosphatidic acid inhibit growth hormone binding and signaling via a protein kinase C-dependent pathway.
Topics: 3T3 Cells; Animals; Down-Regulation; Enzyme Activation; Growth Hormone; Humans; Janus Kinase 2; Lysophospholipids; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Protein kinase C is involved in enhanced airway smooth muscle cell growth in hyperresponsive rats.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Cattle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging.
Topics: Aging; Animals; Calcimycin; Enzyme Activation; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Lymphocyte Activation; Lymphocytes; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Phosphorylation; Proteins; Rats; Rats, Inbred F344; Signal Transduction; Spleen; Tetradecanoylphorbol Acetate; Transcription Factors; Tyrosine | 2000 |
Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck.
Topics: CD4 Antigens; Cross-Linking Reagents; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Genistein; Humans; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Phosphorylation; Protein Binding; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2000 |
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130.
Topics: Animals; Base Sequence; Cell Line; Cytoplasm; DNA-Binding Proteins; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Interleukin-6; Lysosomal Membrane Proteins; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Oligodeoxyribonucleotides; Proteins; Repressor Proteins; RNA, Messenger; STAT1 Transcription Factor; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Tyrosine | 2000 |
Effect of timosaponin E1 and E2 on superoxide generation induced by various stimuli in human neutrophils and on platelet aggregation in human blood.
Topics: Blood Proteins; Carbohydrate Sequence; Hemolysis; Humans; Neutrophils; Phosphorylation; Platelet Aggregation Inhibitors; Saponins; Steroids; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase.
Topics: Adenoviridae; Animals; Calcium Channel Blockers; Cardiomegaly; Cell Adhesion; Cells, Cultured; Cytoskeletal Proteins; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Heart; Myocardium; Myosin Heavy Chains; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2000 |
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Base Sequence; Biological Transport; Cell Line; Cell Transformation, Neoplastic; DNA; Fibroblasts; Humans; Isoenzymes; Mice; Mutagenesis, Site-Directed; Phenylalanine; Protein Kinase C; Protein Kinase C-delta; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Enhancement of Ca2+-induced noradrenaline release by vanadate in PC12 cells: possible involvement of tyrosine phosphorylation.
Topics: Animals; Calcium; Intercellular Signaling Peptides and Proteins; Intracellular Membranes; Ionomycin; Ionophores; Norepinephrine; Osmolar Concentration; PC12 Cells; Peptides; Phosphorylation; Rats; Tetradecanoylphorbol Acetate; Tetramisole; Tyrosine; Vanadates; Wasp Venoms | 2000 |
Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse.
Topics: Animals; Apolipoproteins B; Hydrogen Peroxide; Lipid Peroxidation; Lipoproteins, LDL; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Neutrophils; Nitrogen Compounds; Oxidation-Reduction; Peroxidase; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.
Topics: Animals; Cell Division; Cloning, Molecular; Enzyme Inhibitors; Genes, Dominant; Glutamate-Ammonia Ligase; Green Fluorescent Proteins; Immunoblotting; Isoenzymes; Luminescent Proteins; Mice; Microscopy, Confocal; Mutagenesis, Site-Directed; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyrazoles; Pyrimidines; Recombinant Fusion Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tyrosine | 2000 |
Chronic PMA treatment of Jurkat T lymphocytes results in decreased protein tyrosine phosphorylation and inhibition of CD3- but not Ti-dependent antibody-triggered Ca2+ signaling.
Topics: Calcium; Carcinogens; CD3 Complex; Humans; Jurkat Cells; Phosphorylation; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Thermodynamic mixing of molecular states of the epidermal growth factor receptor modulates macroscopic ligand binding affinity.
Topics: Animals; CHO Cells; Cricetinae; Cytosol; ErbB Receptors; Glutamic Acid; Humans; Kinetics; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Phorbol Esters; Phosphorylation; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Tetradecanoylphorbol Acetate; Thermodynamics; Tumor Cells, Cultured; Tyrosine | 2000 |
Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.
