Compounds > tetradecanoylphorbol acetate
Page last updated: 2024-08-23

tetradecanoylphorbol acetate and tacrolimus

tetradecanoylphorbol acetate has been researched along with tacrolimus in 100 studies

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.00)18.7374
1990's67 (67.00)18.2507
2000's26 (26.00)29.6817
2010's4 (4.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morikawa, K; Morikawa, S; Oseko, F1
Bergstrand, H; Eriksson, T; Hallberg, A; Johansson, B; Karabelas, K; Michelsen, P; Nybom, A1
Andersson, J; Andersson, U; Groth, CG; Nagy, S2
Kincaid, RL; O'Keefe, SJ; O'Neill, EA; Tamura, J; Tocci, MJ1
Cohen, N; Dawson, TM; Fotuhi, M; Glatt, CE; Snowman, AM; Snyder, SH; Steiner, JP1
Bierer, BE; Calvo, V; Crews, CM; Vik, TA1
Avruch, J; Bierer, BE; Calvo, V; Grove, JR; Price, DJ1
Liu, J; Sakane, T; Tsunematsu, T1
Dumont, FJ; Koprak, SL; Melino, MR; Sigal, NH; Staruch, MJ1
Dumont, FJ; Fischer, PA; Koprak, SL; Melino, MR; Sigal, NH; Staruch, MJ1
Bach, FH; Duquesnoy, RJ; Eiras, G; Fung, JJ; Starzl, T; Todo, S; Zeevi, A1
Granelli-Piperno, A; Inaba, K; Nolan, P; Steinman, RM1
Duquesnoy, RJ; Eiras, G; Shimizu, Y; van Seventer, GA; Zeevi, A1
Boltz, RC; Lin, CS; Siekierka, JJ; Sigal, NH1
Lin, CS; Siekierka, JJ; Sigal, NH1
Banerji, SS; Parsons, JN; Tocci, MJ1
Forrest, MJ; Jewell, ME; Koo, GC; Sigal, NH1
Semerjian, A; Su, MS1
Cairns, JS; Mainwaring, MS; McCarthy, SA1
Strednak, J; Thomson, AW; Todo, S; Woo, J; Yao, GZ; Zeevi, A1
Kawase, Y; Sawada, S; Suzuki, G; Takaku, F1
Gschwendt, M; Kittstein, W; Marks, F1
Benzie, CR; Doe, SE; Kay, JE1
Clipstone, NA; Crabtree, GR1
Fenton, M; Kay, JE1
Horiguchi, H; Ishikawa, Y; Matsushima, K; Mukaida, N; Murakami, S; Okamoto, S; Rice, N; Yasumoto, K1
Bonnefoy-Berard, N; Dearden-Badet, MT; Genestier, L; Lizard, G; Revillard, JP1
Bong, JM; Kobayashi, Y; Ohmoto, Y; Ohsaka, Y; Oka, T; Yasui, H; Yoshimura, N1
Chang, CH; Furue, M; Osada, A; Tamaki, K1
Alexander, D; Metcalfe, S; Turner, J1
Mouzaki, A; Rungger, D1
Adams, DH; Burnett, D; Grant, RA; Liu, Q; Lord, JM; Martin, TJ; Stockley, RA1
Blenis, J; Cheatham, L; Chung, J; Grammer, TC; Lemon, KP; Monfar, M; Vlahos, CJ1
Heike, T; Jung, EY; Kawai, M; Mayumi, M; Nishikomori, R; Tai, G; Yamanaka, C1
Burakoff, SJ; Sen, R; Venkataraman, L1
Iseki, R; Iwata, M; Mukai, M; Tozawa, Y; Zhao, Y1
Higer, M; Teutsch, M; Wang, D; Wortis, HW1
Ito, K; Kaminuma, O; Kobayashi, S; Matsuzaki, G; Mori, A; Nishizaki, Y; Okudaira, H; Suko, M; Tsuruoka, N; Yamamoto, K1
Dennis, PB; Han, JW; Pearson, RB; Thomas, G1
Benacerraf, B; Freeman, GJ; Galvin, F; Nadler, L; Razi-Wolf, Z; Reiser, H1
Jiang, H; Kato, R; Nishikawa, K; Yamamoto, S1
Duquesnoy, RJ; Fung, JJ; Starzl, TE; Todo, S; Venkataramanan, R; Yao, GZ; Zeevi, A1
Chowdhury, P; Doi, R; Inoue, K; Kaji, H; Rayford, PL1
Altmeyer, A; Dumont, FJ1
Bondada, S; Muthukkumar, S; Udhayakumar, V1
Brooks, N; Ryffel, B; Willcocks, JL; Woerly, G1
Handschumacher, RE; Li, W1
Myburgh, JA; Smit, JA; Stark, JH1
Adams, DH; Liu, Q1
Sheppard, KE1
Ichida, T; Obinata, T; Takuma, T; Tamura, S; Yokoyama, N1
Blenis, J; Monfar, M1
Asakura, Y; Hosino, A; Kaminuma, O; Mikami, T; Mori, A; Nagahori, T; Nishizaki, Y; Ohmura, T; Okudaira, H; Suko, M1
Aoki, Y; Kao, PN1
Leach, KL; Ruff, VA; Scott, JE1
Bragado, MJ; Groblewski, GE; Williams, JA1
Adamson, J; Aebersold, RH; Brien, JH; Burns, GF; Dorahy, DJ; Jin, B; Lloyd, J; Scott, JL; Sherrington, PD; Simmons, D; Zuzel, M1
Camacho, R; DaSilva, C; Dumont, FJ; Fischer, P; Staruch, MJ1
Cardoso, CM; De Meis, L; Rumjanek, VM1
Asada, A; Iwata, M; Kuwata, T; Miyaike, M; Mukai, M; Ohoka, Y1
Azuma, H; Ichimaru, N; Kokado, Y; Li, BS; Matsumiya, K; Miki, T; Nonomura, N; Okuyama, A; Suzuki, S; Takahara, S; Wang, JD1
Onose, J; Sawada, J; Teshima, R1
Camacho, R; Dumont, FJ; Staruch, MJ1
Ballaron, SJ; Bauch, J; Carter, G; Chen, YW; Djuric, S; Fey, TA; Gauvin, DM; Hsieh, GC; Kolano, R; Luly, J; Marsh, K; Mollison, KW; Pong, MS; Sheets, MP; Smith, ML; Trevillyan, JM1
Benedict, SH; Branden, M; Chan, MA; Jung, M; Kohlmeier, JE1
Ahlers, C; Kreideweiss, S; Nordheim, A; Rühlmann, A1
Hampel, G; Hosseini, R; Jung, K1
Miyamoto, S; Safer, B1
Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M1
Bakker, AQ; Hooijberg, E; Ruizendaal, JJ; Spits, H1
Bao, HF; Eaton, DC; Edinger, RS; Johnson, JP; Yue, G1
Kimball, SR; Miyamoto, S; Safer, B1
Fong, CW; Lin, SC; Neo, SY; Zhang, Y1
Clipstone, NA; Riggins, PS1
Blauvelt, A; Davis, DA; Moses, AV; Orenstein, JM; Overwijk, WW; Rinderknecht, AS; Yarchoan, R; Zoeteweij, JP1
Barbeau, B; Fortin, JF; Lemieux, AM; Paré , ME; Robichaud, GA; Tremblay, MJ1
Barten, MJ; Gummert, JF; Morris, RE; Shorthouse, R; van Gelder, T1
Ahmed, M; Bartley, GP; Dodson, FS; Fung, JJ; Logar, AJ; Rao, AS; Robert, K; Shapiro, R; Venkataraman, R; Zeevi, A1
Chong, SU; Grassberger, M; Grunow, K; Guhl, S; Henz, BM; Welker, P; Zuberbier, T1
Almawi, WY; Assi, JW; Chudzik, DM; Jaoude, MM; Rieder, MJ1
Al-Daraji, WI; Grant, KR; Reynolds, NJ; Ryan, K; Saxton, A1
Ahn, JS; Ahn, SC; Choe, YK; Kang, DO; Kim, BY; Mheen, TI; Oh, WK; Park, YM1
Hommes, M; Ijzermans, JN; Kwekkeboom, J; Metselaar, HJ; Tilanus, HW; Van Rijen, MM1
Courjaret, R; Grolleau, F; Lapied, B1
Cao, X; Ishiguro, N; Kambe, F; Mitsuyama, H; Murakami, R; Seo, H1
Kim, E; Kim, TS; Lee, MH1
Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L1
Iwata, Y; Katanosaka, Y; Kobayashi, Y; Shibasaki, F; Shigekawa, M; Wakabayashi, S1
Cameron, P; Kanke, T; Macfarlane, SR; McKenzie, RC; Plevin, R; Sloss, CM1
Adiri, Y; Boss, JM; Evavold, BD; Kumar, S; Lukacher, AE; Skeen, MJ; Vezys, VD; Yoon, H; Ziegler, HK1
Canellada, A; Cano, E; Redondo, JM; Sánchez-Ruiloba, L; Zafra, F1
Böhler, T; Budde, K; Glander, P; Gurragchaa, P; Kamar, N; Klupp, J; Neumayer, HH; Nolting, J; Reisener, K1
Aherne, SA; O'Brien, NM1
Cárcamo, JG; Claude, A; Ojeda, D; Quezada, C; Rauch, MC; Salas, M; San Martín, A; Slebe, JC; Yañez, AJ1
Hantash, BM; Reeves, JP; Thomas, AP; Turner, JD1
Barnett, NL; Gole, GA; Holcombe, DJ1
Fujii, T; Kawashima, K; Takada-Takatori, Y1
Baan, CC; Cadogan, MM; Hesselink, DA; Vafadari, R; Weimar, W1
Maguire, O; Minderman, H; O'Loughlin, KL; Tornatore, KM; Venuto, RC1

