tetradecanoylphorbol acetate has been researched along with guanosine 5'-o-(3-thiotriphosphate) in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (16.56) | 18.7374 |
| 1990's | 113 (69.33) | 18.2507 |
| 2000's | 22 (13.50) | 29.6817 |
| 2010's | 1 (0.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schäfer, C; Wagner, AC; Williams, JA | 1 |
| Hawkins, PT; Jackson, TR; Stephens, LR | 1 |
| Fain, JN; Lee, HM | 1 |
| Brent, LH; Chou, RH; Gong, QH; Wieland, SJ | 1 |
| Atkinson, TP; Cenciarelli, C; Gusovsky, F; Hohman, RJ; Weissman, AM | 1 |
| Abraham, RT; Leibson, PJ; Schoon, RA; Ting, AT | 1 |
| Mitchison, TJ; Symons, MH | 1 |
| Burgoyne, RD; Turner, MD; Wilde, CJ | 1 |
| Cockcroft, S; Geny, B | 1 |
| Freissmuth, M; Palmer, S; Pyne, NJ | 1 |
| Denning, GM; Welsh, MJ | 1 |
| Fürstenberger, G; Kast, R; Marks, F | 1 |
| Jackson, RC; Koopmann, WR | 1 |
| De Lisle, RC; Kitagawa, M; Williams, JA | 2 |
| Davidson, JS; Millar, RP; van der Merwe, PA; Wakefield, IK | 1 |
| Furuya, W; Grinstein, S | 1 |
| Cantraine, F; Christophe, J; Dehaye, JP; Delporte, C; Poloczek, P; Winand, J | 1 |
| MacNulty, EE; Palmer, S; Plevin, R; Wakelam, MJ | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Berl, T; Mansour, J; Teitelbaum, I | 1 |
| Bowman, EP; Lambeth, JD; Olson, SC | 1 |
| Cockcroft, S; Nielson, CP; Stutchfield, J | 1 |
| Koh, EK; Kuczynski, B; Omann, GM; Smolen, JE; Stoehr, SJ | 1 |
| Anderson, WB; Kiss, Z; Pettit, GR; Rapp, UR | 1 |
| Gardner, SD; Palmer, S; Plevin, R; Wakelam, MJ | 1 |
| Akiba, S; Fujii, T; Sato, T | 2 |
| Drenth, JP; Khalil, RA; Nishimura, J; van Breemen, C | 1 |
| Carroll, AG; Rhoads, AR; Wagner, PD | 1 |
| Katayama, Y; Miyazaki, S; Swann, K | 1 |
| Haslam, RJ; Van der Meulen, J | 1 |
| Churcher, Y; Gomperts, BD; Kramer, KM | 1 |
| Teitelbaum, I | 1 |
| Kajiyama, Y; Murayama, T; Nomura, Y | 1 |
| Cioffi, CL; Fisher, SK | 1 |
| Hartfield, PJ; Robinson, JM | 1 |
| Häring, HU; Kellerer, M; Mushack, J; Obermaier-Kusser, B; Seffer, E | 1 |
| Jungblut, P; Schultz, G; Seifert, R | 1 |
| Huang, CL; Ives, HE | 1 |
| Igusa, Y; Miyazaki, S; Swann, K | 1 |
| Gomperts, BD; Howell, TW; Kramer, IM | 1 |
| Burgoyne, RD; Morgan, A; O'Sullivan, AJ | 1 |
| Baldassare, JJ; Fisher, GJ; Henderson, PA | 1 |
| Cockcroft, S; Geny, B; Stutchfield, J | 1 |
| Jaggi, C; Li, G; Regazzi, R; Ullrich, S; Wollheim, CB | 1 |
| Aunis, D; Bader, MF; Sontag, JM; Thiersé, D | 1 |
| Bennett, TE; Driver, AG; Kukoly, CA | 1 |
| Cockcroft, S; Stutchfield, J | 1 |
| Harnett, MM; Klaus, GG | 1 |
| Imaizumi, T; Mizushima, A; Osugi, T; Uchida, S; Yoshida, H | 1 |
| Devanney, JF; Huang, CK; Kanaho, Y | 1 |
| Biden, TJ; Vallar, L; Wollheim, CB | 1 |
| Smith, CD; Snyderman, R; Uhing, RJ | 1 |
| Mueller, GC; Tettenborn, CS | 1 |
| Kakkar, VV; Krishnamurthi, S | 1 |
| Penner, R | 1 |
| Bauer, S; Jakobs, KH | 1 |
| Endo, Y; Kopf, GS; Lee, MA | 1 |
| Ahnert-Hilger, G; Bräutigam, M; Gratzl, M | 1 |
| Llano, I; Marty, A | 1 |
| Brown, JH; Orellana, S; Solski, PA | 1 |
| Baker, PF; Knight, DE | 1 |
| Johnson, GL; Kelleher, DJ; Pessin, JE; Ruoho, AE | 1 |
| Golard, A; Role, LW; Siegelbaum, SA | 1 |
| Dehaye, JP; Grosfils, K; Métioui, M | 1 |
| Bourgoin, S; Houle, MG; Kahn, RA; Naccache, PH | 1 |
| Guild, SB; MacEwan, DJ; McFerran, BW | 1 |
| Akaike, N; Uneyama, C; Uneyama, H | 1 |
| Ebina, Y; Hayashi, H; Kamohara, S; Kanai, F; Nishioka, Y; Todaka, M | 1 |
| De Matteis, MA; Di Tullio, G; Kahn, RA; Luini, A; Santini, G | 1 |
| Di Marzo, V; Piomelli, D; Schwartz, JC; Sokoloff, P; Vial, D | 1 |
| Berridge, MJ; Petersen, CC | 1 |
| Abramson, SB; Feoktistov, A; Philips, MR; Pillinger, MH | 1 |
| Akisue, T; Inoue, H; Nakamura, S; Shimooku, K | 1 |
| Ruotsalainen, M; Savolainen, KM | 1 |
| De Lisle, RC; Howell, GW | 1 |
| Kwiatkowska, K; Muallem, S; Xu, X; Yin, HL | 1 |
| Koss, M; Massry, SG; Smogorzewski, M; Tanaka, H | 1 |
| Briscoe, CP; Cross, M; Martin, A; Wakelam, MJ | 1 |
| Cockcroft, S; Cronin, P; Whatmore, J | 1 |
| Karpinski, E; Liu, QY; Pang, PK | 1 |
| Khilnani, H; Klin, M; Massry, SG; Michnowska, M; Smogorzewski, M | 1 |
| Davidson, JS; Millar, RP; Wakefield, IK | 1 |
| Asaoka, Y; Nishizuka, Y; Tsujishita, Y | 1 |
| Ali, H; Didsbury, JR; Menard, L; Richardson, RM; Snyderman, R; Tomhave, ED | 1 |
| Hsieh, JT; Ong, R; Yang, CM; Yo, YL | 1 |
| Araki, K; Kato, M; Matsuura, Y; Nishiyama, T; Sasaki, T; Takai, Y; Takaishi, K; Yaku, H | 1 |
| Polgar, P; Ricupero, D; Taylor, L | 1 |
| Fujii, T; Hashizume, T; Sato, T; Taniguchi, M | 1 |
| Agius, L; Peak, M | 1 |
| Banno, Y; Nozawa, Y; Okano, Y | 1 |
| Alexandropoulos, K; Foster, DA; Jiang, H; Song, J | 1 |
| Coorssen, JR; Haslam, RJ | 2 |
| Kowluru, A; Metz, SA; Rabaglia, ME; Stock, JB | 1 |
| Jungermann, K; Miura, H; Neuschäfer-Rube, F; Püschel, GP | 1 |
| Jaconi, ME; Krause, KH; Lew, DP; Monod, A | 1 |
| Hawkins, PT; Jackson, TR; Stephens, L | 1 |
| Mattera, R; McConnell, BK; Wilkins, PL; Xing, M | 1 |
| Bosenberg, MW; Massagué, J; Pandiella, A | 1 |
| Jones, CT; Khouja, A | 1 |
| de Bont, DB; Hilarius, PM; Kessels, GC; Leusen, JH; Liskamp, RM; Verhoeven, AJ | 1 |
| Olianas, MC; Onali, P | 1 |
| Minakami, S; Mitsuyama, T; Takeshige, K | 1 |
| Jones, PM; Mann, FM; Persaud, SJ; Wheeler-Jones, CP | 1 |
