tetradecanoylphorbol acetate has been researched along with ro 31-8220 in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 84 (66.14) | 18.2507 |
| 2000's | 39 (30.71) | 29.6817 |
| 2010's | 4 (3.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paul, A; Plevin, R; Stewart, A; Wakelam, MJ | 1 |
| Rowe, SJ; Sugden, D | 1 |
| Gilfillan, AM; Lin, P | 1 |
| Boarder, MR; Wilkes, LC | 1 |
| Boarder, MR; Purkiss, JR | 1 |
| Joseph, S; MacDermot, J | 1 |
| Boarder, MR; Challiss, RA | 1 |
| Carew, MA; Paleolog, EM; Pearson, JD | 1 |
| Murphy, CT; Westwick, J | 1 |
| Cook, SJ; Wakelam, MJ | 1 |
| Dieter, P; Fitzke, E | 1 |
| Jones, KT; Sharpe, GR | 1 |
| Greinacher, A; Liebenhoff, U; Presek, P | 1 |
| Carsberg, CJ; Friedmann, PS; Warenius, HM | 1 |
| Keller, HU; Trachsel, S | 1 |
| Greinacher, A; Martinson, EA; Presek, P; Scheible, S | 1 |
| Gould, GW; Graham, A; Malarkey, K; McLees, A; Plevin, R | 1 |
| Backwell, FR; Mackie, SC; Morrison, KS; Palmer, RM; Pascal, M; Thom, A; Thompson, MG | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Briscoe, CP; Cross, M; Martin, A; Wakelam, MJ | 1 |
| Barnes, PJ; Giembycz, MA; Hirst, SJ; Twort, CH; Webb, BL | 1 |
| Volz, A | 1 |
| Exton, JH; Kazlauskas, A; Yeo, EJ | 1 |
| Keller, HU; Niggli, V | 2 |
| Boarder, MR; Purkiss, JR; Wilkinson, GF | 1 |
| Kellock, NA; Plevin, R; Wadsworth, R; Wakelam, MJ | 1 |
| Cordier, J; Glowinski, J; Murphy, NP; Prémont, J | 1 |
| Holden, CM; Mallon, BS; Rumsby, MG; Thompson, HJ; Turner, RA | 1 |
| Graham, A; Russell, LJ | 1 |
| Agius, L; Peak, M | 1 |
| Hawkins, PT; Jackson, TR; Stephens, L | 1 |
| Boarder, MR; Challiss, RA; Patel, V; Purkiss, JR; Wilkes, LC | 1 |
| Hanson, PJ; McKenna, JP | 1 |
| Fenton, JA; Rumsby, MG; Warr, JR | 1 |
| Edwards, SW; Galvani, DW; Lowe, GM; Slupsky, JR | 1 |
| Hinson, JP; Kapas, S | 1 |
| Keller, H; Niggli, V; Zimmermann, A | 1 |
| Purkiss, JR | 1 |
| Boarder, M; Brown, C; Patel, V | 1 |
| Daniels, I; Fletcher, J; Lindsay, MA | 1 |
| Dolci, W; Thorens, B; Widmann, C | 1 |
| Farndale, RW; Hargreaves, PG; Jenner, S; Merritt, JE; Sage, SO | 1 |
| Gnegy, ME; Goldsmith, AM; Shariat-Madar, Z | 1 |
| Hall, N; Kelleher, D; Liskamp, RM; Long, A; O'Connell, MA; O'Neill, LA | 1 |
| Heiskanen, KM; Savolainen, KM | 2 |
| Mackie, SC; Palmer, RM; Thom, A; Thompson, MG | 1 |
| Gobran, LI; Rooney, SA | 1 |
| Doherty, K; Paul, A; Plevin, R | 1 |
| Fraser, C; Morley, S | 1 |
| Mahon, TM; Matthews, JS; O'Neill, LA | 1 |
| Hastings, MH; McNulty, S; McNulty, TJ; Morgan, PJ; Schurov, IL | 1 |
| Grant, DS; Haralabopoulos, GC; Kleinman, HK; Maragoudakis, ME | 1 |
| Fischer, SM; Hagerman, RA; Locniskar, MF | 1 |
| Courage, C; Gescher, A; Hubbard, A; Jones, T | 1 |
| Chan, AC; Choy, PC; Jay, FT; Lee, E; Man, RY; Tran, K; Wong, J | 1 |
| Alonso, A; Auvinen, E; Crusius, K | 1 |
| Engel, K; Gaestel, M; Schultz, H | 1 |
| Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J | 1 |
| Assmann, G; Nofer, JR; Seedorf, U; Tepel, M; Walter, M; Zidek, W | 1 |
| Fey, MF; Macfarlane, DE; Niklaus, G; Pabst, T; Peters, UR; Schwaller, J; Tobler, A | 1 |
| Barrett, P; Davidson, G; Hazlerigg, DG; Morgan, PJ; Morris, MA; Ross, AW | 1 |
| Gnegy, ME; Kantor, L | 1 |
| Light, Y; Marais, R; Marshall, CJ; Mason, C; Olson, MF; Paterson, H | 1 |
| Fischer, T; Mohaupt, MG; Schulze-Lohoff, E; Schwöbel, J; Sterzel, RB | 1 |
| MacGlashan, DW; Miura, K | 1 |
| Hesslinger, C; Hültner, L; Kremmer, E; Ueffing, M; Ziegler, I | 1 |
| Verspohl, EJ; Wienecke, A | 1 |
| Huwiler, A; Kaszkin, M; Pfeilschifter, J; Scholz, K; van den Bosch, H | 1 |
| Guo, YL; Kang, B; Williamson, JR | 1 |
| Chen, BC; Lin, LL; Lin, WW | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Bae, GU; Ha, KS; Han, JW; Hong, S; Kwon, HK; Lee, HW; Lee, HY; Lee, ZW; Seo, DW | 1 |
