tetradecanoylphorbol acetate has been researched along with sphingosine in 287 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (18.12) | 18.7374 |
| 1990's | 183 (63.76) | 18.2507 |
| 2000's | 42 (14.63) | 29.6817 |
| 2010's | 10 (3.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Rodríguez Del Castillo, A; Trifaró, JM; Vitale, ML | 1 |
| Chase, HS; Lindeman, RP; Luo, H | 1 |
| Bussières, L; Dechaux, M; Laborde, K; Sachs, C; Shahedi, M | 1 |
| Alpern, RJ; Cano, A; Horie, S; Miller, RT; Moe, O; Yamaji, Y | 1 |
| Franson, RC; Lattanzio, KS; Rosenthal, MD | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Engler, D; Funder, JW; Liu, JP; Robinson, PJ | 1 |
| Berry, SA; Gudelsky, GA | 1 |
| Fröhlich, O; Wallert, MA | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Park, HY; Sampson, PH; Scheidl, H; Scita, G; Wolf, G | 1 |
| Chao, R; Hannun, YA; Khan, W | 1 |
| Bennett, MV; Durand, GM; Gregor, P; Uhl, GR; Zheng, X; Zukin, RS | 1 |
| Pradines-Figueres, A; Raetz, CR | 1 |
| Deli, E; Kiss, Z | 2 |
| Keynan, A; Sandler, N | 1 |
| Barnett, T; Birt, DF; Enkvetchakul, B; Geisler, V; Liotta, DC; Menaldino, D; Merrill, AH | 1 |
| Anderson, WB; Crilly, KS; Kiss, Z; Rossi, MA | 1 |
| Joyce, NC; Meklir, B | 1 |
| Chakraborti, S; Michael, JR; Sanyal, T | 1 |
| Bierman, EL; Mendez, AJ; Oram, JF | 1 |
| Evans, CH; Georgescu, HI; Hulkower, KI | 1 |
| Berk, BC; de Roux, N; Pouysségur, J; Rao, GN; Sardet, C | 1 |
| Basbaum, CB; Cherqui, G; Hermelin, B; Mergey, M; Paul, A; Picard, J; Veissière, D | 1 |
| Chedrese, PJ; Ly, H; Murphy, BD; Rajkumar, K | 1 |
| MacGlashan, DW; Warner, JA | 1 |
| Grosman, N | 1 |
| Ganz, MB; Vignery, A; Wang, F | 1 |
| Hakomori, S; Handa, K; Igarashi, Y; Nisar, M | 1 |
| Kojima, I; Shibata, H | 1 |
| Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P | 1 |
| Huang, CL; Ives, HE; Weiss, RH | 1 |
| Levine, JD; White, DM | 1 |
| Endou, H; Jung, KY; Ota, R; Tojo, A | 1 |
| Baldwin, TJ; Leach, KL; Norris, V; Sweeney, ST; Williams, PH | 1 |
| Apgar, JR | 1 |
| Aunis, D; Bader, MF; Henry, JP; Pradel, LA; Sarafian, T | 1 |
| Ballou, LR; Barker, SC; Candela, M | 1 |
| Celada, A; Maki, RA | 1 |
| Elstad, MR; McIntyre, TM; Prescott, SM; Zimmerman, GA | 1 |
| Fain, JN; Lee, HM | 1 |
| Raymond, JR | 1 |
| Inokuchi, J; Jimbo, M; Kumamoto, Y; Nagamatsu, A; Shimeno, H | 1 |
| Harrison, BC; Mobley, PL; Staskavage, DL | 1 |
| Garcia, MC; Mueller, HW; Rosenthal, MD | 1 |
| Desai, NN; Spiegel, S | 1 |
| Suen, CS; Wilk, S | 1 |
| Borek, C; Merrill, AH; Ong, A; Stevens, VL; Wang, E | 1 |
| Campenot, RB; Draker, DD; Walji, AH | 1 |
| Martin, DB; Pek, SB; Thomas, TP | 1 |
| Chattopadhyay, J; Crilly, K; Kiss, Z | 1 |
| Dressler, KA; Kan, CC; Kolesnick, RN | 1 |
| Bement, WM; Capco, DG | 1 |
| Kitaoka, M; Kojima, I; Ogata, E | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Katayama, Y; Miyazaki, S; Swann, K | 1 |
| Bellomo, G; McConkey, DJ; Mirabelli, F; Orrenius, S; Perotti, M; Toddei, F; Vairetti, M | 1 |
| Kinkade, JM; Merrill, AH; Owens, NE; Stevens, VL; Winton, EF | 1 |
| Dufau, ML; Fabbri, A; Tinajero, JC; Ulisse, S | 1 |
| Caulfield, T; Fiore, S; Kataoka, H; Nicolaou, KC; Serhan, CN | 1 |
| Huang, CL; Ives, HE; Lowe, JH | 1 |
| Goodman, HM; Gorin, E; Honeyman, TW; Tai, LR | 1 |
| Endou, H; Satoh, T | 1 |
| Fisher, TE; Kaczmarek, LK | 1 |
| Cox, LR; Murphy, SK; Ramos, K | 1 |
| Delbart, C; Devred, D; Fruchart, JC; Martin-Nizard, F; Nazih, H | 1 |
| Adu, J; Burgoyne, RD; Cambray-Deakin, MA | 1 |
| Gat-Yablonski, G; Sagi-Eisenberg, R | 1 |
| Desai, NN; Murphey, JM; Spiegel, S; Zhang, H | 1 |
| Buckley, NE; Gibson, K; Spiegel, S; Zhang, H | 1 |
| Ikebuchi, H; Saito, Y; Suzuki, K; Suzuki, S; Terao, T | 1 |
| Hill, ME; Murray, DK; Nelson, DH | 1 |
| August, J; Bishop, WR; Pai, JK; Petrin, JM | 1 |
| Baines, AD; Ho, P | 1 |
| Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R | 1 |
| Ferguson, JE; Nuccitelli, R; Takeichi, M; Winkel, GK | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y | 1 |
| Igusa, Y; Miyazaki, S; Swann, K | 1 |
| Kolesnick, RN | 1 |
| Gillies, RJ; Hoyer, PB; Martinez, R; Sneider, JM | 1 |
| Gillies, RJ; Martinez, R | 1 |
| Eaton, DC; Ling, BN | 1 |
| Bedoy, CA; Mobley, PL | 1 |
| Chen, MS; Hwang, JL; Hwong, CL | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Jacobson, D; O'Flaherty, JT | 1 |
| Beattie, LL; Cragoe, EJ; Gerrard, JM; Israels, SJ; Lint, D; McNicol, A; Park, J | 1 |
| Bixby, JL | 1 |
| Boner, G; Gbarah, A; Mhashilkar, AM; Sharon, N | 1 |
| Aizu, E; Kato, R; Nakadate, T; Nishikawa, K; Yamamoto, S | 1 |
| DiGirolamo, M; Lambeth, JD; Merrill, AH; Robertson, DG | 1 |
| De Meyts, P; Smal, J | 1 |
| Capeau, J; Caron, M; Cherqui, G; Picard, J; Wicek, D | 1 |
| Aunis, D; Bader, MF; Sontag, JM; Thiersé, D | 1 |
| Hsu, T; Simpson, RU; Taylor, JM; Wendt, MD | 1 |
| McIntyre, TM; Nelson, P; Parker, CJ; Prescott, SM; Stevens, DL; Whatley, RE; Zimmerman, GA | 1 |
| Kaever, V; Pfannkuche, HJ; Resch, K; Wessel, K | 1 |
| Kinkade, JM; Merrill, AH; Owens, NE; Smith, EE; Stevens, VL; Winton, EF | 1 |
| Benveniste, J; Bessou, G; Bossant, MJ; Joly, F; Leyravaud, S; Ninio, E | 1 |
| Bell, RM; Hannun, YA; Hunter, R; Lambeth, JD; Loomis, C; Menaldino, D; Merrill, AH; Nimkar, S; Stevens, VL; Tyagi, SR | 1 |
| Gelfand, EW; Hill, M; May, C; Mills, GB | 1 |
| McIntyre, TM; Prescott, SM; Reinhold, SL; Zimmerman, GA | 1 |
| Arnold, RR; Kinkade, JM; Lambeth, JD; Merrill, AH; Rice, WG; Wilson, E | 1 |
| Dougherty, RW; Niedel, JE; Rider, LG | 1 |
| Burnham, DN; Lambeth, JD; Tamura, M; Tyagi, SR | 1 |
| Murphy, CF; Orozco, E; Ravdin, JI; Weikel, CS | 1 |
| Canonico, PL; Catania, MV; Favit, A; Nicoletti, F | 1 |
| Johnson, PC; Saitoh, M; Salzman, EW; Smith, M; Ware, JA | 1 |
| Birt, DF; Enkvetchakul, B; Merrill, AH | 1 |
| Neet, KE; Reinhold, DS | 1 |
| Conn, PJ; Kaczmarek, LK; Strong, JA | 1 |
| Bell, RM; Lambeth, JD; Merrill, AH; Olcott, MC; Wilson, E | 1 |
| Cheng, YC; Grill, SP; Li, JS; Nutter, LM; Tan, RS | 1 |
| Selmanoff, M; Shu, C | 1 |
| Lambeth, JD; Liotta, DC; Merrill, AH; Mullins, RE; Uhlinger, DJ; Wang, E; Wilson, E | 1 |
| Bloom, BR; Fan, XD; Goldberg, M | 1 |
| Gershengorn, MC; Winicov, I | 1 |
| Fernyhough, P; Hall, FL; Ishii, DN; Vulliet, PR | 1 |
| Bell, RM; Davis, RJ; Faucher, M; Gironès, N; Hannun, YA | 1 |
| Burgoyne, RD; Morgan, A; O'Sullivan, AJ | 1 |
| Elder, JT; Fisher, GJ; Gupta, AK; Nickoloff, BJ; Voorhees, JJ | 1 |
| Carpenter, G; Wahl, M | 1 |
| Lichtman, MA; Packman, CH; Phatak, PD | 1 |
| Civan, MM; O'Brien, TG; Peterson-Yantorno, K | 1 |
| Grove, DS; Mastro, AM | 1 |
| Cook, JS; Dawson, WD | 1 |
| Bell, RM; Hannun, YA; Kinkade, JM; Merrill, AH; Sereni, AM; Stevens, VL | 1 |
| Murray, DK; Nelson, DH | 1 |
| Artini, M; Avantaggiati, ML; Balsano, C; Chirillo, P; Costanzo, A; Levrero, M; Natoli, G | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| Bird, TA; Gayle, M; Kyriakis, JM; Milne, A; Tyshler, L; Virca, GD | 1 |
| Bartschat, DK; Rhodes, TE | 1 |
| Kitano, I; Matsunaga, T; Mori, N; Nario, K | 1 |
| He, H; Herington, AC; Roupas, P | 1 |
| Kaila, K; Pasternack, M; Törnquist, K | 1 |
| Berger, A; Rosenthal, D; Spiegel, S | 1 |
| de Souza, W; Martiny, A; Meyer-Fernandes, JR; Vannier-Santos, MA | 1 |
| Bongrand, P; Bouhamdan, M; Capo, C; Huang, CK; Mege, JL; Sanguedolce, MV | 1 |
| Bellido, L; López-González, MA; Lucas, M; Pedrera, C | 1 |
| Olsen, CL; Raymond, JR | 1 |
| Baudet, C; Brachet, P; Galve-Roperh, I; Laviada, ID; Naveilhan, P | 1 |
| Breu, J; Eldar, H; Livneh, E; Slack, BE; Wurtman, RJ | 1 |
| Hakomori, S; Igarashi, Y; Masamune, A; Ohta, H; Sweeney, EA; Yatomi, Y | 1 |
| Maneckjee, R; Minna, JD | 1 |
| Fischer, I; Friedman, E; Levitt, P; Qian, J; Wang, HY | 1 |
| Knöfler, R; Takada, A; Takada, Y; Urano, T | 1 |
| Baumgold, J; Curran, P; Fishman, PH; Zhou, XM | 1 |
| Anderson, WB; Kiss, Z; Tomono, M | 1 |
| Hamamura, I; Isohama, Y; Kai, H; Miyata, T; Takahama, K; Yoshitake, K | 1 |
| Hansen, HS; Lauritzen, L; Nielsen, LL; Vinggaard, AM | 1 |
| Anderson, WH; Kiss, Z | 2 |
| Hundle, B; Messing, RO; Roivainen, R | 1 |
| Larivée, P; Levine, SJ; Logun, C; Martinez, A; Shelhamer, JH; Wu, T | 1 |
| Garcia, JG; Jayaram, HN; Natarajan, V; Scribner, WM | 1 |
| Cordier, J; Glowinski, J; Murphy, NP; Prémont, J | 1 |
| Andersen, CB; Hansen, AB | 1 |
| Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB | 1 |
| Brooker, G; Mattie, M; Spiegel, S | 1 |
| Kiss, Z | 2 |
| Ishihara, H; Nagaki, M; Sasaki, H; Shimura, S; Takishima, T | 1 |
| Alexandrova, AY; Bershadsky, AD; Dugina, VB; Paterson, H; Vasiliev, JM | 1 |
| Hara, A; Taketomi, T; Uemura, K | 1 |
| Campbell, XZ; Fields, AP; Neet, KE; Singh, KR; Taylor, LK | 1 |
| Arruda, JA; Pahlavan, P; Sack, E; Wang, LJ | 1 |
| Hakomori, S; Igarashi, Y; Mazurek, N; Megidish, T | 1 |
| Borek, C; Merrill, AH | 1 |
| Cunningham, GR; House, FS; Stewart, SJ | 1 |
| Kwan-Yeung, L; Wong, K | 1 |
| Fantus, IG; Nower, P; Schwartz, T; Torossian, K | 1 |
| Rossignol, B; Sergheraert, C; Zoukhri, D | 1 |
| Davis, BB; Thomas, DJ; Zenser, TV | 1 |
| Clarke, BL; Fitzpatrick, LA; Hassager, C | 1 |
| Crow, T; Forrester, J | 1 |
| Chung, CH; Ha, DB; Jeon, YJ; Kim, HS; Lee, IH | 1 |
| Gould-Fogerite, S; Mannino, RJ; Reston, JT | 1 |
| Cao, YZ; Eskew, ML; Hildenbrandt, G; Mastro, AM; Reddy, CC; Reddy, PV | 1 |
| Hakomori, S; Igarashi, Y; Megidish, T; Ruan, F; Toyokuni, T; Yatomi, Y | 1 |
| Campbell, XZ; Neet, KE | 1 |
| Babenko, NA; Kavok, NS | 1 |
| Hakomori, S; Igarashi, Y; Masamune, A; Ohta, H; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| Hakomori, S; Igarashi, Y; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| McKay, C; Miller, A | 1 |
| Chang, HC; Lee, SC; Yang, SD | 1 |
| Bridgham, JT; Johnson, AL; Witty, JP | 1 |
| Chao, TY; Shaio, MF; Su, MH; Wang, CL; Yang, KD | 1 |
| Babenko, NA; Krasil'nikova, OA | 1 |
| Igarashi, Y; Kennedy, SD; Kickler, TS | 1 |
| Buckley, NE; Goodemote, KA; Olivera, A; Spiegel, S; Su, Y; Wang, F | 1 |
| Ducibella, T; LeFevre, L | 1 |
| Farooq, M; Larocca, JN; Norton, WT | 1 |
| Fujioka, T; Im, DS; Katada, T; Kondo, Y; Okajima, F; Ui, M | 1 |
| Hall, A; Nobes, CD; Spiegel, S; Wang, F | 1 |
| Hori, Y; Shinkai, M; Takeyama, Y; Ueda, T; Yamamoto, M | 1 |
| Chow, SC; Orrenius, S; Pörn-Ares, MI; Slotte, JP | 1 |
| Hrelia, S; Orlati, S; Rugolo, M | 1 |
| Conway, AM; Pyne, NJ; Pyne, S; Tolan, D | 1 |
| Goode, N; Keenan, C; Pears, C | 2 |
| Olivera, A; Rani, CS; Romanowski, A; Spiegel, S | 1 |
| Anderson, WH; Crilly, KS; Kiss, Z | 1 |
| Igarashi, Y; Okajima, F; Sato, K; Tomura, H; Ui, M | 1 |
| Inaba, K; Ishikawa, H; Kashima, K; Matsumoto, M; Mitsuyoshi, H; Nakajima, Y; Nakashima, T; Okanoue, T; Sakamoto, Y | 1 |
| Banasiak, M; Barańska, J; Czarny, M; Stepkowski, D; Wiktorek-Wójcik, M | 1 |
| Cuvillier, O; Rosenthal, DS; Smulson, ME; Spiegel, S | 1 |
| Conway, AM; Pyne, NJ; Pyne, S | 1 |
| Kuan, CY; Lee, SC; Wen, ZD; Yang, SD | 1 |
| Kimura, M; Ogihara, M | 3 |
| Cuvillier, O; Kleuser, B; Spiegel, S | 1 |
| Berg, KA; Kaga, S; Ochi, A; Ragg, SJ | 1 |
| Delgado, F; Diaz, P; López-González, MA; Lucas, M | 1 |
| Kozawa, O; Matsuno, H; Tokuda, H; Uematsu, T | 1 |
| Barrett, GL; Ping, SE | 1 |
| Abd-Elfattah, AS; Sholley, MM; Taher, MM | 1 |
| Chang, HC; Chuang, LY; Hung, WC | 1 |
| Baltz, JM; Bavister, BD; Lane, M | 1 |
| Akaike, T; Watanabe, Y | 1 |
| Björklund, S; Ekokoski, E; Nikmo, A; Törnquist, K; Vainio, M | 1 |
| Bobak, DA; Bruni, P; Meacci, E; Moorman, JP; Moss, J; Vasta, V; Vaughan, M | 1 |
| Kozawa, O; Shinoda, J; Tokuda, H; Uematsu, T | 1 |
| Barańska, J; Czajkowski, R | 1 |
| Baumruker, T; Csonga, R; Kikuchi, GE; Novotny, V; Prieschl, EE | 1 |
| Alexandrov, I; Kisselev, L; McLennan, A; Prudowski, I; Vartanian, A | 1 |
| Barańska, J; Bobeszko, M; Dygas, A; Sidorko, M | 1 |
| Banno, Y; Fujita, H; Ito, Y; Kuzumaki, N; Nakashima, S; Nozawa, Y; Ono, Y | 1 |
| Conover, CA; Dolezalova, H; Goetzl, EJ; Hu, YL; Jaffe, RB; Kalli, KR; Kong, Y | 1 |
| Dash, PK; Hayes, RL; Kampfl, AW; Moore, AN; Zhao, X | 1 |
| Barros, FS; Dutra, PM; Lopes, AH; Meyer-Fernandes, JR; Rodrigues, CO; Souto-Padrón, T | 1 |
| Hong, CY; Yang, SH | 1 |
| Ishikawa, K; Okajima, F; Sato, K; Ui, M | 1 |
| Chan, C; Goldkorn, T | 1 |
| Bruni, P; Cencetti, F; Donati, C; Farnararo, M; Meacci, E; Romiti, E | 1 |
| Arima, K; Fujisawa, K; Miyakawa, I; Narahara, H; Nasu, K; Sugano, T | 1 |
| Barańska, J; Bobeszko, M; Dygas, A; Nalepa, I | 1 |
| Bruni, P; Cencetti, F; Donati, C; Meacci, E; Romiti, E | 1 |
| Kobayashi, S; Kumagai, M; Makioka, A; Ohtomo, H; Takeuchi, T | 1 |
| Cheng, S; Mao, J; Rehder, V | 1 |
| Honda, S; Kohsaka, S; Kurihara, T; Nakajima, K; Tohyama, Y | 1 |
| Ahmed, IS; Alderton, F; Darroch, P; McKie, A; Pyne, N; Pyne, S; Sambi, B | 1 |
| Dutra, PM; Lopes, AH; Pereira, AF; Rosa , MS; Vieira, RB | 1 |
| Kabarowski, JH; Le, LQ; Witte, ON; Xu, Y; Zhu, K | 1 |
| Cuvillier, O; Levade, T | 1 |
| Baldini, G; Borgatti, P; Bortul, R; Capitani, S; Martelli, AM; Neri, LM; Tabellini, G | 1 |
| Garcha, K; Steele, JE; Sun, D | 1 |
| Becker, KP; Facchinetti, MM; Hannun, YA; Johnson, KR; Obeid, LM | 1 |
| Kaczmarek, LK; Magoski, NS; Zhang, Y | 1 |
| Ciereszko, RE; Dusza, L; Kaminska, B; Opalka, M | 1 |
| Bryceson, Y; Damaj, B; Gessani, S; Jin, Y; Knudsen, E; Maghazachi, AA; Wang, L | 1 |
| Choe, Y; Jung, H; Khang, I; Kim, K | 1 |
| Domae, N; Kambara, M; Kawai, S; Sawai, H; Yakushiji, K | 1 |
| Hunsperger, EA; Wilcox, CL | 1 |
| Laychock, SG; Sessanna, SM; Tian, Y | 1 |
| Fukuda, J; Kawano, Y; Miyakawa, I; Narahara, H; Nasu, K; Zeineh, K | 1 |
| Bae, S; Cho, CK; Choi, JA; Chung, HY; Kang, CM; Kang, S; Kim, MJ; Lee, SJ; Lee, YS; Park, MT; Um, HD | 1 |
| Barańska, J; Bobeszko, M; Dygas, A; Krzemiński, P; Pomorski, P | 1 |
| Hisano, N; Igarashi, Y; Nakahara, K; Ozaki, Y; Yamamura, S; Yatomi, Y | 1 |
| Endo, H; Hanzawa, A; Kanegae, H; Matsumoto, K; Miyazawa, K; Nakabayashi, Y; Shinoda, H; Suda, Y; Suetsugu, M; Takano, A; Takeshita, A; Tanaka, S; Ueyama, Y; Yasui, T | 1 |
| Watsky, MA; Yin, F | 1 |
| Abbey-Hosch, SE; Potter, LR; Smirnov, D | 1 |
| Baumruker, T; Billich, A; Bornancin, F; Huesken, D; Mechtcheriakova, D; Natt, F | 1 |
| Ali, A; Sirard, MA | 1 |
| Bagley, CJ; Hewitt, NM; Moretti, PA; Pitson, SM; Sutherland, CM; Vadas, MA | 1 |
| Ancellin, N; Fernandez, SM; Hla, T; Sha'afi, RI; Thompson, B | 1 |
| Choi, CH; Igarashi, Y; Jin, YX; Kihara, A; Lee, YM; Moon, DC; Oh, S; Yoo, HS | 1 |
| Back, SJ; Kim, CD; Kwon, YB; Lee, JH; Lee, YS; Park, JK; Piao, YJ; Seo, YJ; Sohn, KC; Suhr, KB | 1 |
| Santos, AL; Soares, RM | 1 |
| Kawakami, A; Kondo, K; Nagai, M; Shimokado, K; Tani, M; Yoshida, M | 1 |
| Igarashi, Y; Jin, YX; Kihara, A; Lee, YM; Shi, LH; So, HY; Yim, YH; Yoo, HS | 1 |
| Anelli, V; Grabowski, GA; Hannun, YA; Jenkins, RW; Kitatani, K; Obeid, LM; Rajagopalan, V; Sheldon, K; Sun, Y | 1 |
| Furuchi, T; Homma, H; Katane, M; Sekine, M; Suzuki, T | 1 |
| Allegood, J; Hait, NC; Harikumar, KB; Kordula, T; Luo, C; Maceyka, M; Marmorstein, R; Milstien, S; Singh, SK; Spiegel, S; Strub, GM | 1 |
| Kanazawa, T; Kozutsumi, Y; Naito, Y; Okano, M; Takematsu, H; Yamamoto, H | 1 |
| Huang, JA; Jiang, HX; Liu, SQ; Qin, MB; Tang, GD; Zhong, YY | 1 |
| Abdel-Samie, SA; Al Qalam, AM; Anelli, V; El-Shewy, HM; Jaffa, AA; Kitatani, K; Lee, MH; Luttrell, LM; Obeid, LM | 1 |
| Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT | 1 |
| Huang, JA; Liu, SQ; Qin, MB; Su, YJ; Tang, GD | 1 |
| Jung, YG; Kim, BH; Kim, S; Kim, TY; Lee, JM | 1 |
| Du, Y; Jiang, R; Shi, Y; Yu, W; Zeng, C; Zhang, A | 1 |
| Hankemeier, T; Ramakers, C; van Duinen, V; van Zonneveld, AJ; Vulto, P; Zhu, D | 1 |
| García-Sáinz, JA; Martínez-Morales, JC; Reyes-Cruz, G; Romero-Ávila, MT | 1 |
| Bocci, F; Jolly, MK; Kang, TY; Levchenko, A; Levine, H; Onuchic, JN | 1 |
1 review(s) available for tetradecanoylphorbol acetate and sphingosine
| Article | Year |
|---|---|
The regulation of excitability by second messengers and protein kinases in peptidergic neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Aplysia; Calcium; Calcium Channels; Enzyme Activation; Ion Channel Gating; Isoquinolines; Neurons; Neuropeptides; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinases; Protein Processing, Post-Translational; Second Messenger Systems; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
286 other study(ies) available for tetradecanoylphorbol acetate and sphingosine
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Protein kinase C activation by phorbol esters induces chromaffin cell cortical filamentous actin disassembly and increases the initial rate of exocytosis in response to nicotinic receptor stimulation.