| Bienek, C; Jakobs, KH; Keller, J; Rümenapp, U; Schmidt, M; von Eichel-Streiber, C | 1 |
| Butcher, EC; Campbell, JJ; Laudanna, C | 1 |
| Edwards, SW; Galvani, DW; Lowe, GM; Slupsky, JR | 1 |
| Ebina, Y; Hayashi, H; Imanaka, T; Kamohara, S; Kanai, F; Kishi, K; Mitani, Y; Morii, N; Narumiya, S; Shichiri, M; Tamaoka, K; Todaka, M | 1 |
| Banno, Y; Kato, N; Lyerly, DM; Miyata, H; Nakashima, S; Nozawa, Y; Ojio, K; Watanabe, K | 1 |
| Bielawska, A; Obeid, LM; Venable, ME | 1 |
| Gong, MC; Jensen, PE; Somlyo, AP; Somlyo, AV | 1 |
| de Takats, PG; Kerr, DJ; Martin, A; Reynolds, JL; Wakelam, MJ | 1 |
| Banno, Y; Kato, N; Lyerly, DM; Nakashima, S; Nozawa, Y; Ohguchi, K; Watanabe, K | 1 |
| Ali, H; Haribabu, B; Richardson, RM; Snyderman, R | 1 |
| Akao, M; Bremerich, DH; Hirasaki, A; Jones, KA; Warner, DO; Wong, GY | 1 |
| Aktories, K; Koch, G; Wex, CB | 1 |
| Dubois, T; Geny, B; Lukowski, S; Mira, JP; Oudinet, JP; Russo-Marie, F | 1 |
| Dubyak, GR; Kertesy, SB | 1 |
| Guild, SB; McFerran, BW | 1 |
| Chen, Y; Penington, NJ | 1 |
| Alonso, A; Bayon, Y; Garcia-Sancho, J; Hernandez, M; Leslie, C; Nieto, ML; Nuñez, L; Sanchez Crespo, M | 1 |
| Capito, K; Hedeskov, CJ; Kardasz, AM; Thams, P | 1 |
| Banno, Y; Dohjima, T; Kato, N; Kato, Y; Nozawa, Y; Tatematsu, N; Watanabe, K | 1 |
| García-Sáinz, JA; Medina, LC; Vázquez-Prado, J | 1 |
| Grannass, A; Jakobs, KH; Rümenapp, U; Schmidt, M; Tapp, E; Wahn, F | 1 |
| Haslam, RJ; Sloan, DC | 1 |
| Chuprun, JK; Rapoport, RM | 1 |
| Exton, JH; Guillemain, I | 1 |
| Barritt, GJ; Brereton, H; Lan, L | 1 |
| Choi, MU; Lee, SY; Yeo, EJ | 1 |
| Coorssen, JR; Lindau, M; Scepek, S | 1 |
| Ashcroft, SJ; Johnson, G; Tian, YA | 1 |
| Gomperts, BD; O'Sullivan, AJ; Pinxteren, JA; Tatham, PE | 1 |
| Nie, Y; Romero, G; Shome, K | 1 |
| Cunningham, ML; Filtz, TM; Harden, TK | 1 |
| Gibbs, TC; Meier, KE | 1 |
| Banno, Y; Dohi, S; Nakashima, S; Nozawa, Y; Ohguchi, K; Ono, Y; Tan, Z | 1 |
| García-Sáinz, JA; Gottfried-Blackmore, A; Romero-Avila, MT; Vázquez-Prado, J | 1 |
| Bourgoin, S; Houle, MG; Naccache, PH | 1 |
| Kwak, JY; Uhlinger, DJ | 1 |
| García-Sáinz, JA; González-Espinosa, C; Medina, LC; Romero-Avila, MT; Vázquez-Prado, J | 1 |
| Barrett, CF; Rittenhouse, AR | 1 |
| Deli, E; Kiss, Z | 1 |
| Levy, R; Pessach, I | 1 |
| Fujimura, A; Harada, K; Kawaguchi, A; Ohmori, M; Sugimoto, K; Tsuruoka, S | 1 |
| Byers, DM; Cook, HW; Morash, SC | 1 |
| Cunningham, ML; Harden, TK; Hepler, JR; Hollinger, S; Waldo, GL | 1 |
| Leto, TL; Levy, R; Malech, HL; Pessach, I | 1 |
| García, DE; García-Ferreiro, RE; Hernández-Ochoa, EO | 1 |
| Bosch, RR; De Pont, JJ; Harris, AB; van Emst-de Vries, SE; Willems, PH | 1 |
| Albert, PR; Kushwaha, N; Penington, NJ; Wu, X | 1 |
| Bourgoin, SG; Brindley, DN; Gagnon, S; Harbour, D; Houle, MG; Morris, AJ; Singh, IN | 1 |
| Burgoyne, RD; Graham, ME; McMahon, HT; O'Callaghan, DW | 1 |
| Bao, X; Haslam, RJ; Sloan, DC; Wang, P | 1 |
| Barton, JA; Iyer, SS; Kusner, DJ; Rubenstein, PA; Wang, X; Wen, KK | 1 |
| Akerman, KE; Holmqvist, T; Kukkonen, JP; Näsman, J | 1 |
| Brown, GE; Ha, VL; Liu, H; Stewart, MQ; Yaffe, MB | 1 |
| Choi, S; Chung, MH; Kim, HJ; Ryu, HO; Ye, SK; Yoon, BH; Yoon, SH | 1 |
| Bourgoin, S; Riebeling, C; Shields, D | 1 |
| Fei, XW; He, YL; Mei, YA; Yang, G; Zhang, M | 1 |
| Balletta, A; Bigalke, H; Gerhard, R; Lorenz, D; Rummel, A; Wegner, F | 1 |
1 review(s) available for tetradecanoylphorbol acetate and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Evidence that activation of phospholipase D can mediate secretion from permeabilized platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Blood Proteins; Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Egtazic Acid; Enzyme Activation; Ethanol; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Phospholipase D; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
162 other study(ies) available for tetradecanoylphorbol acetate and guanosine 5'-o-(3-thiotriphosphate)
| Article | Year |
|---|---|
Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.
Topics: Amylases; Animals; Bacterial Proteins; Calcium; Carcinogens; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ethers, Cyclic; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Rats; Rats, Sprague-Dawley; Streptolysins; Tetradecanoylphorbol Acetate | 1992 |
Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells.
Topics: 1-Phosphatidylinositol 4-Kinase; 3T3 Cells; Alprostadil; Animals; Bombesin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Growth Substances; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Hormones; Inositol Phosphates; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Phosphates; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphotransferases; Platelet-Derived Growth Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Vasopressins | 1992 |
Magnesium-dependent inhibition of agonist-stimulated phosphoinositide breakdown in rat cortical slices by excitatory amino acids.
Topics: Amino Acids; Animals; Calcium; Calcium Channel Blockers; Carbachol; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Magnesium; Male; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
A lineage-specific Ca(2+)-activated K+ conductance in HL-60 cells.