| Ciampa, MT; Favilla, M; Gazzaniga, PP; Pignatelli, P; Pulcinelli, FM; Riondino, S | 1 |
| Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT | 1 |
| Chang, SH; Lin, WW; Wang, SM | 1 |
| Orie, NN; Tepel, M; Zidek, W | 1 |
| Bronfman, M; Garcia-Huidobro, T; Leisewitz, AV; Valderrama, J; Valenzuela, E | 1 |
| Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T | 1 |
| García-Sáinz, JA; Gottfried-Blackmore, A; Romero-Avila, MT; Vázquez-Prado, J | 1 |
| Ciruela, F; Giacometti, A; McIlhinney, RA | 1 |
| Alcántara-Hernández, R; Gárcia-Sáinz, JA; Vázquez-Prado, J | 1 |
| Lesslauer, W; Mary, JL; Tomás-Zuber, M | 1 |
| Liu, X; Ni, W; Xu, Y; Zhang, Z | 1 |
| Creuzet, C; Dupouy-Camet, J; Robert-Gangneux, F; Roisin, MP | 1 |
| Lin, WW; Wen, HC | 1 |
| Hunziker, IP; Keller, HU; Niggli, V; Sordat, B; Sroka, J | 1 |
| Jang, MA; Kwon, TK; Lee, YH; Park, JW; Passaniti, A | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Avruch, J; Gonçalves, D; Lenz, G; Luo, Z; Neary, JT; Rodnight, R | 1 |
| Aguayo, LG; Albarran, FA; Castillo, R; Navarrete, R; Nualart, F; Roa, JP | 1 |
| Braileanu, GT; Hu, J; Mirando, MA | 1 |
| Chen, JS; Song, JG | 1 |
| Han, C; Lei, B; Zhang, Y | 1 |
| Liu, X; Xu, Y; Zhang, Z | 1 |
| Gauvreau, G; MacGlashan, DW; Miura, K; Saini, SS | 1 |
| Aksoy, MO; Bin, W; Kelsen, SG; Yang, Y; Yun-You, D | 1 |
| Ager, A; Deka, J; Ivetic, A; Ridley, A | 1 |
| Cho, W; Han, JM; Jung, YW; Kim, JH; Kim, Y; Kuroki, T; Lee, BD; Lee, S; Lee, SD; Ohba, M; Ryu, SH; Suh, PG | 1 |
| Ding, Y; Xu, Y; Zhang, Z | 1 |
| Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Maher, P | 1 |
| Flamand, L; Gosselin, J; Savard, M; Tardif, M | 1 |
| Choi, YJ; Kim, YH; Kwon, TK; Lee, JM; Lee, SH; Park, JW; Woo, JH | 1 |
| Fährmann, M; Kaufhold, M; Rieg, T; Seidler, U | 1 |
| Hydén-Granskog, C; Liu, J; Vänttinen, T; Voutilainen, R | 1 |
| Hendry, IA; Ozsarac, N; Reynolds, AJ; Weible, M | 1 |
| Bazuine, M; Bosch, RR; Hermus, AR; Maassen, JA; Olthaar, AJ; Schürmann, A; Span, PN; Sweep, CG; Wake, MM; Willems, PH | 1 |
| Chen, SX; Liu, XS; Ni, W; Xu, YJ; Zhang, ZX | 1 |
| Pacheco, MA; Pastoor, TE; Wecker, L | 1 |
| DeWeese, TL; Eshleman, JR; Nelson, WG; O'Meally, RN; Parker, AR; Racke, FK; Sahin, F; Su, GH | 1 |
| Chen, JS; Exton, JH | 1 |
| Li, F; Shi, J; Song, J; Wang, D; Zhou, Y | 1 |
| Grybko, MJ; Pores-Fernando, AT; Wurth, GA; Zweifach, A | 1 |
| Jerrells, TR; Johnson, JK; Nicolarsen, JR; Pavlik, JA; Sisson, JH; Slager, RE; Wyatt, TA | 1 |
| Chen, YH; Tsai, MC | 1 |
| Das, AK; Dev, S; Fujimoto, K; Fukui, H; Horio, S; Kitamura, Y; Mishima, R; Mizuguchi, H; Takeda, N; Wakayama, Y; Yoshimura, S | 1 |
| Fleischmann, BK; Hescheler, J; Reppel, M; Reuter, H; Sasse, P; Schunkert, H | 1 |
| Chatzaki, E; Haller, H; Kardassis, D; Krasagakis, K; Lindschau, C; Sakellaris, G; Stavroulaki, M; Tosca, A | 1 |
| Hashizume, H; Kamio, N; Matsushima, K; Nakao, S; Sugiya, H | 1 |
| Chou, CC; Hsu, CY | 1 |
| Stricker, SA | 1 |
| Boland, R; Buitrago, C; Costabel, M | 1 |
| Ishiura, S; Koebis, M; Ohno, S; Suo, S; Zhao, Y | 1 |
| Almami, I; Bonner, PL; Dickenson, JM; Hargreaves, AJ | 1 |
| Arias-Montaño, JA; Escamilla-Sánchez, J; García-Hernández, U; Montejo-López, W; Rivera-Ramírez, N | 1 |
127 other study(ies) available for tetradecanoylphorbol acetate and ro 31-8220
| Article | Year |
|---|---|
Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells.
Topics: Animals; Arginine Vasopressin; Glycerophospholipids; Hydrolysis; Indoles; Inositol 1,4,5-Trisphosphate; Mice; Muscle, Smooth, Vascular; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 1992 |
Protein kinase C activation antagonizes melatonin-induced pigment aggregation in Xenopus laevis melanophores.
