Page last updated: 2024-08-23

tetradecanoylphorbol acetate and pd 98059

tetradecanoylphorbol acetate has been researched along with pd 98059 in 234 studies

Research

Studies (234)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's85 (36.32)18.2507
2000's133 (56.84)29.6817
2010's16 (6.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Claus, R; Deigner, HP1
Giasson, E; Meloche, S; Servant, MJ1
Creedon, DJ; Johnson, EM; Lawrence, JC1
Abraham, ST; Baker, KM; Bhat, GJ1
Hu, E; Kim, JB; Sarraf, P; Spiegelman, BM1
Ho, DT; Murphy, TH; Shayan, H1
Bellosillo, B; Gil, J; Joaquin, M; Lange, AJ; Salvado, C; Tauler, A1
Cybulsky, AV; McTavish, AJ1
Ao, L; Berl, T; Butterfield, LM; Heasley, LE; Siriwardana, G1
Evans, J; Posada, J; Whelchel, A1
Fraser, C; Morley, S1
Atkins, KB; Simpson, RU; Somerman, MJ1
Cox, ME; Parsons, SJ1
Goldfarb, AN; Goueli, S; Lewandowska, K; Racke, FK1
Häussinger, D; Kurz, AK; Schliess, F; vom Dahl, S1
Stepan, VM; Takeuchi, Y; Todisco, A; Urumov, A; Yamada, J; Yamada, T1
Engel, K; Gaestel, M; Schultz, H1
Anderson, WH; Crilly, KS; Kiss, Z1
Pyne, NJ; Pyne, S; Tolan, D1
Alblas, J; Dufourny, B; Steenbergh, PH; Sussenbach, JS; van der Burg, B; van Schaik, FM; van Teeffelen, HA1
Chambers, TC; Cloud-Heflin, BA; Kumar, A; Mehta, KD1
Beale, G; Mallon, B; Morreale, A; Rumsby, M; Watson, J1
Eckberg, WR1
Almazan, G; Larocca, JN1
Belfrage, P; Degerman, E; Landström, TR; Manganiello, V; Wijkander, J1
Avruch, J; Caudwell, FB; Cohen, P; Dalby, KN; Morrice, N1
Alblas, J; Slager-Davidov, R; Steenbergh, PH; Sussenbach, JS; van der Burg, B1
Baker, KM; Bhat, GJ; Hunt, RA1
Decker, S; Herrera, R; Hubbell, S; Petruzzelli, L1
Camacho, R; DaSilva, C; Dumont, FJ; Fischer, P; Staruch, MJ1
Herrera, R1
Boyd, D; Goepfert, H; Simon, C1
Bhardwaj, D; Eyster, KM; Mijovic, JE; Olson, DM; Zakar, T1
Barrett, P; Morgan, PJ; Ross, AW; Thompson, M; Webster, CA1
Kucera, GL; Stadheim, TA1
Baines, IA; Cooper, JA; Flynn, A; Proud, CG; Vries, RG; Wang, X; Waskiewicz, AJ; Webb, BL1
Ballotti, R; Bertolotto, C; Brunet, A; Buscà, R; Englaro, W; Ortonne, JP; Pagès, G1
de Jonge, HR; Dorrestijn, J; Maassen, JA; Narumiya, S; Tilly, BC; van der Wijk, T1
Linder, S; Ljungdahl, S; Shoshan, MC; Swedenborg, J; Zhou, JN1
Askari, A; Gnudi, L; Kahn, BB; Kometiani, P; Li, J; Xie, Z1
Greene, RM; Lloyd, MR; Potchinsky, MB; Weston, WM1
Copeland, RA; Daulerio, AJ; Earl, RA; Favata, MF; Feeser, WS; Hobbs, F; Horiuchi, KY; Magolda, RL; Manos, EJ; Pitts, WJ; Scherle, PA; Stradley, DA; Trzaskos, JM; Van Dyk, DE1
Allgayer, H; Boyd, D; Gum, R; Juarez, J; Mazar, A; Wang, Y1
Delling, M; Gercken, G; Marti, T; Radloff, M1
Cook, JA; Durando, MM; Meier, KE1
Ivashkiv, LB; Scherle, PA; Sengupta, TK; Talbot, ES1
André, F; Daemi, N; Lehmann, M; Luis, J; Marvaldi, J; Rigot, V1
Edwards, YS; Murray, AW; Nicholas, TE; Power, JH; Sutherland, LM1
Du, X; Guo, Z; Iacovitti, L1
Linch, DC; Mollapour, E; Roberts, PJ; Watts, MJ1
Nagarkatti, DS; Sha'afi, RI1
Abebe, B; Azzoni, L; Eisenlohr, LC; Paroli, M; Perussia, B; Puorro, KA; Trotta, R1
Boulay, F; Christophe, T; Milcent, MD; Rabiet, MJ; Tardif, M1
Bieszczad, CK; Craig, RW; Lowrey, CH; Qian, L; Townsend, KJ; Yen, A; Zhou, P1
Barbour, SE; Carter, AD; Kapur, A; Rabah, D; Wong, C1
Conn, PM; Lin, X1
Flory, E; Grosse-Wilde, A; Hoffmeyer, A; Kunz, M; Ludwig, S; Neufeld, B; Rapp, UR1
Montessuit, C; Thorburn, A1
Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Tokuda, H; Uematsu, T1
Iguchi, A; Ikeda, S; Kanda, S; Koike, T; Kuzuya, M; Ramos, MA; Satake, S; Yoshino, K1
Kiley, SC; Parker, PJ; Whelan, RD1
Shibuya, M; Takahashi, T; Ueno, H1
Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G1
Gorospe, M; He, H; Holbrook, NJ; Trush, MA; Wang, X1
Harada, A; Kozawa, O; Tokuda, H; Uematsu, T1
Daaka, Y; McAllen, K; Shahabi, NA; Sharp, BM1
Chung, BS; Do, IR; Han, CS; Kang, CD; Kim, CM; Kim, KW; Kim, SH; Lee, EY1
Dickinson, CJ; Sawada, M; Stepan, VM; Todisco, A1
Johansen, B; Moens, U; Seternes, OM1
Chen, BC; Lin, LL; Lin, WW1
Martinez, JR; Sun, X; Zhang, GH1
Christensen, BN; Greeley, GH; Hellmich, MR; Ives, KL; Soloff, MS; Townsend, CM; Udupi, V1
Matthews, JS; O'Neill, LA1
Kozawa, O; Miwa, M; Tokuda, H; Uematsu, T1
Chan, JS; Chen, X; Filep, JG; Ingelfinger, JR; Tang, SS; Zhang, SL1
Kust, G; Leff, T; Oxender, D; Reddy, S; Shen, Xq; Taylor, DG; Yang, W1
Cohen, P; Shaw, M1
Moelling, K; Zimmermann, S1
Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U1
Boulougouris, G; Ellwood, CN; Hall, ND; McLeod, JD; Patel, YI; Sansom, DM; Walker, LS1
Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T1
Becker, M; Cato, AC; Klocker, H; Mink, S; Peterziel, H; Schonert, A1
Alessi, DR; Fahlman, R; Krook, A; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR1
Ishikawa, K; Okajima, F; Sato, K; Ui, M1
Bácsy, E; Bander, E; Buday, L; Faragó, A; Farkas, G; Sipeki, S; Ways, DK1
Côté, S; Gingras, S; Simard, J1
Ito, H; Ito, T; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Sakai, N; Tanabe, K; Uematsu, T1
Abe, K; Saito, H1
Aaronson, DS; Ajenjo, N; Ceballos, E; Crespo, P; León, J; Richard, C1
Hirasawa, N; Kobayashi, Y; Murakami, A; Ohuchi, K; Oikawa, S; Shiraishi, M1
Batty, IH; Herbert, TP; Kilhams, GR; Proud, CG1
Chen, X; Tang, S; Tashjian, AH1
Chen, Y; Deng, J; Wu, R1
Hayakawa, J; Hisamoto, K; Kanda, Y; Kimura, A; Kurachi, H; Murata, Y; Ohmichi, M; Tahara, M; Tasaka, K; Yokoi, T1
Agmon-Levin, N; Altevogt, P; Gutwein, P; Krauss, K; Mechtersheimer, S; Oleszewski, M1
Cochet, C; Fahmi, H; Hmama, Z; Joab, I; Opolon, P1
Foschi, M; Iozzo, RV; Kähäri, VM; Laine, P; Ravanti, L; Reunanen, N; Santra, M1
Creuzet, C; Dupouy-Camet, J; Robert-Gangneux, F; Roisin, MP1
Hatakeyama, D; Kawamura, H; Kozawa, O; Matsuno, H; Uematsu, T1
Baumgarten, CM; Dent, P; Fan, S; Gao, B; He, L; Kunos, G; Nguyen, VA; Sheng, X; Spector, M; Woodward, J1
Chandraratna, RA; Fleck, E; Goetze, S; Graf, K; Hsueh, WA; Kim, S; Kintscher, U; Law, RE; Nagpal, S; Wakino, S1
Bellingham, J; Clair, L; Rodriguez, JL; Wahlstrom, K; West, MA1
Kubo, Y; Miyashita, T1
Lee, C; Liu, X; Miura, K; Zweier, JL1
Davis, HW; Mak, AS; Osterhaus, SL; Packer, CS; Pelaez, NJ; Zhao, Y1
Holbrook, NJ; Martindale, JL; Wang, X1
Lin, WW; Wen, HC1
Hazzalin, CA; Mahadevan, LC; Rutault, K1
Azuma, N; Chen, EL; Gahtan, V; Ikeda, M; Kito, H; Nakajima, N; Sumpio, BE; Wang, X1
Andersson, K; Sundler, R1
Doggett, TA; Lemker, JL; Partridge, NC; Swarthout, JT1
Aguayo, C; Flores, C; Mann, GE; Montecinos, VP; Pearson, JD; Sobrevia, L; Wyatt, AW1
Brake, DK; Cengel, KA; Deszo, EL; Freund, GG; Kelley, KW1
Baldacci, G; Pizon, V1
Binder, BR; Clauss, M; Hofer, E; Lucerna, M; Mechtcheriakova, D; Schabbauer, G1
Chen, D; Davis, JS; Fong, HW1
Katsuyama, R; Kawasaki, T; Morioka, A; Oka, S1
Wenner, CE; Yan, S1
Kaneda, N; Murata, T; Niimi, Y1
Clipstone, NA; Riggins, PS1
Akimoto, K; Hattori, Y; Kakishita, H; Kasai, K; Matsumura, M1
Ding, B; Huang, SL; Li, YX; Zhang, SQ1
Grant, S; Vrana, JA1
Chung, BS; Kang, CD; Kang, HS; Kim, HD; Kim, KW; Kim, ND; Kim, SH; Lee, EY1
Nånberg, E; Olsson, AK1
Bauer, CK; Schledermann, W; Schwarz, JR; Wulfsen, I1
Chen, HC; Liang, CC1
Faubert Kaplan, BL; Herring, AC; Kaminski, NE1
Maher, P2
Hamada, H; Shimizu, T; Sugibayashi, R; Suzuki, T; Takeda, K; Yamamoto, N1
Kitahara, M; Naitoh, T; Tsuruzoe, N1
Clerk, A; Cole, SM; Pham, FH1
Azzi, A; Breyer, I1
Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV2
Thway, TM; Wolfe, MW1
Abe, K; Higashi, N; Hirai, M; Hirano, T; Miki, T; Mizuno, K; Nakajima, K; Sekimoto, T1
Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ1
Honma, M; Iizuka, H; Ishida-Yamamoto, A; Kiyama, H; Namikawa, K; Takahashi, H1
Huang, Q; Lau, SS; Monks, TJ; Weber, TJ1
Barthel, A; Grempler, R; Joost, HG; Schmoll, D; Walther, R1
Aggeli, IK; Beis, I; Gaitanaki, C; Lazou, A1
Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K1
Blumberg, JB; Clément, SA; Kitta, K; Remeika, J; Suzuki, YJ1
Castranova, V; Costa, M; Dong, Z; Huang, C; Ju, G; Li, J; Shi, X; Zhang, Q1
Chung, HT; Kim, NY; Kim, YM; Lee, HS; Oh, GS; Oh, H; Pae, HO; Shin, MK; Yun, YG1
Frey, BM; Frey, FJ; Heiniger, CD; Rochat, MK1
Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I1
Larsson, C; Svensson, K; Trollér, U; Zeidman, R1
Demirs, JT; Kochevar, IE; Zhuang, S1
Hoshi, S; Kuromitsu, J; Nagata, M; Nomoto, K; Tomari, S1
Bryson, JM; Coy, PE; Ma, J; Noboa, OA; Robey, RB; Santos, AV1
Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE1
Pérez-Tomás, R; Ramoneda, BM1
Cederberg, A; Enerbäck, S; Grønning, LM; Miura, N; Taskén, K1
Chan, JS; Chen, X; Filep, JG; Hohman, TC; Pang, L; To, C; Wang, TT; Wu, XH; Zhang, SL1
Aizawa, T; Hashizume, K; Iijima, S; Nakajima, K; Shigematsu, S; Yamauchi, K1
Gomez-Cambronero, J; Lehman, JA1
Kanayama, N; Kobayashi, H; Nishida, T; Suzuki, M; Takigawa, M; Terao, T1
Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH1
Andrew, SD; Capes-Davis, A; Delhanty, PJ; Marsh, DJ; Mulligan, LM; Robinson, BG1
Fleming, J; Höcker, M; Raychowdhury, R; Rosewicz, S; Schäfer, G; Wang, TC; Wiedenmann, B1
Hong, SI; Hong, YJ; Kuroki, T; Lee, HC; Lee, JY; Lee, SH; Lee, YS; Park, IC; Park, MJ; Rhee, CH; Shim, BS; Woo, SH1
Cho, YJ; Jeong, SW; Kim, JY; Kim, ON; Lee, SB1
Bock, BC; Gallo, KA; Hall, CS; Parameswaran, N; Sparks, HV; Spielman, WS1
Blomhoff, HK; Engedal, N1
Wen-Sheng, W1
Hughes, TR; Irvine, SA; Mead, JR; Ramji, DP; Singh, NN1
Braig, M; Dittmer, J; Hauser, CA; Lindemann, RK; Nordheim, A1
Coulonval, K; Dumont, JE; Lamy, F; Perpete, S; Vandeput, F1
Harada, A; Hirade, K; Ito, H; Kato, K; Kozawa, O; Matsuno, H; Oiso, Y; Tokuda, H1
Farnell, MB; He, H; Kogut, MH1
Aizu-Yokota, E; Funakoshi-Tago, M; Kasahara, T; Makuta, Y; Sonoda, Y; Takebe, Y; Yamamoto, D1
Bank, I; Chess, L; Goldstein, I; Koltakov, A; Li, J; Nir-Glickman, E; Roitelman, J1
Chain, BM; Cho, JY; Katz, DR1
Chang, YY; Sun, SH; Wang, CM1
Wang, Y; Yi, XJ; Yu, FS; Zhang, J1
Dinh, DH; Gujrati, M; Gumidyala, KV; Mohanam, S; Olivero, WC; Rao, JS; Waldron, KG; Yanamandra, N1
Lefèvre, F; Marcelo, P1
Evers, BM; Hu, W; Wang, Q; Wang, X1
Huang, SH; Shen, WJ; Wang, SM; Yeo, HL1
Chang, KC; Kang, YJ; Kim, HJ; Ko, YS; Lee, YS; Park, MK; Pyo, HS; Seo, HG; Yun-Choi, HS1
Bahramian, N; Bondjers, G; Olsson, U; Ostergren-Lundén, G1
Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M1
Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L1
Cohen, G; Hörl, WH1
Leithe, E; Rivedal, E1
Andrassy, M; Belov, D; Harja, E; Katus, HA; Leitges, M; Nawroth, PP; Schmidt, AM; Yan, SD; Yan, SF; Zou, YS1
Lefebvre, A; LeHoux, JG1
Cruciani, V; Flørenes, VA; Jørgensen, K; Mikalsen, SO; Skrede, M; Slipicevic, A1
Fenger, C; Holmskov, U; Kang, W; Leslie, G; Nielsen, O; Reid, KB1
Ahn, NS; Cho, SD; Hwang, JW; Jo, EH; Jung, JW; Jung, JY; Kang, KS; Kim, TY; Lee, BH; Lee, YS; Park, JS; Yang, SR; Yoon, BS1
Kuan, YH; Lin, CN; Lin, RH; Tsao, LT; Wang, JP1
Anderson, W; Asseffa, A; George, M; Spannhake, EW; Traore, K; Trush, MA1
Brinkmann, V; Churin, Y; Hekman, M; Rajalingam, K; Rapp, UR; Rudel, T; Sievers, C; Wunder, C1
Allagnat, F; Condorelli, DF; Haefliger, JA; Martin, D; Waeber, G1
Ila, R; Maniar, R; Pecherskaya, A; Solem, M1
Ilves, M; Kerkelä, R; Mäkinen, M; Orzechowski, HD; Paul, M; Pikkarainen, S; Ruskoaho, H; Tokola, H; Vuolteenaho, O1
Cao, X; Dawson, MI; Han, YH; Kolluri, SK; Lin, B; Lin, F; Reed, JC; Stebbins, J; Zhang, XK1
Blasi, F; Díaz, VM; Hurtado, M; Kort, EJ; Paciucci, R; Resnati, M; Thomson, T1
Fujii, T; Koike, K; Kuwano, M; Nakamura, AM; Shirouzu, K; Yamana, H; Yokoyama, G1
Bouillon, R; Mathieu, C; Overbergh, L; Stoffels, K; Verstuyf, A; Waer, M1
Adrian, TE; Bell, RH; Ding, XZ; Flesche, JB; Robin, TP; Salabat, MR; Talamonti, MS; Ujiki, MB1
Gao, Y; Li, AH; Pan, MX; Zhang, Y1
Burek, CL; Sharma, RB; Traore, K; Trush, MA1
Abe, K; Nishiura, T1
Back, SJ; Kim, CD; Kwon, YB; Lee, JH; Lee, YS; Park, JK; Piao, YJ; Seo, YJ; Sohn, KC; Suhr, KB1
Feng, JT; Hu, CP; Lin, MJ; Tang, YL; Yu, ME; Zhu, JQ1
Huang, H; Huang, WH; Liu, J; Luo, GX; Peng, DZ; Zheng, JS; Zhou, X1
Abel, J; Cline, JE; Fritsche, E; Moors, M1
Eggo, MC; Susarla, R; Watkinson, JC1
Capurro, E; Fortino, V; Maioli, E; Sacchi, G; Torricelli, C; Valacchi, G1
Davidson, B; Flørenes, VA; Jørgensen, K; Rosnes, AK; Skrede, M; Slipicevic, A; Trøen, G1
Adolfo García-Sáinz, J; Alcántara-Hernández, R1
Ballim, RD; Mowla, S; Prince, S; Teng, H1
Khattar, E; Kumar, V1
Benabbou, N; Faussat, AM; Hatmi, M; Karroum, A; Mirshahi, M; Mirshahi, P; Soria, J; Therwath, A1
Andreoli, V; Bocco, JL; De Paul, AL; Gutiérrez, S; Palmeri, CM; Petiti, JP; Sosa, Ldel V; Torres, AI1
Adachi, T; Hara, H; Kamiya, T; Makino, J1
Choi, YJ; Lee, SG; Yoon, JH1
Harada, T; Itamochi, H; Kawaguchi, W; Kigawa, J; Kudoh, A; Naniwa, J; Nonaka, M; Oishi, T; Sato, S; Shimada, M; Terakawa, N; Uegaki, K1
Chao, CY; Chen, HW; Li, CC; Lii, CK; Lin, LL; Liu, KL; Lu, CY1
Cheng, H; Dai, S; Deng, K; Fu, C; Li, Y; Meng, J; Meng, Y; Shen, A; Wang, G; Wang, H; Wei, D1
DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O1
Chen, Y; Huang, Z; Jin, Q; Li, W; Li, Y; Liang, Q; Liu, S; Lu, B; Sun, X; Zhou, Y1
Angel, J; Busca, A; Iqbal, S; Kumar, A; Saxena, M1
Varma, S; Voldman, J1
Cirone, M; D'Orazi, G; Faggioni, A; Garufi, A; Gilardini Montani, MS; Gonnella, R; Granato, M; Santarelli, R; Yadav, S1
Du, Y; Jiang, R; Shi, Y; Yu, W; Zeng, C; Zhang, A1
Chiou, HL; Hsieh, YH; Lin, CL; Lin, CY; Liu, CJ; Wu, MH; Yang, SF1
Hamilton, BJ; Stan, RV; Tse, D1