Topics: Androstadienes; Angiotensin II; Animals; Animals, Newborn; Astrocytes; Bradykinin; Bucladesine; Cerebral Cortex; Chelating Agents; Cytochalasin B; Cytoskeletal Proteins; Cytoskeleton; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-3; Endothelins; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Paxillin; Pertussis Toxin; Phosphoproteins; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Modulation of CD157 expression in multi-lineage myeloid differentiation of promyelocytic cell lines.
Topics: ADP-ribosyl Cyclase; Antigens, CD; Bucladesine; Calcitriol; Cell Differentiation; Cell Line; Cell Lineage; Cell Separation; Cells, Cultured; Colforsin; Detergents; Dose-Response Relationship, Drug; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; GPI-Linked Proteins; Granulocytes; HL-60 Cells; Humans; Immunoblotting; Kinetics; Macrophage-1 Antigen; Membrane Glycoproteins; Monocytes; Octoxynol; Phenotype; Phosphorylation; Polyethylene Glycols; Precipitin Tests; Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells; Up-Regulation | 2000 |
Serotonin transporter phosphorylation modulated by tetanus toxin.
Topics: Animals; Biological Transport; Brain; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Isotope Labeling; Maleimides; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Serine; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes; Tetanus Toxin; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases; Tyrosine | 2000 |
CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.
Topics: Blotting, Western; Cell Differentiation; Cell Line; Cytoplasm; Enzyme Activation; Flavonoids; Flow Cytometry; Genetic Vectors; Humans; Isoenzymes; Leukocyte Common Antigens; Macrophage-1 Antigen; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; U937 Cells | 2001 |
Regulation of tyrosinase expression and activity in cultured human retinal pigment epithelial cells.
Topics: Adjuvants, Immunologic; Aged; alpha-MSH; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Cholera Toxin; Cloning, Molecular; DNA, Complementary; Epithelial Cells; Eye Proteins; Fibroblast Growth Factor 2; Gene Expression Regulation, Enzymologic; Humans; Luciferases; Melanocytes; Methyl Methanesulfonate; Middle Aged; Monophenol Monooxygenase; Mutagens; Nerve Growth Factors; Pigment Epithelium of Eye; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteins; RNA Processing, Post-Transcriptional; Serpins; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tyrosine; Up-Regulation; Uvea; Verapamil | 2000 |
Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor.
Topics: Amino Acid Sequence; Animals; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Okadaic Acid; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 2001 |
PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes.
Topics: Crk-Associated Substrate Protein; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Isoenzymes; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Retinoblastoma-Like Protein p130; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells.
Topics: Aniline Compounds; Animals; Antioxidants; Blotting, Western; Cattle; Cell Death; Enzyme Inhibitors; Epithelial Cells; Female; Free Radical Scavengers; Histidine; L-Lactate Dehydrogenase; Lipopolysaccharides; Mammary Glands, Animal; Molsidomine; Neutrophil Activation; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidants; Peroxidase; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.
Topics: Adaptor Proteins, Signal Transducing; Calcimycin; CD28 Antigens; CD3 Complex; Cell Cycle Proteins; DNA-Binding Proteins; Enzyme Activation; Humans; I-kappa B Proteins; Ionophores; Isoenzymes; Jurkat Cells; Kinetics; Lymphocyte Activation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphoproteins; Protein Kinase C; Protein Kinase C-theta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; ZAP-70 Protein-Tyrosine Kinase | 2001 |
Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events.
Topics: Actins; alpha Catenin; Cadherins; Carcinogens; Cell Adhesion; Cell Line; Cytoskeletal Proteins; Enzyme Inhibitors; Focal Adhesions; Humans; Indoles; Integrin beta1; Intestinal Mucosa; Leukotriene D4; Maleimides; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Tetradecanoylphorbol Acetate; Tyrosine; Vinculin | 2001 |
Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases.
