tetradecanoylphorbol acetate has been researched along with sirolimus in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 44 (53.66) | 18.2507 |
| 2000's | 26 (31.71) | 29.6817 |
| 2010's | 12 (14.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bierer, BE; Calvo, V; Crews, CM; Vik, TA | 1 |
| Avruch, J; Bierer, BE; Calvo, V; Grove, JR; Price, DJ | 1 |
| Dumont, FJ; Koprak, SL; Melino, MR; Sigal, NH; Staruch, MJ | 1 |
| Dumont, FJ; Fischer, PA; Koprak, SL; Melino, MR; Sigal, NH; Staruch, MJ | 1 |
| Lin, CS; Siekierka, JJ; Sigal, NH | 1 |
| Forrest, MJ; Jewell, ME; Koo, GC; Sigal, NH | 1 |
| Semerjian, A; Su, MS | 1 |
| Bonnefoy-Berard, N; Dearden-Badet, MT; Genestier, L; Lizard, G; Revillard, JP | 1 |
| Bong, JM; Kobayashi, Y; Ohmoto, Y; Ohsaka, Y; Oka, T; Yasui, H; Yoshimura, N | 1 |
| Blenis, J; Cheatham, L; Chung, J; Grammer, TC; Lemon, KP; Monfar, M; Vlahos, CJ | 1 |
| Burakoff, SJ; Sen, R; Venkataraman, L | 1 |
| Higer, M; Teutsch, M; Wang, D; Wortis, HW | 1 |
| Dennis, PB; Han, JW; Pearson, RB; Thomas, G | 1 |
| Backwell, FR; Mackie, SC; Morrison, KS; Palmer, RM; Pascal, M; Thom, A; Thompson, MG | 1 |
| Dickson, AJ; Yang, SH | 1 |
| Altmeyer, A; Dumont, FJ | 1 |
| Barkis, I; Degiannis, D; Hadjiyannaki-Koniavitou, K; Hornung, N; Raskova, J; Vareltzides, A | 1 |
| Lai, JH; Tan, TH | 1 |
| Dumont, FJ; Kastner, CA | 1 |
| Lawrence, JC; Lin, TA | 1 |
| Chen, H; Daloze, P; Luo, H; St-Louis, G; Wu, J | 1 |
| Hazzalin, CA; Kardalinou, E; Mahadevan, LC; Zhelev, N | 1 |
| Altmeyer, A; Blenis, J; Chung, J; Dumont, FJ; Fischer, PA; Kastner, C; Lemon, KP; Staruch, MJ | 1 |
| Morley, SJ; Pain, VM | 1 |
| Brooks, N; Ryffel, B; Willcocks, JL; Woerly, G | 1 |
| Gingras, AC; Ming, XF; Sonenberg, N; Thomas, G; von Manteuffel, SR | 1 |
| Giasson, E; Meloche, S; Servant, MJ | 1 |
| Parry, RV; Ward, SG | 1 |
| Blenis, J; Monfar, M | 1 |
| Cook, D; Dale, TC; Fry, MJ; Hughes, K; Sumathipala, R; Woodgett, JR | 1 |
| Earp, HS; Graves, LM; Li, X; Yu, H | 1 |
| Kahn, CR; Kim, SJ | 1 |
| Fraser, C; Morley, S | 1 |
| Bragado, MJ; Groblewski, GE; Williams, JA | 2 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Cebrat, M; Gaymes, TJ; Kay, JE; Siemion, IZ | 1 |
| Belfrage, P; Degerman, E; Landström, TR; Manganiello, V; Wijkander, J | 1 |
| Chaidaroglou, A; Degiannis, D; Georgiou, S; Koniavitou, K; Tsambaos, D | 1 |
| Abbal, M; Durand, D; Ohayon, E; Peres, C; Puyoo, O; Rostaing, L; Tkaczuk, J | 1 |
| Goldberg, Y; Piper, HM; Schlüter, KD; Taimor, G | 1 |
| Almawi, WY; Assi, JW; Chudzik, DM; Lazarovits, AI | 1 |
| Bae, GU; Ha, KS; Han, JW; Hong, S; Kwon, HK; Lee, HW; Lee, HY; Lee, ZW; Seo, DW | 1 |
| Miyamoto, S; Safer, B | 1 |
| Law, BK; Moses, HL; Norgaard, P | 1 |
| Coulonval, K; Dumont, JE; Kozma, SC; Lamy, F; Stein, RC; Vandeput, F | 1 |
| Chung, J; Jung, Y; Kim, D; Kim, S; Koh, H | 1 |
| Bao, HF; Eaton, DC; Edinger, RS; Johnson, JP; Yue, G | 1 |
| Kimball, SR; Miyamoto, S; Safer, B | 1 |
| Corwin, JT; Montcouquiol, M | 1 |
| Barten, MJ; Gummert, JF; Morris, RE; Shorthouse, R; van Gelder, T | 2 |