Other Studies

234 other study(ies) available for tetradecanoylphorbol acetate and pd 98059

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Stimulation of mitogen activated protein kinase by LDL and oxLDL in human U-937 macrophage-like cells.
    FEBS letters, 1996, May-06, Volume: 385, Issue:3

    Topics: Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chloroquine; Enzyme Inhibitors; Flavonoids; Humans; Lipoproteins, LDL; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Peptide Fragments; Pertussis Toxin; Phosphotransferases; Poly I; Polysaccharides; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1996
Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells.
    The Journal of biological chemistry, 1996, Jul-05, Volume: 271, Issue:27

    Topics: Amino Acid Sequence; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Fibroblast Growth Factor 2; Flavonoids; Growth Substances; Insulin; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Smooth, Vascular; Phosphorylation; Polyenes; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; Sirolimus; Substrate Specificity; Tetradecanoylphorbol Acetate; Thrombin

1996
Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival.
    The Journal of biological chemistry, 1996, Aug-23, Volume: 271, Issue:34

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Cyclic AMP; Enzyme Activation; Flavonoids; Ganglia, Sympathetic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Nerve Growth Factors; Neurons; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate

1996
Angiotensin II interferes with interleukin 6-induced Stat3 signaling by a pathway involving mitogen-activated protein kinase kinase 1.
    The Journal of biological chemistry, 1996, Sep-13, Volume: 271, Issue:37

    Topics: Angiotensin II; Animals; Basic-Leucine Zipper Transcription Factors; Cells, Cultured; Cricetinae; DNA-Binding Proteins; Drosophila Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flavonoids; Interleukin-6; Leucine Zippers; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors

1996
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
    Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295