Reviews

1 review(s) available for tetradecanoylphorbol acetate and tacrolimus

ArticleYear
Enhanced production and gene expression of IL-5 in bronchial asthma. Possible management of atopic diseases with IL-5 specific gene transcription inhibitor.
    Advances in experimental medicine and biology, 1996, Volume: 409

    Topics: Animals; Asthma; CD4-Positive T-Lymphocytes; Cyclosporine; Gene Expression; Humans; Interleukin-5; Ionomycin; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic

1996

Trials

1 trial(s) available for tetradecanoylphorbol acetate and tacrolimus

ArticleYear
Inhibitory effect of tacrolimus on p38 mitogen-activated protein kinase signaling in kidney transplant recipients measured by whole-blood phosphospecific flow cytometry.
    Transplantation, 2012, Jun-27, Volume: 93, Issue:12

    Topics: Adult; Carcinogens; Dose-Response Relationship, Drug; Female; Flow Cytometry; Graft Rejection; Humans; Immunosuppressive Agents; Jurkat Cells; Kidney Transplantation; Male; MAP Kinase Signaling System; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

2012

Other Studies

98 other study(ies) available for tetradecanoylphorbol acetate and tacrolimus

ArticleYear
The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes.
    Transplantation, 1992, Volume: 54, Issue:6

    Topics: Antibody-Producing Cells; B-Lymphocytes; Cell Differentiation; Cell Line; DNA; Humans; Immunoglobulins; Kinetics; Leukocyte Count; Lymphocyte Activation; RNA; Staphylococcus aureus; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors

1992
Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: Amino Acid Isomerases; Basophils; Calmodulin; Carbazoles; Carrier Proteins; Diacylglycerol Kinase; Histamine Release; Humans; Indole Alkaloids; Myosin-Light-Chain Kinase; Neutrophils; Peptidylprolyl Isomerase; Phosphotransferases; Protein Kinase C; Pyrimidinones; Superoxides; Tacrolimus; Tetradecanoylphorbol Acetate; Thiazoles

1992
FK 506 and cyclosporine inhibit antigen- or mitogen-induced monokine and lymphokine production in vitro.
    Transplantation proceedings, 1992, Volume: 24, Issue:1

    Topics: Cells, Cultured; Cyclosporine; Cytokines; Dose-Response Relationship, Drug; Enterotoxins; Fluorescent Antibody Technique; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukin-5; Ionomycin; Kinetics; Leukocytes, Mononuclear; Lymphokines; Lymphotoxin-alpha; Staphylococcus aureus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

1992
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin.
    Nature, 1992, Jun-25, Volume: 357, Issue:6380