| Iijima, Y; Kuppuswamy, D; Laser, M; McDermott, PJ; Shiraishi, H; Sundaravadivel, B; Willey, CD; Xu, L | 1 |
| Boudreau, RT; Dauphinee, S; Johnson, LM; Li, AW; Sangster, SM; Too, CK | 1 |
| Degiannis, D; Hatziagelaki, E; Koniavitou, K; Raptis, S; Tsiavou, A | 1 |
| Baraban, JM; Beretta, L; Dy, M; Grolleau, A; Machavoine, F; Rolli-Derkinderen, M | 1 |
| Downes, CP; Proud, CG; Tang, X; Wang, L | 1 |
| Helliwell, PA; Kellett, GL; Rumsby, MG | 1 |
| Alexander, GJ; Charman, SC; Gee, I; Trull, AK | 1 |
| Freund, GG; Godbout, JP; Hartman, ME; Mazzocco, VR; Minor, KD; O'Connor, JC | 1 |
| Hanna, NN; Hleb, M; Li, XC; Murphy, S; Padbury, JF; Park, J; Sharma, N; Sharma, S; Strom, TB; Tseng, YT; Wagner, EF | 1 |
| Aeder, SE; Hussaini, IM; Martin, PM; Soh, JW | 1 |
| Fainboim, L; Fuertes, MB; Ilarregui, JM; Molinero, LL; Rabinovich, GA; Rubinstein, N; Toscano, MA; Zwirner, NW | 1 |
| Aeder, SE; Chrestensen, CA; Hussaini, IM; Martin, PM; Sturgill, TW | 1 |
| Magnusson, KE; Navakauskiene, R; Pivoriūnas, A; Savickiene, J; Treigyte, G; Tunaitis, V | 1 |
| Böhler, T; Budde, K; Glander, P; Gurragchaa, P; Kamar, N; Klupp, J; Neumayer, HH; Nolting, J; Reisener, K | 1 |
| Lian, ZX; Shu, SA; Wu, T; Yi, H; Zeng, C; Zhao, Y; Zhen, Y | 1 |
| Kuppuswamy, D; McDermott, PJ; Moschella, PC; Shiraishi, H; Tuxworth, WJ; Yamane, K | 1 |
| Hanai, Y; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Otsuka, T; Takai, S; Tokuda, H | 1 |
| Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H | 1 |
| Chrysanthopoulou, A; Kambas, K; Kourtzelis, I; Mitroulis, I; Rafail, S; Ritis, K; Speletas, M | 1 |
| Checkley, LA; DiGiovanni, J; Hursting, S; Moore, T; Rho, O | 1 |
| Béliveau, È; Guillemette, G; Lapointe, F | 1 |
| DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O | 1 |
| Astorga, UA; Dave, H; Do, MT; He, F; Intriago, RE; Jain, S; Kim, T; Lawson, MA | 1 |
| Angel, JM; Beltran, L; Blando, J; Checkley, LA; Cho, J; DiGiovanni, J; Hursting, SD; Rho, O | 1 |
| Denning, G; Doering, CB; Johnston, JM; Le Doux, JM; Moot, R; Shields, J; Spencer, HT; Whitehead, D | 1 |
| Blagosklonny, MV; Leontieva, OV | 1 |
| Chandrika, G; Chugh, A; Natesh, K; Ranade, D; Shastry, P | 1 |
| Cao, YJ; Du, WX; Huang, YB; Liu, CF; Liu, HH; Shi, LY; Sun, JJ; Wang, F; Yin, XW; Zhang, YL | 1 |
| Wang, S; Xu, S; Yang, Z; Yin, K; Zhang, Q; Zheng, S | 1 |
1 trial(s) available for tetradecanoylphorbol acetate and sirolimus
| Article | Year |
|---|---|
Sirolimus inhibits oxidative burst activity in transplant recipients.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Transplantation; Male; Middle Aged; Reference Values; Respiratory Burst; Sirolimus; Tetradecanoylphorbol Acetate | 2003 |
81 other study(ies) available for tetradecanoylphorbol acetate and sirolimus
| Article | Year |
|---|---|
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Immunoblotting; Immunosuppressive Agents; Interleukin-2; Kinetics; Mice; Molecular Weight; Phosphoproteins; Phosphotyrosine; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromatography, Ion Exchange; Cyclosporine; Immunosuppressive Agents; Insulin; Kinetics; Liver Neoplasms, Experimental; Polyenes; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Transfection | 1992 |
Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.
Topics: Animals; Anti-Bacterial Agents; Cyclosporins; Hybridomas; Immunosuppressive Agents; Interleukin-2; Interleukin-4; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Polyenes; Receptors, Interleukin-2; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate | 1990 |
The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.
Topics: Animals; Anti-Bacterial Agents; Binding, Competitive; Cyclosporins; Gene Expression; Immunosuppressive Agents; In Vitro Techniques; Interleukin-2; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Polyenes; Receptors, Interleukin-2; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate | 1990 |
Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antifungal Agents; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Cells, Cultured; Cyclosporins; Drug Interactions; Humans; Interleukin-2; Ionomycin; Lymphocyte Activation; Polyenes; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate | 1991 |
FK-506 and cyclosporin A: selective inhibition of calcium ionophore-induced polymorphonuclear leukocyte degranulation.
Topics: Anti-Bacterial Agents; Calcimycin; Cycloheximide; Cyclosporins; Dactinomycin; Humans; Immune Tolerance; Ionomycin; Lactoferrin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polyenes; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate | 1991 |
Activation of transcription factor NF kappa B in Jurkat cells is inhibited selectively by FK 506 in a signal-dependent manner.
Topics: Base Sequence; Cell Line; Cyclosporine; Humans; Immunosuppressive Agents; Ionomycin; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Polyenes; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line.
Topics: Animals; Apoptosis; Calcium; Cross-Linking Reagents; Cyclosporine; Immunoglobulin M; Immunosuppressive Agents; Ionomycin; Lymphoma, B-Cell; Mice; Polyenes; Receptors, Antigen, B-Cell; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
The direct effect of FK506 and rapamycin on interleukin 1(beta) and immunoglobulin production in vitro.
Topics: Cell Line; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin M; Immunosuppressive Agents; Interleukin-1; Interleukin-6; Lipopolysaccharides; Macrophages; Polyenes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate | 1994 |
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; In Vitro Techniques; Interleukin-2; Lymphocytes; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Receptors, Interleukin-2; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.
Topics: Amino Acid Sequence; Animals; B-Lymphocytes; Calcineurin; Calmodulin-Binding Proteins; Ionomycin; Mice; Molecular Sequence Data; NF-kappa B; Phosphoprotein Phosphatases; Polyenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Receptors, Antigen, B-Cell; Receptors, Antigen, T-Cell; Receptors, Interleukin-1; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and rapamycin.