Topics: Bucladesine; Calcium; Cell Differentiation; Charybdotoxin; Granulocytes; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Leukemia, Promyelocytic, Acute; Macrophages; Membrane Potentials; Potassium Channels; Scorpion Venoms; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor zeta chain.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanylyl Imidodiphosphate; Mice; Phosphorylation; Receptors, Antigen, T-Cell, gamma-delta; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured; Tyrosine | 1992 |
Interaction between protein kinase C-dependent and G protein-dependent pathways in the regulation of natural killer cell granule exocytosis.
Topics: Alkaloids; Antigens, CD; Cell Line; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Killer Cells, Natural; Kinetics; Protein Kinase C; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts.
Topics: Amino Acid Sequence; Animals; Cell Adhesion; Cell Line; Cytoskeleton; Dimethyl Sulfoxide; Fibroblasts; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Molecular Sequence Data; Oligopeptides; Pseudopodia; Tetradecanoylphorbol Acetate; Xenopus | 1992 |
Exocytosis from permeabilized lactating mouse mammary epithelial cells. Stimulation by Ca2+ and phorbol ester, but inhibition of regulated exocytosis by guanosine 5'-[gamma-thio]triphosphate.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Epithelium; Exocytosis; Female; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Lactation; Mammary Glands, Animal; Mice; Mice, Inbred Strains; Proteins; Tetradecanoylphorbol Acetate | 1992 |
Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.
Topics: Adenosine Triphosphate; Alkaloids; Bacterial Proteins; Cell Line; Cell Membrane Permeability; Drug Synergism; Enzyme Activation; Glycerophospholipids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Neomycin; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Staurosporine; Streptolysins; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Phosphorylation of the spliced variant forms of the recombinant stimulatory guanine-nucleotide-binding regulatory protein (Gs alpha) by protein kinase C.
Topics: Alkaloids; Animals; Autoradiography; Blotting, Western; Brain; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Phosphorylation; Protein Kinase C; Rats; Recombinant Proteins; RNA Splicing; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Polarized distribution of bradykinin receptors on airway epithelial cells and independent coupling to second messenger pathways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Membrane; Cells, Cultured; Dogs; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Kinetics; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Tetradecanoylphorbol Acetate; Trachea | 1991 |
Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism.
Topics: Animals; Arachidonic Acid; Bradykinin; Carbon Radioisotopes; Cell Line; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Keratinocytes; Kinetics; Lysophosphatidylcholines; Mice; NAD; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Calcium- and guanine-nucleotide-dependent exocytosis in permeabilized rat mast cells. Modulation by protein kinase C.
Topics: Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Digitonin; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine Release; Kinetics; L-Lactate Dehydrogenase; Male; Mast Cells; Protein Kinase C; Rats; Rats, Inbred Strains; Signal Transduction; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Amylase release from streptolysin O-permeabilized pancreatic acini.
Topics: Alkaloids; Amylases; Animals; Bacterial Proteins; Calcium; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Male; Mice; Pancreas; Protein Kinase C; Staurosporine; Streptolysins; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Interactions of intracellular mediators of amylase secretion in permeabilized pancreatic acini.
Topics: Adenosine Triphosphate; Amylases; Animals; Bacterial Proteins; Calcium; Cell Membrane Permeability; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Pancreas; Secretory Rate; Streptolysins; Temperature; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Cyclic AMP; Egtazic Acid; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kinetics; Luteinizing Hormone; Pituitary Gland, Anterior; Second Messenger Systems; Sheep; Tetradecanoylphorbol Acetate | 1991 |
Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils.
Topics: Adenine Nucleotides; Alkaloids; Aluminum; Aluminum Compounds; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine; Virulence Factors, Bordetella | 1991 |
The metabolic effects of guanyl nucleotides on rat pancreatic acini permeabilized with streptolysin O suggest a widespread use of G proteins.
Topics: Amylases; Animals; Arachidonic Acid; Bacterial Proteins; Calcium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Inositol Phosphates; Male; Pancreas; Permeability; Rats; Rats, Inbred Strains; Streptolysins; Tetradecanoylphorbol Acetate | 1991 |
Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Endothelins; Fibroblasts; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Lysophospholipids; Phosphatidylinositols; Phosphorylation; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1991 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
ANP stimulates phospholipase C in cultured RIMCT cells: roles of protein kinases and G protein.
Topics: Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Inositol Phosphates; Kidney Tubules, Collecting; Pertussis Toxin; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases; Virulence Factors, Bordetella | 1991 |
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
Topics: Adenosine Triphosphate; Adult; Alkaloids; Calcium; Cell Membrane; Cell-Free System; Cytosol; Enzyme Activation; Ethanol; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrogen-Ion Concentration; Kinetics; Magnesium; Neutrophils; Phosphatidic Acids; Phospholipase D; Proteins; Staurosporine; Substrate Specificity; Tetradecanoylphorbol Acetate | 1991 |
Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction.
Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; Neomycin; Phospholipases A; Phospholipases A2; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Dual effects of guanosine 5'-[gamma-thio]triphosphate on secretion by electroporated human neutrophils.
Topics: Actins; Adult; Calcium; Cholera Toxin; Cytochalasin D; Cytoplasmic Granules; Electric Stimulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Magnesium; Neutrophils; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Bryostatins; Cell Line; Cell Transformation, Neoplastic; Genes, ras; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Kinetics; Lactones; Macrolides; Mice; Mice, Inbred Strains; Oncogene Proteins v-raf; Oncogenes; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Protein-Tyrosine Kinases; Retroviridae Proteins, Oncogenic; Rubidium; Tetradecanoylphorbol Acetate | 1991 |
Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein.
Topics: Animals; Bombesin; Cell Membrane Permeability; Cells, Cultured; Drug Synergism; Fibroblasts; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Mice; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets.
Topics: Alkaloids; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cell Membrane Permeability; Chlorides; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pertussis Toxin; Protein Kinase C; Rabbits; Saponins; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Evidence for increased myofilament Ca2+ sensitivity in norepinephrine-activated vascular smooth muscle.
Topics: Actin Cytoskeleton; Animals; Calcium; Cytoskeleton; Egtazic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Rats, Inbred WKY; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1990 |
Hydrolysis-resistant GTP analogs stimulate catecholamine release from digitonin-permeabilized PC12 cells.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Calcium; Cell Membrane Permeability; Digitonin; Ethylmaleimide; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Kinetics; Norepinephrine; Pheochromocytoma; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 1990 |
Synergistic activation by serotonin and GTP analogue and inhibition by phorbol ester of cyclic Ca2+ rises in hamster eggs.
Topics: Aequorin; Animals; Calcium; Cricetinae; Drug Synergism; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Potentials; Mesocricetus; Ovum; Protein Kinase C; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5'-[gamma-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary
Topics: Animals; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Glycerophospholipids; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Phorbol Esters; Phosphatidic Acids; Phospholipase D; Phospholipids; Protein Kinase C; Rabbits; Stimulation, Chemical; Substrate Specificity; Tetradecanoylphorbol Acetate; Thrombin; Tritium | 1990 |
Evidence for protein dephosphorylation as a permissive step in GTP-gamma-S-induced exocytosis from permeabilized mast cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Ethers, Cyclic; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Male; Mast Cells; Okadaic Acid; Phosphorylation; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells.
Topics: Adenosine Diphosphate Ribose; Aluminum; Aluminum Compounds; Animals; Calcium; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Kinetics; Pertussis Toxin; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Immune Sera; Kinetics; Norepinephrine; Pertussis Toxin; Phospholipases; Phospholipases A; Phospholipases A2; Rabbits; Receptors, Histamine H1; Serotonin; Tetradecanoylphorbol Acetate; Thionucleotides; Thrombin; Virulence Factors, Bordetella | 1990 |
Reduction of muscarinic receptor density and of guanine nucleotide-stimulated phosphoinositide hydrolysis in human SH-SY5Y neuroblastoma cells following long-term treatment with 12-O-tetradecanoylphorbol 13-acetate or mezerein.