Topics: Actins; Adrenal Medulla; Alkaloids; Animals; Calcium; Cattle; Enzyme Activation; Exocytosis; Kinetics; Macromolecular Substances; Microscopy, Fluorescence; Naphthalenes; Nicotine; Norepinephrine; Polycyclic Compounds; Protein Kinase C; Receptors, Nicotinic; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Participation of protein kinase C in desensitization to bradykinin and to carbachol in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Calcium; Carbachol; Cell Line; Cell Membrane; Dogs; Epithelium; Isoquinolines; Kidney; Kinetics; Microscopy, Fluorescence; Piperazines; Protein Kinase C; Receptors, Cell Surface; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C activation causes inhibition of Na/K-ATPase activity in Madin-Darby canine kidney epithelial (MDCK) cells.
Topics: Amiloride; Animals; Cell Line; Cycloheximide; Dactinomycin; Diglycerides; Diuretics; Dogs; Dopamine; Enzyme Activation; Furosemide; Kinetics; Protein Kinase C; Protein Synthesis Inhibitors; Sodium-Potassium-Exchanging ATPase; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity.
Topics: Animals; Carrier Proteins; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Genes, fos; Genes, jun; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Kinetics; Mice; Protein Kinase C; Proto-Oncogene Proteins c-jun; RNA, Messenger; Simian virus 40; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Transfection | 1992 |
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester.
Topics: Arachidonic Acid; Aristolochic Acids; Calcimycin; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Phosphatidate Phosphatase; Phospholipase D; Phospholipases A; Phospholipases A2; Polymers; Prostaglandins B; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Evidence that the stimulation by arginine vasopressin of the release of adrenocorticotropin from the ovine anterior pituitary involves the activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cells, Cultured; Corticotropin-Releasing Hormone; Enzyme Activation; Female; Isoquinolines; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Protein Kinase Inhibitors; Retinaldehyde; Sheep; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Evidence for protein kinase-C mediation of the neurotensin-induced activation of tyrosine hydroxylase in tuberoinfundibular dopaminergic neurons.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Bucladesine; Dihydroxyphenylalanine; Dopamine; Enzyme Activation; Hydrazines; Hypothalamus; In Vitro Techniques; Male; Median Eminence; Neurons; Neurotensin; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine 3-Monooxygenase | 1992 |
Alpha 1-adrenergic stimulation of Na-H exchange in cardiac myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Carrier Proteins; Hydrogen-Ion Concentration; Isoquinolines; Myocardium; Norepinephrine; Piperazines; Protein Kinase C; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
The effect of sphingosine and phorbol ester on the signal transduction enzymes and fibronectin release in cell culture.
Topics: Cell Line; Cyclic AMP; Enzyme Activation; Fibroblasts; Fibronectins; Humans; Isoquinolines; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Division; Cell Line; Ceramides; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Ionomycin; Isomerism; Isoquinolines; Molecular Weight; Naphthalenes; Okadaic Acid; Phosphorylation; Piperazines; Polycyclic Compounds; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Colforsin; Diterpenes; Enzyme Activation; Female; Genetic Variation; Kinetics; Ligands; Molecular Sequence Data; N-Methylaspartate; Oligodeoxyribonucleotides; Oocytes; Polyamines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, N-Methyl-D-Aspartate; RNA Splicing; Sphingosine; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Xenopus laevis | 1992 |
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Membrane-protein phosphorylation in the Bacillus subtilis cell cycle.
Topics: Bacillus subtilis; Bacterial Proteins; Cell Cycle; DNA Replication; DNA, Bacterial; Membrane Proteins; Phosphorylation; Sphingosine; Tetradecanoylphorbol Acetate; Vancomycin | 1992 |
Influences of sphingosine on two-stage skin tumorigenesis in Sencar mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Body Weight; Carcinoma; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Papilloma; Skin Neoplasms; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Selective inhibition by 4-hydroxynonenal of sphingosine-stimulated phospholipase D in NIH 3T3 cells.
Topics: 3T3 Cells; Aldehydes; Animals; Enzyme Activation; Hydrolysis; Mice; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C activation during corneal endothelial wound repair.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Movement; Cells, Cultured; Endothelium, Corneal; Enzyme Activation; Epidermal Growth Factor; Fluorescent Antibody Technique; Fluorescent Dyes; Isoquinolines; Male; Phalloidine; Piperazines; Protein Kinase C; Rabbits; Rhodamines; Sphingosine; Tetradecanoylphorbol Acetate; Wound Healing | 1992 |
Defining the role of protein kinase c in calcium-ionophore-(A23187)-mediated activation of phospholipase A2 in pulmonary endothelium.
Topics: Animals; Arachidonic Acid; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Phospholipases A; Phospholipases A2; Protein Kinase C; Pulmonary Artery; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol.
Topics: Apolipoprotein A-I; Apolipoproteins A; Biological Transport; Calcimycin; Carrier Proteins; Cell Membrane; Cells, Cultured; Cholesterol; Diglycerides; Down-Regulation; Enzyme Activation; Humans; Lipoproteins, HDL; Protein Kinase C; Receptors, Cell Surface; Receptors, Lipoprotein; RNA-Binding Proteins; Skin; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.
Topics: Alkaloids; Animals; Cartilage, Articular; Cells, Cultured; Dinoprostone; Enzyme Activation; Fibroblast Growth Factor 2; Gelatinases; Interleukin-1; Isoenzymes; Kinetics; Pepsin A; Phosphoproteins; Phosphorylation; Protein Kinase C; Rabbits; Recombinant Proteins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Na+/H+ antiporter gene expression during monocytic differentiation of HL60 cells.
Topics: Carrier Proteins; Cell Differentiation; Cycloheximide; Diglycerides; Gene Expression; Humans; In Vitro Techniques; Leukemia, Myeloid; Monocytes; RNA, Messenger; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Regulation of secretion in cultured tracheal serous cells by protein kinases A and C.
Topics: Animals; Calcimycin; Chondroitin Sulfate Proteoglycans; Cyclic AMP; Isoproterenol; Protein Kinase C; Protein Kinases; Serous Membrane; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1991 |
Protein kinase C, an endogenous regulator of hormone-induced cyclic AMP induction in porcine luteal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Colistin; Corpus Luteum; Cyclic AMP; Female; Isoquinolines; Luteinizing Hormone; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Signal transduction events in human basophils. A comparative study of the role of protein kinase C in basophils activated by anti-IgE antibody and formyl-methionyl-leucyl-phenylalanine.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Basophils; Calcium; Cell Degranulation; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptor Aggregation; Signal Transduction; Sphingosine; SRS-A; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Sphingosine inhibition and promotion of histamine release from isolated rat mast cells.
Topics: Animals; Calcimycin; Calcium; Drug Interactions; Histamine Release; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Macrophages express functional receptors for calcitonin-gene-related peptide.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Calcitonin; Calcitonin Gene-Related Peptide; Carrier Proteins; Cyclic AMP; Hydrogen-Ion Concentration; Macrophages; Peritoneal Cavity; Rats; Receptors, Calcitonin; Receptors, Cell Surface; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine.
Topics: Blood Platelets; Cell Adhesion Molecules; Cell Line; Down-Regulation; Flow Cytometry; Humans; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Ristocetin; Sphingosine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa | 1991 |
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Sphingosine reverses growth inhibition caused by activation of protein kinase C in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cells, Cultured; Diglycerides; DNA; Enzyme Activation; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Different mechanical transduction mechanisms for the immediate and delayed responses of rat C-fiber nociceptors.
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Electric Stimulation; Evoked Potentials; Gentamicins; Hindlimb; Nerve Fibers; Neurotoxins; Nociceptors; Peripheral Nerves; Physical Stimulation; Potassium Channels; Rats; Rats, Inbred Strains; Scorpion Venoms; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Angiotensin II receptor subtypes in rat early proximal tubule.
Topics: Angiotensin II; Animals; Calcium; Kidney Tubules, Proximal; Male; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
A protein kinase C-like activity in Escherichia coli.
Topics: Antibodies, Monoclonal; Calcium; Cross Reactions; Diglycerides; Escherichia coli; Isoenzymes; Protein Kinase C; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1991 |
Regulation of the antigen-induced F-actin response in rat basophilic leukemia cells by protein kinase C.
Topics: Actins; Alkaloids; Animals; Antibodies, Monoclonal; Antigens, Differentiation, B-Lymphocyte; Calcium; Carbazoles; Cell Line; Diglycerides; Immunoglobulin E; Indole Alkaloids; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Leukemia, Experimental; Macromolecular Substances; Protein Kinase C; Rats; Receptors, Fc; Receptors, IgE; Serotonin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
The participation of annexin II (calpactin I) in calcium-evoked exocytosis requires protein kinase C.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Annexins; Calcium-Binding Proteins; Cattle; Cell Membrane Permeability; Exocytosis; Kinetics; Membrane Proteins; Norepinephrine; Phosphorylation; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Sphingosine synergistically stimulates tumor necrosis factor alpha-induced prostaglandin E2 production in human fibroblasts.
Topics: Cell Line; Dinoprostone; Drug Synergism; Fibroblasts; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Proteins; Sialoglycoproteins; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Calcimycin; Calmodulin; Gene Expression Regulation; Histocompatibility Antigens Class II; Interferon-gamma; Ionomycin; Isoquinolines; Macrophages; Major Histocompatibility Complex; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Trifluoperazine; Tumor Necrosis Factor-alpha | 1991 |
Protein kinase C regulates the synthesis of platelet-activating factor by human monocytes.
Topics: Binding Sites; Calcimycin; Diglycerides; Enzyme Activation; Humans; Kinetics; Leukotriene B4; Monocytes; Opsonin Proteins; Phagocytosis; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Phorbol myristate acetate inhibition of phospholipase C activation by carbachol in slices of rat brain cortex is a delayed and indirect effect.
Topics: Animals; Apamin; Calcium; Carbachol; Cerebral Cortex; Enzyme Activation; In Vitro Techniques; Male; Nerve Tissue Proteins; Phosphatidylinositols; Phosphorylation; Potassium; Rats; Rats, Inbred Strains; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1991 |
Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Affinity Labels; Animals; Cell Line; Cell Membrane; Cloning, Molecular; Cricetinae; Cricetulus; Humans; Isoquinolines; Phosphorylation; Photochemistry; Piperazines; Precipitin Tests; Protein Kinase C; Receptors, Serotonin; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Sphingosine inhibits attachment of murine Lewis lung carcinoma cells to laminin and type IV collagen.
Topics: Animals; Cell Adhesion; Collagen; Extracellular Matrix Proteins; Laminin; Lung Neoplasms; Mice; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Effects of sphingosine on phorbol ester-mediated changes in astrocyte morphology and protein phosphorylation.