    Topics: 3T3 Cells; Adipocytes; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Ligands; Mice; Mitogens; Mutation; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection

1996
Okadaic acid induces hyperphosphorylation of tau independently of mitogen-activated protein kinase activation.
    Journal of neurochemistry, 1997, Volume: 68, Issue:1

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Neuroglia; Neurons; Okadaic Acid; Phosphorylation; Rats; tau Proteins; Tetradecanoylphorbol Acetate

1997
Effect of growth factors on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Rat-1 fibroblasts.
    The Journal of biological chemistry, 1997, Jan-31, Volume: 272, Issue:5

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Culture Media, Serum-Free; Cyclic AMP; DNA; Endothelin-1; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Fructose-Bisphosphatase; Growth Substances; Lysophospholipids; Phosphofructokinase-1; Phosphofructokinase-2; Rats; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection

1997
Extracellular matrix is required for MAP kinase activation and proliferation of rat glomerular epithelial cells.
    Biochemical and biophysical research communications, 1997, Feb-03, Volume: 231, Issue:1

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Extracellular Matrix; Flavonoids; Kidney Glomerulus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Plastics; Rats; Tetradecanoylphorbol Acetate

1997
Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells.
    The American journal of physiology, 1997, Volume: 272, Issue:3 Pt 2

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Hypertonic Solutions; JNK Mitogen-Activated Protein Kinases; Kidney Medulla; Kidney Tubules, Collecting; Mannitol; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Saline Solution, Hypertonic; Substrate Specificity; Tetradecanoylphorbol Acetate

1997
Inhibition of ERK activation attenuates endothelin-stimulated airway smooth muscle cell proliferation.
    American journal of respiratory cell and molecular biology, 1997, Volume: 16, Issue:5

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Endothelins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogens; Muscle, Smooth; Myelin Basic Protein; Phosphorylation; Protein Kinase C; Rats; Recombinant Proteins; Respiratory System; Signal Transduction; Tetradecanoylphorbol Acetate

1997
Studies on the phosphorylation of eIF4E in Xenopus (XIK-2) kidney cells.
    Biochemical Society transactions, 1997, Volume: 25, Issue:2

    Topics: Animals; Cell Line; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Immunosuppressive Agents; Indoles; Kidney; Kinetics; Peptide Initiation Factors; Phosphorylation; Polyenes; Protein Kinase C; Sirolimus; Tetradecanoylphorbol Acetate; Xenopus

1997
Stimulation of osteopontin mRNA expression in HL-60 cells is independent of differentiation.
    Archives of biochemistry and biophysics, 1997, Jul-15, Volume: 343, Issue:2

    Topics: Alkaloids; Benzophenanthridines; Butyrates; Butyric Acid; Calcitriol; Cell Adhesion; Cell Adhesion Molecules; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Osteopontin; Phenanthridines; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tretinoin

1997
Roles for protein kinase C and mitogen-activated protein kinase in nicotine-induced secretion from bovine adrenal chromaffin cells.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Adrenal Medulla; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Flavonoids; Indoles; Kinetics; Maleimides; Nicotine; Norepinephrine; Potassium Chloride; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate

1997
Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells.
    The Journal of biological chemistry, 1997, Sep-12, Volume: 272, Issue:37

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned; Enzyme Activation; Enzyme Inhibitors; Flavonoids; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Megakaryocytes; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate

1997
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver.
    Gastroenterology, 1997, Volume: 113, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; Indoles; Isomerism; Isoproterenol; Kinetics; Liver; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Taurochenodeoxycholic Acid; Taurocholic Acid; Tetradecanoylphorbol Acetate

1997
Molecular mechanisms for the growth factor action of gastrin.
    The American journal of physiology, 1997, Volume: 273, Issue:4

    Topics: Animals; Benzodiazepinones; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Devazepide; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gastrins; Genes, fos; Hormone Antagonists; Humans; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinase 1; Pancreas; Pertussis Toxin; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Virulence Factors, Bordetella

1997
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.
    Journal of cellular physiology, 1997, Volume: 173, Issue:3

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate

1997
Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine.
    The Biochemical journal, 1997, Dec-01, Volume: 328 ( Pt 2)

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; DNA; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Ethanolamine; Flavonoids; Gene Expression Regulation, Enzymologic; Hydrolysis; Insulin; Lysophospholipids; Mice; Mitogens; Mitosis; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Sphingosine; Tetradecanoylphorbol Acetate

1997
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
    The Biochemical journal, 1997, Dec-01, Volume: 328 ( Pt 2)

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cytosol; Dinoprostone; Down-Regulation; Drug Interactions; Flavonoids; Guinea Pigs; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Trachea

1997
Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.
    The Journal of biological chemistry, 1997, Dec-05, Volume: 272, Issue:49

    Topics: Breast Neoplasms; Cell Division; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Replication; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1997
Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42/44 MAP kinase activation.
    Journal of lipid research, 1997, Volume: 38, Issue:11

    Topics: Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Flavonoids; Gene Expression Regulation; Humans; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Polymerase Chain Reaction; Protein Kinase C; Receptors, LDL; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1997
Ro31-8220 inhibits protein kinase C to block the phorbol ester-stimulated release of choline- and ethanolamine-metabolites from C6 glioma cells: p70 S6 kinase and MAPKAP kinase-1beta do not function downstream of PKC in activating PLD.
    FEBS letters, 1997, Nov-03, Volume: 417, Issue:1

    Topics: Androstadienes; Animals; Choline; Enzyme Inhibitors; Ethanolamine; Flavonoids; Glioma; Indoles; Phosphoinositide-3 Kinase Inhibitors; Phospholipase D; Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Sirolimus; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

1997
MAP and cdc2 kinase activities at germinal vesicle breakdown in Chaetopterus.
    Developmental biology, 1997, Nov-15, Volume: 191, Issue:2

    Topics: Animals; Blotting, Western; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Enzyme Activation; Enzyme Inhibitors; Fertilization; Flavonoids; Glycogen Synthase Kinase 3; Ionophores; Kinetin; MAP Kinase Kinase 1; Meiosis; Mitogen-Activated Protein Kinase Kinases; Oocytes; Phosphorylation; Phosphotyrosine; Polychaeta; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Purines; Tetradecanoylphorbol Acetate

1997
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
    Journal of neuroscience research, 1997, Dec-01, Volume: 50, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate

1997
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.
    Endocrinology, 1998, Volume: 139, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Flavonoids; Insulin; Male; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate

1998
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
    The Journal of biological chemistry, 1998, Jan-16, Volume: 273, Issue:3

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tetradecanoylphorbol Acetate; Threonine

1998
The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells.
    Oncogene, 1998, Jan-08, Volume: 16, Issue:1

    Topics: Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; G1 Phase; Genes, Reporter; Humans; Insulin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-jun; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1998
alpha-Thrombin inhibits signal transducers and activators of transcription 3 signaling by interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor in CCL39 cells.
    Archives of biochemistry and biophysics, 1998, Feb-15, Volume: 350, Issue:2

    Topics: Animals; Cell Line; Ciliary Neurotrophic Factor; Cricetinae; Cricetulus; Cytokines; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Gene Expression Regulation; Growth Inhibitors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Lymphokines; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Thrombin; Trans-Activators

1998
A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells.
    Experimental cell research, 1998, Feb-01, Volume: 238, Issue:2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Cycle; Cell Differentiation; Cytoskeletal Proteins; Enzyme Inhibitors; Fibronectins; Flavonoids; Humans; Leukemia, Erythroblastic, Acute; MAP Kinase Kinase Kinase 1; Megakaryocytes; Mitogen-Activated Protein Kinase 1; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1998
Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Mar-15, Volume: 160, Issue:6

    Topics: Calcineurin; CD28 Antigens; CD3 Complex; Cells, Cultured; Cytokines; Flavonoids; Humans; Lymphocyte Activation; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; RNA, Messenger; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate

1998
Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway.
    Journal of cell science, 1998, Volume: 111 ( Pt 8)

    Topics: Actins; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Adhesion; Cell Movement; Collagen; Desmosomes; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Hepatocyte Growth Factor; HT29 Cells; Humans; Laminin; Signal Transduction; Tetradecanoylphorbol Acetate

1998
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
    Cancer research, 1998, Mar-15, Volume: 58, Issue:6

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Head and Neck Neoplasms; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms.
    Biochimica et biophysica acta, 1998, Mar-06, Volume: 1391, Issue:1

    Topics: Amnion; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Humans; In Situ Hybridization; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate

1998
A novel interaction between inhibitory melatonin receptors and protein kinase C-dependent signal transduction in ovine pars tuberalis cells.
    Endocrinology, 1998, Volume: 139, Issue:4

    Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, fos; L Cells; Melatonin; Mice; Pituitary Gland; Protein Kinase C; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate

1998
Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.
    Biochemical and biophysical research communications, 1998, Apr-07, Volume: 245, Issue:1

    Topics: Anisomycin; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Protein Kinase C; Tetradecanoylphorbol Acetate

1998
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways.
    The Journal of biological chemistry, 1998, Apr-17, Volume: 273, Issue:16

    Topics: Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Humans; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Kidney; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Signal Transduction; Sorbitol; Stress, Physiological; Tetradecanoylphorbol Acetate; Transfection

1998
Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cell differentiation.
    The Journal of biological chemistry, 1998, Apr-17, Volume: 273, Issue:16

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Colforsin; Cyclic AMP; Enzyme Inhibitors; Flavonoids; Luciferases; Melanoma, Experimental; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monophenol Monooxygenase; Protein Kinase Inhibitors; Protein Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

1998
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
    The Biochemical journal, 1998, May-01, Volume: 331 ( Pt 3)

    Topics: ADP Ribose Transferases; Androstadienes; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Size; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Humans; Hypotonic Solutions; Indoles; Intestines; Iodine Radioisotopes; Maleimides; Osmotic Pressure; Phosphorylation; ras Proteins; Rubidium Radioisotopes; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin

1998
Activation of tissue-factor gene expression in breast carcinoma cells by stimulation of the RAF-ERK signaling pathway.
    Molecular carcinogenesis, 1998, Volume: 21, Issue:4

    Topics: Base Sequence; Benzoquinones; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Dactinomycin; DNA, Complementary; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Genistein; Humans; Hydroquinones; Lactams, Macrocyclic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Okadaic Acid; Phenols; Proto-Oncogene Proteins c-raf; Quinones; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factor AP-1; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured

1998
Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases.
    The Journal of biological chemistry, 1998, Jun-12, Volume: 273, Issue:24

    Topics: Actins; Atrial Natriuretic Factor; Calcium; Calmodulin; Cardiomegaly; Cell Division; Cells, Cultured; Flavonoids; Gene Expression Regulation; Genes, ras; Heart; Mitogen-Activated Protein Kinase 1; Ouabain; Protein Kinase C; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate

1998
Selective modulation of MAP kinase in embryonic palate cells.
    Journal of cellular physiology, 1998, Volume: 176, Issue:2

    Topics: Animals; Calcimycin; Carcinogens; Cells, Cultured; Cholera Toxin; Cyclic AMP; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Fetus; Flavonoids; Ionophores; Isoquinolines; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Palate; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta

1998
Identification of a novel inhibitor of mitogen-activated protein kinase kinase.
    The Journal of biological chemistry, 1998, Jul-17, Volume: 273, Issue:29

    Topics: Animals; Butadienes; COS Cells; DNA; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Kinetics; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-raf; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

1998
Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules.
    Oncogene, 1998, Jul-16, Volume: 17, Issue:2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flavonoids; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Up-Regulation

1998
Hsp27 phosphorylation is induced in alveolar macrophages exposed to CdO-coated silica particles.
    Biochemical and biophysical research communications, 1998, Jul-20, Volume: 248, Issue:2

    Topics: Animals; Cadmium Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Electrophoresis, Gel, Two-Dimensional; Flavonoids; Heat-Shock Proteins; Hydrogen Peroxide; Imidazoles; Macrophages, Alveolar; Oxides; Phosphoproteins; Phosphorylation; Pyridines; Quartz; Signal Transduction; Silicon Dioxide; Superoxides; Tetradecanoylphorbol Acetate

1998
Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization.
    Journal of leukocyte biology, 1998, Volume: 64, Issue:2

    Topics: Carcinogens; Enzyme Inhibitors; Flavonoids; Humans; Lipopolysaccharides; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Monocytes; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane B2; Tumor Cells, Cultured

1998
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Sep-15, Volume: 95, Issue:19

    Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-6; Ionomycin; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nitriles; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection

1998
Integrin ligation and PKC activation are required for migration of colon carcinoma cells.
    Journal of cell science, 1998, Volume: 111 ( Pt 20)

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Size; Chemotaxis; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Flow Cytometry; HT29 Cells; Humans; Insulin-Like Growth Factor I; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Tetradecanoylphorbol Acetate

1998
Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Cells, Cultured; Choline; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flavonoids; Isoenzymes; Kinetics; Male; Osmolar Concentration; Phosphatidylcholines; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Signal Transduction; Sorbitol; Tetradecanoylphorbol Acetate; Ultraviolet Rays

1998
Regulation of tyrosine hydroxylase gene expression during transdifferentiation of striatal neurons: changes in transcription factors binding the AP-1 site.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Oct-15, Volume: 18, Issue:20

    Topics: 1-Methyl-3-isobutylxanthine; Activating Transcription Factor 2; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Chamomile; Colforsin; Corpus Striatum; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dopamine; Enzyme Inhibitors; Female; Fibroblast Growth Factor 1; Flavonoids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; Neurons; Oils, Volatile; Phosphodiesterase Inhibitors; Plants, Medicinal; Pregnancy; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Repressor Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Tyrosine 3-Monooxygenase

1998
Activation of phospholipase A2 during differentiation of human haemopoietic progenitor cells.
    Biochemical Society transactions, 1998, Volume: 26, Issue:3

    Topics: Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cells, Cultured; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hematopoietic Stem Cells; Humans; Kinetics; Mitogen-Activated Protein Kinase 1; Organophosphonates; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Time Factors

1998
Role of p38 MAP kinase in myocardial stress.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:8

    Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Tetradecanoylphorbol Acetate

1998
Dependence of both spontaneous and antibody-dependent, granule exocytosis-mediated NK cell cytotoxicity on extracellular signal-regulated kinases.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Dec-15, Volume: 161, Issue:12

    Topics: Actins; Animals; Antibody-Dependent Cell Cytotoxicity; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cytoplasmic Granules; Cytoskeleton; Cytotoxicity, Immunologic; Dose-Response Relationship, Immunologic; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Extracellular Space; Flavonoids; Humans; Interferon-gamma; Jurkat Cells; Killer Cells, Natural; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptors, IgG; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured

1998
Isolation and characterization of a variant HL60 cell line defective in the activation of the NADPH oxidase by phorbol myristate acetate.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Dec-15, Volume: 161, Issue:12

    Topics: Androstadienes; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GTP-Binding Proteins; HL-60 Cells; Humans; Isoenzymes; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neoplasm Proteins; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella; Wortmannin

1998
Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation.
    The Journal of biological chemistry, 1999, Jan-15, Volume: 274, Issue:3

    Topics: Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Molecular Sequence Data; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Serum Response Factor; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation

1999
Mature macrophage cell lines exhibit variable responses to LPS.
    Molecular immunology, 1998, Volume: 35, Issue:14-15

    Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage Activation; Macrophage-1 Antigen; Macrophages; Mice; Phospholipases A; Phospholipases A2; Phospholipids; Signal Transduction; Tetradecanoylphorbol Acetate; Tritium

1998
Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways.
    Endocrinology, 1999, Volume: 140, Issue:1

    Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, Reporter; Gonadotropin-Releasing Hormone; Indoles; Maleimides; Mice; Pituitary Gland; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-raf; Rats; Receptors, LHRH; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection

1999
Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes.
    The Journal of biological chemistry, 1999, Feb-12, Volume: 274, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Imidazoles; Ionomycin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1999
Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists.
    The Journal of biological chemistry, 1999, Mar-26, Volume: 274, Issue:13

    Topics: Animals; Cardiomegaly; Cell Cycle Proteins; Cells, Cultured; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Flavonoids; Gene Expression Regulation; Genes, ras; Genes, Reporter; Glucose Transporter Type 1; Glucose Transporter Type 4; Heart Ventricles; Immediate-Early Proteins; Microscopy, Fluorescence; Monosaccharide Transport Proteins; Muscle Proteins; Phenylephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection

1999
Involvement of p42/p44 MAP kinase in endothelin-1-induced interleukin-6 synthesis in osteoblast-like cells.
    Bone, 1999, Volume: 24, Issue:4

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; Tetradecanoylphorbol Acetate

1999
Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice.
    Experimental cell research, 1999, May-01, Volume: 248, Issue:2

    Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Cattle; Cell Adhesion; Cell Survival; Cells, Cultured; Collagen; Endothelium, Vascular; Fibroblast Growth Factor 2; Flavonoids; Hydroxamic Acids; Integrins; Metalloendopeptidases; Neovascularization, Physiologic; Protein Kinase Inhibitors; Protein Kinases; Receptors, Vitronectin; Tetradecanoylphorbol Acetate

1999
Tetradecanoyl phorbol acetate-induced microtubule reorganization is required for sustained mitogen-activated protein kinase activation and morphological differentiation of U937 cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1999, Volume: 10, Issue:4

    Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cloning, Molecular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Microtubules; Mitogen-Activated Protein Kinase 1; Nocodazole; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Time Factors; U937 Cells

1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
    Oncogene, 1999, Apr-01, Volume: 18, Issue:13

    Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

1999
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin

1999
Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1999, Volume: 10, Issue:5

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; JNK Mitogen-Activated Protein Kinases; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mitogens; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts.
    Cellular signalling, 1999, Volume: 11, Issue:5

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dinoprost; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Osteoblasts; Sodium Fluoride; Tetradecanoylphorbol Acetate

1999
Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner.
    Journal of neuroimmunology, 1999, Feb-01, Volume: 94, Issue:1-2

    Topics: Adjuvants, Immunologic; Animals; Benzoquinones; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; GTPase-Activating Proteins; Humans; Jurkat Cells; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; Pertussis Toxin; Phosphorylation; Proteins; Proto-Oncogene Proteins c-fos; Quinones; ras GTPase-Activating Proteins; ras Proteins; Receptors, Opioid, delta; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1999
Activation of NF-kappaB mediates the PMA-induced differentiation of K562 cells.
    Cancer letters, 1998, Oct-23, Volume: 132, Issue:1-2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; K562 Cells; NF-kappa B; Oligonucleotides, Antisense; Tetradecanoylphorbol Acetate

1998
Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
    Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Agents; Binding Sites; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Colonic Neoplasms; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gastrins; Gene Expression Regulation; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Meglumine; Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Rats; Receptors, Cholecystokinin; Recombinant Proteins; Response Elements; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured

1999
A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:7

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Immediate-Early Proteins; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphoprotein Phosphatases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation

1999
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
    European journal of pharmacology, 1999, May-28, Volume: 373, Issue:1

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate

1999
Inhibition of Ca2+ influx by pentoxifylline in NR8383 alveolar macrophages.
    Immunopharmacology, 1999, Volume: 43, Issue:1

    Topics: Animals; Calcium Channels; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Diglycerides; Enzyme Activation; Flavonoids; Humans; Macrophages, Alveolar; Pentoxifylline; Phosphodiesterase Inhibitors; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Zymosan

1999
Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion.
    The Journal of biological chemistry, 1999, Aug-20, Volume: 274, Issue:34

    Topics: Bombesin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Flavonoids; Humans; MAP Kinase Kinase Kinase 1; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Bombesin; Tetradecanoylphorbol Acetate

1999
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.
    Cytokine, 1999, Volume: 11, Issue:9

    Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Interleukin-1; Interleukin-2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured

1999
Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C.
    Endocrinology, 1999, Volume: 140, Issue:11

    Topics: Animals; Animals, Newborn; Bridged-Ring Compounds; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Norbornanes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones

1999
Insulin inhibits angiotensinogen gene expression via the mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
    Endocrinology, 1999, Volume: 140, Issue:11

    Topics: Androstadienes; Angiotensinogen; Animals; Cell Line, Transformed; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Insulin; Kidney Tubules, Proximal; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Wortmannin

1999
Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4.
    The Journal of biological chemistry, 1999, Nov-12, Volume: 274, Issue:46

    Topics: Apolipoprotein C-III; Apolipoproteins C; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Hepatocyte Nuclear Factor 4; Humans; Mitogen-Activated Protein Kinases; Phosphoproteins; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection

1999
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
    FEBS letters, 1999, Nov-12, Volume: 461, Issue:1-2

    Topics: 3T3 Cells; Androstadienes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin

1999
Phosphorylation and regulation of Raf by Akt (protein kinase B).
    Science (New York, N.Y.), 1999, Nov-26, Volume: 286, Issue:5445

    Topics: Cell Division; Cell Line; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Fusion Proteins; Signal Transduction; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
    Neuroscience, 1999, Volume: 94, Issue:3

    Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate

1999
Lack of activation induced cell death in human T blasts despite CD95L up-regulation: protection from apoptosis by MEK signalling.
    Immunology, 1999, Volume: 98, Issue:4

    Topics: Antibodies, Monoclonal; Apoptosis; Biological Assay; Calcium; CD3 Complex; Cells, Cultured; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Flavonoids; Flow Cytometry; Humans; In Situ Nick-End Labeling; Lymphocyte Activation; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate

1999
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells.
    Thrombosis and haemostasis, 1999, Volume: 82, Issue:5

    Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates

1999
Rapid signalling by androgen receptor in prostate cancer cells.
    Oncogene, 1999, Nov-04, Volume: 18, Issue:46

    Topics: Adenocarcinoma; Androgen Antagonists; Cell Nucleus; Cytoplasm; Dihydrotestosterone; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Indoles; Ligands; Male; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Receptors, Androgen; Recombinant Fusion Proteins; Testosterone; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured

1999
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
    The Journal of biological chemistry, 2000, Jan-14, Volume: 275, Issue:2

    Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Glycogen; Imidazoles; In Vitro Techniques; Indoles; Insulin; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate

2000
Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells.
    Brain research. Molecular brain research, 1999, Dec-10, Volume: 74, Issue:1-2

    Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelins; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Glioma; GTP-Binding Proteins; Immediate-Early Proteins; Lysophospholipids; Mitogen-Activated Protein Kinases; Naphthalenes; Pertussis Toxin; Platelet-Derived Growth Factor; Protein Kinase C; Rats; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella

1999
Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering.
    Cellular signalling, 1999, Volume: 11, Issue:12

    Topics: Carcinoma, Hepatocellular; Cell Movement; Chromones; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitin-Protein Ligases

1999
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:2

    Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin

2000
p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:2

    Topics: Animals; Aorta; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Immunoassay; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylation; Protein Kinase C; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Vasopressins

2000
The p44/42 mitogen-activated protein kinase cascade is involved in the induction and maintenance of astrocyte stellation mediated by protein kinase C.
    Neuroscience research, 2000, Volume: 36, Issue:3

    Topics: Animals; Astrocytes; Bucladesine; Butadienes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate

2000
Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation.
    The Journal of biological chemistry, 2000, Mar-10, Volume: 275, Issue:10

    Topics: Cell Differentiation; Cell Division; Enzyme Activation; Flavonoids; Humans; Leukemia, Myeloid; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2000
Participation of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production in murine macrophage RAW 264.7 cells.
    British journal of pharmacology, 2000, Volume: 129, Issue:3

    Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Histamine Release; Imidazoles; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thapsigargin

2000
Distinct signalling pathways mediate insulin and phorbol ester-stimulated eukaryotic initiation factor 4F assembly and protein synthesis in HEK 293 cells.
    The Journal of biological chemistry, 2000, Apr-14, Volume: 275, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Cycle Proteins; Cell Line; Eukaryotic Initiation Factor-4F; Flavonoids; Humans; Insulin; Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate

2000
Novel action of pituitary adenylate cyclase-activating polypeptide. Stimulation of extracellular acidification in rat pituitary GH4C1 cells.
    Cellular signalling, 2000, Volume: 12, Issue:4

    Topics: Animals; Calcium; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Hydrogen-Ion Concentration; Kinetics; Mitogen-Activated Protein Kinases; Naphthalenes; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone

2000
Induction of cell cornification and enhanced squamous-cell marker SPRR1 gene expression by phorbol ester are regulated by different signaling pathways in human conducting airway epithelial cells.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:5

    Topics: Biomarkers; Cell Size; Cornified Envelope Proline-Rich Proteins; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gene Expression Regulation; Humans; Indoles; Lactams; Maleimides; Membrane Proteins; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Protein Kinase C; Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Trachea; Transcriptional Activation

2000
Activation of the luteinizing hormone beta promoter by gonadotropin-releasing hormone requires c-Jun NH2-terminal protein kinase.
    The Journal of biological chemistry, 2000, Jul-14, Volume: 275, Issue:28

    Topics: Animals; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, jun; Gonadotropin-Releasing Hormone; JNK Mitogen-Activated Protein Kinases; Kinetics; Luciferases; Luteinizing Hormone; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Virulence Factors, Bordetella

2000
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.
    The Journal of biological chemistry, 2000, May-19, Volume: 275, Issue:20

    Topics: Animals; Antigens, Surface; Breast Neoplasms; Cell Size; CHO Cells; Cricetinae; Disintegrins; Enzyme Inhibitors; Female; Flavonoids; Humans; Leukocyte L1 Antigen Complex; Membrane Glycoproteins; Metalloendopeptidases; Mice; Neural Cell Adhesion Molecules; Neuroblastoma; Phosphorylation; Protease Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Vanadates

2000
Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway.
    Journal of virology, 2000, Volume: 74, Issue:13

    Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins

2000
Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts.
    The Biochemical journal, 2000, Jul-01, Volume: 349, Issue:Pt 1

    Topics: 3T3 Cells; Adenoviridae; Adult; Animals; Cell Division; Cell Movement; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Decorin; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Matrix Proteins; Female; Fibroblasts; Flavonoids; Genetic Vectors; Humans; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection

2000
Involvement of the mitogen-activated protein (MAP) kinase signalling pathway in host cell invasion by Toxoplasma gondii.
    Parasite (Paris, France), 2000, Volume: 7, Issue:2

    Topics: Animals; Bombesin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Indoles; Mitogen-Activated Protein Kinases; Models, Biological; Signal Transduction; Tetradecanoylphorbol Acetate; Toxoplasma

2000
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
    Cellular signalling, 2000, Volume: 12, Issue:6

    Topics: Animals; Endothelial Growth Factors; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Imidazoles; Lymphokines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Protein Kinase C; Pyridines; Pyrrolidinones; Receptor, Endothelin A; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
    Experimental cell research, 2000, Jul-10, Volume: 258, Issue:1

    Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin

2000
Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.
    European journal of pharmacology, 2000, Aug-11, Volume: 401, Issue:3

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Cell Movement; Chemokine CCL2; Chemotaxis; Chromans; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Monocytes; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Rosiglitazone; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Tissue Inhibitor of Metalloproteinase-1; Transcription Factors; Troglitazone; Tumor Cells, Cultured

2000
Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Indoles; Lactams; Lipopolysaccharides; Macrophages, Peritoneal; Male; Maleimides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2000
Extracellular Ca2+ sensitivity of mGluR1alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
    Receptors & channels, 2000, Volume: 7, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Cell Size; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Dyes; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Isoquinolines; MAP Kinase Signaling System; Protein Kinase C; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases

2000
Biphasic regulation of leukocyte superoxide generation by nitric oxide and peroxynitrite.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Blotting, Western; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Flavonoids; Humans; Inflammation; Metalloporphyrins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NADPH Oxidases; Nerve Tissue Proteins; Neutrophils; Nitrates; Nitric Oxide; Oxygen; Phosphorylation; Receptors, Steroid; Receptors, Thyroid Hormone; Spin Trapping; Superoxides; Tetradecanoylphorbol Acetate; Time Factors

2000
MAPK and PKC activity are not required for H(2)O(2)-induced arterial muscle contraction.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:3

    Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flavonoids; Hydrogen Peroxide; In Vitro Techniques; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Potassium Chloride; Protein Kinase C; Protein Serine-Threonine Kinases; Pulmonary Artery; Swine; Tetradecanoylphorbol Acetate; Vasoconstriction

2000
Requirement for ERK activation in cisplatin-induced apoptosis.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Caspases; Cell Line; Cell Survival; Cisplatin; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HeLa Cells; Humans; Indoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Time Factors

2000
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
    Journal of cellular biochemistry, 2000, Sep-14, Volume: 79, Issue:4

    Topics: Acetophenones; Arachidonic Acid; Benzopyrans; Calcium; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin

2000
Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts.
    The Journal of biological chemistry, 2001, Mar-02, Volume: 276, Issue:9

    Topics: Cell Differentiation; Cells, Cultured; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Lipopolysaccharide Receptors; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2001
Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:6

    Topics: Animals; Cattle; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pulmonary Artery; Pyridines; Response Elements; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2000
Signalling to translational activation of tumour necrosis factor-alpha expression in human THP-1 cells.
    Cytokine, 2000, Volume: 12, Issue:12

    Topics: Anisomycin; Blotting, Northern; Blotting, Western; Butadienes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Ionophores; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha

2000
Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.
    The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Blotting, Western; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Peptides; Phosphorylation; Plasmids; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection

2001
Regulation of adenosine transport by D-glucose in human fetal endothelial cells: involvement of nitric oxide, protein kinase C and mitogen-activated protein kinase.
    The Journal of physiology, 2000, Dec-15, Volume: 529 Pt 3

    Topics: Adenosine; Biological Transport; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Fetus; Flavonoids; Glucose; Humans; Mitogen-Activated Protein Kinases; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Penicillamine; Protein Kinase C; S-Nitroso-N-Acetylpenicillamine; Tetradecanoylphorbol Acetate; Thioinosine

2000
CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Blotting, Western; Cell Differentiation; Cell Line; Cytoplasm; Enzyme Activation; Flavonoids; Flow Cytometry; Genetic Vectors; Humans; Isoenzymes; Leukocyte Common Antigens; Macrophage-1 Antigen; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; U937 Cells

2001
Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.
    Oncogene, 2000, Dec-07, Volume: 19, Issue:52

    Topics: Androstadienes; Blood Proteins; Blotting, Western; Cell Division; Cell Line; Cyclic AMP; Down-Regulation; Enzyme Activation; Flavonoids; Guanosine Diphosphate; Guanosine Triphosphate; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; rap1 GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Wortmannin

2000
Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:1

    Topics: Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Genes, Dominant; Humans; I-kappa B Kinase; Immediate-Early Proteins; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protein Kinase C; Protein Serine-Threonine Kinases; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Substrate Specificity; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factors; Tumor Necrosis Factor-alpha; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
Induction of c-fos and c-jun messenger ribonucleic acid expression by prostaglandin F2alpha is mediated by a protein kinase C-dependent extracellular signal-regulated kinase mitogen-activated protein kinase pathway in bovine luteal cells.
    Endocrinology, 2001, Volume: 142, Issue:2

    Topics: Animals; Cattle; Cell Nucleus; Cells, Cultured; Corpus Luteum; Dinoprost; Enzyme Inhibitors; Female; Flavonoids; Immunoblotting; Mitogen-Activated Protein Kinases; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tetradecanoylphorbol Acetate

2001
Expression of macrophage asialoglycoprotein-binding protein is induced through MAPK classical pathway.
    Biochemical and biophysical research communications, 2001, Feb-09, Volume: 280, Issue:5

    Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Lectins; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Receptors, Cell Surface; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; U937 Cells

2001
Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.
    Journal of cellular physiology, 2001, Volume: 186, Issue:3

    Topics: Animals; Cell Division; Cell Line; Cell Membrane; Cyclin D1; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Flavonoids; Indoles; Isoenzymes; Kinetics; Maleimides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates

2001
Characterization of the 5'-flanking region of the rat TIS11 gene.
    Molecular and cellular biochemistry, 2000, Volume: 214, Issue:1-2

    Topics: Animals; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Immediate-Early; Genes, Reporter; Immediate-Early Proteins; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinase Kinases; PC12 Cells; Promoter Regions, Genetic; Protein Kinase C; Rats; Sequence Deletion; Tetradecanoylphorbol Acetate; Tristetraprolin

2000
T cell activation signals upregulate CBP-dependent transcriptional activity.
    Biochemical and biophysical research communications, 2001, Mar-09, Volume: 281, Issue:4

    Topics: Antibodies, Monoclonal; Calcineurin; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinases; CD3 Complex; CREB-Binding Protein; DNA, Recombinant; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Ionomycin; Ionophores; Jurkat Cells; Luciferases; Nuclear Proteins; Plasmids; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transfection; Up-Regulation

2001
Glycated serum albumin-induced vascular smooth muscle cell proliferation through activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by protein kinase C.
    Biochemical and biophysical research communications, 2001, Mar-09, Volume: 281, Issue:4

    Topics: Animals; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Indoles; Isoenzymes; Luciferases; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Recombinant Fusion Proteins; Serum Albumin; Tetradecanoylphorbol Acetate; Transcriptional Activation

2001
Effect of PKC-zeta mediating Ang II-stimulated activation of CCDPK on rat cardiac fibroblast proliferation.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:2