Topics: Animals; Calcium; Carbachol; Carcinogens; Cholinergic Agents; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Estrenes; Isoenzymes; Male; Neurons; Parotid Gland; PC12 Cells; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serine; src-Family Kinases; Substance P; Tetradecanoylphorbol Acetate; Threonine; Tyrosine; Vanadates | 2001 |
Effects of riluzole on N-methyl-D-aspartate-induced tyrosine phosphorylation in the rat hippocampus.
Topics: Animals; Carcinogens; Excitatory Amino Acid Agonists; Hippocampus; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Phosphorylation; Precipitin Tests; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Riluzole; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication.
Topics: B-Lymphocytes; Cell Line; Herpesvirus 8, Human; Humans; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine; Viral Proteins; Virus Replication | 2001 |
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Topics: Anticarcinogenic Agents; Carcinogens; Drug Interactions; Enzyme Activation; HeLa Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Estrogen; Resveratrol; src-Family Kinases; Stilbenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tyrosine; Ultraviolet Rays | 2001 |
Protein tyrosine nitration in cytokine-activated murine macrophages. Involvement of a peroxidase/nitrite pathway rather than peroxynitrite.
Topics: Animals; Cell Line; Cytokines; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Free Radical Scavengers; Hydrogen Peroxide; Immunoblotting; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitrates; Nitric Oxide; Nitrites; Nitrogen; Oxygen; Peroxidase; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Zymosan | 2001 |
Insulin- and glucose-induced phosphorylation of the Na(+),K(+)-adenosine triphosphatase alpha-subunits in rat skeletal muscle.
Topics: Animals; Cell Membrane; Enzyme Inhibitors; Extracellular Space; Glucose; Indoles; Insulin; Male; Maleimides; Muscle, Skeletal; Phosphoamino Acids; Phosphorylation; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Tissue Distribution; Tyrosine | 2001 |
Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene.
Topics: Base Sequence; Carcinogens; Cells, Cultured; DNA; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon gamma Receptor; Interferon-gamma; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Receptors, Interferon; Serine; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Tyrosine | 2001 |
Effect of nitrite on endothelial function in isolated lung.
Topics: Animals; Blood Pressure; Capillary Permeability; Carcinogens; Dimethyl Sulfoxide; Endothelium, Vascular; Free Radical Scavengers; Lipopolysaccharides; Lung; Male; Models, Animal; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitrites; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil.
Topics: Arachidonic Acid; Blood Proteins; Flavonoids; Humans; In Vitro Techniques; Luteolin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Quercetin; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
The microtubule cytoskeleton participates in control of beta2 integrin avidity.
Topics: Animals; Antineoplastic Agents; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line; Cell Line, Transformed; Colchicine; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Gout Suppressants; Humans; Integrins; Macrophages; Mice; Microscopy, Video; Microtubules; Models, Statistical; Nocodazole; Paclitaxel; Paxillin; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine | 2001 |
Signal transduction of physiological concentrations of vasopressin in A7r5 vascular smooth muscle cells. A role for PYK2 and tyrosine phosphorylation of K+ channels in the stimulation of Ca2+ spiking.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 2; Ionomycin; Ionophores; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Muscle, Smooth; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasopressins | 2002 |
Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets.
Topics: Adult; Aged; Aging; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Female; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Lectins, C-Type; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; Phosphorylation; Phytohemagglutinins; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2002 |
Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils.
Topics: Apigenin; Disaccharides; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Glucosides; Glucuronides; Humans; Luteolin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Plants, Medicinal; Protein-Tyrosine Kinases; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
Topics: Animals; Cell Line; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glomerular Mesangium; Glucose; Heparin-binding EGF-like Growth Factor; Hexokinase; Immunohistochemistry; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells.
