tetradecanoylphorbol acetate has been researched along with leukotriene b4 in 188 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (28.19) | 18.7374 |
| 1990's | 109 (57.98) | 18.2507 |
| 2000's | 23 (12.23) | 29.6817 |
| 2010's | 3 (1.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCaffrey, PG; Minowada, J; Oghiso, Y; Shibata, Y; Volkman, A | 1 |
| Jones, SK | 1 |
| Allen, B; Dryden, P; Merali, T; Reaney, A; Salari, H; Wong, S | 1 |
| Bach, MK; Brashler, JR; Petzold, EN; Sanders, ME | 1 |
| Kuroda, T; Morita, I; Murota, S; Suda, N | 1 |
| Kishikawa, K; Maruyama, T; Miyamoto, T; Seo, R; Tateishi, N; Toda, M | 1 |
| Friedl, P; König, B; König, W; Pedersen, SS | 1 |
| Lonigro, AJ; Sprague, RS; Stephenson, AH | 1 |
| Elsner, J; Emmendörffer, A; Lohmann-Matthes, ML; Roesler, J; Welte, K; Zeidler, C | 1 |
| Becker, EL; Huang, CK; Molski, TF; Sha'afi, RI; Stevens, T; Yamazaki, M | 1 |
| Habenicht, AJ; Kiesel, L; Przylipiak, AF; Przylipiak, MS; Runnebaum, B | 1 |
| Hilger, RA; Kasimir, S; König, W; Schönfeld, W | 1 |
| Gay, JC; Murray, JJ | 1 |
| Samuelsson, J | 2 |
| Balazovich, K; McNish, RW; Peters-Golden, M; Sporn, PH | 1 |
| Berkow, RL; Dodson, RW | 1 |
| Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Abrahamsen, TG; Bonvini, E; Brando, C; Hansen, M; Hoffman, T; Lee, YL; Lizzio, EF; Puri, J; Taplits, M; Tripathi, AK | 1 |
| Elstad, MR; McIntyre, TM; Prescott, SM; Zimmerman, GA | 1 |
| Atluru, D; Atluru, S; Jackson, TM | 1 |
| Habermehl, GG; Meier, B; Radeke, HH; Resch, K; Selle, S; Sies, H | 1 |
| Creba, J; Pollock, K | 1 |
| Nourshargh, S; Williams, TJ | 1 |
| Lerner, R; Lindström, P; Palmblad, J | 2 |
| Fish, JE; Flynn, JT; Peters, SP; Spannhake, EW; Yoss, EB | 1 |
| Jacobson, DP; O'Flaherty, JT; Redman, JF | 2 |
| Masuda, Y; Takanaka, K; Taniguchi, K | 1 |
| Caulfield, T; Fiore, S; Kataoka, H; Nicolaou, KC; Serhan, CN | 1 |
| Nolfo, R; Rankin, JA | 1 |
| Furue, M; Katz, SI; Kawakami, T; Kawakami, Y | 1 |
| DiPersio, JF; Gasson, JD; Golde, DW | 1 |
| Becker, W; Borgeat, P; Gyllenhammar, H; Hafström, I; Palmblad, J; Ringertz, B; Svensson, J | 1 |
| Cott, GR; Voelkel, NF; Westcott, JY | 1 |
| Tai, HH; Tanizawa, H | 1 |
| Tai, HH; Yamazaki, H | 1 |
| McCaffrey, PG; Oghiso, Y; Sato, H; Shibata, Y | 1 |
| Gaudry, M; Hakim, J; Marquetty, C | 1 |
| Atkins, PC; Moskovitz, AR; Taylor, MB; von Allmen, C; Zweiman, B | 1 |
| Bonak, VA; Caon, AC; Gaudry, M; Gilbert, C; Huang, CK; McColl, SR; Naccache, PH; Umezawa, K | 1 |
| Fletcher, MP; Ziboh, VA | 1 |
| Keller, HU | 1 |
| Carey, F; Forder, RA; Hoult, JR; Moroney, MA | 1 |
| Aussel, C; Fehlmann, M | 1 |
| Bonvini, E; Hoffman, T; Jennings, MK; Lizzio, EF; Marshall, LA; Ting, A | 1 |
| Danner, RL; Doerfler, ME; Parrillo, JE; Shelhamer, JH | 1 |
| Gyllenhammar, H | 1 |
| Brown, KE; Derse, CP; Freeland, HS; Peters, SP; Schleimer, RP | 1 |
| Hamasaki, T; Kobayashi, M; Sakano, T; Sakura, N; Ueda, K; Usui, T | 1 |
| Berg, EL; Butcher, EC; Jutila, MA; Kishimoto, TK | 1 |
| Jacobson, D; O'Flaherty, JT | 1 |
| Chi, EY; Goodman, RB; Martin, TR; Matthay, MA; Pistorese, BP | 1 |
| Berg, EL; Butcher, EC; Jutila, MA; Rott, L | 1 |
| Keller, HU; Niggli, V; Zimmermann, A | 1 |
| D'Alesandro, MM; Gruber, DF; Walden, TL | 1 |
| Brom, J; König, W | 1 |
| Bier, JW; Friedman, L; Gaines, DW; Hines, FA; Raybourne, RB | 1 |
| Betts, WH; Cleland, LG; Hurst, NP; McColl, SR | 1 |
| McIntyre, TM; Prescott, SM; Reinhold, SL; Zimmerman, GA | 1 |
| Coffey, JW; Fiedler-Nagy, C; Georgiadis, A; Hope, WC; Welton, AF; Wittreich, BH | 1 |
| Fujie, A; Hamasaki, T; Harada, Y; Sakano, T; Taniguchi, H; Ueda, K | 1 |
| Gonzalez-Crussi, F; Henderson, S; Hsueh, W | 1 |
| Jacobson, D; O'Flaherty, JT; Redman, J | 1 |
| Albertine, KH; Gee, MH; Gottlieb, JE; Peters, SP | 1 |
| König, W; Raulf, M | 1 |
| Grinstein, S; Nasmith, PE | 1 |
| Caon, AC; Faucher, N; McColl, SR; Naccache, PH | 1 |
| Brom, J; König, W; Schönfeld, W | 1 |
| Glomset, JA; Goerig, M; Habenicht, AJ; Kommerell, B; Nastainczyk, W; Rothe, DE; Salbach, P; Zeh, W | 1 |
| Agrawal, DK; Tamura, N; Townley, RG | 1 |
| Justen, JM; Sam, LM; Smith, RJ | 1 |
| Borgeat, P; Molski, TF; Naccache, PH; Sha'afi, RI; White, JR | 1 |
| Becker, EL; Feinstein, MB; Molski, TF; Munoz, JJ; Naccache, PH; Sha'afi, RI; Shefcyk, J; Volpi, M; Yassin, R | 1 |
| Feinstein, MB; Molski, TF; Naccache, PH; Sha'afi, RI; Shefcyk, J; Tao, W; Volpi, M; White, JR; Yassin, R | 1 |
| Chan, CC; Duhamel, L; Ford-Hutchison, A | 1 |
| Huang, CK; Molski, TF; Naccache, PH; Sha'afi, RI | 1 |
| Bender, P; Chi-Rosso, G; Crooke, ST; Hoffman, K; Miller, J; Mong, S; Razgaitis, KA | 1 |
| Niwa, Y; Ohashi, T; Ozaki, Y | 1 |
| Gasson, JC; Golde, DW; Kwan, L; Weisbart, RH | 1 |
| Cleland, LG; Hurst, NP; McColl, SR | 1 |
| Nishihira, J; O'Flaherty, JT | 1 |
| McIver, DJ; Paterson, NA; Schurch, S | 1 |
| Giedd, KN; Haines, KA; Korchak, HM; Rich, AM; Weissmann, G | 1 |
| Becker, EL; Kanaho, Y; Matsumoto, T; Molski, TF; Sha'afi, RI | 1 |
| Henderson, WR; Liles, WC; Meier, KE | 1 |
| Molski, TF; Sha'afi, RI | 1 |
| Baggiolini, M; Deranleau, DA; von Tscharner, V; Wymann, MP | 1 |
| Thomson, DM | 1 |
| Borgeat, P; Molski, TF; Naccache, PH; Sha'afi, RI | 1 |
| Lees, CJ; McCall, CE; O'Flaherty, JT; Shewmake, T; Thomas, MJ; Wykle, RL | 1 |
| Hammett, MJ; Love, SH; McCall, CE; O'Flaherty, JT; Shewmake, TB; Thomas, MJ; Wykle, RL | 1 |
| Hsueh, W; Sun, FF | 1 |
| Austen, KF; Corey, EJ; Lee, CW; Lewis, RA; Mehrotra, M; Tauber, AI | 1 |
| Minakami, S; Sumimoto, H; Takeshige, K | 1 |
| Clark, JD; Doerfler, ME; Elsbach, P; Weiss, J | 1 |
| Dewald, B; Fey, MF; Meier, RW; Niklaus, G; Tobler, A | 1 |
| Alcaraz, MJ; Ferrándiz, ML; Gil, B; Payá, M; Rovirosa, J; San-Martin, A; Sanz, MJ; Terencio, MC; Ubeda, A | 1 |