Topics: Animals; Astrocytes; Glial Fibrillary Acidic Protein; Nerve Tissue Proteins; Phosphorylation; Sphingosine; Tetradecanoylphorbol Acetate; Vimentin | 1991 |
C20 polyunsaturated fatty acids and phorbol myristate acetate enhance agonist-stimulated synthesis of 1-radyl-2-acetyl-sn-glycero-3-phosphocholine in vascular endothelial cells.
Topics: Acetates; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cattle; Endothelium, Vascular; Fatty Acids, Unsaturated; Kinetics; Phosphatidylcholines; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; HeLa Cells; Humans; Insulin; Kinetics; Mice; Mitogens; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Epinephrine; Eye Neoplasms; Humans; Immune Sera; Immunoblotting; Isoquinolines; Kinetics; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Long-chain (sphingoid) bases inhibit multistage carcinogenesis in mouse C3H/10T1/2 cells treated with radiation and phorbol 12-myristate 13-acetate.
Topics: Animals; Biological Transport; Cell Line; Cell Transformation, Neoplastic; Gamma Rays; Kinetics; Mice; Mice, Inbred C3H; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Effects of sphingosine, staurosporine, and phorbol ester on neurites of rat sympathetic neurons growing in compartmented cultures.
Topics: Alkaloids; Animals; Axons; Cells, Cultured; Immunoglobulin G; Microscopy, Phase-Contrast; Nerve Degeneration; Nerve Growth Factors; Neurons; Protein Kinase C; Rats; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate | 1991 |
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Ethanol potentiates the stimulatory effects of phorbol ester, sphingosine and 4-hydroxynonenal on the hydrolysis of phosphatidylethanolamine in NIH 3T3 cells.
Topics: Aldehydes; Animals; Cells, Cultured; Drug Synergism; Ethanol; Hydrolysis; Lipid Metabolism; Mice; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Sphingomyelin synthesis is involved in adherence during macrophage differentiation of HL-60 cells.
Topics: Cell Adhesion; Cell Line; Ceramides; Macrophages; Phosphatidylcholines; Phospholipases; Phosphorylcholine; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Egtazic Acid; Exocytosis; Interphase; Isoquinolines; Oocytes; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Xenopus laevis | 1990 |
Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Diglycerides; Glucose; Glycerol; Inositol; Insecticides; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Phosphates; Piperazines; Protein Kinase Inhibitors; Pyrethrins; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Synergistic activation by serotonin and GTP analogue and inhibition by phorbol ester of cyclic Ca2+ rises in hamster eggs.
Topics: Aequorin; Animals; Calcium; Cricetinae; Drug Synergism; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Potentials; Mesocricetus; Ovum; Protein Kinase C; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock.
Topics: Aminoquinolines; Calcium; Calcium Channel Blockers; Cell Survival; Chromatin; Cold Temperature; Cytosol; DNA; Endonucleases; Flunarizine; Fluorescent Dyes; Humans; Imidazoles; Kinetics; Sphingosine; Synovial Membrane; Tetradecanoylphorbol Acetate | 1990 |
Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.
Topics: Blood Physiological Phenomena; Cell Differentiation; Humans; Leukemia, Promyelocytic, Acute; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate; Tretinoin | 1990 |
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Topics: Adenylyl Cyclases; Alkaloids; Animals; Cells, Cultured; Chorionic Gonadotropin; Corticotropin-Releasing Hormone; Cyclic AMP; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Leydig Cells; Male; Protein Kinase C; Rats; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate | 1990 |
Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils.
Topics: Antigens, CD; Calcimycin; Cell Aggregation; Cerebrosides; Galactosylceramides; Globosides; Glycolipids; Glycosphingolipids; Humans; Lactosylceramides; Leukotriene B4; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Psychosine; Sphingolipids; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate; Trihexosylceramides | 1990 |
Sphingosine differentially inhibits activation of the Na+/H+ exchanger by phorbol esters and growth factors.
Topics: Animals; Animals, Newborn; Biological Transport; Carrier Proteins; Cells, Cultured; Detergents; Diglycerides; Hydrogen-Ion Concentration; Kinetics; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Platelet-Derived Growth Factor; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol.
Topics: Adipose Tissue; Alkaloids; Animals; Bucladesine; Dexamethasone; Drug Synergism; Enzyme Activation; Growth Hormone; Hypophysectomy; Isoproterenol; Lipolysis; Male; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Theophylline | 1990 |
Inhibitory effect of phorbol ester on sodium transport in frog urinary bladder.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arginine Vasopressin; Biological Transport; Colforsin; Cyclic AMP; Diglycerides; Rana catesbeiana; Sodium; Sphingosine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1990 |
Modulation of phosphoinositide metabolism in aortic smooth muscle cells by allylamine.
Topics: Allylamine; Animals; Aorta; Bucladesine; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Male; Muscle, Smooth, Vascular; Phosphatidylinositols; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Sphingosine; Tetradecanoylphorbol Acetate; Theophylline | 1990 |
Phosphatidylcholine breakdown in HDL3 stimulated platelets.
Topics: Blood Platelets; Diacylglycerol Kinase; Diglycerides; Humans; In Vitro Techniques; Lipoproteins, HDL; Lipoproteins, HDL3; Phosphatidic Acids; Phosphatidylcholines; Phosphotransferases; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Neuritogenesis in cerebellar granule cells in vitro: a role for protein kinase C.
Topics: Alkaloids; Animals; Aspartic Acid; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Dendrites; Enzyme Inhibitors; N-Methylaspartate; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Differential down-regulation of protein kinase C selectively affects IgE-dependent exocytosis and inositol trisphosphate formation.
Topics: Animals; Antigens; Down-Regulation; Enzyme Activation; Exocytosis; Immunoglobulin E; Inositol 1,4,5-Trisphosphate; Leukemia, Experimental; Mast Cells; Molecular Weight; Phosphoproteins; Protein Kinase C; Rats; Receptors, Immunologic; Serotonin; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1990 |
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
Topics: Animals; Cell Division; Cell Line; DNA Replication; Epidermal Growth Factor; Glycerol; Inositol; Insulin; Kinetics; Mice; Phosphates; Phosphatidic Acids; Sphingosine; Tetradecanoylphorbol Acetate; Thymidine | 1990 |
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; DNA; Down-Regulation; Drug Synergism; Fibroblasts; Growth Substances; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated wi
Topics: Alkaloids; Blood; Cell Division; Cell Line; Down-Regulation; Enzyme Activation; Growth Hormone; Humans; Kinetics; Lymphocytes; Molecular Weight; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, Somatotropin; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: studies with hydrogen peroxide and phorbol ester.
Topics: Biological Transport; Cell Line; Dexamethasone; Fibroblasts; Glucocorticoids; Glucose; Hydrogen Peroxide; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors.
Topics: Alkaloids; Blood Platelets; Carbazoles; Diglycerides; Drug Synergism; Enzyme Activation; Feedback; Glycerides; Humans; Indole Alkaloids; Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phosphorylation; Propranolol; Protein Kinase C; Second Messenger Systems; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance | 1990 |
Protein kinase C is present in human sperm: possible role in flagellar motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Activation of protein kinase C triggers premature compaction in the four-cell stage mouse embryo.
Topics: Animals; Cadherins; Cell Compartmentation; Cleavage Stage, Ovum; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Immunologic Techniques; Mice; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Weak inhibition of protein kinase C coupled with various non-specific effects make sphingosine an unsuitable tool in platelet signal transduction studies.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Calcium; Ethers; Humans; In Vitro Techniques; Ionomycin; Kinetics; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Evidence for an inhibitory effect of protein kinase C on G-protein-mediated repetitive calcium transients in hamster eggs.
Topics: Animals; Calcium; Cricetinae; Diglycerides; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Mesocricetus; Ovum; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells.
Topics: Cell Adhesion; Cell Differentiation; Cell Division; Humans; Leukemia, Promyelocytic, Acute; Phosphoric Diester Hydrolases; Protein Kinase C; Sphingolipids; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Sphingosine inhibits phorbol 12-myristate 13-acetate-, but not serum-induced, activation of Na+/H+ exchange in mammalian cells.
Topics: Animals; Blood Physiological Phenomena; Carrier Proteins; Cell Line; Diglycerides; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Dimethylsulfoxide modifies the sensitivity of BALB/c-3T3 cells to the activation of Na+/H+ exchange by phorbol esters.
Topics: Animals; Blood Physiological Phenomena; Carrier Proteins; Cell Line; Dimethyl Sulfoxide; Drug Resistance; Fibroblasts; Hydrogen-Ion Concentration; Kinetics; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Effects of luminal Na+ on single Na+ channels in A6 cells, a regulatory role for protein kinase C.
Topics: Amiloride; Animals; Calcimycin; Cell Line; Diglycerides; Electric Conductivity; Homeostasis; Kidney; Kinetics; Protein Kinase C; Sodium; Sodium Channels; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester transiently increases topoisomerase I mRNA levels in human skin fibroblasts.
Topics: Binding, Competitive; DNA Topoisomerases, Type I; Fibroblasts; Gene Expression Regulation; Humans; Protein Kinase C; RNA, Messenger; Skin; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
A role for protein kinase C in the membrane fusion necessary for platelet granule secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Blood Platelets; Calcimycin; Carrier Proteins; Cytoplasmic Granules; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Membrane Fusion; Membrane Potentials; Phosphoproteins; Piperazines; Platelet Aggregation; Protein Kinase C; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C is involved in laminin stimulation of neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Chick Embryo; Concanavalin A; Cyclic AMP; Extracellular Matrix; Ganglia, Parasympathetic; Isoquinolines; Laminin; Motor Neurons; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Escherichia coli; Fimbriae, Bacterial; Granulocytes; Indole Alkaloids; Isoquinolines; Luminescent Measurements; Macrophage Activation; Macrophages; Mannose; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Epidermis; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.
Topics: Adipose Tissue; Animals; Biological Transport; Cells, Cultured; Glucose; Hexoses; In Vitro Techniques; Insulin; L-Lactate Dehydrogenase; Oxidation-Reduction; Protein Kinase C; Rats; Rats, Inbred Strains; Receptor, Insulin; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1989 |
Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.
Topics: Adipose Tissue; Animals; Cells, Cultured; Glucose; Growth Hormone; Insulin; Kinetics; Lipids; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Receptor, Insulin; Receptors, Somatotropin; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1989 |
A further comparison of insulin- and phorbol ester-stimulated glucose transport in adipocytes.
Topics: Adenosine Triphosphate; Adipose Tissue; Alkaloids; Animals; Arsenicals; Biological Transport, Active; Cell Fractionation; Cell Survival; Deoxyglucose; Glucose; In Vitro Techniques; Insulin; Kinetics; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
A reassessment of guanine nucleotide effects on catecholamine secretion from permeabilized adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Bacterial Toxins; Calcium; Cattle; Cell Membrane Permeability; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hemolysin Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Neurotoxins; Norepinephrine; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Line; Cell Nucleus; Ethanol; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C.
Topics: Adenine Nucleotides; Animals; Bacterial Toxins; Bradykinin; Calcium; Cations, Divalent; Cattle; Cytoplasm; Endothelium; Hemolysin Proteins; In Vitro Techniques; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Regulation of eicosanoid synthesis in mouse peritoneal macrophages by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Diglycerides; Dinoprostone; Isoquinolines; Macrophages; Mice; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Differential effects of long-chain (sphingoid) bases on the monocytic differentiation of human leukemia (HL-60) cells induced by phorbol esters, 1 alpha, 25-dihydroxyvitamin D3, or ganglioside GM3.
Topics: Antigens, Neoplasm; Antigens, Surface; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Cell Survival; G(M3) Ganglioside; Gangliosides; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils.
Topics: Acetyltransferases; Chromatography, Gas; Diglycerides; Enzyme Activation; Humans; Neutrophils; Opsonin Proteins; Phagocytosis; Platelet Activating Factor; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Topics: Animals; Cell Differentiation; Cell Division; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Neutrophils; Oxygen; Protein Kinase C; Sphingosine; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1989 |
Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion.