    Topics: Animals; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Chloramphenicol O-Acetyltransferase; Chromosome Deletion; Cyclosporine; Gene Expression Regulation; Humans; Interleukin-2; Ionomycin; Kinetics; Macromolecular Substances; Mice; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Promoter Regions, Genetic; Recombinant Proteins; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection

1992
High brain densities of the immunophilin FKBP colocalized with calcineurin.
    Nature, 1992, Aug-13, Volume: 358, Issue:6387

    Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Calcineurin; Calcium; Calmodulin-Binding Proteins; Carrier Proteins; Cell Membrane; Cyclosporine; Molecular Weight; Organ Specificity; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Rats; Sulfur Radioisotopes; Tacrolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate; Tritium

1992
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Aug-15, Volume: 89, Issue:16

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Immunoblotting; Immunosuppressive Agents; Interleukin-2; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tyrosine

1992
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.
    Science (New York, N.Y.), 1992, Aug-14, Volume: 257, Issue:5072

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Cyclosporine; Immunosuppressive Agents; Insulin; Kinetics; Liver Neoplasms, Experimental; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Transfection

1992
The effects of FK-506 and cyclosporin A on the proliferation of PHA-stimulated T cells in response to IL-2, IL-4 or IL-6.
    International archives of allergy and immunology, 1992, Volume: 98, Issue:4

    Topics: Cells, Cultured; Cyclosporine; Humans; Interleukins; Kinetics; Lymphocyte Activation; Phytohemagglutinins; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1992
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Jan-01, Volume: 144, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Cyclosporins; Hybridomas; Immunosuppressive Agents; Interleukin-2; Interleukin-4; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Polyenes; Receptors, Interleukin-2; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate

1990
The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.
    Journal of immunology (Baltimore, Md. : 1950), 1990, Feb-15, Volume: 144, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Binding, Competitive; Cyclosporins; Gene Expression; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Polyenes; Receptors, Interleukin-2; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1990
Functional differentiation of human cytotoxic T lymphocytes in the presence of FK 506 and CyA.
    Transplantation proceedings, 1990, Volume: 22, Issue:1

    Topics: Anti-Bacterial Agents; Calcimycin; Cell Differentiation; Cyclosporins; Cytotoxicity, Immunologic; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Phytohemagglutinins; T-Lymphocytes, Cytotoxic; Tacrolimus; Tetradecanoylphorbol Acetate

1990
The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.
    The Journal of experimental medicine, 1990, Dec-01, Volume: 172, Issue:6

    Topics: Anti-Bacterial Agents; Base Sequence; Cell Nucleus; Cells, Cultured; Cyclosporins; Dexamethasone; DNA-Binding Proteins; HeLa Cells; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Molecular Sequence Data; Oligonucleotide Probes; Promoter Regions, Genetic; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1990
Effects of FK 506 and cyclosporine on T-cell activation: integrin-mediated adhesion of T cells, proliferation, and maturation of cytotoxic T cells.
    Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 2

    Topics: Anti-Bacterial Agents; Antigens, Differentiation, T-Lymphocyte; Calcimycin; CD3 Complex; CD4-Positive T-Lymphocytes; Cell Adhesion; Cell Adhesion Molecules; Cyclosporins; Cytotoxicity, Immunologic; Fibronectins; Humans; Immunosuppressive Agents; In Vitro Techniques; Integrins; Intercellular Adhesion Molecule-1; Laminin; Lymphocyte Activation; Receptors, Antigen, T-Cell; T-Lymphocytes, Cytotoxic; Tacrolimus; Tetradecanoylphorbol Acetate

1991
FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes.
    Cellular immunology, 1991, Apr-01, Volume: 133, Issue:2

    Topics: Anti-Bacterial Agents; Antigens, Differentiation, T-Lymphocyte; Calcium; CD2 Antigens; CD28 Antigens; CD3 Complex; Cells, Cultured; Cyclosporins; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1991
Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A.
    Transplantation proceedings, 1991, Volume: 23, Issue:2 Suppl 2

    Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antifungal Agents; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Cells, Cultured; Cyclosporins; Drug Interactions; Humans; Interleukin-2; Ionomycin; Lymphocyte Activation; Polyenes; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1991
The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1.
    Molecular and cellular biology, 1991, Volume: 11, Issue:8

    Topics: Anti-Bacterial Agents; Base Sequence; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Concanavalin A; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-2; Ionomycin; Kinetics; Molecular Sequence Data; NF-kappa B; Oligonucleotide Probes; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Retroviridae; Tacrolimus; TATA Box; Tetradecanoylphorbol Acetate

1991
FK-506 and cyclosporin A: selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation.
    Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6

    Topics: Anti-Bacterial Agents; Calcimycin; Cycloheximide; Cyclosporins; Dactinomycin; Humans; Immune Tolerance; Ionomycin; Lactoferrin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polyenes; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate

1991
Activation of transcription factor NF kappa B in Jurkat cells is inhibited selectively by FK 506 in a signal-dependent manner.
    Transplantation proceedings, 1991, Volume: 23, Issue:6

    Topics: Base Sequence; Cell Line; Cyclosporine; Humans; Immunosuppressive Agents; Ionomycin; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Polyenes; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic

1991
The effects of FK 506 on cytokine production are dependent on the mode of cell activation.
    Transplantation proceedings, 1991, Volume: 23, Issue:6

    Topics: Antibodies; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Enterotoxins; Escherichia coli; Humans; Ionomycin; Kinetics; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; Staphylococcus aureus; Tacrolimus; Tetradecanoylphorbol Acetate

1991
Effects of FK 506 and cyclosporine on T-cell tolerance: inhibition of a "protective" mechanism that regulates activation-induced apoptosis in developing thymocytes.
    Transplantation proceedings, 1991, Volume: 23, Issue:6

    Topics: Animals; Calcimycin; Cell Death; Cells, Cultured; Cyclosporine; DNA; Immune Tolerance; Mice; Mice, Inbred C57BL; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1991
Effects of FK 506, mycophenolic acid, and bredinin on OKT-3-, PMA-, and alloantigen-induced activation molecule expression on cultured CD4+ and CD8+ human lymphocytes.
    Transplantation proceedings, 1991, Volume: 23, Issue:6