Topics: Calcium; Culture Media; Cytoplasm; Diterpenes; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Inositol Phosphates; Neuroblastoma; Osmolar Concentration; Phosphatidylinositols; Protein Kinase C; Receptors, Muscarinic; Sodium Fluoride; Terpenes; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1990 |
Mg.ATP primes superoxide-generating responses in electropermeabilized neutrophils.
Topics: Adenosine Triphosphate; Animals; Cell Membrane Permeability; Electricity; Enzyme Induction; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
TPA inhibits insulin stimulated PIP hydrolysis in fat cell membranes: evidence for modulation of insulin dependent phospholipase C by proteinkinase C.
Topics: Adipose Tissue; Animals; Calcium; Cell Membrane; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Insulin; Insulin Antagonists; Kinetics; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1990 |
Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bucladesine; Calcimycin; Cell Differentiation; Cell Line; Cytosol; Dimethyl Sulfoxide; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hexachlorocyclohexane; Humans; Kinetics; Leukemia, Promyelocytic, Acute; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Superoxides; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. Signaling mechanisms distinguished by sensitivity to pertussis toxin and p
Topics: Animals; Cell Membrane Permeability; Drug Synergism; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Muscle, Smooth, Vascular; Pertussis Toxin; Platelet-Derived Growth Factor; Rats; Signal Transduction; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides; Thrombin; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Differential effects of phorbol 12-myristate 13-acetate on GTP gamma S-induced diacylglycerol formation and arachidonic acid liberation in saponin-permeabilized rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Lipids; Permeability; Phospholipases A; Phospholipases A2; Rabbits; Saponins; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1989 |
Evidence for an inhibitory effect of protein kinase C on G-protein-mediated repetitive calcium transients in hamster eggs.
Topics: Animals; Calcium; Cricetinae; Diglycerides; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Male; Membrane Potentials; Mesocricetus; Ovum; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Protein phosphorylation and the dependence on Ca2+ and GTP-gamma-S for exocytosis from permeabilised mast cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane Permeability; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Mast Cells; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
The control of cytoskeletal actin and exocytosis in intact and permeabilized adrenal chromaffin cells: role of calcium and protein kinase C.
Topics: Actins; Adrenal Medulla; Animals; Barium; Calcium; Cattle; Cell Membrane Permeability; Cytoskeleton; Digitonin; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Neomycin; Nicotine; Potassium; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate).
Topics: Blood Platelets; Cell Membrane; Drug Synergism; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; In Vitro Techniques; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Thionucleotides; Thrombin; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Phorbol ester inhibits polyphosphoinositide phosphodiesterase activity stimulated by either Ca2+, fluoride or GTP analogue in HL60 membranes and in permeabilized HL60 cells.
Topics: Calcium; Cell Membrane; Cell Membrane Permeability; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 1989 |
Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Cell Membrane Permeability; Diglycerides; Enzyme Activation; Glycerides; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Insulin; Insulin Secretion; Kinetics; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
A reassessment of guanine nucleotide effects on catecholamine secretion from permeabilized adrenal chromaffin cells.
Topics: Adenosine Triphosphate; Adrenal Medulla; Animals; Bacterial Toxins; Calcium; Cattle; Cell Membrane Permeability; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hemolysin Proteins; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Neurotoxins; Norepinephrine; Sphingosine; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Expression of histamine H1 receptors on cultured histiocytic lymphoma cells.
Topics: Cycloheximide; Dactinomycin; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Lymphoma, Large B-Cell, Diffuse; Pyrilamine; Receptors, Histamine H1; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 1989 |
Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O.
Topics: Adenosine Triphosphate; Bacterial Proteins; Calcium; Cell Line; Cell Membrane Permeability; Enzyme Activation; Exocytosis; Glucuronidase; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol Phosphates; L-Lactate Dehydrogenase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Streptolysins; Tetradecanoylphorbol Acetate; Thionucleotides | 1988 |
Protein kinase C activators inhibit the antigen receptor-coupled polyphosphoinositide phosphodiesterase in murine B lymphocytes.
Topics: Animals; B-Lymphocytes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol Phosphates; Kinetics; Mice; Mice, Inbred CBA; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Protein Kinase C; Receptors, Antigen, B-Cell; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides | 1988 |
Phorbol ester inhibits bradykinin-stimulated inositol trisphosphate formation and calcium mobilization in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Bradykinin; Calcium; Cell Line; Diglycerides; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Neuroblastoma; Protein Kinase C; Receptors, Bradykinin; Receptors, Neurotransmitter; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1987 |
Regulation of membrane associated protein kinase C activity by guanine nucleotide in rabbit peritoneal neutrophils.
Topics: Animals; Calcium; Cell Membrane; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histones; Membrane Proteins; Neutrophils; Peritoneal Cavity; Phosphatidylinositols; Phosphoproteins; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
Topics: Animals; Calcium; Cell Line; Cell Membrane Permeability; Cholera Toxin; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Insulin; Insulin Secretion; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1987 |
Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
Topics: Calcium; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phorbol Esters; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases; Virulence Factors, Bordetella | 1987 |
12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates.
Topics: Cell Fractionation; Cell Line; Enzyme Activation; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Phosphatidic Acids; Phosphatidylglycerols; Phospholipase D; Phospholipases; Tetradecanoylphorbol Acetate; Thionucleotides; Ultracentrifugation | 1988 |
Phorbol ester treatment inhibits thrombin but not stable GTP analogue-induced platelet granule secretion despite inhibition of phosphatidate formation with both agonists.
Topics: Blood Platelets; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Male; Phosphatidic Acids; Platelet Aggregation; Serotonin; Tetradecanoylphorbol Acetate; Thionucleotides; Thrombin; Time Factors | 1988 |
Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.
Topics: Animals; Benzofurans; Calcium; Fura-2; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Mast Cells; Models, Biological; Neomycin; p-Methoxy-N-methylphenethylamine; Peritoneum; Pertussis Toxin; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1988 |
Phorbol ester treatment impairs hormone- but not stable GTP analog-induced inhibition of adenylate cyclase.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclase Inhibitors; Blood Platelets; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Hydrolysis; Lymphoma; Phorbols; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thionucleotides | 1986 |
Characterization of an islet-activating protein-sensitive site in mouse sperm that is involved in the zona pellucida-induced acrosome reaction.
Topics: Acrosome; Aminoacridines; Animals; Calcimycin; Calcium; Chlortetracycline; Female; Fluorescent Dyes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Mice; Microscopy, Electron; Ovum; Pertussis Toxin; Quinuclidinyl Benzilate; Sperm Capacitation; Spermatozoa; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella; Zona Pellucida | 1988 |
Ca2+-stimulated catecholamine release from alpha-toxin-permeabilized PC12 cells: biochemical evidence for exocytosis and its modulation by protein kinase C and G proteins.
Topics: Adrenal Gland Neoplasms; Animals; Bacterial Toxins; Calcium; Cell Line; Cell Membrane Permeability; Dopamine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hemolysin Proteins; Kinetics; Neurotoxins; Nigericin; Norepinephrine; Pheochromocytoma; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Protein kinase C activators inhibit the inositol trisphosphate-mediated muscarinic current responses in rat lacrimal cells.
Topics: Acetylcholine; Animals; Calcium; Electrophysiology; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lacrimal Apparatus; Protein Kinase C; Rats; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.
Topics: Bradykinin; Carbachol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Histamine; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Membranes; Phorbol Esters; Protein Kinase C; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thionucleotides | 1987 |
Guanine nucleotides and Ca-dependent exocytosis. Studies on two adrenal cell preparations.