    Topics: Angiotensin II; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Flavonoids; Isoenzymes; Mitogen-Activated Protein Kinase Kinases; Myocardium; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate

2000
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
    Blood, 2001, Apr-01, Volume: 97, Issue:7

    Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins

2001
Extracellular signal-regulated kinase/90-KDA ribosomal S6 kinase/nuclear factor-kappa B pathway mediates phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells.
    The Journal of biological chemistry, 2001, Apr-20, Volume: 276, Issue:16

    Topics: Amino Acid Substitution; Antigens, CD; Cell Differentiation; Enzyme Inhibitors; Flavonoids; Humans; Integrin beta3; K562 Cells; MAP Kinase Signaling System; Megakaryocytes; Mitogen-Activated Protein Kinases; Molecular Weight; Mutagenesis, Site-Directed; NF-kappa B; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Tetradecanoylphorbol Acetate; Transfection

2001
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells.
    Experimental cell research, 2001, Apr-15, Volume: 265, Issue:1

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GAP-43 Protein; Gene Expression; Humans; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Mitogens; Neurites; Neuroblastoma; Neuropeptide Y; Nuclear Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; ras Proteins; Receptor, trkA; Serum Response Factor; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2001
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.
    The Journal of physiology, 2001, Apr-01, Volume: 532, Issue:Pt 1

    Topics: Animals; Arachidonic Acid; Cation Transport Proteins; Cells, Cultured; Cholecystokinin; Colforsin; DNA-Binding Proteins; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flavonoids; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Membrane Potentials; Membrane Transport Proteins; Patch-Clamp Techniques; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Trans-Activators; Transcriptional Regulator ERG; Tyrphostins; Vasoactive Intestinal Peptide

2001
Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering.
    The Journal of biological chemistry, 2001, Jun-15, Volume: 276, Issue:24

    Topics: Animals; Antigens, CD; Cell Adhesion; Cell Line; Cell Movement; Chromones; Cycloheximide; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Integrin alpha2; Integrins; Kidney; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Receptors, Collagen; Recombinant Proteins; Tetradecanoylphorbol Acetate

2001
Modulation of CREB and NF-kappaB signal transduction by cannabinol in activated thymocytes.
    Cellular signalling, 2001, Volume: 13, Issue:4

    Topics: Animals; Blotting, Western; Cannabinol; Carcinogens; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Interleukin-2; Ionomycin; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors

2001
How protein kinase C activation protects nerve cells from oxidative stress-induced cell death.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, May-01, Volume: 21, Issue:9

    Topics: Animals; Buthionine Sulfoximine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Death; Cell Survival; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Homocysteine; Isoenzymes; Mice; Mitogen-Activated Protein Kinases; Neurons; Oxidative Stress; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Rats; Reactive Oxygen Species; Tetradecanoylphorbol Acetate

2001
Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1.
    Oncogene, 2001, Mar-08, Volume: 20, Issue:10

    Topics: Adenoviridae; Blotting, Northern; Blotting, Western; Carcinogens; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Primers; Enzyme Inhibitors; Flavonoids; Humans; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Naphthol AS D Esterase; Prostatic Neoplasms; Protein Kinase C; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation

2001
Tumor necrosis factor-alpha is induced through phorbol ester--and glycated human albumin-dependent pathway in THP-1 cells.
    Cellular signalling, 2001, Volume: 13, Issue:5

    Topics: Carcinogens; Catalase; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Insulin Resistance; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase C; Serum Albumin; Signal Transduction; Staurosporine; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2001
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
    Advances in enzyme regulation, 2001, Volume: 41

    Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Chromones; Electrophoresis, Gel, Two-Dimensional; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hypertrophy; Insulin; Intracellular Signaling Peptides and Proteins; Morpholines; Myocardium; Oxidative Stress; Peptide Initiation Factors; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors

2001
Differential inhibition by alpha- and beta-tocopherol of human erythroleukemia cell adhesion: role of integrins.
    Free radical biology & medicine, 2001, Jun-15, Volume: 30, Issue:12

    Topics: Antibodies, Monoclonal; Cell Adhesion; Down-Regulation; Flavonoids; Flow Cytometry; Humans; Integrins; Isoenzymes; K562 Cells; Leukemia, Erythroblastic, Acute; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; U937 Cells; Vitamin E

2001
Persistent versus transient map kinase (ERK) activation in the proliferation of lung epithelial type 2 cells.
    Experimental lung research, 2001, Volume: 27, Issue:4

    Topics: Animals; Cattle; Cell Division; Cells, Cultured; Culture Media; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pulmonary Alveoli; Rats; Tetradecanoylphorbol Acetate

2001
Epidermal growth factor regulation of equine glycoprotein hormone alpha subunit expression in trophoblast cells.
    Biology of reproduction, 2001, Volume: 65, Issue:1

    Topics: Animals; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Epidermal Growth Factor; Female; Flavonoids; Glycoprotein Hormones, alpha Subunit; Horses; Mitogen-Activated Protein Kinase Kinases; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Trophoblasts

2001
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
    Oncogene, 2001, Jun-14, Volume: 20, Issue:27

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cytokine Receptor gp130; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-6; Liver Neoplasms; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2001
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
    Biochemical and biophysical research communications, 2001, Jul-13, Volume: 285, Issue:2

    Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins

2001
Expression of human cystatin A by keratinocytes is positively regulated via the Ras/MEKK1/MKK7/JNK signal transduction pathway but negatively regulated via the Ras/Raf-1/MEK1/ERK pathway.
    The Journal of biological chemistry, 2001, Sep-28, Volume: 276, Issue:39

    Topics: Adenoviridae; Blotting, Northern; Blotting, Western; Carcinogens; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Cystatins; DNA, Complementary; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Dominant; Humans; Immunohistochemistry; Keratinocytes; MAP Kinase Kinase 1; MAP Kinase Kinase 7; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection

2001
Differential regulation of redox responsive transcription factors by the nephrocarcinogen 2,3,5-Tris(glutathion-S-yl)hydroquinone.
    Chemical research in toxicology, 2001, Volume: 14, Issue:7

    Topics: Carcinogens; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Glutathione; Humans; Hydrogen Peroxide; Hydroquinones; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; MAP Kinase Kinase Kinase 1; NF-kappa B; Nuclear Proteins; Oxidative Stress; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Regulatory Factor X Transcription Factors; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors

2001
Phorbol ester-induced activation of mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase and extracellular-signal-regulated protein kinase decreases glucose-6-phosphatase gene expression.
    The Biochemical journal, 2001, Aug-01, Volume: 357, Issue:Pt 3

    Topics: Animals; Cell Cycle Proteins; Dual Specificity Phosphatase 1; Enzyme Activation; Flavonoids; Gene Expression; Glucose-6-Phosphatase; Immediate-Early Proteins; Insulin; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2001
Activation of multiple MAPK pathways (ERKs, JNKs, p38-MAPK) by diverse stimuli in the amphibian heart.
    Molecular and cellular biochemistry, 2001, Volume: 221, Issue:1-2

    Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heart; JNK Mitogen-Activated Protein Kinases; Kinetics; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Perfusion; Phosphorylation; Ranidae; Rats; Rats, Wistar; Sorbitol; Tetradecanoylphorbol Acetate

2001
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
    Cell stress & chaperones, 2001, Volume: 6, Issue:1

    Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2001
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
    Toxicology, 2001, Oct-15, Volume: 167, Issue:2

    Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin

2001
Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line.
    The Biochemical journal, 2001, Oct-15, Volume: 359, Issue:Pt 2

    Topics: Animals; Cell Line; DNA-Binding Proteins; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; GATA4 Transcription Factor; Hydrogen Peroxide; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Tetradecanoylphorbol Acetate; Transcription Factors

2001
Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo.
    Molecular and cellular biochemistry, 2001, Volume: 222, Issue:1-2

    Topics: Animals; Cadmium; Carcinogens; Cell Line; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; Flavonoids; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Ultraviolet Rays

2001
Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe.
    In vitro & molecular toxicology, 2001,Summer, Volume: 14, Issue:2

    Topics: Apoptosis; DNA Fragmentation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Monocytic, Acute; Mistletoe; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Plant Preparations; Plant Proteins; Pyridines; Ribosome Inactivating Proteins, Type 2; Signal Transduction; Tetradecanoylphorbol Acetate; Toxins, Biological; U937 Cells

2001
TNF-alpha enhances intracellular glucocorticoid availability.
    FEBS letters, 2001, Nov-02, Volume: 507, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Cells, Cultured; Colforsin; Corticosterone; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Glucose; Hydroxysteroid Dehydrogenases; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2001
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
    British journal of pharmacology, 2001, Volume: 134, Issue:6

    Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

2001
A PKCbeta isoform mediates phorbol ester-induced activation of Erk1/2 and expression of neuronal differentiation genes in neuroblastoma cells.
    FEBS letters, 2001, Nov-09, Volume: 508, Issue:1

    Topics: Cell Differentiation; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; GAP-43 Protein; Gene Expression Regulation; Genes, Reporter; Isoenzymes; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurites; Neuroblastoma; Neurons; Neuropeptide Y; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Pyrroles; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2001
Protein kinase C inhibits singlet oxygen-induced apoptosis by decreasing caspase-8 activation.
    Oncogene, 2001, Oct-11, Volume: 20, Issue:46

    Topics: Apoptosis; Arabidopsis Proteins; Blotting, Western; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cells, Cultured; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Fatty Acid Desaturases; Flavonoids; HL-60 Cells; Humans; Ligands; MAP Kinase Signaling System; Membrane Potentials; Microscopy, Confocal; Mitochondria; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ultraviolet Rays

2001
High glucose induced VEGF expression via PKC and ERK in glomerular podocytes.
    Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1

    Topics: Animals; Cell Differentiation; Cell Line; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endothelial Growth Factors; Enzyme Inhibitors; Flavonoids; Glucose; Kidney; Leucine; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
    The Journal of biological chemistry, 2002, Apr-26, Volume: 277, Issue:17

    Topics: Animals; Cell Line; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glomerular Mesangium; Glucose; Heparin-binding EGF-like Growth Factor; Hexokinase; Immunohistochemistry; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine

2002
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
    Journal of neuro-oncology, 2001, Volume: 55, Issue:2

    Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine; Histamine H1 Antagonists; Humans; Inositol Phosphates; Protein Kinase C; Pyrilamine; Receptors, Histamine H1; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Type C Phospholipases

2001
Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin.
    Biochemical pharmacology, 2002, Feb-01, Volume: 63, Issue:3

    Topics: Anti-Bacterial Agents; Apoptosis; Carcinogens; Drug Interactions; Enzyme Activation; Flavonoids; Humans; Immunosuppressive Agents; Mitogen-Activated Protein Kinases; Prodigiosin; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2002
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:4

    Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; DNA-Binding Proteins; Down-Regulation; Enzyme Inhibitors; Flavonoids; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Insulin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha; Wortmannin

2002
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
    Oncogene, 2002, Mar-27, Volume: 21, Issue:13

    Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors

2002
Molecular mechanism(s) of insulin action on the expression of the angiotensinogen gene in kidney proximal tubular cells.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2000, Volume: 1, Issue:2