    Topics: CD4 Antigens; CD8 Antigens; Cells, Cultured; Humans; Immunosuppressive Agents; Isoantigens; Lymphocyte Activation; Muromonab-CD3; Mycophenolic Acid; Receptors, Interleukin-2; Ribonucleosides; T-Lymphocyte Subsets; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1991
Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.
    Journal of immunology (Baltimore, Md. : 1950), 1987, Sep-15, Volume: 139, Issue:6

    Topics: Animals; Antigens; Calcimycin; Cell Line; Concanavalin A; Cyclosporins; Drug Synergism; Immunosuppressive Agents; Interleukin-2; Isoantigens; Lymphocyte Activation; Mice; Pyridines; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Tacrolimus; Tetradecanoylphorbol Acetate

1987
The immunosuppressant FK-506, like cyclosporins and didemnin B, inhibits calmodulin-dependent phosphorylation of the elongation factor 2 in vitro and biological effects of the phorbol ester TPA on mouse skin in vivo.
    Immunobiology, 1989, Volume: 179, Issue:1

    Topics: Animals; Binding Sites; Calmodulin; Cyclosporins; Depsipeptides; Female; Immunosuppressive Agents; In Vitro Techniques; Mice; Peptide Elongation Factor 2; Peptide Elongation Factors; Peptides, Cyclic; Phosphorylation; Pyridines; Skin; Tacrolimus; Tetradecanoylphorbol Acetate

1989
The mechanism of action of the immunosuppressive drug FK-506.
    Cellular immunology, 1989, Volume: 124, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Calcimycin; Calcium; Cyclosporins; Immunosuppressive Agents; Lymphocyte Activation; Protein Kinase C; Swine; Tacrolimus; Tetradecanoylphorbol Acetate

1989
Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506.
    Annals of the New York Academy of Sciences, 1993, Nov-30, Volume: 696

    Topics: Calcineurin; Calmodulin-Binding Proteins; Cell Line; Cyclosporine; DNA-Binding Proteins; Humans; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Phosphoprotein Phosphatases; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic

1993
Thapsigargin activates lymphocytes via a different pathway from ionomycin.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: Animals; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Ionomycin; Kinetics; Lymphocyte Activation; Lymphocytes; Protein Kinase C; Protein Kinases; Signal Transduction; Swine; Tacrolimus; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin

1993
The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
    The Journal of biological chemistry, 1994, Mar-18, Volume: 269, Issue:11

    Topics: Base Sequence; Binding Sites; Calcium; Cell Line; Chloramphenicol O-Acetyltransferase; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Interleukin-8; Ionomycin; Kinetics; Leukemia, T-Cell; Luciferases; Molecular Sequence Data; NF-kappa B; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Sequence Deletion; Suppression, Genetic; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured

1994
Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line.
    Cellular immunology, 1994, Volume: 155, Issue:2

    Topics: Animals; Apoptosis; Calcium; Cross-Linking Reagents; Cyclosporine; Immunoglobulin M; Immunosuppressive Agents; Ionomycin; Lymphoma, B-Cell; Mice; Polyenes; Receptors, Antigen, B-Cell; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1994
The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro.
    Transplantation, 1994, Jun-27, Volume: 57, Issue:12

    Topics: Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin M; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Lipopolysaccharides; Macrophages; Polyenes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate

1994
Immunosuppressive effects of azelastine hydrochloride on contact hypersensitivity and T-cell proliferative response: a comparative study with FK-506.
    The Journal of investigative dermatology, 1994, Volume: 103, Issue:1

    Topics: Administration, Topical; Animals; Bronchodilator Agents; Cell Division; Cells, Cultured; Dermatitis, Contact; DNA; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Phthalazines; Receptors, Interleukin-2; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Tritium

1994
FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal.
    Cellular immunology, 1994, Oct-01, Volume: 158, Issue:1

    Topics: Amino Acid Sequence; Animals; Antigens; Calcineurin; Calcium; Calmodulin-Binding Proteins; Cell Division; Cell Line; Cyclosporine; Cytoplasm; Humans; Interleukin-2; Ionomycin; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Molecular Sequence Data; Muramidase; Phosphoprotein Phosphatases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1994
Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory T-helper cells.
    Blood, 1994, Oct-15, Volume: 84, Issue:8

    Topics: Animals; Base Sequence; Binding Sites; Cyclosporine; DNA; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Interleukin-2; Ionomycin; Molecular Sequence Data; NFATC Transcription Factors; Nuclear Proteins; Oocytes; Promoter Regions, Genetic; Simplexvirus; T-Lymphocytes, Helper-Inducer; Tacrolimus; Tetradecanoylphorbol Acetate; Thymidine Kinase; Transcription Factors; Transcription, Genetic; Xenopus

1994
Inhibition by FK506 of formyl peptide-induced neutrophil activation and associated protein synthesis.
    Biochemical pharmacology, 1994, Sep-15, Volume: 48, Issue:6

    Topics: Calcium; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Protein Biosynthesis; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Superoxides; Tacrolimus; Tetradecanoylphorbol Acetate

1994
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.
    Molecular and cellular biology, 1995, Volume: 15, Issue:1

    Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Interleukin-2; Lymphocytes; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Interleukin-2; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin

1995
Pyrrolidine dithiocarbamate inhibits intercellular adhesion molecule-1 biosynthesis induced by cytokines in human fibroblasts.
    Journal of immunology (Baltimore, Md. : 1950), 1995, Mar-01, Volume: 154, Issue:5

    Topics: Base Sequence; Cell Line; Cyclosporine; Cytokines; Dexamethasone; DNA; Fibroblasts; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Molecular Sequence Data; NF-kappa B; Promoter Regions, Genetic; Pyrrolidines; Recombinant Proteins; RNA, Messenger; Tacrolimus; Tetradecanoylphorbol Acetate; Thiocarbamates

1995
FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.
    The Journal of experimental medicine, 1995, Mar-01, Volume: 181, Issue:3

    Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Calcineurin; Calmodulin-Binding Proteins; Ionomycin; Mice; Molecular Sequence Data; NF-kappa B; Phosphoprotein Phosphatases; Polyenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, Interleukin-1; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1995
Calcineurin activation protects T cells from glucocorticoid-induced apoptosis.
    Journal of immunology (Baltimore, Md. : 1950), 1995, Jun-15, Volume: 154, Issue:12