Topics: alpha-Synuclein; Animals; Blood Proteins; Blotting, Western; Brain; Cell Line; Cytoplasm; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Glutathione Transferase; Humans; Microscopy, Fluorescence; Mutation; Nerve Tissue Proteins; Phospholipase D; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Rats; Recombinant Fusion Proteins; Synucleins; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tyrosine; Vanadates | 2002 |
A 45-kDa protein kinase related to mitogen-activated protein kinase is activated in tobacco cells treated with a phorbol ester.
Topics: Cells, Cultured; Cycloheximide; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Weight; Nicotiana; Phosphorylation; Plant Proteins; Serine; Stress, Mechanical; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2002 |
Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway.
Topics: Actins; Cell Line; Enzyme Activation; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); rho GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Differential internalization of the prostaglandin f(2alpha) receptor isoforms: role of protein kinase C and clathrin.
Topics: Cell Line; Clathrin; Dinoprost; Enzyme Activation; Epitopes; Humans; Immunoblotting; Isomerism; Microscopy, Fluorescence; Phosphorylation; Prostaglandin Antagonists; Protein Kinase C; Receptors, Prostaglandin; Sucrose; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Syndecan-4 modulates focal adhesion kinase phosphorylation.
Topics: Animals; Blotting, Western; Cell Adhesion; Cells, Cultured; DNA, Complementary; Fibroblasts; Fibronectins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Kinetics; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proteoglycans; rho GTP-Binding Proteins; Signal Transduction; Syndecan-4; Tetradecanoylphorbol Acetate; Transfection; Tyrosine; Vanadates | 2002 |
The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion.
Topics: Cell Adhesion; Cytochalasin D; Enzyme Activation; Fibronectins; GTPase-Activating Proteins; Humans; Integrin beta1; Jurkat Cells; Leukocytes; Ligands; Nuclear Proteins; Phosphorylation; Protein Kinase C; rap1 GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Protein nitration is predominantly mediated by a peroxynitrite-dependent pathway in cultured human leucocytes.
Topics: Aniline Compounds; Cells, Cultured; Extracellular Space; Humans; Leukocytes; Metalloporphyrins; Nitrates; Peroxidase; Peroxynitrous Acid; Proteins; Spermine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.
Topics: Amino Acid Sequence; Binding Sites; Cell Line; Enzyme Activation; Epitopes; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mutagenesis, Site-Directed; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor-independent thrombin generation.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Blood Platelets; Cells, Cultured; Collagen; Drug Evaluation, Preclinical; Endothelium, Vascular; Eptifibatide; Extracellular Matrix; Factor VIIa; Factor X; Hemorheology; Humans; Immunoglobulin Fab Fragments; Oligopeptides; Peptides; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Prothrombin; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thrombasthenia; Thrombin; Thromboplastin; Tirofiban; Tyrosine | 2003 |
Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.
Topics: Antihypertensive Agents; Blood Proteins; Diospyros; Dose-Response Relationship, Drug; Flavonoids; Hemolysis; Humans; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Plant Leaves; Plant Preparations; Plants, Medicinal; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Effect of S-(1,2-dicarboxyethyl) glutathione and S-(1,2-dicarboxyethyl) cysteine on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.
Topics: Arachidonic Acid; Blood Proteins; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Glutathione; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Lysine; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Point Mutation; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tyrosine | 2003 |
High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species.
Topics: Cells, Cultured; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Epoprostenol; Gene Expression Regulation; Glucose; Humans; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Models, Biological; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane A2; Tyrosine; Up-Regulation | 2003 |
Tyrosine phosphorylation of a novel 100-kDa protein coupled to CD28 in resting human T cells is enhanced by a signal through TCR/CD3 complex.
Topics: Calcimycin; CD28 Antigens; Enzyme Inhibitors; Humans; Immunoblotting; Jurkat Cells; Lymphocyte Activation; Naphthalenes; Phosphoproteins; Phosphorylation; Precipitin Tests; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 2003 |
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement.