Topics: Adrenal Glands; Animals; Calcium; Cattle; Chickens; Diglycerides; Exocytosis; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Tetradecanoylphorbol Acetate; Thionucleotides | 1985 |
Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.
Topics: Adenylyl Cyclases; Animals; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Phorbols; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Thionucleotides; Time Factors; Turkeys | 1984 |
Protein kinase C blocks somatostatin-induced modulation of calcium current in chick sympathetic neurons.
Topics: Animals; Calcium Channels; Chick Embryo; Electric Stimulation; Enzyme Activation; Ganglia, Sympathetic; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Lactams; Naphthalenes; Neurons; Polycyclic Compounds; Protein Kinase C; Receptors, Somatostatin; Somatostatin; Sympathetic Nervous System; Tetradecanoylphorbol Acetate | 1993 |
Mepacrine inhibits amylase secretion mediated by a guanylnucleotide binding protein.
Topics: Aluminum; Amylases; Animals; Bombesin; Enzyme Activation; Fluorine; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pancreas; Permeability; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Secretory Rate; Tetradecanoylphorbol Acetate | 1994 |
ADP-ribosylation factor translocation correlates with potentiation of GTP gamma S-stimulated phospholipase D activity in membrane fractions of HL-60 cells.
Topics: ADP-Ribosylation Factors; Carcinogens; Carrier Proteins; Cell Membrane; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Phospholipase D; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1995 |
Involvement of multiple protein kinase C isozymes in the ACTH secretory pathway of AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Calcium; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Irritants; Isoenzymes; Male; Mice; Phenanthridines; Phorbol Esters; Pituitary Gland, Anterior; Pituitary Neoplasms; Protein Kinase C; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Alkaloids; Animals; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Colforsin; Cyclic AMP; Cytoplasm; Egtazic Acid; Female; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Male; Megakaryocytes; Models, Biological; Oscillometry; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1993 |
Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain.
Topics: 3T3 Cells; Adipose Tissue; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Cell Membrane; CHO Cells; Cricetinae; Deoxyglucose; DNA; Epitopes; Gene Expression; Genes, myc; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Insulin; Kinetics; Mice; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Insertional; Protein Processing, Post-Translational; Sodium Fluoride; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex.
Topics: ADP-Ribosylation Factors; Aluminum; Animals; Brefeldin A; Cell Membrane Permeability; Coatomer Protein; Cyclopentanes; Enzyme Activation; Fluorine; Glycosaminoglycans; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Microtubule-Associated Proteins; Naphthalenes; Phorbol Esters; Polycyclic Compounds; Protein Binding; Protein Kinase C; Rats; Receptors, IgE; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
G-protein regulation of capacitative calcium entry may be mediated by protein kinases A and C in Xenopus oocytes.
Topics: Adenylyl Cyclases; Aluminum Compounds; Animals; Calcium; Chloride Channels; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Enzyme Activation; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Oocytes; Protein Kinase C; Tetradecanoylphorbol Acetate; Type C Phospholipases; Xenopus laevis | 1995 |
Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity.
Topics: Cell Fractionation; Cell Membrane; Cell-Free System; Cytosol; GTP Phosphohydrolases; GTP-Binding Proteins; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphoproteins; rac GTP-Binding Proteins; Tetradecanoylphorbol Acetate | 1995 |
Potential role of protein phosphorylation in GTP-gamma-S-dependent activation of phospholipase D.
Topics: Adenosine Triphosphate; Alkaloids; Cell Line; Enzyme Activation; Genistein; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoflavones; Phospholipase D; Phosphorylation; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
The role of G-proteins in the activation of human leukocytes by particulate stimuli to produce reactive oxygen metabolites.
Topics: Adult; Asbestos, Serpentine; Calcium; Cholera Toxin; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Pertussis Toxin; Quartz; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bacterial Proteins; Calcium; Cell Membrane Permeability; Cholera Toxin; Cyclic AMP; Exocytosis; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intercellular Signaling Peptides and Proteins; Isoquinolines; Macromolecular Substances; Mice; Pancreas; Peptides; Pertussis Toxin; Protein Kinase Inhibitors; Streptolysins; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wasp Venoms | 1995 |
Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.
Topics: Actins; Animals; Calcium; Carbachol; Cell Membrane Permeability; Cytoskeleton; Exocytosis; Gelsolin; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Pancreas; Polymers; Rats; Sincalide; Streptolysins; Tetradecanoylphorbol Acetate; Thymosin | 1995 |
Pathways involved in PTH-induced rise in cytosolic Ca2+ concentration of rat renal proximal tubule.
Topics: Animals; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Cytosol; Fura-2; Guanosine 5'-O-(3-Thiotriphosphate); Kidney Tubules, Proximal; Male; Osmolar Concentration; Parathyroid Hormone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Teriparatide; Tetradecanoylphorbol Acetate | 1995 |
The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Bombesin; Genistein; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Isoflavones; Kinetics; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 1995 |
ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP.
Topics: Adenosine Triphosphate; ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Cytosol; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neutrophils; Phosphatidylinositol Phosphates; Phospholipase D; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1994 |
L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms.
Topics: Animals; Animals, Newborn; Calcium Channels; Cholera Toxin; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Pertussis Toxin; Phenylephrine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Mechanisms of PTH-induced rise in cytosolic calcium in adult rat hepatocytes.
Topics: Animals; Bucladesine; Calcium; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Liver; Male; Nifedipine; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Proteins; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Verapamil | 1994 |
Absence of rapid desensitization of the mouse gonadotropin-releasing hormone receptor.
Topics: Animals; Cell Line; Cells, Cultured; DNA, Complementary; Enzyme Activation; Gonadotropin-Releasing Hormone; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Mice; Phosphorylation; Protein Kinase C; Receptors, LHRH; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling.
Topics: Calcium; Cell Line; Cell Membrane Permeability; Diglycerides; Electroporation; Fatty Acids, Nonesterified; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Homeostasis; Humans; Hydrogen-Ion Concentration; Isoflavones; Kinetics; Leukemia, Promyelocytic, Acute; Lymphoma, Large B-Cell, Diffuse; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Signal Transduction; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured; Vanadates | 1994 |
Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation.
Topics: Adenosine Triphosphate; Alkaloids; Calcium; Cell Membrane; Chemotaxis, Leukocyte; Cytochalasin B; Down-Regulation; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Neutrophils; Phospholipase D; Protein Kinase C; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells.
Topics: Animals; Calcium; Cells, Cultured; Cholera Toxin; Dogs; Egtazic Acid; Endothelins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Trachea; Viper Venoms; Virulence Factors, Bordetella | 1994 |
rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.
Topics: ADP Ribose Transferases; Botulinum Toxins; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hepatocyte Growth Factor; Humans; Insulin; KB Cells; Microinjections; Protein Binding; rac GTP-Binding Proteins; rho GTP-Binding Proteins; Tetradecanoylphorbol Acetate | 1994 |
Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells.
Topics: Animals; Arachidonic Acid; Bradykinin; Calcium; Cattle; Cytosol; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ion-Selective Electrodes; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinases; Pulmonary Artery; Saponins; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Arachidonic acid liberation induced by phosphatidic acid endogenously generated from membrane phospholipids in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Lipids; Phosphatidic Acids; Phospholipase D; Phospholipases A; Phospholipases A2; Phospholipids; Rabbits; Tetradecanoylphorbol Acetate | 1994 |
Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins.
Topics: Animals; Calcium; Cell Count; Cells, Cultured; Cytochalasin D; Epidermal Growth Factor; Glucose; Glycogen; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Lactates; Lactic Acid; Liver; Male; Pertussis Toxin; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.
Topics: Animals; Blotting, Western; Bradykinin; Calcium; Cell Membrane; CHO Cells; Cloning, Molecular; Cricetinae; Cytosol; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Immunoblotting; Inositol; Isoenzymes; Kinetics; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thrombin; Transfection; Type C Phospholipases | 1994 |
Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.