Topics: Alkaloids; Animals; Antilymphocyte Serum; Cell Line; Interleukin-1; Interleukin-2; Mice; Phorbol Esters; Phytohemagglutinins; Protein Kinase C; Sphingosine; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.
Topics: Amines; Enzyme Activation; Humans; Leukotriene B4; Neutrophils; Palmitoylcarnitine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
Topics: Calcimycin; Glucuronidase; Humans; In Vitro Techniques; Kinetics; Lactoferrin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1987 |
Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chlorpromazine; Diglycerides; Ethers; Glycerides; Glyceryl Ethers; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase C; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.
Topics: Diglycerides; Glycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Phosphatidylinositols; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Phorbol esters specifically enhance the cytolytic activity of Entamoeba histolytica.
Topics: Adhesiveness; Animals; Cell Adhesion; Cell Line; Cell Survival; Clone Cells; Cricetinae; Cricetulus; Entamoeba histolytica; Female; Ovary; Sphingosine; Tetradecanoylphorbol Acetate; Virulence | 1988 |
Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures.
Topics: Animals; Aspartic Acid; Carbachol; Cerebellum; Diglycerides; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; N-Methylaspartate; Neurons; Oxadiazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
Response of aequorin-loaded platelets to activators of protein kinase C.
Topics: Aequorin; Aminoquinolines; Blood Platelets; Calcium; Cytosol; Diglycerides; Enzyme Activation; Fluorescent Dyes; Glycerides; Humans; Indicators and Reagents; Luminescent Proteins; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Sphingosine; Tetradecanoylphorbol Acetate; Thrombin | 1989 |
Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate.
Topics: Animals; Enzyme Induction; Mice; Ornithine Decarboxylase; Skin; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
The lack of a role for protein kinase C in neurite extension and in the induction of ornithine decarboxylase by nerve growth factor in PC12 cells.
Topics: Adrenal Gland Neoplasms; Axons; Cycloheximide; Dactinomycin; Drug Synergism; Enzyme Induction; Kinetics; Mutation; Nerve Growth Factors; Neurons; Ornithine Decarboxylase; Pheochromocytoma; Protein Kinase C; Second Messenger Systems; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Abdomen; Action Potentials; Animals; Aplysia; Calcium; Electrophysiology; Ganglia; Isoquinolines; Neurons; Neuropeptides; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane; Cell Survival; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells.
Topics: Burkitt Lymphoma; Butyrates; Butyric Acid; Cells, Cultured; Deoxyribonucleases; DNA-Directed DNA Polymerase; DNA, Viral; Enzyme Induction; Genes, Viral; Herpesvirus 4, Human; Humans; Methylation; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1987 |
Phorbol esters potentiate rapid dopamine release from median eminence and striatal synaptosomes.
Topics: Animals; Calcimycin; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Hyperprolactinemia; Indomethacin; Kinetics; Male; Median Eminence; Phorbol Esters; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Sphingosine; Synaptosomes; Tetradecanoylphorbol Acetate; Tritium; Veratridine | 1988 |
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
Topics: Calcimycin; Culture Media; Humans; In Vitro Techniques; Kinetics; Lipoproteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sphingosine; Tetradecanoylphorbol Acetate; Zymosan | 1988 |
Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Cell Membrane; HLA-DR Antigens; Humans; Interferon-gamma; Isoquinolines; Kinetics; Macrophages; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Membrane; Isoquinolines; Kinetics; Piperazines; Pituitary Gland; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.
Topics: Adrenal Gland Neoplasms; Animals; Cell Survival; Dose-Response Relationship, Drug; Nerve Growth Factors; Neurons; Pheochromocytoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured | 1988 |
Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
Topics: Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; ErbB Receptors; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1988 |
A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cell Membrane Permeability; Cells, Cultured; Exocytosis; Kinetics; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin.
Topics: Administration, Topical; Animals; Dermatitis; Enzyme Activation; Mice; Mice, Hairless; Ornithine Decarboxylase Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.
Topics: Animals; Calcium; Cell Line; Chromatography, High Pressure Liquid; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Inositol Phosphates; Kinetics; Protein Kinase C; Sphingosine; Sugar Phosphates; Tamoxifen; Tetradecanoylphorbol Acetate | 1988 |
Protein kinase C modulates actin conformation in human T lymphocytes.
Topics: Actins; Enzyme Activation; Humans; Protein Conformation; Protein Kinase C; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1988 |
Insulin and phorbol ester stimulate conductive Na+ transport through a common pathway.
Topics: Animals; Diglycerides; Drug Interactions; Enzyme Activation; Insulin; Protein Kinase C; Rana pipiens; Skin; Sodium; Sphingosine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Vasopressins | 1988 |
Prevention of the TPA-mediated down-regulation of protein kinase C.
Topics: Animals; Cattle; Lymphocytes; Palmitoylcarnitine; Phloretin; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1988 |
Biphasic response of Na+-dependent amino acid transport to tumor promoting phorbol esters in cultured renal epithelial cells, LLC-PK1.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Cell Line; Electrochemistry; Epithelium; Kidney; Kinetics; Leucine; Membrane Proteins; Phosphorylation; Protein Kinase C; Sodium; Sphingosine; Swine; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.
Topics: Acid Phosphatase; Binding, Competitive; Cell Adhesion; Cell Differentiation; Cell Line; Humans; Kinetics; Leukemia, Myeloid, Acute; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1986 |
Sphingolipids inhibit insulin and phorbol ester stimulated uptake of 2-deoxyglucose.
Topics: Animals; Biological Transport, Active; Cell Line; Ceramides; Deoxy Sugars; Deoxyglucose; Fibroblasts; Insulin; Insulin Antagonists; Mice; Phorbols; Sphingolipids; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 1986 |
Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX.
Topics: Alkaloids; Animals; Base Sequence; Binding Sites; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; HeLa Cells; Hepatitis B virus; Humans; Isoquinolines; Kinetics; Macromolecular Substances; Molecular Sequence Data; Naphthalenes; Oligodeoxyribonucleotides; Phosphorylation; Polycyclic Compounds; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vaccinia virus; Viral Regulatory and Accessory Proteins | 1994 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Protein kinase C modulates calcium channels in isolated presynaptic nerve terminals of rat hippocampus.
Topics: Animals; Calcium; Calcium Channels; Fura-2; Hippocampus; Kinetics; Naphthalenes; Phorbol Esters; Phosphorylation; Polycyclic Compounds; Potassium; Presynaptic Terminals; Protein Kinase C; Rats; Sodium; Spectrometry, Fluorescence; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
The effect of protein kinase C stimulator and inhibitor on cochlear potentials in the guinea pig.
Topics: Acoustic Stimulation; Action Potentials; Animals; Cochlea; Enzyme Inhibitors; Evoked Potentials, Auditory; Guinea Pigs; Hair Cells, Auditory, Inner; Perfusion; Phorbol Esters; Protein Kinase C; Sphingosine; Synaptic Transmission; Tetradecanoylphorbol Acetate | 1995 |
Effect of protein kinase C modulation on gonadotrophin-induced granulosa cell steroidogenesis.
Topics: Alkaloids; Animals; Cell Differentiation; Cyclic AMP; Female; Gonadotropins, Equine; Granulosa Cells; Pregnancy; Progesterone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Sphingosine derivatives inhibit depolarization-evoked calcium entry in rat GH4C1 cells.
Topics: Animals; Barium; Calcium; Calcium Channels; Calcium Radioisotopes; Cell Line; Diglycerides; Electric Conductivity; Electrophysiology; Fura-2; Lysophospholipids; Patch-Clamp Techniques; Pituitary Gland; Potassium; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1995 |
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cell Division; Cell Nucleus; DNA; DNA-Binding Proteins; Humans; Male; Mice; Molecular Sequence Data; Niemann-Pick Diseases; Oligodeoxyribonucleotides; Phosphorylcholine; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Recombinant Proteins; Salmon; Signal Transduction; Spermatozoa; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 1995 |
Leishmanial protein kinase C modulates host cell infection via secreted acid phosphatase.
Topics: Acid Phosphatase; Animals; Cell Membrane; Flagella; Host-Parasite Interactions; Leishmania mexicana; Macrophages, Peritoneal; Mice; Protein Kinase C; Sphingosine; Tartrates; Tetradecanoylphorbol Acetate | 1995 |
Zymosan-induced tyrosine phosphorylations in human monocytes. Role of protein kinase C.
Topics: Catechols; Genistein; Humans; In Vitro Techniques; Isoflavones; Molecular Weight; Monocytes; Naphthalenes; Nitriles; Phosphoproteins; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine; Tyrphostins; Vanadium; Zymosan | 1993 |
Receptor-independent mechanisms are involved in the priming of neutrophil's oxidase by vasoactive intestinal peptide.
Topics: Calcimycin; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophil Activation; Neutrophils; Receptors, Vasoactive Intestinal Peptide; Respiratory Burst; Somatostatin; Sphingosine; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1994 |
Protein kinase A induces phosphorylation of the human 5-HT1A receptor and augments its desensitization by protein kinase C in CHO-K1 cells.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Heparin; Humans; Kinetics; Phosphorylation; Protein Kinase C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection | 1994 |
Phosphatidylcholine-phospholipase C mediates the induction of nerve growth factor in cultured glial cells.
Topics: Animals; Blotting, Northern; Brain; Cells, Cultured; Enzyme Activation; Hydrolysis; Nerve Growth Factors; Neuroglia; Phosphatidylcholines; Protein Kinase C; Rats; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1995 |
Preferential inhibition of phorbol ester-induced hydrolysis of phosphatidylethanolamine by N-acetylsphingosine in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Carbon Radioisotopes; Fibroblasts; Hydrolysis; Indoles; Kinetics; Maleimides; Mice; Palmitic Acid; Palmitic Acids; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Radioisotope Dilution Technique; Rats; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester stimulates choline uptake in Swiss 3T3 fibroblasts following introduction of the gene encoding protein kinase C alpha.
Topics: 3T3 Cells; Animals; Biological Transport; Blotting, Western; Carbon Radioisotopes; Choline; Dose-Response Relationship, Drug; Isoenzymes; Isotope Labeling; Mice; Phosphatidylcholines; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.
Topics: Apoptosis; Cell Differentiation; Cell Line; Ceramides; DNA Damage; DNA, Neoplasm; Flow Cytometry; Gene Expression; Genes, myc; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Phospholipids; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Tritium; Tumor Cells, Cultured | 1995 |
Opioids induce while nicotine suppresses apoptosis in human lung cancer cells.
Topics: Apoptosis; DNA Damage; DNA, Neoplasm; Drug Synergism; Hexamethonium; Humans; Lung Neoplasms; Methadone; Morphine; Nicotine; Receptors, Cholinergic; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Involvement of protein kinase C in the axonal growth-promoting effect on spinal cord neurons by target-derived astrocytes.
Topics: Animals; Astrocytes; Axons; Cell Polarity; Neurites; Protein Kinase C; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sphingosine; Spinal Cord; Tetradecanoylphorbol Acetate | 1994 |
N,N,N-trimethylsphingosine modifies aggregatory response and ATP release from platelets in whole blood.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Arachidonic Acid; Blood Platelets; Collagen; Humans; Platelet Aggregation; Protein Kinase C; Ristocetin; Sphingosine; Tetradecanoylphorbol Acetate | 1994 |
Modulation of adenylylcyclase by protein kinase C in human neurotumor SK-N-MC cells: evidence that the alpha isozyme mediates both potentiation and desensitization.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Alkaloids; Aluminum Compounds; Animals; Brain; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Dopamine; Drug Synergism; Fluorides; GTP-Binding Proteins; Humans; Isoenzymes; Isoproterenol; Kinetics; Manganese; Neuroblastoma; Neuropeptide Y; Propanolamines; Protein Kinase C; Rats; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells.
Topics: Breast Neoplasms; Drug Resistance, Multiple; Glycerophospholipids; Glycerylphosphorylcholine; Humans; Hydrogen Peroxide; Hydrolysis; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Involvement of protein kinase C in mucus secretion by hamster tracheal epithelial cells in culture.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Cricetinae; Cytosol; Diglycerides; Epithelial Cells; Epithelium; Glycoconjugates; Male; Mesocricetus; Molecular Weight; Mucus; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1994 |
Agents that increase phosphatidic acid inhibit the LH-induced testosterone production.