Topics: Adenosine Monophosphate; Animals; Biological Transport; Cells, Cultured; Cyclic AMP; Cytoplasmic Granules; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Melanocyte-Stimulating Hormones; Melanophores; Melatonin; Pigmentation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides; Xenopus laevis | 1992 |
The role of calcium and protein kinase C in the IgE-dependent activation of phosphatidylcholine-specific phospholipase D in a rat mast (RBL 2H3) cell line.
Topics: Alkaloids; Animals; Calcium; Cell Line; Enzyme Activation; Histamine Release; Immunoglobulin E; Indoles; Ionomycin; Kinetics; Maleimides; Mast Cells; Phospholipase D; Protein Kinase C; Rats; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Evidence for a novel mechanism of activation of phospholipase D by endothelin-1 in neuroblastoma cells.
Topics: Animals; Calcimycin; Endothelins; Enzyme Activation; Indoles; Kinetics; Neuroblastoma; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Purinergic stimulation of phosphatidic acid accumulation is via two pathways in bovine aorta endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Cattle; Cell Line; Endothelium, Vascular; Indoles; Kinetics; Phosphates; Phosphatidic Acids; Phospholipase D; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Thrombin promotes actin polymerization in U937 human monocyte-macrophage cells. Analysis of the signalling mechanisms mediating actin polymerization.
Topics: Actins; Alkaloids; Calcium; Cations, Divalent; Cell Line; Chemotaxis, Leukocyte; GTP-Binding Proteins; Humans; Indoles; Ionomycin; Macrophages; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Polymers; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1992 |
Role of protein kinase C in the regulation of histamine and bradykinin stimulated inositol polyphosphate turnover in adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Bradykinin; Cattle; Cells, Cultured; Histamine; Indoles; Inositol Phosphates; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
The roles of protein kinase C and intracellular Ca2+ in the secretion of von Willebrand factor from human vascular endothelial cells.
Topics: Adenosine Triphosphate; Alkaloids; Calcimycin; Calcium; Cations, Divalent; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Humans; Indoles; Maleimides; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; von Willebrand Factor | 1992 |
Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses.
Topics: Animals; Blood Platelets; Calcium; Enzyme Activation; Indoles; Kinetics; Maleimides; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Rabbits; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1992 |
Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis.
Topics: 3T3 Cells; Animals; Bombesin; Catalysis; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Glycerophospholipids; Indoles; Inositol Phosphates; Mice; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages.
Topics: Alkaloids; Animals; Cells, Cultured; Dinoprostone; Indoles; Kinetics; Macrophages; Maleimides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Staurosporine, a non-specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31-8220, a specific inhibitor, does not.
Topics: Alkaloids; Calcium; Cell Differentiation; Cell Division; Humans; Indoles; Intracellular Membranes; Keratinocytes; Protein Kinase C; Protein Precursors; Staining and Labeling; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
The protein tyrosine kinase pp60c-src is activated upon platelet stimulation.
Topics: Arginine Vasopressin; Blood Platelets; Collagen; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Tetradecanoylphorbol Acetate | 1994 |
Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Diglycerides; Enzyme Induction; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Signal Transduction; Skin Neoplasms; Taurodeoxycholic Acid; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1994 |
Selective responses (actin polymerization, shape changes, locomotion, pinocytosis) to the PKC inhibitor Ro 31-8220 suggest that PKC discriminately regulates functions of human blood lymphocytes.
Topics: Actins; Cell Movement; Cell Size; Dextrans; Fluorescein-5-isothiocyanate; Humans; Indoles; Lymphocytes; Pinocytosis; Polymers; Protein Kinase C; Tetradecanoylphorbol Acetate | 1995 |
Platelet phospholipase D is activated by protein kinase C via an integrin alpha IIb beta 3-independent mechanism.
Topics: Amino Acid Sequence; Blood Platelets; Calcimycin; Collagen; Enzyme Activation; Humans; Indoles; Integrins; Kinetics; Oligopeptides; Phospholipase D; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Receptors, Cytoadhesin; Tetradecanoylphorbol Acetate; Thrombin | 1995 |
Regulation of lysophosphatidic acid-stimulated tyrosine phosphorylation of pp42 mitogen-activated protein kinase by protein kinase C and protein kinase A in EAhy926 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Indoles; Isoenzymes; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Evidence that protein kinase C and mitogen activated protein kinase are not involved in the mechanism by which insulin stimulates translation in L6 myoblasts.
Topics: Amino Acid Sequence; Animals; Antifungal Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclooxygenase Inhibitors; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Ibuprofen; Indoles; Insulin; Molecular Sequence Data; Muscle Fibers, Skeletal; Polyenes; Protein Biosynthesis; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Bombesin; Genistein; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Isoflavones; Kinetics; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 1995 |
Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase.
Topics: Animals; Asthma; Cell Division; Cells, Cultured; Cinnamates; Culture Media; Disease Models, Animal; DNA; Humans; Indoles; Maleimides; Muscle, Smooth; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Sulfides; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Regulation of CD18 expression in human neutrophils as related to shape changes.
Topics: Amino Acid Sequence; Antigens, CD; CD18 Antigens; Cell Movement; Cell Size; Chemotactic Factors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Marine Toxins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oligopeptides; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate | 1993 |
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.
Topics: Animals; Binding Sites; Cell Line; Dogs; Enzyme Activation; Indoles; Inositol Phosphates; Isoenzymes; Kidney; Kinetics; Mutagenesis, Site-Directed; Myristic Acid; Myristic Acids; Phospholipase D; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Point Mutation; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 1994 |
Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41,251 on PMN locomotion, cell polarity, and pinocytosis.