Topics: 3T3 Cells; Adenine Nucleotides; Aluminum Compounds; Animals; Arachidonic Acid; Avian Sarcoma Viruses; Benzoquinones; Cell Line, Transformed; Cholera Toxin; Enzyme Induction; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylcholines; Phospholipase D; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1994 |
Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins.
Topics: Acetates; Acetylcysteine; Animals; Cerulenin; Cyclohexenes; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Lovastatin; Male; Mevalonic Acid; Monoterpenes; Palmitic Acid; Palmitic Acids; Peptides; Protein O-Methyltransferase; Protein Prenylation; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Terpenes; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wasp Venoms | 1993 |
Inhibition by the protein kinase C activator 4 beta-phorbol 12-myristate 13-acetate of the prostaglandin F2 alpha-mediated and noradrenaline-mediated but not glucagon-mediated activation of glycogenolysis in rat liver.
Topics: Aluminum Compounds; Animals; Dinoprost; Enzyme Activation; Fluorides; Glucagon; Glucose; Glycogen; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Lactates; Lactic Acid; Liver; Male; Norepinephrine; Phosphorylases; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
The regulation of store-dependent Ca2+ influx in HL-60 granulocytes involves GTP-sensitive elements.
Topics: Biological Transport; Calcium; Cell Line; Granulocytes; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; N-Formylmethionine Leucyl-Phenylalanine; Sodium Fluoride; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides | 1993 |
Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues.
Topics: Cell Membrane Permeability; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; Indoles; Inositol; Inositol Phosphates; Kinetics; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphates; Phosphatidylinositol Phosphates; Phosphorus Radioisotopes; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2.
Topics: Adenosine Triphosphate; Aluminum Compounds; Arachidonic Acid; Blotting, Western; Bucladesine; Calcimycin; Calcium; Cell Differentiation; Cell Line; Cytosol; Electrophoresis, Polyacrylamide Gel; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Activated release of membrane-anchored TGF-alpha in the absence of cytosol.
Topics: Aluminum; Aluminum Compounds; Animals; Cell Membrane; Cell Membrane Permeability; CHO Cells; Cricetinae; Fluorides; Fluorine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection; Transforming Growth Factor alpha | 1993 |
GTP gamma S and phorbol ester act synergistically to stimulate both Ca(2+)-independent secretion and phospholipase D activity in permeabilized human platelets. Inhibition by BAPTA and analogues.
Topics: Affinity Labels; Blood Platelets; Blood Proteins; Calcium; Cells, Cultured; Drug Synergism; Egtazic Acid; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Phosphatidic Acids; Phospholipase D; Phosphoproteins; Phosphorylation; Serotonin; Tetradecanoylphorbol Acetate | 1993 |
Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Inositol Phosphates; Myometrium; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C.
Topics: Amino Acid Sequence; Biological Transport; Cell Membrane; Cell-Free System; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Molecular Sequence Data; Myristates; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Oligopeptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Sodium Dodecyl Sulfate; Tetradecanoylphorbol Acetate | 1993 |
Stimulation of phosphoinositide hydrolysis by muscarinic receptor activation in the rat olfactory bulb.
Topics: Adenylyl Cyclases; Animals; Atropine; Bucladesine; Carbachol; Drug Interactions; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Olfactory Bulb; Phosphatidylinositols; Pirenzepine; Rats; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Cyclic AMP inhibits the respiratory burst of electropermeabilized human neutrophils at a downstream site of protein kinase C.
Topics: Binding Sites; Cyclic AMP; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Respiratory Burst; Signal Transduction; Sodium Dodecyl Sulfate; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Mastoparan stimulates insulin secretion from pancreatic beta-cells by effects at a late stage in the secretory pathway.
Topics: Adenosine Triphosphate; Alkaloids; Amino Acid Sequence; Animals; Calcium; Cell Membrane Permeability; Cyclic AMP; Enzyme Activation; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insulin; Insulin Secretion; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Molecular Sequence Data; Peptides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thionucleotides; Wasp Venoms | 1993 |
Inhibition of receptor signaling to phospholipase D by Clostridium difficile toxin B. Role of Rho proteins.
Topics: ADP Ribose Transferases; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; Cell Line; Clostridioides difficile; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Muscarinic Antagonists; Phospholipase D; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Role of Rho in chemoattractant-activated leukocyte adhesion through integrins.
Topics: Amino Acid Sequence; Animals; Antigens, CD; B-Lymphocytes; Cell Adhesion; Cells, Cultured; Chemotactic Factors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Integrin alpha4beta1; Integrins; Interleukin-8; Mice; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Interleukin; Receptors, Interleukin-8A; Receptors, Lymphocyte Homing; Receptors, Peptide; rhoA GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Cell Adhesion Molecule-1 | 1996 |
GTPgammaS-stimulated phospholipase D activation in human neutrophils occurs by protein kinase C-dependent and -independent pathways but not tyrosine kinases.
Topics: Alkaloids; Benzylidene Compounds; Cell Membrane Permeability; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydroquinones; In Vitro Techniques; Indoles; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nitriles; Phospholipase D; Phosphoproteins; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1996 |
Roles of insulin, guanosine 5'-[gamma-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation.
Topics: 3T3 Cells; Animals; Biological Transport, Active; CHO Cells; Cricetinae; Glucose Transporter Type 4; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Mice; Models, Biological; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation.
Topics: Animals; Bacterial Proteins; Bacterial Toxins; Cell Line; Cell Membrane Permeability; Clostridioides difficile; Cytotoxins; Dose-Response Relationship, Drug; Enzyme Activation; Glycerophospholipids; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Leukemia, Basophilic, Acute; Phosphatidic Acids; Phospholipase D; Rats; Receptors, IgE; Signal Transduction; Streptolysins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Ceramide inhibits phospholipase D in a cell-free system.
Topics: Adenosine Triphosphate; Biological Transport; Cell-Free System; Ceramides; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
Separate upstream and convergent downstream pathways of G-protein- and phorbol ester-mediated Ca2+ sensitization of myosin light chain phosphorylation in smooth muscle.
Topics: Animals; Calcium; Carbachol; Cell Membrane; Cytosol; Femoral Artery; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ileum; In Vitro Techniques; Isoenzymes; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphorylation; Portal Vein; Protein Kinase C; Rabbits; Staphylococcus aureus; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1996 |
Evidence that intracellular phosphatidate may regulate breast cancer cell invasion and metastasis.
Topics: Breast Neoplasms; Female; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Fluid; Neoplasm Invasiveness; Phosphatidic Acids; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of Clostridium difficile toxin A and toxin B on phospholipase D activation in human promyelocytic leukemic HL60 cells.
Topics: ADP-Ribosylation Factors; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Enterotoxins; Enzyme Activation; Glycosylation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Phospholipase D; Recombinant Proteins; rhoA GTP-Binding Protein; Tetradecanoylphorbol Acetate | 1996 |
Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
Topics: Amino Acid Sequence; Calcium; Chemotactic Factors; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Interleukin-8; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Halothane reduces myofilament Ca2+ sensitivity during muscarinic receptor stimulation of airway smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Cell Membrane Permeability; Cytosol; Dogs; Escin; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Halothane; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Protein Kinase C; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Trachea | 1996 |
Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells.
Topics: Animals; Bacterial Proteins; Bacterial Toxins; Calcimycin; Cytotoxins; Dinitrophenols; Flow Cytometry; Glucose; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Release; In Vitro Techniques; Ionophores; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of cytosolic phospholipase A2 by annexin V in differentiated permeabilized HL-60 cells. Evidence of crucial importance of domain I type II Ca2+-binding site in the mechanism of inhibition.