Topics: Animals; Bucladesine; Calcimycin; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP; Leydig Cells; Luteinizing Hormone; Male; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phospholipase D; Propranolol; Rats; Rats, Sprague-Dawley; Sphingosine; Testosterone; Tetradecanoylphorbol Acetate | 1994 |
Selective down-regulation of protein kinase c-epsilon by carcinogens does not prevent stimulation of phospholipase D by phorbol ester and platelet-derived growth factor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkaloids; Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Isoenzymes; Mice; Mice, Inbred C3H; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Platelet-Derived Growth Factor; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C and adaptation to ethanol.
Topics: Acclimatization; Animals; Calcium; Calcium Channels; Cell Differentiation; Ethanol; Isoenzymes; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1994 |
Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cats; Cell Fractionation; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Enzyme Activation; Epithelium; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Mucins; Piperazines; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1994 |
Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate.
Topics: Animals; Calcium; Cattle; Cell Survival; Cells, Cultured; Deoxyglucose; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Kinetics; Lysophospholipids; Phosphates; Phosphatidic Acids; Phospholipase D; Phospholipids; Phosphorus Radioisotopes; Protein Kinase C; Pulmonary Artery; Ribonucleotides; Sphingosine; Tetradecanoylphorbol Acetate | 1994 |
Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons?
Topics: Alkaloids; Animals; Biological Transport; Calcium; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Chloride; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Bradykinin; Calcium; Calcium-Transporting ATPases; Cytosol; DNA; Egtazic Acid; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Kinetics; Lysophospholipids; Mice; Phorbol Esters; Second Messenger Systems; Sphingosine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors | 1994 |
The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Chelating Agents; Enzyme Activation; Hydrogen Peroxide; Hydrolysis; Mice; Phenanthrolines; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1994 |
Sphingosine-like stimulatory effects of propranolol on phospholipase D activity in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Carbon Radioisotopes; Diglycerides; Drug Synergism; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Propranolol; Sphingosine; Tetradecanoylphorbol Acetate | 1994 |
Hydrogen peroxide regulates phospholipase D-mediated hydrolysis of phosphatidylethanolamine and phosphatidylcholine by different mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Fibroblasts; Hydrogen Peroxide; Hydrolysis; Kinetics; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Sphingosine; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1994 |
A stimulatory role of protein kinase C in feline tracheal submucosal gland secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cats; Glycoconjugates; Glycoproteins; Isoquinolines; Methacholine Chloride; Mucous Membrane; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sodium; Sodium Radioisotopes; Sphingosine; Tetradecanoylphorbol Acetate; Trachea; Tritium | 1993 |
Motility of intracellular particles in rat fibroblasts is greatly enhanced by phorbol ester and by over-expression of normal p21N-ras.
Topics: Animals; Biological Transport; Cell Line; Cytoskeleton; Demecolcine; Dexamethasone; Fibroblasts; Fluorescent Antibody Technique; Gene Expression; Genes, ras; Inclusion Bodies; Microtubules; Precipitin Tests; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Sphingosine; Tetradecanoylphorbol Acetate; Transfection; Video Recording | 1993 |
Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Blood; Culture Media; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Swine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
A bryostatin-sensitive protein kinase C required for nerve growth factor activity.
Topics: Animals; Bryostatins; Cell Differentiation; Enzyme Activation; Genes, fos; Genes, jun; Kinetics; Lactones; Macrolides; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Protein Kinase C; RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Role of protein kinase C in the adaptive increase in Na-H antiporter in respiratory acidosis.
Topics: Acidosis, Respiratory; Adaptation, Physiological; Animals; Cells, Cultured; Hypercapnia; Kidney; Kidney Tubules, Proximal; Microvilli; Protein Kinase C; Rabbits; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1993 |
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Sphingolipids inhibit multistage carcinogenesis and protein kinase C.
Topics: Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Cell Line; Cell Transformation, Neoplastic; Gamma Rays; Mice; Mice, Inbred C3H; Protein Kinase C; Sphingolipids; Sphingosine; Tetradecanoylphorbol Acetate | 1993 |
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Sphingosine mobilizes intracellular calcium in human neutrophils.
Topics: Biological Transport; Calcium; Cell Compartmentation; Cell Death; Dose-Response Relationship, Drug; Edetic Acid; Fluorescent Dyes; Fura-2; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Ionomycin; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylcholine; Saponins; Sphingosine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation.
Topics: Cell Line; Down-Regulation; Enzyme Activation; Humans; Insulin; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptor, Insulin; Sphingosine; Tetradecanoylphorbol Acetate | 1993 |
Phorbol ester-stimulated exocytosis in lacrimal gland: PKC might not be the sole effector.
Topics: Alkaloids; Animals; Benzophenanthridines; Bucladesine; Diglycerides; Exocytosis; In Vitro Techniques; Lacrimal Apparatus; Male; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proteins; Rats; Rats, Sprague-Dawley; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Regulation of parathyroid hormone release by protein kinase-C is dependent on extracellular calcium in bovine parathyroid cells.
Topics: Animals; Calcium; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; In Situ Hybridization; Kinetics; Parathyroid Glands; Parathyroid Hormone; Protein Kinase C; RNA, Messenger; Sphingosine; Tamoxifen; Tetradecanoylphorbol Acetate | 1993 |
Down-regulation of protein kinase C and kinase inhibitors dissociate short- and long-term enhancement produced by one-trial conditioning of Hermissenda.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brachyura; Conditioning, Classical; Down-Regulation; Isoquinolines; Neuronal Plasticity; Photic Stimulation; Photoreceptor Cells; Piperazines; Protein Kinase C; Serotonin; Sphingosine; Tetradecanoylphorbol Acetate | 1993 |
Sphingosine blocks both membrane fusion and calmodulin-dependent phosphorylation of the 100-kDa protein of chick embryonic myoblasts.
Topics: Animals; Calmodulin; Chick Embryo; Egtazic Acid; Membrane Fusion; Muscle Proteins; Muscles; Phosphorylation; Sphingosine; Tetradecanoylphorbol Acetate; Trifluoperazine | 1993 |
Differential effects of the phorbol ester TPA on DNA-mediated transfection in a variety of cell lines.
Topics: 3T3 Cells; Animals; Cell Membrane; Cytosol; Enzyme Activation; HeLa Cells; Humans; Mice; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
The mechanism of sphingosine enhancement of phorbol ester-mediated phospholipase D activation in lymphocytes.
Topics: Animals; Arachidonic Acid; Biological Transport; Cattle; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycerophospholipids; Lymphocyte Activation; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets.
Topics: Blood Platelets; Cell-Free System; Ceramides; Enzyme Inhibitors; Humans; In Vitro Techniques; Lysophospholipids; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation; Sphingosine; Tetradecanoylphorbol Acetate | 1996 |
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Topics: Alkaloids; Animals; Bryostatins; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Lactones; Macrolides; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thioguanine | 1995 |
[The effect of thyroid hormones, phorbol esters, and sphingosine on incorporation of linoleic acid in liver lipids of white rats].
Topics: Animals; Carbon Radioisotopes; Cholesterol Esters; Linoleic Acid; Linoleic Acids; Lipid Metabolism; Liver; Male; Rats; Rats, Wistar; Sphingosine; Tetradecanoylphorbol Acetate; Thyroxine | 1995 |
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.
Topics: Animals; Apoptosis; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Endothelium, Vascular; Flow Cytometry; Glomerular Mesangium; HL-60 Cells; Humans; Kinetics; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Umbilical Veins | 1996 |
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate | 1996 |
Relationship among cellular diacylglycerol, sphingosine formation, protein kinase C activity, and parathyroid hormone secretion from dispersed bovine parathyroid cells.
Topics: Animals; Calcium; Cattle; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; Parathyroid Glands; Parathyroid Hormone; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Pyrimidinones; Sphingosine; Tetradecanoylphorbol Acetate; Thiazoles | 1996 |
Okadaic acid, sphingosine, and phorbol ester reversibly modulate heat induction on protein kinase FA/GSK-3 alpha in A431 cells.
Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Induction; Enzyme Inhibitors; Ethers, Cyclic; Glycogen Synthase Kinase 3; Hot Temperature; Humans; Molecular Sequence Data; Okadaic Acid; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Induction of apoptotic cell death in hen granulosa cells by ceramide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apoptosis; Cells, Cultured; Chickens; Daunorubicin; Female; Fumonisins; Granulosa Cells; Mycotoxins; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1996 |
When do human macrophages release nitric oxide? Variable effects of certain in vitro cultural and in vivo resident conditions.
Topics: Adult; Aged; Animals; Calcimycin; Calcium; Cells, Cultured; Edetic Acid; Female; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Middle Aged; Nitric Oxide; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate | 1996 |
[The role of thyroid hormones in the regulation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide synthesis in liver cells].
Topics: Animals; Liver; Male; Palmitic Acid; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Sphingosine; Tetradecanoylphorbol Acetate; Thyroxine | 1996 |
Measurement of in vitro P-selectin expression by flow cytometry.
Topics: Blood Platelets; Carcinogens; Enzyme Inhibitors; Flow Cytometry; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1.
Topics: 3T3 Cells; Animals; Antibodies; Binding, Competitive; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Ceramides; Cholera Toxin; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; G(M1) Ganglioside; Lysophospholipids; Mice; Mitogens; Peptide Fragments; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Sphingolipids; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1996 |
Study of protein kinase C antagonists on cortical granule exocytosis and cell-cycle resumption in fertilized mouse eggs.
Topics: Alkaloids; Animals; Benzophenanthridines; Cell Cycle; Cell Degranulation; Enzyme Inhibitors; Exocytosis; Humans; Indoles; Male; Maleimides; Mice; Phenanthridines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Zygote | 1997 |
Induction of oligodendrocyte apoptosis by C2-ceramide.
Topics: Animals; Apoptosis; Brain; Cattle; Cells, Cultured; Diglycerides; DNA Fragmentation; Kinetics; Microscopy, Electron; Oligodendroglia; Phospholipases A; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Topics: Animals; Biological Transport; Calcium; Cells, Cultured; Cyclic AMP; Enzyme Activation; Inositol Phosphates; Intracellular Membranes; Liver; Lysophospholipids; Male; Phosphorylases; Rats; Rats, Wistar; Signal Transduction; Sodium Fluoride; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; ADP Ribose Transferases; Animals; Botulinum Toxins; Cell Adhesion Molecules; Cell Division; Cytoskeletal Proteins; DNA Replication; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Proteins; rho GTP-Binding Proteins; Second Messenger Systems; Sphingosine; Stimulation, Chemical; Suramin; Tetradecanoylphorbol Acetate | 1997 |
Inhibitory action of sphingosine or ceramide on amylase secretion from isolated rat pancreatic acini.
Topics: Amylases; Animals; Calcimycin; Carbachol; In Vitro Techniques; Male; Pancreas; Rats; Rats, Wistar; Sincalide; Sodium Fluoride; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Bridged-Ring Compounds; Chromatin; Culture Media, Serum-Free; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; fas Receptor; Humans; Kinetics; Leukemia, Myeloid; Norbornanes; Nucleosomes; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism.
Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Cell Line; Humans; Inositol Phosphates; Lysophospholipids; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Sphingosine prevents diacylglycerol signaling to mitogen-activated protein kinase in airway smooth muscle.
Topics: 1-Butanol; Animals; Bradykinin; Butanols; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diacylglycerol Kinase; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Muscle, Smooth; Palmitic Acid; Phosphatidate Phosphatase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Platelet-Derived Growth Factor; Protein Kinase C; Quinazolines; Quinazolinones; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1997 |
Isoform specificity of activators and inhibitors of protein kinase C gamma and delta.
Topics: Acetophenones; Alkaloids; Benzophenanthridines; Benzopyrans; Bryostatins; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Lactones; Macrolides; Maleimides; Naphthalenes; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Schizosaccharomyces; Sphingosine; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1997 |
Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Cell Cycle; Cell Division; Cell Line; Cell Membrane Permeability; Ceramides; Drug Synergism; Enzyme Activation; Mice; Phospholipase D; Phospholipids; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; DNA; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Ethanolamine; Flavonoids; Gene Expression Regulation, Enzymologic; Hydrolysis; Insulin; Lysophospholipids; Mice; Mitogens; Mitosis; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells.