Topics: Alkaloids; Amino Acid Sequence; Cell Movement; Cell Polarity; Cell Size; Chemotaxis, Leukocyte; Humans; In Vitro Techniques; Indoles; Molecular Sequence Data; Molecular Weight; Neutrophils; Oligopeptides; Phosphoproteins; Pinocytosis; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Differential regulation of inositol 1,4,5-trisphosphate by co-existing P2Y-purinoceptors and nucleotide receptors on bovine aortic endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Indoles; Inositol 1,4,5-Trisphosphate; Nucleotides; Protein Kinase C; Purines; Receptors, Purinergic; Second Messenger Systems; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors; Uridine Triphosphate | 1994 |
Regulation by hypoxia of endothelin-1-stimulated phospholipase D activity in sheep pulmonary artery cultured smooth muscle cells.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Endothelins; Glycerophospholipids; Hypoxia; Indoles; Inositol Phosphates; Molecular Sequence Data; Muscle, Smooth, Vascular; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Pulmonary Artery; Serotonin; Sheep; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
Is protein kinase C activity required for the N-methyl-D-aspartate-evoked rise in cytosolic Ca2+ in mouse striatal neurons?
Topics: Alkaloids; Animals; Biological Transport; Calcium; Corpus Striatum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indoles; Mice; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium Chloride; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Protein kinase C activation of phospholipase D in C6 glioma cells.
Topics: Alkaloids; Animals; Cell Line; Enzyme Activation; Glioma; Indoles; Phorbol Esters; Phospholipase D; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Stimulation of low-density lipoprotein uptake in HepG2 cells by epidermal growth factor via a tyrosine kinase-dependent, but protein kinase C-independent, mechanism.
Topics: Acetates; Cholesterol; Enzyme Activation; Epidermal Growth Factor; Esterification; Genistein; Humans; Indoles; Isoflavones; Lipoproteins, LDL; Protein Kinase C; Protein-Tyrosine Kinases; Sucrose; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins.
Topics: Animals; Calcium; Cell Count; Cells, Cultured; Cytochalasin D; Epidermal Growth Factor; Glucose; Glycogen; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Lactates; Lactic Acid; Liver; Male; Pertussis Toxin; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues.
Topics: Cell Membrane Permeability; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; Indoles; Inositol; Inositol Phosphates; Kinetics; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphates; Phosphatidylinositol Phosphates; Phosphorus Radioisotopes; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Phospholipase D activation regulates endothelin-1 stimulation of phosphoinositide-specific phospholipase C in SK-N-MC cells.
Topics: Butanols; Endothelins; Enzyme Activation; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1993 |
The PKC-inhibitor Ro 31-8220 selectively suppresses PMA- and diacylglycerol-induced fluid pinocytosis and actin polymerization in PMNs.
Topics: Actins; Cytochalasin D; Diglycerides; Dose-Response Relationship, Drug; Humans; Indoles; Neutrophils; Oligopeptides; Pinocytosis; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells.
Topics: Aminopyrine; Animals; Carbachol; Cells, Cultured; Enzyme Activation; Gastric Acid; Histamine; Indoles; Parietal Cells, Gastric; Protein Kinase C; Rats; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
The relationship between protein kinase C subspecies and multidrug resistance in vincristine resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; CHO Cells; Choline; Cricetinae; Drug Resistance, Multiple; Indoles; Isoenzymes; Kinetics; Phospholipids; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Vincristine | 1995 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
Inhibition of endothelin- and phorbol ester-stimulated tyrosine kinase activity by corticotrophin in the rat adrenal zona glomerulosa.
Topics: Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Cyclic AMP; Endothelins; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Indoles; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1996 |
Inhibition of protein kinase C-dependent protein phosphorylation correlates with increased polarity and locomotion in Walker 256 carcinosarcoma cells.
Topics: Animals; Carcinoma 256, Walker; Cell Movement; Cell Polarity; Humans; Indoles; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Protein kinase C modulation of phosphoinositidase C in 1321N1 human astrocytoma cells.
Topics: Astrocytoma; Butanols; Cell Line; Enzyme Inhibitors; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Kinetics; Phospholipase D; Phosphoric Diester Hydrolases; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Protein kinase C isoforms in endothelial cells: role in agonist stimulated prostacyclin release.
Topics: Adenosine Triphosphate; Animals; Cattle; Cell Membrane; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Indoles; Isoenzymes; Kinetics; Protein Kinase C; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate; Thionucleotides; Uridine Triphosphate | 1996 |
Investigation of the role of protein kinase C and tyrosine kinases during the rapid and sustained release of superoxide from adherent human neutrophils.
Topics: Cell Adhesion; Cinnamates; Enzyme Inhibitors; Humans; Indoles; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Neutrophils; Phenols; Protein Kinase C; Protein-Tyrosine Kinases; Sulfides; Superoxides; Tetradecanoylphorbol Acetate | 1996 |
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Ionomycin-stimulated arachidonic acid release in human platelets: a role for protein kinase C and tyrosine phosphorylation.
Topics: Arachidonic Acid; Blood Platelets; Calcium; Collagen; Enzyme Inhibitors; Genistein; Humans; Indoles; Ionomycin; Ionophores; Isoflavones; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
Effect of continuous phorbol ester treatment on muscarinic receptor-mediated calmodulin redistribution in SK-N-SH neuroblastoma cells.
Topics: Calmodulin; Carbachol; Cytosol; Enzyme Inhibitors; Humans; Immunoblotting; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C; Proteins; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tissue Distribution; Tretinoin; Tumor Cells, Cultured | 1997 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Palmitic acid anilide-induced respiratory burst in human polymorphonuclear leukocytes is inhibited by a protein kinase C inhibitor, Ro 31-8220.