Topics: Actins; Animals; Cell Size; Cells, Cultured; Chemotaxis, Leukocyte; Gene Expression Regulation; Macrophages; Mice; Mice, Knockout; Oncogene Protein v-cbl; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-hck; Retroviridae Proteins, Oncogenic; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 2003 |
Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression.
Topics: Amino Acid Sequence; Amino Acid Substitution; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Genetic Vectors; Humans; I-kappa B Kinase; Isoenzymes; Membrane Proteins; Molecular Sequence Data; NF-kappa B; Phenylalanine; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrimidines; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrosine | 2003 |
Urokinase receptor mRNA stability involves tyrosine phosphorylation in lung epithelial cells.
Topics: Benzoquinones; Cell Line; Down-Regulation; Epithelial Cells; Humans; Lactams, Macrocyclic; Lung; Phosphorylation; Quinones; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Rifabutin; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tyrosine | 2004 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Effect of three triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation and tyrosyl phosphorylation and translocation of p47(phox) and p67(phox) to cell membrane in human neutrophil.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Humans; Immunoblotting; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; Plant Roots; Protein Transport; Saponins; Superoxides; Tetradecanoylphorbol Acetate; Triterpenes; Tyrosine | 2003 |
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
Topics: ADAM Proteins; ADAMTS4 Protein; Alitretinoin; Cell Line; Humans; Macrophages; Matrix Metalloproteinase 9; Metalloendopeptidases; Metalloproteases; Oxazoles; Procollagen N-Endopeptidase; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tretinoin; Tyrosine | 2003 |
Pervanadate-induced reverse translocation and tyrosine phosphorylation of phorbol ester-stimulated protein kinase C betaII are mediated by Src-family tyrosine kinases in porcine neutrophils.
Topics: Animals; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Immunoblotting; Neutrophils; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C beta; Protein Transport; Protein Tyrosine Phosphatases; Pyrimidines; src-Family Kinases; Swine; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 2004 |
Signals mediating cleavage of intercellular adhesion molecule-1.
Topics: Alanine; Amino Acid Substitution; Cell Line; Cytoplasm; Embryo, Mammalian; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intercellular Adhesion Molecule-1; Kidney; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Differential role of Janus family kinases (JAKs) in interferon-gamma-induced lung epithelial ICAM-1 expression: involving protein interactions between JAKs, phospholipase Cgamma, c-Src, and STAT1.
Topics: DNA-Binding Proteins; Epithelial Cells; Gene Expression; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Janus Kinase 1; Janus Kinase 2; Lung; Phospholipase C gamma; Phosphorylation; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Messenger; src-Family Kinases; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Type C Phospholipases; Tyrosine | 2004 |
AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bradykinin; Calcium; COS Cells; Enzyme Activation; Gene Library; Glutathione Transferase; Humans; Inositol Phosphates; Isoenzymes; Membrane Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Neoplasm Proteins; NIH 3T3 Cells; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2004 |
The magnitude of TCR engagement is a critical predictor of T cell anergy or activation.
Topics: Actins; Amino Acid Substitution; Animals; Antigen Presentation; Cell Line, Transformed; Clonal Anergy; Clone Cells; Hemagglutinin Glycoproteins, Influenza Virus; HLA-DR1 Antigen; Humans; Interleukin-2; Lymphocyte Activation; Mice; Mice, Transgenic; Peptide Fragments; Phosphorylation; Protein Binding; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.
Topics: Amino Acid Motifs; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Type 2; Glucose; Heterozygote; Humans; Insulin; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2004 |
Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta.
Topics: Amino Acid Sequence; Anesthetics, General; Animals; Binding Sites; Circular Dichroism; Diglycerides; Mice; Models, Molecular; Molecular Sequence Data; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Role of tyrosine phosphorylation in the regulation of cleavage secretion of angiotensin-converting enzyme.