| Lloret, S; Moreno, JJ | 1 |
| Edwards, SW; Stringer, RE | 1 |
| Goetzl, EJ; Shames, RS | 1 |
| Bratt, J; Lerner, R; Palmblad, J; Ringertz, B | 1 |
| Colotta, F; Fadlon, EJ; Mantovani, A; Matteucci, C; Orlando, S; Sozzani, S | 1 |
| Araki, R; Komada, T; Naka, M; Nakatani, K; Shima, T; Tanaka, T | 1 |
| Djuric, SW; Isakson, PC; Rao, TS; Yu, SS | 1 |
| Abe, T; Matsuda, K; Nagai, H; Omata, T; Segawa, Y; Yoshida, K | 1 |
| Allen, PG; Brady, HR; Janmey, PA; Matsubara, M; Serhan, CN; Takata, S | 1 |
| Barnes, PJ; Dent, G; Gustmann, H; Perkins, RS; Rabe, KF | 1 |
| Blackburn, WD; Chatham, WW; Turkiewicz, A | 1 |
| Csuk-Glänzer, BI; Fürstenberger, G; Keppler, D; Marks, F | 1 |
| Jiang, H; Kato, R; Yamamoto, S | 1 |
| Guidot, DM; Repine, JE; Repine, MJ; Westcott, JY | 1 |
| Franson, RC; Rosenthal, MD | 1 |
| Joshi, SN; Lonigro, AJ; Sprague, RS; Stephenson, AH | 1 |
| Arfors, KE; Berger, E; Lundgren-Akerlund, E; Olofsson, AM | 1 |
| Javors, MA; Olson, MS; Zhou, W | 1 |
| Jacobs, AA; Lederer, ED; McLeish, KR | 1 |
| Connelly, PA; Farrell, CA; Richard, S; Shaw, AS; Showell, HJ | 1 |
| Marshall, CJ; Saklatvala, J; Thompson, HL | 1 |
| Closa, D; Gelpí, E; Hotter, G; Ramis, I; Roselló-Catafau, J | 1 |
| Ciabattoni, G; Currò, D; Montuschi, P; Navarra, P; Parente, L; Preziosi, P; Tringali, G | 1 |
| Ali, A; Evans, JF; Kargman, S; Nicholson, DW; Vaillancourt, JP | 1 |
| Frojmovic, MM; Rochon, YP | 1 |
| Barsky, OA; Galkina, SI; Margolis, LB; Sud'ina, GF | 1 |
| Aaes, H; Ahnfelt-Rønne, I; Skak-Nielsen, T | 1 |
| Becker, I; Huber, W; Peskar, BM; Schenck, U; Schepp, W; Trautmann, M | 1 |
| Jarvis, M; Morrissey, MM; Rediske, J | 1 |
| De Groot, H; Gyenes, M | 1 |
| Fiore, S; Reardon, EM; Romano, M; Serhan, CN | 1 |
| Damtew, B; Goldsmith, G; Spagnuolo, PJ; Tserng, KY | 1 |
| Mizuno, S; Ohoka, T; Shibata, M; Suzuki, K | 1 |
| Heimburger, M; Lerner, R; Palmblad, J | 1 |
| Atluru, D; Gudapaty, S; O'Donnell, MP; Woloschak, GE | 1 |
| Edenius, C; Lindgren, JA; Sjölinder, M; Tornhamre, S; Werga, P | 1 |
| Alcaraz, MJ; De Giulio, A; De Rosa, S; Gil, B; Payá, M; Sanz, MJ; Terencio, MC | 1 |
| Bhakar, A; Gravel, S; Gravelle, F; MacLeod, RJ; Powell, WS | 1 |
| Dudhane, A; Godfrey, HP; Lin, KT; Wong, PY | 1 |
| Damais, C; Delfraiss, JF; Dugas, B; Dugas, N; Kolb, JP; Yamaoka, K | 1 |
| Forn, J; García-Rafanell, J; Merlos, M; Vericat, ML | 1 |
| Obata, Y; Oda, M; Yamamoto, N; Yokota, K | 1 |
| Bachmann, H; Moser, U; Pantze, M; Raederstorff, D | 1 |
| Abe, M; Domae, M; Furukawa, T; Hara, N; Kudo, I; Kuwata, H; Matsuki, H; Mitsuyama, T; Nakanishi, Y | 1 |
| Bald, A; Cassatella, MA; McDonald, PP | 1 |
| Babina, M; Feller, G; Henz, BM; Weber, S | 1 |
| Patarroyo, M; Salcedo, R; Wasserman, K | 1 |
| Joe, B; Lokesh, BR | 1 |
| Anderson, J; Chen, E; Shamsuddin, M; Smith, LJ | 1 |
| Badger, AM; Breton, J; Chabot-Fletcher, M; Griswold, DE; Martin, LD | 1 |
| Denizot, Y; Desplat, V; Dulery, C; Praloran, V; Trimoreau, F | 1 |
| al-Hage, M; Ezeamuzie, CI; Nwankwoala, RN | 1 |
| Cai, X; Eckman, J; Hussoin, MS; Hwang, SB; Ip, SH; Killian, DB; Libertine-Garahan, L; Qian, C; Scannell, RT; Shen, TY; Yaeger, D; Yeh, CG | 1 |
| Puigneró, V; Queralt, J; Turull, A | 1 |
| Aiyama, R; Hashimoto, S; Matsuzaki, T; Yamazaki, R; Yokokura, T | 1 |
| Galkina, SI; Margolis, LB; Sud'ina, GF; Ullrich, V | 1 |
| Burke-Gaffney, A; Hellewell, PG | 1 |
| Budhu, S; Cao, L; El Khoury, J; Hoffman, S; Loike, JD; Marcantonio, EE; Silverstein, SC; Yednock, TA | 1 |
| Akasaki, T; Koga, H; Sumimoto, H | 1 |
| Cunha, FQ; Hothersall, J; Noronha-Dutra, A; Teixeira, MM | 1 |
| Arfors, KE; David, G; Dedio, J; Flodgaard, H; Herwald, H; Linde, V; Lundgren-Akerlund, E; Müller-Esterl, W; Olofsson, AM; Rygaard, J; Vestberg, M | 1 |
| Ali, H; Haribabu, B; Pridgen, BC; Richardson, RM; Snyderman, R; Zhelev, DV | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Dugas, B | 1 |
| Blodgett, JL; Bloodworth, RC; McManus, LM; Pinckard, RN; Prihoda, TJ | 1 |
| Hanson, AJ; Quinn, MT; Siemsen, DW; Swain, SD | 1 |
| Haynes, J; Obiako, B | 1 |
| Bankers-Fulbright, JL; Gleich, GJ; Kita, H; O'Grady, SM | 1 |
| Martínez, AM; Montoya, CJ; Olarte, JC; Velilla, PA | 1 |
| Cerdá-Nicolás, M; Giner, RM; Giner-Larza, EM; Máñez, S; Prieto, JM; Recio, MC; Ríos, JL | 1 |
| Eilertsen, KE; Olsen, JO; Østerud, B | 1 |
| Giner, RM; Máñez, S; Recio, MC; Ríos, JL; Sala, A; Schinella, GR | 1 |
| Kamei, C; Ogawa, M; Sugimoto, Y; Tai, N | 1 |
| Clarke, C; Clinkenbeard, K; Cudd, L | 1 |
| Moreno, JJ | 1 |
| Argentieri, D; Cavender, D; Hou, C; Kirchner, T; Matheis, M; Singer, M | 1 |
| Kim, CH; Kim, HM; Park, SY; Park, WH | 1 |
| Bonucelli, M; Cerdá-Nicolás, M; Giner, RM; Máñez, S; Orsi, C; Prieto, M; Recio, MC; Ríos, JL | 1 |
| Delgado, R; Delporte, C; García, D; Garrido, G; González, D; Lemus, Y; Lodeiro, L; Núñez-Sellés, AJ; Quintero, G | 1 |
| Kashiwagi, S; Kikuta, Y; Nakata, K; Okada, K; Tani, K; Yamashita, Y | 1 |
| Giner, RM; Hernández, V; Máñez, S; Recio, MC; Ríos, JL | 2 |
| Dushenkov, S; Ghai, G; Ho, CT; Huang, MT; Liu, Y; Lo, CY; Ramji, D | 1 |
| Delgado, R; Delporte, C; Garrido, G; González, D; Lemus, Y | 1 |
| Albertsen, J; Eriksen, HN; Hoffmann, EK; Lambert, IH; Mollerup, J; Wulff, T | 1 |
| Alexander, JS; Carpenter, AC | 1 |
| Choi, Y; Hwang, JK; Kim, MS | 1 |
| Abidi, L; Avesi, L; Faizi, S; Farooq, AD; Mirza, T; Naqvi, S; Siddiqui, F | 1 |
| Golenkina, EA; Livenskyi, AD; Romanova, YM; Sokolov, AV; Sud'ina, GF; Viryasova, GM | 1 |
2 review(s) available for tetradecanoylphorbol acetate and leukotriene b4
| Article | Year |
|---|---|
A structure-function approach to investigate the role of inflammatory cells and mediators in the production of acute lung injury.