    Topics: Androstadienes; Angiotensinogen; Animals; Artificial Gene Fusion; Cell Line; Diglycerides; Enzyme Inhibitors; Flavonoids; Gene Expression; Glucose; Human Growth Hormone; Humans; Insulin; Kidney Tubules, Proximal; Naphthalenes; Opossums; Peptide Fragments; Promoter Regions, Genetic; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin

2000
IGF-1 regulates migration and angiogenesis of human endothelial cells.
    Endocrine journal, 1999, Volume: 46 Suppl

    Topics: Androstadienes; Cell Movement; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Insulin-Like Growth Factor I; Morpholines; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Wortmannin

1999
Molecular crosstalk between p70S6k and MAPK cell signaling pathways.
    Biochemical and biophysical research communications, 2002, Apr-26, Volume: 293, Issue:1

    Topics: Amino Acid Sequence; Cell Division; Chemotaxis, Leukocyte; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; MAP Kinase Signaling System; Neutrophils; Phosphorylation; Receptor Cross-Talk; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomes; Substrate Specificity; Tetradecanoylphorbol Acetate

2002
Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.
    European journal of biochemistry, 2002, Volume: 269, Issue:16

    Topics: Bone Neoplasms; Butadienes; Carcinoma; Chondrosarcoma; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Ovarian Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Trypsin Inhibitor, Kunitz Soybean; Tumor Cells, Cultured

2002
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
    Molecular carcinogenesis, 2002, Volume: 35, Issue:1

    Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation

2002
Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway.
    Gene, 2002, Sep-18, Volume: 298, Issue:1

    Topics: Cell Size; DNA-Binding Proteins; Down-Regulation; Drosophila Proteins; Early Growth Response Protein 1; Electrophoretic Mobility Shift Assay; Flavonoids; Gene Expression Regulation; Humans; Immediate-Early Proteins; Luciferases; MAP Kinase Signaling System; Nuclear Proteins; Oligonucleotides; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Response Elements; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured

2002
Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromog
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:12

    Topics: Binding Sites; Cell Nucleus; Chromogranin A; Chromogranins; Cyclic AMP Response Element-Binding Protein; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Gastrins; Humans; Immediate-Early Proteins; Immunoblotting; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Response Elements; Signal Transduction; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2002
Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in capillary endothelial cells.
    International journal of oncology, 2003, Volume: 22, Issue:1

    Topics: Animals; Capillaries; Cattle; Endothelium, Vascular; Enzyme Activation; Flavonoids; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Tetradecanoylphorbol Acetate

2003
Cyclic AMP induces activation of extracellular signal-regulated kinases in HL-60 cells: role in cAMP-induced differentiation.
    Leukemia research, 2003, Volume: 27, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cell Differentiation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Isoquinolines; Lipopolysaccharide Receptors; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Phenotype; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Second Messenger Systems; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate

2003
Mixed lineage kinase 3 inhibits phorbol myristoyl acetate-induced DNA synthesis but not osteopontin expression in rat mesangial cells.
    Molecular and cellular biochemistry, 2002, Volume: 241, Issue:1-2

    Topics: Animals; Cell Division; DNA Replication; Enzyme Inhibitors; Flavonoids; Glomerular Mesangium; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mitogen-Activated Protein Kinases; Osteopontin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate

2002
Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells.
    The Journal of biological chemistry, 2003, Mar-28, Volume: 278, Issue:13

    Topics: Apoptosis; Butadienes; Concanavalin A; Enzyme Inhibitors; fas Receptor; Flavonoids; Humans; In Situ Nick-End Labeling; Jurkat Cells; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate

2003
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
    Oncogene, 2003, Feb-20, Volume: 22, Issue:7

    Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins

2003
Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.
    The Journal of biological chemistry, 2003, May-16, Volume: 278, Issue:20

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Apigenin; Blotting, Western; Calcimycin; Calcium; Casein Kinase II; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Genetic Vectors; Imidazoles; Indoles; Interferon-gamma; Macrophages; Maleimides; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors; Transcription, Genetic; Transcriptional Activation; Tyrphostins

2003
Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells.
    The Biochemical journal, 2003, Jun-15, Volume: 372, Issue:Pt 3

    Topics: Base Sequence; Binding Sites; Breast Neoplasms; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Parathyroid Hormone-Related Protein; Peptide Hormones; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Protein c-ets-2; Proto-Oncogene Proteins; Repressor Proteins; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured

2003
Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors.
    Endocrinology, 2003, Volume: 144, Issue:4

    Topics: Animals; Arsenites; Carcinogens; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Hepatocyte Growth Factor; Humans; Hypoglycemic Agents; Imidazoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sodium Compounds; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin

2003
Incadronate amplifies prostaglandin F2 alpha-induced vascular endothelial growth factor synthesis in osteoblasts. Enhancement of MAPK activity.
    The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21

    Topics: Alkyl and Aryl Transferases; Animals; Cell Line; Cloprostenol; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprost; Diphosphonates; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Flavonoids; Gene Expression; Indoles; Indomethacin; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Mice; Osteoblasts; Prostaglandins F, Synthetic; Protein Kinase C; RNA, Messenger; Sodium Fluoride; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2003, Volume: 135, Issue:1

    Topics: Animals; Animals, Newborn; Chickens; Enzyme Inhibitors; Flavonoids; Fluoresceins; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Neutrophils; Protein Kinase C; Pyridines; Respiratory Burst; Salmonella enteritidis; Signal Transduction; Staphylococcus aureus; Teichoic Acids; Tetradecanoylphorbol Acetate

2003
Interleukin-10-induced CCR5 expression in macrophage like HL-60 cells: involvement of Erk1/2 and STAT-3.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:8

    Topics: Cell Differentiation; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Interleukin-10; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Receptors, CCR5; RNA, Messenger; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators

2003
Lovastatin and phospholipase Cgamma regulate constitutive and protein kinase C dependent integrin mediated interactions of human T-cells with collagen.
    Cellular immunology, 2003, Volume: 223, Issue:1

    Topics: Cell Adhesion; Collagen Type IV; Flavonoids; Flow Cytometry; Herpesvirus 2, Saimiriine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrin alpha1beta1; Interferon-gamma; Lovastatin; MAP Kinase Kinase 1; Mevalonic Acid; Mitogen-Activated Protein Kinase Kinases; Phospholipase C gamma; Pravastatin; Protein Kinase C; Protein Serine-Threonine Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases

2003
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells

2003
Activation of P2X7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2.
    Cellular signalling, 2003, Volume: 15, Issue:12

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Astrocytes; Blotting, Northern; Blotting, Western; Brain; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Flavonoids; Gene Expression; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1

2003
Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells.
    Experimental eye research, 2004, Volume: 78, Issue:1

    Topics: Cell Line; Cell Transformation, Viral; Electric Impedance; Enzyme Activation; Enzyme Inhibitors; Epithelium, Corneal; Eye Proteins; Flavonoids; Humans; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Occludin; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Tight Junctions; Zonula Occludens-1 Protein

2004
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
    Oncogene, 2004, Mar-18, Volume: 23, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; Cell Movement; Chromones; Culture Media, Conditioned; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glioblastoma; Humans; Matrix Metalloproteinase Inhibitors; Mice; Mice, Nude; Morpholines; Neoplasms; Neovascularization, Pathologic; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A

2004
IFN-gamma gene expression in epithelial trophectoderm cells is linked to downregulation of the p44/p42 MAP kinase pathway.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2004, Volume: 24, Issue:1

    Topics: Animals; Blastocyst; Blotting, Western; Butadienes; Cell Polarity; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Interferon-gamma; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pregnancy; Swine; Tetradecanoylphorbol Acetate

2004
Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
    Oncogene, 2004, Mar-11, Volume: 23, Issue:10

    Topics: Cell Line, Tumor; Colonic Neoplasms; Dactinomycin; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; NF-kappa B; Promoter Regions, Genetic; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; TNF Receptor-Associated Factor 1; Transcription, Genetic

2004
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
    Journal of cellular biochemistry, 2004, Apr-01, Volume: 91, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles

2004
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
    Pharmacology, 2004, Volume: 71, Issue:2

    Topics: Animals; Blotting, Northern; Curcumin; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Flavonoids; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Pulmonary Artery; Pyridines; RNA, Messenger; Sheep; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha

2004
Fatty acids induce increased granulocyte macrophage-colony stimulating factor secretion through protein kinase C-activation in THP-1 macrophages.
    Lipids, 2004, Volume: 39, Issue:3

    Topics: Calcium Channel Blockers; Cell Line; Enzyme Activation; Fatty Acids; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Linoleic Acid; Macrophages; Mitogen-Activated Protein Kinase 3; Nifedipine; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Up-Regulation

2004
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid

2004
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
    Circulation research, 2004, Oct-01, Volume: 95, Issue:7

    Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate

2004
Retinol binding protein isolated from acute renal failure patients inhibits polymorphonuclear leucocyte functions.
    European journal of clinical investigation, 2004, Volume: 34, Issue:11

    Topics: Acute Kidney Injury; Apoptosis; Chemotaxis, Leukocyte; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Neutrophils; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines; Retinol-Binding Proteins; Tetradecanoylphorbol Acetate

2004
Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells.
    Experimental cell research, 2005, Jan-15, Volume: 302, Issue:2

    Topics: Animals; Blotting, Western; Carcinogens; Cell Communication; Cell Line; Cell Line, Tumor; Connexin 43; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fluorescent Dyes; Gap Junctions; Image Processing, Computer-Assisted; Indoles; Isoquinolines; Liver; Maleimides; MAP Kinase Signaling System; Phosphorylation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors

2005
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.
    Circulation research, 2005, Mar-04, Volume: 96, Issue:4

    Topics: Animals; Aorta; Blood Glucose; Cell Division; Cell Movement; Cells, Cultured; Constriction, Pathologic; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Femoral Artery; Flavonoids; Humans; Immediate-Early Proteins; Indoles; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; Maleimides; Mesylates; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Peroxidase; Protein Kinase C; Protein Kinase C beta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrroles; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Tunica Intima

2005
On the control of the hCYP11B2 gene expressing cytochrome P450 aldosterone synthase.
    Endocrine research, 2004, Volume: 30, Issue:4

    Topics: Angiotensin II; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Flavonoids; Gene Expression Regulation; Humans; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection

2004
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
    Biochemical and biophysical research communications, 2005, Apr-01, Volume: 329, Issue:1

    Topics: Anoikis; Apoptosis; Butadienes; Carbazoles; Cell Adhesion; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Indoles; Melanocytes; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection

2005
Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.
    Carcinogenesis, 2005, Volume: 26, Issue:6

    Topics: Adenocarcinoma; Agglutinins; Calcium-Binding Proteins; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclin D3; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Organ Specificity; Protein Kinase C; Proteins; Receptors, Cell Surface; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Trefoil Factor-1; Tumor Suppressor Proteins

2005
Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells.
    The Journal of veterinary medical science, 2005, Volume: 67, Issue:3

    Topics: Animals; Blotting, Western; Cell Communication; Cell Differentiation; Connexin 43; Connexins; Flavonoids; Gap Junction beta-1 Protein; Gap Junctions; Imidazoles; Neurons; Pyridines; Rats; Stem Cells; Tetradecanoylphorbol Acetate