Topics: Adult; Anilides; Calcium; Enzyme Inhibitors; Humans; Indoles; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Palmitic Acids; Protein Kinase C; Reactive Oxygen Species; Respiratory Burst; Tetradecanoylphorbol Acetate | 1997 |
Regulation of phospholipase D in L6 skeletal muscle myoblasts. Role of protein kinase c and relationship to protein synthesis.
Topics: Analysis of Variance; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Gene Expression Regulation, Enzymologic; Indoles; Kinetics; Muscle, Skeletal; Phospholipase D; Protein Biosynthesis; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic; Vasopressins | 1997 |
Influence of the protein kinase C inhibitor 3-[1-[3-(amidinothio) propyl]-1H-indoyl-3-yl]-3-(1-methyl-1H-indoyl-3-yl) maleimide methane sulfonate (Ro-318220) on surfactant secretion in type II pneumocytes.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Enzyme Inhibitors; Indoles; Lung; Male; Phosphatidylcholines; Protein Kinase C; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1997 |
Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Muscle, Smooth, Vascular; Naphthalenes; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Studies on the phosphorylation of eIF4E in Xenopus (XIK-2) kidney cells.
Topics: Animals; Cell Line; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Immunosuppressive Agents; Indoles; Kidney; Kinetics; Peptide Initiation Factors; Phosphorylation; Polyenes; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate; Xenopus | 1997 |
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
Topics: Animals; Cell Membrane; Cytosol; Drug Synergism; Enzyme Inhibitors; Indoles; Interleukin-1; Interleukin-2; Isoenzymes; Kinetics; Mice; NF-kappa B; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Time Factors; Tumor Cells, Cultured | 1997 |
Melatonin-sensitive, serum-stimulated signalling in ovine pars tuberalis.
Topics: Animals; Blood; Cells, Cultured; Colforsin; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Female; Fluorescent Dyes; Fura-2; Genes, Immediate-Early; Immunoenzyme Techniques; Indoles; Male; Melatonin; Phosphorylation; Pituitary Gland, Anterior; Protein Kinase C; Proto-Oncogene Proteins c-fos; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors | 1997 |
Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo.
Topics: Animals; Basement Membrane; Biocompatible Materials; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Down-Regulation; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Indoles; Laminin; Mice; Mice, Inbred C57BL; Models, Cardiovascular; Neovascularization, Physiologic; Protein Kinase C; Proteoglycans; Receptors, Thrombin; Signal Transduction; Skin; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1997 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on inhibition of expression of keratin 1 mRNA in mouse keratinocytes mimicked by 12(S)-hydroxyeicosatetraenoic acid.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Blotting, Western; Bryostatins; Carcinogens; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Keratinocytes; Keratins; Lactones; Macrolides; Mice; Mice, Inbred SENCAR; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA, Messenger; Tetradecanoylphorbol Acetate | 1997 |
Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues.
Topics: Alkaloids; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Isoenzymes; Maleimides; Microscopy, Confocal; Models, Chemical; Protein Kinase C; Protein Kinase C-theta; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Fingers | 1997 |
Vitamin E (alpha-tocopherol) enhances arachidonic acid release in rat heart myoblastic cells through the activation of cytosolic phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Cytosol; Enzyme Activation; Enzyme Inhibitors; Heart; Indoles; Ionophores; Isoenzymes; Muscle Proteins; Myocardium; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Vitamin E | 1997 |
Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Indoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oncogene Proteins, Viral; Open Reading Frames; Papillomaviridae; Protein Kinase C; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1997 |
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate | 1997 |
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1997 |
Phosphatidylcholine-specific phospholipase C regulates thapsigargin-induced calcium influx in human lymphocytes.
Topics: Bridged-Ring Compounds; Butanols; Calcium; Enzyme Inhibitors; Estrenes; Humans; Indoles; Lymphocytes; Nickel; Norbornanes; Phosphatidylcholines; Phosphatidylinositols; Propranolol; Pyrrolidinones; Tetradecanoylphorbol Acetate; Thapsigargin; Thiocarbamates; Thiones; Type C Phospholipases | 1997 |
Up-regulation of p21WAF1 expression in myeloid cells is activated by the protein kinase C pathway.
Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Indoles; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; Up-Regulation | 1997 |
Mel 1a melatonin receptor expression is regulated by protein kinase C and an additional pathway addressed by the protein kinase C inhibitor Ro 31-8220 in ovine pars tuberalis cells.
Topics: Animals; Enzyme Inhibitors; Female; Gene Expression Regulation; Indoles; Male; Pituitary Gland, Anterior; Protein Kinase C; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sheep; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices.
Topics: Alkaloids; Amphetamine; Animals; Benzophenanthridines; Biological Transport; Calcium; Corpus Striatum; Dopamine; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Naphthalenes; Phenanthridines; Protein Kinase C; Rats; Reserpine; Tetradecanoylphorbol Acetate | 1998 |
Erucic acid and erucic acid anilide-induced oxidative burst in human polymorphonuclear leukocytes.
Topics: Anilides; Calcium; Dose-Response Relationship, Drug; Erucic Acids; Humans; Indoles; Intracellular Fluid; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Reactive Oxygen Species; Respiratory Burst; Tetradecanoylphorbol Acetate | 1997 |
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Guanosine Triphosphate; Indoles; Mutation; Protein Kinase C; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor, Muscarinic M1; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Indoles; Interferon-gamma; Lipopolysaccharides; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1998 |
Expression of protein kinase C isozymes in human basophils: regulation by physiological and nonphysiological stimuli.