Topics: Acute Disease; Animals; Humans; Inflammation; Leukotriene B4; Neutrophils; Respiratory Distress Syndrome; Sheep; SRS-A; Tetradecanoylphorbol Acetate; Vasoconstriction | 1988 |
Impaired activation of phospholipase D in polycythaemia vera-implications for the pathogenesis of the disease?
Topics: Enzyme Activation; Humans; Inositol 1,4,5-Trisphosphate; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidative Stress; Phospholipase D; Platelet Activating Factor; Polycythemia Vera; Tetradecanoylphorbol Acetate | 1995 |
1 trial(s) available for tetradecanoylphorbol acetate and leukotriene b4
| Article | Year |
|---|---|
Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo.
Topics: Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclooxygenase Inhibitors; Dexamethasone; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Macrophage Activation; Macrophages; Phosphatidylcholines; Phosphatidylinositols; Pulmonary Alveoli; Radioimmunoassay; Tetradecanoylphorbol Acetate; Thromboxane B2; Zymosan | 1990 |
185 other study(ies) available for tetradecanoylphorbol acetate and leukotriene b4
| Article | Year |
|---|---|
Regulation of phospholipase A2 activation and arachidonic acid metabolism in an interleukin-3-dependent macrophage-like cell line.
Topics: Animals; Arachidonic Acids; Biological Transport; Bone Marrow; Bone Marrow Cells; Calcimycin; Calcium; Cell Fractionation; Cells, Cultured; Dinoprostone; Eicosanoids; Enzyme Activation; Hydrogen-Ion Concentration; Interleukin-3; Leukotriene B4; Macrophages; Mice; Mice, Inbred CBA; Phospholipases A; Phospholipases A2; Protein Kinase C; Tetradecanoylphorbol Acetate; Tritium | 1992 |
The effects of hormonal and other stimuli on cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: their possible role in the induction of cutaneous lupus lesions.
Topics: Antigens, Surface; Autoantigens; Cells, Cultured; Cholera Toxin; Cytokines; Estradiol; Female; Humans; Hydrogen Peroxide; Keratinocytes; Leukotriene B4; Lupus Erythematosus, Systemic; Ribonucleoproteins; RNA, Small Cytoplasmic; Sex Factors; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1992 |
Protein kinase C impairs the coupling of the GTP-binding protein to LTB4 receptor in neutrophil.
Topics: Animals; Binding, Competitive; Enzyme Activation; GTP-Binding Proteins; Guanine Nucleotides; Leukotriene B4; Neutrophils; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Swine; Tetradecanoylphorbol Acetate | 1992 |
Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Topics: Alkaloids; Androstadienes; Carbazoles; Eosinophils; Humans; Immunoglobulin G; Indole Alkaloids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin; Zymosan | 1992 |
Priming effects of leukotriene B4 on endothelial cell injury induced by TPA-activated leukocytes.
Topics: Cell Adhesion; Cells, Cultured; Cytotoxicity Tests, Immunologic; Endothelium, Vascular; Humans; Leukotriene B4; Luminescent Measurements; Neutrophils; Oxygen; Tetradecanoylphorbol Acetate | 1992 |
ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions.
Topics: Animals; Calcium; Cell Aggregation; Chemotaxis, Leukocyte; Complement C5a; Cytoplasmic Granules; Guinea Pigs; Humans; Inflammation; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Neutrophils; Phenylpropionates; Receptors, Immunologic; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate | 1992 |
Alginate--its role in neutrophil responses and signal transduction towards mucoid Pseudomonas aeruginosa bacteria.
Topics: Alginates; Cystic Fibrosis; Glucuronic Acid; Glycosaminoglycans; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hexuronic Acids; Humans; Leukotriene B4; Luminescent Measurements; Neutrophils; Polysaccharides, Bacterial; Protein Kinase C; Pseudomonas aeruginosa; Signal Transduction; Tetradecanoylphorbol Acetate | 1992 |
OKY-046 prevents increases in LTB4 and pulmonary edema in phorbol ester-induced lung injury in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate 5-Lipoxygenase; Cardiac Output; Dogs; Extravascular Lung Water; Leukocyte Count; Leukotriene B4; Male; Methacrylates; Oxygen; Pulmonary Edema; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Thromboxanes | 1992 |
Altered function and surface marker expression of neutrophils induced by rhG-CSF treatment in severe congenital neutropenia.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Surface; Chemotaxis, Leukocyte; Complement C5a; Fluorescein-5-isothiocyanate; Granulocyte Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunoglobulin G; In Vitro Techniques; Interleukin-8; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutropenia; Neutrophils; Receptors, Fc; Receptors, Formyl Peptide; Receptors, IgG; Receptors, Immunologic; Recombinant Proteins; Reference Values; Tetradecanoylphorbol Acetate | 1992 |
Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils.
Topics: Alkaloids; Calcium; Cell Membrane; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Neutrophils; Platelet Activating Factor; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Production of leukotrienes in gonadotropin-releasing hormone-stimulated pituitary cells: potential role in luteinizing hormone release.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Down-Regulation; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Leukotriene B4; Leukotriene E4; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, LHRH; Signal Transduction; SRS-A; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Analysis of leukotriene B4 metabolism in human promyelocytic HL-60 cells.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Humans; Leukemia, Promyelocytic, Acute; Leukotriene B4; Luminescent Measurements; Nitroblue Tetrazolium; Oxidation-Reduction; Oxidoreductases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Differential effects of propranolol on responses to receptor-dependent and receptor-independent stimuli in human neutrophils.
Topics: Calcium; Humans; In Vitro Techniques; Ionomycin; Isomerism; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Platelet Activating Factor; Propranolol; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Neutrophil function in polycythemia vera.
Topics: Humans; Leukotriene B4; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Polycythemia Vera; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism.
Topics: Alkaloids; Animals; Arachidonic Acids; Basal Metabolism; Calcimycin; Cells, Cultured; Enzyme Activation; Female; Leukotriene B4; Macrophages, Alveolar; Peritoneum; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Tyrosine-specific protein phosphorylation during activation of human neutrophils.
Topics: Blotting, Western; Calcimycin; Cytosol; Humans; In Vitro Techniques; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Phosphotyrosine; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro. Synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Concanavalin A; Eicosanoids; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotriene B4; Monocytes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C regulates the synthesis of platelet-activating factor by human monocytes.
Topics: Binding Sites; Calcimycin; Diglycerides; Enzyme Activation; Humans; Kinetics; Leukotriene B4; Monocytes; Opsonin Proteins; Phagocytosis; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells.
Topics: Calcimycin; Cells, Cultured; Genistein; Humans; Interleukin-2; Isoflavones; Leukocytes, Mononuclear; Leukotriene B4; Lymphocyte Activation; Phytohemagglutinins; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate | 1991 |
Human fibroblasts release low amounts of reactive oxygen species in response to the potent phagocyte stimulants, serum-treated zymosan, N-formyl-methionyl-leucyl-phenylalanine, leukotriene B4 or 12-O-tetradecanoylphorbol 13-acetate.
Topics: Electron Spin Resonance Spectroscopy; Fibroblasts; Free Radicals; Humans; Hydrogen Peroxide; Leukotriene B4; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Nitroblue Tetrazolium; Oxidation-Reduction; Oxygen; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Leukotriene D4 induced calcium changes in U937 cells may utilize mechanisms additional to inositol phosphate production that are pertussis toxin insensitive but are blocked by phorbol myristate acetate.
Topics: Calcium; Cell Line; Humans; Inositol Phosphates; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; SRS-A; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.
Topics: Animals; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Degranulation; Complement C5a; Inflammation; Interleukin-1; Interleukin-8; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Rabbits; Receptors, Leukocyte-Adhesion; Recombinant Proteins; Skin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Zymosan | 1990 |
Leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils.
Topics: Cell Adhesion; Endothelium, Vascular; Humans; In Vitro Techniques; Leukotriene B4; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Thrombin; Time Factors | 1990 |
Mechanisms involved in the bidirectional effects of protein kinase C activators on neutrophil responses to leukotriene B4.
Topics: Calcium; Down-Regulation; Enzyme Activation; Humans; In Vitro Techniques; Ionomycin; Leukotriene B4; Neutrophils; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Action sites of antiallergic drugs on human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Histamine Antagonists; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils.
Topics: Antigens, CD; Calcimycin; Cell Aggregation; Cerebrosides; Galactosylceramides; Globosides; Glycolipids; Glycosphingolipids; Humans; Lactosylceramides; Leukotriene B4; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Psychosine; Sphingolipids; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate; Trihexosylceramides | 1990 |
U937 and THP-1 cells do not release LTB4, LTC4, or LTD4 in response to A23187.
Topics: Calcimycin; Humans; In Vitro Techniques; Interferon-gamma; Leukotriene B4; Monocytes; SRS-A; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Differential inhibition of the T cell activation pathway by dexamethasone and cyclosporine.