    Topics: Animals; Apoptosis; Base Sequence; Calcineurin; Calcium; Calmodulin-Binding Proteins; Dexamethasone; DNA, Complementary; Drug Interactions; Hybridomas; In Vitro Techniques; Ionomycin; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Phosphoprotein Phosphatases; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transfection

1995
Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin.
    International immunology, 1995, Volume: 7, Issue:3

    Topics: Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Autoimmunity; B-Lymphocytes; Carrier Proteins; CD5 Antigens; Cell Cycle; Cyclosporine; DNA-Binding Proteins; Gene Expression Regulation; Heat-Shock Proteins; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred CBA; NFATC Transcription Factors; Nuclear Proteins; Polyenes; Sirolimus; T-Lymphocyte Subsets; Tacrolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic

1995
IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A.
    International immunology, 1995, Volume: 7, Issue:3

    Topics: Adult; Animals; Antigens, Dermatophagoides; Asthma; Base Sequence; Beclomethasone; Calcium; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Glycoproteins; Humans; Hypersensitivity, Immediate; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukin-5; Ionomycin; Lymphocyte Activation; Mites; Molecular Sequence Data; Protein Kinase C; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate

1995
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
    The Journal of biological chemistry, 1995, Sep-08, Volume: 270, Issue:36

    Topics: 3T3 Cells; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Blood; Immunosuppressive Agents; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Oligodeoxyribonucleotides; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin

1995
Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen.
    European journal of immunology, 1993, Volume: 23, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; B7-1 Antigen; CD3 Complex; CD4-Positive T-Lymphocytes; Cells, Cultured; CHO Cells; Cricetinae; Cyclosporine; Immunosuppressive Agents; Lymphocyte Activation; Mice; Pyrans; Tacrolimus; Tetradecanoylphorbol Acetate

1993
Anti-tumor-promoting action of FK506, a potent immunosuppressive agent.
    Carcinogenesis, 1993, Volume: 14, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Dermatitis, Contact; Enzyme Induction; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phosphorylation; Skin Neoplasms; Tacrolimus; Tetradecanoylphorbol Acetate

1993
Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1

    Topics: Aspartic Acid; Biphenyl Compounds; Calcimycin; Cells, Cultured; Cyclosporine; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Lymphocytes; Mycophenolic Acid; Phosphonoacetic Acid; Ribonucleosides; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Structural and functional changes of exocrine pancreas induced by FK506 in rats.
    Gastroenterology, 1993, Volume: 104, Issue:4

    Topics: Amylases; Analysis of Variance; Animals; Atropine; Body Weight; Calcimycin; Calcium; Carbachol; Cholecystokinin; Colforsin; Cytosol; Dose-Response Relationship, Drug; Feeding Behavior; Kinetics; Male; N-Methylscopolamine; Pancreas; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Reference Values; Scopolamine; Scopolamine Derivatives; Secretin; Sincalide; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Trypsinogen; Vasoactive Intestinal Peptide

1993
Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma.
    Cytokine, 1993, Volume: 5, Issue:2

    Topics: Animals; Cell Division; Cell Line; Interferon-gamma; Interleukin-1; Ionomycin; Mice; Polyenes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993
Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma.
    European journal of immunology, 1993, Volume: 23, Issue:10

    Topics: Animals; Antibodies, Anti-Idiotypic; Calcium; Cell Division; Cyclosporine; Cytosol; Immunoglobulin M; Ionomycin; Lipopolysaccharides; Lymphoma, B-Cell; Mice; Mice, Inbred CBA; Tacrolimus; Tetradecanoylphorbol Acetate

1993
Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation.
    Immunopharmacology, 1995, Volume: 30, Issue:3

    Topics: Cells, Cultured; Cyclosporine; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Polyenes; Receptors, Interleukin-2; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic

1995
Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones.
    Biochemical and biophysical research communications, 1996, Feb-06, Volume: 219, Issue:1

    Topics: Alkaline Phosphatase; Bucladesine; Clone Cells; Colforsin; Cyclosporine; Dinoprostone; DNA-Binding Proteins; Enzyme Inhibitors; Ethers, Cyclic; Female; Humans; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Marine Toxins; NFATC Transcription Factors; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Protein Phosphatase 1; Recombinant Proteins; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured

1996
Induction of primate TH2 lymphokines to suppress TH1 cells.
    Transplantation proceedings, 1996, Volume: 28, Issue:2

    Topics: Animals; Cells, Cultured; Cholera Toxin; Colforsin; Enzyme Activation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Interleukin-2; Interleukin-4; Ionomycin; Lymphokines; Papio; Protein Kinase C; Tacrolimus; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells; Virulence Factors, Bordetella

1996
FK506 inhibits human lymphocyte migration and the production of lymphocyte chemotactic factors in liver allograft recipients.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:6

    Topics: Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Migration Inhibition; Cell Movement; Chemotactic Factors; Graft Rejection; Humans; Immunosuppressive Agents; In Vitro Techniques; Liver Transplantation; Lymphocyte Activation; Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1996
Cyclosporin A and FK506 are potent activators of proopiomelanocortin-derived peptide secretion without affecting corticotrope glucocorticoid receptor function.
    Journal of neuroendocrinology, 1995, Volume: 7, Issue:11

    Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Gene Expression; Male; Mice; Peptides; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; RNA, Heterogeneous Nuclear; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured

1995
Dephosphorylation of cofilin in parotid acinar cells.
    Journal of biochemistry, 1996, Volume: 120, Issue:1

    Topics: Actin Depolymerizing Factors; Amylases; Animals; Calcimycin; Calcium; Carbachol; Cyclic AMP; Cyclosporine; Enzyme Inhibitors; Exocytosis; Ionophores; Isoproterenol; Marine Toxins; Microfilament Proteins; Nerve Tissue Proteins; Oxazoles; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Rats; Tacrolimus; Tetradecanoylphorbol Acetate

1996
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.
    Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Anti-Inflammatory Agents; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucocorticoids; Interleukin-2; Marine Toxins; Mice; Oxazoles; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic

1996
Cyclosporin A-sensitive calcium signaling represses NFkappaB activation in human bronchial epithelial cells and enhances NFkappaB activation in Jurkat T-cells.
    Biochemical and biophysical research communications, 1997, May-19, Volume: 234, Issue:2

    Topics: Base Sequence; Bronchi; Calcium; Cell Line, Transformed; Cyclosporine; Epithelium; Genes, Reporter; Humans; Inflammation; Ionomycin; Jurkat Cells; Luciferases; NF-kappa B; Oligonucleotide Probes; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection

1997
Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells.
    The Biochemical journal, 1997, Jun-01, Volume: 324 ( Pt 2)

    Topics: Animals; Calcineurin; Calmodulin-Binding Proteins; Cell Line; Cell Nucleus; Cold Temperature; DNA-Binding Proteins; Enzyme Inhibitors; Immunosuppressive Agents; Indoles; Ionomycin; Ionophores; Kinetics; Lymphocyte Activation; Maleimides; Mice; NFATC Transcription Factors; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Staurosporine; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors

1997
p70s6k is activated by CCK in rat pancreatic acini.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1

    Topics: Amino Acid Sequence; Androstadienes; Animals; Bombesin; Carbachol; Cells, Cultured; Cholecystokinin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Genistein; Ionomycin; Isoflavones; Kinetics; Male; Molecular Sequence Data; Pancreas; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Thionucleotides; Vasoactive Intestinal Peptide; Wortmannin

1997
TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression.
    The Journal of biological chemistry, 1997, Aug-29, Volume: 272, Issue:35

    Topics: Amino Acid Sequence; Animals; Antigens, Differentiation, T-Lymphocyte; Base Sequence; Cell Differentiation; Cloning, Molecular; COS Cells; DNA, Complementary; Gene Expression Regulation; Humans; Immunosuppressive Agents; Ionophores; Jurkat Cells; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Sequence Data; Platelet Activation; RNA, Messenger; Sequence Alignment; T-Lymphocytes, Cytotoxic; Tacrolimus; Tetradecanoylphorbol Acetate; Up-Regulation

1997
Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Mar-15, Volume: 160, Issue:6

    Topics: Calcineurin; CD28 Antigens; CD3 Complex; Cells, Cultured; Cytokines; Flavonoids; Humans; Lymphocyte Activation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; RNA, Messenger; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1998
Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism.
    The Biochemical journal, 1997, Nov-01, Volume: 327 ( Pt 3)

    Topics: Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Calcium-Transporting ATPases; Cyclosporine; Diglycerides; Humans; In Vitro Techniques; Muscle, Skeletal; Phosphorylation; Rabbits; Sarcoplasmic Reticulum; Tacrolimus; Tetradecanoylphorbol Acetate; Uncoupling Agents

1997
A role of calcineurin in coreceptor regulation during differentiation of Cd4+Cd8+ T cells.
    Biochemical and biophysical research communications, 1998, Jun-18, Volume: 247, Issue:2

    Topics: Animals; Calcineurin; CD4 Antigens; CD8 Antigens; Cell Differentiation; Cell Line; Down-Regulation; Immunosuppressive Agents; Ionomycin; Ionophores; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; RNA, Messenger; Signal Transduction; T-Lymphocyte Subsets; Tacrolimus; Tetradecanoylphorbol Acetate; Transfection

1998
Lymphotactin: a key regulator of lymphocyte trafficking during acute graft rejection.
    Immunology, 1998, Volume: 95, Issue:1

    Topics: Acute Disease; Animals; Blotting, Northern; Cells, Cultured; Chemotaxis, Leukocyte; Cyclosporine; Gene Expression; Graft Rejection; Immunosuppressive Agents; In Situ Hybridization; Kidney Transplantation; Lymphocytes; Lymphokines; Male; Phytohemagglutinins; Rats; Rats, Inbred F344; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Tacrolimus; Tetradecanoylphorbol Acetate; Transplantation, Homologous

1998
Ca2+-ATPase inhibitor induces IL-4 and MCP-1 production in RBL-2H3 cells.
    Immunology letters, 1998, Volume: 64, Issue:1

    Topics: Animals; Antioxidants; Calcium-Transporting ATPases; Chemokine CCL2; Dactinomycin; Dose-Response Relationship, Drug; Hydroquinones; Indoles; Interleukin-4; Mast Cells; Rats; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
Distinctive calcineurin-dependent (FK506-sensitive) mechanisms regulate the production of the CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES vs IL-2 and TNF-alpha by activated human T cells.
    Cellular immunology, 1998, Dec-15, Volume: 190, Issue:2

    Topics: Calcineurin; Calcineurin Inhibitors; CD28 Antigens; CD3 Complex; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Cycloheximide; Cytokines; Dose-Response Relationship, Drug; Gene Expression; Humans; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Macrophage Inflammatory Proteins; Mitogens; Protein Synthesis Inhibitors; RNA, Messenger; T-Lymphocyte Subsets; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha

1998
Ex vivo assessment of immunosuppression in undiluted whole blood from pigs dosed with tacrolimus (FK506).
    Clinical immunology (Orlando, Fla.), 1999, Volume: 90, Issue:1

    Topics: Animals; Immunosuppressive Agents; Interleukin-2; Ionomycin; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocytes; Swine; Tacrolimus; Tetradecanoylphorbol Acetate

1999
Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506.
    Phytotherapy research : PTR, 1999, Volume: 13, Issue:6

    Topics: Cells, Cultured; Diterpenes; Epoxy Compounds; Humans; Immunosuppressive Agents; Interferon-gamma; Lymphocyte Activation; Medicine, Chinese Traditional; Phenanthrenes; Phytotherapy; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1999
Cyclosporin A inhibits Ca2+-mediated upregulation of the DNA repair enzyme DNA polymerase beta in human peripheral blood mononuclear cells.
    European journal of biochemistry, 1999, Volume: 264, Issue:3

    Topics: Animals; Base Sequence; Calcineurin; Calcium; Cyclosporine; DNA Polymerase beta; DNA Primers; DNA Repair; Humans; Immunosuppressive Agents; In Vitro Techniques; Ionomycin; Ionophores; Leukocytes, Mononuclear; Neoplasms; RNA, Messenger; Tacrolimus; Tetradecanoylphorbol Acetate; Up-Regulation

1999
Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors.
    Transplantation proceedings, 1999, Volume: 31, Issue:7

    Topics: Cells, Cultured; Cyclosporine; Enzyme Activation; Glomerular Mesangium; Humans; Kidney; Kinetics; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Tacrolimus; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Necrosis Factor-alpha

1999
Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation.
    The Biochemical journal, 1999, Dec-15, Volume: 344 Pt 3