Topics: Antibodies, Anti-Idiotypic; Basophils; Biological Transport; Calcium; Carbazoles; Cell Membrane; Cells, Cultured; Enzyme Induction; Enzyme Inhibitors; Histamine Release; Humans; Indoles; Ionomycin; Ionophores; Isoenzymes; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Naphthalenes; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells. GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C.
Topics: Animals; Biopterins; Casein Kinase II; Cells, Cultured; Enzyme Inhibitors; GTP Cyclohydrolase; Indoles; Isoenzymes; Mast Cells; Mice; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Receptors, IgE; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
The role of protein kinase C in the desensitization of rat pancreatic islets to cholinergic stimulation.
Topics: Analysis of Variance; Animals; Carbachol; Enzyme Inhibitors; Female; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscarinic Agonists; Peptide Fragments; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1998 |
Negative regulation of interleukin-1beta-activated neutral sphingomyelinase by protein kinase C in rat mesangial cells.
Topics: Animals; Cells, Cultured; Ceramides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Indoles; Interleukin-1; Isoenzymes; Phosphorylcholine; Protein Kinase C; Rats; Signal Transduction; Sphingomyelin Phosphodiesterase; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Resistance to TNF-alpha cytotoxicity can be achieved through different signaling pathways in rat mesangial cells.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cells, Cultured; Cycloheximide; Drug Resistance; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Immediate-Early Proteins; Indoles; JNK Mitogen-Activated Protein Kinases; Male; Maleimides; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
Hydrogen peroxide activates p70(S6k) signaling pathway.
Topics: Androstadienes; Animals; Calcium; Catalase; Cell Line; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Indoles; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Concomitant activation of Gi protein-coupled receptor and protein kinase C or phospholipase C is required for platelet aggregation.
Topics: Adenosine Diphosphate; Aspirin; Chelating Agents; Crotalid Venoms; Egtazic Acid; Enzyme Activation; Epinephrine; GTP-Binding Proteins; Humans; Indoles; Lectins, C-Type; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alprostadil; Animals; Calcium; Cell Line; Cholera Toxin; Colchicine; Colforsin; Cyclic AMP; Cytochalasin B; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; GTP-Binding Proteins; Indoles; Isoenzymes; Isoproterenol; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
Tyrosine and calcium/calmodulin kinases are common signaling components in the generation of reactive oxygen species in human lymphocytes.
Topics: Aminoquinolines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catalase; Cinnamates; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Lymphocyte Activation; Lymphocytes; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Protein-Tyrosine Kinases; Reactive Oxygen Species; Signal Transduction; Sodium Azide; Sulfides; Tetradecanoylphorbol Acetate; Tyrphostins | 1999 |
Anti-proliferative effect of two novel palmitoyl-carnitine analogs, selective inhibitors of protein kinase C conventional isoenzymes.
Topics: Animals; Antineoplastic Agents; Brain; Carnitine; Cell Differentiation; Drug Design; Enzyme Inhibitors; HL-60 Cells; Humans; In Vitro Techniques; Indoles; Isoenzymes; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1999 |
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells.
Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1999 |
Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors.
Topics: Animals; Binding, Competitive; Calcium; Cell Line; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Inositol Phosphates; Membranes; Norepinephrine; Phentolamine; Phosphorylation; Piperazines; Prazosin; Precipitin Tests; Protein Kinase C; Radioligand Assay; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Functional regulation of metabotropic glutamate receptor type 1c: a role for phosphorylation in the desensitization of the receptor.
Topics: Animals; Biotinylation; CHO Cells; Cricetinae; Enzyme Inhibitors; Indoles; Inositol Phosphates; Kinetics; Membrane Proteins; Phosphorylation; Protein Conformation; Protein Kinase C; Quisqualic Acid; Receptors, Metabotropic Glutamate; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1999 |
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Pyrans; Pyrethrins; Rats; Receptors, Adrenergic, alpha-1; Spiro Compounds; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
Topics: Amino Acid Sequence; Catalytic Domain; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Indoles; Insulin; Ionomycin; Isoquinolines; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha | 2000 |
The regulating effects of protein kinase C on the tone of guinea-pig trachea and human lobus bronchi.
Topics: Animals; Bronchi; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Protein Kinase C; Species Specificity; Tetradecanoylphorbol Acetate; Trachea | 1998 |
Involvement of the mitogen-activated protein (MAP) kinase signalling pathway in host cell invasion by Toxoplasma gondii.
Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Mitogen-Activated Protein Kinases; Models, Biological; Signal Transduction; Tetradecanoylphorbol Acetate; Toxoplasma | 2000 |
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
Topics: Acetophenones; Arachidonic Acid; Benzopyrans; Calcium; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Protein kinase C isoforms involved in regulation of cell shape and locomotion of human fibrosarcoma HT1080 cells.
Topics: Carbazoles; Cell Membrane; Cell Movement; Cell Size; Cytosol; Enzyme Inhibitors; Fibrosarcoma; Humans; Indoles; Isoenzymes; Kinetics; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 2000 |
p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization.
Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Humans; Indoles; Kinetics; Luciferases; Maleimides; Okadaic Acid; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Suppressor Protein p53; U937 Cells | 2001 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indoles; Kinetics; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Norepinephrine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Rats; Serotonin; Tetradecanoylphorbol Acetate | 2001 |
Effect of protein kinase C activation on the glycine evoked Cl(-) current in spinal cord neurons.
Topics: Animals; Cells, Cultured; Chloride Channels; Chlorides; Enzyme Activation; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; Glycine; Indoles; Ion Transport; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Protein Kinase C; Receptors, Glycine; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 2001 |
Oxytocin stimulates prostaglandin F2alpha secretion from porcine endometrial cells through activation of calcium-dependent protein kinase C.