Topics: Animals; Antigen-Presenting Cells; Cyclosporins; Dexamethasone; Gene Expression; Interleukin-2; Ionomycin; Leukotriene B4; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
GM-CSF: receptor structure and transmembrane signaling.
Topics: Cell Membrane; Colony-Stimulating Factors; Cross-Linking Reagents; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Platelet Activating Factor; Receptors, Cell Surface; Receptors, Colony-Stimulating Factor; Sepharose; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate 5-Lipoxygenase; Calcimycin; Calcium; Dietary Fats; Ionomycin; Leukotriene B4; Linoleic Acid; Linoleic Acids; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Rats; Rats, Inbred Strains; Receptors, Formyl Peptide; Receptors, Immunologic; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Prostaglandin and leukotriene production by alveolar type II cells in vitro.
Topics: Animals; Calcimycin; Cells, Cultured; Eicosanoids; Kinetics; Leukotriene B4; Leukotrienes; Lung; Macrophages; Male; Prostaglandins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Calcium ionophore potentiates chemotactic peptide and platelet activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils.
Topics: Calcimycin; Drug Synergism; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Radioimmunoassay; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Phorbol ester induces inhibition of arachidonate incorporation into phospholipids in human neutrophils.
Topics: Acyltransferases; Arachidonic Acids; Calcimycin; Coenzyme A Ligases; Enzyme Activation; Humans; Leukotriene B4; Neutrophils; Oleic Acid; Oleic Acids; Phospholipids; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Calcium ionophore but not phorbol ester promotes eicosanoids release by proliferating interleukin-3-dependent bone marrow cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bone Marrow Cells; Calcimycin; Calcium; Cell Division; Clone Cells; Dinoprostone; DNA; Female; Hematopoietic Stem Cells; Interleukin-3; Leukotriene B4; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred CBA; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Dual effect of phorbol myristate acetate on chemoattractant-induced locomotion of human neutrophils.
Topics: Cells, Cultured; Chemotaxis, Leukocyte; Cytosol; Drug Synergism; Enzyme Activation; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1990 |
Platelet-activating factor- and leukotriene B4-induced release of lactoferrin from blood neutrophils of atopic and nonatopic individuals.
Topics: Adult; Cytochalasin B; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; Lactoferrin; Lactones; Leukotriene B4; Male; Neutrophils; Plant Extracts; Platelet Activating Factor; Rhinitis; Tetradecanoylphorbol Acetate | 1990 |
Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase.
Topics: Calcimycin; Chemotactic Factors; Humans; Hydroquinones; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses.
Topics: Animals; Chemotaxis, Leukocyte; Dietary Fats; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Fish Oils; Guinea Pigs; Leukotriene B4; Linoleic Acid; Linoleic Acids; Membrane Lipids; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Olive Oil; Oxygen; Phospholipids; Plant Oils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Chemotaxis, Leukocyte; Colchicine; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Nocodazole; Oligopeptides; Pinocytosis; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Differential regulation of 5-lipoxygenase and cyclo-oxygenase pathways of arachidonate metabolism in rat peritoneal leukocytes.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Female; In Vitro Techniques; Leukocytes; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Alpha-fetoprotein stimulates leukotriene synthesis in P388D1 macrophages.
Topics: alpha-Fetoproteins; Arachidonic Acids; Calcimycin; Interferon-gamma; Leukotriene B4; Lipopolysaccharides; Macrophage Activation; Macrophages; Prostaglandins; Silicon Dioxide; SRS-A; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Release of arachidonic acid metabolites by human monocytes or lymphocytes: effect of treatment with interferon on stimulation by phorbol ester or calcium ionophore.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Humans; Hydroxyeicosatetraenoic Acids; Interferons; Leukotriene B4; Lymphocytes; Monocytes; Prostaglandins; Recombinant Proteins; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1987 |
Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4.
Topics: Calcimycin; Calcium; Cytosol; Humans; Kinetics; Leukotriene B4; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Oxidation-Reduction; Salmonella; Tetradecanoylphorbol Acetate; Zymosan | 1989 |
Correlation between neutrophil superoxide formation, luminol-augmented chemiluminescence and intracellular Ca2+ levels upon stimulation with leukotriene B4, formylpeptide and phorbolester.
Topics: Calcium; Humans; Leukotriene B4; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyridazines; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils.
Topics: Cell Adhesion; Chemotaxis, Leukocyte; Cytoplasmic Granules; Dexamethasone; Endothelium, Vascular; Glucocorticoids; Humans; In Vitro Techniques; Leukotriene B4; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Complement; Tetradecanoylphorbol Acetate | 1989 |
Leukotriene B4 metabolism in neutrophils of patients with chronic granulomatous disease: phorbol myristate acetate decreases endogenous leukotriene B4 via NADPH oxidase-dependent mechanism.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Granulomatous Disease, Chronic; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; SRS-A; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors.
Topics: Animals; Antigens, Differentiation; Antigens, Surface; Bone Marrow Cells; Cell Adhesion; Cell Adhesion Molecules; Chemotactic Factors; Complement C5; Complement C5a; Fluorescent Antibody Technique; Interleukin-1; Interleukin-8; Kinetics; Leukotriene B4; Lipopolysaccharides; Lymphocyte Activation; Macrophage Activation; Macrophage-1 Antigen; Mice; Mice, Inbred BALB C; Neutrophils; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.
Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Membrane Permeability; Cell Movement; Female; Humans; Leukotriene B4; Lung; Male; Microscopy, Electron; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Proteins; Pulmonary Alveoli; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1.
Topics: Animals; Antigens, Differentiation; Antigens, Surface; Ascitic Fluid; Binding, Competitive; Bone Marrow; Cell Adhesion; Cell Movement; Endothelium, Lymphatic; Leukotriene B4; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mice; Mice, Inbred BALB C; Neutrophils; Receptors, Leukocyte-Adhesion; Receptors, Lymphocyte Homing; Tetradecanoylphorbol Acetate | 1989 |
Diacylglycerols and the protein kinase inhibitor H-7 suppress cell polarity and locomotion of Walker 256 carcinosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma 256, Walker; Cell Compartmentation; Cell Movement; Colchicine; Diglycerides; Dose-Response Relationship, Drug; Glycerides; Isoquinolines; Leukotriene B4; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
In vitro effects of leukotriene B4 (LTB4) on canine PMN effector function(s).
Topics: Animals; Chemotaxis, Leukocyte; Dogs; Flow Cytometry; Hydrogen Peroxide; In Vitro Techniques; Leukotriene B4; Light; Membrane Potentials; Neutrophils; Scattering, Radiation; Tetradecanoylphorbol Acetate | 1989 |
Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.
Topics: Humans; Leukotriene B4; Neutrophils; Phorbol Esters; Receptors, Immunologic; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate | 1989 |
Induction of ornithine decarboxylase in the stomach mucosa of swine with NaCl or 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Enzyme Induction; Gastric Mucosa; Leukotriene B4; Male; Ornithine Decarboxylase; Sodium Chloride; Swine; Tetradecanoylphorbol Acetate | 1989 |
Modulation of human neutrophil LTA hydrolase activity by phorbol myristate acetate.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Interactions; Epoxide Hydrolases; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.
Topics: Amines; Enzyme Activation; Humans; Leukotriene B4; Neutrophils; Palmitoylcarnitine; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1987 |
Comparative study of natural and synthetic retinoids as inhibitors of arachidonic acid release and metabolism in rat peritoneal macrophages.
Topics: Animals; Calcimycin; Dinoprostone; Fatty Acids, Unsaturated; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Macrophages; Male; Peritoneal Lavage; Phospholipases A; Prostaglandins E; Rats; Rats, Inbred Strains; Retinoids; Tetradecanoylphorbol Acetate; Thromboxane B2; Zymosan | 1987 |
Intracellular Ca2+ mobilization in immature and more mature U937 induced to differentiate by dimethyl sulfoxide or phorbol myristate acetate.
Topics: Calcium; Cell Differentiation; Cell Line; Cytoplasm; Dimethyl Sulfoxide; Humans; Leukotriene B4; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Tetradecanoylphorbol Acetate | 1988 |
LTB4 production and lysosomal enzyme release by rat alveolar macrophages: effects of phagocytosis, receptor binding, and ionophore stimulation.
Topics: Animals; Calcimycin; Chromatography, High Pressure Liquid; Leukotriene B4; Lysosomes; Macrophages; Masoprocol; Phagocytosis; Pulmonary Alveoli; Rabbits; Rats; Rats, Inbred Strains; Receptors, Complement; Receptors, Fc; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate.
Topics: Calcium; Cholera Toxin; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Pertussis Toxin; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Receptors, Prostaglandin; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils.
Topics: Calcimycin; Cells, Cultured; Endothelium, Vascular; Humans; In Vitro Techniques; Leukotriene B4; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1988 |
Modulation of leukotriene release from human polymorphonuclear leucocytes by PMA and arachidonic acid.
Topics: Arachidonic Acids; Calcimycin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Granulocytes; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; SRS-A; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Zymosan | 1988 |
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Separation; Concanavalin A; Cytoplasm; Digitonin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Protons; Sodium; Tetradecanoylphorbol Acetate | 1988 |
Propionic acid-induced calcium mobilization in human neutrophils.