Topics: Animals; Carcinogens; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Heat-Shock Proteins; Kidney; Mass Spectrometry; Mice; Mitogen-Activated Protein Kinases; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Peptidyl-Dipeptidase A; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Structure, Tertiary; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 2004 |
Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive.
Topics: Actins; Animals; B-Lymphocytes; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Cytoskeletal Proteins; Genetic Vectors; Humans; Immunohistochemistry; Immunoprecipitation; Interleukin-3; Lymphocytes; Mice; Microscopy, Fluorescence; Mutation; Paxillin; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Endogenous nitration of iron regulatory protein-1 (IRP-1) in nitric oxide-producing murine macrophages: further insight into the mechanism of nitration in vivo and its impact on IRP-1 functions.
Topics: Aconitate Hydratase; Animals; Blotting, Western; Catechin; Cell Line; Cytoplasm; Cytosol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Hydrogen Peroxide; Interferon-gamma; Iron; Iron Regulatory Protein 1; Iron-Sulfur Proteins; Lipopolysaccharides; Macrophages; Mercaptoethanol; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrogen; Peroxidases; Peroxynitrous Acid; Protein Binding; Recombinant Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Salicylamides; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.
Topics: Animals; Cell Line; Chlorocebus aethiops; Endocytosis; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Metalloendopeptidases; Mice; Mitogen-Activated Protein Kinase 3; Paracrine Communication; Phenylalanine; Phosphorylation; Quinazolines; Rats; Receptors, Somatomedin; Tetradecanoylphorbol Acetate; Thiophenes; Tyrosine; Tyrphostins | 2004 |
Identification of proteins in activated human neutrophils susceptible to tyrosyl radical attack. A proteomic study using a tyrosylating fluorophore.
Topics: Animals; Blotting, Western; Cattle; Electrophoresis, Gel, Two-Dimensional; Fluorescent Dyes; Free Radicals; Humans; Interferon-gamma; Mass Spectrometry; Molecular Sequence Data; Neutrophil Activation; Neutrophils; Peptide Mapping; Proteins; Proteome; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Effects of anesthetic agents on focal adhesion kinase (pp125FAK) tyrosine phosphorylation in rat hippocampal slices.
Topics: Anesthetics; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Hippocampus; Immunoblotting; In Vitro Techniques; Kinetics; Male; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 2004 |
Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.
Topics: Actins; Animals; Antibodies, Phospho-Specific; Cell Line; Cell Surface Extensions; Enzyme Activation; Humans; Immunohistochemistry; Indoles; Maleimides; Microfilament Proteins; Phosphoproteins; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins pp60(c-src); Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 2004 |
Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2.
Topics: Animals; Binding Sites; Cell Line, Transformed; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epitopes; Genes, Dominant; Hydrogen Peroxide; Immunoblotting; Immunoprecipitation; Mice; Models, Biological; NIH 3T3 Cells; Phenylalanine; Phosphorylation; Plasmids; Point Mutation; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; Pyrimidines; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tyrosine | 2004 |
Differential regulation of phospholipase Cgamma subtypes through FcepsilonRI, high affinity IgE receptor.
Topics: Animals; Cell Line; Gene Expression Regulation, Enzymologic; Immunoglobulin E; Isoenzymes; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Subunits; Rats; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate; Two-Hybrid System Techniques; Type C Phospholipases; Tyrosine | 2004 |
Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.
Topics: Acetophenones; Astrocytes; Benzopyrans; Blotting, Western; Butadienes; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Immunoprecipitation; Models, Biological; Nitriles; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; RNA, Small Interfering; src-Family Kinases; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Transcriptional Activation; Tyrosine | 2005 |
Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages.
Topics: Animals; Antioxidants; Cell Line; Cell Survival; Cinnamates; Depsides; Dose-Response Relationship, Drug; I-kappa B Proteins; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Phosphorylation; Reactive Nitrogen Species; Reactive Oxygen Species; Rosmarinic Acid; Serine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2005 |
Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both.