Topics: Animals; Cell Differentiation; Cell Size; Lysophospholipids; Neurites; PC12 Cells; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Cell Surface; Sphingosine; Tetradecanoylphorbol Acetate | 1997 |
Ursodeoxycholic acid enhances glucocorticoid-induced tyrosine aminotransferase-gene expression in cultured rat hepatocytes.
Topics: Animals; Biomarkers; Calcimycin; Cells, Cultured; Dactinomycin; Dexamethasone; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Ionophores; Liver; Male; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Glucocorticoid; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Tyrosine Transaminase; Up-Regulation; Ursodeoxycholic Acid | 1997 |
Serine base exchange enzyme activity is modulated by sphingosine and other amphiphilic compounds: possible role of positive charge in increasing the synthesis of phosphatidylserine.
Topics: Animals; Cholesterol Esters; Glioma; Kinetics; Microsomes; Microsomes, Liver; Nitrogenous Group Transferases; Phosphatidylserines; Phosphorylcholine; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1997 |
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes.
Topics: Apoptosis; Caspase 3; Caspase 6; Caspase 7; Caspases; Cysteine Endopeptidases; Enzyme Activation; fas Receptor; Humans; Jurkat Cells; Lamin Type B; Lamins; Lysophospholipids; Models, Biological; Nuclear Proteins; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
Sphingosine 1-phosphate activation of MAP kinase--involvement of PI 3-kinase and protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Indoles; Lysophospholipids; Maleimides; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Protein Kinase C; Respiratory System; Sphingosine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
Assay to determine the isoform specificity of protein kinase C inhibitors.
Topics: Alkaloids; Animals; Benzophenanthridines; Cloning, Molecular; Enzyme Inhibitors; Isoenzymes; Kinetics; Mammals; Naphthalenes; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Schizosaccharomyces; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1997 |
The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway.
Topics: Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Carcinoma, Squamous Cell; Enzyme Activation; Enzyme Induction; Genistein; Glycogen Synthase Kinase 3; Humans; Phosphorylation; Phosphotyrosine; Protein Kinase C; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1998 |
Proliferation of adult rat hepatocytes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine.
Topics: Adrenergic alpha-Antagonists; Animals; Cell Division; Cells, Cultured; DNA Replication; Drug Synergism; Enzyme Inhibitors; Estrenes; Ionomycin; Liver; Male; Phenylephrine; Platelet-Derived Growth Factor; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Suramin; Tetradecanoylphorbol Acetate | 1998 |
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
Topics: Alkaloids; Apoptosis; Benzophenanthridines; Calcitriol; Carcinogens; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Enzyme Inhibitors; HL-60 Cells; Humans; Lysophospholipids; Phenanthridines; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Humans; Leukemia, Monocytic, Acute; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
The production of free oxygen radicals and nitric oxide in the rat cochlea.
Topics: Animals; Cochlea; Enzyme Inhibitors; Luminescent Measurements; Nitric Oxide; Protein Kinase C; Rats; Rats, Wistar; Reactive Oxygen Species; Sphingosine; Tetradecanoylphorbol Acetate | 1998 |
Sphingosine modulates interleukin-6 synthesis in osteoblasts.
Topics: Alprostadil; Animals; Bucladesine; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Dinoprost; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Immunoenzyme Techniques; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
Topics: Animals; Brimonidine Tartrate; Cell Count; Cell Division; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Drug Interactions; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Isoquinolines; Liver; Male; Metaproterenol; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Ceramide can induce cell death in sensory neurons, whereas ceramide analogues and sphingosine promote survival.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Ceramides; Endocannabinoids; Enzyme Inhibitors; Ethanolamines; Glucosyltransferases; Mice; Neurons, Afferent; Oleic Acids; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1998 |
Sphingosine induces phospholipase D and mitogen activated protein kinase in vascular smooth muscle cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Diacylglycerol Kinase; Enzyme Activation; Ethanol; Glycerophospholipids; Muscle, Smooth, Vascular; Phosphatidic Acids; Phospholipase D; Piperidines; Protein Kinase C; Quinazolines; Quinazolinones; Rats; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1998 |
Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase Inhibitors; Caspases; Catalysis; Enzyme Activation; Enzyme Induction; Humans; Lysophospholipids; Poly(ADP-ribose) Polymerases; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Na+/H+ antiporter activity in hamster embryos is activated during fertilization.
Topics: Amiloride; Animals; Antiporters; Calcium; Chelating Agents; Chloride-Bicarbonate Antiporters; Cricetinae; Egtazic Acid; Embryo, Mammalian; Fertilization; Hydrogen-Ion Concentration; Mesocricetus; Oocytes; Protein Kinase C; Protein Synthesis Inhibitors; Sodium; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1999 |
Possible involvement of caspase-like family in maintenance of cytoskeleton integrity.
Topics: 3T3 Cells; Animals; Asparagine; Bradykinin; Caspase 3; Caspase Inhibitors; Caspases; Cell Adhesion; Cell Adhesion Molecules; Cell Size; Cysteine Proteinase Inhibitors; Cytoskeleton; Enzyme Induction; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lysophospholipids; Mice; Oligopeptides; Protein-Tyrosine Kinases; Sphingosine; Tetradecanoylphorbol Acetate | 1999 |
Sphingosylphosphorylcholine activates Gq, Gi-2, and Gi-3 in thyroid FRTL-5 cells: implications for the activation of calcium fluxes and Na+-H+ exchange.
Topics: Animals; Base Sequence; Biopolymers; Calcium; Cell Line; DNA Primers; GTP-Binding Proteins; Ion Transport; Phosphorylcholine; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1999 |
Effect of Rho and ADP-ribosylation factor GTPases on phospholipase D activity in intact human adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenylyl Cyclases; ADP Ribose Transferases; ADP-Ribosylation Factors; Botulinum Toxins; Bradykinin; Brefeldin A; Golgi Apparatus; GTP-Binding Proteins; GTPase-Activating Proteins; Humans; Lysophospholipids; Phospholipase D; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Effect of ceramide on interleukin-6 synthesis in osteoblast-like cells.
Topics: Alprostadil; Animals; Bucladesine; Calcimycin; Cell Line; Cholera Toxin; Colforsin; Dinoprost; Interleukin-1; Interleukin-6; Mice; Osteoblasts; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Tumor Necrosis Factor-alpha | 1999 |
Sphingosine and phorbol ester modulate protein kinase C activity and modify ATP-evoked calcium mobilization in glioma C6 cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Endoplasmic Reticulum; Enzyme Activation; Glioma; Indoles; Maleimides; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors; Tumor Cells, Cultured; Type C Phospholipases | 1999 |
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering.
Topics: 3T3 Cells; Animals; Enzyme-Linked Immunosorbent Assay; Lysophospholipids; MAP Kinase Kinase 1; Mast Cells; Mice; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, IgE; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcriptional Activation; Tumor Necrosis Factor-alpha | 1999 |
Ap4A induces apoptosis in human cultured cells.
Topics: 3T3 Cells; Animals; Apoptosis; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Ceramides; Dinucleoside Phosphates; DNA; Humans; Leukemia, Myeloid; Mice; Phorbol Esters; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells.
Topics: Brain Neoplasms; Enzyme Activation; Glioma; Lysophospholipids; Phospholipase D; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin.
Topics: 3T3 Cells; Animals; Bradykinin; Calcimycin; Cell Membrane; DNA, Complementary; Egtazic Acid; Enzyme Activation; Gelsolin; Humans; Isoenzymes; Kinetics; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phospholipase D; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-epsilon; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Brimonidine Tartrate; Cell Division; Cells, Cultured; Dexamethasone; DNA; Dose-Response Relationship, Drug; Drug Interactions; ErbB Receptors; Isoquinolines; Liver; Male; Metaproterenol; Mitogen-Activated Protein Kinase Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Quinoxalines; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor alpha; Type C Phospholipases | 1999 |
Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
Topics: Female; Humans; Insulin-Like Growth Factor II; Lysophospholipids; Nuclear Proteins; Ovarian Neoplasms; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Response Elements; RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factors | 1999 |
Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes.
Topics: Animals; Apoptosis; Base Sequence; Cells, Cultured; Fetus; Genes, fos; Genes, jun; Hippocampus; Kinetics; Lysophospholipids; Neurons; Oligodeoxyribonucleotides; Oligodeoxyribonucleotides, Antisense; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Regulatory Sequences, Nucleic Acid; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1999 |
Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi.
Topics: Animals; Azepines; Culture Media, Conditioned; Phosphoprotein Phosphatases; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Triazoles; Trypanosoma cruzi | 1999 |
Trilinolein potentiates the pro-aggregating effect of phorbol-12-myristate 13-acetate in human polymorphonuclear leukocytes.
Topics: Cell Aggregation; Cyclic GMP; Drug Synergism; Enzyme Activation; Free Radicals; Humans; Neutrophils; Protein Kinase C; Second Messenger Systems; Sphingosine; Tetradecanoylphorbol Acetate; Triglycerides | 1999 |
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelins; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Glioma; GTP-Binding Proteins; Immediate-Early Proteins; Lysophospholipids; Mitogen-Activated Protein Kinases; Naphthalenes; Pertussis Toxin; Platelet-Derived Growth Factor; Protein Kinase C; Rats; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Ceramide path in human lung cell death.
Topics: Apoptosis; Ceramides; Diglycerides; DNA Fragmentation; Enzyme Activation; Epithelial Cells; Humans; Hydrogen Peroxide; Hydrolysis; Inflammation; Lung; Membrane Lipids; Oxidative Stress; Protein Kinase C; Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate | 2000 |
Receptor-activated phospholipase D is present in caveolin-3-enriched light membranes of C2C12 myotubes.
Topics: Animals; Bradykinin; Caveolin 3; Caveolins; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Enzyme Activation; Isoenzymes; Lysophospholipids; Membrane Proteins; Mice; Mitogens; Muscle, Skeletal; Phospholipase D; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate; Thrombin | 2000 |
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Pregnancy; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uterine Neoplasms | 2000 |
Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester.
Topics: Animals; Brain Neoplasms; Cell Compartmentation; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glioma; Imipramine; Indoles; Isoenzymes; Maleimides; Neoplasm Proteins; Phospholipase D; Propranolol; Protein Kinase C; Rats; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Fractionation; Cell Line; Cell Membrane; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Golgi Apparatus; Indoles; Isoenzymes; Lysophospholipids; Maleimides; Mice; Muscle, Skeletal; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate | 2000 |
Entamoeba invadens: protein kinase C inhibitors block the growth and encystation.
Topics: Alkaloids; Animals; Benzophenanthridines; Entamoeba; Enzyme Inhibitors; Naphthalenes; Phenanthridines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Filopodial behavior is dependent on the phosphorylation state of neuronal growth cones.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Carrier Proteins; Cells, Cultured; Cerebrosides; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Genistein; Growth Cones; Indole Alkaloids; Intracellular Signaling Peptides and Proteins; Models, Biological; Myosin-Light-Chain Kinase; Naphthalenes; Neurons; Okadaic Acid; Phosphorylation; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pseudopodia; Signal Transduction; Snails; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 2000 |
Ceramide-enhanced urokinase-type plasminogen activator (uPA) release is mediated by protein kinase C in cultured microglia.
Topics: Animals; Carbazoles; Carcinogens; Cells, Cultured; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Hydrolysis; Indoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Kinase 4; Microglia; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Receptor, Nerve Growth Factor; Signal Transduction; Sphingomyelin Phosphodiesterase; Sphingomyelins; Sphingosine; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 2000 |
G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells.
Topics: Cell Line; Cell Membrane; GTP-Binding Proteins; Humans; Isoenzymes; Kidney; Kinetics; Lysophospholipids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phorbol 12,13-Dibutyrate; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipase D; Receptors, Cell Surface; Recombinant Proteins; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 2001 |
Platelet-activating factor (PAF) modulates peritoneal mouse macrophage infection by Leishmania amazonensis.