Topics: Calcium; Cell Line; Cholera Toxin; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid, Acute; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Propionates; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Metabolism of leukotriene B4 by activated human polymorphonuclear granulocytes.
Topics: Calcimycin; Cell-Free System; Diazonium Compounds; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Sulfanilic Acids; Tetradecanoylphorbol Acetate; Thermolysin | 1988 |
Evidence for coordinate, selective regulation of eicosanoid synthesis in platelet-derived growth factor-stimulated 3T3 fibroblasts and in HL-60 cells induced to differentiate into macrophages or neutrophils.
Topics: Animals; Cell Differentiation; Cell Line; Cells, Cultured; Cycloheximide; Dactinomycin; Fibroblasts; Humans; Kinetics; Leukotriene B4; Macrophages; Mice; Microsomes; Neutrophils; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1988 |
Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation.
Topics: Adult; Calcimycin; Cells, Cultured; Chemotactic Factors; Chemotactic Factors, Eosinophil; Enzyme Activation; Eosinophils; Female; Humans; Leukotriene B4; Male; Phosphatidylserines; Platelet Activating Factor; Protein Kinase C; SRS-A; Tetradecanoylphorbol Acetate | 1988 |
Function and stimulus-specific effects of phorbol 12-myristate 13-acetate on human polymorphonuclear neutrophils: autoregulatory role for protein kinase C in signal transduction.
Topics: Exocytosis; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pepstatins; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.
Topics: Acetylglucosaminidase; Animals; Calcimycin; Calcium; Cytoplasmic Granules; Leukotriene B4; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbols; Rabbits; Sodium; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1985 |
Pertussis but not cholera toxin inhibits the stimulated increase in actin association with the cytoskeleton in rabbit neutrophils: role of the "G proteins" in stimulus-response coupling.
Topics: Actins; Animals; Bacterial Toxins; Calcimycin; Calcium; Cholera Toxin; Cytoskeleton; GTP-Binding Proteins; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Protein Binding; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1985 |
Effects of chemotactic factors and other agents on the amounts of actin and a 65,000-mol-wt protein associated with the cytoskeleton of rabbit and human neutrophils.
Topics: Actins; Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cytoskeleton; Glucose; Humans; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Tetradecanoylphorbol Acetate; Urea; Water-Electrolyte Balance | 1985 |
Leukotriene B4 and 12-hydroxyeicosatetraenoic acid stimulate epidermal proliferation in vivo in the guinea pig.
Topics: Animals; Calcimycin; Cell Division; Ear; Epidermal Cells; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Stereoisomerism; Tetradecanoylphorbol Acetate | 1985 |
The inhibition of neutrophil responsiveness caused by phorbol esters is blocked by the protein kinase C inhibitor H7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcium; Cytosol; Exocytosis; Hexosaminidases; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phorbols; Phosphoproteins; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Leukotriene B4 induces formation of inositol phosphates in rat peritoneal polymorphonuclear leukocytes.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; GTP-Binding Proteins; Inositol Phosphates; Kinetics; Leukotriene B4; Male; Neutrophils; Rats; Rats, Inbred F344; Receptors, Immunologic; Receptors, Leukotriene B4; Structure-Activity Relationship; Sugar Phosphates; Tetradecanoylphorbol Acetate; Tritium; Virulence Factors, Bordetella | 1986 |
Protein kinase C regulates leukotriene B4 receptors in human neutrophils.
Topics: Cell Membrane; Diglycerides; Diterpenes; Enzyme Activation; Humans; Leukotriene B4; Neutrophils; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Terpenes; Tetradecanoylphorbol Acetate | 1986 |
A comparative study on the effects of inhibitors of the lipoxygenase pathway on neutrophil function. Inhibitory effects on neutrophil function may not be attributed to inhibition of the lipoxygenase pathway.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Benzoquinones; Calcimycin; Chemotaxis, Leukocyte; Epoprostenol; Humans; Hydroxides; Hydroxyl Radical; Leukotriene B4; Lipoxygenase Inhibitors; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Quinones; Tetradecanoylphorbol Acetate; Umbelliferones | 1986 |
Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiological chemoattractants.
Topics: Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Humans; Interleukin-3; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Membrane; Cell-Free System; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Platelet Activating Factor; Protamine Kinase; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Solubility; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1987 |
The effect of leukotrienes on porcine alveolar macrophage function.
Topics: Acetylglucosaminidase; Animals; Arylsulfatases; Leukotriene B4; Leukotriene E4; Macrophage Activation; Macrophages; Pulmonary Alveoli; SRS-A; Superoxides; Swine; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; Immunoglobulin G; Leukotriene B4; Ligands; Linoleic Acid; Linoleic Acids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Drug; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Membrane; Cell-Free System; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphoric Monoester Hydrolases; Platelet Activating Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway.
Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Enzyme Activation; Humans; Leukotriene B4; Membrane Proteins; Neutrophils; Protein Kinase C; Secretory Rate; Tetradecanoylphorbol Acetate | 1987 |
Signalling for increased cytoskeletal actin in neutrophils.
Topics: Actins; Animals; Calcimycin; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Pertussis Toxin; Platelet Activating Factor; Rabbits; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.
Topics: Ethers; Humans; Hydrogen Peroxide; Ionomycin; Kinetics; Leukotriene B4; Luminescent Measurements; Mathematics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1987 |
Various authentic chemoattractants mediating leukocyte adherence inhibition.
Topics: Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Adhesion; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5; Complement C5a, des-Arginine; Humans; Leukocyte Adherence Inhibition Test; Leukocytes; Leukotriene B4; Liver Neoplasms; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; SRS-A; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1984 |
Association of leukotriene B4 with the cytoskeleton of rabbit neutrophils. Effect of chemotactic factor and phorbol esters.
Topics: Animals; Cytoskeleton; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phorbol Esters; Phorbols; Rabbits; Tetradecanoylphorbol Acetate | 1984 |
Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Humans; In Vitro Techniques; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1981 |
Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation.
Topics: Arachidonic Acids; Calcimycin; Cell Aggregation; Chemotaxis, Leukocyte; Complement C5; Complement C5a; Humans; Kinetics; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1981 |
Leukotriene B4 biosynthesis by alveolar macrophages.
Topics: Animals; Antioxidants; Arachidonic Acids; Calcimycin; Calcium; Catechols; Cells, Cultured; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Leukotriene B4; Macrophages; Masoprocol; Rabbits; Tetradecanoylphorbol Acetate; Zymosan | 1982 |
The myeloperoxidase-dependent metabolism of leukotrienes C4, D4, and E4 to 6-trans-leukotriene B4 diastereoisomers and the subclass-specific S-diastereoisomeric sulfoxides.
Topics: Cell-Free System; Chromatography, High Pressure Liquid; Humans; Leukotriene B4; Leukotriene E4; Neutrophils; Peroxidase; Peroxidases; SRS-A; Stereoisomerism; Sulfoxides; Tetradecanoylphorbol Acetate | 1983 |
Superoxide production of human polymorphonuclear leukocytes stimulated by leukotriene B4.
Topics: Animals; Anions; Calcium; Calcium Channel Blockers; Calmodulin; Cytochalasin B; Dose-Response Relationship, Drug; Gallic Acid; Guinea Pigs; Humans; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.
Topics: Acute-Phase Proteins; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytosol; Humans; Leukotriene B4; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Alkaloids; Arachidonic Acid; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Phospholipases A; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Inhibition of inflammatory responses by epitaondiol and other marine natural products.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Calcimycin; Cytochrome c Group; Ear, External; Edema; Humans; Inflammation; Leukotriene B4; Mice; Neutrophils; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Sesquiterpenes; Steroids; Stimulation, Chemical; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1995 |
Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl phorbol dermal application.
Topics: Acetylglucosaminidase; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capillary Permeability; Dexamethasone; Dinoprostone; Ear Diseases; Edema; Eicosanoids; Indomethacin; Leukotriene B4; Male; Mice; Oligopeptides; Peptide Fragments; Peroxidase; Tetradecanoylphorbol Acetate | 1995 |
Potentiation of the respiratory burst of human neutrophils by cycloheximide: regulation of reactive oxidant production by a protein(s) with rapid turnover?
Topics: Amino Acid Sequence; Calcium; Cycloheximide; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukotriene B4; Luminescent Measurements; Luminol; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Puromycin; Reactive Oxygen Species; Respiratory Burst; Tetradecanoylphorbol Acetate | 1995 |
Activation of human neutrophil LFA-1 (CD11a) by leukotriene B4.
Topics: Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Adhesion; Cell Aggregation; Epitopes; Humans; Leukotriene B4; Lymphocyte Function-Associated Antigen-1; Neutrophils; Tetradecanoylphorbol Acetate | 1993 |
Mechanisms for lipoxin A4 induced neutrophil dependent cytotoxicity for human endothelial cells.
Topics: Azepines; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Triazoles; Umbilical Veins; Virulence Factors, Bordetella | 1995 |
Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.