Topics: Animals; Calcium; Carbazoles; Dinoprost; Drug Synergism; Endometrium; Enzyme Activation; Enzyme Inhibitors; Female; Indoles; Inositol Phosphates; L-Lactate Dehydrogenase; Male; Oxytocin; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate; Thapsigargin | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Sustained norepinephrine stimulation induces different regulation of expression in three alpha1-adrenoceptor subtypes.
Topics: Cell Line; Egtazic Acid; Genistein; Humans; Indoles; Kidney; Norepinephrine; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection; Tyrphostins | 2001 |
[The regulating effect of protein kinase C pathway on the airway tone].
Topics: Animals; Asthma; Guinea Pigs; Indoles; Lung; Male; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Protein Kinase C; Random Allocation; Tetradecanoylphorbol Acetate; Trachea | 1998 |
Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils.
Topics: Adjuvants, Immunologic; Basophils; Calcium; Cell Survival; Complement C5a; DNA-Binding Proteins; Humans; Indoles; Interleukin-3; Interleukin-5; Intracellular Fluid; Janus Kinase 2; Leukotriene C4; MAP Kinase Signaling System; Milk Proteins; Nerve Growth Factor; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptors, IgE; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Trans-Activators | 2001 |
Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells.
Topics: Cell Line; Enzyme Inhibitors; Epithelial Cells; Genes, Reporter; Humans; Indoles; Interleukin-1; Leupeptins; Naphthalenes; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; Receptors, Adrenergic, beta-2; Respiratory Mucosa; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Up-Regulation | 2001 |
The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin.
Topics: Amino Acid Sequence; Animals; Chromatography, Affinity; Cytoplasm; Cytoskeletal Proteins; Enzyme Inhibitors; Humans; Indoles; L-Selectin; Lymphocytes; Mice; Mice, Inbred BALB C; Microfilament Proteins; Molecular Sequence Data; Neurofibromin 2; Phosphoproteins; Protein Binding; Protein Kinase C; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate | 2002 |
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells.
Topics: Acetophenones; Adenoviridae; Animals; Benzopyrans; Bradykinin; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunoblotting; Immunohistochemistry; Indoles; Isoenzymes; Maleimides; Microscopy, Fluorescence; Mutation; PC12 Cells; Peptide Mapping; Phospholipase D; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Rats; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 2002 |
[A study of the effect of protein kinase C on the expression of nitric oxide synthase mRNA in pulmonary artery smooth muscle in hypoxia].
Topics: Animals; Arginine; Cell Hypoxia; Cells, Cultured; Enzyme Inhibitors; Gene Expression; Indoles; Isoenzymes; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxygen; Protein Kinase C; Protein Kinase C-alpha; Pulmonary Artery; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.
Topics: Adenosine Diphosphate; Androstadienes; Calcimycin; Calcium Signaling; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Indoles; Ionophores; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxanes; Type C Phospholipases; Wortmannin | 2001 |
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes.
Topics: Cell Membrane; Cytosol; DNA-Binding Proteins; Enzyme Inhibitors; Herpesvirus 4, Human; Humans; Indoles; Monocytes; Naphthalenes; Phagocytosis; Protein Kinase C; Protein Transport; Tetradecanoylphorbol Acetate; Trans-Activators; Viral Proteins | 2002 |
Failure to activate caspase 3 in phorbol ester-resistant leukemia cells is associated with resistance to apoptotic cell death.
Topics: Apoptosis; Caspase 3; Caspases; Cell Nucleus; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Protein Kinase C; Tetradecanoylphorbol Acetate; U937 Cells | 2002 |
Different actions of protein kinase C isoforms alpha and epsilon on gastric acid secretion.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Cells, Cultured; Enzyme Activators; Gastric Acid; In Vitro Techniques; Indoles; Male; Parietal Cells, Gastric; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rabbits; Tetradecanoylphorbol Acetate | 2002 |
Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells.
Topics: Bucladesine; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Follistatin-Related Proteins; Gene Expression Regulation; Humans; Indoles; Luteal Cells; Luteinizing Hormone; Ovary; Progesterone; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2002 |
Activation of protein kinase C inhibits retrograde transport of neurotrophins in mice.
Topics: Actin Cytoskeleton; Animals; Axonal Transport; Cell Survival; Enzyme Activators; Enzyme Inhibitors; Eye; Growth Cones; Indoles; Male; Mice; Mice, Inbred BALB C; Nerve Growth Factors; Neurons, Afferent; Presynaptic Terminals; Protein Kinase C; Receptor, Nerve Growth Factor; Receptor, trkA; Superior Cervical Ganglion; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Trigeminal Ganglion | 2003 |
Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Indoles; Isoenzymes; Mice; Molecular Mimicry; Monosaccharide Transport Proteins; Muscle Proteins; Oligopeptides; Peptides; Protein Kinase C; Protein Kinase C beta; Staurosporine; Tetradecanoylphorbol Acetate | 2003 |
[Effect of protein kinase C on K(V) channel in rat bronchial smooth muscle].
Topics: Animals; Bronchi; Cells, Cultured; Female; Indoles; Kv1.5 Potassium Channel; Male; Membrane Potentials; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate | 2003 |
Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Carcinogens; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Neurons; Phosphorylation; Protein Kinase C; Receptors, Nicotinic; Sulfonamides; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection | 2003 |
Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
Topics: Adenine; Adjuvants, Immunologic; Alleles; Amino Acid Sequence; Base Pair Mismatch; Carcinogens; Casein Kinase II; Cell Line, Tumor; Chromatography, Liquid; Colorectal Neoplasms; Cyclic AMP-Dependent Protein Kinases; Cytosine; DNA Damage; DNA Glycosylases; DNA Repair; Guanosine; Humans; Immunoblotting; Indoles; Maleimides; Microsatellite Repeats; Molecular Sequence Data; Phosphorylation; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Serine; Software; Tetradecanoylphorbol Acetate; Up-Regulation | 2003 |
Regulation of phospholipase D2 activity by protein kinase C alpha.