Topics: Animals; Antibodies, Anti-Idiotypic; Antigens, CD; Autoimmunity; B-Lymphocytes; Carrier Proteins; CD5 Antigens; Cell Cycle; Cyclosporine; DNA-Binding Proteins; Gene Expression Regulation; Heat-Shock Proteins; Ionomycin; Lymphocyte Activation; Mice; Mice, Inbred CBA; NFATC Transcription Factors; Nuclear Proteins; Polyenes; Sirolimus; T-Lymphocyte Subsets; Tacrolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1995 |
Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites.
Topics: 3T3 Cells; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Blood; Immunosuppressive Agents; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nicotinic Acids; Oligodeoxyribonucleotides; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts.
Topics: Amino Acid Sequence; Animals; Antifungal Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclooxygenase Inhibitors; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Ibuprofen; Indoles; Insulin; Molecular Sequence Data; Muscle Fibers, Skeletal; Polyenes; Protein Biosynthesis; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate | 1995 |
Inhibitors of signalling identify differential control processes responsible for selective effects of insulin on the expression of phosphoenolpyruvate carboxykinase and gene 33 in rat H4 hepatoma cells.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Line; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Insulin; Insulin Antagonists; Intracellular Signaling Peptides and Proteins; Kinetics; Liver Neoplasms, Experimental; Phosphoenolpyruvate Carboxykinase (GTP); Polyenes; Protein Biosynthesis; Rats; RNA, Messenger; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1995 |
Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma.
Topics: Animals; Cell Division; Cell Line; Interferon-gamma; Interleukin-1; Ionomycin; Mice; Polyenes; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Effect of rapamycin on the in vitro release of soluble interleukin-2 receptor by phytohemagglutinin, phorbol myristate acetate, and ionomycin-activated peripheral blood mononuclear cells.
Topics: Cells, Cultured; Cyclosporine; DNA; Humans; Immunosuppressive Agents; Ionomycin; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Polyenes; Receptors, Interleukin-2; Sirolimus; Tetradecanoylphorbol Acetate; Thymidine | 1995 |
CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
Topics: CD28 Antigens; CD4-Positive T-Lymphocytes; Cell Line; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Humans; I-kappa B Proteins; Immunosuppressive Agents; Kinetics; NF-kappa B; NF-KappaB Inhibitor alpha; Polyenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Transcription Factors | 1994 |
Transforming growth factor beta 1 inhibits interleukin-1-induced but enhances ionomycin-induced interferon-gamma production in a T cell lymphoma: comparison with the effects of rapamycin.
Topics: Animals; Cell Division; Drug Interactions; Drug Synergism; Ethers, Cyclic; Immunosuppressive Agents; Interferon-gamma; Interleukin-1; Ionomycin; Lymphoma, T-Cell; Mice; Okadaic Acid; Phosphoprotein Phosphatases; Polyenes; RNA, Messenger; Sirolimus; Swine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Biological Transport; Enzyme Activation; Epidermal Growth Factor; Glucose; Glycogen; Glycogen Synthase; Insulin; Kinetics; Mice; Molecular Sequence Data; Polyenes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 1994 |
Anti-CD28 antibody- and IL-4-induced human T cell proliferation is sensitive to rapamycin.
Topics: Antibodies, Monoclonal; CD28 Antigens; CD3 Complex; Cell Division; Humans; Immunosuppressive Agents; In Vitro Techniques; Interleukin-4; Lymphocyte Activation; Phytohemagglutinins; Polyenes; Receptors, Interleukin-2; Sirolimus; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.
Topics: Amino Acid Sequence; Animals; Anisomycin; Cell Line; Cell Nucleus; Chromatin; Epidermal Growth Factor; Genes, fos; Genes, jun; Genes, Regulator; High Mobility Group Proteins; Histones; Mice; Mice, Inbred C3H; Models, Biological; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Polyenes; Protein Biosynthesis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Ribosomes; Sirolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
Topics: Animals; Antigens, Ly; Clone Cells; Cyclins; Gene Expression; Interferon-gamma; Interleukin-1; Lymphocyte Activation; Lymphoma, T-Cell; Mice; Polyenes; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; Tetradecanoylphorbol Acetate | 1994 |
Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the alpha and gamma subunits of the initiation factor complex eIF-4F.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Concanavalin A; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Immune Sera; Immunoblotting; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Lymphocytes; Macromolecular Substances; Methionine; Molecular Sequence Data; Peptide Initiation Factors; Peptides; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Swine; Tetradecanoylphorbol Acetate | 1995 |
Interleukin-2 receptor (CD25) upregulation on human T-lymphocytes: sensitivity to immunosuppressants is defined by the mode of T-lymphocyte activation.
Topics: Cells, Cultured; Cyclosporine; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Polyenes; Receptors, Interleukin-2; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Cycle Proteins; Cell Line; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Humans; Immunosuppressive Agents; Insulin; Kidney; Kinetics; Mice; Nicotinic Acids; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Growth Substances; Insulin; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Smooth, Vascular; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Sirolimus; Substrate Specificity; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Involvement of phosphatidylinositol 3-kinase in the activation of p70 S6 kinase by the T cell costimulatory molecule CD28.
Topics: Antibodies, Monoclonal; CD28 Antigens; Cell Line; Enzyme Activation; Humans; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Anti-Inflammatory Agents; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucocorticoids; Interleukin-2; Marine Toxins; Mice; Oxazoles; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Culture Media, Conditioned; Drosophila; Drosophila Proteins; Enzyme Inhibitors; Fibroblasts; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Mice; Polyenes; Protein Kinases; Proto-Oncogene Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wnt1 Protein; Wortmannin | 1996 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
Insulin stimulates p70 S6 kinase in the nucleus of cells.
Topics: Animals; Cell Nucleus; CHO Cells; Cricetinae; Dichlororibofuranosylbenzimidazole; Enzyme Activation; Enzyme Inhibitors; Humans; Insulin; Polyenes; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 1997 |
Studies on the phosphorylation of eIF4E in Xenopus (XIK-2) kidney cells.
Topics: Animals; Cell Line; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Immunosuppressive Agents; Indoles; Kidney; Kinetics; Peptide Initiation Factors; Phosphorylation; Polyenes; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate; Xenopus | 1997 |
p70s6k is activated by CCK in rat pancreatic acini.
Topics: Amino Acid Sequence; Androstadienes; Animals; Bombesin; Carbachol; Cells, Cultured; Cholecystokinin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Genistein; Ionomycin; Isoflavones; Kinetics; Male; Molecular Sequence Data; Pancreas; Peptides; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Substrate Specificity; Tacrolimus; Tetradecanoylphorbol Acetate; Thionucleotides; Vasoactive Intestinal Peptide; Wortmannin | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation.
Topics: Amino Acid Sequence; Animals; Calcineurin Inhibitors; Cells, Cultured; Cyclosporine; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Lymphocytes; Molecular Sequence Data; Peptides; Peptides, Cyclic; Peptidylprolyl Isomerase; Phosphorylation; Polyenes; Sirolimus; Swine; Tetradecanoylphorbol Acetate | 1997 |
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Flavonoids; Insulin; Male; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 1998 |
In vitro effects of retinoids on mitogen-induced peripheral blood leucocyte responses.
Topics: Acitretin; Adult; Carcinogens; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Etretinate; Humans; Immunosuppressive Agents; Isotretinoin; Keratolytic Agents; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; Lymphocyte Activation; Lymphocytes; Middle Aged; Mitogens; Phytohemagglutinins; Polyenes; Retinoids; Sirolimus; Tetradecanoylphorbol Acetate | 1998 |
Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
Topics: Androstadienes; Animals; Bombesin; Carbachol; Carrier Proteins; Cholecystokinin; Chromones; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Methionine; Morpholines; Pancreas; Peptide Initiation Factors; Phosphoproteins; Polyenes; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Flow cytometry detection of intracytoplasmic cytokines after Neoral or sirolimus intake is an informative tool for monitoring in vivo immunosuppressive efficacy in renal transplant recipients.