Topics: Animals; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunoprecipitation; Isoenzymes; Macrophage-1 Antigen; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Microglia; Myelin Sheath; Phagocytosis; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Protein Kinase C; Receptors, Drug; Scavenger Receptors, Class A; Signal Transduction; Tetradecanoylphorbol Acetate; Thioglycolates; Tyrosine | 2006 |
Effect of five triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Cells, Cultured; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; rac GTP-Binding Proteins; Serine; Superoxides; Tetradecanoylphorbol Acetate; Threonine; Triterpenes; Tyrosine | 2006 |
Tyrosine phosphorylation on capacitated human sperm tail detected by immunofluorescence correlates strongly with sperm-zona pellucida (ZP) binding but not with the ZP-induced acrosome reaction.
Topics: Acrosome Reaction; Biomarkers; Bucladesine; Female; Fluorescent Antibody Technique; Humans; Infertility, Male; Male; Phosphorylation; Sperm Capacitation; Sperm Tail; Sperm-Ovum Interactions; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; Zona Pellucida | 2006 |
Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside.
Topics: 3T3 Cells; Animals; Blotting, Western; Cell Survival; Cell-Free System; Cells, Cultured; Fibroblasts; Glucosides; Heme; Humans; Hydrogen Peroxide; Hydroquinones; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxynitrous Acid; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 2007 |
Biochemical characterization of reactive nitrogen species by eosinophil peroxidase in tyrosine nitration.
Topics: Animals; Blotting, Western; Eosinophil Peroxidase; Eosinophils; Gastric Mucosa; Histocytochemistry; Immunohistochemistry; Male; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Peritoneum; Rats; Rats, Wistar; Reactive Nitrogen Species; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2007 |
Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling.
Topics: Blood Platelets; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Immunoprecipitation; Phosphorylation; Protein Kinase C-delta; Signal Transduction; src-Family Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases; Tyrosine | 2007 |
MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity.
Topics: Adenoviridae; Animals; Cell Line; Cells, Cultured; Escherichia coli; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Hydrogen Peroxide; Macrophages; MAP Kinase Kinase 6; Mice; Mice, Transgenic; Mutation; Oxidants; Phosphorylation; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2007 |
The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-beta on matrix metalloproteinase-9 expression.
Topics: Binding Sites; Cell Line, Tumor; Gene Expression; HeLa Cells; Humans; Immunoblotting; Interferon-beta; Interferon-Stimulated Gene Factor 3; Interferon-Stimulated Gene Factor 3, gamma Subunit; Luciferases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; STAT2 Transcription Factor; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tyrosine | 2007 |
Posttranslational modifications on protein kinase c isozymes. Effects of epinephrine and phorbol esters.
Topics: Acetylglucosamine; Animals; Enzyme Activation; Epinephrine; Hepatocytes; Isoenzymes; Male; Mass Spectrometry; Protein Kinase C; Protein Processing, Post-Translational; Rats; Rats, Wistar; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2008 |
Phorbol 12-myristate 13-acetate-dependent protein kinase C delta-Tyr311 phosphorylation in cardiomyocyte caveolae.
Topics: Animals; Cyclodextrins; Endothelins; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Myocardium; Myocytes, Cardiac; Norepinephrine; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-abl; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Tyrosine | 2008 |
Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species.
Topics: Animals; Bicarbonates; Catechin; Cattle; Fibroblasts; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Macrophages; Mice; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Peroxynitrous Acid; Quinic Acid; Reactive Nitrogen Species; Serum Albumin, Bovine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tyrosine | 2008 |
Enhancement of sperm-zona pellucida (ZP) binding capacity by activation of protein kinase A and C pathways in certain infertile men with defective sperm-ZP binding.