Topics: Annexin A5; Arachidonic Acid; Bacterial Proteins; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Membrane Permeability; Cytosol; Enzyme Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Indoles; Kinetics; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Placenta; Pregnancy; Protein Kinase C; Recombinant Proteins; Streptolysins; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of GTP gamma S-dependent phospholipase D and Rho membrane association by calphostin is independent of protein kinase C catalytic activity.
Topics: Blotting, Western; Cell Membrane; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Indoles; Leukemia; Liposomes; Maleimides; Naphthalenes; Permeability; Phospholipase D; Plants; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
The roles of adenosine 3',5'-cyclic monophosphate-dependent protein kinase A and protein kinase C in stimulus-secretion coupling in AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Line; Cell Membrane Permeability; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Intercellular Signaling Peptides and Proteins; Mice; Peptides; Pituitary Gland, Anterior; Protein Kinase C; Tetradecanoylphorbol Acetate; Wasp Venoms | 1996 |
Order of application determines the interaction between phorbol esters and GTP-gamma-S in dorsal raphe neurons: evidence that the effect of 5-HT is modified upstream of the G protein Ca channel interaction.
Topics: Animals; Calcium Channels; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Protein Kinase C; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Tetradecanoylphorbol Acetate | 1997 |
Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.
Topics: Arachidonic Acid; Astrocytoma; Brain Neoplasms; Calcimycin; Calcium; Carbachol; Carcinogens; Cytosol; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ionophores; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1997 |
Carbamoylcholine regulation of polyphosphoinositide synthesis and hydrolysis in cultured, dispersed, digitonin-permeabilized mouse pancreatic islet cells.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Carbachol; Cells, Cultured; Digitonin; Guanosine 5'-O-(3-Thiotriphosphate); Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Permeability; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Sodium Fluoride; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Involvement of Rho family proteins in prostaglandin F2 alpha-induced phospholipase D activation in the osteoblast-like cell line MC3T3-E1.
Topics: Actins; ADP Ribose Transferases; Animals; Bacterial Proteins; Bacterial Toxins; Botulinum Toxins; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Cell Line; Cell Membrane Permeability; Digitonin; Dinoprost; Enterotoxins; Enzyme Activation; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Osteoblasts; Phospholipase D; Proteins; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Tetradecanoylphorbol Acetate | 1997 |
Activation of endothelin ETA receptors induces phosphorylation of alpha1b-adrenoreceptors in Rat-1 fibroblasts.
Topics: Animals; Calcium; Cell Line; Cell Membrane; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Genistein; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Norepinephrine; Peptides, Cyclic; Phosphorylation; Rats; Receptor, Endothelin A; Receptors, Adrenergic, alpha-1; Receptors, Endothelin; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Characteristics of protein-kinase-C- and ADP-ribosylation-factor-stimulated phospholipase D activities in human embryonic kidney cells.
Topics: ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Cell Line; Digitonin; GTP-Binding Proteins; GTPase-Activating Proteins; Guanine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoenzymes; Kidney; Neomycin; Permeability; Phospholipase D; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C-dependent and Ca2+-dependent mechanisms of secretion from streptolysin O-permeabilized platelets: effects of leakage of cytosolic proteins.
Topics: Bacterial Proteins; Blood Platelets; Blood Proteins; Calcium; Carbon Radioisotopes; Cell Membrane Permeability; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Myosin Light Chains; Phosphoproteins; Phosphorylation; Protein Kinase C; Serotonin; Streptolysins; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cattle; Cells, Cultured; Endothelium, Vascular; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Inositol Polyphosphate 5-Phosphatases; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
Effects of brefeldin A on phosphatidylcholine phospholipase D and inositolphospholipid metabolism in HL-60 cells.
Topics: Adenosine Triphosphate; ADP-Ribosylation Factors; Brefeldin A; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; Galactosyltransferases; Golgi Apparatus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Inositol Phosphates; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylcholines; Phosphatidylinositols; Phospholipase D; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
The role of calmodulin-binding sites in the regulation of the Drosophila TRPL cation channel expressed in Xenopus laevis oocytes by ca2+, inositol 1,4,5-trisphosphate and GTP-binding proteins.
Topics: Animals; Binding Sites; Calcium; Calmodulin; Calmodulin-Binding Proteins; Cell Compartmentation; Drosophila melanogaster; Drosophila Proteins; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol 1,4,5-Trisphosphate; Ion Channels; Kinetics; Membrane Proteins; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Protein Kinase C; Recombinant Proteins; Sulfonamides; Tetradecanoylphorbol Acetate; Transient Receptor Potential Channels; Xenopus laevis | 1998 |
Phospholipase D activity in L1210 cells: a model for oleate-activated phospholipase D in intact mammalian cells.
Topics: ADP-Ribosylation Factors; Animals; Cell Differentiation; Dose-Response Relationship, Drug; Enzyme Activation; Fatty Acids, Unsaturated; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Leukemia L1210; Melitten; Mice; Oleic Acid; Phospholipase D; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Fusion pore expansion in horse eosinophils is modulated by Ca2+ and protein kinase C via distinct mechanisms.
Topics: Animals; Calcium; Cell Degranulation; Cell Membrane; Eosinophils; Exocytosis; Guanosine 5'-O-(3-Thiotriphosphate); Horses; Membrane Fusion; Naphthalenes; Organophosphorus Compounds; Patch-Clamp Techniques; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.
Topics: Animals; Calcium; Enzyme Activation; Exocytosis; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Hypoglycemic Agents; Insulinoma; Islets of Langerhans; Isoenzymes; Mice; Pancreatic Neoplasms; Phosphatidylserines; Potassium Channels; Protein Kinase C; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Tolbutamide; Tumor Cells, Cultured | 1998 |
Regulation of exocytosis from rat peritoneal mast cells by G protein beta gamma-subunits.
Topics: Animals; Bacterial Proteins; beta-Adrenergic Receptor Kinases; Bodily Secretions; Calcium; Cell Membrane Permeability; Cyclic AMP-Dependent Protein Kinases; Detergents; Enzyme Inhibitors; Exocytosis; Eye Proteins; GTP-Binding Protein Regulators; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mast Cells; Peptide Fragments; Peritoneum; Phosphoproteins; Protein Kinase C; Rats; Streptolysins; Tetradecanoylphorbol Acetate | 1998 |
ADP-ribosylation factor proteins mediate agonist-induced activation of phospholipase D.
Topics: Adenosine Triphosphate; ADP Ribose Transferases; ADP-Ribosylation Factor 1; ADP-Ribosylation Factors; Botulinum Toxins; Brefeldin A; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoenzymes; Phospholipase D; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Protein Synthesis Inhibitors; rhoA GTP-Binding Protein; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C-promoted inhibition of Galpha(11)-stimulated phospholipase C-beta activity.
Topics: Animals; Erythrocyte Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Phospholipase C beta; Protein Kinase C; Tetradecanoylphorbol Acetate; Turkeys; Type C Phospholipases | 1999 |
Expression and regulation of phospholipase D isoforms in mammalian cell lines.
Topics: Animals; Cell Differentiation; Cell Line; Cell Membrane; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoenzymes; Magnesium; Mice; Nerve Growth Factor; Neurites; Phospholipase D; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate | 2000 |
Effects of local anesthetics on phospholipase D activity in differentiated human promyelocytic leukemic HL60 cells.
Topics: Anesthetics, Local; Biological Transport; Cell Differentiation; Cell Membrane; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Recombinant Proteins; Tetracaine; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C-mediated phosphorylation and desensitization of human alpha(1b)-adrenoceptors.
Topics: Animals; Binding, Competitive; Calcium; Cell Line; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Indoles; Inositol Phosphates; Membranes; Norepinephrine; Phentolamine; Phosphorylation; Piperazines; Prazosin; Precipitin Tests; Protein Kinase C; Radioligand Assay; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes.