Topics: Cells, Cultured; Cyclosporine; Cytokines; Drug Monitoring; Flow Cytometry; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Ionomycin; Kidney Transplantation; Kinetics; Monitoring, Immunologic; Polyenes; Reference Values; Sirolimus; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells; Time Factors | 1998 |
Intracellular signaling leads to the hypertrophic effect of neuropeptide Y.
Topics: Androstadienes; Animals; Aprotinin; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Creatine Kinase; Cyclic AMP; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; GTP-Binding Proteins; Heart; Heart Ventricles; Isoenzymes; Isoproterenol; Male; Models, Cardiovascular; Myocardium; Neuropeptide Y; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin | 1998 |
Opposing effects of rapamycin and cyclosporin A on activation-induced Ca(2+) release.
Topics: Animals; Calcium; Cell Division; Cell Line; Chelating Agents; Concanavalin A; Cyclosporine; Dose-Response Relationship, Drug; Egtazic Acid; Humans; Immunosuppressive Agents; Ionomycin; Kinetics; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocytes; Sirolimus; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Hydrogen peroxide activates p70(S6k) signaling pathway.
Topics: Androstadienes; Animals; Calcium; Catalase; Cell Line; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Indoles; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation.
Topics: Actins; Cycloheximide; Dactinomycin; Gene Expression Regulation; Humans; Immunosuppressive Agents; Ionomycin; Protein Biosynthesis; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Keratinocytes; Marine Toxins; Methionine; Mice; Oxazoles; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 2000 |
Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hepatocyte Growth Factor; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Wortmannin | 2000 |
Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway.
Topics: 3T3 Cells; Androstadienes; Animals; Chromones; COS Cells; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin; Zinc | 2000 |
The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells.
Topics: Drug Interactions; Enzyme Inhibitors; Epithelial Sodium Channels; Immunophilins; Immunosuppressive Agents; Indoles; Maleimides; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Sirolimus; Sodium Channels; Tacrolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate | 2000 |
Signal transduction pathways that contribute to increased protein synthesis during T-cell activation.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Eukaryotic Initiation Factor-2B; Eukaryotic Initiation Factor-4E; Humans; Ionomycin; Kinetics; Lymphocyte Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated protein kina
Topics: Animals; Anti-Bacterial Agents; Calcium; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Intracellular Fluid; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Ribosomal Protein S6 Kinases; S Phase; Signal Transduction; Sirolimus; Tacrolimus Binding Proteins; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Vestibule, Labyrinth | 2001 |
Assessment of mechanisms of action of immunosuppressive drugs using novel whole blood assays.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD28 Antigens; Concanavalin A; Immunosuppressive Agents; Lymphocyte Activation; Mycophenolic Acid; Rats; Rats, Inbred Lew; Sirolimus; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2001 |
Flow cytometric quantitation of calcium-dependent and -independent mitogen-stimulation of T cell functions in whole blood: inhibition by immunosuppressive drugs in vitro.
Topics: Aniline Compounds; Animals; Blood; Calcium; CD28 Antigens; Concanavalin A; Crotonates; Cyclosporine; Flow Cytometry; Hydroxybutyrates; Immunosuppressive Agents; Ionomycin; Kinetics; Lymphocyte Activation; Male; Mitogens; Nitriles; Rats; Rats, Inbred Lew; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Toluidines | 2001 |
c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.
Topics: Adenoviridae; Animals; Blotting, Western; Butadienes; Cats; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Detergents; Dose-Response Relationship, Drug; Dual Specificity Phosphatase 1; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Insulin; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; Time Factors | 2002 |
Implication of alpha4 phosphoprotein and the rapamycin-sensitive mammalian target-of-rapamycin pathway in prolactin receptor signalling.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; COS Cells; Humans; Immunosuppressive Agents; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Mice; Molecular Chaperones; Molecular Sequence Data; Phosphoproteins; Phosphorylation; Prolactin; Rats; Receptors, Prolactin; RNA, Messenger; Sequence Alignment; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Flow cytometric detection of intracellular IL-12 release: in vitro effect of widely used immunosuppressants.
Topics: Cyclosporine; Dexamethasone; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-15; Leukocytes, Mononuclear; Lipopolysaccharides; Sirolimus; Tetradecanoylphorbol Acetate | 2002 |
ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.
Topics: Adaptor Proteins, Signal Transducing; Base Sequence; Blotting, Northern; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Cycloheximide; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histidine Decarboxylase; Humans; Hypotonic Solutions; Immediate-Early Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Repressor Proteins; Response Elements; RNA, Messenger; Sirolimus; Tetradecanoylphorbol Acetate; Transcription Factors | 2003 |
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase.
Topics: Androstadienes; Astrocytoma; Calcium Signaling; Carbachol; Chelating Agents; Enzyme Activation; Enzyme Inhibitors; Humans; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Kinase Inhibitors; Protein Kinases; Receptors, Muscarinic; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Wortmannin | 2003 |
Intestinal sugar absorption is regulated by phosphorylation and turnover of protein kinase C betaII mediated by phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent pathways.
Topics: Androstadienes; Animals; Enzyme Inhibitors; Fructose; Glucose Transporter Type 2; Intestinal Absorption; Male; Monosaccharide Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Ubiquitin; Wortmannin | 2003 |
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus.
Topics: Amino Acid Motifs; Animals; Blood Glucose; Blotting, Western; Cell Line; Diabetes Mellitus, Type 2; Glucose; Heterozygote; Humans; Insulin; Insulin Receptor Substrate Proteins; Interleukin-4; Intracellular Signaling Peptides and Proteins; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Serine; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2004 |
Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinases; Cyclins; G1 Phase; Humans; In Vitro Techniques; Ionomycin; Jurkat Cells; Lymphocyte Activation; Macromolecular Substances; Proto-Oncogene Proteins; Sirolimus; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2004 |
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Topics: Brain Neoplasms; Cell Cycle; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2004 |
Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase.
Topics: Antibodies, Monoclonal; Blotting, Western; Butadienes; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Galectin 1; Gene Expression Regulation; Humans; Imidazoles; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; src-Family Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 2004 |
Phorbol 12-myristate 13-acetate and serum synergize to promote rapamycin-insensitive cell proliferation via protein kinase C-eta.
Topics: Blotting, Western; Carcinogens; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; Glioblastoma; Humans; Immunoprecipitation; Immunosuppressive Agents; Oligonucleotides, Antisense; Phosphorylation; Protein Kinase C; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Serum; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2007 |
PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells.
Topics: Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Humans; Leukemia; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinases; Signal Transduction; Sirolimus; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2007 |
Validation of immunological biomarkers for the pharmacodynamic monitoring of immunosuppressive drugs in humans.
Topics: Adult; Antigens, CD; Biomarkers; CD4-Positive T-Lymphocytes; Cell Proliferation; Concanavalin A; Cyclosporine; Drug Monitoring; Humans; Immunosuppressive Agents; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Methylprednisolone; Middle Aged; Mycophenolic Acid; Receptors, Transferrin; Reproducibility of Results; Sirolimus; Tacrolimus; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2007 |
The influence of cyclosporin A on lymphocyte attenuator expression.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Autoimmune Diseases; Carcinogens; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporine; Female; Gene Expression Regulation; Graft Rejection; Immunosuppressive Agents; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Lectins, C-Type; Lymphocyte Activation; Mice; Receptors, Immunologic; Self Tolerance; Sirolimus; Tetradecanoylphorbol Acetate; Transplantation Tolerance | 2007 |
Translational activation of 5'-TOP mRNA in pressure overload myocardium.
Topics: Actins; Analysis of Variance; Animals; Blotting, Western; Cats; Cells, Cultured; Disease Models, Animal; Endothelins; Hypertrophy, Right Ventricular; Insulin; Myocytes, Cardiac; Myosin Heavy Chains; Nonmuscle Myosin Type IIB; Oligopeptides; Phosphorylation; Polyribosomes; Protein Biosynthesis; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; RNA 5' Terminal Oligopyrimidine Sequence; RNA, Messenger; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2008 |
P70 S6 kinase negatively regulates fibroblast growth factor 2-stimulated interleukin-6 synthesis in osteoblasts: function at a point downstream from protein kinase C.
Topics: Animals; Carbazoles; Cells, Cultured; Fibroblast Growth Factor 2; Indoles; Interleukin-6; Maleimides; Mice; Osteoblasts; Phosphorylation; Protein Kinase C; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tetradecanoylphorbol Acetate | 2008 |
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin | 2009 |
Regulation of the autophagic machinery in human neutrophils.
Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hydrogen-Ion Concentration; Inflammation; Microscopy, Confocal; Morpholines; Neutrophils; Phagosomes; Poly I-C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirolimus; Small Ubiquitin-Related Modifier Proteins; Tetradecanoylphorbol Acetate; Toll-Like Receptors; Transcription, Genetic; Vacuoles | 2010 |
Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Blotting, Western; Carcinogens; Humans; Hyperplasia; Mice; Neoplasm Staging; Papilloma; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2011 |
The activation state of the inositol 1,4,5-trisphosphate receptor regulates the velocity of intracellular Ca2+ waves in bovine aortic endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Colforsin; Endothelium, Vascular; Inositol 1,4,5-Trisphosphate Receptors; Protein Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2011 |
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling.
Topics: 3' Untranslated Regions; Animals; Cell Line; Dual Specificity Phosphatase 1; eIF-2 Kinase; ELAV Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gonadotropin-Releasing Hormone; MAP Kinase Signaling System; Mice; Polyribosomes; Protein Biosynthesis; Protein Kinase C; Ribonucleoproteins; RNA, Messenger; Sirolimus; Tetradecanoylphorbol Acetate; Unfolded Protein Response | 2014 |
Metformin inhibits skin tumor promotion in overweight and obese mice.
Topics: Adenylate Kinase; Adiponectin; Animals; Body Weight; Carcinogenesis; Carcinoma, Squamous Cell; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Insulin; Insulin-Like Growth Factor I; Leptin; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Obese; Multiprotein Complexes; Neoplasms, Experimental; Obesity; Overweight; Papilloma; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2014 |
High-throughput screening identifies compounds that enhance lentiviral transduction.
Topics: Animals; Antigens, CD34; Camptothecin; Cell Line, Tumor; Colforsin; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; HEK293 Cells; Hematopoietic Stem Cells; High-Throughput Screening Assays; Humans; Lentivirus; Mice; NIH 3T3 Cells; Sirolimus; Tetradecanoylphorbol Acetate; Transduction, Genetic; U937 Cells | 2014 |
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.
Topics: Breast Neoplasms; Carcinogens; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Drug Interactions; Female; Fibrosarcoma; Humans; MAP Kinase Signaling System; Phosphorylation; Sirolimus; Tetradecanoylphorbol Acetate | 2014 |
Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Fibronectins; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Naphthyridines; Neoplasm Recurrence, Local; Neural Stem Cells; Oncostatin M; Phosphatidylinositol 3-Kinases; Signal Transduction; Sirolimus; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Vimentin | 2017 |
Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway.
Topics: Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; E-Selectin; Gene Knockdown Techniques; Genes, fos; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Lipoproteins, LDL; Mechanistic Target of Rapamycin Complex 2; Protein Kinase C; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; RNA, Small Interfering; Signal Transduction; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate | 2018 |
Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Atrazine; Autophagy; Carps; Extracellular Traps; Glycolysis; Herbicides; Neutrophils; Peroxidase; Reactive Oxygen Species; Sirolimus; Tetradecanoylphorbol Acetate | 2018 |