Topics: Acrosome Reaction; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Female; Humans; Infertility, Male; Male; Phosphorylation; Protein Kinase C; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; Tetradecanoylphorbol Acetate; Tyrosine | 2009 |
Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Cell Membrane; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Immunoprecipitation; Molecular Sequence Data; Phosphorylation; Protein Kinase C; src-Family Kinases; Tetradecanoylphorbol Acetate; TRPV Cation Channels; Tyrosine | 2009 |
T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.
Topics: Adenosine Triphosphate; Animals; Enzyme Activation; Humans; Kinetics; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Antigen, T-Cell; Recombinant Proteins; Signal Transduction; Substrate Specificity; T-Lymphocytes; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2009 |
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Topics: Animals; Cell Line; Cell Movement; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblasts; Focal Adhesion Kinase 1; Insulin-Like Growth Factor I; Lysophospholipids; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2009 |
PPARgamma agonists inhibit angiogenesis by suppressing PKCalpha- and CREB-mediated COX-2 expression in the human endothelium.
Topics: Angiogenesis Inhibitors; Anilides; Benzhydryl Compounds; Benzophenones; Binding Sites; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Down-Regulation; Endothelial Cells; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Humans; Neovascularization, Physiologic; Nitrobenzenes; PPAR gamma; Promoter Regions, Genetic; Protein Kinase C-alpha; Protein Transport; RNA Interference; RNA, Messenger; Rosiglitazone; Sulfonamides; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transfection; Tyrosine; Vascular Endothelial Growth Factor A | 2010 |
Postsynaptic clustering and activation of Pyk2 by PSD-95.
Topics: Animals; Animals, Newborn; Antibodies; Brain; Calcium; Calmodulin; Cell Line, Transformed; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Focal Adhesion Kinase 2; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Ionomycin; Ionophores; Male; Membrane Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; PDZ Domains; Phosphorylation; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Tetradecanoylphorbol Acetate; Tetrodotoxin; Transfection; Tyrosine | 2010 |
PKC alpha phosphorylates cytosolic NF-kappaB/p65 and PKC delta delays nuclear translocation of NF-kappaB/p65 in U1242 glioblastoma cells.
Topics: Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glioblastoma; Humans; Indoles; Maleimides; NF-kappa B; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 2010 |
Insulin stimulation of PKCδ triggers its rapid degradation via the ubiquitin-proteasome pathway.
Topics: Amino Acid Substitution; Animals; Blotting, Western; Cell Line; Cysteine Proteinase Inhibitors; Hypoglycemic Agents; Insulin; Leupeptins; Muscle, Skeletal; Myoblasts; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Ubiquitin; Ubiquitination | 2010 |
Anti-inflammatory properties of clovamide and Theobroma cacao phenolic extracts in human monocytes: evaluation of respiratory burst, cytokine release, NF-κB activation, and PPARγ modulation.
Topics: Anti-Inflammatory Agents; Cacao; Cinnamates; Cytokines; Depsides; Hot Temperature; Humans; Monocytes; NF-kappa B; Phenols; Plant Extracts; PPAR gamma; Respiratory Burst; Rosmarinic Acid; Seeds; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2011 |
Correlation between EGFR Y1068 tyrosine phosphorylation and AP-1 activation by tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin.
Topics: Animals; Carcinogens; Catalytic Domain; Enzyme Activation; ErbB Receptors; Female; JNK Mitogen-Activated Protein Kinases; Mice; Phosphorylation; Signal Transduction; Skin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tyrosine | 2012 |
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Topics: Angiotensin II; Animals; Cattle; Cell Line; Endothelial Cells; Enzyme Activation; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Zucker; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 2013 |
Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC.
Topics: Acetylcysteine; Adherens Junctions; Antigens, CD; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Breast Neoplasms; Cadherins; Cell Movement; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Male; Ovarian Neoplasms; Plant Extracts; Prostatic Neoplasms; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 2013 |