2005
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
    British journal of pharmacology, 2005, Volume: 145, Issue:4

    Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases

2005
Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent.
    Leukemia research, 2005, Volume: 29, Issue:8

    Topics: Antioxidants; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase; Gene Expression Regulation, Leukemic; Humans; Monocytes; Phosphorylation; Protein Kinase C; Reactive Oxygen Species; Retinoblastoma Protein; RNA, Messenger; S Phase; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors

2005
Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.
    Nature cell biology, 2005, Volume: 7, Issue:8

    Topics: 14-3-3 Proteins; beta Catenin; Cadherins; Caveolae; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Cytoskeletal Proteins; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; HeLa Cells; Humans; MAP Kinase Signaling System; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Prohibitins; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; raf Kinases; ras Proteins; Repressor Proteins; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection

2005
Glucose represses connexin36 in insulin-secreting cells.
    Journal of cell science, 2005, Nov-15, Volume: 118, Issue:Pt 22

    Topics: Animals; Base Sequence; Cell Line, Tumor; Colforsin; Connexins; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Down-Regulation; Flavonoids; Gap Junction delta-2 Protein; Glucose; Humans; Insulin-Secreting Cells; Isoquinolines; Mitogen-Activated Protein Kinases; Nifedipine; Promoter Regions, Genetic; Rats; Response Elements; RNA, Messenger; Sequence Deletion; Sulfonamides; Tetradecanoylphorbol Acetate

2005
PKC alpha-dependent regulation of the IGF1 receptor in adult and embryonic rat cardiomyocytes.
    Molecular and cellular biochemistry, 2005, Volume: 275, Issue:1-2

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; Embryo, Mammalian; Enzyme Activation; Flavonoids; Gene Expression Regulation, Enzymologic; Heart Ventricles; Indoles; Insulin-Like Growth Factor I; Kinetics; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Protein Biosynthesis; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate

2005
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:6

    Topics: Animals; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelin-Converting Enzymes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Kinase 1; Metalloendopeptidases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Receptor, Endothelin A; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transfection

2006
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
    Oncogene, 2006, May-18, Volume: 25, Issue:21

    Topics: Adamantane; Anisomycin; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cinnamates; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinase 1; Mutagenesis, Site-Directed; Nuclear Receptor Subfamily 4, Group A, Member 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription Factors

2006
Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells.
    Experimental cell research, 2006, Jul-15, Volume: 312, Issue:12

    Topics: Aminocaproic Acid; Cell Movement; Colonic Neoplasms; Culture Media, Serum-Free; Enzyme Inhibitors; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibrinolysin; Flavonoids; Hepatocyte Growth Factor; HT29 Cells; Humans; Integrin beta1; Pertussis Toxin; Phosphorylation; Plasminogen; Plasminogen Activator Inhibitor 1; Protein Kinase C-alpha; Pyrazoles; Pyrimidines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator

2006
Activation of protein kinase C delta induces growth arrest in NPA thyroid cancer cells through extracellular signal-regulated kinase mitogen-activated protein kinase.
    Thyroid : official journal of the American Thyroid Association, 2006, Volume: 16, Issue:4

    Topics: Adenoviridae; Breast Neoplasms; Carcinoma; Carcinoma, Papillary; Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase; Humans; Protein Kinase C-delta; Proto-Oncogene Proteins B-raf; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Transfection

2006
Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:9

    Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Anthracenes; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; Enzyme Induction; Flavonoids; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate

2006
On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells.
    Pancreas, 2006, Volume: 33, Issue:2

    Topics: Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Flavonoids; G2 Phase; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate

2006
[Protective effect of protein kinase C and mitogen-activated protein kinases and its mechanism in liver ischemic preconditioning].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2006, Volume: 26, Issue:8

    Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Benzophenanthridines; Enzyme Inhibitors; Flavonoids; Ischemic Preconditioning; Liver; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tetradecanoylphorbol Acetate

2006
Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line.
    Journal of cellular biochemistry, 2007, Mar-01, Volume: 100, Issue:4

    Topics: Blotting, Western; Butadienes; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indoles; Intercellular Adhesion Molecule-1; Leukemia, Myeloid; Maleimides; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Nitriles; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Sulfones; Tetradecanoylphorbol Acetate

2007
Alpha1-adrenergic receptor stimulation induces the expression of receptor activator of nuclear factor kappaB ligand gene via protein kinase C and extracellular signal-regulated kinase pathways in MC3T3-E1 osteoblast-like cells.
    Archives of oral biology, 2007, Volume: 52, Issue:8

    Topics: 3T3 Cells; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Indoles; Maleimides; Mice; Osteoblasts; Phenylephrine; Prazosin; Propranolol; Protein Kinase C; Receptor Activator of Nuclear Factor-kappa B; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Yohimbine

2007
Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts.
    Journal of dermatological science, 2007, Volume: 46, Issue:2

    Topics: Animals; Cells, Cultured; Dermis; Dose-Response Relationship, Drug; Enzyme Activation; Epidermis; Fibroblasts; Flavonoids; Humans; Indoles; Interleukin-6; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Phosphorylcholine; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Rabbits; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Wound Healing

2007
LIF upregulates expression of NK-1R in NHBE cells.
    Mediators of inflammation, 2006, Volume: 2006, Issue:5

    Topics: Animals; Asthma; Base Sequence; Bronchi; Cells, Cultured; Epithelial Cells; Flavonoids; Humans; Janus Kinases; Leukemia Inhibitory Factor; Male; MAP Kinase Signaling System; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Recombinant Proteins; RNA, Small Interfering; STAT Transcription Factors; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Tyrphostins; Up-Regulation

2006
[Influence of signal transduction modulators on the secretory function of T lymphocytes in severely scalded mice and its mechanism].
    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 2006, Volume: 22, Issue:6

    Topics: Animals; Benzoquinones; Burns; Calcimycin; Calcium; Cells, Cultured; Female; Flavonoids; Interleukin-10; Interleukin-2; Lactams, Macrocyclic; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Rifabutin; Signal Transduction; Spleen; T-Lymphocytes; Tetradecanoylphorbol Acetate

2006
ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
    Toxicology and applied pharmacology, 2007, May-15, Volume: 221, Issue:1

    Topics: Astrocytes; Blotting, Western; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Flavonoids; Humans; Indoles; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Pyrimidines; Quinazolines; Signal Transduction; Spheroids, Cellular; src-Family Kinases; Stem Cells; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins

2007
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.
    Journal of cellular physiology, 2007, Volume: 212, Issue:3

    Topics: Adenylyl Cyclases; Aprotinin; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activators; Epidermal Growth Factor; Fibroblast Growth Factors; Flavonoids; Humans; Indoles; Insulin; Iodine; Iodine Radioisotopes; Maleimides; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Plasminogen Inactivators; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator

2007
Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell.
    Cancer investigation, 2008, Volume: 26, Issue:1

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; Immunohistochemistry; p21-Activated Kinases; Phorbol Esters; Proliferating Cell Nuclear Antigen; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53

2008
The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells.
    BMC cancer, 2008, Sep-30, Volume: 8

    Topics: Biomarkers, Tumor; Carcinogens; Carrier Proteins; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Progression; Enzyme Inhibitors; Fatty Acid-Binding Protein 7; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoenzyme Techniques; Melanoma; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; Nevus, Pigmented; Oligonucleotide Array Sequence Analysis; Prognosis; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Survival Rate; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Suppressor Proteins

2008
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
    Autonomic & autacoid pharmacology, 2009, Volume: 29, Issue:1-2

    Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin

2009
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
    The Journal of biological chemistry, 2009, Sep-25, Volume: 284, Issue:39

    Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate

2009
Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors.
    The Journal of biological chemistry, 2010, Feb-12, Volume: 285, Issue:7

    Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromones; Computational Biology; Cyclin-Dependent Kinase Inhibitor p27; Electrophoretic Mobility Shift Assay; Flavonoids; Flow Cytometry; Humans; MAP Kinase Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Multimerization; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2010
Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways.
    Cancer letters, 2010, Sep-28, Volume: 295, Issue:2

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate

2010
GH3B6 pituitary tumor cell proliferation is mediated by PKCalpha and PKCepsilon via ERK 1/2-dependent pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 26, Issue:2

    Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Flavonoids; Flow Cytometry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pituitary Neoplasms; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2010
TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.
    Free radical research, 2012, Volume: 46, Issue:5

    Topics: Butadienes; Cell Differentiation; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Indoles; Macrophages; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NADPH Oxidases; Nitriles; Protein Kinase C; Reactive Oxygen Species; Superoxide Dismutase; Tetradecanoylphorbol Acetate

2012
Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Anthracenes; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Ginsenosides; Hep G2 Cells; Humans; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1

2012
Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells.
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2012, Volume: 22, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Chromones; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Female; Flavonoids; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; S Phase; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays

2012
Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells.
    Archives of toxicology, 2013, Volume: 87, Issue:5

    Topics: Adenocarcinoma; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cell Movement; Cell Survival; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Activation; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Gene Silencing; Heme Oxygenase-1; Humans; Indoles; Maleimides; Matrix Metalloproteinase 9; MCF-7 Cells; Neoplasm Invasiveness; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin

2013
Skp2 regulates subcellular localization of PPARγ by MEK signaling pathways in human breast cancer.
    International journal of molecular sciences, 2013, Aug-09, Volume: 14, Issue:8

    Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Female; Flavonoids; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; MCF-7 Cells; Nitriles; Phosphorylation; PPAR gamma; Protein Kinase Inhibitors; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; S-Phase Kinase-Associated Proteins; Tetradecanoylphorbol Acetate

2013
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases

2014
Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.
    Cellular and molecular life sciences : CMLS, 2015, Volume: 72, Issue:4

    Topics: Animals; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 2 Subunit; Down-Regulation; Flavonoids; Humans; K562 Cells; Liver; Megakaryocytes; Mice; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoprotein IIb; Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Up-Regulation

2015
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:6

    Topics: Anthracenes; Apoptosis; bcl-X Protein; Caffeic Acids; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Regulation, Developmental; Hematopoiesis; Humans; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate

2014
A cell-based sensor of fluid shear stress for microfluidics.
    Lab on a chip, 2015, Mar-21, Volume: 15, Issue:6

    Topics: Animals; Biosensing Techniques; Early Growth Response Protein 1; Flavonoids; Lab-On-A-Chip Devices; Mice; NIH 3T3 Cells; Shear Strength; Stress, Mechanical; Tetradecanoylphorbol Acetate; Up-Regulation

2015
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: Antioxidants; Butyric Acid; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Flavonoids; Gene Expression Regulation; Herpesvirus 8, Human; Host-Pathogen Interactions; Humans; Hydrogen Peroxide; Lymphocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphorylation; Quercetin; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Virus Activation; Virus Replication

2017
Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway.
    Molecular medicine reports, 2017, Volume: 16, Issue:5

    Topics: Animals; Butadienes; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Protein Kinase C-alpha; Pulmonary Artery; Rats; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Up-Regulation

2017
Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling.
    International journal of molecular sciences, 2017, Dec-21, Volume: 19, Issue:1

    Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coumarins; Drugs, Chinese Herbal; Female; Flavonoids; HeLa Cells; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Protein Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Uterine Cervical Neoplasms

2017
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:2

    Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2019