Topics: Amino Acid Sequence; Calcimycin; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Leukotriene B4; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Receptors, Interleukin-1; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1995 |
Protein kinase C-independent activation of Raf-1 and mitogen-activated protein kinase by leukotriene B4 in guinea pig eosinophils.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Eosinophils; Glyceryl Ethers; Guinea Pigs; In Vitro Techniques; Indoles; Kinetics; Leukotriene B4; Male; Maleimides; Phenylpropionates; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Benzamides; Benzopyrans; Dermatitis, Contact; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indomethacin; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Receptors, Leukotriene B4; Tetradecanoylphorbol Acetate | 1994 |
Effects of ZCR-2060 on allergic airway inflammation and cell activation in guinea-pigs.
Topics: Animals; Benzoates; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte; Eosinophils; Guinea Pigs; Inflammation; Leukotriene B4; Macrophages, Alveolar; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperidines; Platelet Activating Factor; Respiratory Hypersensitivity; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium.
Topics: Antigens, CD; Calcimycin; CD11 Antigens; CD18 Antigens; Cells, Cultured; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipids; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate; Umbilical Veins | 1994 |
Inhibitory effects of sulfonated shale oil fractions on the oxidative burst and Ca++ mobilization in stimulated macrophages.
Topics: Animals; Calcium; Dermatologic Agents; Guinea Pigs; Humans; Hydrogen Peroxide; In Vitro Techniques; Leukotriene B4; Macrophages, Peritoneal; Male; Respiratory Burst; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Determinants of neutrophil HOCl generation: ligand-dependent responses and the role of surface adhesion.
Topics: Cell Adhesion; Cell Membrane; Humans; Hydrogen Peroxide; Hypochlorous Acid; Immunoglobulin G; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Peroxidase; Platelet Activating Factor; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis.
Topics: Animals; Ear, External; Edema; Epidermis; Female; Hyperplasia; Indoles; Inflammation; Leukotriene B4; Mice; Skin Neoplasms; SRS-A; Tetradecanoylphorbol Acetate | 1994 |
Anti-inflammatory action of orally active 5-lipoxygenase inhibitor TMK688.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase Inhibitors; Dermatitis, Contact; Dinoprostone; Dose-Response Relationship, Drug; Female; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Piperidines; Tetradecanoylphorbol Acetate | 1994 |
Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cell Adhesion; Chemotaxis, Leukocyte; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; Hydroxyurea; In Vitro Techniques; Indoles; Interleukin-8; Kinetics; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Lung; Male; Neutrophils; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Separation of agonist-stimulated arachidonate mobilization from subsequent leukotriene B4 synthesis in human neutrophils: different effects of oleoylacetylglycerol and phorbol myristate acetate as priming agents.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Arachidonic Acid; Biological Transport; Calcimycin; Diglycerides; Eicosanoids; Fatty Acids; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Tetradecanoylphorbol Acetate | 1994 |
Effect of indomethacin on increases in leukotriene B4 and pulmonary edema in response to phorbol ester administration in dogs.
Topics: Animals; Bronchoalveolar Lavage Fluid; Dogs; Indomethacin; Leukotriene B4; Male; Pulmonary Edema; Sodium Chloride; Tetradecanoylphorbol Acetate | 1994 |
CD11b/CD18-dependent polymorphonuclear leucocyte interaction with matrix proteins in adhesion and migration.
Topics: Antibodies, Monoclonal; Antigens, CD; CD18 Antigens; Cell Adhesion; Cell Movement; Collagen; Extracellular Matrix Proteins; Fibronectins; Humans; Laminin; Leukotriene B4; Macrophage-1 Antigen; Neutrophils; Peroxidase; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate | 1993 |
Impaired surface expression of PAF receptors on human neutrophils is dependent upon cell activation.
Topics: Calcimycin; Calcium; Cell Aggregation; Cell Membrane; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate | 1994 |
Desensitization by protein kinase C activation differentially uncouples formyl peptide receptors from effector enzymes in HL-60 granulocytes.
Topics: Autoradiography; Calcium; Cell Line; Enzyme Activation; Granulocytes; GTP-Binding Proteins; Leukotriene B4; Membrane Proteins; N-Formylmethionine Leucyl-Phenylalanine; Phospholipase D; Phosphorylation; Protein Kinase C; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Tetradecanoylphorbol Acetate | 1993 |
C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.
Topics: Benzoquinones; Cell Line; Chemotactic Factors; Complement C5a; Humans; In Vitro Techniques; Interleukin-8; Lactams, Macrocyclic; Leukotriene B4; Models, Biological; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Quinones; Receptor, Anaphylatoxin C5a; Receptors, Complement; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor.
Topics: Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, Gel; Chromatography, Ion Exchange; Complement C5a; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunoblotting; Interleukin-8; Isoenzymes; Leukotriene B4; Mitogen-Activated Protein Kinase Kinases; Molecular Weight; Mutagenesis, Site-Directed; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Mapping; Phosphopeptides; Phosphoprotein Phosphatases; Platelet Activating Factor; Point Mutation; Protein Kinases; Protein Phosphatase 2; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1994 |
Altered leukotriene B4 levels by HL-60 cells after monocytic/macrophage differentiation.
Topics: Arachidonic Acids; Cell Differentiation; Cell Division; Cell Line; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipoxygenase; Macrophages; Masoprocol; Monocytes; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1993 |
Evidence that interleukin-1 beta and tumor necrosis factor inhibit gastric fundus motility via the 5-lipoxygenase pathway.
Topics: Animals; Arachidonate 5-Lipoxygenase; Female; Gastric Fundus; Gastrointestinal Motility; In Vitro Techniques; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Male; Muscle Relaxation; Muscle, Smooth; Prostaglandins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells.
Topics: Alkaloids; Amino Acid Sequence; Calcimycin; Cell Line; Glutathione Transferase; Humans; Leukotriene A4; Leukotriene B4; Leukotriene C4; Leukotriene D4; Molecular Sequence Data; Neutrophils; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Regulation of human neutrophil aggregation: comparable latent times, activator sensitivities, and exponential decay in aggregability for FMLP, platelet-activating factor, and leukotriene B4.
Topics: Adult; Cell Aggregation; Dose-Response Relationship, Drug; Humans; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Adhesive interactions of neutrophils and leukotriene synthesis.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Adhesion; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; Neutrophils; Tetradecanoylphorbol Acetate | 1993 |
Effect of ETH615, an inhibitor of leukotriene synthesis and IL-8 gene expression, on murine dermatoses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Dermatitis; Disease Models, Animal; Ear; Edema; Gene Expression; Interleukin-8; Leukotriene B4; Mice; Oxazolone; Peroxidase; Quinolines; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Leukotriene B4 and C4 production in isolated rat gastric mucosal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cell Separation; Colforsin; Diglycerides; Female; Gastric Mucosa; Histamine; In Vitro Techniques; Interleukin-1; Interleukin-2; Kinetics; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Pentagastrin; Phenothiazines; Platelet Activating Factor; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1993 |
Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium.
Topics: Benzophenones; Calcium; Cytosol; GTP-Binding Proteins; Humans; In Vitro Techniques; Leukotriene B4; Monocytes; Pertussis Toxin; Receptors, Immunologic; Receptors, Leukotriene B4; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+.
Topics: Amiloride; Animals; Anti-Infective Agents; Biphenyl Compounds; Calcimycin; Calcium; Carrier Proteins; Cell Survival; Cells, Cultured; Dinoprostone; Hydrogen-Ion Concentration; Hypoxia; Kupffer Cells; Leukotriene B4; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Onium Compounds; Oxidation-Reduction; Oxygen; Prostaglandin D2; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1993 |
Induction of functional lipoxin A4 receptors in HL-60 cells.
Topics: Binding, Competitive; Dactinomycin; Dimethyl Sulfoxide; Enzyme Activation; Humans; Hydroxyeicosatetraenoic Acids; Leukemia, Promyelocytic, Acute; Leukotriene B4; Lipoxins; Neutrophils; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Type C Phospholipases | 1993 |
Human neutrophil adhesion to bovine aortic endothelium. Evidence for endothelial lipoxygenase activity.
Topics: Animals; Arachidonic Acid; Cattle; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Inflammation; Leukotriene B4; Lipoxygenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Characterization of a 64-kd protein phosphorylated during chemotactic activation with IL-8 and fMLP of human polymorphonuclear leukocytes. I. Phosphorylation of a 64-kd protein and other proteins.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Blood Proteins; Chemotactic Factors; Complement C5a; Humans; Interleukin-8; Kinetics; Leukotriene B4; Membrane Glycoproteins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1993 |
Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils.
Topics: Calcium; Cell Adhesion; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Interleukin-1; Leukotriene B4; Lipoxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Inhibition of human mononuclear cell proliferation, interleukin synthesis, mRNA for IL-2, IL-6, and leukotriene B4 synthesis by a lipoxygenase inhibitor.
Topics: Acetamides; Calcimycin; Cell Division; Cells, Cultured; Gene Expression; Humans; Interleukin-2; Interleukin-6; Kinetics; Leukocytes, Mononuclear; Leukotriene B4; Lipoxygenase Inhibitors; Phenyl Ethers; Phytohemagglutinins; Receptors, Interleukin-2; RNA, Messenger; Tetradecanoylphorbol Acetate | 1993 |
Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes.
Topics: Calcimycin; Catalase; Glutathione Transferase; Granulocytes; Humans; Kinetics; Leukotriene A4; Leukotriene B4; Leukotriene C4; Protein Kinase C; Tetradecanoylphorbol Acetate | 1995 |
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cell Survival; Edema; Humans; Hydroquinones; In Vitro Techniques; L-Lactate Dehydrogenase; Leukotriene B4; Mice; Microsomes; Neutrophils; Pancreatic Elastase; Phospholipases A; Phospholipases A2; Porifera; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1995 |
Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils.
Topics: Arachidonic Acids; Calcium; Cell Movement; Cytosol; Humans; Leukotriene B4; Neutrophils; Pertussis Toxin; Stereoisomerism; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1996 |
Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4.
Topics: Animals; Carbazoles; Female; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Indole Alkaloids; Inflammation; Leukotriene B4; Lipoxins; Protein Kinase C; Receptors, Leukotriene B4; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1996 |
Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation.
Topics: Cell Culture Techniques; Dose-Response Relationship, Immunologic; Humans; Interleukin-4; Leukotriene B4; Luminescent Measurements; Monocytes; Receptors, IgE; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1996 |
Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent.
Topics: Administration, Topical; Animals; Anthralin; Anti-Inflammatory Agents; Antifungal Agents; Arachidonic Acid; Carrageenan; Clotrimazole; Cyclooxygenase Inhibitors; Diclofenac; Edema; Granulocytes; Humans; Ketoconazole; Leukotriene B4; Male; Mice; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Calcium; Cell Adhesion; Cilostazol; Complement C3-C5 Convertases; Complement C5a; Cyclooxygenase Inhibitors; Indomethacin; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate; Tetrazoles; Thiazoles; Ticlopidine | 1996 |
Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dermatitis; Dinoprostone; Disease Models, Animal; Docosahexaenoic Acids; Ear, External; Edema; Eicosapentaenoic Acid; Leukotriene B4; Male; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Steroids; Tetradecanoylphorbol Acetate | 1996 |
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Calcimycin; Calcium; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Erythrocytes; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Ionophores; Leukotriene B4; Lipoxygenase; Lung Neoplasms; Neutrophils; Phospholipases A; Phospholipases A2; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils.
Topics: Base Sequence; Binding Sites; Cell Nucleus; Cells, Cultured; Cytokines; Dimerization; DNA-Binding Proteins; HIV; Humans; I-kappa B Proteins; Inflammation; Interferons; Interleukins; Leukotriene B4; Lipopolysaccharides; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; NF-kappa B; NF-KappaB Inhibitor alpha; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1997 |
Human leukaemic (HMC-1) and normal skin mast cells express beta 2-integrins: characterization of beta 2-integrins and ICAM-1 on HMC-1 cells.
Topics: Base Sequence; CD18 Antigens; Cell Aggregation; DNA Primers; Humans; Integrin alphaXbeta2; Intercellular Adhesion Molecule-1; Leukemia, Mast-Cell; Leukotriene B4; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mast Cells; Polymerase Chain Reaction; Skin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1997 |
Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase.
Topics: Antibodies, Monoclonal; Cell Adhesion Molecules; Cell Membrane; Chemotactic Factors; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibronectins; Flow Cytometry; Humans; Leukocyte Elastase; Leukotriene B4; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1997 |
Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capsaicin; Collagenases; Curcumin; Dinoprostone; Hyaluronoglucosaminidase; Leukotriene B4; Leukotriene C4; Lysosomes; Macrophages, Peritoneal; Male; Membrane Lipids; Pancreatic Elastase; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Regulation of leukotriene and platelet-activating factor synthesis in human alveolar macrophages.
Topics: Acetyltransferases; Acyl-Carrier Protein S-Acetyltransferase; Arachidonic Acids; Asthma; Benzenesulfonates; Bronchoalveolar Lavage Fluid; Calcimycin; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; Humans; Ionophores; Leukotriene B4; Leukotrienes; Macrophages, Alveolar; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Urea | 1997 |
Evaluation of the cutaneous anti-inflammatory activity of azaspiranes.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line; Cyclooxygenase 1; Dermatitis, Contact; Dinoprostone; Ear; Edema; Humans; Immunosuppressive Agents; Isoenzymes; Leukotriene B4; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Monocytes; NF-kappa B; Peroxidase; Piperidines; Prostaglandin-Endoperoxide Synthases; Spiro Compounds; Tetradecanoylphorbol Acetate | 1998 |
Arachidonic acid and human bone marrow stromal cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Dinoprostone; Fatty Acids; Humans; Interleukin-6; Leukotriene B4; Lipid Metabolism; Phospholipids; Stromal Cells; Tetradecanoylphorbol Acetate; Tritium; Tumor Necrosis Factor-alpha | 1998 |
The effect of salmeterol on human eosinophils is both stimulus- and response-dependent.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; beta-N-Acetylhexosaminidases; Cell Adhesion; Eosinophil Peroxidase; Eosinophils; Fibronectins; Humans; Interleukin-5; Leukotriene B4; Peroxidases; Platelet Activating Factor; Propanolamines; Salmeterol Xinafoate; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
Topics: Animals; Arachidonic Acid; Blood Platelets; Cell Membrane; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Edema; Enzyme Inhibitors; Furans; Hematocrit; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urea | 1998 |
Arachidonic acid (AA) and tetradecanoylphorbol acetate (TPA) exert systemic effects when applied topically in the mouse.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylglucosaminidase; Administration, Topical; Animals; Arachidonic Acid; Capillary Permeability; Ear; Indomethacin; Leukotriene B4; Male; Mice; Mice, Inbred Strains; Organ Size; Peroxidase; Tetradecanoylphorbol Acetate | 1998 |
Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Chemotactic Factors; Chromatography, High Pressure Liquid; Diarylheptanoids; Ear; Edema; Hydroxyeicosatetraenoic Acids; Ionophores; Ketones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Phenols; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Dependence of neutrophil activation on cell density and adhesion.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Calcium; Cell Adhesion; Cell Count; Cells, Cultured; Drug Synergism; Humans; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Ionophores; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells.
Topics: Antibodies, Monoclonal; CD18 Antigens; Cell Adhesion; Chemokine CCL11; Chemokine CCL4; Chemokine CCL5; Chemokines, CC; Complement C5a; Cytokines; Eosinophils; Epithelial Cells; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Kinetics; Leukotriene B4; Lung; Macrophage Inflammatory Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin.
Topics: Antibodies; CD18 Antigens; Cell Adhesion; Chemotaxis, Leukocyte; Fibrin; Humans; Integrin beta1; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate | 1999 |
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils.
Topics: Androstadienes; Chromones; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Indoles; Leukotriene B4; Maleimides; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin | 1999 |
Production of singlet oxygen by eosinophils activated in vitro by C5a and leukotriene B4.
Topics: Acridines; Animals; Complement C5a; Dihydroxydihydrobenzopyrenes; Eosinophils; Free Radical Scavengers; Guinea Pigs; Hydroxyl Radical; Leukotriene B4; Luminescent Measurements; Molecular Probes; Nitrates; Nitric Oxide; Oxygen; Singlet Oxygen; Superoxides; Tetradecanoylphorbol Acetate | 1999 |
Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis.
Topics: Antimicrobial Cationic Peptides; Apoptosis; Biological Transport; Blood Proteins; Carrier Proteins; Cells, Cultured; Chromatography, Affinity; Endothelium, Vascular; Heparin; Humans; Kinetics; Leukotriene B4; Mitochondria; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Proteoglycans; Recombinant Proteins; Tetradecanoylphorbol Acetate; Umbilical Veins | 1999 |
Chemoattractant receptors activate distinct pathways for chemotaxis and secretion. Role of G-protein usage.
Topics: Animals; Cell Line; Chemotaxis; Exocytosis; GTP-Binding Proteins; Leukotriene B4; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, Formyl Peptide; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; Receptors, Peptide; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1999 |
Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.
Topics: Animals; Arachidonic Acid; Calcium; Cell Aggregation; Dose-Response Relationship, Drug; Eosinophils; Female; Guinea Pigs; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Phospholipases A; Pyrans; Quinacrine; Quinolones; Tetradecanoylphorbol Acetate; Tetrazoles | 1999 |
Lyprinol inhibits LTB4 production by human monocytes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bivalvia; Cells, Cultured; Depression, Chemical; Gene Expression Regulation; Humans; Hydroxyurea; Interleukin-4; Leukotriene B4; Lipids; Lipoxygenase Inhibitors; Monocytes; New Zealand; Receptors, IgE; Recombinant Proteins; Respiratory Burst; Tetradecanoylphorbol Acetate | 2000 |
Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia.
Topics: Adult; Blood Glucose; Calcimycin; Cells, Cultured; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hyperglycemia; Leukotriene B4; Lysosomes; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Zymosan | 2001 |
Activation-induced mobilization of secretory vesicles in bovine neutrophils.