Topics: ADP-Ribosylation Factors; Cinnamates; Drug Synergism; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Isoenzymes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipase D; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein-Tyrosine Kinases; rhoA GTP-Binding Protein; Sulfides; Tetradecanoylphorbol Acetate; Tyrosine; Vanadium Compounds | 1999 |
Downregulation of phospholipase D by protein kinase A in a cell-free system of human neutrophils.
Topics: Adenosine Triphosphate; Catalytic Domain; Cell Membrane; Cell-Free System; Cyclic AMP-Dependent Protein Kinases; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Macromolecular Substances; Neutrophils; Phospholipase D; Phosphorylation; rhoA GTP-Binding Protein; Tetradecanoylphorbol Acetate | 2000 |
Norepinephrine- and phorbol ester-induced phosphorylation of alpha(1a)-adrenergic receptors. Functional aspects.
Topics: Animals; Calcium; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Norepinephrine; Phosphorylation; Photoaffinity Labels; Precipitin Tests; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate | 2000 |
Modulation of N-type calcium channel activity by G-proteins and protein kinase C.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Carcinogens; Cells, Cultured; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Ion Channel Gating; Membrane Potentials; Neurons; omega-Conotoxin GVIA; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate; Thionucleotides | 2000 |
Protein kinase C-stimulated formation of ethanolamine from phosphatidylethanolamine involves a protein phosphorylation mechanism: negative regulation by p21 Ras protein.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies; Cell Line, Transformed; Cell Membrane; Drug Synergism; Enzyme Activation; Ethanolamine; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Hydrolysis; Isoenzymes; Membrane Proteins; Mice; Oncogene Protein p21(ras); Phosphatidylethanolamines; Phospholipase D; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins p21(ras); Tetradecanoylphorbol Acetate | 2000 |
The NADPH oxidase diaphorase activity in permeabilized human neutrophils and granulocytic like PLB-985 cells.
Topics: Cell Line; Cell Membrane Permeability; Dihydrolipoamide Dehydrogenase; Granulocytes; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; NADP; NADPH Oxidases; Neutrophil Activation; Neutrophils; Tetradecanoylphorbol Acetate | 2000 |
The effect of a Rho kinase inhibitor Y-27632 on superoxide production, aggregation and adhesion in human polymorphonuclear leukocytes.
Topics: Adult; Amides; Calcimycin; Calcium; Cell Adhesion; Cell Aggregation; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Indicators and Reagents; Intracellular Signaling Peptides and Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Superoxides; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Activation of phospholipase D by PKC and GTPgammaS in human neuroblastoma cells overexpressing MARCKS.
Topics: Animals; beta-Cyclodextrins; Cell Fractionation; Cyclodextrins; Digitonin; Electroporation; Enzyme Activation; Filipin; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Phospholipase D; Protein Biosynthesis; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling.
Topics: Animals; Enzyme Activation; Erythrocyte Membrane; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Humans; Inositol Phosphates; Phosphorylation; Protein Kinase C; Receptors, Adrenergic, beta; Receptors, Purinergic; RGS Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Turkeys | 2001 |
Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells.
Topics: Carcinogens; Cell Differentiation; Cell Line; Cell Membrane; Cytochrome c Group; Cytosol; Dihydrolipoamide Dehydrogenase; Dose-Response Relationship, Drug; Electron Transport; Electrons; Enzyme Activation; Granulocytes; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Membrane Glycoproteins; Models, Biological; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Phenotype; Phospholipases A; Superoxides; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Time Factors | 2001 |
Modulation of N-type Ca2+ channel current kinetics by PMA in rat sympathetic neurons.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels, N-Type; Dialysis; Electric Conductivity; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Male; Neurons; omega-Conotoxin GVIA; Protein Kinase C; Rats; Rats, Wistar; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate; Thionucleotides | 2001 |
Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin.
Topics: Animals; Blotting, Western; Calcium; Cell Fractionation; CHO Cells; Cholecystokinin; Cricetinae; Cytosol; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanosine 5'-O-(3-Thiotriphosphate); Isoenzymes; Pancreas; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipase D; Protein Kinase C; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 2001 |
A critical protein kinase C phosphorylation site on the 5-HT(1A) receptor controlling coupling to N-type calcium channels.
Topics: Animals; Binding Sites; Calcium Channels; Calcium Channels, N-Type; Carbazoles; Cells, Cultured; Dose-Response Relationship, Drug; Enkephalin, Leucine-2-Alanine; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Indoles; Mice; Mutation; Osmolar Concentration; Phosphorylation; Protein Kinase C; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Tetradecanoylphorbol Acetate | 2002 |
ARNO but not cytohesin-1 translocation is phosphatidylinositol 3-kinase-dependent in HL-60 cells.
Topics: ADP-Ribosylation Factor 1; Biological Transport; Cell Adhesion Molecules; Enzyme Activation; Fungal Proteins; Granulocytes; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Phospholipase D; Tetradecanoylphorbol Acetate | 2002 |
Dynamin-dependent and dynamin-independent processes contribute to the regulation of single vesicle release kinetics and quantal size.
Topics: Animals; Cattle; Chromaffin Cells; Dynamins; Endocytosis; Enzyme Activation; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Nerve Tissue Proteins; Protein Kinase C; src Homology Domains; Tetradecanoylphorbol Acetate | 2002 |
Translocation of pleckstrin requires its phosphorylation and newly formed ligands.
Topics: Blood Platelets; Blood Proteins; Cell Membrane Permeability; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Phosphoproteins; Phosphorylation; Protein Transport; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2002 |
Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cytosol; Deoxyribonuclease I; Depsipeptides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Macromolecular Substances; Magnesium Chloride; Mammals; Marine Toxins; Peptides, Cyclic; Phalloidine; Phospholipase D; Protein Isoforms; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; U937 Cells | 2002 |
Different roles for Gi and Go proteins in modulation of adenylyl cyclase type-2 activity.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Protein Kinase C; Receptors, Adrenergic, alpha-2; Signal Transduction; Spodoptera; Tetradecanoylphorbol Acetate | 2002 |
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase.
Topics: Adenosine Triphosphate; Bacterial Proteins; Cell Fractionation; Cytoplasm; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Humans; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoproteins; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Reactive Oxygen Species; Signal Transduction; Streptolysins; Tetradecanoylphorbol Acetate | 2003 |
8-oxo-7,8-dihydroguanosine triphosphate(8-oxoGTP) down-regulates respiratory burst of neutrophils by antagonizing GTP toward Rac, a small GTP binding protein.
Topics: Adult; Carcinogens; Cells, Cultured; Deoxyguanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; NADPH Oxidases; Neutrophils; rac GTP-Binding Proteins; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 2007 |
Caspase cleavage of phospholipase D1 in vitro alters its regulation and reveals a novel property of the "loop" region.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; Mice; Phospholipase D; Protein Structure, Secondary; Tetradecanoylphorbol Acetate | 2008 |
Bradykinin inhibits the transient outward K+ current in mouse Schwann cells via the cAMP/PKA pathway.
Topics: Adamantane; Animals; Benzenesulfonates; Bradykinin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic CMP; Enzyme Activators; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Membrane Potentials; Mice; Mice, Inbred ICR; Potassium; Potassium Channels, Voltage-Gated; Protein Kinase C; Protein Kinase Inhibitors; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Schwann Cells; Sciatic Nerve; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPγS containing intracellular solution.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Calcimycin; Calcium; Cell Degranulation; Cell Line; Cell Membrane; Electric Capacitance; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Interleukin-1beta; Interleukin-8; Mast Cells; Renal Dialysis; Tetradecanoylphorbol Acetate; Thiazolidines | 2013 |