Topics: Animals; Azepines; Female; Leishmania; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Platelet Aggregation Inhibitors; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Triazoles | 2001 |
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
Topics: Animals; Arteriosclerosis; Calcium; Cell Cycle Proteins; Cell Line; Chemotaxis, Leukocyte; Humans; Jurkat Cells; Ligands; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lysophosphatidylcholines; Mitogen-Activated Protein Kinases; Phosphorylcholine; Radioligand Assay; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Signal Transduction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 2001 |
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Ceramides; Culture Media, Serum-Free; Cytochrome c Group; HL-60 Cells; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leukemia; Lysophospholipids; Mitochondria; Mitochondrial Proteins; Protein Transport; Receptors, Tumor Necrosis Factor; Sphingosine; Tetradecanoylphorbol Acetate; U937 Cells | 2001 |
Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells.
Topics: Cell Differentiation; Cell Division; Cell Fractionation; Cell Nucleus; Diglycerides; Dimethyl Sulfoxide; Ethanol; HL-60 Cells; Humans; Insulin-Like Growth Factor I; Isoenzymes; Phospholipase D; Phosphorylcholine; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Solvents; Sphingosine; Tetradecanoylphorbol Acetate | 2002 |
Stimulation of trehalose efflux from cockroach (Periplaneta americana) fat body by hypertrehalosemic hormone is dependent on protein kinase C and calmodulin.
Topics: Animals; Calcium; Calmodulin; Chelating Agents; Diglycerides; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Fat Body; Male; Neuropeptides; Periplaneta; Phosphorylases; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thapsigargin; Trehalose; Trifluoperazine | 2002 |
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA).
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Cell Membrane; Cloning, Molecular; DNA Primers; Enzyme Activation; Green Fluorescent Proteins; Humans; Luminescent Proteins; Lysophospholipids; Molecular Sequence Data; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Transport; Recombinant Fusion Proteins; Sphingosine; Tetradecanoylphorbol Acetate | 2002 |
Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons.
Topics: Animals; Aplysia; Calcium; Cells, Cultured; Electric Stimulation; Enzyme Activators; Enzyme Inhibitors; Large-Conductance Calcium-Activated Potassium Channels; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phloretin; Potassium; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protein Kinase C; Refractory Period, Electrophysiological; Sphingosine; Tetradecanoylphorbol Acetate | 2002 |
Prolactin signaling in porcine adrenocortical cells: involvement of protein kinases.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Androstenedione; Animals; Diglycerides; Enzyme Activators; Enzyme Inhibitors; Female; Genistein; Hydrocortisone; Ionomycin; Phorbol 12,13-Dibutyrate; Prolactin; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Sphingosine; Swine; Tetradecanoylphorbol Acetate | 2002 |
Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.
Topics: Antibodies; CD28 Antigens; CD3 Complex; Cell Division; Culture Media; Dendritic Cells; Flow Cytometry; Gene Expression; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-2; Ionomycin; Lymphocyte Activation; Lysophospholipids; Pertussis Toxin; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2003 |
Selective roles of protein kinase C isoforms on cell motility of GT1 immortalized hypothalamic neurones.
Topics: Acetophenones; Actins; Benzopyrans; Cell Line, Transformed; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Green Fluorescent Proteins; Hypothalamus; Isoenzymes; Luminescent Proteins; Neurons; Phosphoproteins; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein-Tyrosine Kinases; Proteins; Recombinant Fusion Proteins; Retinoblastoma-Like Protein p130; Sphingosine; Tetradecanoylphorbol Acetate; Transfection | 2003 |
Characterization of C2-ceramide-resistant HL-60 subline (HL-CR): involvement of PKC delta in C2-ceramide resistance.
Topics: Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Division; Cell Membrane; Cholecalciferol; Drug Resistance; Eukaryotic Cells; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Isoenzymes; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Sphingosine; Tetradecanoylphorbol Acetate; Tretinoin | 2003 |
Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures.
Topics: Adenoviridae; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Enzyme Activation; Ganglia, Spinal; Genetic Vectors; Herpesvirus 1, Human; Nerve Growth Factors; Nerve Tissue Proteins; Neurons, Afferent; Oligopeptides; Rats; Recombinant Fusion Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Virus Activation; Virus Latency | 2003 |
Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.
Topics: Animals; Carcinogens; Cell Differentiation; Cholecystokinin; Cyclic AMP; Endothelium; Gene Expression; Glucose; GTP-Binding Protein alpha Subunits, Gs; In Vitro Techniques; Insulinoma; Islets of Langerhans; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Possible modulators of IL-8 and GRO-alpha production by granulosa cells.
Topics: Bucladesine; Cell Line, Transformed; Chemokine CXCL1; Chemokines, CXC; Enzyme Activation; Female; Humans; Intercellular Signaling Peptides and Proteins; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-8; Luteal Cells; Protein Kinase C; Sialoglycoproteins; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Line; Cell Line, Tumor; Cytochromes c; Cytosol; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Humans; Jurkat Cells; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 2003 |
Expression and regulation of phospholipase D isoforms in sphingosine and phorbol ester-stimulated glioma C6 cells.
Topics: Base Sequence; Cell Line, Tumor; DNA Primers; Humans; Isoenzymes; Phospholipase D; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate | 2004 |
Sphingosine 1-phosphate breakdown in platelets.
Topics: Blood Platelets; Cell Membrane; Ceramides; Chromatography, High Pressure Liquid; Humans; Lysophospholipids; Models, Biological; Phosphatidate Phosphatase; Phosphorylation; Platelet Activation; Platelet Aggregation; Signal Transduction; Sphingolipids; Sphingomyelins; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 2004 |
Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells.
Topics: 3T3 Cells; Animals; Blotting, Northern; Ceramides; Chemokine CCL2; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression; Genes, fos; Genes, jun; Lysophospholipids; Mice; Mice, Inbred C57BL; Morpholines; Osteoblasts; Propanolamines; Pyrrolidines; Recombinant Proteins; Second Messenger Systems; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2005 |
LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.
Topics: Actins; Animals; Cell Culture Techniques; Diphosphates; Electric Impedance; Endothelium, Corneal; Epithelium, Corneal; Fluorescent Antibody Technique, Indirect; Glycerol; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; Pertussis Toxin; Rabbits; Receptors, Lysophosphatidic Acid; Sphingosine; Tetradecanoylphorbol Acetate | 2005 |
Differential regulation of NPR-B/GC-B by protein kinase c and calcium.
Topics: Animals; Calcium; Cells, Cultured; Guanylate Cyclase; Ionomycin; Lysophospholipids; Natriuretic Peptide, C-Type; Phosphorylation; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Sphingosine; Tetradecanoylphorbol Acetate | 2005 |
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
Topics: Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chemokine CCL2; Chemokine CCL5; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression; Humans; I-kappa B Proteins; Inflammation Mediators; Interleukin-1; Interleukin-6; Ionomycin; Membrane Proteins; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prostaglandin-Endoperoxide Synthases; Protein Precursors; RNA, Small Interfering; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Protein kinases influence bovine oocyte competence during short-term treatment with recombinant human follicle stimulating hormone.
Topics: Adenylyl Cyclases; Animals; Cattle; Cell Survival; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fertilization in Vitro; Follicle Stimulating Hormone; Humans; Oocytes; Oogenesis; Protein Kinase C; Protein Kinases; Recombinant Proteins; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors | 2005 |
The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.
Topics: Amino Acid Sequence; Binding Sites; Calmodulin; Carcinogens; Cell Membrane; Cells, Cultured; Humans; Kidney; Lysophospholipids; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Transport; Sphingosine; Tetradecanoylphorbol Acetate | 2006 |
Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell.
Topics: Calcium; Cell Differentiation; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Lysophospholipids; Protein Kinase C-alpha; Protein Kinase C-epsilon; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 2006 |
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Indicators and Reagents; Lysophospholipids; Mice; o-Phthalaldehyde; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Spectrometry, Fluorescence; Sphingosine; Tetradecanoylphorbol Acetate | 2006 |
Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
Topics: Animals; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Activation; Epidermis; Fibroblasts; Flavonoids; Humans; Indoles; Interleukin-6; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Rabbits; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Wound Healing | 2007 |
Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai.
Topics: Animals; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Trypanosomatina | 2007 |
Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity.
Topics: Cell Adhesion; Cell Communication; Cells, Cultured; Coculture Techniques; Endothelial Cells; Enzyme Activation; Humans; Lysophospholipids; Monocytes; Pertussis Toxin; Protein Kinase C; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate | 2007 |
A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.
Topics: Animals; Cattle; Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Mice; Phosphotransferases (Alcohol Group Acceptor); Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Tetradecanoylphorbol Acetate | 2008 |
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
Topics: Blotting, Western; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Ceramides; Chromatography, High Pressure Liquid; Female; Gene Silencing; Glucosylceramidase; Glucosylceramides; Humans; Lysosomes; Protein Kinase C; RNA, Small Interfering; Sphingomyelins; Sphingosine; Tandem Mass Spectrometry; Tetradecanoylphorbol Acetate | 2009 |
Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells.
Topics: Animals; Apoptosis; Aspartic Acid; Calcimycin; Hydrogen Peroxide; Hypotonic Solutions; Ion Channels; Ionophores; Nitrobenzoates; PC12 Cells; Rats; Sphingosine; Staurosporine; Stereoisomerism; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Topics: Acetylation; Catalytic Domain; Cell Line, Tumor; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Epigenesis, Genetic; Genes, fos; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Lysine; Lysophospholipids; Nucleosomes; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Repressor Proteins; RNA Interference; Sphingosine; Tetradecanoylphorbol Acetate | 2009 |
Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
Topics: Base Sequence; Calcium; Cell Differentiation; Cell Line; DNA Primers; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Macrophages; MAP Kinase Signaling System; Monocytes; Phosphatidylinositol 3-Kinases; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Psychosine; raf Kinases; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; U937 Cells | 2011 |
[Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms].
Topics: Apoptosis; Carcinogens; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; HT29 Cells; Humans; MAP Kinase Kinase 4; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Sphingosine; Tetradecanoylphorbol Acetate; Time Factors | 2011 |
Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation.
Topics: Cell Proliferation; Diglycerides; Enzyme Activation; Enzyme Activators; Gene Knockdown Techniques; Green Fluorescent Proteins; HEK293 Cells; Humans; Indoles; Insulin-Like Growth Factor II; Lysophospholipids; Maleimides; Mesangial Cells; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Kinase C beta; Protein Transport; Receptor, IGF Type 1; Receptor, IGF Type 2; Recombinant Fusion Proteins; RNA Interference; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2011 |
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2012 |
[Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1].
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Humans; Intercellular Adhesion Molecule-1; Neoplasm Invasiveness; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Vascular Cell Adhesion Molecule-1 | 2013 |
Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice.
Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Survival; Dermatitis; Humans; Inflammation; Interleukin-23; Janus Kinase 1; Keratinocytes; Leukocytes, Mononuclear; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Psoriasis; Signal Transduction; Skin; Sphingosine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2014 |
Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway.
Topics: Animals; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Protein Kinase C-alpha; Pulmonary Artery; Rats; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Up-Regulation | 2017 |
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform.
Topics: Human Umbilical Vein Endothelial Cells; Humans; Lab-On-A-Chip Devices; Lysophospholipids; Microfluidic Analytical Techniques; Neovascularization, Physiologic; Sphingosine; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A | 2019 |
S1P
Topics: Enzyme Activation; HEK293 Cells; Humans; Lysophospholipids; Organophosphates; Paroxetine; Phorbol Esters; Phosphorylation; Protein Interaction Maps; Protein Kinase C; rab GTP-Binding Proteins; Receptors, Lysosphingolipid; Sphingosine; Tetradecanoylphorbol Acetate | 2018 |
Pericytes enable effective angiogenesis in the presence of proinflammatory signals.
Topics: Cell Communication; Cell Culture Techniques; Coculture Techniques; Dose-Response Relationship, Drug; Endothelial Cells; Fibroblast Growth Factor 2; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lysophospholipids; Models, Biological; Neovascularization, Pathologic; Neovascularization, Physiologic; Pericytes; Receptors, Notch; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Tissue Engineering; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2019 |