Topics: Alkaline Phosphatase; Animals; Cattle; Inflammation Mediators; Interleukin-8; Leukotriene B4; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Platelet Activating Factor; Secretory Vesicles; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids.
Topics: Anemia, Sickle Cell; Animals; Cell Adhesion; Chromium Radioisotopes; Erythrocytes; Humans; In Vitro Techniques; Leukotriene B4; Male; NADPH Oxidases; Neutrophils; Perfusion; Phospholipids; Platelet Activating Factor; Positive-Pressure Respiration; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tidal Volume | 2002 |
Regulation of human eosinophil NADPH oxidase activity: a central role for PKCdelta.
Topics: Acetophenones; Benzopyrans; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Eosinophils; Humans; Hydrogen-Ion Concentration; Interleukin-5; Isoenzymes; Kinetics; Leukotriene B4; NADPH Oxidases; Patch-Clamp Techniques; Protein Kinase C; Protein Kinase C-delta; Proton Pumps; Superoxides; Tetradecanoylphorbol Acetate; Zinc Compounds | 2001 |
[Modulation of the expression of L-selectin by chemotactic agents and GM-CSF].
Topics: Adolescent; Adult; Female; Flow Cytometry; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Humans; L-Selectin; Leukotriene B4; Lymphocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Tetradecanoylphorbol Acetate | 2002 |
Anti-inflammatory triterpenes from Pistacia terebinthus galls.
Topics: Animals; Anti-Inflammatory Agents; Calcimycin; Cyproheptadine; Dexamethasone; Dose-Response Relationship, Drug; Hindlimb; Inflammation; Ionophores; Leukotriene B4; Magnetic Resonance Spectroscopy; Mice; Neutrophils; Phospholipases A; Phospholipases A2; Pistacia; Plant Extracts; Tetradecanoylphorbol Acetate; Triterpenes | 2002 |
Ex-vivo regulation of endotoxin-induced tissue factor in whole blood by eicosanoids.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Blood; Dose-Response Relationship, Drug; Drug Synergism; Eicosanoids; Gene Expression Regulation; Humans; Leukotriene B4; Lipopolysaccharides; Tetradecanoylphorbol Acetate; Thromboplastin; Tumor Necrosis Factor-alpha | 2003 |
A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum.
Topics: Acetophenones; Analgesics; Animals; Arachidonic Acid; Carrageenan; Dose-Response Relationship, Drug; Ear; Edema; Female; Free Radicals; Glucosides; Helichrysum; Hindlimb; Inflammation; Leukotriene B4; Lipid Peroxidation; Mice; Neutrophils; Peroxidase; Phospholipases A; Plant Extracts; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 2003 |
Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis.
Topics: Animals; Beclomethasone; Cells, Cultured; Chemotaxis, Leukocyte; Dexamethasone; Eosinophils; Glucocorticoids; In Vitro Techniques; Leukocyte Count; Leukotriene B4; Male; Mometasone Furoate; Platelet Activating Factor; Pregnadienediols; Rats; Rats, Sprague-Dawley; Superoxides; Tetradecanoylphorbol Acetate | 2003 |
Mannheimia haemolytica leukotoxin-induced increase in leukotriene B4 production by bovine neutrophils is mediated by a sustained and excessive increase in intracellular calcium concentration.
Topics: Animals; Calcimycin; Calcium; Calcium Signaling; Carcinogens; Cattle; Exotoxins; Ionophores; Leukotriene B4; Mannheimia haemolytica; Neutrophils; Pasteurellosis, Pneumonic; Tetradecanoylphorbol Acetate | 2003 |
Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclooxygenase 2; Dinoprostone; Hydrogen Peroxide; Isoenzymes; Leukotriene B4; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Sitosterols; Squalene; Superoxides; Tetradecanoylphorbol Acetate | 2003 |
In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions.
Topics: Analgesics; Animals; Binding Sites; Calcium; Carrageenan; Cell Movement; Cyclooxygenase 2; Dinoprostone; Dogs; Drug Interactions; Edema; Enzyme Inhibitors; Estrenes; Humans; Interleukin-8; Isoenzymes; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Membrane Proteins; Mice; Neutrophils; Peritoneal Lavage; Phospholipase C beta; Phospholipase D; Prostaglandin-Endoperoxide Synthases; Pyrrolidinones; Rats; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2004 |
Effect of a Korean traditional formulation, Hwaotang, on superoxide generation in human neutrophils, platelet aggregation in human blood, and nitric oxide, prostaglandin E2 production and paw oedema induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Carrageenan; Cell Degranulation; Cyclooxygenase 1; Cyclooxygenase 2; Cytochalasin B; Dinoprostone; Edema; Female; Gastric Mucosa; Gene Expression; Genistein; Hindlimb; Humans; Indomethacin; Isoenzymes; Korea; Leukotriene B4; Lipopolysaccharides; Macrophages, Peritoneal; Medicine, East Asian Traditional; Membrane Proteins; Mice; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pancreatic Elastase; Phosphoproteins; Phosphorylation; Phosphotyrosine; Plant Extracts; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Staurosporine; Stomach; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cucurbitaceae; Cucurbitacins; Dose-Response Relationship, Drug; Edema; Female; Leukocytes; Leukotriene B4; Mice; Pain; Phospholipases A; Phospholipases A2; Phytotherapy; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Triterpenes | 2004 |
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cuba; Dexamethasone; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ear, External; Edema; Eicosanoids; Indomethacin; Interferon-gamma; Leukotriene B4; Lipopolysaccharides; Macrophages; Male; Mangifera; Mice; Oleanolic Acid; Peroxidase; Phospholipases A; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Plants, Medicinal; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Water; Xanthones | 2004 |
Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; HL-60 Cells; Humans; Hydroxylation; Leukotriene B4; Mixed Function Oxygenases; Monocytes; Neutrophils; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 2004 |
Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclooxygenase Inhibitors; Dermatitis; Dose-Response Relationship, Drug; Edema; Female; Inhibitory Concentration 50; Inula; Leukotriene B4; Mice; Neutrophils; Pancreatic Elastase; Phospholipases A; Plant Components, Aerial; Rats; Rats, Wistar; Sesquiterpenes; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biflavonoids; Catechin; Dinoprostone; Drug Synergism; Ear; Edema; Female; Gallic Acid; Inflammation; Interleukin-1; Interleukin-6; Leukotriene B4; Lipoxygenase; Mice; Prostaglandin-Endoperoxide Synthases; Sulindac; Tea; Tetradecanoylphorbol Acetate | 2006 |
Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprostone; Dose-Response Relationship, Drug; Edema; Eicosanoids; Interferon-gamma; Ionophores; Leukotriene B4; Lipopolysaccharides; Macrophages; Male; Mangifera; Mice; Mice, Inbred Strains; Phytotherapy; Plant Bark; Plant Extracts; Tetradecanoylphorbol Acetate | 2006 |
Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Amino Acid Sequence; Animals; Enzyme Activation; Fatty Alcohols; Female; Glycols; In Vitro Techniques; Leukotriene B4; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Pertussis Toxin; Phosphorylation; Protein Kinase C; Receptors, Leukotriene B4; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Triterpenes | 2007 |
Effects of naturally occurring dihydroflavonols from Inula viscosa on inflammation and enzymes involved in the arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Survival; Dinoprostone; Edema; Female; Flavonols; Histamine Release; Humans; In Vitro Techniques; Inflammation; Inula; Leukocyte Elastase; Leukotriene B4; Mice; Neutrophils; Peroxidase; Phospholipases A; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 2007 |
Endothelial PKC delta activation attenuates neutrophil transendothelial migration.
Topics: Antineoplastic Agents; Bryostatins; Carbazoles; Carcinogens; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Humans; Leukotriene B4; Neutrophils; Paxillin; Protein Kinase C-delta; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vinculin | 2008 |
Inhibitory effects of panduratin A on allergy-related mediator production in rat basophilic leukemia mast cells.
Topics: Animals; Arachidonate 5-Lipoxygenase; beta-N-Acetylhexosaminidases; Calcimycin; Calcium; Cell Degranulation; Cell Line, Tumor; Chalcones; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Histamine; Histamine Release; Hypersensitivity, Immediate; Immunoglobulin E; Inflammation Mediators; Interleukin-13; Interleukin-4; JNK Mitogen-Activated Protein Kinases; Leukemia, Basophilic, Acute; Leukotriene B4; Mast Cells; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Prostaglandins E; Proto-Oncogene Proteins c-akt; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zingiberaceae | 2012 |
Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Capillary Permeability; Carrageenan; Coumaric Acids; Cytokines; Dinoprostone; Ear; Edema; Female; Foot; Leukotriene B4; Male; Mice; Monosaccharides; Neutrophils; Opuntia; Peritonitis; Phospholipases A2; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2016 |
Ceruloplasmin-derived peptide is the strongest regulator of oxidative stress and leukotriene synthesis in neutrophils.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; Ceruloplasmin; Humans; Leukotriene B4; Neutrophils; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Phagocytosis; Salmonella typhimurium; Tetradecanoylphorbol Acetate | 2017 |