    Topics: Actins; Cycloheximide; Dactinomycin; Gene Expression Regulation; Humans; Immunosuppressive Agents; Ionomycin; Protein Biosynthesis; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic

1999
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Dec-15, Volume: 163, Issue:12

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD28 Antigens; Cell Adhesion Molecules; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Fluid; Ionophores; Jurkat Cells; Lymphocyte Activation; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation

1999
NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells.
    Blood, 2000, Jul-15, Volume: 96, Issue:2

    Topics: Antigens; Binding Sites; Cell Separation; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Immunosuppressive Agents; Ionomycin; Luminescent Proteins; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Receptors, Antigen, T-Cell; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection

2000
The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:1

    Topics: Drug Interactions; Enzyme Inhibitors; Epithelial Sodium Channels; Immunophilins; Immunosuppressive Agents; Indoles; Maleimides; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Sirolimus; Sodium Channels; Tacrolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate

2000
Signal transduction pathways that contribute to increased protein synthesis during T-cell activation.
    Biochimica et biophysica acta, 2000, Nov-15, Volume: 1494, Issue:1-2

    Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Eukaryotic Initiation Factor-2B; Eukaryotic Initiation Factor-4E; Humans; Ionomycin; Kinetics; Lymphocyte Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin

2000
Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner.
    The Biochemical journal, 2000, Dec-15, Volume: 352 Pt 3

    Topics: Androstadienes; Bucladesine; Calcimycin; Calcineurin; Calcium; Calcium Signaling; Cyclosporine; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Humans; Kinetics; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Nuclear Proteins; Protein Kinase C; Proteins; RGS Proteins; RNA, Messenger; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin

2000
T cell activation signals upregulate CBP-dependent transcriptional activity.
    Biochemical and biophysical research communications, 2001, Mar-09, Volume: 281, Issue:4

    Topics: Antibodies, Monoclonal; Calcineurin; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; CREB-Binding Protein; DNA, Recombinant; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Ionomycin; Ionophores; Jurkat Cells; Luciferases; Nuclear Proteins; Plasmids; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transfection; Up-Regulation

2001
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
    Blood, 2001, Apr-15, Volume: 97, Issue:8

    Topics: Calcineurin; Calcineurin Inhibitors; Calcium Signaling; Capsid; Cells, Cultured; Cyclosporine; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Herpesvirus 8, Human; Humans; Indoles; Ionomycin; Maleimides; Microscopy, Electron; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; Virus Activation

2001
Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat-driven transcription and a possible implication of SHP-1.
    Blood, 2001, Apr-15, Volume: 97, Issue:8

    Topics: Active Transport, Cell Nucleus; Adult; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; HIV Long Terminal Repeat; HIV-1; Humans; Immunosuppressive Agents; Interleukin-1; Interleukin-2; Intracellular Signaling Peptides and Proteins; Ionomycin; Jurkat Cells; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; Organometallic Compounds; Phytohemagglutinins; Promoter Regions, Genetic; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; Recombinant Proteins; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; ZAP-70 Protein-Tyrosine Kinase

2001
Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro.
    Journal of immunological methods, 2001, Jul-01, Volume: 253, Issue:1-2

    Topics: Aniline Compounds; Animals; Blood; Calcium; CD28 Antigens; Concanavalin A; Crotonates; Cyclosporine; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Ionomycin; Kinetics; Lymphocyte Activation; Male; Mitogens; Nitriles; Rats; Rats, Inbred Lew; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Toluidines

2001
Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8(-) and CD8(+) peripheral blood T cells.
    Therapeutic drug monitoring, 2001, Volume: 23, Issue:4

    Topics: Adult; CD8 Antigens; CD8-Positive T-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Middle Aged; Monitoring, Immunologic; Organ Transplantation; Tacrolimus; Tetradecanoylphorbol Acetate

2001
The ascomycin macrolactam pimecrolimus (Elidel, SDZ ASM 981) is a potent inhibitor of mediator release from human dermal mast cells and peripheral blood basophils.
    The Journal of allergy and clinical immunology, 2001, Volume: 108, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Basophils; Calcimycin; Dose-Response Relationship, Drug; Histamine Release; Humans; Hypersensitivity; Immunoglobulin E; Inflammation Mediators; Mast Cells; Skin; Tacrolimus; Tetradecanoylphorbol Acetate

2001
Inhibition of cytokine production and cytokine-stimulated T-cell activation by FK506 (tacrolimus)1.
    Cell transplantation, 2001, Volume: 10, Issue:7

    Topics: Carcinogens; Cell Division; Gene Expression; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-7; Phytohemagglutinins; Recombinant Proteins; RNA, Messenger; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

2001
Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.
    The Journal of investigative dermatology, 2002, Volume: 118, Issue:5

    Topics: Biological Transport; Calcineurin; Calcineurin Inhibitors; Carcinogens; Cell Differentiation; Cell Membrane; Cell Nucleus; Cells, Cultured; Cyclophilin A; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Fibroblasts; Humans; Immunosuppressive Agents; Ionomycin; Ionophores; Keratinocytes; NFATC Transcription Factors; Nuclear Proteins; Psoriasis; Signal Transduction; Skin; Tacrolimus; Tacrolimus Binding Protein 1A; Tetradecanoylphorbol Acetate; Transcription Factors

2002
A tactic for screening inhibitors of interleukin-2 production.
    Analytical biochemistry, 2002, Jun-01, Volume: 305, Issue:1

    Topics: Animals; Cell Survival; Cyclosporine; Dose-Response Relationship, Drug; Formazans; Interleukin-2; Mice; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thymoma; Time Factors; Tumor Cells, Cultured

2002
Mycophenolic acid is a potent inhibitor of the expression of tumour necrosis factor- and tumour necrosis factor-receptor superfamily costimulatory molecules.
    Immunology, 2003, Volume: 109, Issue:1

    Topics: Antigens, CD; CD27 Ligand; CD40 Ligand; Cells, Cultured; Dendritic Cells; Humans; Immunosuppressive Agents; Ionomycin; Lymph Nodes; Lymphocyte Activation; Membrane Proteins; Mycophenolic Acid; Receptors, Nerve Growth Factor; Receptors, OX40; Receptors, Tumor Necrosis Factor; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7; Tumor Necrosis Factor Receptor Superfamily, Member 9; Tumor Necrosis Factor-alpha

2003
Two distinct calcium-sensitive and -insensitive PKC up- and down-regulate an alpha-bungarotoxin-resistant nAChR1 in insect neurosecretory cells (DUM neurons).
    The European journal of neuroscience, 2003, Volume: 17, Issue:10

    Topics: Animals; Bungarotoxins; Calcium; Carcinogens; Diglycerides; Down-Regulation; Enzyme Activation; Immunosuppressive Agents; Male; Membrane Potentials; Neurons; Neurosecretory Systems; Periplaneta; Protein Kinase C; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Up-Regulation

2003
Calcium signaling pathway involving calcineurin regulates interleukin-8 gene expression through activation of NF-kappaB in human osteoblast-like cells.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2004, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Calcimycin; Calcineurin; Calcium Signaling; Cell Line; Cyclosporine; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interleukin-8; Ionophores; NF-kappa B; Osteoblasts; Promoter Regions, Genetic; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2004
Exposure to 4-tert-octylphenol, an environmentally persistent alkylphenol, enhances interleukin-4 production in T cells via NF-AT activation.
    Toxicology and applied pharmacology, 2004, May-15, Volume: 197, Issue:1

    Topics: Animals; Calcineurin Inhibitors; Environmental Pollutants; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Hemocyanins; Hypersensitivity; Immunoglobulin E; Immunosuppressive Agents; Interleukin-4; Luciferases; Lymph Nodes; Mice; Mice, Inbred BALB C; NF-kappa B; Phenols; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transfection

2004
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
    Circulation research, 2004, Oct-01, Volume: 95, Issue:7

    Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate

2004
Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.
    The Journal of biological chemistry, 2005, Feb-18, Volume: 280, Issue:7

    Topics: Animals; Binding Sites; Calcineurin; Calcium; Cardiomegaly; Cells, Cultured; Cricetinae; Dogs; Female; Heart; Humans; Ion Transport; Male; Mutation; Myocytes, Cardiac; Phenylephrine; Protein Binding; Rats; Sodium; Sodium-Calcium Exchanger; Tacrolimus; Tetradecanoylphorbol Acetate

2005
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
    British journal of pharmacology, 2005, Volume: 145, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; I-kappa B Kinase; Indoles; Keratinocytes; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, PAR-2; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases

2005
A cytokine promoter/yellow fluorescent protein reporter transgene serves as an early activation marker of lymphocyte subsets.
    Cellular immunology, 2005, Volume: 237, Issue:2

    Topics: Animals; Antigens; Bacterial Proteins; Base Sequence; Biomarkers; Cyclosporine; DNA, Recombinant; Gene Expression; Genes, Reporter; In Vitro Techniques; Interleukin-4; Ionomycin; Luminescent Proteins; Lymphocyte Activation; Lymphocyte Subsets; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin; Peptide Fragments; Promoter Regions, Genetic; Recombinant Fusion Proteins; Tacrolimus; Tetradecanoylphorbol Acetate

2005
Calcium-dependent expression of TNF-alpha in neural cells is mediated by the calcineurin/NFAT pathway.
    Molecular and cellular neurosciences, 2006, Volume: 31, Issue:4

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcineurin; Calcium; Calcium Channel Agonists; Calcium Signaling; Cycloheximide; Cyclosporine; Enzyme Inhibitors; Gene Expression Regulation; Humans; Immunosuppressive Agents; Ionophores; Neurons; NFATC Transcription Factors; Oligopeptides; PC12 Cells; Protein Synthesis Inhibitors; Rats; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha

2006
Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humans.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:1

    Topics: Adult; Antigens, CD; Biomarkers; CD4-Positive T-Lymphocytes; Cell Proliferation; Concanavalin A; Cyclosporine; Drug Monitoring; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Methylprednisolone; Middle Aged; Mycophenolic Acid; Receptors, Transferrin; Reproducibility of Results; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2007
Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:6

    Topics: Cell Division; Cell Survival; Cholesterol; Concanavalin A; Cytokines; Enzyme Inhibitors; Humans; Immunologic Factors; Immunosuppressive Agents; Indoles; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Maleimides; Phytosterols; Protein Kinase C; Sitosterols; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

2008
Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects.
    Transplant immunology, 2009, Volume: 22, Issue:1-2

    Topics: Animals; Brefeldin A; Cell Line, Tumor; Gene Expression; Glucose; Golgi Apparatus; Guanine Nucleotide Exchange Factors; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Mice; Phytohemagglutinins; Proteins; Secretory Pathway; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

2009
Calcineurin activation by slow calcium release from intracellular stores suppresses protein kinase C regulation of L-type calcium channels in L6 cells.
    Cell calcium, 2009, Volume: 46, Issue:4

    Topics: Animals; Calcineurin; Calcium; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cell Line; Cyclosporine; Enzyme Inhibitors; Ion Channel Gating; Ion Transport; Myoblasts, Skeletal; Phorbol Esters; Protein Kinase C; Rats; Sarcoplasmic Reticulum; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin

2009
The calcineurin inhibitor, FK506, does not alter glutamate transport in the ischaemic mouse retina.
    Experimental eye research, 2010, Volume: 91, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Biological Transport; Calcineurin Inhibitors; Female; Glutamic Acid; Immunohistochemistry; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Reperfusion Injury; Retinal Diseases; Tacrolimus; Tetradecanoylphorbol Acetate

2010
Regulatory mechanisms of acetylcholine synthesis and release by T cells.
    Life sciences, 2012, Nov-27, Volume: 91, Issue:21-22

    Topics: Acetylcholine; Bucladesine; Cell Line; Choline O-Acetyltransferase; Gene Expression Regulation, Enzymologic; Humans; Immunosuppressive Agents; Phytohemagglutinins; RNA, Messenger; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

2012
Nuclear translocation of nuclear factor of activated T cells (NFAT) as a quantitative pharmacodynamic parameter for tacrolimus.
    Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2013, Volume: 83, Issue:12

    Topics: Calcium Ionophores; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Nucleus; Flow Cytometry; Graft Rejection; Humans; Immunosuppressive Agents; Interferon-gamma; Ionomycin; Jurkat Cells; Kidney Transplantation; NFATC Transcription Factors; Protein Transport; Reproducibility of Results; Tacrolimus; Tetradecanoylphorbol Acetate

2013