Topics: Animals; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genetic Vectors; Indoles; Maleimides; Phospholipase D; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Serine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Threonine; Time Factors; Transfection | 2004 |
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Topics: 3T3-L1 Cells; Acetophenones; Adipocytes; Adipogenesis; Animals; Benzopyrans; Carbazoles; Cell Differentiation; Cell Membrane; Cell Proliferation; Chromans; Cytosol; Epidermal Growth Factor; Gene Expression; Genes, Dominant; Indoles; Mice; Mutant Proteins; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Transport; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2006 |
Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
Topics: Acetophenones; Benzopyrans; Calcium; Carbazoles; Cell Line, Tumor; Cell Membrane; Cytotoxicity, Immunologic; Exocytosis; Humans; Indoles; Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 2007 |
Inhibition of protein kinase C epsilon causes ciliated bovine bronchial cell detachment.
Topics: Animals; Bronchi; Carcinogens; Cattle; Cell Adhesion; Cells, Cultured; Cilia; Enzyme Activation; Enzyme Inhibitors; Indoles; Naphthalenes; Protein Kinase C-epsilon; Respiratory Mucosa; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
(+/-)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron.
Topics: Action Potentials; Alkaloids; Animals; Benzophenanthridines; Calcium; Carbazoles; Electrophysiology; Enzyme Inhibitors; Estrenes; Ganglia, Invertebrate; Hallucinogens; In Vitro Techniques; Indoles; Isoquinolines; Magnesium; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrroles; Pyrrolidinones; Snails; Sulfonamides; Tetradecanoylphorbol Acetate | 2007 |
Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cyclic GMP; Enzyme Inhibitors; HeLa Cells; Histamine; Histamine H1 Antagonists; Humans; Indoles; Luciferases; Protein Kinase C; Pyrilamine; Pyrroles; Receptors, Histamine H1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thionucleotides; Transcription, Genetic; Transfection; Tritium; Up-Regulation | 2007 |
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Animals; Carbazoles; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Fetal Development; Gestational Age; Heart; Heart Ventricles; Indoles; Mice; Myocytes, Cardiac; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Pyrroles; Sodium-Calcium Exchanger; Tetradecanoylphorbol Acetate | 2007 |
Exposure of normal human melanocytes to a tumor promoting phorbol ester reverses growth suppression by transforming growth factor beta.
Topics: Apoptosis Regulatory Proteins; Carcinogens; Cell Culture Techniques; Cell Proliferation; Culture Media, Serum-Free; Enzyme Inhibitors; Genes, Reporter; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Kinetics; Luciferases; Male; Melanocytes; Mitochondrial Proteins; Oligonucleotides, Antisense; Protein Kinase C-alpha; Recombinant Proteins; Signal Transduction; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Transforming Growth Factor beta1 | 2008 |
Protein kinase C synergistically stimulates tumor necrosis factor-alpha-induced secretion of urokinase-type plasminogen activator in human dental pulp cells.
Topics: Carcinogens; Cells, Cultured; Culture Media, Conditioned; Dental Pulp; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Indoles; Molar; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Urokinase-Type Plasminogen Activator | 2008 |
Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Differentiation; Erythroid Cells; Hemin; Humans; Indoles; K562 Cells; Maleimides; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase C beta; Tetradecanoylphorbol Acetate | 2009 |
Roles of protein kinase C isotypes during seawater-versus cAMP-induced oocyte maturation in a marine worm.
Topics: Animals; Bridged-Ring Compounds; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunoblotting; Indoles; Invertebrates; Isoenzymes; Maleimides; Neomycin; Norbornanes; Oocytes; Protein Kinase C; Seawater; Signal Transduction; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 2009 |
PKC and PTPα participate in Src activation by 1α,25OH2 vitamin D3 in C2C12 skeletal muscle cells.
Topics: Animals; Calcitriol; Cell Line, Tumor; Computer Simulation; Enzyme Activation; Indoles; MAP Kinase Signaling System; Mice; Models, Molecular; Muscle Fibers, Skeletal; Phosphorylation; Protein Binding; Protein Kinase C; Protein Transport; Receptor-Like Protein Tyrosine Phosphatases, Class 4; src-Family Kinases; Tetradecanoylphorbol Acetate; Thermodynamics | 2011 |
Regulation of the alternative splicing of sarcoplasmic reticulum Ca²⁺-ATPase1 (SERCA1) by phorbol 12-myristate 13-acetate (PMA) via a PKC pathway.
Topics: Alternative Splicing; Exons; HEK293 Cells; Humans; Indoles; Myotonic Dystrophy; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Kinase Inhibitors; RNA Interference; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Tetradecanoylphorbol Acetate | 2012 |
Modulation of transglutaminase 2 activity in H9c2 cells by PKC and PKA signalling: a role for transglutaminase 2 in cytoprotection.
Topics: Animals; Carbazoles; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; GTP-Binding Proteins; Indoles; Protein Glutamine gamma Glutamyltransferase 2; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Transglutaminases | 2014 |
Heterologous, PKC-Mediated Desensitization of Human Histamine H3 Receptors Expressed in CHO-K1 Cells.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cell Membrane; CHO Cells; Colforsin; Cricetulus; Humans; Indoles; Phosphorylation; Protein Kinase C; Receptors, Histamine H3; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |