tetradecanoylphorbol acetate has been researched along with epidermal growth factor in 964 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 305 (31.64) | 18.7374 |
| 1990's | 467 (48.44) | 18.2507 |
| 2000's | 174 (18.05) | 29.6817 |
| 2010's | 17 (1.76) | 24.3611 |
| 2020's | 1 (0.10) | 2.80 |
| Authors | Studies |
|---|---|
| Herschman, HR; Pruss, RM | 1 |
| Marx, JL | 1 |
| Lee, LS; Weinstein, IB | 4 |
| Aharonov, A; Herschman, HR; Passovoy, DS; Pruss, RM | 1 |
| Dicker, P; Rozengurt, E | 3 |
| Brown, KD; Dicker, P; Rozengurt, E | 1 |
| Fusenig, NE; Murray, AW | 1 |
| Frantz, CN; Scher, CD; Stiles, CD | 1 |
| Bozzone, JH; Fisher, PB; Weinstein, IB | 1 |
| Ballotti, R; Chauvel, A; Filloux, C; Lammers, R; Schlessinger, J; Tartare, S; Ullrich, A; Van Obberghen, E | 1 |
| Kitajima, S; Sano, M | 1 |
| Rivedal, E; Sanner, T | 1 |
| Carter, DM; Gottlieb, AB; Krane, JF; Krueger, JG | 1 |
| Ritvos, O; Voutilainen, R | 1 |
| Richards, JS; Wong, WY | 1 |
| Campbell, D; Hall, FL; Pelech, SL; Sanghera, JS; Warburton, D | 1 |
| Ascoli, M; Nelson, S | 1 |
| Hawkins, PT; Jackson, TR; Stephens, LR | 1 |
| Fang, MA; Hahn, TJ; Kujubu, DA | 1 |
| Ghishan, FK; Kikuchi, K; Riedel, B | 1 |
| Park, D; Rhee, SG | 1 |
| Hu, P; Li, W; Schlessinger, J; Skolnik, EY; Ullrich, A | 1 |
| Iwanaga, M; Sano, M | 1 |
| Ide, T; Tsuji, K; Ueno, A | 2 |
| Huebert, C; Kuszynski, C; Rizzino, A; Wilder, PJ | 1 |
| Ido, A; Motomura, M; Nakabayashi, H; Nakata, K; Tamaoki, T | 1 |
| Karnovsky, MJ; Ottlinger, ME; Pukac, LA | 2 |
| Colburn, NH; Pommier, Y; Sun, Y | 1 |
| Hawley, RJ; Scheibe, RJ; Wagner, JA | 1 |
| Andrejauskas-Buchdunger, E; Regenass, U | 1 |
| Kaszkin, M; Kinzel, V; Richards, J | 2 |
| Han, TH; Lamph, WW; Prywes, R | 1 |
| Kast, R; Kaszkin, M; Kinzel, V; Seidler, L | 1 |
| Blatti, SP; Scott, RE | 1 |
| Jones, GJ; Thornley, AL | 1 |
| Kobayashi, T | 1 |
| Edwin, SS; Mitchell, MD | 1 |
| Lee, ME; Perrella, MA; Quertermous, T; Susanni, EE; Temizer, DH; Yoshizumi, M | 1 |
| Borowski, P; Buck, F; Fanick, W; Harbers, M; Hilz, H; Hinsch, KD; Lengyel, H | 1 |
| Albrecht, T; Ball, RL; Carney, DH; James, O; Thompson, WC | 1 |
| Kerr, LD; Magun, BE; Matrisian, LM | 1 |
| Emoto, T; Hishinuma, A; Ichimura, K; Kasai, K; Shimoda, S | 1 |
| Bartlett, JM; Crew, AJ; Langdon, SP; Miller, EP; Miller, WR; Rabiasz, GJ; Scott, WN; Smyth, JF | 1 |
| Banba, N; Emoto, T; Hattori, Y; Hiraiwa, M; Hishinuma, A; Hosoya, T; Ichimura, K; Kasai, K; Shimoda, S; Yamaguchi, F | 1 |
| Bassols, A; Baulida, J; Onetti, R | 1 |
| Armato, U; Carcereri dePrati, A; Menapace, L; Menegazzi, M; Miwa, M; Ribecco, M; Suzuki, H; Testolin, L | 1 |
| Ben-Ari, ET; Bernstein, LR; Colburn, NH | 1 |
| Dumont, JE; Gérard, C; Maenhaut, C; Pohl, V; Vassart, G | 1 |
| Lane, HA; Susa, M; Thomas, G; Vulević, D | 1 |
| Franklin, CC; Kraft, AS | 1 |
| Felder, S; LaVin, J; Schlessinger, J; Ullrich, A | 1 |
| Cambria, RP; Kourembanas, S; Lee, ME; Quertermous, T; Temizer, DH; Yoshizumi, M | 1 |
| Joyce, NC; Meklir, B | 1 |
| Long, GJ; Rosen, JF | 1 |
| Lenormand, P; Magun, BE; Pribnow, D; Rodland, KD | 1 |
| Allinson, ET; Drucker, DJ | 1 |
| Knopf, JL; Lin, AY; Lin, LL | 1 |
| Harris, RC | 2 |
| Cook, SJ; Wakelam, MJ | 1 |
| Dumont, JE; Pirson, I; Reuse, S | 2 |
| Carpenter, G; Hernández-Sotomayor, SM; Mumby, M | 1 |
| Olashaw, NE; Pledger, WJ; Winston, JT | 1 |
| Bates, B; Goldfarb, M; Hofschneider, PH; Roth, WK; Werner, S | 1 |
| Li, M; Morley, P; Tsang, BK | 1 |
| Medcalf, RL; Schleuning, WD | 1 |
| Dlugosz, AA; Yuspa, SH | 1 |
| Bird, TA; Saklatvala, J | 1 |
| Bobik, A; Grinpukel, S; Grooms, A; Millar, JA; Mitchell, A | 1 |
| Kohno, M; Nishizawa, N; Nomoto, H; Tsujimoto, M | 1 |
| Earp, HS; McCune, BK; Prokop, CA | 1 |
| Iwashita, S; Mitsui, K; Senshu-Miyaike, M; Shoji-Kasai, Y | 1 |
| Afar, DE; Bell, JC; Braun, PE; Roder, J; Salzer, JL | 1 |
| Earp, HS; Harden, TK; Hepler, JR; Huckle, WR; Jeffs, RA; Outlaw, HE; Rhee, SG | 1 |
| Beck, D; Favre, S; Gross, N | 1 |
| Hirai, M; Shimizu, N | 1 |
| Bachrach, LK; Burrow, GN; Eggo, MC; Liu, F; Powell, DR; Tram, T | 1 |
| Bradshaw, TD; Gescher, A; Pettit, GR | 1 |
| Bellas, RE; Bendori, R; Farmer, SR | 1 |
| Fletcher, BS; Herschman, HR; Kujubu, DA; Lim, RW; Varnum, BC | 1 |
| Budnik, LT; Mukhopadhyay, AK | 2 |
| Kikuchi, T; Tamm, I | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Arvidson, K; Grafström, RC; Liu, Y; Nilsson, L; Ormstad, K; Sundqvist, K; Toftgård, R | 1 |
| Bohm, S | 1 |
| Crossin, KL | 1 |
| Bachrach, LK; Brown, AL; Burrow, GN; Eggo, MC | 1 |
| Cho, HS; Katzenellenbogen, BS; NG, PA | 1 |
| Kudlow, JE; Mueller, SG | 1 |
| Eggo, MC; Islam, S; Sheppard, MC | 1 |
| Beckmann, JD; Claassen, L; Illig, M; Rennard, SI; Rickard, K; Romberger, D; Takizawa, H | 1 |
| Carney, DH; Fenton, JW; Morris, DL; Nechay, P; Ward, JB; Whorton, EB | 1 |
| Christoffersen, T; Gladhaug, IP; Refsnes, M | 1 |
| de Groot, RP; de Laat, SW; den Hertog, J; Kruijer, W | 1 |
| Georgiadis, C; Laskin, JD | 1 |
| Atlan, H; Markus, M; Panet, R; Snyder, D | 2 |
| Aoki, J; Inoue, K; Sasaki, M; Takio, K; Titani, K; Umeda, M; Utsumi, H | 1 |
| Ide, T; Miyake, E; Sakayama, M; Takasuka, T | 1 |
| Levine, L; Watanabe, M | 1 |
| Kessler, TL; Markus, G | 1 |
| Bruns, K; Chiang, CP; Delgado, M; Denhardt, DT; Fang, Y; Hamilton, RT; Jang, YJ; Nilsen-Hamilton, M; Parfett, CL; Shim, JK | 1 |
| Kaziro, Y; Miyajima, A; Nakafuku, M; Satoh, T | 1 |
| Higashi, K; Hoek, JB | 1 |
| Bradbury, A; Possenti, R; Shooter, EM; Tirone, F | 1 |
| Gill, GN; Rosenfeld, MG; Wells, A; Welsh, JB | 1 |
| Butler, WT; Kasugai, S; Overall, CM; Sodek, J; Wrana, JL; Zhang, Q | 1 |
| Fürstenberger, G; Kaszkin, M; Kinzel, V; Richards, J; Seidler, L | 1 |
| Godwin, AK; Lieberman, MW | 1 |
| Glinsmann-Gibson, BJ; Korc, M | 1 |
| Bonventre, JV; Sellmayer, A; Uedelhoven, WM; Weber, PC | 1 |
| Patel, TB; Rashed, SM | 1 |
| Mackanos, EA; Pettit, GR; Ramsdell, JS | 1 |
| Hatayama, I; Ichihara, A; Sato, K; Tanaka, K; Yamada, Y | 1 |
| Boonstra, J; de Groot, RP; de Laat, SW; den Hertog, J; Kruijer, W; Rijken, PJ; Verkleij, AJ | 1 |
| Brown, AB; Carpenter, G | 1 |
| Kudlow, JE; Paterson, AJ; Raja, RH; Shin, TH | 1 |
| Rizzino, A; Wilder, PJ | 1 |
| Heldin, CH; Miyazono, K; Usuki, K | 1 |
| Desai, NN; Spiegel, S | 1 |
| Ertl, AP; Gill, GN; Hudson, LG | 1 |
| Sandvig, K; van Deurs, B | 1 |
| Greene, MI; Qian, XL; Wada, T | 1 |
| Berkers, JA; Boonstra, J; van Bergen en Henegouwen, PM | 1 |
| L'Allemain, G; Sturgill, TW; Weber, MJ | 1 |
| Chi, TH; Fletcher, B; Herschman, HR; Ma, QF; Varnum, BC | 1 |
| Edwards, DR; Mahadevan, LC | 1 |
| Beltrán, LM; DiGiovanni, J; Imamoto, A | 2 |
| Ascoli, M; Segaloff, DL; Wang, H | 1 |
| Boxer, DC; Cantley, LC; Seifter, JL; Stanton, RC; Zimmerman, E | 1 |
| Bruce, SA; Bury, MA; Okeda, T; Ts'o, PO; Ueo, H; Yokogawa, Y | 1 |
| Bock, KW; Kobusch, AB | 1 |
| Franco, R; Rosenfeld, MG | 1 |
| Heath, JK; Hirst, EA; Mahadevan, LC; Rathjen, PD; Wills, AJ | 1 |
| Bonventre, JV; Gronich, JH; Nemenoff, RA | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Decker, SJ; Ellis, C; Pawson, T; Velu, T | 1 |
| Cao, XM; Gaffney, R; Gashler, A; Hay, RV; Koski, RA; McKiernan, M; Morris, CF; Sukhatme, VP | 1 |
| Lenormand, P; Magun, BE; Muldoon, LL; Rodland, KD | 1 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A | 1 |
| Davis, BB; Duniec, ZM; Eling, TE; Wong, YH; Zenser, TV | 1 |
| Nori, M; Shawver, LK; Weber, MJ | 1 |
| Barbu, V; Dautry, F | 1 |
| Fukumoto, Y; Hori, Y; Kaibuchi, K; Oku, N; Takai, Y | 1 |
| Blasi, F; Johnsen, M; Nerlov, C; Rørth, P | 1 |
| Amano, F; Chatani, Y; Kohno, M; Nishizawa, N; Nomoto, H; Nozawa, Y; Okano, Y; Tanaka, E | 1 |
| Magun, BE; Muldoon, LL; Pribnow, D; Rodland, KD | 1 |
| Satake, T | 1 |
| Amino, S; Ishiwata, Y; Kakai, Y; Kawamura, T; Nakano, T; Saito, S; Satake, T; Sato, T; Yasu, N | 1 |
| Barnes, D; Cosola-Smith, C; Rawson, C | 1 |
| McGivan, JD; Moule, SK | 1 |
| Teitelbaum, I | 2 |
| Pasqualini, JR; Sumida, C | 1 |
| Goldberg, HJ; Margolis, BL; Schlessinger, J; Skorecki, KL; Viegas, MM | 1 |
| Dumont, JE; Maenhaut, C; Reuse, S | 1 |
| Honegger, AM; Schlessinger, J; Schmidt, A; Ullrich, A | 1 |
| Davis, RJ; Northwood, IC | 2 |
| Hirai, M; Kobayashi, M; Shimizu, N | 1 |
| Gill, GN; Hudson, LG; Thompson, KL; Xu, J | 1 |
| Moolenaar, WH; van Iersel, MJ; Verheijden, GF; Verlaan, I | 1 |
| Chen, WS; Gill, GN; Herbst, JJ; Lazar, CS; Lund, KA; Rosenfeld, MG; Walsh, BJ; Walton, GM; Welsh, JB; Wiley, HS | 1 |
| Conricode, KM; Ochs, RS | 1 |
| Burstein, DE; Lacal, JC; Pellicer, A; Thomson, TM; Trotta, RJ | 1 |
| Hootman, SR; Verme, TB | 1 |
| Fujiwara, K; Hirata, K | 1 |
| Clémente, F; Estival, A; Oustry, P; Pradayrol, L; Vaysse, N | 1 |
| Carroll, SL; Fahrner, TJ; Milbrandt, J | 1 |
| Desai, NN; Murphey, JM; Spiegel, S; Zhang, H | 1 |
| Fertel, RH; Gabbe, SG; Iams, JD; Kniss, DA; Mershon, J; Sonek, J; Su, HC; Waxman, M | 1 |
| Goodrum, DD; Sachs, G; Wheeler, LA | 1 |
| Earp, HS; Grisham, JW; Raymond, VW | 1 |
| Olson, JE; Pledger, WJ | 1 |
| Asawa, T; Komiya, I; Nagasawa, Y; Shimizu, Y; Shinoda, T; Takasu, N; Yamada, T | 1 |
| Ramsdell, JS | 1 |
| Christoffersen, T; Gladhaug, IP | 1 |
| Bancroft, C; Bandyopadhyay, SK; Jackson, AE | 1 |
| Baliga, BS; Barnard, JA; Borowitz, SM | 2 |
| Koga, M; Musgrove, EA; Sutherland, RL | 1 |
| Owen, NE | 1 |
| De Laat, SW; Defize, LH; Moolenaar, WH | 1 |
| Campisi, J; Dean, M; Henkle, C; Levine, RA; Ran, W | 1 |
| Eakes, AT; Pike, LJ | 1 |
| Bass, G; Wedner, HJ | 1 |
| Fujiki, H; Lazzaro, M; Levine, L; Tashjian, AH | 1 |
| Machado, AJ; Mallea, LE; Navaroli, F; Rommerts, FF | 1 |
| Kuratomi, Y; Kuwano, M; Masumi, S; Ono, M; Yasutake, C | 1 |
| Abe, K; Ito, H; Ochiai, A; Tahara, E; Yamamoto, T; Yanaihara, N; Yasui, W | 1 |
| Ormerod, EJ; Rudland, PS | 1 |
| Funahashi, I; Indo, K; Matsuoka, T; Miyaji, H; Nakasho, K | 1 |
| Anderson, NG; Hanson, PJ; Hatt, JF; Shaw, GP | 1 |
| Jumblatt, MM; Matkin, ED; Neufeld, AH | 1 |
| Casnellie, JE; Hinkle, PM; Kaji, H | 1 |
| Atwell, MM; Hanson, PJ | 1 |
| Chang, CC; Madhukar, BV; Oh, SY; Trosko, JE; Wade, M | 1 |
| Bjorge, JD; Kudlow, JE; Mills, GB; Paterson, AJ | 1 |
| Buchou, T; Charollais, RH; Fagot, D; Mester, J | 1 |
| Decker, SJ; Harris, P | 1 |
| Borst, SE; Catherwood, BD | 1 |
| Bachrach, LK; Burrow, GN; Eggo, MC; Liu, FR | 1 |
| Böhmer, RM | 1 |
| Kuppuswamy, D; Pike, LJ | 1 |
| Jaken, S; Karasaki, Y; Komoriya, A; Zoon, KC | 1 |
| Chakravarthy, BR; Durkin, JP; Franks, DJ; Whitfield, JF | 1 |
| Cosenza, SC; Owen, TA; Soprano, DR; Soprano, KJ | 1 |
| Berry, M; Chambon, P; Imler, JL; Nunez, AM | 1 |
| Fisch, TM; Prywes, R; Roeder, RG | 2 |
| Chepenik, KP | 1 |
| de Kretser, DM; Gonzales, GF; Risbridger, GP | 1 |
| Bjorge, JD; Kudlow, JE; Paterson, AJ | 1 |
| Arai, K; Collins, M; Miyajima, A; Wang, HM | 1 |
| Day, RN; Maurer, RA | 1 |
| Cantley, L; Whitman, M | 1 |
| Cho, KO; Jackson-Grusby, L; Minsk, B; Palmieri, S; Skarnes, WC; Wagner, JA | 1 |
| Gill, GN; Hudson, LG; Santon, JB | 1 |
| Campisi, J; Castellot, JJ; Karnovsky, MJ; Kim-Park, HY; Levine, RA; Pukac, LA; Wright, TC | 1 |
| Bernstein, LR; Colburn, NH | 1 |
| Fabbro, D; Olivier, AR; Susa, M; Thomas, G | 1 |
| Galway, AB; Hsueh, AJ; Ny, T; Oikawa, M | 1 |
| Blay, J; Hollenberg, MD | 1 |
| Benveniste, R; Ilekis, J | 2 |
| Arcidiacono, A; Avola, R; Condorelli, DF; Dell'Albani, P; Ingrao, F; Kaczmarek, L; Magrì, G; Malaguarnera, L; Messina, A; Nicoletti, F | 1 |
| Gittinger, CK; King, CS; Landreth, GE; Pearson, E; Smith, DS | 1 |
| Cunningham, TW; Kuppuswamy, D; Pike, LJ | 1 |
| Boonstra, J; Ponec, M | 1 |
| Hoshi, M; Nishida, E; Sakai, H | 2 |
| Green, J; Muallem, S | 1 |
| Abidi, TF; Laskin, JD; Mermelstein, FH | 1 |
| Czerwiec, FS; Majercik, MH; Puett, D | 1 |
| Ciment, G; Machida, CM; Magun, BE; Matrisian, L; Rodland, KD | 1 |
| Dobashi, K; Greene, MI; Weiner, DB | 1 |
| Alfonzo, RG; Gonzalez, FA; Heppel, LA; Toro, JR | 1 |
| Aizu, E; Kato, R; Nakadate, T; Nishikawa, K; Yamamoto, S | 1 |
| Cavailles, V; Garcia, M; Rochefort, H | 1 |
| Mitsumata, M; Nishida, K; Tomikawa, M; Yoshida, Y | 1 |
| Shimizu, N; Shimizu, Y | 1 |
| Hall, A; Morris, JD; Price, BD | 1 |
| Alitalo, K; Beguinot, L; Lehtola, L; Lehväslaiho, H; Sistonen, L | 1 |
| Jirtle, RL; Meyer, SA | 1 |
| Kremer, S; Margolis, B; Skorecki, K | 1 |
| Banker, D; Herschman, HR | 1 |
| Heasley, LE; Johnson, GL | 1 |
| Earp, HS; Grisham, JW; Lee, DC; Raymond, VW | 1 |
| Kobrin, MS; Kudlow, JE; Mueller, SG; Paterson, AJ | 1 |
| Engström, W; Hyldahl, L; Larsson, O; Newman, EL; Rees, AR | 1 |
| Ianacone, J; Rodan, GA; Rodan, SB; Thiede, MA; Wesolowski, G | 1 |
| Marais, RM; Mitchell, FE; Parker, PJ | 1 |
| Gibbs, TA; Jirtle, RL; Meyer, SA | 1 |
| Lund, KA; Walsh, BJ; Wiley, HS | 1 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Hosoya, T; Kasai, K; Koizumi, N; Ohmori, T; Shimoda, S | 1 |
| Barritault, D; Chua, CC; Geiman, DE; Ladda, RL | 1 |
| Pike, LJ; Walker, DH | 1 |
| Frisch, SM; Ruley, HE | 1 |
| Beckner, SK; Darfler, FJ; Lin, MC | 1 |
| Banfić, H; Gatalica, Z | 1 |
| Hamilton, JA; Lingelbach, SR; Vairo, G | 1 |
| Hornsby, PJ; McAllister, JM | 1 |
| Earp, HS; Harden, TK; Hepler, JR | 1 |
| Dumont, JE; Roger, P; Taton, M; Van Sande, J | 1 |
| Anderson, DJ; Orit, S; Stein, R | 1 |
| Jalkanen, J; Pekonen, F; Ranta, T; Ritvos, O; Stenman, UH | 1 |
| Berry, AR; Earp, HS; Grisham, JW; Harris, J; Hepler, JR; Lee, LW; McCune, BK; Miller, A; Petch, LA; Raymond, VW | 1 |
| Sassone-Corsi, P; Verma, IM; Visvader, J | 1 |
| Boynton, AL; Hill, TD; Kindmark, H | 1 |
| Beguinot, L; Hanover, JA; Ito, S; Pastan, I; Richert, ND; Willingham, MC | 1 |
| Cremins, J; Halegoua, S; McTigue, M | 1 |
| Fujiki, H; Levine, L | 1 |
| Beguinot, L; Hanover, JA; Pastan, IH; Willingham, MC | 1 |
| Honegger, P | 1 |
| Blumberg, PM; Herald, CL; Pettit, GR; Sako, T; Yuspa, SH | 1 |
| Akiyama, T; Ogawara, H; Saito, T; Toyoshima, K; Yamamoto, T | 1 |
| Inagaki, M; Kobayashi, T; Nakamura, H; Nakayama, T; Nishizawa, K; Ohtsuka, K; Sato, C | 1 |
| Armato, U; Menapace, L; Romano, F | 1 |
| Jaffe, EA; Moscatelli, DA; Rifkin, DB | 1 |
| Bell, RM; Czech, MP; Davis, RJ; Ganong, BR | 1 |
| Bachrach, LK; Burrow, GN; Eggo, MC; Mak, WW | 1 |
| Davis, R; Like, B; Massagué, J | 1 |
| Fearn, JC; King, AC | 1 |
| Czech, MP; Davis, RJ | 2 |
| Frelin, C; Lazdunski, M; Vigne, P | 1 |
| Gescher, A | 1 |
| Kruijer, W; Schubert, D; Verma, IM | 1 |
| Abe, E; Chida, K; Hashiba, H; Kamata, N; Kuroki, T; Sasaki, K; Suda, T | 1 |
| Coughlin, SR; Giels, GM; Lee, WM; Williams, LT; Williams, PW | 1 |
| Clark, AJ; Ishii, S; Merlino, GT; Pastan, I; Richert, N | 1 |
| Bowen-Pope, DF; Eide, BL; Krebs, EG; Pike, LJ; Ross, R | 1 |
| Kraft, AS | 1 |
| Costa, SD; Eppenberger, U; Fabbro, D; Küng, W; Roos, W | 1 |
| Carpenter, CD; Chen, WS; Evans, RM; Gill, GN; Lazar, CS; Lin, CR; Rosenfeld, MG | 1 |
| Jue, SF; Magun, BE; Rodland, KD | 1 |
| Paris, S; Pouysségur, J | 1 |
| Moolenaar, WH | 1 |
| DeLisi, C; Gex-Fabry, M | 1 |
| Macara, IG | 1 |
| Cooper, HL; Feuerstein, N; Sahai, A; Salomon, DS | 1 |
| Selinfreund, R; Wharton, W | 1 |
| Cooper, JA; King, CS | 1 |
| Beatty, S; Bishop, R; Blackshear, PJ; Herschman, HR; Lim, R; Martinez, R; Weber, MJ | 1 |
| Gainer, HS; Murray, AW | 1 |
| Jetten, AM; Shirley, JE | 1 |
| Babiss, LE; Fisher, PB | 1 |
| Komoda, T; Koyama, I; Kumegawa, M; Kurata, M; Nagata, A; Sakagishi, Y | 1 |
| Dumont, JE; Reuse, S; Roger, PP; Vassart, G | 1 |
| Ober, SS; Pardee, AB | 1 |
| Nishida, E; Sakai, H; Shinohara, Y | 1 |
| Hesketh, TR; Metcalfe, JC; Moore, JP; Morris, JD | 1 |
| Kaplan, DR; Morrison, DK; Rapp, U; Roberts, TM | 1 |
| Huang, M; Kamata, N; Kuroki, T; Nose, K | 1 |
| Gurtler, V; Wark, JD | 1 |
| Connelly, PA; Garrison, JC; Hewlett, EL; Johnson, RM; Pobiner, BF; Sisk, RB | 1 |
| Iwashima, A; Kitagawa, K; Nishino, H | 1 |
| Prywes, R; Roeder, RG | 1 |
| Kvedar, J; Levine, L | 1 |
| Aoyagi, T; Fukaya, T; Koizumi, H; Nemoto, O; Suya, H | 1 |
| Akimoto, K; Emoto, T; Hiraiwa, M; Kasai, K; Shimoda, S; Takaoka, T | 1 |
| McGinn, MT; Mullin, JM | 2 |
| Shimizu, Y; Takasu, N; Yamada, T | 2 |
| Abe, Y; Hasegawa, Y; Ibuki, Y; Igarashi, M; Miyamoto, K; Suzuki, T; Ui, M | 1 |
| Bonventre, JV; Kremer, SG; Kudlow, JE; Margolis, BL; Skorecki, KL | 1 |
| Di Francesco, P; Gallinari, P; Liboi, E; Pelosi, E; Peschle, C; Petrini, M; Rossi, GB; Sposi, NM; Testa, U | 1 |
| Gray, GM; Macara, IG | 1 |
| Berent, E; Dull, TJ; Livneh, E; Prywes, R; Schlessinger, J; Ullrich, A | 1 |
| de Laat, SW; Moolenaar, WH; Tilly, BC; van Paridon, PA; Verlaan, I | 1 |
| Colburn, NH; Nakamura, Y; Smith, BM; Wendel, EJ; Winterstein, D | 1 |
| Lorenzo, JA; Sousa, S | 1 |
| Bravo, R; Burckhardt, J; Curran, T; Müller, R | 1 |
| Albert, PR; Tashjian, AH | 1 |
| Gelmann, EP; Lippman, ME; Wilding, G | 1 |
| Kazakoff, P; Rizzino, A; Ruff, E | 1 |
| Carpenter, G; Wahl, M | 2 |
| Vila, J; Weber, MJ | 1 |
| Dinh, TH; Magun, BE; Muldoon, LL; Rodland, KD | 1 |
| Berchuck, A; Casey, ML; MacDonald, PC; Milewich, L | 1 |
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| Dabrowski, A; Daniluk, J | 1 |
| Choi, HK; Choi, HS; Ermakova, SP; Kusaykin, MI; Lee, NY; Shevchenko, NM; Zvyagintseva, TN | 1 |
| Bode, AM; Cho, YY; Dong, Z; Kang, NJ; Kim, HG; Lee, KW; Oh, SM | 1 |
| Kloog, Y; Levy, R; Makovski, V; Raz, A; Shalom-Feuerstein, R | 1 |
| Chen, X; Li, J; Peng, S; Tai, P; Xia, G; Xu, B; Yan, J; Zhang, M; Zhou, B | 1 |
| Leithe, E; Rivedal, E; Sirnes, S | 1 |
| Cora, EM; Maihle, NJ; Negron-Vega, L; Nieves-Alicea, R; Perez-Torres, M; Valle, BL | 1 |
| Kjenseth, A; Leithe, E; Rivedal, E; Sirnes, S | 1 |
| Adolfo García-Sáinz, J; Alcántara-Hernández, R | 1 |
| Bessette, DC; Chen, SC; Khanna, RS; Pallen, CJ; Samayawardhena, LA | 1 |
| Bode, AM; Cho, YY; Dong, Z; Malakhova, ML; Pugliese, A; Yao, K | 1 |
| Huot, ME; Richard, S; Vogel, G | 1 |
| Fujino, H; Kawashima, T; Kiuchi, Y; Matsumoto, I; Matsuzawa, Y; Murayama, T; Nakamura, H; Toyomura, K | 1 |
| Andersen, JN; Anjum, R; Feldman, AS; Gygi, SP; Hendrickson, RC; Keilhack, H; Kraus, M; Krauss, S; Kubota, K; Kunz, RC; Nagashima, K; Paweletz, C; Rush, J; Villén, J; Wu, CL; Yu, Y | 1 |
| Cowan, BJ; Cowan, KN; Laird, DW; Langlois, S; Shao, Q | 1 |
| Bae, HS; Chang, GT; Kim, JH; Lee, CJ; Lee, HJ; Lee, SY; Seok, JH | 1 |
| Ahn, SG; Choi, HK; Choi, HS; Khanal, P; Namgoong, GM; Sohn, H; Yoon, JH | 1 |
| Chang, GT; Kim, JH; Lee, CJ; Lee, HJ; Lee, SY; Seok, JH; Shin, HD; Sikder, MA | 1 |
| Kim, KD; Lee, CJ; Lee, HJ; Lee, SY; Lim, SP; Sikder, A | 1 |
| Curry, TE; Jo, M; Li, F; Liu, J | 1 |
| Armbruster, N; Bell, GW; Cermeno, E; Dang, M; Hartmann, M; Herrlich, A; Lauffenburger, DA; Lodish, HF; Miller, MA; Root, DE | 1 |
| Bernal, AL; Hudson, CA; McArdle, CA; Wouters, E | 1 |
| Lee, CJ; Lee, HJ; Park, SH; Ryu, J; Seo, HS; Yoon, YP | 1 |
| Hong, JH; Kim, YS; Lee, CJ; Lee, HJ; Lee, SK; Park, JS; Shin, YJ; Son, KH; Yoon, YP | 1 |
| Sonnenberg, A; Te Molder, L | 1 |
| Bane, KL; Corum, SL; Danielpour, D; Kao, HY; Shankar, E; Song, K; Wang, H | 1 |
| Audet, N; Bonin, H; Bouvier, M; Devost, D; Hébert, TE; Kobayashi, H; Le Gouill, C; Lukashova, V; Zhou, C | 1 |
| Ma, Y; Shi, H; Yi, Y; Zhang, T | 1 |
| Harris, RA; Lundberg, K; Tarasova, NK; Ytterberg, AJ; Zhang, XM; Zubarev, RA | 1 |
| Byun, S; Jang, YJ; Kim, YA; Lee, JS; Oh, Y | 1 |
| Adewumi, I; Beacon, TH; Davie, JR; Hu, P; Jia, S; López, C; Sharma, KL; Xu, W | 1 |
9 review(s) available for tetradecanoylphorbol acetate and epidermal growth factor
| Article | Year |
|---|---|
Phosphoinositide metabolism and the control of cell proliferation.
Topics: Cell Division; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; Insulin; Oncogenes; Phosphatidylinositols; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1989 |
Effects of growth factors on intracellular pH regulation.
Topics: Amiloride; Animals; Calcium; Cell Line; Cell Membrane Permeability; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Growth Substances; Humans; Hydrogen; Hydrogen-Ion Concentration; Insulin; Lymphocytes; Mice; Mitogens; Models, Molecular; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Cell Surface; Sodium; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1986 |
A multistage model for human colon carcinoma development integrating cell culture studies with pathology.
Topics: Adenoma; Animals; Cell Division; Cell Line; Cells, Cultured; Colonic Neoplasms; Culture Techniques; Deoxycholic Acid; Epidermal Growth Factor; Humans; Models, Biological; Plasminogen Activators; Precancerous Conditions; Tetradecanoylphorbol Acetate | 1985 |
The rat prolactin gene: a target for tissue-specific and hormone-dependent transcription factors.
Topics: Animals; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Epidermal Growth Factor; Gene Expression Regulation; Genes; Genes, Immediate-Early; Neurotransmitter Agents; Nucleic Acid Conformation; Organ Specificity; Pituitary Gland, Anterior; Prolactin; Promoter Regions, Genetic; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription Factor Pit-1; Transcription Factors; Transcriptional Activation | 1994 |
Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells.
Topics: Animals; Arachidonic Acid; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Dietary Fats; Enzyme Activation; Epidermal Growth Factor; Epithelium; ErbB Receptors; Fatty Acids, Unsaturated; Female; Isoenzymes; Linoleic Acid; Linoleic Acids; Mammary Glands, Animal; Mice; Models, Biological; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinogens; Cell Transformation, Neoplastic; Clone Cells; Epidermal Cells; Epidermal Growth Factor; Epidermis; Gene Expression Regulation, Neoplastic; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Phenotype; Protein Biosynthesis; Proteins; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Topics: Aromatase; Breast Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Epidermal Growth Factor; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2002 |
Cell signaling and gene regulation of human 12(S)-lipoxygenase expression.
Topics: Arachidonate 12-Lipoxygenase; Base Sequence; Epidermal Growth Factor; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Signal Transduction; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2003 |
[Mechanism for activation of heparin-binding EGF-like growth factor induced by stimuli].
Topics: Animals; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Signal Transduction; Tetradecanoylphorbol Acetate | 2004 |
955 other study(ies) available for tetradecanoylphorbol acetate and epidermal growth factor
| Article | Year |
|---|---|
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.
Topics: Cell Division; Cell Line; Colchicine; Epidermal Growth Factor; Insulin; Kinetics; Mitogens; Mutation; Peptides; Prostaglandins F; Tetradecanoylphorbol Acetate | 1977 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Growth Factor; Humans; Neoplasms; Ornithine Decarboxylase; Phenobarbital; Plasminogen Activators; Receptors, Drug; Saccharin; Smoking; Tetradecanoylphorbol Acetate | 1978 |
Epidermal growth factor, like phorbol esters, induces plasminogen activator in HeLa cells.
Topics: Cycloheximide; Dactinomycin; Epidermal Growth Factor; HeLa Cells; Peptides; Phorbols; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1978 |
Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors.
Topics: Binding, Competitive; Cell Membrane; Epidermal Growth Factor; HeLa Cells; Kinetics; Peptides; Phorbol Esters; Phorbols; Receptors, Drug; Tetradecanoylphorbol Acetate | 1978 |
Mitogens for murine embryo cell lines.
Topics: Animals; Cell Line; Contact Inhibition; Culture Media; Embryo, Mammalian; Epidermal Growth Factor; Growth Substances; Hydrocortisone; Insulin; Mice; Mice, Inbred Strains; Mitogens; Prostaglandins F; Tetradecanoylphorbol Acetate | 1978 |
Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors.
Topics: Blood; Cells, Cultured; Contact Inhibition; Culture Media; DNA; Drug Synergism; Epidermal Growth Factor; Growth Substances; Insulin; Mitogens; Phorbols; Tetradecanoylphorbol Acetate | 1978 |
Inhibition of epidermal growth factor binding to surface receptors by tumor promotors.
Topics: Animals; Binding Sites; Cell Line; DNA; Drug Synergism; Epidermal Growth Factor; Glycolysis; Kinetics; Mice; Peptides; Phorbols; Receptors, Drug; Temperature; Tetradecanoylphorbol Acetate | 1979 |
Binding of epidermal growth factor to primary and permanent cultures of mouse epidermal cells: inhibition by tumor-promoting phorbol esters.
Topics: Animals; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Mice; Neoplasms, Experimental; Peptides; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors.
Topics: Animals; Blood; Cell Division; Cell Line; DNA; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Growth Substances; Insulin; Mice; Phorbols; Somatomedins; Tetradecanoylphorbol Acetate | 1979 |
Mechanism of tumor promoter inhibition of cellular binding of epidermal growth factor.
Topics: Epidermal Growth Factor; HeLa Cells; Humans; Kinetics; Peptides; Phorbols; Receptors, Drug; Tetradecanoylphorbol Acetate | 1979 |
Tumor promoters and epidermal growth factor stimulate anchorage-independent growth of adenovirus-tranformed rat embryo cells.
Topics: Adenoviruses, Human; Animals; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Clone Cells; Dexamethasone; Diterpenes; Embryo, Mammalian; Epidermal Growth Factor; Peptides; Phorbols; Protease Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tretinoin | 1979 |
Retinoids enhance mitogenesis by tumour promotor and polypeptide growth factors.
Topics: Animals; Cell Division; Cell Line; Cricetinae; DNA; DNA Replication; Epidermal Growth Factor; Growth Substances; Insulin; Kinetics; Mice; Mice, Inbred BALB C; Peptides; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin; Vasopressins | 1979 |
Activation of insulin-epidermal growth factor (EGF) receptor chimerae regulates EGF receptor binding affinity.
Topics: Cell Line; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Insulin; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Protein-Tyrosine Kinases; Temperature; Tetradecanoylphorbol Acetate | 1992 |
Activation of microtubule-associated protein kinase in PC12D cells in response to both fibroblast growth factor and epidermal growth factor and concomitant stimulation of the outgrowth of neurites.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Neurites; PC12 Cells; Protein Kinases; Tetradecanoylphorbol Acetate | 1992 |
Regulation of gap junctional communication in Syrian hamster embryo cells by retinoic acid and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Cell Communication; Cell Line; Cell Line, Transformed; Cricetinae; Cyclic AMP; Embryo, Mammalian; Epidermal Growth Factor; Intercellular Junctions; Mesocricetus; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
The insulin-like growth factor I receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor receptor.
Topics: Antibodies, Monoclonal; Calcimycin; Epidermal Growth Factor; Epidermis; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Keratinocytes; Precipitin Tests; Protein Kinases; Psoriasis; Receptors, Cell Surface; Receptors, Somatomedin; Tetradecanoylphorbol Acetate | 1992 |
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Topics: Adrenodoxin; Analysis of Variance; Blotting, Northern; Cholera Toxin; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Choriocarcinoma; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; Nucleic Acid Hybridization; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Induction of prostaglandin H synthase in rat preovulatory follicles by gonadotropin-releasing hormone.
Topics: Animals; Cells, Cultured; Cyclic AMP; Dinoprost; Enzyme Induction; Epidermal Growth Factor; Estrogens, Non-Steroidal; Female; Genistein; Gonadotropin-Releasing Hormone; Isoflavones; Kinetics; Luteinizing Hormone; Ovarian Follicle; Progesterone; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Sexual Maturation; Tetradecanoylphorbol Acetate | 1992 |
Identification of epidermal growth factor Thr-669 phosphorylation site peptide kinases as distinct MAP kinases and p34cdc2.
Topics: Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Molecular Sequence Data; Oocytes; Peptide Fragments; Phosphorylation; Phosphothreonine; Protein Kinases; Starfish; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1992 |
Epidermal growth factor, a phorbol ester, and 3',5'-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 Leydig tumor cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cyclic AMP; Dactinomycin; DNA; Epidermal Growth Factor; Humans; Kinetics; Leydig Cell Tumor; Receptors, LH; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1992 |
Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells.
Topics: 1-Phosphatidylinositol 4-Kinase; 3T3 Cells; Alprostadil; Animals; Bombesin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Growth Substances; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Hormones; Inositol Phosphates; Insulin; Insulin-Like Growth Factor I; Kinetics; Mice; Phosphates; Phosphatidylinositol 3-Kinases; Phosphorus Radioisotopes; Phosphotransferases; Platelet-Derived Growth Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Vasopressins | 1992 |
The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells.
Topics: Animals; Bone Neoplasms; Calcium; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Immediate-Early Proteins; Inositol Phosphates; Mitosis; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinases; Radioimmunoassay; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Transcription Factors; Tritium; Tumor Cells, Cultured; Zinc Fingers | 1992 |
Epidermal growth factor up-regulates intestinal Na+/H+ exchange activity.
Topics: Adenosine Triphosphate; Amiloride; Animals; Biological Transport; Calmodulin; Carrier Proteins; Cyclic AMP; Epidermal Growth Factor; In Vitro Techniques; Jejunum; Kinetics; Microvilli; Rats; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1992 |
Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Line; Chromatography, Affinity; Colforsin; Cyclic AMP; Epidermal Growth Factor; Immunoblotting; Kinetics; Molecular Sequence Data; Oncogene Proteins; Organ Specificity; PC12 Cells; Phosphorylation; Precipitin Tests; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Serine; Tetradecanoylphorbol Acetate; Threonine; Type C Phospholipases | 1992 |
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Humans; Mice; Oncogene Proteins; Organ Specificity; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Signal Transduction; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Transfection; Vanadates | 1992 |
Requirement for specific protein kinase activities during the rapid redistribution of F-actin that precedes the outgrowth of neurites in PC12D cells.
Topics: Actins; Animals; Bucladesine; Carbazoles; Colchicine; Cytochalasin B; Cytoskeleton; Epidermal Growth Factor; Fibroblast Growth Factor 2; Indole Alkaloids; Isoquinolines; Nerve Growth Factors; Neurons; Protein Kinases; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Inhibitory effect of taxol, a microtubule stabilizing agent, on induction of DNA synthesis is dependent upon cell lines and growth factors.
Topics: Alkaloids; Animals; Blood; Cell Line; Culture Media; DNA; Epidermal Growth Factor; Fibroblasts; Humans; Microtubules; Paclitaxel; Rats; Signal Transduction; Tetradecanoylphorbol Acetate | 1992 |
Effects of cell density and phorbol esters on the expression of epidermal growth factor receptors.
Topics: Cell Count; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; KB Cells; Kinetics; Phorbol 12,13-Dibutyrate; Tetradecanoylphorbol Acetate | 1991 |
A possible mechanism of inverse developmental regulation of alpha-fetoprotein and albumin genes. Studies with epidermal growth factor and phorbol ester.
Topics: Albumins; alpha-Fetoproteins; Blotting, Northern; Chloramphenicol O-Acetyltransferase; DNA; Drug Synergism; Enhancer Elements, Genetic; Epidermal Growth Factor; Humans; Plasmids; Promoter Regions, Genetic; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1992 |
Heparin suppresses specific second messenger pathways for protooncogene expression in rat vascular smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Bucladesine; Calcimycin; Cell Cycle; Cells, Cultured; DNA; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Genes, myc; Heparin; Muscle, Smooth, Vascular; Protein Kinase C; Proto-Oncogenes; Rats; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate | 1992 |
Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage.
Topics: Animals; Benzoyl Peroxide; Catalase; Cell Division; Cell Line, Transformed; DNA; DNA Damage; Epidermal Growth Factor; Genes, fos; Genes, jun; Glutathione Peroxidase; Lyngbya Toxins; Mice; Mice, Nude; Neoplasm Transplantation; RNA; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1992 |
NGF induces the expression of the VGF gene through a cAMP response element.
Topics: Animals; Base Sequence; Blotting, Northern; Bucladesine; Cloning, Molecular; Cyclic AMP; Cyclic AMP Response Element Modulator; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Gene Expression; Genomic Library; Molecular Sequence Data; Nerve Growth Factors; Neuropeptides; Oligodeoxyribonucleotides; PC12 Cells; Promoter Regions, Genetic; Proteins; Rats; Repressor Proteins; Restriction Mapping; RNA Splicing; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1992 |
Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.
Topics: 3T3 Cells; Alkaloids; Animals; Antineoplastic Agents; Cells, Cultured; Epidermal Growth Factor; Gene Expression; Genes, fos; Mice; Mice, Inbred BALB C; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Proposed role of phosphatidic acid in the extracellular control of the transition from G2 phase to mitosis exerted by epidermal growth factor in A431 cells.
Topics: Drug Synergism; Epidermal Growth Factor; Extracellular Space; Fatty Acids; G2 Phase; Growth Inhibitors; Humans; Mitosis; Phosphatidic Acids; Phospholipase D; Phospholipids; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter.
Topics: Base Sequence; Binding Sites; Cloning, Molecular; DNA; DNA Mutational Analysis; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression Regulation; HeLa Cells; Humans; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Serum Response Factor; Tetradecanoylphorbol Acetate | 1992 |
Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D.
Topics: Diglycerides; Enzyme Activation; Epidermal Growth Factor; Glycerophospholipids; HeLa Cells; Humans; Phosphatidic Acids; Phosphatidylinositols; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Stable induction of c-jun mRNA expression in normal human keratinocytes by agents that induce predifferentiation growth arrest.
Topics: Cell Differentiation; Cell Division; Cell Nucleus; Epidermal Growth Factor; Gene Expression Regulation; Genes, jun; Humans; Insulin; Interphase; Keratinocytes; Kinetics; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Razoxane; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor beta | 1992 |
In vitro secretion of transforming growth factor alpha (TGF-alpha): a comparison of the A431 cell line with three human oesophageal squamous cell carcinoma lines.
Topics: Carcinoma, Squamous Cell; Epidermal Growth Factor; ErbB Receptors; Esophageal Neoplasms; Humans; In Vitro Techniques; Secretory Rate; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
[Sulfolipids and glycolipid sulfotransferases in a human renal cell carcinoma cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Renal Cell; Epidermal Growth Factor; Humans; Isoquinolines; Kidney Neoplasms; Lipid Metabolism; Lipids; Piperazines; Protein Kinase C; Staurosporine; Sulfotransferases; Sulfurtransferases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The regulation of prostaglandin biosynthesis in cells derived from human gestational tissues: effects of fetal calf serum.
Topics: Amnion; Arachidonic Acid; Chorion; Culture Media; Decidua; Dinoprostone; Epidermal Growth Factor; Extraembryonic Membranes; Female; Humans; In Vitro Techniques; Interleukin-1; Ionomycin; Pregnancy; Tetradecanoylphorbol Acetate | 1992 |
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Aorta, Thoracic; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA; Epidermal Growth Factor; Female; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Lung; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate | 1992 |
Epigenetic activation of Gi-2 protein, the product of a putative protooncogene, mediates tumor promotion in vitro.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Female; GTP-Binding Proteins; Mice; Molecular Sequence Data; Mutation; Ovarian Neoplasms; Pertussis Toxin; Phenotype; Phospholipases A; Phospholipases A2; Proto-Oncogene Proteins; Rats; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Virulence Factors, Bordetella | 1992 |
Thrombin, epidermal growth factor, and phorbol myristate acetate stimulate tubulin polymerization in quiescent cells: a potential link to mitogenesis.
Topics: Animals; Binding Sites, Antibody; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Mice; Microtubules; Mitosis; Tetradecanoylphorbol Acetate; Thrombin; Tubulin | 1992 |
The role of C-Fos in growth factor regulation of stromelysin/transin gene expression.
Topics: 3T3 Cells; Animals; Base Sequence; Binding Sites; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; HeLa Cells; Humans; Matrix Metalloproteinase 3; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1992 |
Effects of epidermal growth factor, phorbol ester, and retinoic acid on hormone synthesis and morphology in porcine thyroid follicles cultured in collagen gel.
Topics: Animals; Cells, Cultured; Collagen; Culture Media; Epidermal Growth Factor; Epithelium; Intercellular Junctions; Microscopy, Electron; Sodium Iodide; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyroid Hormones; Thyroxine; Tretinoin; Triiodothyronine | 1992 |
Growth control by epidermal growth factor and transforming growth factor-alpha in human lung squamous carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Cell Line; Culture Media; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Lung Neoplasms; Protein Precursors; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1992 |
Effects of inorganic iodide, epidermal growth factor and phorbol ester on hormone synthesis by porcine thyroid follicles cultured in suspension.
Topics: Animals; Culture Media; Culture Techniques; Epidermal Growth Factor; Sodium Iodide; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyroid Hormones; Thyrotropin; Thyroxine; Triiodothyronine | 1992 |
Effects of epidermal growth factor on glycolysis in A431 cells.
Topics: Calcium; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; Fructosediphosphates; Glycolysis; Humans; Phosphofructokinase-1; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethylnitrosamine; DNA Replication; Epidermal Growth Factor; Female; Kinetics; Liver; Liver Neoplasms; Maternal-Fetal Exchange; Mutagenesis; Phenobarbital; Poly(ADP-ribose) Polymerases; Precancerous Conditions; Pregnancy; Rats; Rats, Inbred Strains; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic | 1992 |
Differential c-jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Gene Expression; Genes, fos; Genes, jun; In Vitro Techniques; Mice; Neoplasm Transplantation; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tetradecanoylphorbol Acetate | 1992 |
Differential regulation of thyrotropin receptor and thyroglobulin mRNA accumulation at the cellular level: an in situ hybridization study.
Topics: Animals; Autoradiography; Cell Differentiation; Dogs; Epidermal Growth Factor; Gene Expression Regulation; Nucleic Acid Hybridization; Receptors, Thyrotropin; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroglobulin; Thyroid Gland; Thyrotropin | 1992 |
Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.
Topics: 3T3 Cells; Alkaloids; Animals; Autoradiography; Down-Regulation; Epidermal Growth Factor; Insulin; Mice; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C-independent activation of c-jun and c-fos transcription by epidermal growth factor.
Topics: 3T3 Cells; Animals; Calcium; Cell Line; Epidermal Growth Factor; Mice; Precipitin Tests; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1992 |
Kinetics of binding, endocytosis, and recycling of EGF receptor mutants.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cell Line; DNA; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Mathematics; Mice; Mutagenesis, Site-Directed; Protein Binding; Tetradecanoylphorbol Acetate; Threonine; Transfection; Up-Regulation | 1992 |
Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells.
Topics: Base Sequence; Cells, Cultured; Cloning, Molecular; DNA; Endothelium, Vascular; Epidermal Growth Factor; Gene Library; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Interferon-gamma; Interleukin-1; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins | 1992 |
Protein kinase C activation during corneal endothelial wound repair.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Movement; Cells, Cultured; Endothelium, Corneal; Enzyme Activation; Epidermal Growth Factor; Fluorescent Antibody Technique; Fluorescent Dyes; Isoquinolines; Male; Phalloidine; Piperazines; Protein Kinase C; Rabbits; Rhodamines; Sphingosine; Tetradecanoylphorbol Acetate; Wound Healing | 1992 |
Lead perturbs epidermal growth factor (EGF) modulation of intracellular calcium metabolism and collagen synthesis in clonal rat osteoblastic (ROS 17/2.8) cells.
Topics: Animals; Calcium; Cell Compartmentation; Clone Cells; Collagen; Drug Interactions; Epidermal Growth Factor; Homeostasis; Kinetics; Lead; Models, Biological; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1992 |
Identification of a novel enhancer element mediating calcium-dependent induction of gene expression in response to either epidermal growth factor or activation of protein kinase C.
Topics: Animals; Base Sequence; Calcium; Defective Viruses; DNA Mutational Analysis; DNA-Binding Proteins; DNA, Viral; Enhancer Elements, Genetic; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Viral; In Vitro Techniques; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinase C; Rats; Repetitive Sequences, Nucleic Acid; Retroviridae; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1992 |
Parathyroid hormone-like peptide shares features with members of the early response gene family: rapid induction by serum, growth factors, and cycloheximide.
Topics: Animals; Animals, Newborn; Calcitriol; Cell Line; Culture Media; Cycloheximide; Dactinomycin; Dexamethasone; Epidermal Growth Factor; Gene Expression; Growth Substances; Keratinocytes; Multigene Family; Parathyroid Hormone-Related Protein; Proteins; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor beta; Tubulin | 1992 |
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Regulation of S6 kinase activity in renal proximal tubule.
Topics: Angiotensin II; Animals; Cells, Cultured; Epidermal Growth Factor; Hypertrophy; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Nephrectomy; Phosphorylation; Protein Biosynthesis; Protein Kinases; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate | 1992 |
Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis.
Topics: 3T3 Cells; Animals; Bombesin; Catalysis; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Glycerophospholipids; Indoles; Inositol Phosphates; Mice; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Differential regulation of protooncogenes c-jun and jun D expressions by protein tyrosine kinase, protein kinase C, and cyclic-AMP mitogenic pathways in dog primary thyrocytes: TSH and cyclic-AMP induce proliferation but downregulate C-jun expression.
Topics: Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Epidermal Growth Factor; Gene Expression Regulation; Kinetics; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Transcription Factors | 1991 |
Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethers, Cyclic; Humans; In Vitro Techniques; Okadaic Acid; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases | 1991 |
Regulation of the transmodulated epidermal growth factor receptor by cholera toxin and the protein phosphatase inhibitor okadaic acid.
Topics: Animals; Cells, Cultured; Cholera Toxin; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Ethers, Cyclic; Kinetics; Okadaic Acid; Phosphoprotein Phosphatases; Rats; Tetradecanoylphorbol Acetate | 1991 |
Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors.
Topics: Animals; Blotting, Northern; Bucladesine; Cell Line; Cells, Cultured; Cycloheximide; Epidermal Growth Factor; Fibroblast Growth Factor 5; Fibroblast Growth Factors; Fibroblasts; Gene Expression Regulation; Growth Substances; Humans; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Mas; RNA, Messenger; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Transformation, Genetic; Transforming Growth Factor alpha | 1991 |
Epidermal growth factor elevates intracellular pH in chicken granulosa cells by activating protein kinase C.
Topics: Animals; Calcium; Carrier Proteins; Chickens; Diglycerides; Drug Interactions; Enzyme Activation; Epidermal Growth Factor; Female; Granulosa Cells; Hydrogen-Ion Concentration; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1991 |
Regulation of human tissue-type plasminogen activator gene transcription by epidermal growth factor and 3',5'-cyclic adenosine monophosphate.
Topics: Blotting, Northern; Cells, Cultured; Cyclic AMP; Endothelium; Epidermal Growth Factor; Gene Expression Regulation; HeLa Cells; Humans; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Transcription, Genetic | 1991 |
Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro.
Topics: Alkaloids; Animals; Carcinogenicity Tests; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Induction; Epidermal Growth Factor; Keratinocytes; Mice; Mice, Inbred BALB C; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; RNA, Messenger; Skin Neoplasms; Staurosporine; Tetradecanoylphorbol Acetate; Transglutaminases; Tumor Cells, Cultured | 1991 |
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Topics: Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gingiva; Humans; Interleukin-1; Kinetics; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Growth factor activity of endothelin on vascular smooth muscle.
Topics: Animals; Aorta; Benzofurans; Calcium; Cell Division; Cells, Cultured; DNA Replication; Endothelins; Endothelium, Vascular; Epidermal Growth Factor; Fluorescent Dyes; Fura-2; Kinetics; Muscle, Smooth, Vascular; Peptides; Pertussis Toxin; Rats; Rats, Inbred SHR; RNA; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins.
Topics: Animals; Bombesin; Cell Line; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Mice; Mitosis; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1990 |
Transient epidermal growth factor (EGF)-dependent suppression of EGF receptor autophosphorylation during internalization.
Topics: Angiotensin II; Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelium; ErbB Receptors; Kinetics; Liver; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Glycerides; Humans; Kinetics; Peptide Mapping; Phosphopeptides; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Differential phosphorylation of myelin-associated glycoprotein isoforms in cell culture.
Topics: Animals; Bucladesine; Cell Line; Cell Transformation, Neoplastic; Cyclic AMP; Epidermal Growth Factor; Insulin; Insulin-Like Growth Factor I; Mice; Myelin Proteins; Myelin-Associated Glycoprotein; Phosphorylation; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Guanosine Diphosphate; Guanylyl Imidodiphosphate; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Liver; Mice; Phosphotyrosine; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thionucleotides; Tyrosine | 1990 |
In vitro modulation and relationship between N-myc and HLA class I RNA steady-state levels in human neuroblastoma cells.
Topics: Blotting, Northern; Bucladesine; Epidermal Growth Factor; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, myc; Histocompatibility Antigens Class I; Humans; In Vitro Techniques; Interferon-gamma; Nerve Growth Factors; Neuroblastoma; Oncogene Protein p55(v-myc); RNA; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1990 |
Protein kinase C and limited substrates for tyrosine kinase are involved in epidermal growth factor (EGF)-dependent growth of a human squamous cell carcinoma cell variant.
Topics: Amino Acids; Cell Division; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Regulation of insulin-like growth factor-binding protein messenger ribonucleic acid levels in sheep thyroid cells.
Topics: Actins; Animals; Biological Availability; Blotting, Western; Carrier Proteins; Cells, Cultured; Culture Media; DNA Probes; Epidermal Growth Factor; Gene Expression Regulation; Humans; Immunosorbent Techniques; Insulin-Like Growth Factor Binding Proteins; Molecular Weight; Nucleic Acid Hybridization; RNA, Messenger; Sheep; Species Specificity; Tetradecanoylphorbol Acetate; Thyroid Gland | 1991 |
The effect of fetal calf serum on growth arrest caused by activators of protein kinase C.
Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Blood; Bryostatins; Cattle; Cell Division; Culture Media; DNA Replication; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Epidermal growth factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss 3T3 cells. Regulation through a protein kinase C-independent pathway.
Topics: Animals; Blotting, Northern; Blotting, Western; Cytoskeletal Proteins; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Integrins; Mice; Protein Kinase C; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Vinculin | 1991 |
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cell Line; Colforsin; DNA Probes; Enzyme Induction; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mice; Molecular Sequence Data; Oligonucleotide Probes; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Conformation; RNA; RNA, Messenger; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate | 1991 |
Epidermal growth factor, a modulator of luteal adenylate cyclase. Characterization of epidermal growth factor receptors and its interaction with adenylate cyclase system in bovine luteal cell membrane.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cattle; Cell Membrane; Colforsin; Corpus Luteum; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; In Vitro Techniques; Molecular Weight; Phosphorylation; Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine | 1991 |
Activation of signal transduction pathways protects quiescent Balb/c-3T3 fibroblasts against death due to serum deprivation.
Topics: 2-Aminopurine; Alkaloids; Animals; Cell Division; Cell Survival; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Insulin; Insulin-Like Growth Factor I; Mice; Mice, Inbred BALB C; Neutral Red; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; RNA; S Phase; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Second messenger pathways mediating chicken luteinizing hormone secretion from dispersed pituitary cells.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Chickens; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Male; Pituitary Gland; Protein Kinase C; Second Messenger Systems; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transforming Growth Factor alpha | 1991 |
Growth regulation of serum-free cultures of epithelial cells from normal human buccal mucosa.
Topics: Animals; Blood; Calcium; Cattle; Cell Division; Cholera Toxin; Culture Media; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; In Vitro Techniques; Keratins; Microscopy, Electron, Scanning; Mouth Mucosa; Pituitary Hormones; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tretinoin | 1991 |
Identification of protein-binding sequences mediating constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced VL30 transcription in cultured mouse and human keratinocytes.
Topics: Animals; Autoradiography; Base Sequence; Blotting, Northern; Cells, Cultured; Chloramphenicol O-Acetyltransferase; DNA; Epidermal Growth Factor; Gene Expression Regulation; Genes, Viral; Humans; Keratinocytes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Restriction Mapping; RNA; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Cytotactin binding: inhibition of stimulated proliferation and intracellular alkalinization in fibroblasts.
Topics: 3T3 Cells; Animals; Brain; Cell Adhesion Molecules, Neuronal; Cell Division; Chick Embryo; DNA Replication; Epidermal Growth Factor; Extracellular Matrix; Extracellular Matrix Proteins; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Growth Substances; Hydrogen-Ion Concentration; Kinetics; Mice; Platelet-Derived Growth Factor; Tenascin; Tetradecanoylphorbol Acetate; Thymidine | 1991 |
Thyrotropin inhibits while insulin, epidermal growth factor and tetradecanoyl phorbol acetate stimulate insulin-like growth factor binding protein secretion from sheep thyroid cells.
Topics: Animals; Carrier Proteins; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Drug Synergism; Epidermal Growth Factor; Growth Inhibitors; Insulin; Insulin-Like Growth Factor Binding Proteins; Iodides; Molecular Weight; Rats; Sheep; Somatomedins; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1991 |
Differential regulation of gene expression by estrogen in estrogen growth-independent and -dependent MCF-7 human breast cancer cell sublines.
Topics: 1-Methyl-3-isobutylxanthine; Breast Neoplasms; Cell Line, Transformed; Clone Cells; Down-Regulation; Epidermal Growth Factor; Estradiol; Female; Gene Expression Regulation; Humans; Polyunsaturated Alkamides; Receptors, Cell Surface; Receptors, Estradiol; Receptors, Progesterone; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1991 |
Transforming growth factor-beta (TGF beta) inhibits TGF alpha expression in bovine anterior pituitary-derived cells.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Pituitary Gland, Anterior; Poly A; RNA; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Transforming Growth Factor beta | 1991 |
Thyroid autocrine factors: regulation of secretion of insulin-like growth factor binding proteins from sheep thyroid cells by autocrine basic fibroblast growth factor.
Topics: Animals; Carrier Proteins; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factor 2; Insulin-Like Growth Factor Binding Proteins; RNA, Messenger; Sheep; Tetradecanoylphorbol Acetate; Thyroid Gland | 1991 |
Serum-free culture of fractionated bovine bronchial epithelial cells.
Topics: Animals; Bronchi; Calcimycin; Calcium; Cattle; Cell Division; Cell Separation; Centrifugation, Density Gradient; Culture Media, Serum-Free; Culture Techniques; Epidermal Growth Factor; Epithelial Cells; Epithelium; Kinetics; Mitotic Index; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1992 |
Highly purified human alpha-thrombin promotes morphological transformation of BALB/c 3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; Mice; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Regulation of surface expression of high-affinity receptors for epidermal growth factor (EGF) in hepatocytes by hormones, differentiating agents, and phorbol ester.
Topics: Animals; Butyrates; Butyric Acid; Dexamethasone; Dimethyl Sulfoxide; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Liver; Rats; Tetradecanoylphorbol Acetate; Up-Regulation | 1992 |
EGF-induced jun B-expression in transfected P19 embryonal carcinoma cells expressing EGF-receptors is dependent on Jun D.
Topics: Blotting, Northern; Calcimycin; Chloramphenicol O-Acetyltransferase; Drug Synergism; Embryonal Carcinoma Stem Cells; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, jun; Neoplastic Stem Cells; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1992 |
Differential inhibition of epidermal growth factor binding by photoactivated psoralens and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in cells overexpressing protein kinase C.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; Furocoumarins; Gene Expression Regulation, Enzymologic; Protein Kinase C; Rats; Temperature; Tetradecanoylphorbol Acetate | 1991 |
Na+/K+/Cl- cotransport is stimulated by a Ca(++)-calmodulin-mediated pathway in BALB/c 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Bumetanide; Calcium; Calcium Channel Blockers; Calmodulin; Carrier Proteins; Chlorides; Chlorpromazine; Epidermal Growth Factor; Gallic Acid; Growth Substances; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Kinetics; Mice; Mice, Inbred BALB C; Potassium; Protein Kinase C; Rubidium; Sodium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate; Trifluoperazine | 1991 |
Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Bradykinin; Cell Adhesion Molecules, Neuronal; Cell Division; Cell Line; Diploidy; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblasts; Membrane Glycoproteins; Mice; Molecular Sequence Data; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1991 |
A cell cycle ts mutant, tsJT16, is defective in p70 synthesis through protein kinase C-dependent and -independent pathways.
Topics: Animals; Cell Cycle; Cell Line; Epidermal Growth Factor; Fibroblasts; G1 Phase; Gene Expression Regulation; Genes, fos; Genes, myc; Mutation; Nuclear Proteins; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Rats; Resting Phase, Cell Cycle; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Amplification of prostaglandin I2 production by thapsigargin.
Topics: Animals; Binding Sites; Cell Line; Epidermal Growth Factor; Epoprostenol; Fibroblast Growth Factor 2; Heparin; Interleukin-1; Liver; Lyngbya Toxins; Rats; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha | 1991 |
Epidermal growth factor and 12-tetradecanoyl phorbol 13-acetate induction of urokinase in A431 cells.
Topics: Chromogenic Compounds; Electrophoresis, Gel, Two-Dimensional; Enzyme Induction; Epidermal Growth Factor; Humans; Oligopeptides; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Urokinase-Type Plasminogen Activator | 1991 |
Regulation of the expression of mitogen-regulated protein (MRP; proliferin) and cathepsin L in cultured cells and in the murine placenta.
Topics: 3T3 Cells; Animals; Cathepsin L; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression Regulation; Gestational Age; Glycoproteins; Growth Substances; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Mice; Placenta; Placentation; Prolactin; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1991 |
Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.
Topics: Animals; Calcium; Cell Line; Epidermal Growth Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Interleukins; Ionomycin; Lymphocytes; Mice; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-2; Receptors, Interleukin-3; Receptors, Interleukin-4; Receptors, Mitogen; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Ethanol causes desensitization of receptor-mediated phospholipase C activation in isolated hepatocytes.
Topics: Angiotensin II; Animals; Calcium; Enzyme Activation; Epidermal Growth Factor; Ethanol; Glucagon; Liver; Male; Phenylephrine; Phosphatidylinositol Phosphates; Phosphatidylinositols; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Vasopressins | 1991 |
Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Base Sequence; Bucladesine; Cloning, Molecular; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression; Immediate-Early Proteins; Interleukin-6; Membrane Potentials; Molecular Sequence Data; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Pentylenetetrazole; Pheochromocytoma; Potassium Chloride; Rats; Restriction Mapping; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Suppressor Proteins | 1991 |
A negative feedback loop attenuates EGF-induced morphological changes.
Topics: Alanine; Animals; Cell Line; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Feedback; Humans; Microscopy, Electron, Scanning; Mutation; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Differential regulation of the 55 and 44 kDa forms of secreted phosphoprotein 1 (SPP-1, osteopontin) in normal and transformed rat bone cells by osteotropic hormones, growth factors and a tumor promoter.
Topics: Animals; Calcitriol; Cell Line; Cell Line, Transformed; Cells, Cultured; Concanavalin A; Epidermal Growth Factor; Growth Substances; Nucleic Acid Hybridization; Osteopontin; Osteosarcoma; Parathyroid Hormone; Platelet-Derived Growth Factor; Precipitin Tests; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor beta; Tretinoin | 1991 |
A proposed common mechanism by which phorbol esters and epidermal growth factor delay the progression from G2 phase to mitosis of HeLa cells through phospholipid metabolites.
Topics: Arachidonic Acids; Diglycerides; Epidermal Growth Factor; G2 Phase; HeLa Cells; Humans; Kinetics; Mitosis; Phosphatidic Acids; Phospholipids; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Elevation of glucose transporter, c-myc, and transin RNA levels by Ha-rasT24 is independent of its effect on the cell cycle.
Topics: Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA Replication; Epidermal Growth Factor; Fibroblasts; G1 Phase; Gene Expression; Genes, myc; Genes, ras; Kinetics; Matrix Metalloproteinase 3; Metalloendopeptidases; Monosaccharide Transport Proteins; Neoplasm Proteins; Rats; RNA, Messenger; S Phase; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1991 |
Regulation of transforming growth factor-alpha mRNA expression in T3M4 human pancreatic carcinoma cells.
Topics: Dactinomycin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Nucleic Acid Hybridization; Pancreatic Neoplasms; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1991 |
Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Blotting, Northern; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Glomerular Mesangium; Indomethacin; Ketoconazole; Male; Masoprocol; Pyridines; Rats; Rats, Inbred WKY; RNA, Messenger; Tetradecanoylphorbol Acetate | 1991 |
Regulation of hepatic energy metabolism by epidermal growth factor.
Topics: Animals; Calcium; Carbon Dioxide; Energy Metabolism; Epidermal Growth Factor; Gluconeogenesis; In Vitro Techniques; Ketoglutarate Dehydrogenase Complex; Liver; Male; Pertussis Toxin; Protein Kinase C; Pyruvate Kinase; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; DNA Replication; Epidermal Growth Factor; Kinetics; Lactones; Macrolides; Pituitary Neoplasms; Protein Kinase C; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine; Thyrotropin-Releasing Hormone | 1991 |
Induction of glutathione S-transferase P-form in primary cultured rat hepatocytes by epidermal growth factor and insulin.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Induction; Epidermal Growth Factor; Gene Expression; Glutathione Transferase; Insulin; Isoenzymes; Liver; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta | 1991 |
Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes.
Topics: Cell Nucleus; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Genes, jun; Gravitation; Humans; Protein Kinase C; Signal Transduction; Space Flight; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Acute regulation of the epidermal growth factor receptor in response to nerve growth factor.
Topics: Animals; Cystine; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factors; Iodine Radioisotopes; Kinetics; Methionine; Molecular Weight; Nerve Growth Factors; PC12 Cells; Radioligand Assay; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Transcriptional regulation of the human transforming growth factor-alpha gene.
Topics: Base Sequence; Breast Neoplasms; Dexamethasone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; In Vitro Techniques; Luciferases; Molecular Sequence Data; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Transforming Growth Factor alpha; Tretinoin; Triiodothyronine; Tumor Cells, Cultured | 1991 |
Effects of transforming growth factor beta on the anchorage-independent growth of murine epithelial JB6 cells.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Clone Cells; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Epithelium; Mice; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tretinoin | 1991 |
Covalent linkage between nucleotides and platelet-derived endothelial cell growth factor.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Colforsin; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Humans; Molecular Sequence Data; Nucleotides; Phosphorylation; Precipitin Tests; Tetradecanoylphorbol Acetate; Thymidine Phosphorylase; Tumor Cells, Cultured | 1991 |
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; HeLa Cells; Humans; Insulin; Kinetics; Mice; Mitogens; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Structure and inducible regulation of the human c-erb B2/neu promoter.
Topics: Base Sequence; Bucladesine; Cloning, Molecular; Deoxyribonucleases, Type II Site-Specific; Epidermal Growth Factor; Gene Expression Regulation; HeLa Cells; Humans; Luciferases; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Proteins; Receptor, ErbB-2; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transfection; Tretinoin | 1990 |
Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis.
Topics: Animals; Biological Transport; Coated Pits, Cell-Membrane; Colchicine; Cytochalasin D; Endocytosis; Endosomes; Epidermal Growth Factor; Fluorescent Dyes; Isoquinolines; Kinetics; Membrane Fluidity; Microscopy, Electron; Ricin; Sucrose; Tetradecanoylphorbol Acetate; Transferrin; Vero Cells | 1990 |
Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cross-Linking Reagents; DNA Replication; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression; Kinetics; Macromolecular Substances; Mice; Molecular Weight; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogenes; Receptor, ErbB-2; Tetradecanoylphorbol Acetate; Thymidine | 1990 |
Three classes of epidermal growth factor receptors on HeLa cells.
Topics: Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Kinetics; Tetradecanoylphorbol Acetate | 1991 |
Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.
Topics: Animals; Cell Line; Epidermal Growth Factor; Genetic Variation; Immunoblotting; Insulin; Kinetics; Mice; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1991 |
The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cloning, Molecular; DNA; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression; Immediate-Early Proteins; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Multigene Family; Nerve Growth Factors; Oligonucleotides; Proteins; Tetradecanoylphorbol Acetate; Tristetraprolin | 1991 |
Signalling and superinduction.
Topics: Animals; Cell Line; Epidermal Growth Factor; Mice; Protein Synthesis Inhibitors; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Evidence for autocrine/paracrine growth stimulation by transforming growth factor-alpha during the process of skin tumor promotion.
Topics: Animals; Anthracenes; Binding, Competitive; Carcinogens; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Mice; Protein Kinase C; RNA, Messenger; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1991 |
Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor.
Topics: Animals; Chorionic Gonadotropin; Down-Regulation; Epidermal Growth Factor; Humans; Leydig Cells; Male; Receptors, LH; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1991 |
Phorbol ester TPA inhibits the stimulation of bumetanide-sensitive Na+/K+/Cl- transporter by different mitogens in quiescent BALB/c 3T3 mouse fibroblasts.
Topics: Animals; Bumetanide; Carrier Proteins; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Mice; Mice, Inbred BALB C; Mitogens; Platelet-Derived Growth Factor; Rubidium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate; Thrombin; Transforming Growth Factor alpha | 1991 |
Dual effect of protein kinase C on the induction of DNA synthesis by colcemid in G0-arrested human diploid fibroblasts.
Topics: Alkaloids; Blotting, Northern; Cell Line; Colchicine; Demecolcine; DNA; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Protein Kinase C; Resting Phase, Cell Cycle; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity.
Topics: Animals; Cells, Cultured; Cycloheximide; Enzyme Activation; Epidermal Growth Factor; Glucosephosphate Dehydrogenase; Guanine Nucleotides; Inositol Phosphates; Ionomycin; Kidney Tubules, Proximal; Male; Pentose Phosphate Pathway; Pertussis Toxin; Phosphogluconate Dehydrogenase; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Streptolysins; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Two classes of continuous cell lines established from Syrian hamster 9 day gestation embryos: preneoplastic cells and progenitor cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cricetinae; Embryo, Mammalian; Epidermal Growth Factor; Gestational Age; Mesocricetus; Neoplasms, Experimental; Phorbol Esters; Ploidies; Stem Cells; Tetradecanoylphorbol Acetate | 1990 |
Zinc increases EGF-stimulated DNA synthesis in primary mouse hepatocytes. Studies in tumor promoter-treated cell cultures.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; Chlorides; Culture Media; DNA; Drug Interactions; Epidermal Growth Factor; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Polychlorinated Biphenyls; Tetradecanoylphorbol Acetate; Zinc; Zinc Compounds | 1990 |
Hormonally inducible phosphorylation of a nuclear pool of ribosomal protein S6.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Fractionation; Cell Line; Cell Nucleolus; Cell Nucleus; Epidermal Growth Factor; Liver; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphorylation; Pituitary Gland; Rats; Ribosomal Protein S6; Ribosomal Proteins; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Trypsin | 1990 |
2-Aminopurine abolishes EGF- and TPA-stimulated pp33 phosphorylation and c-fos induction without affecting the activation of protein kinase C.
Topics: 2-Aminopurine; Adenine; Adenosine Triphosphate; Animals; Base Sequence; Blotting, Northern; Cell Membrane; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Membrane Proteins; Mice; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotide Probes; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors | 1990 |
Epidermal growth factor enhances glomerular mesangial cell soluble phospholipase A2 activity.
Topics: Animals; Arginine Vasopressin; Calcimycin; Cells, Cultured; Chromatography, Ion Exchange; Cytosol; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Glomerular Mesangium; Inositol; Inositol Phosphates; Kinetics; NAD; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Inositol Phosphates; Kinetics; Mice; Mutation; Peptide Mapping; Phosphopeptides; Phosphorylation; Plasmids; Tetradecanoylphorbol Acetate; Threonine; Transfection; Type C Phospholipases | 1990 |
Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.
Topics: Animals; Base Sequence; Cell Differentiation; Cell Division; Cloning, Molecular; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression Regulation; Immunologic Techniques; Metalloproteins; Mice; Molecular Sequence Data; Nerve Growth Factors; Nuclear Proteins; Phosphoproteins; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Transcription Factors; Zinc | 1990 |
Modulation of RNA expression by intracellular calcium. Existence of a threshold calcium concentration for induction of VL30 RNA by epidermal growth factor, endothelin, and protein kinase C.
Topics: Animals; Benzofurans; Calcimycin; Calcium; Carrier Proteins; Cell Line; Egtazic Acid; Endothelins; Endothelium, Vascular; Epidermal Growth Factor; Fluorescent Dyes; Fura-2; Inositol Phosphates; Peptides; Peptidylprolyl Isomerase; Protein Kinase C; Rats; Retroviridae; RNA, Viral; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1990 |
Mechanism of 12-O-tetradecanoylphorbol-13-acetate enhanced metabolism of arachidonic acid in dog urothelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprostone; Dogs; Eicosanoids; Epidermal Growth Factor; Epithelium; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Tritium; Urinary Bladder | 1990 |
A Swiss 3T3 variant cell line resistant to the effects of tumor promoters cannot be transformed by src.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Deoxyglucose; DNA Probes; DNA Replication; Drug Resistance; Epidermal Growth Factor; Mice; Oncogene Protein pp60(v-src); Oncogenes; Plasmids; Retroviridae; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Mevalonate deprivation alters the induction of fos and myc by growth factors.
Topics: Blotting, Northern; Cells, Cultured; Dactinomycin; Epidermal Growth Factor; Gene Expression; Growth Substances; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Activation of the serum-response and TPA-response elements by expression of the v-abl protein: comparison of the mode of action of the v-abl protein with those of protein kinase C, cyclic AMP-dependent protein kinase, and the activated c-raf protein.
Topics: Blood Physiological Phenomena; Chloramphenicol O-Acetyltransferase; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation; Luciferases; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Tetradecanoylphorbol Acetate; Transfection; Viral Proteins | 1990 |
Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester.
Topics: Animals; Animals, Newborn; Base Sequence; Cell Line; Cells, Cultured; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Genes; Keratinocytes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; Plasminogen Activators; Promoter Regions, Genetic; Restriction Mapping; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Urokinase-Type Plasminogen Activator | 1990 |
Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.
Topics: Animals; Bombesin; Bradykinin; Cell Line; Epidermal Growth Factor; Growth Substances; GTP-Binding Proteins; Kinetics; Pertussis Toxin; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Vanadates; Virulence Factors, Bordetella | 1990 |
Endothelin-1 stimulates DNA synthesis and anchorage-independent growth of Rat-1 fibroblasts through a protein kinase C-dependent mechanism.
Topics: Animals; Cell Division; Cell Line; Diglycerides; DNA Replication; DNA-Binding Proteins; Endothelins; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Histones; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Second Messenger Systems; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1990 |
[Effect of pulsed electromagnetic fields (PEMF) on osteoblast-like cells. Alterations of intracellular Ca2+].
Topics: Animals; Bone and Bones; Bone Remodeling; Calcium; Cell Membrane; Cells, Cultured; DNA; Electromagnetic Fields; Epidermal Growth Factor; ErbB Receptors; Membrane Potentials; Osteoblasts; Rats; Second Messenger Systems; Tetradecanoylphorbol Acetate | 1990 |
[Effect of pulsed electromagnetic fields (PEMF) on human periodontal ligament in vitro. Alterations of intracellular Ca2+].
Topics: Bone Remodeling; Calcium; Cells, Cultured; Electromagnetic Fields; Epidermal Growth Factor; Fibroblasts; Humans; Periodontal Ligament; Physical Stimulation; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate.
Topics: Adenylyl Cyclases; Animals; Cell Survival; Cycloheximide; Embryo, Mammalian; Epidermal Growth Factor; ErbB Receptors; Mice; Nerve Growth Factors; Neurons; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Protein Kinase C; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Tretinoin; Vanadates | 1990 |
Epidermal growth factor and cyclic AMP stimulate Na+/H+ exchange in isolated rat hepatocytes.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cytoplasm; Energy Transfer; Enzyme Activation; Epidermal Growth Factor; Liver; Proton-Translocating ATPases; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate | 1990 |
The epidermal growth factor receptor is coupled to a phospholipase A2-specific pertussis toxin-inhibitable guanine nucleotide-binding regulatory protein in cultured rat inner medullary collecting tubule cells.
Topics: Adenosine Diphosphate Ribose; Aluminum; Aluminum Compounds; Animals; Calcium; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Kinetics; Pertussis Toxin; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Stimulation of progesterone receptors by phorbol ester and cyclic AMP in fetal uterine cells in culture.
Topics: Animals; Bucladesine; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Guinea Pigs; Kinetics; Protein Kinase C; Receptors, Progesterone; Tamoxifen; Tetradecanoylphorbol Acetate; Uterus | 1990 |
The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation.
Topics: Animals; Arachidonic Acids; Cell Line; Diglycerides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Phospholipases; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1990 |
Regulation of protooncogenes c-fos and c-myc expressions by protein tyrosine kinase, protein kinase C, and cyclic AMP mitogenic pathways in dog primary thyrocytes: a positive and negative control by cyclic AMP on c-myc expression.
Topics: Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1990 |
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
Topics: Amino Acids; Animals; Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Mice; Phosphates; Phosphopeptides; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thymidine; Transfection; Trypsin | 1990 |
Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Inositol Phosphates; Kinetics; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate | 1990 |
Reduced tyrosine phosphorylation and nonresponsiveness to EGF-mediated cytotoxicity in EGF receptor-hyperproducing UCVA-1 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Peptide Mapping; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1990 |
Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene.
Topics: Base Composition; Base Sequence; Cell Nucleus; Chromosome Deletion; Codon; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes; HeLa Cells; Humans; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Promoter Regions, Genetic; TATA Box; Tetradecanoylphorbol Acetate | 1990 |
Second messenger modulation of epidermal growth factor receptor function does not occur at the level of receptor dimerization.
Topics: Animals; Calcium; Cell Line; Cell Membrane Permeability; Cross-Linking Reagents; Cyclic AMP; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Glycosylation; Humans; Hydrogen-Ion Concentration; Immunoblotting; Ionomycin; Macromolecular Substances; Membrane Potentials; Mice; Neuraminidase; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Saline Solution, Hypertonic; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation.
Topics: Alanine; Animals; Cell Line; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Ligands; Mice; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Threonine; Transfection | 1990 |
Epidermal growth factor and 12-O-tetradecanoylphorbol 13-acetate stimulate lactate production and the pentose phosphate pathway in freshly isolated rat hepatocytes.
Topics: Animals; Bucladesine; Cells, Cultured; Epidermal Growth Factor; Glycolysis; Insulin; Kinetics; Lactates; Liver; Male; Pentose Phosphate Pathway; Phenylephrine; Pyruvates; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Potentiation of oncogenic N-ras-induced neurite outgrowth and ornithine decarboxylase activity by phorbol dibutyrate and protein kinase inhibitor H-8.
Topics: Animals; Cell Differentiation; Cell Transformation, Neoplastic; Colforsin; Dexamethasone; Epidermal Growth Factor; Isoquinolines; Nerve Growth Factors; Neurons; Oncogene Protein p21(ras); Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1990 |
Regulation of pancreatic duct epithelial growth in vitro.
Topics: Animals; Bombesin; Carbachol; Cell Division; Cells, Cultured; Ceruletide; Epidermal Growth Factor; Epithelial Cells; Epithelium; Guinea Pigs; Kinetics; Microscopy, Phase-Contrast; Organ Culture Techniques; Pancreatic Ducts; Secretin; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1990 |
Possible contribution of protein kinase C activation to priming for DNA synthesis induced by epidermal growth factor with insulin and its inhibition by plasma membrane in primary cultured rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; DNA; DNA Replication; Enzyme Activation; Epidermal Growth Factor; Insulin; Isoquinolines; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Vasopressins | 1990 |
Two subclasses of EGF receptors in the human pancreatic cancer cell lines CAPAN-1 and MIA PaCa-2.
Topics: Cell Division; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Pancreatic Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally.
Topics: Adrenal Gland Neoplasms; Animals; Calcimycin; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Multigene Family; Nerve Growth Factors; Nuclear Receptor Subfamily 4, Group A, Member 1; Pheochromocytoma; Phosphorylation; Protein Processing, Post-Translational; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Thyroid Hormone; Tetradecanoylphorbol Acetate; Transcription Factors | 1990 |
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
Topics: Animals; Cell Division; Cell Line; DNA Replication; Epidermal Growth Factor; Glycerol; Inositol; Insulin; Kinetics; Mice; Phosphates; Phosphatidic Acids; Sphingosine; Tetradecanoylphorbol Acetate; Thymidine | 1990 |
Evidence of a role for protein kinase C in epidermal growth factor-induced prostaglandin E2 synthesis in amnion cells.
Topics: Alkaloids; Amnion; Cell Line; Dinoprostone; Down-Regulation; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Female; Humans; Pregnancy; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Role of protein kinase C in the regulation of cytosolic Ca2+ in A431 cells: separation of growth factor and bradykinin pathways.
Topics: Alkaloids; Bradykinin; Calcium; Cytosol; Down-Regulation; Epidermal Growth Factor; Humans; Ionomycin; Manganese; Protein Kinase C; Pyrimidinones; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1990 |
Characterization of epidermal growth factor receptor induction by retinoic acid in a chemically transformed rat liver cell line.
Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Cycloheximide; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Gene Expression; In Vitro Techniques; Methylnitronitrosoguanidine; Precipitin Tests; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1990 |
Transmodulation of epidermal growth factor binding by platelet-derived growth factor and 12-O-tetradecanoylphorbol-13-acetate is not sodium-dependent in Balb/c/3T3 cells.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred BALB C; Monensin; Platelet-Derived Growth Factor; Recombinant Proteins; Sodium; Tetradecanoylphorbol Acetate | 1990 |
Stimulation of porcine thyroid cell alkalinization and growth by EGF, phorbol ester, and diacylglycerol.
Topics: Amiloride; Animals; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Epidermal Growth Factor; Glycerides; Hydrogen-Ion Concentration; Kinetics; Sodium; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Trifluoperazine | 1990 |
Induction of distinct phenotypes in clonal and variant GH4 pituitary cells.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules, Neuronal; Cell Division; Cell Movement; Clone Cells; Epidermal Growth Factor; Epithelial Cells; Phenotype; Pituitary Gland; Pituitary Neoplasms; Prolactin; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Amiloride inhibits constitutive internalization and increases the surface number of epidermal growth factor receptors in intact rat hepatocytes.
Topics: Amiloride; Ammonium Chloride; Animals; Cells, Cultured; Cycloheximide; Down-Regulation; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Liver; Monensin; Puromycin; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Epidermal growth factor and phorbol ester regulate prolactin gene expression via distinct pathways.
Topics: Animals; Cell Line; Epidermal Growth Factor; Gene Expression Regulation; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1990 |
Modulation of EGF-receptors by phorbol ester in small intestinal crypt cells.
Topics: Animals; Binding, Competitive; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Intestine, Small; Kinetics; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Differential effects of phorbol ester on epidermal growth factor receptors in estrogen receptor-positive and -negative breast cancer cell lines.
Topics: Breast Neoplasms; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Cycle; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Protein Kinase C; Receptors, Drug; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Differential mechanism for the inhibition of epidermal growth factor binding to its receptor on mouse keratinocytes by anthrones and phorbol esters.
Topics: Animals; Anthracenes; Carcinogens; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Female; Keratinocytes; Kinetics; Mice; Mice, Inbred Strains; Protein Kinase C; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin E | 1990 |
Effect of TPA on ion fluxes and DNA synthesis in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Biological Transport; Cell Line; Chlorides; DNA; Epidermal Growth Factor; Ion Channels; Muscle, Smooth, Vascular; Phorbols; Potassium; Rats; Sodium; Tetradecanoylphorbol Acetate | 1985 |
Ionic signalling by growth factor receptors.
Topics: Animals; Calcium; Carrier Proteins; Cell Division; Cytosol; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Ion Channels; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1986 |
Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent.
Topics: 1-Methyl-3-isobutylxanthine; Blood Physiological Phenomena; Calcimycin; Calcium; Cholera Toxin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate | 1986 |
Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cell Line; Cholera Toxin; Chromatography, Thin Layer; Epidermal Growth Factor; Lipid Metabolism; Pertussis Toxin; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphorylation; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella | 1987 |
Stimulation of the phosphorylation of a 66,000-Da soluble tyrosine phosphoprotein by agents that activate or augment activation of human peripheral blood T lymphocytes.
Topics: Calcimycin; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lymphocyte Activation; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tyrosine; Wheat Germ Agglutinins | 1987 |
Palytoxin: an extraordinarily potent stimulator of prostaglandin production and bone resorption in cultured mouse calvariae.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Acrylamides; Animals; Bone and Bones; Bone Resorption; Cnidarian Venoms; Cyclic AMP; Dinoprostone; Epidermal Growth Factor; Growth Substances; Indomethacin; Mice; Organ Culture Techniques; Parathyroid Hormone; Peptides; Prostaglandins E; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1987 |
Modulation of stimulatory action of follicle stimulating hormone (FSH) and inhibitory action of epidermal growth factor (EGF) on aromatase activity in Sertoli cells by calcium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aromatase; Aromatase Inhibitors; Bucladesine; Calcium; Egtazic Acid; Enzyme Activation; Epidermal Growth Factor; Estradiol; Follicle Stimulating Hormone; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sertoli Cells; Tetradecanoylphorbol Acetate | 1987 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Metallothionein; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mutation; Proto-Oncogenes; Tetradecanoylphorbol Acetate | 1987 |
Immunohistochemical detection of c-myc oncogene product in human gastric carcinomas: expression in tumor cells and stromal cells.
Topics: Epidermal Growth Factor; Humans; Immunohistochemistry; Interferons; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Mammary gland morphogenesis in vitro: extracellular requirements for the formation of tubules in collagen gels by a cloned rat mammary epithelial cell line.
Topics: Animals; Cholera Toxin; Clone Cells; Collagen; Culture Media; Epidermal Growth Factor; Female; Growth Substances; Hyaluronic Acid; Hydrocortisone; Insulin; Keratins; Mammary Glands, Animal; Microscopy, Electron; Morphogenesis; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Reversible induction of anchorage independent growth from normal mouse epidermal keratinocytes, MSK-C3H-NU, in soft agar medium by 12-O-tetradecanoylphorbol-13-acetate and epidermal growth factor.
Topics: Agar; Animals; Cells, Cultured; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Keratins; Mice; Phorbol Esters; Tetradecanoylphorbol Acetate | 1988 |
Action of epidermal growth factor on acid secretion by rat isolated parietal cells.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Bucladesine; Epidermal Growth Factor; Flurbiprofen; Gastric Acid; Histamine; Imidazoles; In Vitro Techniques; Male; Parietal Cells, Gastric; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1987 |
Pharmacological regulation of morphology and mitosis in cultured rabbit corneal endothelium.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Cell Count; Culture Techniques; Endothelium, Corneal; Epidermal Growth Factor; Indomethacin; Male; Microscopy, Electron; Mitosis; Rabbits; Tetradecanoylphorbol Acetate; Toxins, Biological | 1988 |
Thyrotropin releasing hormone action in pituitary cells. Protein kinase C-mediated effects on the epidermal growth factor receptor.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Immunoassay; Molecular Weight; Phosphorylation; Phosphotyrosine; Pituitary Gland; Pituitary Neoplasms; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1988 |
Effect of pertussis toxin on the inhibition of secretory activity by prostaglandin E2, somatostatin, epidermal growth factor and 12-O-tetradecanoylphorbol 13-acetate in parietal cells from rat stomach.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Dinoprostone; Epidermal Growth Factor; GTP-Binding Proteins; Histamine; Kinetics; Male; Parietal Cells, Gastric; Pertussis Toxin; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes.
Topics: Calcium; Cell Communication; Cells, Cultured; Epidermal Growth Factor; Growth Substances; Hormones; Humans; In Vitro Techniques; Intercellular Junctions; Keratins; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate; Thymidine; Transforming Growth Factors | 1989 |
Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Topics: Alkaloids; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Phosphotyrosine; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured; Tyrosine | 1989 |
Mitogenic activity of phorbol esters and insulin-like growth factor 1 in chemically transformed mouse fibroblasts BP-A31: independent effects and differential sensitivity to inhibition by 3-isobutyl-1-methyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cell Division; Cell Transformation, Neoplastic; Colforsin; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Insulin; Insulin-Like Growth Factor I; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Somatomedins; Suramin; Tetradecanoylphorbol Acetate; Theophylline | 1989 |
Effects of platelet-derived growth factor on phosphorylation of the epidermal growth factor receptor in human skin fibroblasts.
Topics: Binding, Competitive; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
Regulation of osteosarcoma EGF receptor affinity by phorbol ester and cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Colforsin; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Humans; Iodine Radioisotopes; Osteosarcoma; Parathyroid Hormone; Tetradecanoylphorbol Acetate | 1989 |
Characterization of insulin-like growth factor-binding proteins from sheep thyroid cells.
Topics: Affinity Labels; Animals; Carrier Proteins; Cells, Cultured; Collodion; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Glycoside Hydrolases; Glycosylation; Humans; Immunosorbent Techniques; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Kinetics; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Sheep; Tetradecanoylphorbol Acetate; Thyroid Gland | 1989 |
Cell cycle position affects response of normal fibroblasts to phorbol esters.
Topics: Bisbenzimidazole; Bromodeoxyuridine; Cell Cycle; Cell Division; Cells, Cultured; DNA; Epidermal Growth Factor; Fibroblasts; Flow Cytometry; Humans; Tetradecanoylphorbol Acetate | 1988 |
Effects of EGF and PMA on the growth and proliferation of IEC-6 cells.
Topics: Animals; Cell Line; DNA; Epidermal Growth Factor; Epithelium; Intestine, Small; Protein Biosynthesis; Rats; RNA; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Ligand-induced desensitization of 125I-epidermal growth factor internalization.
Topics: Animals; Calcimycin; Calmodulin; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Hydrogen-Ion Concentration; Iodine Radioisotopes; Mice; Peptide Hydrolases; Protein Kinase C; Streptomyces griseus; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester and interferon-gamma modulation of epidermal growth factor receptors on human amniotic (WISH) cells.
Topics: Cell Compartmentation; Cell Line; Cell Survival; DNA; Epidermal Growth Factor; ErbB Receptors; Humans; Interferon-gamma; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
A novel method for measuring protein kinase C activity in a native membrane-associated state.
Topics: Animals; Bombesin; Calcium; Cell Membrane; Cytosol; Egtazic Acid; Enzyme Activation; Epidermal Growth Factor; Humans; Lymphoma; Mice; Molecular Weight; Phosphoproteins; Protein Kinase C; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Evidence that stimulation of growth following long term density arrest of WI-38 cells proceeds via a pathway independent of protein kinase C and of cAMP-dependent protein kinase.
Topics: Cell Division; Cells, Cultured; DNA; Epidermal Growth Factor; Fetal Blood; Humans; Protein Kinase C; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate | 1989 |
The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein.
Topics: Base Sequence; Breast Neoplasms; DNA-Binding Proteins; DNA, Neoplasm; Enhancer Elements, Genetic; Epidermal Growth Factor; Estrogens; Female; Gene Expression Regulation; Humans; Molecular Sequence Data; Neoplasm Proteins; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcription Factors; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1989 |
An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.
Topics: Binding Sites; Cloning, Molecular; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression Regulation; HeLa Cells; Humans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription Factors | 1989 |
Epidermal growth factor modulates release of arachidonic acid from embryonic cells.
Topics: Animals; Arachidonic Acids; Calcimycin; Cells, Cultured; Embryo, Mammalian; Enzyme Activation; Epidermal Growth Factor; Gestational Age; Kinetics; Mice; Mice, Inbred C57BL; Models, Biological; Phospholipases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Epidermal growth factor increases inhibin synthesis by isolated segments of rat seminiferous tubules.
Topics: Animals; Culture Techniques; Drug Interactions; Edetic Acid; Epidermal Growth Factor; Follicle Stimulating Hormone; Inhibins; Insulin; Male; Rats; Rats, Inbred Strains; Seminiferous Tubules; Testis; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-alpha in a breast cancer cell line.
Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; beta-N-Acetylhexosaminidases; Breast Neoplasms; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Hexosaminidase A; Humans; Precipitin Tests; Protein Kinase C; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.
Topics: Animals; Calcimycin; Cell Differentiation; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Interleukin-3; Mast Cells; Mice; Oncogene Proteins; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1989 |
The distal enhancer region of the rat prolactin gene contains elements conferring response to multiple hormones.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP; DNA, Recombinant; Enhancer Elements, Genetic; Epidermal Growth Factor; Estradiol; Gene Expression Regulation; Hormones; Luciferases; Prolactin; Promoter Regions, Genetic; Rats; Tetradecanoylphorbol Acetate; Thymidine Kinase; Thyrotropin-Releasing Hormone; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1989 |
Nerve growth factor regulates gene expression by several distinct mechanisms.
Topics: Animals; Blotting, Northern; Bucladesine; Cholera Toxin; Cloning, Molecular; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression Regulation; Genes, Regulator; Insulin; Nerve Growth Factors; Rats; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Regulation of epidermal growth factor receptor gene expression.
Topics: Cell Line; Cells, Cultured; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Placenta; Promoter Regions, Genetic; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 1989 |
Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway.
Topics: Animals; Cell Division; Cell Line; Cyclic AMP; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Heparin; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; RNA, Messenger; Tetradecanoylphorbol Acetate | 1989 |
AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; DNA-Binding Proteins; Epidermal Growth Factor; Epidermis; Gene Expression Regulation; Genetic Variation; Kinetics; Mice; Nucleic Acid Hybridization; Plasmids; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Simplexvirus; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection | 1989 |
EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mitosis; Muscles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinases; Protein Phosphatase 2; Rabbits; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate | 1989 |
Response of rat inner medullary collecting duct to epidermal growth factor.
Topics: Animals; Arachidonic Acids; Cells, Cultured; Cyclic AMP; Dinoprostone; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Kinetics; Male; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1989 |
Epidermal growth factor stimulates tissue plasminogen activator activity and messenger ribonucleic acid levels in cultured rat granulosa cells: mediation by pathways independent of protein kinases-A and -C.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cycloheximide; Epidermal Growth Factor; Extracellular Space; Female; Follicle Stimulating Hormone; Granulosa Cells; Pituitary Hormone-Releasing Hormones; Rats; Rats, Inbred Strains; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Transforming Growth Factors | 1989 |
Epidermal growth factor stimulation of prostacyclin production by cultured aortic smooth muscle cells: requirement for increased cellular calcium levels.
Topics: 6-Ketoprostaglandin F1 alpha; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Arginine Vasopressin; Calcium; Calcium Channel Blockers; Calcium Chloride; Cell Line; Cyclic GMP; Epidermal Growth Factor; Gallic Acid; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Tetradecanoylphorbol Acetate | 1989 |
Effect of lipoxygenase products on choriogonadotropin secretion by cultured human choriocarcinoma JEG-3 cells pre- and post-stimulation with epidermal growth factor and a phorbol ester.
Topics: Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Epidermal Growth Factor; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene A4; Leukotrienes; Lipoxygenase; Phorbol Esters; Pregnancy; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Neoplasms | 1989 |
Induction of protooncogene fos by extracellular signals in primary glial cell cultures.
Topics: Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Cyclic AMP; DNA-Binding Proteins; Epidermal Growth Factor; Ibotenic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate | 1989 |
Selective inhibition of nerve growth factor-stimulated protein kinases by K-252a and 5'-S-methyladenosine in PC12 cells.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Carbazoles; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Indole Alkaloids; Microtubule-Associated Proteins; Nerve Growth Factors; Oligopeptides; Pheochromocytoma; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover.
Topics: Bradykinin; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Trifluoperazine | 1989 |
Proliferating, transformed keratinocytes cultured under low Ca2+ conditions exhibit high-affinity epidermal growth factor receptors.
Topics: Antibodies, Monoclonal; Calcium; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Humans; Keratinocytes; Simian virus 40; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Characterization of a mitogen-activated, Ca2+-sensitive microtubule-associated protein-2 kinase.
Topics: Animals; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Microtubule Proteins; Protein Kinases; Protein Synthesis Inhibitors; Rats; Subcellular Fractions; Substrate Specificity; Swine; Tetradecanoylphorbol Acetate | 1989 |
A common mechanism for activation of the Na+/H+ exchanger by different types of stimuli.
Topics: Bradykinin; Carrier Proteins; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Inhibition of epidermal growth factor receptor tyrosine kinase activity in A431 human epidermoid cells following psoralen/ultraviolet light treatment.
Topics: Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Psoriasis; PUVA Therapy; Tetradecanoylphorbol Acetate | 1989 |
Effects of hormones and intracellular mediators on differentiated functions of cultured Leydig tumor cells.
Topics: Animals; Chorionic Gonadotropin; Cyclic AMP; Epidermal Growth Factor; Hormones; Inositol 1,4,5-Trisphosphate; Leydig Cell Tumor; Leydig Cells; Male; Mice; Oncogenes; Progesterone; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells.
Topics: Animals; Axons; Bucladesine; Cell Differentiation; Dexamethasone; Enzyme Induction; Epidermal Growth Factor; Fibroblast Growth Factors; Matrix Metalloproteinase 3; Metalloendopeptidases; Nerve Growth Factors; Neurons; Pheochromocytoma; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1989 |
Differential regulation of oncogenic and cellular p185 by serine/threonine kinases.
Topics: Cell Division; Cell Line; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Membrane Proteins; Mutation; Oncogene Proteins; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor, ErbB-2; Serine; Tetradecanoylphorbol Acetate; Threonine | 1989 |
Receptor specific for certain nucleotides stimulates inositol phosphate metabolism and Ca2+ fluxes in A431 cells.
Topics: Adenosine Triphosphate; Calcium; Carcinoma, Squamous Cell; Chlortetracycline; Cytoskeletal Proteins; Down-Regulation; Epidermal Growth Factor; Fluorescence; Humans; Inositol Phosphates; Nucleotides; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Purinergic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uridine Triphosphate | 1989 |
H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Epidermis; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Regulation of cathepsin-D and pS2 gene expression by growth factors in MCF7 human breast cancer cells.
Topics: Breast Neoplasms; Cathepsin D; Cycloheximide; Dose-Response Relationship, Drug; Epidermal Growth Factor; Estradiol; Fibroblast Growth Factors; Gene Expression Regulation; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Neoplasm Proteins; Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1989 |
Studies on intimal smooth muscle cells in rabbits: decreased growth response to the tumor promoter.
Topics: Animals; Aorta; Arteriosclerosis; Cell Division; Cells, Cultured; Diet, Atherogenic; Epidermal Growth Factor; Insulin; Kinetics; Male; Muscle, Smooth, Vascular; Rabbits; Serotonin; Tetradecanoylphorbol Acetate | 1989 |
[Cell growth control by growth factors].
Topics: Animals; Cell Division; Collagen; DNA; Epidermal Growth Factor; ErbB Receptors; Insulin; Oncogenes; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1989 |
Stimulation of phosphatidylcholine breakdown and diacylglycerol production by growth factors in Swiss-3T3 cells.
Topics: Animals; Bombesin; Bradykinin; Cells, Cultured; Diglycerides; Dinoprost; Epidermal Growth Factor; Glycerides; Growth Substances; Hydrolysis; Insulin; Kinetics; Mice; Phosphatidylcholines; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Vasopressins | 1989 |
Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.
Topics: DNA; Dose-Response Relationship, Drug; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; In Vitro Techniques; Precipitin Tests; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate | 1989 |
Phenobarbital decreases hepatocyte EGF receptor expression independent of protein kinase C activation.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Liver; Phenobarbital; Protein Kinase C; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C inhibition of the epidermal growth factor receptor tyrosine protein kinase activity is independent of the oligomeric state of the receptor.
Topics: Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Macromolecular Substances; Molecular Weight; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1989 |
A novel calcium signalling response in the breast cancer cell line MDA-468.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Breast Neoplasms; Calcium; Cell Line; Chlorides; Epidermal Growth Factor; Female; Fluorides; Humans; Kinetics; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
HeLa cell mutants resistant to epidermal growth factor ricin A-chain conjugate.
Topics: Adenoviridae; Ammonium Chloride; Cell Separation; Diphtheria Toxin; Drug Resistance; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Mutation; Ricin; Tetradecanoylphorbol Acetate | 1989 |
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Digitonin; Epidermal Growth Factor; Kinetics; Nerve Growth Factors; Pheochromocytoma; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Regulation of transforming growth factor alpha messenger RNA expression in a chemically transformed rat hepatic epithelial cell line by phorbol ester and hormones.
Topics: Animals; Cell Transformation, Neoplastic; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Hormones; In Vitro Techniques; Liver; Protein Kinase C; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transforming Growth Factors | 1989 |
Transforming growth factor-alpha expression in the anterior pituitary gland: regulation by epidermal growth factor and phorbol ester in dispersed cells.
Topics: Animals; Blotting, Northern; Cattle; Cells, Cultured; Epidermal Growth Factor; Gene Expression Regulation; Pituitary Gland, Anterior; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1989 |
Bradykinin blocks the action of EGF, but not PDGF, on fibroblast division.
Topics: Blood; Bradykinin; Cell Division; Cells, Cultured; DNA; Embryo, Mammalian; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Insulin-Like Growth Factor I; Lung; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor.
Topics: Adenylyl Cyclases; Cell Line; Epidermal Growth Factor; Humans; Neoplasm Proteins; Osteosarcoma; Parathyroid Hormone; Parathyroid Hormone-Related Protein; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
The phosphorylation of protein kinase C as a potential measure of activation.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.
Topics: Animals; Binding, Competitive; Carcinogens; Cells, Cultured; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Female; Kinetics; Liver; Phenobarbital; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Global modulation of the epidermal growth factor receptor is triggered by occupancy of only a few receptors. Evidence for a binary regulatory system in normal human fibroblasts.
Topics: Animals; Cell Line; Cell Membrane; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Homeostasis; Humans; Kinetics; Male; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate; Transfection | 1989 |
Regulation of thyroid peroxidase activity by thyrotropin, epidermal growth factor and phorbol ester in porcine thyroid follicles cultured in suspension.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Iodide Peroxidase; Iodides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors | 1989 |
Induction and suppression of type I collagenase in cultured human cells.
Topics: Carcinoma, Squamous Cell; Cell Line; Concanavalin A; Dexamethasone; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Humans; Microbial Collagenase; Molecular Weight; Ocular Physiological Phenomena; Tetradecanoylphorbol Acetate | 1987 |
Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenosine Triphosphate; Cell Line; Cell Membrane; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Phosphotransferases; Tetradecanoylphorbol Acetate | 1987 |
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone.
Topics: Animals; Arthritis, Rheumatoid; Base Sequence; Cholera Toxin; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Gene Expression Regulation; Interleukin-1; Matrix Metalloproteinase 3; Metalloendopeptidases; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Rabbits; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Wound Healing | 1987 |
Induction of glucagon sensitivity in a transformed kidney cell line by prostaglandin E2 and its inhibition by epidermal growth factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood; Cell Differentiation; Cell Line, Transformed; Cyclic AMP; Dinoprostone; Dogs; Epidermal Growth Factor; Glucagon; Kidney; Prostaglandins; Prostaglandins E; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides but does not affect phosphoinositide breakdown by phospholipase C in renal cortical slices.
Topics: Animals; Calcium; Culture Techniques; Cyclic AMP; Cyclic GMP; Epidermal Growth Factor; Female; Inositol Phosphates; Kidney Cortex; Phosphates; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Activation and proliferation signals in murine macrophages: stimulation of glucose uptake by hemopoietic growth factors and other agents.
Topics: Animals; Bone Marrow Cells; Cell Division; Cell Survival; Colony-Stimulating Factors; Concanavalin A; Deoxyglucose; DNA; Epidermal Growth Factor; Glucose; Growth Substances; Hematopoietic Cell Growth Factors; Interleukin-3; Macrophages; Male; Mice; Mice, Inbred C3H; Mice, Inbred CBA; Peritoneal Cavity; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate | 1988 |
Dual regulation of 3 beta-hydroxysteroid dehydrogenase, 17 alpha-hydroxylase, and dehydroepiandrosterone sulfotransferase by adenosine 3',5'-monophosphate and activators of protein kinase C in cultured human adrenocortical cells.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Angiotensin II; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; Kinetics; Protein Kinase C; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Sulfotransferases; Sulfurtransferases; Tetradecanoylphorbol Acetate | 1988 |
Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Chromatography, High Pressure Liquid; Drug Synergism; Epidermal Growth Factor; Epinephrine; Growth Substances; Hormones; Phosphatidylinositols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Mitogenic effects of thyrotropin and adenosine 3',5'-monophosphate in differentiated normal human thyroid cells in vitro.
Topics: Adenosine Monophosphate; Adolescent; Adult; Blood Physiological Phenomena; Cell Differentiation; Cell Division; Cells, Cultured; Child; Cyclic AMP; DNA; Epidermal Growth Factor; Humans; Middle Aged; Mitogens; Reference Values; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1988 |
The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable.
Topics: Animals; Bucladesine; Cell Nucleus; Chromaffin System; Cycloheximide; Dexamethasone; Epidermal Growth Factor; Gene Expression Regulation; Nerve Growth Factors; Nerve Tissue Proteins; Pheochromocytoma; Proto-Oncogene Proteins; Rats; RNA, Messenger; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Tumor Cells, Cultured | 1988 |
Epidermal growth factor but not insulin-like growth factor-I potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Binding, Competitive; Cholera Toxin; Choriocarcinoma; Chorionic Gonadotropin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Kinetics; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Epidermal growth factor (EGF) and hormones stimulate phosphoinositide hydrolysis and increase EGF receptor protein synthesis and mRNA levels in rat liver epithelial cells. Evidence for protein kinase C-dependent and -independent pathways.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cell Line; Enzyme Activation; Epidermal Growth Factor; Epinephrine; Epithelium; ErbB Receptors; Hydrolysis; Inositol; Inositol Phosphates; Kinetics; Liver; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Protein Kinase C; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1988 |
Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes.
Topics: Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Epidermal Growth Factor; Heat-Shock Proteins; Humans; Molecular Sequence Data; Nerve Growth Factors; Promoter Regions, Genetic; Proto-Oncogenes; Rats; Tetradecanoylphorbol Acetate | 1988 |
Epidermal growth factor-stimulated DNA synthesis requires an influx of extracellular calcium.
Topics: Animals; Bradykinin; Calcium; Calcium Channel Agonists; Calcium Channels; Cell Division; Cell Membrane; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Rats; Tetradecanoylphorbol Acetate | 1988 |
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; Golgi Apparatus; Histocytochemistry; Humans; Lysosomes; Phorbols; Protein Kinase C; Protein Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.
Topics: Animals; Calcium; Cells, Cultured; Chromaffin Granules; Clone Cells; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Molecular Weight; Nerve Growth Factors; Phosphopeptides; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Tyrosine 3-Monooxygenase | 1985 |
Stimulation of arachidonic acid metabolism by different types of tumor promoters.
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Line; Cnidarian Venoms; Drug Synergism; Epidermal Growth Factor; Liver; Peptides; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry.
Topics: Animals; Biological Transport, Active; Clathrin; Coated Pits, Cell-Membrane; Endosomes; Epidermal Growth Factor; ErbB Receptors; Half-Life; Humans; Immunosorbent Techniques; Kinetics; Rabbits; Receptors, Cell Surface; Receptors, Transferrin; Surface Properties; Tetradecanoylphorbol Acetate | 1985 |
Protein kinase C-activating tumor promoters enhance the differentiation of astrocytes in aggregating fetal brain cell cultures.
Topics: Animals; Astrocytes; Brain; Carcinogens; Cell Aggregation; Cell Differentiation; Cells, Cultured; Diterpenes; Embryo, Mammalian; Enzyme Activation; Epidermal Growth Factor; Glutamate-Ammonia Ligase; Protein Kinase C; Rats; Rats, Inbred Strains; Telencephalon; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Bryostatins; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Activation; Epidermal Growth Factor; Epidermis; Lactones; Macrolides; Mice; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1987 |
Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.
Topics: Adenocarcinoma; Autoradiography; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Humans; Immunoassay; Peptide Mapping; Phosphorylation; Proto-Oncogene Proteins; Receptor, ErbB-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Rapid phosphorylation of MAP-2-related cytoplasmic and nuclear Mr 300,000 protein by serine kinases after growth stimulation in quiescent cells.
Topics: Animals; Calcimycin; Cell Compartmentation; Cell Cycle; Cell Nucleus; Chemical Precipitation; Cytoplasm; Diglycerides; Egtazic Acid; Epidermal Growth Factor; Growth Substances; Immunologic Techniques; Insulin; Microtubule-Associated Proteins; Molecular Weight; Phosphoproteins; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Tetradecanoylphorbol Acetate; Time Factors; Transferrin; Tretinoin | 1988 |
Inhibitors of ADP-ribosyl transferase suppress the mitogenic actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Benzamides; Carcinogens; Cell Cycle; Cell Nucleus; DNA; Epidermal Growth Factor; In Vitro Techniques; Liver; Mitogens; NAD; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Tetradecanoylphorbol Acetate | 1988 |
Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations.
Topics: Adipose Tissue; Angiogenesis Inducing Agents; Blood; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Endothelium; Enzyme Induction; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; Humans; Liver Neoplasms; Microbial Collagenase; Mitogens; Plasminogen Activators; Retina; Tetradecanoylphorbol Acetate; Tissue Extracts; Umbilical Veins | 1985 |
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Glycerides; Humans; Mice; Mitosis; Phorbol Esters; Phorbols; Phospholipids; Phosphoproteins; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters stimulate growth and inhibit differentiation in cultured thyroid cells.
Topics: Animals; Biological Transport; Cell Differentiation; Cell Division; Cells, Cultured; Cyclic AMP; Diglycerides; DNA; Epidermal Growth Factor; Iodine; Phorbols; Sheep; Tetradecanoylphorbol Acetate; Thyroid Gland; Time Factors | 1985 |
Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter.
Topics: Animals; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Peptides; Phorbols; Rats; Receptors, Cell Surface; Sarcoma Viruses, Feline; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
EGF receptor affinity is regulated by intracellular calcium and protein kinase C.
Topics: Animals; Calcimycin; Calcium; Carcinoma, Squamous Cell; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
Effects of epidermal growth factor, phorbol myristate acetate, and arachidonic acid on choriogonadotropin secretion by cultured human choriocarcinoma cells.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Catechols; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Indomethacin; Masoprocol; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pregnancy; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 1985 |
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.
Topics: Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Oncogenes; Peptide Fragments; Phorbols; Phosphorylation; Platelet-Derived Growth Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine | 1985 |
The Na+/H+ antiport is activated by serum and phorbol esters in proliferating myoblasts but not in differentiated myotubes. Properties of the activation process.
Topics: Amiloride; Animals; Blood; Carrier Proteins; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Epidermal Growth Factor; Hydrogen-Ion Concentration; Kinetics; Muscle Development; Phorbol Esters; Phorbols; Rats; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1985 |
Antiproliferative properties of phorbol ester tumour promoters.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Epidermal Growth Factor; Humans; Hydroxides; Hydroxyl Radical; Neutrophils; Oxygen; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Induction of the proto-oncogene fos by nerve growth factor.
Topics: Animals; Bucladesine; Cell Differentiation; Cell Line; Dexamethasone; Epidermal Growth Factor; Gene Expression Regulation; Neoplasm Proteins; Nerve Growth Factors; Pheochromocytoma; Potassium; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Rats; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transcriptional Activation | 1985 |
Enhancement by 1 alpha,25-dihydroxyvitamin D3 of chemically induced transformation of BALB 3T3 cells without induction of ornithine decarboxylase or activation of protein kinase C1.
Topics: Animals; Caenorhabditis elegans Proteins; Calcitriol; Carrier Proteins; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA; Drug Synergism; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; ErbB Receptors; Methylcholanthrene; Mice; Ornithine Decarboxylase; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate | 1986 |
c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF.
Topics: Animals; Bradykinin; Cell Division; Cell Line; Diglycerides; DNA; Enzyme Activation; Epidermal Growth Factor; Humans; Mitogens; Phosphatidylinositols; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine; Vasopressins | 1985 |
Epidermal growth factor regulates the expression of its own receptor.
Topics: Cells, Cultured; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Kinetics; Phorbols; Receptors, Cell Surface; RNA, Messenger; Tetradecanoylphorbol Acetate | 1985 |
Tumor promoter enhances mitogenesis by PDGF with little effect on PDGF binding.
Topics: Animals; Cell Division; Cell Line; DNA Replication; Drug Synergism; Epidermal Growth Factor; Fibroblasts; Mice; Phorbols; Platelet-Derived Growth Factor; Receptors, Cell Surface; Receptors, Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1986 |
Effect of phorbol esters on the activity of purified transforming growth factors.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Kidney; Peptides; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1986 |
Correlation between hormone dependency and the regulation of epidermal growth factor receptor by tumor promoters in human mammary carcinoma cells.
Topics: Breast Neoplasms; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Estrogens; Humans; Lyngbya Toxins; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phorbols; Progesterone; Protein Kinase C; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Progesterone; Tetradecanoylphorbol Acetate | 1986 |
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms.
Topics: Alanine; Cell Line; DNA; Epidermal Growth Factor; ErbB Receptors; Humans; Methionine; Mutation; Phosphorylation; Protein Conformation; Protein Kinase C; Receptors, Cell Surface; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Threonine; Transcription, Genetic | 1986 |
Regulation of VL30 gene expression by activators of protein kinase C.
Topics: Animals; Base Sequence; Cell Line; Diglycerides; Embryo, Mammalian; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, Viral; Kinetics; Mice; Phorbol Esters; Protein Biosynthesis; Protein Kinase C; Receptors, Cell Surface; Retroviridae; Tetradecanoylphorbol Acetate | 1986 |
Growth factors activate the bumetanide-sensitive Na+/K+/Cl-cotransport in hamster fibroblasts.
Topics: Animals; Biological Transport, Active; Bumetanide; Carrier Proteins; Cells, Cultured; Chlorides; Cricetinae; Diuretics; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Growth Substances; Ouabain; Potassium; Protein Kinase C; Rubidium; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Regulation of interacting populations during endocytosis: models of growth factor-tumor promoter dynamics.
Topics: Animals; Carcinogens; Cells; Coated Pits, Cell-Membrane; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Forecasting; Kinetics; Ligands; Membrane Proteins; Mice; Models, Biological; Phorbol Esters; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1986 |
Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol.
Topics: Calcium; Calcium Radioisotopes; Carcinoma, Squamous Cell; Cell Line; Diglycerides; Epidermal Growth Factor; Humans; Kinetics; Phosphatidylinositols; Protons; Sodium; Sodium Radioisotopes; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1986 |
Effect of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on the phosphorylation of soluble acidic proteins in A431 epidermoid carcinoma cells.
Topics: Bucladesine; Carcinoma, Squamous Cell; Cells, Cultured; Cytosol; Epidermal Growth Factor; Humans; Molecular Weight; Phorbols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Proteins; Tetradecanoylphorbol Acetate | 1986 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on epidermal growth factor receptors in BALB/c-3T3 cells: relationship between receptor modulation and mitogenesis.
Topics: Animals; Cell Cycle; Cell Line; Culture Media; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Insulin; Mice; Mitogens; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Effects of protein kinase C activation after epidermal growth factor binding on epidermal growth factor receptor phosphorylation.
Topics: Cell Line; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphorylation; Protein Kinase C; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1986 |
Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.
Topics: Animals; Carcinogens; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Mice; Mitogens; Phorbols; Phosphoproteins; Phosphorylation; Protamine Kinase; Protein Kinases; Protein-Tyrosine Kinases; Proteins; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1985 |
The effect of cAMP on tumour promoter responses mediated by C-kinase.
Topics: Aminophylline; Animals; Bucladesine; Carcinogens; Cell Communication; Cell Line; Cyclic AMP; Diglycerides; Epidermal Growth Factor; Glycerides; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphatidylcholines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Action of retinoic acid on the diacylglycerol-induced ornithine decarboxylase activity, reduction in EGF binding and protein kinase C activation in rat tracheal epithelial 2C5 cells.
Topics: Animals; Cell Line; Diglycerides; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; ErbB Receptors; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Trachea; Tretinoin | 1986 |
Characterization of Fischer rat embryo (CREF) cells transformed by bovine papillomavirus type 1.
Topics: Adenoviruses, Human; Animals; Bovine papillomavirus 1; Cell Cycle; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Mice; Neoplasms, Experimental; Papillomaviridae; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Virus Replication | 1986 |
A possible mechanism of induction and translocation into blood stream of rat alkaline phosphatase activity by bile duct ligation.
Topics: Alkaline Phosphatase; Animals; Bile Ducts; Bone and Bones; Calmodulin; Chlorpromazine; Cholestasis; Cyclic AMP; Enzyme Induction; Epidermal Growth Factor; Fucose; Indomethacin; Intestines; Isoenzymes; Ligation; Liver; Prostaglandins; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1986 |
Enhancement of cmyc mRNA concentration in dog thyrocytes initiating DNA synthesis in response to thyrotropin, forskolin, epidermal growth factor and phorbol myristate ester.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; DNA; Dogs; Epidermal Growth Factor; Nucleic Acid Hybridization; Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1986 |
Both protein kinase C and calcium mediate activation of the Na+/H+ antiporter in Chinese hamster embryo fibroblasts.
Topics: Animals; Calcimycin; Calcium; Carrier Proteins; Cell Line; Cricetinae; Embryo, Mammalian; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Hydrogen-Ion Concentration; Protein Kinase C; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Trifluoperazine | 1987 |
Colchicine acts as a progression factor to initiate DNA synthesis in quiescent Balb/c 3T3 cells.
Topics: Animals; Cell Division; Cell Line; Colchicine; Demecolcine; DNA; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Fibroblast Growth Factors; Insulin; Interphase; Lumicolchicines; Mice; Mice, Inbred BALB C; Microtubules; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1988 |
Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bombesin; Calcium; Cell Line; Dinoprost; DNA; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Hydrogen-Ion Concentration; Inositol Phosphates; Insulin; Interphase; Mitogens; Platelet-Derived Growth Factor; Prostaglandins F; Protein Kinase C; Tetradecanoylphorbol Acetate; Vasopressins | 1988 |
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
Topics: Animals; Cell Membrane; Cells, Cultured; Cytoplasm; Epidermal Growth Factor; Fibroblast Growth Factors; Insulin; Mice; Peptide Mapping; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogenes; Signal Transduction; Tetradecanoylphorbol Acetate | 1988 |
Modified responsiveness of v-Ha-ras-transfected rat fibroblasts to growth factors and a tumor promoter.
Topics: Animals; Blotting, Northern; Bombesin; Carcinogenicity Tests; Carcinogens; Cell Adhesion; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Mice; Mice, Nude; Oncogenes; Phenotype; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Tetradecanoylphorbol Acetate; Transfection | 1988 |
Glucocorticoids antagonize induction of prolactin-gene expression by calcitriol in rat pituitary tumour cells.
Topics: Animals; Calcitriol; Cell Line; Epidermal Growth Factor; Gene Expression Regulation; Glucocorticoids; Hydrocortisone; Male; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1986 |
Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
Topics: Adenylate Cyclase Toxin; Aminoquinolines; Angiotensin II; Animals; Calcium; Diglycerides; Epidermal Growth Factor; Glycerides; GTP-Binding Proteins; Inositol Phosphates; Isoelectric Point; Liver; Male; Molecular Weight; Pertussis Toxin; Phorbols; Phosphoproteins; Rats; Sugar Phosphates; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1986 |
Effect of protein kinase C activation and Ca2+ mobilization on hexose transport in Swiss 3T3 cells.
Topics: 3-O-Methylglucose; Animals; Biological Transport, Active; Calcimycin; Calcium; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Insulin; Kinetics; Methylglucosides; Methylglycosides; Mice; Platelet-Derived Growth Factor; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Inducible binding of a factor to the c-fos enhancer.
Topics: Calcium; Carcinoma, Squamous Cell; Cell Line; DNA-Binding Proteins; DNA, Neoplasm; Enhancer Elements, Genetic; Epidermal Growth Factor; Genes, Regulator; HeLa Cells; Humans; Neoplasm Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1986 |
Modulation of arachidonic acid metabolism in a cultured newborn rat keratinocyte cell line.
Topics: Animals; Animals, Newborn; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cell Line; Dexamethasone; Diglycerides; Epidermal Growth Factor; Melitten; Prostaglandin-Endoperoxide Synthases; Rats; Skin; Tetradecanoylphorbol Acetate | 1987 |
A novel synthetic vitamin A-like compound (a polyprenoic acid derivative, E-5166) inhibits the release of arachidonic acid stimulated by epidermal growth factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Epidermal Growth Factor; Phosphatidylinositols; Skin; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1987 |
Stimulation of prostaglandin E2 production by phorbol esters and epidermal growth factor in porcine thyroid cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; Kinetics; Prostaglandins E; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1987 |
The phorbol ester, TPA, increases transepithelial epidermal growth factor flux.
Topics: Cell Line; Diglycerides; Epidermal Growth Factor; Epithelium; Mannitol; Membrane Fluidity; Tetradecanoylphorbol Acetate | 1987 |
c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.
Topics: Calcimycin; Calcium; DNA Mutational Analysis; DNA-Binding Proteins; Enhancer Elements, Genetic; Epidermal Growth Factor; Gene Expression Regulation; Humans; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogenes; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1987 |
Epidermal growth factor (EGF), tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187 increase cytoplasmic free calcium and stimulate arachidonic acid release and PGE2/6-keto PGF1 alpha production in cultured porcine thyroi
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Calcium; Cells, Cultured; Cytoplasm; Dinoprostone; Epidermal Growth Factor; Fluorescent Dyes; Fura-2; Kinetics; Prostaglandins; Prostaglandins E; Spectrometry, Fluorescence; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1987 |
Regulation of inhibin production by rat granulosa cells.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Hydrocortisone; Inhibins; Insulin; Luteinizing Hormone; Pituitary Hormone-Releasing Hormones; Rats; Receptors, LH; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Drug Synergism; Epidermal Growth Factor; Glomerular Mesangium; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Vasopressins | 1988 |
The EL2 rat fibroblasts line: differential effects of growth factors (EGF, PDGF, FGF, TPA and TGF beta) on cell proliferation and c-fos expression.
Topics: Animals; Cell Division; Cell Line; Culture Media; DNA Replication; Drug Synergism; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Gene Expression Regulation; Growth Substances; Peptides; Platelet-Derived Growth Factor; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1987 |
The pp60v-src tyrosine kinase desensitizes epidermal growth factor binding to 3T3 fibroblasts by two distinct protein kinase C-independent mechanisms.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Kinetics; Mice; Oncogene Protein pp60(v-src); Phosphorylation; Protein-Tyrosine Kinases; Retroviridae Proteins; Tetradecanoylphorbol Acetate; Thermodynamics | 1988 |
Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor.
Topics: Animals; Base Sequence; Cell Line; Cloning, Molecular; Epidermal Growth Factor; ErbB Receptors; Mice; Mutation; Phosphorylation; Tetradecanoylphorbol Acetate; Threonine; Transfection | 1988 |
Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin.
Topics: Bradykinin; Calcimycin; Calcium; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epidermal Growth Factor; Histamine; Humans; Inositol Phosphates; Kinetics; Pertussis Toxin; Sugar Phosphates; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1988 |
Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Diethylhexyl Phthalate; Egtazic Acid; Epidermal Growth Factor; Mice; Mice, Inbred BALB C; Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection | 1988 |
Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis.
Topics: Animals; Aphidicolin; Bone and Bones; Bone Resorption; Calcium; Diterpenes; DNA Replication; Epidermal Growth Factor; Flufenamic Acid; Indomethacin; Organ Culture Techniques; Parathyroid Hormone; Phorbol Esters; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Thymidine | 1988 |
Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.
Topics: Calcimycin; Cell Division; Cell Line; Epidermal Growth Factor; Humans; Oncogenes; Protein Biosynthesis; Protein Kinase C; Protein Kinases; Proto-Oncogene Mas; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Dual actions of phorbol esters on cytosolic free Ca2+ concentrations and reconstitution with ionomycin of acute thyrotropin-releasing hormone responses.
Topics: Animals; Anti-Bacterial Agents; Caenorhabditis elegans Proteins; Calcium; Carrier Proteins; Cells, Cultured; Cytosol; Diterpenes; Egtazic Acid; Epidermal Growth Factor; Ethers; Insulin; Ionomycin; Phorbols; Pituitary Gland; Potassium; Protein Kinase C; Protein Kinases; Rats; Receptors, Drug; Receptors, Immunologic; Terpenes; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |
Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cell Line; Dexamethasone; DNA Replication; Epidermal Growth Factor; Estradiol; Female; Growth Substances; Humans; Kinetics; Peptides; Progesterone; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factors | 1988 |
Isolation and characterization of A-431 cells that retain high epidermal growth factor binding capacity and respond to epidermal growth factor by growth stimulation.
Topics: Epidermal Growth Factor; ErbB Receptors; Humans; Peptides; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tretinoin; Tumor Cells, Cultured | 1988 |
Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.
Topics: Blood; Calcium; Caseins; Cell Line; Chromatography, Gel; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Histones; Humans; Insulin-Like Growth Factor I; Lung; Microtubule-Associated Proteins; Phorbol Esters; Phosphopeptides; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Ribosomal Protein S6 Kinases; Substrate Specificity; Tetradecanoylphorbol Acetate | 1988 |
Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C.
Topics: Animals; Calcium; Cell Line; Chromatography, High Pressure Liquid; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Inositol Phosphates; Kinetics; Protein Kinase C; Sphingosine; Sugar Phosphates; Tamoxifen; Tetradecanoylphorbol Acetate | 1988 |
Mitogen-stimulated tyrosine phosphorylation of a 42-kD cellular protein: evidence for a protein kinase-C requirement.
Topics: Animals; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Mitogens; Molecular Weight; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1988 |
Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.
Topics: Animals; Cell Line; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Glycerides; Mice; Multigene Family; Protein Kinase C; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Epidermal growth factor, vanadate, and 12-O-tetradecanoylphorbol-13-acetate inhibit growth and stimulate prostaglandin E2 production in A431 cells.
Topics: Cell Line; Dinoprostone; Epidermal Growth Factor; Humans; Prostaglandins E; Tetradecanoylphorbol Acetate; Thymidine; Tritium; Tumor Cells, Cultured; Vanadates | 1988 |
Differential protein phosphorylation in induction of thyroid cell proliferation by thyrotropin, epidermal growth factor, or phorbol ester.
Topics: Animals; Cell Division; Cells, Cultured; Dogs; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Molecular Weight; Phosphoproteins; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1988 |
Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1).
Topics: Cells, Cultured; Epidermal Growth Factor; Epithelium; Kidney; Mitosis; Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Growth factors rapidly induce expression of the glucose transporter gene.
Topics: Animals; Anisomycin; Blood; Cell Line; Cycloheximide; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression Regulation; Growth Substances; Kinetics; Mice; Monosaccharide Transport Proteins; Nucleic Acid Hybridization; Platelet-Derived Growth Factor; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.
Topics: Animals; DNA Mutational Analysis; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Mice; Mitogens; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transfection | 1988 |
Effects of epidermal growth factor and phorbol 12-myristate 13-acetate on protein phosphorylation in mouse embryo palate mesenchyme cells in vitro.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Mesoderm; Mice; Mice, Inbred A; Molecular Weight; Palate; Phosphoproteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Regulation of human chorionic somatomammotropin gene expression in rat pituitary tumour cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Chloramphenicol O-Acetyltransferase; Dexamethasone; DNA, Recombinant; Epidermal Growth Factor; Gene Expression Regulation; Glucose; Humans; Insulin-Like Growth Factor II; Pituitary Gland, Anterior; Pituitary Neoplasms; Placental Lactogen; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Triiodothyronine; Tumor Cells, Cultured | 1988 |
Growth factor- and phorbol ester-induced changes in cell morphology analyzed by digital image processing.
Topics: Actins; Animals; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cell Movement; Epidermal Growth Factor; Fibroblasts; Growth Substances; Humans; Image Processing, Computer-Assisted; Insulin; Somatomedins; Temperature; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
The glucose transporter in human fibroblasts is phosphorylated in response to phorbol ester but not in response to growth factors.
Topics: Epidermal Growth Factor; Fibroblasts; Growth Substances; Humans; Insulin; Kinetics; Monosaccharide Transport Proteins; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1987 |
Mitogen-activated S6 kinase is stimulated via protein kinase C-dependent and independent pathways in Swiss 3T3 cells.
Topics: Amino Acid Sequence; Animals; Autoradiography; Enzyme Activation; Epidermal Growth Factor; Insulin; Isoenzymes; Mice; Mitogens; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Somatomedins; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
The epidermal growth factor-induced calcium signal in A431 cells.
Topics: Aminoquinolines; Blood; Calcium; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; Humans; Lanthanum; Manganese; Mathematics; Membrane Potentials; Potassium; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Mimicry of phorbol ester responses by diacylglycerols. Differential effects on phosphatidylcholine biosynthesis, cell-cell communication and epidermal growth factor binding.
Topics: Animals; Cell Communication; Cell Line; Diglycerides; Epidermal Growth Factor; Epidermis; Glycerides; Intercellular Junctions; Mice; Phorbols; Phosphatidylcholines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Comparison of the activity of phorbol 12-myristate 13-acetate and the diglyceride glycerol 1-myristate 2-acetate.
Topics: Animals; Cell Line; Diglycerides; Epidermal Growth Factor; Fibroblasts; Glycerides; Mice; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Possible role of protein phosphorylation in the mitogenic effect of high density lipoproteins on cultured vascular endothelial cells.
Topics: Amino Acids; Animals; Aorta, Thoracic; Cattle; Cells, Cultured; Diglycerides; Endothelium; Epidermal Growth Factor; Fibroblast Growth Factors; Humans; Kinetics; Lipoproteins, HDL; Phosphorylation; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1986 |
Familial polyposis coli: growth characteristics of karyotypically variable cultured fibroblasts, response to epidermal growth factor and the tumour promoter 12-0-tetradecanoyl phorbol-13-acetate.
Topics: Cell Adhesion; Cell Count; Cell Division; Cells, Cultured; Chromosome Aberrations; Colonic Polyps; Culture Media; Epidermal Growth Factor; Fibroblasts; Humans; Karyotyping; Skin; Tetradecanoylphorbol Acetate | 1986 |
The role of EGF receptor transmodulation in embryonal carcinoma-derived growth factor-induced mitogenesis.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Growth Substances; Kinetics; Mice; Mice, Inbred C3H; Peptides; Phosphorylation; Tetradecanoylphorbol Acetate | 1986 |
Psoralens potentiate ultraviolet light-induced inhibition of epidermal growth factor binding.
Topics: Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Furocoumarins; Iodine Radioisotopes; Skin; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1986 |
Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters.
Topics: Animals; Base Sequence; Enhancer Elements, Genetic; Epidermal Growth Factor; Genes, Regulator; Genes, Viral; Moloney murine leukemia virus; Prolactin; Promoter Regions, Genetic; Rats; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1986 |
Activation of proto-oncogene expression by growth regulatory signals.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; Genes, Regulator; Mice; Proto-Oncogenes; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of epidermal growth factor binding to HeLa cells by auranofin.
Topics: Auranofin; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor induces cytogenetic damage in mammalian cells.
Topics: Cell Line; Epidermal Growth Factor; Protein Kinase C; Sister Chromatid Exchange; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor (EGF) and tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulate PG synthesis and thymidine incorporation in cultured porcine thyroid cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; Prostaglandins; Prostaglandins E; Swine; Tetradecanoylphorbol Acetate; Thymidine; Thyroid Gland | 1987 |
Bombesin induces c-fos and c-myc expression in quiescent Swiss 3T3 cells. Comparative study with other mitogens.
Topics: Animals; Bombesin; Cell Transformation, Neoplastic; Cells, Cultured; DNA Replication; Epidermal Growth Factor; Mice; Mitogens; Platelet-Derived Growth Factor; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1987 |
Lifespan extension of basal cell nevus syndrome fibroblasts by transfection with mouse pro or v-myc genes.
Topics: Adult; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Epidermal Growth Factor; Female; Genetic Engineering; Humans; Male; Phenotype; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor receptor synthesis is stimulated by phorbol ester and epidermal growth factor. Evidence for a common mechanism.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Kinetics; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells.
Topics: Astrocytoma; Carbachol; Cell Line; Epidermal Growth Factor; Humans; Inositol Phosphates; Kinetics; Molecular Weight; Peptide Mapping; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogenes; Ribosomal Protein S6; Ribosomal Proteins; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1987 |
Inhibition of DNA synthesis by phorbol esters through protein kinase C in cultured rabbit aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; DNA Replication; Epidermal Growth Factor; Male; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phorbol Esters; Platelet-Derived Growth Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1987 |
Heterologous regulation of EGF receptors in fibroblastic cells.
Topics: Animals; Cells, Cultured; Cholera Toxin; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Platelet-Derived Growth Factor; Protein Biosynthesis; Tetradecanoylphorbol Acetate | 1987 |
Tumour promoter 12-O-tetradecanoylphorbol 13-acetate and epidermal growth factor stimulate proliferation and inhibit differentiation of porcine thyroid cells in primary culture.
Topics: Animals; Cell Differentiation; Cell Division; Cells, Cultured; Epidermal Growth Factor; Iodine; Swine; Tetradecanoylphorbol Acetate; Thymidine; Thyroid Gland | 1987 |
Effects of epidermal growth factor on transferrin receptor phosphorylation and surface expression in malignant epithelial cells.
Topics: Animals; Antibodies; Binding Sites; Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epithelium; ErbB Receptors; Methionine; Phosphorylation; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Vanadates | 1987 |
Effects of tumor-promoting agents 12-O-tetradecanoylphorbol-13-acetate and phenobarbital on DNA synthesis of rat hepatocytes in primary culture.
Topics: Animals; Cell Count; Cell Cycle; Cells, Cultured; DNA; Epidermal Growth Factor; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thymine Nucleotides; Time Factors | 1987 |
Altered glucocorticoid binding and action in response to epidermal growth factor in HBL100 cells.
Topics: Breast; Cell Line; Concanavalin A; Cytosol; Dexamethasone; Epidermal Growth Factor; Epithelium; Female; Humans; Kinetics; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate | 1987 |
Characterization and control of EGF-stimulated formation of inositol phosphates in A-431 cells.
Topics: Calcium; Cell Line; Epidermal Growth Factor; Humans; Inositol Phosphates; Kinetics; Sugar Phosphates; Tamoxifen; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C-mediated feed back inhibition of the Ca2+ response at the EGF receptor.
Topics: Calcium; Carcinoma, Squamous Cell; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Feedback; Inositol Phosphates; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1987 |
Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5- and inositol 1,3,4-trisphosphate in hepatocytes. Differential inhibition by pertussis toxin and phorbol 12-myristate 13-acetate.
Topics: Aminoquinolines; Angiotensin II; Animals; Calcium; Epidermal Growth Factor; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Male; Pertussis Toxin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sugar Phosphates; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
Induction of transiently expressed genes in PC-12 pheochromocytoma cells.
Topics: Animals; Benzodiazepines; Cell Differentiation; Cell Division; Cell Line; Cycloheximide; Dexamethasone; Diazepam; Epidermal Growth Factor; Gene Expression Regulation; Nerve Growth Factors; Pheochromocytoma; Potassium; Rats; RNA, Messenger; Temazepam; Tetradecanoylphorbol Acetate | 1987 |
Phorbol esters, but not epidermal growth factor or insulin, rapidly decrease soluble protein kinase C activity in rat hepatocytes.
Topics: Animals; Cell Compartmentation; Cells, Cultured; Epidermal Growth Factor; Histones; Insulin; Liver; Male; Phorbols; Protein Kinase C; Rats; Solubility; Tetradecanoylphorbol Acetate | 1986 |
Contradistinctive growth responses of cultured rat intestinal epithelial cells to epidermal growth factor depending on cell population density.
Topics: Animals; Blood; Cell Count; Cell Division; Cell Line; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Insulin; Intestine, Small; Rats; Tetradecanoylphorbol Acetate | 1986 |
Demonstration of an epidermal growth factor-dependent 58 kDa phosphoprotein secreted by rat kidney fibroblasts.
Topics: Animals; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Insulin; Kidney; Mice; Molecular Weight; Nerve Growth Factors; Peptides; Phosphoproteins; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1987 |
Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.
Topics: Animals; Cell Line; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Humans; Interphase; Kinetics; Mice; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1985 |
Dominant and recessive mitogen-nonproliferative variants of 3T3 cells.
Topics: Animals; Cell Division; Cell Line; Cell Physiological Phenomena; Epidermal Growth Factor; Genes, Dominant; Genes, Recessive; Genetic Variation; Mice; Mitogens; Phenotype; Tetradecanoylphorbol Acetate | 1985 |
The modulation of growth of normal rat liver epithelial cells in calcium-poor medium by epidermal growth factor, phenobarbital, phorbol ester, and retinoic acid.
Topics: Animals; Calcium; Cell Division; Cell Line; Cell Survival; Culture Media; Epidermal Growth Factor; Epithelial Cells; Epithelium; Liver; Phenobarbital; Phorbols; Rats; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1985 |
Modulation of type-IV procollagen and laminin production in A431 human squamous epidermoid carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF).
Topics: Basement Membrane; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Line; Drug Synergism; Epidermal Growth Factor; Epithelium; Extracellular Matrix; Humans; Laminin; Neoplasm Proteins; Phorbols; Procollagen; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Interaction of epidermal growth factor with initiators and complete carcinogens in the C3H10T1/2 cell culture system.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Epidermal Growth Factor; Fibroblasts; Methylcholanthrene; Mice; Mice, Inbred C3H; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay | 1985 |
Residual inhibition of epidermal growth factor binding by pancreatic secretagogues and phorbol ester in rat pancreas.
Topics: Animals; Bombesin; Calcium; Carbachol; Dibutyryl Cyclic GMP; Epidermal Growth Factor; Kinetics; Male; Pancreas; Phorbol Esters; Proglumide; Rats; Rats, Inbred Strains; Sincalide; Tetradecanoylphorbol Acetate | 1985 |
Regulation of anchorage-independent growth by thyroid hormone in type 5 adenovirus-transformed rat embryo cells.
Topics: Adenoviruses, Human; Animals; Cell Adhesion; Cell Division; Cell Nucleus; Cell Transformation, Viral; Epidermal Growth Factor; Gene Expression Regulation; Peptide Biosynthesis; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factors; Triiodothyronine | 1985 |
Effects of platelet-derived growth factor on Ca2+ in 3T3 cells.
Topics: Animals; Calcium; Cell Line; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Mice, Inbred BALB C; Platelet-Derived Growth Factor; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1985 |
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.
Topics: Animals; Brain; Cell Line; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Humans; Immunologic Techniques; Insulin; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1985 |
The stimulation by the tumour promoters 12-O-tetradecanoylphorbol-13-acetate and phenobarbital of the growth of primary neonatal rat hepatocytes.
Topics: Animals; Calmodulin; Carcinogens; Cell Division; Egtazic Acid; Epidermal Growth Factor; Female; Imidazoles; In Vitro Techniques; Lanthanum; Liver; Male; Phenobarbital; Phorbols; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate | 1985 |
Thyrotropin-releasing hormone and epidermal growth factor stimulate prolactin synthesis by a pathway(s) that differs from that used by phorbol esters: dissociation of actions by calcium dependency and additivity.
Topics: Animals; Calcium; Cell Line; Epidermal Growth Factor; Inositol Phosphates; Phorbols; Pituitary Gland; Prolactin; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1985 |
Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription.
Topics: Animals; Calcium; Cells, Cultured; Epidermal Growth Factor; Gallopamil; Nifedipine; Phorbols; Phosphorylation; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1985 |
Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cells, Cultured; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Epidermis; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1985 |
Tumor promoter phorbol 12-myristate 13-acetate inhibits mitogen-stimulated Na+/H+ exchange in human epidermoid carcinoma A431 cells.
Topics: Carcinoma, Squamous Cell; Carrier Proteins; Cell Line; Culture Media; Epidermal Growth Factor; Humans; Hydrogen-Ion Concentration; Mannitol; Mitogens; Phorbols; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Vanadates; Vanadium | 1984 |
Eicosapentaenoic acid: its effects on arachidonic acid metabolism by cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Cell Line; Cells, Cultured; Dogs; Eicosapentaenoic Acid; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Liver; Mice; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 1984 |
Activation of amiloride-sensitive sodium transport in C6 glioma cells.
Topics: Amiloride; Animals; Biological Transport, Active; Bradykinin; Bucladesine; Cell Line; Colchicine; Diglycerides; Epidermal Growth Factor; Glioma; Protons; Pyrazines; Rats; Sodium; Tetradecanoylphorbol Acetate | 1984 |
Phorbol ester-induced threonine phosphorylation of the human epidermal growth factor receptor occurs within the EGF binding domain.
Topics: Binding Sites; Cell Line; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Humans; Models, Biological; Neoplasms; Peptide Fragments; Phorbols; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Threonine; Trypsin | 1984 |
Effects of 12-O-tetradecanoyl phorbol-13-acetate and epidermal growth factor on the proliferation of human mutant fibroblasts in vitro.
Topics: Cell Division; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fibroblasts; Humans; Multiple Endocrine Neoplasia; Mutation; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Modulation of peptide binding to specific receptors on rat pituitary cells by tumor-promoting phorbol esters: decreased binding of thyrotropin-releasing hormone and somatostatin as well as epidermal growth factor.
Topics: Animals; Cell Line; Cell Membrane; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Kinetics; Phorbols; Pituitary Gland; Rats; Receptors, Cell Surface; Receptors, Somatostatin; Receptors, Thyrotropin-Releasing Hormone; Somatostatin; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1982 |
Inhibition of induced differentiation of C3H/10T 1/2 clone 8 mouse embryo cells by tumor promoters.
Topics: Animals; Antipain; Azacitidine; Cell Differentiation; Clone Cells; Embryo, Mammalian; Epidermal Growth Factor; Mice; Muscles; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Child; Cholera Toxin; Epidermal Growth Factor; Female; Fetus; Humans; Hydrocortisone; Keratins; Male; Mice; Phorbols; Pregnancy; Simian virus 40; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 1983 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin: examination of biochemical effects involved in the proliferation and differentiation of XB cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Cycle; Cell Differentiation; Cells, Cultured; Cholera Toxin; Cyclic AMP; Dioxins; Epidermal Growth Factor; Keratins; Mice; Phospholipids; Polychlorinated Dibenzodioxins; Tetradecanoylphorbol Acetate | 1984 |
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.
Topics: Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Kinetics; Male; Phorbols; Phosphorylation; Phosphotyrosine; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on fibroblasts from individuals genetically predisposed to cancer.
Topics: Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cytoskeleton; Disease Susceptibility; Down Syndrome; Epidermal Growth Factor; Fanconi Anemia; Female; Fibroblasts; Humans; Intestinal Polyps; Male; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Trypsin; Xeroderma Pigmentosum | 1982 |
Activation of calcium and phospholipid-dependent protein kinase by epidermal growth factor (EGF) in A431 cells: attenuation by 12-0-tetradecanoylphorbol-13-acetate (TPA).
Topics: Carcinoma, Squamous Cell; Cell Line; Diglycerides; Drug Antagonism; Epidermal Growth Factor; Humans; Kinetics; Phorbols; Phospholipids; Protein Kinase C; Protein Kinases; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin.
Topics: Amyloid beta-Protein Precursor; Carrier Proteins; Cells, Cultured; Epidermal Growth Factor; Fibrinolysin; Fibroblasts; Humans; Mitogens; Phorbols; Plasminogen Activators; Plasminogen Inactivators; Protease Nexins; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thrombin | 1983 |
Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA.
Topics: Animals; Cell Line; Cell Transformation, Viral; Epidermal Growth Factor; Glycoproteins; Kirsten murine sarcoma virus; Mice; Phorbols; Protein Biosynthesis; RNA, Messenger; Sarcoma Viruses, Murine; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Retinoids specifically enhance the number of epidermal growth factor receptors.
Topics: Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Peptides; Receptor, Insulin; Receptors, Cell Surface; Receptors, Concanavalin A; Retinol-Binding Proteins; Stereoisomerism; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1980 |
Changes in epidermal growth factor receptors associated with adenovirus transformation, chemical carcinogen transformation and exposure to a phorbol ester tumor promoter.
Topics: Adenoviruses, Human; Animals; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Epidermal Growth Factor; Mice; Peptides; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1980 |
Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.
Topics: Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Colchicine; Cytochalasin B; Epidermal Growth Factor; Griseofulvin; Melitten; Mutagens; Podophyllotoxin; Polyomavirus; Tetradecanoylphorbol Acetate; Vinblastine | 1980 |
Teleocidin B inhibits binding of epidermal growth factor to cellular receptors probably by the same mechanism as phorbol esters.
Topics: Alkaloids; Animals; Cell Division; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Indoles; Kinetics; Liver Neoplasms, Experimental; Lyngbya Toxins; Peptides; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1980 |
Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors.
Topics: Alkaloids; Animals; Arachidonic Acids; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Epidermal Growth Factor; ErbB Receptors; Kinetics; Lyngbya Toxins; Mice; Phorbols; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1981 |
Inhibition of epidermal growth factor binding to mouse embryonal carcinoma cells by phorbol esters mediated by specific phorbol ester receptors.
Topics: Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Neoplasms, Experimental; Peptides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Teratoma; Tetradecanoylphorbol Acetate | 1981 |
Specific binding of transforming growth factor correlates with promotion of anchorage independence in EGF receptorless mouse JB6 cells.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Peptides; Receptors, Cell Surface; Skin; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1981 |
Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.
Topics: Carcinoma; Cell Line; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Freezing; Humans; Kinetics; Macromolecular Substances; Mouth Neoplasms; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Interaction of tumor promoters and growth factors with cultured cells.
Topics: Animals; Cell Line; Cells, Cultured; DNA; Drug Synergism; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblasts; Kinetics; Mice; Phorbols; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of epidermal growth factor binding by phorbol esters, saccharin, and cyclamate and its implications in the mechanism of tumor promotion.
Topics: Carcinogens; Cocarcinogenesis; Cyclamates; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Phorbols; Receptors, Cell Surface; Saccharin; Structure-Activity Relationship; Temperature; Tetradecanoylphorbol Acetate | 1982 |
Effects of retinoic acid on the binding and mitogenic activity of epidermal growth factor.
Topics: Animals; Cell Division; Cell Line; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Insulin; Mice; Mitogens; Peptides; Receptors, Cell Surface; Temperature; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tretinoin | 1982 |
Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Clone Cells; Drug Resistance; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin; Tetradecanoylphorbol Acetate | 1982 |
Effect of retinoic acid and 12-O-tetradecanoyl phorbol-13-acetate on the binding of epidermal growth factor to its cellular receptors.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred C3H; Phorbols; Receptors, Cell Surface; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1982 |
Epidermal growth factor and phorbol ester actions on human osteosarcoma cells. Characterization of response and nonresponsive cell lines.
Topics: Calcium; Cell Line; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Humans; Osteosarcoma; Phorbol Esters; Phorbols; Prostaglandins E; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1982 |
Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism.
Topics: Alkaloids; Animals; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Kinetics; Lactones; Lyngbya Toxins; Marine Toxins; Mice; Mollusk Venoms; Phorbols; Phospholipids; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Drug; Tetradecanoylphorbol Acetate | 1983 |
Binding of phorbol dibutyrate and epidermal growth factor to cultured human epidermal cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production.
Topics: Animals; Calcium; Cell Line; Cyclic AMP; Epidermal Growth Factor; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1983 |
Tumor promoter 12-O-tetradecanoylphorbol 13-acetate, like epidermal growth factor, stimulates cell proliferation and inhibits differentiation of mouse mammary epithelial cells in culture.
Topics: Animals; Caseins; Cell Differentiation; Cell Division; Cells, Cultured; DNA; Epidermal Growth Factor; Female; Mammary Glands, Animal; Mice; Phorbols; Prolactin; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
Teleocidin is not mitogenic for 12-O-tetradecanoylphorbol-13-acetate non-proliferative variants of 3T3 cells.
Topics: Alkaloids; Animals; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Genetic Variation; Lyngbya Toxins; Mice; Phorbols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
Biological action of epidermal growth factor and its functional receptors in normal mammary epithelial cells.
Topics: Animals; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Lactation; Mammary Glands, Animal; Mice; Pregnancy; Receptors, Cell Surface; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Simultaneous visualization of the binding of nerve growth factor and epidermal growth factor to single rat pheochromocytoma (PC12) cells through indirect immunohistofluorescence.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Clone Cells; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; Nerve Growth Factors; Pheochromocytoma; Rats; Receptors, Cell Surface; Receptors, Nerve Growth Factor; Tetradecanoylphorbol Acetate | 1982 |
Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Line; Diglycerides; Epidermal Growth Factor; ErbB Receptors; Humans; Phorbol Esters; Phorbols; Phosphatidylinositols; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1983 |
Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.
Topics: Carcinogens; Carcinoma, Squamous Cell; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1984 |
Retinoic acid-induced changes in epidermal growth factor binding and in biological responses mediated by phorbol ester tumor promoter.
Topics: Animals; Carrier Proteins; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Mice; Ornithine Decarboxylase; Phorbols; Rats; Receptors, Retinoic Acid; Temperature; Tetradecanoylphorbol Acetate; Tretinoin | 1984 |
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.
Topics: Adenosine Triphosphate; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Molecular Weight; Peptide Fragments; Phorbols; Phosphorus Radioisotopes; Phosphorylation; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Tyrosine | 1984 |
Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred Strains; Phorbols; Receptors, Cell Surface; Skin; Skin Neoplasms; Skin Physiological Phenomena; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line; Clone Cells; Cloning, Molecular; DNA Restriction Enzymes; Epidermal Growth Factor; Genes; Genetic Vectors; Growth Hormone; Humans; Phorbols; Prolactin; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1984 |
Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.
Topics: Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Epidermal Growth Factor; ErbB Receptors; Humans; Kinetics; Phorbols; Phosphorylation; Receptors, Cell Surface; Succinimides; Tetradecanoylphorbol Acetate | 1984 |
Effects of biological response modifiers on plasminogen activator activity in epidermal cell culture.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP; DNA; Epidermal Growth Factor; Mice; Mitosis; Plasminogen Activators; Skin; Tetradecanoylphorbol Acetate; Triamcinolone Acetonide | 1984 |
Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised extracellular magnesium induce proliferation of chicken heart mesenchymal cells.
Topics: Animals; Cell Division; Cells, Cultured; Chickens; Epidermal Growth Factor; Ethers; Heart; Ionomycin; Magnesium; Myocardium; Ouabain; Phorbols; Protein Kinases; Tetradecanoylphorbol Acetate | 1984 |
Exogenous Cu,Zn-superoxide dismutase suppresses the stimulation of neonatal rat hepatocytes' growth by tumor promoters.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Cells, Cultured; Copper; DNA; Epidermal Growth Factor; Female; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Zinc | 1984 |
Effects of nickel sulfate on growth and differentiation of normal human bronchial epithelial cells.
Topics: Bronchi; Cell Division; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelium; Humans; In Vitro Techniques; Nickel; Tetradecanoylphorbol Acetate | 1984 |
Mitogenic hormones and tumor promoters greatly increase the incidence of colony-forming cells bearing amplified dihydrofolate reductase genes.
Topics: Animals; Arginine Vasopressin; Carcinogens; Cells, Cultured; Clone Cells; Drug Resistance; Epidermal Growth Factor; Gene Amplification; Genes; Hormones; Insulin; Methotrexate; Mice; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1983 |
Some mitogens cause rapid increases in free calcium in fibroblasts.
Topics: Aminoquinolines; Animals; Calcium; Cell Line; Dinoprost; Epidermal Growth Factor; Fibroblasts; Insulin; Mice; Mitogens; Prostaglandins F; Tetradecanoylphorbol Acetate; Vasopressins | 1984 |
Stimulation of human chorionic gonadotropin and progesterone secretion by tumor promoters, phorbol ester and teleocidin B, in cultured choriocarcinoma cells.
Topics: Alkaloids; Animals; Carcinogens; Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Epidermal Growth Factor; Female; Humans; Kinetics; Lyngbya Toxins; Male; Mice; Phorbols; Pregnancy; Progesterone; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 1983 |
Ca2+-dependent stimulation of hexose transport by A23187, 12-O-tetradecanoylphorbol-13-acetate and epidermal growth factor in mouse fibroblasts.
Topics: Animals; Biological Transport, Active; Calcimycin; Calcium; Deoxy Sugars; Deoxyglucose; Egtazic Acid; Epidermal Growth Factor; Fibroblasts; Mice; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Role of polyamine synthesis in the stimulation of hexose transport by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate in cultured mouse fibroblasts.
Topics: Animals; Cells, Cultured; Deoxyglucose; Eflornithine; Epidermal Growth Factor; Fibroblasts; Hexoses; Mice; Ornithine; Polyamines; Putrescine; Tetradecanoylphorbol Acetate | 1984 |
A comparison of the effects of tumor promoters 12-O-tetradecanoylphorbol-13-acetate and teleocidin on gene expression in human skin cell fibroblasts.
Topics: Autoradiography; Carcinogens; Cell Differentiation; Child; Epidermal Growth Factor; Female; Fibroblasts; Gene Expression Regulation; Humans; Lyngbya Toxins; Male; Middle Aged; Phorbols; Protein Biosynthesis; Skin; Tetradecanoylphorbol Acetate | 1984 |
Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcitriol; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Epidermal Growth Factor; Kinetics; Osteoblasts; Parathyroid Hormone; Prostaglandins; Tetradecanoylphorbol Acetate; Thrombin; Tritium | 1984 |
Membrane-mediated responses to 12-O-tetradecanoylphorbol-13-acetate in human skin fibroblasts.
Topics: Carcinogens; Cell Membrane; Cells, Cultured; Child; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Female; Fetus; Fibroblasts; Humans; Kinetics; Lyngbya Toxins; Male; Membrane Proteins; Middle Aged; Molecular Weight; Peptide Fragments; Phorbols; Pregnancy; Skin; Tetradecanoylphorbol Acetate | 1984 |
EGF growth promoting activity is neutralized by phorbol esters.
Topics: Cell Division; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factors; Fibroblasts; Growth Inhibitors; Humans; Insulin; Mitogens; Peptides; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: induction of competence or incomplete removal?
Topics: Animals; Blood Platelets; Cell Cycle; Cell Division; DNA; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; Insulin; Mice; Mitogens; Peptides; Phorbols; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Relationship between mezerein-mediated biological responses and phorbol ester receptor occupancy.
Topics: Binding, Competitive; Caenorhabditis elegans Proteins; Carrier Proteins; Dinoprostone; Diterpenes; Epidermal Growth Factor; Humans; Kinetics; Osteosarcoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Prostaglandins E; Protein Kinase C; Receptors, Drug; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
The effect of fluocinolone acetonide and 12-O-tetradecanoyl-phorbol-13-acetate on the binding and biological activity of epidermal growth factor in rat fibroblasts.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; DNA Replication; Epidermal Growth Factor; Fibroblasts; Fluocinolone Acetonide; Ornithine Decarboxylase; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1983 |
Plasminogen activator in cultured human epidermal cells.
Topics: Cells, Cultured; Cholera Toxin; Colchicine; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epidermis; Humans; Hydrolysis; Plasminogen; Plasminogen Activators; Tetradecanoylphorbol Acetate | 1983 |
The growth of cultured human foreskin keratinocytes is not stimulated by a tumor promoter.
Topics: Cell Division; Cells, Cultured; Epidermal Growth Factor; Humans; Male; Ornithine Decarboxylase; Phorbols; Skin; Tetradecanoylphorbol Acetate | 1984 |
Alteration of the chemotactic response of NIH/3T3 cells to PDGF by growth factors, transformation, and tumor promoters.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemotaxis; Epidermal Growth Factor; Epithelium; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Kirsten murine sarcoma virus; Mice; Phorbols; Platelet-Derived Growth Factor; Tetradecanoylphorbol Acetate | 1984 |
Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms.
Topics: Alkaloids; Animals; Carcinogens; Cell Adhesion; Cells, Cultured; Clone Cells; Culture Media; DNA; Epidermal Growth Factor; Fibroblasts; Kinetics; Lyngbya Toxins; Mice; Mice, Inbred C3H; Palmitoylcarnitine; Phorbols; Tetradecanoylphorbol Acetate | 1984 |
Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Diterpenes; Epidermal Growth Factor; Gangliosides; Glucosamine; Mice; Phorbol Esters; Phorbols; Skin; Terpenes; Tetradecanoylphorbol Acetate | 1984 |
Modulation of phagocytosis by tumor promoters and epidermal growth factor in normal and transformed macrophages.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Diterpenes; Epidermal Growth Factor; Erythrocytes; Female; In Vitro Techniques; Macrophages; Mice; Microscopy, Electron, Scanning; Peptides; Phagocytosis; Phorbols; Pyran Copolymer; Tetradecanoylphorbol Acetate; Thioglycolates | 1980 |
Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Monoiodotyrosine; Peptides; Phorbols; Protein Binding; Rats; Receptors, Drug; Temperature; Tetradecanoylphorbol Acetate | 1980 |
Growth arrest of AKR-2B cells maintained in the presence of epidermal growth factor or 12-O-tetradecanoylphorbol-13 acetate: evidence for two separate G1 arrest points.
Topics: Amanitins; Cell Line; Culture Media; DNA; Epidermal Growth Factor; Mitosis; Peptides; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Retinoids block ornithine decarboxylase induction in cells treated with the tumor promotor TPA or the peptide growth hormones, EGF and SGF.
Topics: Animals; Carboxy-Lyases; Cell Line; Enzyme Induction; Epidermal Growth Factor; Growth Inhibitors; Kidney; Ornithine Decarboxylase; Phorbols; Rats; Sarcoma, Experimental; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1980 |
Tumor promoter modulation of epidermal growth factor- and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cells.
Topics: Animals; Binding Sites; Cell Adhesion; Cell Line; Epidermal Growth Factor; Microvilli; Nerve Growth Factors; Peptides; Pheochromocytoma; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1980 |
Variants of 3T3 cells lacking mitogenic response to the tumor promoter tetradecanoyl-phorbol-acetate.
Topics: Animals; Cell Count; Cell Line; Clone Cells; DNA Replication; Embryo, Mammalian; Epidermal Growth Factor; Genetic Variation; Mice; Mitogens; Mitosis; Phorbols; Tetradecanoylphorbol Acetate | 1981 |
Calmodulin inhibitors modify cell surface changes triggered by a tumor promoter.
Topics: Animals; Calcium-Binding Proteins; Calmodulin; Cell Line; Cell Membrane; Choline; Epidermal Growth Factor; Epidermis; HeLa Cells; Humans; Membrane Lipids; Mice; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate; Trifluoperazine | 1981 |
Tumor promoter-induced inhibition of epidermal growth factor binding to cultured mouse primary epidermal cells.
Topics: Animals; Calcium; Cells, Cultured; Epidermal Growth Factor; Hyperplasia; Mice; Peptides; Phorbol Esters; Phorbols; Skin; Temperature; Tetradecanoylphorbol Acetate | 1981 |
Growth stimulation of hamster embryonic fibroblasts by phorbol esters.
Topics: Animals; Cell Division; Cells, Cultured; Cricetinae; Culture Media; Deoxyglucose; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; Mesocricetus; Phorbols; Tetradecanoylphorbol Acetate | 1980 |
Promotion of x-ray transformation in vitro.
Topics: Animals; Anti-Inflammatory Agents; Cell Count; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA Repair; Epidermal Growth Factor; Mice; Mitomycins; Mutation; Phorbols; Radiation, Ionizing; Tetradecanoylphorbol Acetate; X-Rays | 1982 |
Studies on antagonistic actions of TPA and retinoic acid.
Topics: Animals; Cell Adhesion; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Contact Inhibition; Epidermal Growth Factor; Mice; Phorbols; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
An effect of fibronectin in epidermal growth factor (EGF)-stimulated membrane protein phosphorylation in human carcinoma cells.
Topics: Carcinoma; Cells, Cultured; Epidermal Growth Factor; Fibronectins; Humans; Membrane Proteins; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Urea | 1982 |
Effects of 12-0-Tetradecanoylphorbol-13-acetate (TPA) on rat pheochromocytoma (PC12) cells: interactions with epidermal growth factor and nerve growth factor.
Topics: Animals; Cell Differentiation; Cell Line; Choline; Drug Interactions; Enzyme Induction; Epidermal Growth Factor; Nerve Growth Factors; Neurons; Ornithine Decarboxylase; Pheochromocytoma; Phorbols; Phosphates; Phosphorylation; Proteins; Rats; Tetradecanoylphorbol Acetate | 1982 |
Nutrition of prostate cells.
Topics: Adenocarcinoma; Calcium; Cell Division; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Humans; Hydrocortisone; Insulin; Male; Prostate; Prostatic Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
On deciding which factors regulate cell growth.
Topics: Animals; Caffeine; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cycloheximide; Epidermal Growth Factor; Humans; Insulin; Kinetics; Lectins; Mutation; Tetradecanoylphorbol Acetate; Thrombin | 1981 |
Hexose transport in undifferentiated and differentiated BALB/c 3T3 preadipose cells: effects 12-O-tetradecanoylphorbol-13-acetate and insulin.
Topics: 3-O-Methylglucose; Adipose Tissue; Animals; Biological Transport, Active; Cell Differentiation; Cells, Cultured; Deoxyglucose; Epidermal Growth Factor; Glucose; Insulin; Kinetics; Methylglucosides; Mice; Mice, Inbred BALB C; Phorbols; Tetradecanoylphorbol Acetate | 1982 |
Growth factor-induced actin reorganization in Swiss 3T3 cells.
Topics: 3T3 Cells; Actins; Animals; Becaplermin; Bombesin; Bradykinin; Cattle; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fibronectins; Growth Substances; Humans; Mice; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Recombinant Proteins; Swine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vitronectin | 1995 |
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line, Transformed; Cinnamates; Dinoprostone; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Isoquinolines; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Protein kinase C mediates short- and long-term effects on receptor tyrosine kinases. Regulation of tyrosine phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Homeostasis; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1995 |
Hepatoma cell-specific expression of a retrovirally transferred gene is achieved by alpha-fetoprotein but not insulinlike growth factor II regulatory sequences.
Topics: 3T3 Cells; alpha-Fetoproteins; Animals; beta-Galactosidase; Blotting, Northern; Carcinoma, Hepatocellular; DNA; Epidermal Growth Factor; Gene Expression; Gene Transfer Techniques; HeLa Cells; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Mice; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; Retroviridae; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.
Topics: 3T3 Cells; Animals; Cell Line; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Sodium Fluoride; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1994 |
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenosine Triphosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; Genes, ras; Kinetics; Phosphoproteins; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Tyrosine | 1994 |
Epidermal growth factor induces acrosomal exocytosis in bovine sperm.
Topics: Acrosome; Animals; Bucladesine; Calcimycin; Calcium; Cattle; Epidermal Growth Factor; ErbB Receptors; Exocytosis; Male; Phosphotyrosine; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Lysophosphatidylcholine transcriptionally induces growth factor gene expression in cultured human endothelial cells.
Topics: Bacterial Toxins; Blotting, Northern; Cell Adhesion Molecules; Cell Nucleus; Cells, Cultured; Dactinomycin; Dose-Response Relationship, Drug; E-Selectin; Endothelium, Vascular; Epidermal Growth Factor; Gene Expression; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Adhesion Molecule-1; Intercellular Signaling Peptides and Proteins; Interleukin-6; Interleukin-8; Lysophosphatidylcholines; Macromolecular Substances; Platelet-Derived Growth Factor; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins | 1994 |
K252a potentiates epidermal growth factor-induced differentiation of PC12 cells.
Topics: Animals; Blotting, Northern; Blotting, Western; Carbazoles; Cell Differentiation; Epidermal Growth Factor; Gene Expression Regulation; Humans; Indole Alkaloids; Mice; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Mas; Receptors, Nerve Growth Factor; RNA; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Contribution of known mitogenic signaling pathways to induction of DNA synthesis in quiescent Chinese hamster fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Cholera Toxin; Cricetinae; Cricetulus; Cyclic AMP; Epidermal Growth Factor; Fibroblasts; Insulin; Mitosis; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Ribosomal Protein S6; Ribosomal Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Theophylline | 1994 |
Cross talk of tumor necrosis factor-alpha and epidermal growth factor in human microvascular endothelial cells.
Topics: Base Sequence; Endothelium, Vascular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Genes, fos; Humans; Microcirculation; Molecular Sequence Data; Nuclear Proteins; Omentum; Peptide Mapping; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyrosine | 1994 |
Epidermal growth factor induces PC12 cell differentiation in the presence of the protein kinase inhibitor K-252a.
Topics: Animals; Carbazoles; Cell Differentiation; Choline O-Acetyltransferase; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Immunoblotting; Indole Alkaloids; Nerve Growth Factors; Neurites; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
Topics: Cell Adhesion; Cell Line; Cell Movement; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Genistein; Glycoproteins; Humans; Insulin-Like Growth Factor I; Integrins; Isoflavones; Kinetics; Naphthalenes; Nitriles; Pancreatic Neoplasms; Phosphotyrosine; Polycyclic Compounds; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Receptor, IGF Type 1; Receptors, Vitronectin; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Vitronectin | 1994 |
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Topics: Alkaloids; Arachidonate 12-Lipoxygenase; Carcinoma, Squamous Cell; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Humans; Naphthalenes; Phosphatidylinositol Phosphates; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Ceramides; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Gingiva; Humans; In Vitro Techniques; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphothreonine; Phosphotyrosine; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sphingosine; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1994 |
Induction of hepatocyte growth factor in human skin fibroblasts by epidermal growth factor, platelet-derived growth factor and fibroblast growth factor.
Topics: Blotting, Northern; Cells, Cultured; Dexamethasone; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblasts; Gene Expression; Hepatocyte Growth Factor; Humans; Infant; Kinetics; Platelet-Derived Growth Factor; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1994 |
Evidence that the bradykinin-induced activation of phospholipase D and of the mitogen-activated protein kinase cascade involve different protein kinase C isoforms.
Topics: Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Glyceryl Ethers; Humans; Isoenzymes; Kinetics; Myelin Basic Protein; Phospholipase D; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Skin; Tetradecanoylphorbol Acetate; Zellweger Syndrome | 1995 |
Insulin-like growth factor binding protein production in human follicular thyroid carcinoma cells.
Topics: Adenocarcinoma, Follicular; Blotting, Northern; Carrier Proteins; Colforsin; Endopeptidases; Epidermal Growth Factor; Humans; Immunosorbent Techniques; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tumor Cells, Cultured | 1995 |
Protein kinase C-dependent regulation of L-arginine transport activity in Caco-2 intestinal cells.
Topics: Alkaloids; Arginine; Benzophenanthridines; Biological Transport; Caco-2 Cells; Carrier Proteins; Cell Differentiation; Cycloheximide; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Kinetics; Membrane Glycoproteins; Membrane Proteins; Phenanthridines; Protein Kinase C; Receptors, Virus; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Up-Regulation | 1995 |
The myristoylated alanine-rich C-kinase substrate (MARCKS) is not required for mitogenic signalling via protein kinase C in cultured rat intestinal epithelial (RIE-1) cells.
Topics: 3T3 Cells; Angiotensin II; Animals; Antibodies; Cattle; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Epithelial Cells; Epithelium; Gene Expression; Immunoblotting; Intestinal Mucosa; Intestines; Intracellular Signaling Peptides and Proteins; Iodine Radioisotopes; Membrane Proteins; Mice; Mitogens; Mitosis; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C; Proteins; Rabbits; Rats; RNA, Messenger; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1995 |
Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Hepatocyte Growth Factor; Liver; Male; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Chlorocebus aethiops; Diphtheria Toxin; DNA; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Macrolides; Molecular Weight; Piperazines; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Staurosporine; Tetradecanoylphorbol Acetate; Vero Cells | 1995 |
Intercellular heterogeneity of early mitogenic events: cAMP generalizes the EGF effect on c-Fos protein appearance but not on MAP kinase phosphorylation and nuclear translocation in dog thyroid epithelial cells.
Topics: Animals; Biological Transport; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Cycle; Cell Nucleus; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Epidermal Growth Factor; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Hepatocyte Growth Factor; Mitogens; Phosphorylation; Proto-Oncogene Proteins c-fos; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
A kinase associated with chromatin that can be activated by ligand-p185c-Neu or epidermal growth factor-receptor interactions.
Topics: Animals; Cell Line; Cell Nucleus; Chromatin; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Ethers, Cyclic; Growth Substances; Ligands; Mice; Molecular Weight; Okadaic Acid; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Receptor, ErbB-2; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor alpha | 1995 |
Prostaglandin F2 alpha inhibits epidermal growth factor binding to cellular receptors on adipocyte precursors in primary culture.
Topics: Adipose Tissue; Animals; Cells, Cultured; Dinoprost; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Kinetics; Prostaglandin D2; Protein Kinase C; Rats; Stem Cells; Tetradecanoylphorbol Acetate | 1995 |
Role of extracellular calcium influx in EGF-induced osteoblastic cell proliferation.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; Fura-2; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Osteoblasts; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1995 |
Protein kinase C-dependent down-regulation of basic fibroblast growth factor (FGF-2) receptor by phorbol ester and epidermal growth factor in porcine granulosa cells.
Topics: Animals; Cell Differentiation; Cell Division; Down-Regulation; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Granulosa Cells; Isoenzymes; Protein Kinase C; Receptors, Fibroblast Growth Factor; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate | 1995 |
Involvement of protein kinase C in the control of tRNA modification with queuine in HeLa cells.
Topics: Anticodon; Blood; Culture Media; Enzyme Reactivators; Epidermal Growth Factor; Guanine; HeLa Cells; Humans; Kinetics; Oxygen; Pentosyltransferases; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Transfer; Tetradecanoylphorbol Acetate | 1995 |
Rapid and long-term effects on protein kinase C on receptor tyrosine kinase phosphorylation and degradation.
Topics: 3T3 Cells; Animals; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Receptor Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1995 |
Transcriptional and post-transcriptional regulation of the receptor for urokinase-type plasminogen activator by cytokines and tumour promoters in the human lung carcinoma cell line A549.
Topics: Carcinogens; Cell Membrane; Cytokines; Enzyme Activation; Epidermal Growth Factor; Humans; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA Processing, Post-Transcriptional; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1995 |
Synthesis and phosphorylation of osteopontin by avian epiphyseal growth-plate chondrocytes as affected by differentiation.
Topics: Alkaline Phosphatase; Amino Acid Sequence; Animals; Ascorbic Acid; Blotting, Northern; Bone Development; Cell Differentiation; Cell Division; Cells, Cultured; Chickens; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Growth Plate; In Situ Hybridization; Molecular Sequence Data; Osteopontin; Parathyroid Hormone; Phosphoproteins; Phosphorylation; RNA, Messenger; Sialoglycoproteins; Tetradecanoylphorbol Acetate; Tibia | 1995 |
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
Topics: Adenylate Cyclase Toxin; Animals; Cell Line; Cholera Toxin; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Lysophospholipids; Pertussis Toxin; Phosphates; Phosphotyrosine; Proto-Oncogene Proteins p21(ras); Receptors, Cell Surface; Receptors, Thrombin; Signal Transduction; Suramin; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Monoclonal; Antibody Specificity; Cells, Cultured; Colforsin; Diacylglycerol Kinase; Epidermal Growth Factor; Epitopes; ErbB Receptors; Escherichia coli; Humans; Peptide Mapping; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotransferases; Phosphotyrosine; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 1993 |
Thrombin Ca(2+)-dependently stimulates protein tyrosine phosphorylation in BC3H1 muscle cells.
Topics: Animals; Calcimycin; Calcium; Cell Line; Egtazic Acid; Epidermal Growth Factor; Immunoblotting; Insulin; Kinetics; Mice; Muscles; Pertussis Toxin; Phosphorylation; Phosphotyrosine; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine; Virulence Factors, Bordetella | 1993 |
Activation of protein kinase C increases Ca2+ sensitivity of secretory response of GH3 pituitary cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Kinetics; Pituitary Neoplasms; Potassium Chloride; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1993 |
Effects of epidermal growth factor versus phorbol ester on kidney epithelial (LLC-PK1) tight junction permeability and cell division.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Line; Cell Membrane Permeability; Electric Conductivity; Electric Impedance; Epidermal Growth Factor; Epithelial Cells; Epithelium; Intercellular Junctions; Kidney; Microscopy, Electron; Rats; Ruthenium Red; Tetradecanoylphorbol Acetate | 1993 |
Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromatography, Ion Exchange; Enzyme Activation; Epidermal Growth Factor; Heparin; Immunoblotting; Kinetics; Muscle, Smooth, Vascular; Myelin Basic Protein; Protein Kinase Inhibitors; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
Stimulation of tyrosine phosphorylation and mitogen-activated-protein (MAP) kinase activity in human SH-SY5Y neuroblastoma cells by carbachol.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Enzyme Activation; Epidermal Growth Factor; Humans; Neuroblastoma; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Kinases; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine | 1993 |
Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Line, Transformed; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Humans; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Oncogene Proteins v-sis; Oncogenes; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Retroviridae Proteins, Oncogenic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 1995 |
Modulation of epidermal growth factor receptor interaction with the detergent-insoluble cytoskeleton and its effects on receptor tyrosine kinase activity.
Topics: Analysis of Variance; Cell Fractionation; Cell Line; Cytoskeleton; Detergents; Epidermal Growth Factor; ErbB Receptors; Humans; Immunoblotting; Kinetics; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Regulation of casein kinase II by growth factors: a reevaluation.
Topics: Amino Acid Sequence; Animals; Bombesin; Carcinoma, Squamous Cell; Casein Kinase II; Cattle; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Induction; Epidermal Growth Factor; Fetal Blood; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Humans; Insulin; Ionomycin; Lung; Molecular Sequence Data; Neoplasm Proteins; Peptide Fragments; Phosphorylation; Platelet-Derived Growth Factor; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Translational regulation of the mammalian growth-related protein P23: involvement of eIF-4E.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies; Biomarkers, Tumor; Blotting, Western; Bucladesine; Carcinoma, Ehrlich Tumor; Cell Division; Epidermal Growth Factor; Eukaryotic Initiation Factor-4E; Fibroblasts; Gene Expression Regulation; Growth Substances; HeLa Cells; Hot Temperature; Humans; Insulin; Methionine; Mice; Molecular Sequence Data; Neoplasm Proteins; Peptide Initiation Factors; Peptides; Phosphorylation; Protein Biosynthesis; Rabbits; Recombinant Proteins; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Protein, Translationally-Controlled 1 | 1994 |
delta-Iodolactones decrease epidermal growth factor-induced proliferation and inositol-1,4,5-trisphosphate generation in porcine thyroid follicles--a possible mechanism of growth inhibition by iodide.
Topics: Animals; Arachidonic Acids; Cell Division; Cyclic AMP; Epidermal Growth Factor; Homeostasis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Iodides; Kinetics; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
Human placental endothelin: expression of endothelin-1 mRNA by human placental fibroblasts in culture.
Topics: Blotting, Northern; Cells, Cultured; Endothelin-1; Endothelins; Epidermal Growth Factor; Female; Fibroblasts; Gene Expression; Gene Expression Regulation; Humans; Interleukin-1; Placenta; Pregnancy; Protein Precursors; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Trophoblasts | 1995 |
Mutual antagonistic interactions between the thyrotropin (adenosine 3',5'-monophosphate) and protein kinase C/epidermal growth factor (tyrosine kinase) pathways in cell proliferation and differentiation of cultured human thyroid follicles.
Topics: Alkaloids; Cell Differentiation; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Epidermal Growth Factor; Humans; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein-Tyrosine Kinases; Second Messenger Systems; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
The epidermal growth factor mitogenic signal is modulated by protein kinase C in T51B rat liver cells.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cells, Cultured; DNA; DNA Replication; Down-Regulation; Epidermal Growth Factor; Liver; Protein Kinase C; Rats; Rats, Inbred F344; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
EGF-mediated phosphorylation of extracellular signal-regulated kinases in osteoblastic cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Osteosarcoma; Phosphorylation; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Changes in oncogene mRNA expression during human keratinocyte differentiation.
Topics: Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; Gene Expression Regulation; Genes, jun; Genes, myc; Genes, ras; Humans; Keratinocytes; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Tonic modulation of dog thyrocyte H2O2 generation and I- uptake by thyrotropin through the cyclic adenosine 3',5'-monophosphate cascade.
Topics: Animals; Cell Differentiation; Cyclic AMP; Dogs; Epidermal Growth Factor; Hydrogen Peroxide; Iodides; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1995 |
Stimulation of mitogen-activated protein kinase by thyrotropin in astrocytes.
Topics: Animals; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factor 2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thyrotropin | 1995 |
Induction of c-fos in pituitary cells by thyrotrophin-releasing hormone and phorbol 12-myristate 13-acetate depends upon Ca2+ influx.
Topics: Alkaloids; Animals; Calcium; Cell Line; Culture Media, Serum-Free; Cytoplasm; Down-Regulation; Edetic Acid; Egtazic Acid; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Phorbol 12,13-Dibutyrate; Pituitary Gland; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1994 |
Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival factors for MDA-231 cells exposed to adriamycin.
Topics: Adenosine Triphosphate; Apoptosis; Aurintricarboxylic Acid; Breast Neoplasms; Cell Survival; Cycloheximide; DNA, Neoplasm; Doxorubicin; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; L-Lactate Dehydrogenase; Microscopy, Electron; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
erbB-2 expression in estrogen-receptor-positive breast-tumor cells is regulated by growth-modulatory reagents.
Topics: Base Sequence; Breast Neoplasms; Bucladesine; Cell Count; Epidermal Growth Factor; ErbB Receptors; Estradiol; Gene Expression; Growth Substances; Humans; Insulin; Molecular Sequence Data; Progesterone; Prolactin; Promoter Regions, Genetic; Proto-Oncogene Proteins; Receptor, ErbB-2; Receptors, Estrogen; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tretinoin; Tumor Cells, Cultured | 1994 |
Preferential primary-response gene expression in promotion-resistant versus promotion-sensitive JB6 cells.
Topics: 3T3 Cells; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression; Genes; Immediate-Early Proteins; Mice; Mice, Inbred BALB C; Multigene Family; Proteins; Tetradecanoylphorbol Acetate; Tristetraprolin | 1994 |
A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes.
Topics: Amino Acid Sequence; Animals; Anisomycin; Cell Line; Epidermal Growth Factor; Genes, Immediate-Early; High Mobility Group Proteins; Mice; Mice, Inbred C3H; Micrococcal Nuclease; Mitogens; Molecular Sequence Data; Nucleosomes; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate | 1994 |
Jun B expression is regulated differently by three mitogenic pathways in thyrocytes.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Epidermal Growth Factor; Gene Expression Regulation; In Vitro Techniques; Mitosis; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Transcription, Genetic | 1994 |
Characterization of signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Epidermal Growth Factor; Genistein; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Biological Transport; Cell Compartmentation; Cell Division; Dose-Response Relationship, Drug; Epidermal Growth Factor; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Point Mutation; Protein Conformation; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Characterization of epidermal growth factor receptor in human endometrial cells in culture.
Topics: Cells, Cultured; Down-Regulation; Endometrium; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Protein Binding; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1994 |
Differential modulation of human fibroblast and keratinocyte growth by the protein kinase C inhibitor GF 109203X.
Topics: Adolescent; Adult; Blotting, Northern; Casein Kinase II; Cell Differentiation; Cell Division; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Female; Fibroblasts; Gene Expression; Genes, fos; Genes, jun; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Indoles; Keratinocytes; Maleimides; Middle Aged; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate | 1994 |
The epidermal growth factor receptor in the human endometrial adenocarcinoma cell line HEC-1-B.
Topics: Adenocarcinoma; Alkaloids; Binding Sites; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Humans; Kinetics; Progesterone; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effect of monensin on DNA synthesis in cultured human thyroid cells.
Topics: Cell Cycle; Cells, Cultured; DNA; Endocytosis; Epidermal Growth Factor; Flow Cytometry; Golgi Apparatus; Graves Disease; Humans; Insulin; Lysosomes; Monensin; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine; Thyroid Gland; Thyrotropin | 1993 |
Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; Estradiol; Guanine Nucleotide Exchange Factors; Mice; Mitosis; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); ras Guanine Nucleotide Exchange Factors; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade.
Topics: Animals; Blotting, Western; Cell Communication; Cell Line; Cells, Cultured; Connexin 43; Epidermal Growth Factor; Fluorescent Dyes; Gap Junctions; Isoquinolines; Liver; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Molecular Weight; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate | 1994 |
The role of protein kinase C in arachidonic acid release and prostaglandin E production from CHO cells transfected with EGF receptors.
Topics: Alkaloids; Animals; Arachidonic Acid; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Regulation of 17 beta-hydroxysteroid dehydrogenase type 1 by epidermal growth factor and transforming growth factor-alpha in choriocarcinoma cells.
Topics: 17-Hydroxysteroid Dehydrogenases; 8-Bromo Cyclic Adenosine Monophosphate; Catechols; Choriocarcinoma; Epidermal Growth Factor; Humans; Nitriles; Protein-Tyrosine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 1994 |
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators.
Topics: Alkaloids; Animals; Cell Line; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1994 |
Cytosolic phospholipase A2 gene expression in rat mesangial cells is regulated post-transcriptionally.
Topics: Animals; Base Sequence; Blood; Cells, Cultured; Cytosol; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Molecular Sequence Data; Phospholipases A; Phospholipases A2; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Epidermal growth factor counteracts insulin-induced expression of glucokinase in hepatocytes.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Gene Expression; Glucagon; Glucokinase; Glucosephosphate Dehydrogenase; Insulin; Insulin Antagonists; Kinetics; Liver; Male; Phospholipase D; Rats; Rats, Wistar; RNA, Messenger; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1994 |
Involvement of high-affinity binding site for EGF receptor in formation of rounding in A-431 epidermoid carcinoma cells.
Topics: Binding Sites; Carcinoma, Squamous Cell; Colforsin; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Kanamycin Kinase; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1994 |
Regulation of growth factor receptors on rat intestinal epithelial (RIE-1) cells by protein kinase C.
Topics: Angiotensin II; Animals; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Epithelium; ErbB Receptors; Hydrolysis; Intestines; Iodine Radioisotopes; Kinetics; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Rats; Receptors, Angiotensin; Receptors, Growth Factor; Tetradecanoylphorbol Acetate | 1994 |
Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts.
Topics: Animals; Blood; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Mitogens; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture.
Topics: Aromatase; Bucladesine; Cells, Cultured; Colforsin; Dehydroepiandrosterone; Epidermal Growth Factor; Female; Fibroblast Growth Factors; Granulosa Cells; Growth Substances; Humans; Insulin; Insulin-Like Growth Factor I; Luteal Cells; Progesterone; Steroid 17-alpha-Hydroxylase; Steroids; Tetradecanoylphorbol Acetate; Theca Cells; Transforming Growth Factor beta | 1994 |
Melittin inhibits epidermal growth factor-induced protein tyrosine phosphorylation: comparison with phorbol myristate acetate and calcium ionophore A23187.
Topics: 3T3 Cells; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Dimethyl Sulfoxide; Epidermal Growth Factor; Melitten; Mice; Phosphorylation; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Regulation of heparin binding-epidermal growth factor like growth factor gene expression by LDL and oxidized-LDL in rat mesangial cells.
Topics: Alkaloids; Animals; Blotting, Northern; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Heparin; Kinetics; Lipoproteins, LDL; Male; Oxidation-Reduction; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effects of epidermal growth factor on parathyroid hormone-related protein production by mammary epithelial cells.
Topics: Animals; Calcium; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Indomethacin; Lactation; Mammary Glands, Animal; Parathyroid Hormone-Related Protein; Prostaglandins; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Up-Regulation | 1994 |
Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer.
Topics: Blotting, Northern; Epidermal Growth Factor; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Pancreatic Neoplasms; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Biological Transport; Enzyme Activation; Epidermal Growth Factor; Glucose; Glycogen; Glycogen Synthase; Insulin; Kinetics; Mice; Molecular Sequence Data; Polyenes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 1994 |
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Humans; Mitogen-Activated Protein Kinase 1; Phosphorylation; Proline-Directed Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; Transcription Factor Pit-1; Transcription Factors; Transcription, Genetic; Ultraviolet Rays | 1994 |
Ras-dependent growth factor regulation of MEK kinase in PC12 cells.
Topics: Animals; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Genes, ras; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Rats; Tetradecanoylphorbol Acetate | 1994 |
Epidermal growth factor inhibits phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes in primary culture.
Topics: Animals; Bucladesine; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Gene Expression; Liver; Liver Neoplasms, Experimental; Male; Phosphoenolpyruvate Carboxykinase (GTP); Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrosine Transaminase | 1993 |
Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation.
Topics: Calcimycin; Catechols; Cells, Cultured; Dinoprostone; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Genistein; Humans; Isoflavones; Keratinocytes; Kinetics; Nitriles; Protein-Tyrosine Kinases; Signal Transduction; Skin; Tetradecanoylphorbol Acetate; Tyrphostins; Ultraviolet Rays | 1994 |
Expression of follistatin messenger ribonucleic acid in Sertoli cell-enriched cultures: regulation by epidermal growth factor and protein kinase C-dependent pathway but not by follicle-stimulating hormone and protein kinase A-dependent pathway.
Topics: Animals; Cattle; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Fetal Blood; Follicle Stimulating Hormone; Follistatin; Glycoproteins; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Tetradecanoylphorbol Acetate | 1993 |
T1 is a c-Fos- and FosB-responsive gene which is induced by growth factors through multiple signal transduction pathways.
Topics: 3T3 Cells; Animals; Becaplermin; Blotting, Northern; Blotting, Western; Cell Division; Cell Line; Cycloheximide; Epidermal Growth Factor; Estradiol; Gene Expression Regulation; Genes, fos; Glycoproteins; Growth Substances; Insulin; Mice; Mitosis; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-sis; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transferrin | 1994 |
Noradrenergic modulation of albumin expression in growth-stimulated adult rat hepatocytes in primary culture.
Topics: Adenosine Triphosphate; Albumins; Angiotensin II; Animals; Blotting, Northern; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gene Expression; Glucose; Liver; Male; Norepinephrine; Prazosin; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1994 |
Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Casein Kinases; Cell Cycle; Cell Division; Epidermal Growth Factor; Estrogens, Non-Steroidal; Humans; Insulin; Insulin Antagonists; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Isoflavones; Kinetics; Mice; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Resting Phase, Cell Cycle; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Epidermal growth factor counteracts the insulin induced expression of glucokinase in hepatocytes.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Gene Expression; Glucagon; Glucokinase; Insulin; Insulin Antagonists; Kinetics; Liver; Male; Rats; Rats, Wistar; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Stimulation of low-density lipoprotein uptake in HepG2 cells by epidermal growth factor via a tyrosine kinase-dependent, but protein kinase C-independent, mechanism.
Topics: Acetates; Cholesterol; Enzyme Activation; Epidermal Growth Factor; Esterification; Genistein; Humans; Indoles; Isoflavones; Lipoproteins, LDL; Protein Kinase C; Protein-Tyrosine Kinases; Sucrose; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Expression and regulation of transforming growth factor-beta 1 messenger ribonucleic acid and protein in cultured porcine Leydig and Sertoli cells.
Topics: Animals; Antibody Specificity; Blotting, Western; Cells, Cultured; Culture Media, Conditioned; Epidermal Growth Factor; Follicle Stimulating Hormone; Gene Expression Regulation; Immunohistochemistry; Leydig Cells; Male; RNA, Messenger; Sertoli Cells; Swine; Testosterone; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1994 |
Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive GTP-binding proteins.
Topics: Animals; Calcium; Cell Count; Cells, Cultured; Cytochalasin D; Epidermal Growth Factor; Glucose; Glycogen; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Lactates; Lactic Acid; Liver; Male; Pertussis Toxin; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1994 |
Protein kinase C-dependent and -independent pathways mediate epidermal growth factor (EGF) effects in human endometrial adenocarcinoma cell line KLE.
Topics: Adenocarcinoma; Alkaloids; Animals; Cell Division; Dose-Response Relationship, Drug; Endometrial Neoplasms; Epidermal Growth Factor; Female; Humans; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured | 1994 |
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.
Topics: Adenylate Cyclase Toxin; Animals; Carbachol; Cell Line; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Mice; Mitogen-Activated Protein Kinase 1; Oncogene Protein p21(ras); Phosphatidylinositols; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1994 |
A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.
Topics: 3T3 Cells; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acid; Cell Division; Cell Nucleus; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; DNA; Drug Synergism; Epidermal Growth Factor; Kinetics; Lysophospholipids; Mice; Mitogens; Phosphatidic Acids; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine | 1994 |
Actions of interleukin-2 on chorio-decidual prostaglandin biosynthesis.
Topics: Cells, Cultured; Chorion; Decidua; Dinoprostone; Epidermal Growth Factor; Female; Humans; Interleukin-1; Interleukin-2; Ionomycin; Tetradecanoylphorbol Acetate | 1993 |
Thyrotropin stimulates invasion and growth of follicular thyroid cancer cells via PKC- rather than PKA-activation.
Topics: Alkaloids; Cell Division; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Humans; Neoplasm Invasiveness; Pertussis Toxin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Epidermal growth factor and phorbol myristate acetate increase expression of the mRNA for cytosolic phospholipase A2 in glomerular mesangial cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Cytosol; Dactinomycin; Epidermal Growth Factor; Gene Expression Regulation; Glomerular Mesangium; Kinetics; Phospholipases A; Phospholipases A2; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1993 |
Nerve growth factor activates calcium-insensitive protein kinase C-epsilon in PC-12 rat pheochromocytoma cells.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Membrane; Cytoplasm; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Histones; Immunoblotting; Isoenzymes; Kinetics; Molecular Sequence Data; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1993 |
Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.
Topics: Animals; Cell Communication; Cell Line; Connexin 43; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Gap Junctions; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
Phosphatase inhibitors, gap junctional intercellular communication and [125I]-EGF binding in hamster fibroblasts.
Topics: Aluminum Compounds; Animals; Cell Communication; Cell Line; Connexin 43; Cricetinae; Cricetulus; Embryo, Mammalian; Epidermal Growth Factor; Ethers, Cyclic; Fibroblasts; Fluorides; Intercellular Junctions; Iodine Radioisotopes; Kinetics; Lung; Marine Toxins; Mesocricetus; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate; Vanadates; Vanadium Compounds | 1993 |
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Egtazic Acid; Epidermal Growth Factor; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gene Expression Regulation; Genes, ras; Mutation; Phospholipases A; Phospholipases A2; Phosphorylation; Precipitin Tests; Rats; Tetradecanoylphorbol Acetate; Transfection; Tritium; Tyrosine | 1993 |
Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells.
Topics: Blotting, Northern; Calcium; Cells, Cultured; DNA Probes; Egtazic Acid; Endothelium, Vascular; Epidermal Growth Factor; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Physical Stimulation; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
[Effect of epidermal growth factor (EGF) on mouse sperm capacitation].
Topics: Animals; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Isoflavones; Male; Mice; Mice, Inbred Strains; Phosphorylation; Protein-Tyrosine Kinases; Sperm Capacitation; Stimulation, Chemical; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Activation of phospholipase D in CHO cells transfected with the human epidermal growth factor (EGF) receptor: differential effects of protein kinase C activation and EGF.
Topics: Animals; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Phospholipase D; Phospholipids; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Thyroperoxidase mRNA in quiescent and proliferating thyroid epithelial cells: expression and subcellular localization studied by in situ hybridization.
Topics: Animals; Cell Division; Cell Nucleus; Cells, Cultured; Colforsin; Cytoplasm; DNA; Dogs; Epidermal Growth Factor; Epithelial Cells; Epithelium; In Situ Hybridization; Interphase; Iodide Peroxidase; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroglobulin; Thyroid Gland; Thyrotropin | 1993 |
Regulation of the Max gene expression by different mitogenic pathways in dog primary thyrocytes.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Cell Division; Cycloheximide; DNA-Binding Proteins; Dogs; Epidermal Growth Factor; Gene Expression; Genes, myc; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Transcription Factors | 1994 |
Mitogenic stimulation of HeLa cells increases the activity of the anoxic stress protein, LDH 6/k: suppression by queuine.
Topics: Amanitins; Cell Cycle; Cell Division; Cell Hypoxia; Cycloheximide; Cytosol; Epidermal Growth Factor; G1 Phase; Guanine; Heat-Shock Proteins; HeLa Cells; Humans; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Protein Kinase C; Receptor Protein-Tyrosine Kinases; RNA, Messenger; RNA, Transfer; Tetradecanoylphorbol Acetate | 1993 |
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.
Topics: Amino Acid Sequence; Animals; Anisomycin; Cell Line; Cell Nucleus; Chromatin; Epidermal Growth Factor; Genes, fos; Genes, jun; Genes, Regulator; High Mobility Group Proteins; Histones; Mice; Mice, Inbred C3H; Models, Biological; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Phosphoproteins; Phosphorylation; Polyenes; Protein Biosynthesis; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Ribosomes; Sirolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
Topics: Animals; Base Sequence; Binding Sites; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Fluocinolone Acetonide; Gene Expression; Genes, fos; Genes, jun; Genes, Reporter; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Proto-Oncogene Proteins c-jun; Skin; Tetradecanoylphorbol Acetate; Transfection; Tretinoin | 1994 |
A 40-kDa myelin basic protein kinase, distinct from erk1 and erk2, is activated in mitotic HeLa cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; G1 Phase; Glycogen Synthase Kinase 3; HeLa Cells; Histones; Humans; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Molecular Weight; Phosphorylation; Protein Denaturation; Protein Kinases; S Phase; Tetradecanoylphorbol Acetate | 1994 |
Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase. Comparison with the effects of insulin, growth factors and phorbol esters.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Growth Substances; Insulin; Molecular Sequence Data; Nerve Growth Factors; Neurites; PC12 Cells; Tetradecanoylphorbol Acetate; Thionucleotides | 1994 |
Detection of interleukin-1 activity in human bladder cancer cell lines.
Topics: Animals; Cell Division; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Escherichia coli; Humans; Interleukin-1; Lipopolysaccharides; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Evidence for involvement of a GTP-binding protein in activation of Ca2+ influx by epidermal growth factor in A431 cells: effects of fluoride and bacterial toxins.
Topics: Calcium; Calcium Channels; Cell Line; Cell Membrane; Cholera Toxin; Cyclic AMP; Epidermal Growth Factor; Fluorides; GTP-Binding Proteins; Humans; Ion Transport; Pertussis Toxin; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Pertussis toxin can distinguish the augmentary effect elicited by epidermal growth factor from that of phorbol ester on luteal adenylate cyclase activity.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cattle; Cell Membrane; Epidermal Growth Factor; Female; Luteal Cells; Pertussis Toxin; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells.
Topics: Animals; Blotting, Southern; Blotting, Western; Cells, Cultured; Dexamethasone; Dinoprostone; Epidermal Growth Factor; Epithelium; Gene Expression; Genes; In Vitro Techniques; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Trachea | 1993 |
Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3',5'-monophosphate in MCF7 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Breast Neoplasms; Cathepsin D; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Growth Substances; Humans; Insulin-Like Growth Factor I; Neoplasm Proteins; Polyunsaturated Alkamides; Proteins; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Transcription, Genetic; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1993 |
Heparin-binding epidermal growth factor-like growth factor expression in cultured fetal human vascular smooth muscle cells. Induction of mRNA levels and secretion of active mitogen.
Topics: Cell Division; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Cycloheximide; Epidermal Growth Factor; Fetus; Fibroblast Growth Factor 2; Gene Expression; Growth Substances; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kinetics; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Effects of cytokines, anti-cancer agents and cocarcinogen on DNA synthesis in hair bulb cells.
Topics: Antineoplastic Agents; Cells, Cultured; Cocarcinogenesis; Culture Media, Serum-Free; Cytarabine; Cytokines; DNA; Doxorubicin; Epidermal Growth Factor; Fibroblast Growth Factor 2; Hair; Humans; Interferon-gamma; Tetradecanoylphorbol Acetate | 1993 |
Characterization of high and low molecular weight forms of amphiregulin that differ in glycosylation and peptide core length. Evidence that the NH2-terminal region is not critical for bioactivity.
Topics: Amino Acid Sequence; Amphiregulin; Breast Neoplasms; Carbohydrate Conformation; Carbohydrate Sequence; Chemical Fractionation; Chromatography, Affinity; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Disaccharides; EGF Family of Proteins; Epidermal Growth Factor; Glycoproteins; Glycosylation; Growth Substances; Heparin; Humans; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Molecular Weight; N-Acetylneuraminic Acid; Oligosaccharides; Peptide Mapping; Sialic Acids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
[The effect of progesterone and tamoxifen on EGF-dependent activation of phospholipid turnover in uterine and breast tumor cells].
Topics: Adenocarcinoma; Breast Neoplasms; Chromatography, Thin Layer; Epidermal Growth Factor; Estradiol; Female; Humans; Phospholipids; Phosphorus Radioisotopes; Progesterone; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Neoplasms | 1993 |
alpha 1-Antitrypsin- and anchorage-independent growth of MCF-7 breast cancer cells.
Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Breast Neoplasms; Cell Division; Culture Media; Epidermal Growth Factor; Humans; Interleukin-1; Interleukin-6; Tetradecanoylphorbol Acetate; Trypsin Inhibitors; Tumor Cells, Cultured | 1993 |
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphorylation; Protein Kinase C; Protein Kinases; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1993 |
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Humans; Immunologic Factors; Insulin-Like Growth Factor I; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Protein kinase C inhibits arginine vasopressin-stimulated cAMP accumulation via a Gi-dependent mechanism.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arginine Vasopressin; Colforsin; Cyclic AMP; Diglycerides; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Kidney Tubules, Collecting; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1993 |
Cyclic adenosine monophosphate response in primary and subcultured bladder epithelial cells: inhibition by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Alkaloids; Animals; Calcimycin; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dogs; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Cells; Epithelium; Indomethacin; Models, Biological; Protein Kinase C; Second Messenger Systems; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1993 |
Epidermal growth factor stimulates phosphorylation of eukaryotic initiation factor 4B, independently of protein kinase C.
Topics: Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Initiation Factors; Humans; Peptide Initiation Factors; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Characterization of epidermal growth factor receptor in a rat thyroid cell line, FRTL-5.
Topics: Animals; Antibodies, Monoclonal; Bucladesine; Cell Division; Cell Line; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Insulin-Like Growth Factor I; Interleukin-1; Phosphorylation; Precipitin Tests; Rats; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1993 |
Epidermal growth factor induces prolactin mRNA in GH4C1 cells via a protein synthesis-dependent pathway.
Topics: Animals; Bucladesine; Colforsin; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Pituitary Gland, Anterior; Prolactin; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Puromycin; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Protein kinase A activators inhibit agonist induced prostaglandin production in human amnion.
Topics: Adenylyl Cyclases; Amnion; Bucladesine; Colforsin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Female; Fetus; Humans; In Vitro Techniques; Isoproterenol; Oxytocin; Pregnancy; Pregnancy Trimester, Third; Protein Kinases; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Regulation of phospholipid turnover by steroid hormones in endometrial carcinoma and breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Endometrial Neoplasms; Epidermal Growth Factor; Estradiol; Female; Gonadal Steroid Hormones; Humans; Neoplasms, Hormone-Dependent; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Progesterone; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Rapid and sustained phosphorylation of a calmodulin-binding protein (CaM-BP100) in NGF-treated PC12 cells.
Topics: Animals; Bradykinin; Brain; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Calmodulin-Binding Proteins; Carbachol; Cattle; Colforsin; Cyclic AMP; Cytosol; Epidermal Growth Factor; Fibroblast Growth Factor 2; Ionomycin; Kinetics; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein Kinases; Tetradecanoylphorbol Acetate; Thionucleotides | 1993 |
Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.
Topics: Alkaloids; Animals; Cell Line; Collagenases; Dexamethasone; Endopeptidases; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Fibroblasts; Gelatinases; Interleukin-1; Keratinocytes; Mammary Neoplasms, Experimental; Molecular Weight; Mouth Mucosa; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1993 |
Characterization of a unique enhancer element responsive to cyclic adenosine 3',5'-monophosphate and elevated calcium.
Topics: Base Sequence; Binding, Competitive; Calcium; Cell Line; Cell Nucleus; Cyclic AMP; DNA; Drug Interactions; Enhancer Elements, Genetic; Epidermal Growth Factor; Fibroblasts; Gene Expression; Molecular Sequence Data; Nuclear Proteins; Repetitive Sequences, Nucleic Acid; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Cross talk among tyrosine kinase receptors in PC12 cells: desensitization of mitogenic epidermal growth factor receptors by the neurotrophic factors, nerve growth factor and basic fibroblast growth factor.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Kinetics; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factors; PC12 Cells; Phosphates; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional communication is differentially regulated in a transformation-sensitive Syrian hamster embryo cell line compared to early passage SHE cells.
Topics: Animals; Cell Communication; Cell Line; Colforsin; Cricetinae; Cyclic AMP; Down-Regulation; Embryo, Mammalian; Epidermal Growth Factor; Gap Junctions; Mesocricetus; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Preparation of anti-phosphoserine and anti-phosphothreonine antibodies and their application in the study of insulin- and EGF-induced phosphorylation.
Topics: Animals; Antibodies; CHO Cells; Chromatography, Affinity; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Kinetics; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Rabbits; Receptor, Insulin; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes.
Topics: CDC2 Protein Kinase; Cell Cycle; Chromosome Aberrations; Cyclins; Epidermal Growth Factor; Humans; In Vitro Techniques; Karyotyping; Keratinocytes; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1993 |
Regulation of follistatin messenger ribonucleic acid in porcine granulosa cells by epidermal growth factor and the protein kinase-C pathway.
Topics: Animals; Dose-Response Relationship, Drug; Epidermal Growth Factor; Female; Follistatin; Gene Expression; Glycoproteins; Granulosa Cells; Protein Kinase C; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Growth and differentiation stimuli induce different and distinct increases in intracellular free calcium in human keratinocytes.
Topics: Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Epidermal Growth Factor; Humans; Keratinocytes; Tetradecanoylphorbol Acetate | 1993 |
Extracellular ATP-induced regulation of epidermal growth factor signaling in cultured renal LLC-PK1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Cytosol; Epidermal Growth Factor; ErbB Receptors; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kidney; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Epidermal growth factor is a potent inhibitor of renin secretion.
Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Epidermal Growth Factor; Genistein; Isoflavones; Male; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Renin; Tetradecanoylphorbol Acetate | 1993 |
Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells.
Topics: Animals; Azoxymethane; Base Sequence; Carcinogens; Colonic Neoplasms; Dinoprost; Dinoprostone; DNA, Neoplasm; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc | 1995 |
Protein tyrosine phosphorylation induced by epidermal growth factor and insulin-like growth factor-I in a rat clonal dental pulp-cell line.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Cell Line; Clone Cells; Dental Pulp; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor I; Isoflavones; Mice; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Receptor, IGF Type 1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Vanadates | 1995 |
Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Glioblastoma; Humans; Kinetics; Mice; Mitogen-Activated Protein Kinase Kinases; Protein Kinases; Recombinant Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Vanadates | 1995 |
Activators of protein kinase C but not of phospholipase C modulate adenylate cyclase-responses of normal pig epidermis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Animals; Bradykinin; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epinephrine; Histamine; Isoquinolines; Keratinocytes; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1995 |
Mechanism of action of epidermal growth factor-induced porcine oocyte maturation.
Topics: Animals; Bucladesine; Cyclic AMP; Dose-Response Relationship, Drug; Epidermal Growth Factor; Mice; Naphthalenes; Oocytes; Oogenesis; Phorbol Esters; Swine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1995 |
Epidermal growth factor induces Egr-1 messenger RNA and protein in mouse osteoblastic cells.
Topics: Animals; Base Sequence; Cell Line; Cycloheximide; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Immediate-Early Proteins; Mice; Molecular Sequence Data; Osteoblasts; Protein Synthesis Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors | 1995 |
Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction.
Topics: 3T3 Cells; Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Nucleus; Chromatin; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Ethers, Cyclic; ets-Domain Protein Elk-1; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; High Mobility Group Proteins; Histones; Isoenzymes; MAP Kinase Kinase 4; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Phosphorylation; Protein Binding; Protein Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Substrate Specificity; Tetradecanoylphorbol Acetate; Transcription Factors; Ultraviolet Rays | 1995 |
Phosphatidylcholine could be the source of 1,2-DAG which activates protein kinase C in EGF-stimulated colon carcinoma cells (HT29).
Topics: Colonic Neoplasms; Diglycerides; Drug Interactions; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; HT29 Cells; Humans; Phosphates; Phosphatidylcholines; Phosphatidylinositols; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
Phosphorylation of c-Jun stimulated in primary cultured rat liver parenchymal cells by a coplanar polychlorinated biphenyl.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Liver; Phosphorylation; Polychlorinated Biphenyls; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1996 |
Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Binding Sites; Cell Division; CHO Cells; Cricetinae; Epidermal Growth Factor; Estradiol; Humans; Insulin-Like Growth Factor I; Molecular Sequence Data; Protein Kinase C; Receptors, Estrogen; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Potentiation of mitogen-activated protein kinase by ethanol in embryonic liver cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Ethanol; GTP-Binding Proteins; Mice; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Humans; Kinetics; Mice; Mutagenesis; Peptide Mapping; Phosphopeptides; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Biosynthesis; Proteins; ras Guanine Nucleotide Exchange Factors; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Deletion; Sequence Tagged Sites; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Cells in vivo and in vitro from osteopetrotic mice homozygous for c-src disruption show suppression of synthesis of osteopontin, a multifunctional extracellular matrix protein.
Topics: 3T3 Cells; Animals; Base Sequence; Benzoquinones; Bone and Bones; Cell Adhesion; Cell Line; DNA Primers; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Homozygote; Lactams, Macrocyclic; Mice; Microscopy, Electron; Molecular Sequence Data; Osteopetrosis; Osteopontin; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Quinones; Rifabutin; Sialoglycoproteins; Tetradecanoylphorbol Acetate | 1996 |
Radiation with 1 Gy prevents the activation of the mitotic inducers mitosis-promoting factor (MPF) and cdc25-C in HeLa cells.
Topics: CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Epidermal Growth Factor; G2 Phase; HeLa Cells; Humans; Maturation-Promoting Factor; Mitosis; Neoplasm Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protamine Kinase; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate | 1996 |
B-Myb expression in vascular smooth muscle cells occurs in a cell cycle-dependent fashion and down-regulates promoter activity of type I collagen genes.
Topics: Animals; Aorta; Base Sequence; Binding Sites; Cattle; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Collagen; Culture Media, Serum-Free; Dactinomycin; DNA-Binding Proteins; Epidermal Growth Factor; Female; G1 Phase; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Kinetics; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Recombinant Proteins; RNA, Messenger; S Phase; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection | 1996 |
Role of protein kinase C in modulating epidermal growth factor- and phorbol ester-induced mammary epithelial cell growth in vitro.
Topics: Animals; Biological Transport; Cell Division; Cell Membrane; Cells, Cultured; Cytosol; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Female; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Mitogens; Molecular Weight; Phospholipids; Phosphorylation; Pregnancy; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
EGF modulation of Na+/H+ antiport in rat hepatocytes: different sensitivity in adult and fetal cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Fetus; Fluoresceins; Fluorescent Dyes; GTP-Binding Proteins; Hydroquinones; Kinetics; Liver; Ouabain; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1996 |
Phosphatidic acid mobilized by phospholipase D is involved in the phorbol 12-myristate 13-acetate-induced G2 delay of A431 cells.
Topics: 1-Propanol; Carcinoma, Squamous Cell; Diglycerides; Enzyme Activation; Epidermal Growth Factor; G2 Phase; Humans; Mitosis; Phosphatidic Acids; Phospholipase D; Prophase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Role of the Raf/mitogen-activated protein kinase pathway in p21ras desensitization.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Enzyme Activation; Epidermal Growth Factor; Estradiol; GRB2 Adaptor Protein; Membrane Proteins; Mice; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Receptors, Estradiol; Recombinant Fusion Proteins; Son of Sevenless Proteins; Tetradecanoylphorbol Acetate | 1996 |
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Epidermal Growth Factor; Gene Expression Regulation; Growth Substances; Humans; Molecular Sequence Data; Nerve Growth Factors; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; ras Proteins; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 1996 |
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.
Topics: Base Sequence; Calcimycin; Cell Line; Collagenases; Concanavalin A; Cycloheximide; Cytokines; Dexamethasone; DNA Primers; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; Fibroblasts; Fibrosarcoma; Gelatinases; Gene Expression Regulation, Enzymologic; Growth Substances; Humans; Immunoblotting; Interleukin-1; Lung; Matrix Metalloproteinase 1; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
Drug-induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cells.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Colforsin; Epidermal Growth Factor; Fluocinolone Acetonide; Glucocorticoids; Mice; Phenotype; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 1996 |
Modulation of keratinocyte growth factor (KGF) mRNA expression in human dermal fibroblasts grown in monolayer or within a collagen matrix.
Topics: Adolescent; Adult; Breast; Cell Division; Cells, Cultured; Cholera Toxin; Culture Media, Conditioned; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Humans; Indoles; Keratinocytes; Maleimides; Middle Aged; Protein Kinase C; RNA, Messenger; Signal Transduction; Skin; Surgery, Plastic; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Insulin potentiates mitogenic effect of epidermal growth factor on cultured guinea pig gastric mucous cells.
Topics: Animals; Calcium; Cell Division; Cells, Cultured; Drug Synergism; Epidermal Growth Factor; Gastric Mucosa; Guinea Pigs; Insulin; Intracellular Membranes; Male; Mitogens; Osmolar Concentration; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Expression of memory, differentiation, and repression of c-myc and p53 genes in human RD/TE-671 cells induced by a ureido-derivative of pyridine (UDP-4).
Topics: Cell Differentiation; Cell Division; DNA Replication; DNA, Neoplasm; Epidermal Growth Factor; Genes, myc; Genes, p53; Humans; Immunologic Memory; Nerve Growth Factors; Neuroectodermal Tumors, Primitive, Peripheral; Pyridines; Repressor Proteins; Rhabdomyosarcoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urea | 1996 |
Wortmannin and Li+ specifically inhibit clathrin-independent endocytic internalization of bulk fluid.
Topics: Ammonium Chloride; Androstadienes; Antibodies, Monoclonal; Calcium; Cell Line; Clathrin; Endocytosis; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Fibrosarcoma; Horseradish Peroxidase; Humans; Hydrogen-Ion Concentration; Lithium; Microscopy, Electron; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Proton-Translocating ATPases; Tetradecanoylphorbol Acetate; Transferrin; Tumor Cells, Cultured; Wortmannin | 1996 |
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; COS Cells; Enzyme Activation; Epidermal Growth Factor; Isoenzymes; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Induction of apoptosis in MDA-231 cells by protein synthesis inhibitors is suppressed by multiple agents.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Cycloheximide; DNA; Epidermal Growth Factor; Female; Humans; Protein Biosynthesis; Protein Synthesis Inhibitors; Ricin; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Role of cdc25-C phosphatase in the immediate G2 delay induced by the exogenous factors epidermal growth factor and phorbolester.
Topics: CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Epidermal Growth Factor; ErbB Receptors; G2 Phase; HeLa Cells; Humans; Ligands; Phosphoprotein Phosphatases; Phosphorylation; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Effects of some mammalian growth-promoting substances on insect cell cultures.
Topics: Animals; Cell Division; Cell Line; Epidermal Growth Factor; Fibroblast Growth Factors; Insulin; Mammals; Moths; Tetradecanoylphorbol Acetate | 1995 |
Effects of prolonged EGF treatment on phospholipid turnover and DAG formation in murine keratinocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Diglycerides; Epidermal Growth Factor; Inositol Phosphates; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphatidic Acids; Phosphatidylcholines; Phospholipids; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1996 |
Chymotrypsin-like enzyme secretion is stimulated in cultured epithelial cells during proliferation and in response to Actinobacillus actinomycetemcomitans.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Animals; Aprotinin; Cell Division; Chromatography, Affinity; Chymotrypsin; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epidermal Growth Factor; Epithelium; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Gingiva; Growth Substances; Humans; Keratinocytes; Periodontal Ligament; Skin; Substrate Specificity; Swine; Tetradecanoylphorbol Acetate; Trypsin Inhibitors | 1996 |
Induction of nerve growth factor-induced gene-B (NGFI-B) as an early event in the cyclic adenosine monophosphate response of dog thyrocytes in primary culture.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Colforsin; Conserved Sequence; Cyclic AMP; DNA-Binding Proteins; Dogs; Epidermal Growth Factor; Gene Expression Regulation; Gene Library; Humans; In Vitro Techniques; Mice; Molecular Sequence Data; Nuclear Receptor Subfamily 4, Group A, Member 1; Promoter Regions, Genetic; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Transcription Factors; Transcription, Genetic; Xenopus | 1996 |
Parietal cell MAP kinases: multiple activation pathways.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cyclic AMP; Cytosol; Enzyme Activation; Epidermal Growth Factor; Gastric Mucosa; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Parasympathomimetics; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity.
Topics: Cells, Cultured; Down-Regulation; Epidermal Growth Factor; Humans; Inositol Phosphates; Keratinocytes; Ornithine Decarboxylase; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1996 |
Translational augmentation of pro-matrix metalloproteinase 3 (prostromelysin 1) and a tissue inhibitor of metalloproteinases (TIMP)-1 mRNAs by epidermal growth factor and transforming growth factor alpha, but not by interleukin 1 alpha or 12-O-tetradecano
Topics: Cervix Uteri; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Epidermal Growth Factor; Female; Fibroblasts; Glycoproteins; Humans; Interleukin-1; Metalloendopeptidases; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor alpha | 1996 |
Hepatocyte growth factor is a paracrine regulator of rat prostate epithelial growth.
Topics: Animals; Base Sequence; Bucladesine; Cell Division; Cells, Cultured; Dinoprostone; DNA; DNA Primers; Epidermal Growth Factor; Epithelial Cells; Epithelium; Hepatocyte Growth Factor; Humans; Male; Polymerase Chain Reaction; Prostate; Proto-Oncogene Proteins c-met; Rats; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Multiple signal transduction pathways regulate clusterin (gp 80) gene expression in MDCK cells.
Topics: 1-Methyl-3-isobutylxanthine; Aldosterone; Alkaloids; Animals; Benzophenanthridines; Cell Line; Clusterin; Cyclic AMP; Dexamethasone; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Glycoproteins; Kidney; Kinetics; Molecular Chaperones; Phenanthridines; Progesterone; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Regulation of prostaglandin H synthase-2 in chorion and decidual cells.
Topics: Blotting, Western; Cells, Cultured; Chorion; Cyclooxygenase 2; Decidua; Epidermal Growth Factor; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Microsomes; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1996 |
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
Topics: 3T3 Cells; Adipocytes; Animals; Blood; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Ligands; Mice; Mitogens; Mutation; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection | 1996 |
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.
Topics: Amino Acid Sequence; Animals; COS Cells; Enzyme Activation; Epidermal Growth Factor; Isoenzymes; Molecular Sequence Data; Mutation; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Zinc Fingers | 1997 |
Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1.
Topics: 3T3 Cells; Animals; Antibodies; Binding, Competitive; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Division; Ceramides; Cholera Toxin; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; G(M1) Ganglioside; Lysophospholipids; Mice; Mitogens; Peptide Fragments; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Sphingolipids; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1996 |
Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes.
Topics: Animals; Carcinogens; Cells, Cultured; Down-Regulation; Enzyme Induction; Epidermal Growth Factor; Isoenzymes; Keratinocytes; Mice; Mice, Inbred SENCAR; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1996 |
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.
Topics: 3T3 Cells; Animals; Cell Division; Cell Line; COS Cells; Diglycerides; Enzyme Activation; Epidermal Growth Factor; Isoenzymes; Mice; Mitogens; Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; Signal Transduction; Spodoptera; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Protein kinase C in cultured human placental trophoblasts: identification of isoforms and role in cAMP signalling.
Topics: Animals; Blotting, Western; Brain; Cyclic AMP; Epidermal Growth Factor; Humans; Isoenzymes; Isoproterenol; Placenta; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Trophoblasts | 1996 |
Effect of growth factors on the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Rat-1 fibroblasts.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Culture Media, Serum-Free; Cyclic AMP; DNA; Endothelin-1; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Fructose-Bisphosphatase; Growth Substances; Lysophospholipids; Phosphofructokinase-1; Phosphofructokinase-2; Rats; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors.
Topics: Blotting, Northern; Cell Adhesion; Cell Adhesion Molecules; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Kalinin; Molecular Sequence Data; Platelet-Derived Growth Factor; Protein Conformation; RNA, Messenger; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation | 1996 |
Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells.
Topics: Blotting, Northern; Breast Neoplasms; Collagenases; Culture Media, Serum-Free; Cycloheximide; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Matrix Metalloproteinase 1; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Retinoic acids increase 17 beta-hydroxysteroid dehydrogenase type 1 expression in JEG-3 and T47D cells, but the stimulation is potentiated by epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate, and cyclic adenosine 3',5'-monophosphate only in J
Topics: 17-Hydroxysteroid Dehydrogenases; Breast Neoplasms; Choriocarcinoma; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Female; Humans; Isoenzymes; Pregnancy; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Uterine Neoplasms | 1997 |
Tumor necrosis factor-alpha regulates plasminogen activator inhibitor-1 in rat testicular peritubular cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Isoflavones; Male; Plasminogen Activator Inhibitor 1; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Staurosporine; Testis; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Extracellular matrix is required for MAP kinase activation and proliferation of rat glomerular epithelial cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Division; Cells, Cultured; Collagen; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; ErbB Receptors; Extracellular Matrix; Flavonoids; Kidney Glomerulus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Plastics; Rats; Tetradecanoylphorbol Acetate | 1997 |
Phosphorylation of A 27-kDa protein correlates with survival of protein-synthesis-inhibited MCF-7 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aurintricarboxylic Acid; Breast Neoplasms; Carcinoma; Cell Survival; Cycloheximide; Cytosol; Epidermal Growth Factor; Heat-Shock Proteins; Humans; Insulin-Like Growth Factor I; Isoelectric Point; Mitogens; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1997 |
Analysis of the ability of 12-O-tetradecanoylphorbol-13-acetate to induce epidermal hyperplasia, transforming growth factor-alpha, and skin tumor promotion in wa-1 mice.
Topics: Amphiregulin; Animals; Antineoplastic Agents; Carcinogens; EGF Family of Proteins; Epidermal Growth Factor; Female; Glycoproteins; Growth Substances; Heparin; Heparin-binding EGF-like Growth Factor; Hyperplasia; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred SENCAR; Mice, Mutant Strains; Neutrophils; RNA, Messenger; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cattle; Cell Division; Cells, Cultured; Cornea; DNA, Antisense; Elasticity; Epidermal Growth Factor; Epidermis; Epithelium; Fibroblast Growth Factor 2; Heparin-binding EGF-like Growth Factor; Hyaluronan Receptors; Hyaluronic Acid; Intercellular Signaling Peptides and Proteins; Keratinocytes; Keratins; Mice; Mice, Transgenic; Promoter Regions, Genetic; Skin; Tetradecanoylphorbol Acetate; Wound Healing | 1997 |
Antiproliferative effect of Pygeum africanum extract on rat prostatic fibroblasts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Division; DNA; Dose-Response Relationship, Drug; Epidermal Growth Factor; Fatty Alcohols; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblasts; Growth Substances; Insulin-Like Growth Factor I; Male; Phorbol 12,13-Dibutyrate; Plant Extracts; Prostate; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1997 |
Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D- and protein kinase C-dependent pathways in murine mammary adenocarcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Butanol; Adenocarcinoma; Animals; Butanols; Epidermal Growth Factor; Female; Mammary Neoplasms, Experimental; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator | 1997 |
Regulation of c-fos and c-jun expression by calcitonin in human breast cancer cells.
Topics: Blotting, Northern; Breast Neoplasms; Calcitonin; Carcinogens; Cell Division; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Glycoproteins; Humans; Insulin; Isoquinolines; Metalloendopeptidases; Protein Biosynthesis; Protein Kinase Inhibitors; Proteins; Receptors, Calcitonin; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured | 1997 |
Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.
Topics: Amino Acid Sequence; Amphiregulin; Antibodies; Cell Membrane; Cells, Cultured; EGF Family of Proteins; Endothelial Growth Factors; Endothelium, Vascular; Epidermal Growth Factor; Epitopes; ErbB Receptors; Glycoproteins; Growth Substances; GTP-Binding Proteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Membrane Glycoproteins; Peptide Fragments; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Proteoglycans; Receptors, Growth Factor; Receptors, Thrombin; Recombinant Proteins; Skin; Syndecan-1; Syndecan-4; Syndecans; Tetradecanoylphorbol Acetate; Thrombin; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wounds and Injuries | 1997 |
Protein kinase C and protein kinase A inhibit calcium-dependent but not stress-dependent c-Jun N-terminal kinase activation in rat liver epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Angiotensin II; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; Liver; Mitogen-Activated Protein Kinases; Models, Biological; Polyenes; Protein Kinases; Rats; Recombinant Proteins; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Wortmannin | 1997 |
The protein kinase A pathway inhibits c-jun and c-fos protooncogene expression induced by the protein kinase C and tyrosine kinase pathways in cultured human thyroid follicles.
Topics: Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Epidermal Growth Factor; Gene Expression; Genes, fos; Genes, jun; Humans; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Gland | 1997 |
Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.
Topics: Animals; Anticarcinogenic Agents; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phytic Acid; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Retinyl methyl ether down-regulates activator protein 1 transcriptional activation in breast cancer cells.
Topics: Breast Neoplasms; Carcinogens; Collagenases; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Genes, Reporter; HeLa Cells; Humans; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Retinoic Acid; Retinoid X Receptors; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Vitamin A | 1997 |
Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos.
Topics: Animals; Apoptosis; Asbestos, Crocidolite; Benzoxazoles; Biotin; Bromodeoxyuridine; Carcinogens; Cell Division; Deoxyuracil Nucleotides; DNA Fragmentation; Epidermal Growth Factor; Epithelial Cells; Fluorescent Dyes; Image Cytometry; Image Processing, Computer-Assisted; Indoles; Microscopy, Fluorescence; Mitogens; Pleura; Quinolinium Compounds; Rats; Rats, Inbred F344; Staining and Labeling; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Activation of MAP kinases, cPLA2 and reactive oxygen species formation by EGF and calcium mobilizing agonists in a human keratinocyte cell line.
Topics: Bradykinin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Ionophores; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Thapsigargin | 1997 |
Growth hormone attenuation of epidermal growth factor-induced mitogenesis.
Topics: 3T3 Cells; Animals; Cell Cycle; Cyclin D; Cyclins; DNA; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Human Growth Hormone; Humans; Mice; Phosphotyrosine; Protein-Tyrosine Kinases; Recombinant Proteins; S Phase; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Changes in protein expression during multistage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antigens, Surface; Carcinogens; Connexin 26; Connexins; Cyclin D1; Cyclins; Epidermal Growth Factor; Female; gamma-Glutamyltransferase; Heparin-binding EGF-like Growth Factor; Integrin alpha6beta4; Integrins; Intercellular Signaling Peptides and Proteins; Keratins; Mice; Mice, Inbred SENCAR; Neoplasm Proteins; Oncogene Proteins; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.
Topics: Animals; Anticarcinogenic Agents; Biflavonoids; Catechin; Cell Transformation, Neoplastic; Chemoprevention; Epidermal Growth Factor; Mice; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Signal Transduction; Tea; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 1997 |
Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Indoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oncogene Proteins, Viral; Open Reading Frames; Papillomaviridae; Protein Kinase C; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Differential effects of basic fibroblast growth factor, epidermal growth factor, transforming growth factor-alpha, and insulin-like growth factor-I on a hypothalamic gonadotropin-releasing hormone neuronal cell line.
Topics: Animals; Carcinogens; Cell Count; Cell Division; Cell Line, Transformed; Colforsin; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression; Gonadotropin-Releasing Hormone; Gonadotropins; Growth Substances; Hypothalamus; Insulin-Like Growth Factor I; Mice; Neurites; Neurons; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Transforming Growth Factor alpha; Transgenes; Tritium | 1997 |
Characterization of a phosphoprotein whose mRNA is regulated by the mitogenic pathways in dog thyroid cells.
Topics: Adenoviridae; Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; Cytoplasm; Dogs; Electrophoresis, Gel, Two-Dimensional; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Immunoblotting; Molecular Sequence Data; Phosphoproteins; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1997 |
Regulation of interleukin (IL)-6 and IL-8 production in an amnion-derived cell line by cytokines, growth factors, glucocorticoids, and phorbol esters.
Topics: Amnion; Cell Line; Dexamethasone; Epidermal Growth Factor; Female; Glucocorticoids; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Lipopolysaccharides; Pregnancy; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell-Free System; Cells, Cultured; Cholecystokinin; Enzyme Activation; Epidermal Growth Factor; Glutathione Transferase; Guanosine Triphosphate; Humans; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Pancreas; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; ras Proteins; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 1997 |
Lysophosphatidic acid inhibits epidermal-growth-factor-induced Stat1 signaling in human epidermoid carcinoma A431 cells.
Topics: Bradykinin; Carcinoma, Squamous Cell; DNA-Binding Proteins; Epidermal Growth Factor; Epinephrine; Genes, Reporter; GTP-Binding Proteins; Humans; Lysophospholipids; Nuclear Proteins; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Protein Kinase C; Receptors, Cell Surface; Regulatory Sequences, Nucleic Acid; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Type C Phospholipases | 1997 |
Effects of epidermal growth factor and estrogen on the regulation of the HMG-I/Y gene in human mammary epithelial cell lines.
Topics: Breast Neoplasms; Chromosome Mapping; DNA, Neoplasm; Epidermal Growth Factor; Estrogens; Female; Gene Expression; High Mobility Group Proteins; HMGA1a Protein; Humans; Neoplasm Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Interleukin (IL)-6 and IL-8 production by human amnion: regulation by cytokines, growth factors, glucocorticoids, phorbol esters, and bacterial lipopolysaccharide.
Topics: Amnion; Cells, Cultured; Culture Media, Conditioned; Cytokines; Dexamethasone; Epidermal Growth Factor; Female; Fibroblasts; Glucocorticoids; Growth Substances; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Lipopolysaccharides; Pregnancy; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epidermis; Mice; Phosphorylation; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 1998 |
Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Growth Substances; Humans; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mucins; Muscle Proteins; Neuropeptides; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Trefoil Factor-2; Trefoil Factor-3; Vanadates | 1998 |
Activation of the human histamine H2 receptor is linked to cell proliferation and c-fos gene transcription.
Topics: Cell Division; Cell Line; Cimetidine; Cloning, Molecular; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Epinephrine; Genes, fos; Genes, Reporter; Histamine; Humans; Inositol 1,4,5-Trisphosphate; Kinetics; Luciferases; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptors, Histamine H2; Recombinant Fusion Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1997 |
Activation of glomerular mesangial cells by hepatocyte growth factor through tyrosine kinase and protein kinase C.
Topics: Androstadienes; Animals; Catechols; Cells, Cultured; Cryopreservation; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Hepatocyte Growth Factor; Humans; Hydrogen-Ion Concentration; Kidney Neoplasms; Kinetics; Mice; Mice, Inbred Strains; Nitriles; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1998 |
Effects of protein tyrosine phosphatase inhibitors on EGF- and insulin-dependent mammary epithelial cell growth.
Topics: Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Female; Insulin; Mammary Glands, Animal; Mice; Mice, Inbred BALB C; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 1998 |
Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k.
Topics: 3T3 Cells; Androstadienes; Animals; Calcium; Down-Regulation; Epidermal Growth Factor; Ionomycin; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates; Wortmannin | 1998 |
The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Identification of Nore1 as a potential Ras effector.
Topics: Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Epidermal Growth Factor; Gene Expression Regulation; GTP-Binding Proteins; Guanosine Triphosphate; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Nuclear Proteins; Protein Binding; ras Proteins; Rats; Receptors, Steroid; Receptors, Thyroid Hormone; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Tetradecanoylphorbol Acetate | 1998 |
Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity.
Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Intestinal Mucosa; Mice; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrosine | 1998 |
Mitogenic-factor-dependent regulation of lipopolysaccharide and cytokine mixture-mediated hepatocyte nitric oxide synthesis in vitro.
Topics: Androstadienes; Animals; Cells, Cultured; Cytokines; Enzyme Activation; Epidermal Growth Factor; Female; Hepatocyte Growth Factor; Hydroxyurea; Lipopolysaccharides; Liver; Mice; Mice, Inbred ICR; Mitogens; Nitric Oxide; Oxidation-Reduction; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
The protein kinase C activator, phorbol ester, elicits disparate functional responses in androgen-sensitive and androgen-independent human prostatic cancer cells.
Topics: Androgens; Cell Division; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Immediate-Early; Genes, jun; Genes, myc; Humans; Male; Prostatic Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms.
Topics: Amnion; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Humans; In Situ Hybridization; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Okadaic Acid; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate | 1998 |
Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Guanosine Triphosphate; Indoles; Mutation; Protein Kinase C; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor, Muscarinic M1; Receptors, Muscarinic; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Fibroblast Growth Factor 2; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1998 |
Stimulation of p85/RING3 kinase in multiple organs after systemic administration of mitogens into mice.
Topics: Animals; Chromosomal Proteins, Non-Histone; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Kidney; Leukemia; Leukocytes; Liver; Lung; Mice; Myocardium; Organ Specificity; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate; Transcription Factors | 1998 |
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Carcinoma, Squamous Cell; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Hydroquinones; Isoenzymes; Microsomes; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C.
Topics: Alkaline Phosphatase; Animals; Calcium; Cells, Cultured; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Space; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Male; Metalloendopeptidases; Protein Kinase C; Protein Precursors; Rats; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate | 1998 |
Osmotic swelling-induced activation of the extracellular-signal-regulated protein kinases Erk-1 and Erk-2 in intestine 407 cells involves the Ras/Raf-signalling pathway.
Topics: ADP Ribose Transferases; Androstadienes; Botulinum Toxins; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Size; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Humans; Hypotonic Solutions; Indoles; Intestines; Iodine Radioisotopes; Maleimides; Osmotic Pressure; Phosphorylation; ras Proteins; Rubidium Radioisotopes; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Prostaglandin endoperoxide H synthase-2 expression in human amnion cells: involvement of tyrosine kinases in the regulation.
Topics: Amnion; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cycloheximide; Cyclooxygenase 2; Enzyme Induction; Epidermal Growth Factor; Female; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Membrane Proteins; Mitogen-Activated Protein Kinases; Okadaic Acid; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Quinones; Rifabutin; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
Angiotensin II stimulates ERK via two pathways in epithelial cells: protein kinase C suppresses a G-protein coupled receptor-EGF receptor transactivation pathway.
Topics: Angiotensin II; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; GTP-Binding Proteins; Humans; Liver; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcriptional Activation | 1998 |
Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Estradiol; Humans; Mammary Glands, Animal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Receptors, Estrogen; Serine; Tetradecanoylphorbol Acetate | 1998 |
Effect of a low-calcium environment on EGF inducible AP-1 binding activity in osteoblastic MC3T3-E1 cells.
Topics: Animals; Animals, Newborn; Base Sequence; Calcium; Cell Line; Cell Nucleus; Epidermal Growth Factor; Mice; Mice, Inbred C57BL; Oligonucleotide Probes; Osteoblasts; Skull; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 1997 |
Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Egtazic Acid; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Protein Kinase C; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate | 1998 |
PKC activation is required by EGF-stimulated Na(+)-H+ exchanger in human pleural mesothelial cells.
Topics: Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Humans; Pleura; Protein Kinase C; Receptor Protein-Tyrosine Kinases; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1998 |
MAP kinase mediates epidermal growth factor- and phorbol ester-induced prostacyclin formation in cardiomyocytes.
Topics: Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Epoprostenol; Heart Ventricles; Phosphorylation; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1998 |
Eps8, a tyrosine kinase substrate, is recruited to the cell cortex and dynamic F-actin upon cytoskeleton remodeling.
Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Animals; Blood; Catenins; Cell Adhesion Molecules; Cell Line; Cortactin; Cytoskeletal Proteins; Cytoskeleton; Delta Catenin; Detergents; Dogs; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Fibroblasts; Mice; Microfilament Proteins; Muscles; Octoxynol; Oncogene Protein pp60(v-src); Phosphoproteins; Proteins; Quail; Receptor, ErbB-2; Tetradecanoylphorbol Acetate | 1998 |
Function and expression of CD44 during spreading, migration, and invasion of murine carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Carcinogens; Cell Adhesion; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Hyaluronan Receptors; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
Topics: Activating Transcription Factor 1; Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Rats; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1998 |
Transcriptional regulation of fibroblast growth factor-2 expression in human astrocytes: implications for cell plasticity.
Topics: Astrocytes; Base Sequence; Binding Sites; Brain; Cell Nucleus; Cells, Cultured; Colforsin; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Interleukin-1; Luciferases; Mitosis; Molecular Sequence Data; Neuronal Plasticity; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Polymerase Chain Reaction; Promoter Regions, Genetic; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1998 |
Parathyroid hormone responses of cyclic AMP-, serum- and phorbol ester-responsive reporter genes in osteoblast-like UMR-106 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Blood; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Gene Expression Regulation; Genes, Reporter; Luciferases; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; Osteoblasts; Parathyroid Hormone; Rats; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; DNA-Binding Proteins; Drug Synergism; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Humans; Inhibins; Keratinocytes; Lung; Lung Neoplasms; Mink; RNA, Messenger; Signal Transduction; Smad6 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Cancer-associated expression of glycolipid sulfotransferase gene in human renal cell carcinoma cells.
Topics: Carcinoma, Renal Cell; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Kidney Neoplasms; Kidney Tubules, Proximal; Protein-Tyrosine Kinases; RNA, Messenger; Sulfotransferases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cloning, Molecular; DNA-Binding Proteins; Epidermal Growth Factor; ets-Domain Protein Elk-4; Gene Expression Regulation; Goldfish; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Muscle, Skeletal; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; ras Proteins; Receptors, Nicotinic; Repressor Proteins; Retina; Sequence Homology, Amino Acid; Tetradecanoylphorbol Acetate; Transcription Factors | 1998 |
TPA and butyrate increase cell sensitivity to the vacuolating toxin of Helicobacter pylori.
Topics: Animals; Bacterial Proteins; Bacterial Toxins; Biological Transport; Butyrates; Cell Differentiation; Cell Line; Chlorocebus aethiops; Dimethyl Sulfoxide; Dogs; Drug Synergism; Epidermal Growth Factor; HeLa Cells; Helicobacter pylori; HL-60 Cells; Humans; Jurkat Cells; Kinetics; Pentanoic Acids; Rats; Tetradecanoylphorbol Acetate; Tretinoin; Vacuoles; Vero Cells | 1998 |
Role of Cx43 phosphorylation and MAP kinase activation in EGF induced enhancement of cell communication in human kidney epithelial cells.
Topics: Antibodies; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Communication; Cell Line; Connexin 43; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Humans; Kidney; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; Gene Expression Regulation; Guanosine Triphosphate; Molecular Sequence Data; Oncogenes; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Sequence Homology, Amino Acid; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
Topics: ADAM Proteins; Catalytic Domain; Disintegrins; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Metalloendopeptidases; Muscle Proteins; Mutation; Protein Binding; Protein Kinase C; Protein Kinase C-delta; Protein Precursors; Protein Processing, Post-Translational; Recombinant Proteins; Solubility; Tetradecanoylphorbol Acetate | 1998 |
Hormonal regulation of 18S RNA, leptin mRNA, and leptin release in adipocytes from hypothyroid rats.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Colforsin; Dexamethasone; Dioxoles; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Hypothyroidism; Insulin; Leptin; Male; Oxytocin; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Ribosomal, 18S; Tetradecanoylphorbol Acetate | 1998 |
Regulation of proliferation and apoptosis by epidermal growth factor and protein kinase C in human ovarian surface epithelial cells.
Topics: Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Female; Gene Expression Regulation; Genes, Immediate-Early; Humans; Insulin-Like Growth Factor I; Ovary; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1999 |
Involvement of PYK2 in angiotensin II signaling of vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Chelating Agents; Egtazic Acid; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; Humans; Models, Biological; Muscle, Smooth, Vascular; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Epidermal Cells; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, Dominant; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection | 1998 |
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Muscarinic M3 and epidermal growth factor receptors activate mutually inhibitory signaling cascades in human neuroblastoma SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Carbachol; Cell Adhesion Molecules; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GRB2 Adaptor Protein; Humans; Neuroblastoma; Oncogene Protein v-cbl; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Receptor, Muscarinic M3; Receptors, Muscarinic; Retroviridae Proteins, Oncogenic; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Selective loss of PMA-stimulated expression of matrix metalloproteinase 1 in HaCaT keratinocytes is correlated with the inability to induce mitogen-activated protein family kinases.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Collagenases; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Genes, fos; Genes, jun; Humans; Keratinocytes; Matrix Metalloproteinase 1; Promoter Regions, Genetic; RNA, Messenger; Tetradecanoylphorbol Acetate | 1999 |
Potentiating effects of hyper-osmolality and epidermal growth factor on the release of arachidonic acid in human glomerular mesangial cells.
Topics: Arachidonic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Glomerular Mesangium; Glucose; Humans; Mannitol; Osmolar Concentration; Solutions; Tetradecanoylphorbol Acetate | 1999 |
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.
Topics: Animals; Cell Membrane; COS Cells; Epidermal Growth Factor; Phosphorylation; Proto-Oncogene Proteins c-raf; Serine; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Adhesion of human monocytic THP-1 cells to endothelial cell adhesion molecules or extracellular matrix proteins via beta1 integrins regulates heparin binding epidermal growth factor-like growth factor (HB-EGF) expression.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Colforsin; COS Cells; E-Selectin; Endothelium, Vascular; Epidermal Growth Factor; Extracellular Matrix Proteins; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Integrin beta1; Intercellular Adhesion Molecule-1; Intercellular Signaling Peptides and Proteins; Monocytes; Phorbol 12,13-Dibutyrate; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Vascular Cell Adhesion Molecule-1 | 1999 |
The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation.
Topics: Animals; Bucladesine; Buserelin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Indoles; Kinetics; Maleimides; Protein Kinase C; Rats; Receptors, LHRH; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Homologous and heterologous ligands downregulate follicle-stimulating hormone receptor mRNA in porcine granulosa cells.
Topics: Animals; Bucladesine; Cattle; Cells, Cultured; Cytochrome P-450 Enzyme System; Dinoprostone; Down-Regulation; Epidermal Growth Factor; Female; Follicle Stimulating Hormone; Granulosa Cells; Ligands; Luteinizing Hormone; Progesterone; Receptors, FSH; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate | 1999 |
IGF-1 or insulin, and the TSH cyclic AMP cascade separately control dog and human thyroid cell growth and DNA synthesis, and complement each other in inducing mitogenesis.
Topics: Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; DNA; Dogs; Drug Interactions; Epidermal Growth Factor; Humans; Insulin; Insulin-Like Growth Factor I; Mitogens; Protein Biosynthesis; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1999 |
A requirement for K+-channel activity in growth factor-mediated extracellular signal-regulated kinase activation in human myeloblastic leukemia ML-1 cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Activation; Epidermal Growth Factor; G1 Phase; Humans; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase 1; Potassium Channels; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Role of epidermal growth factor receptor in basal and stimulated colonic epithelial cell migration in vitro.
Topics: Acetates; Butyrates; Caco-2 Cells; Cell Movement; Colon; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Mitogens; Propionates; Protein Kinase C; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Valerates | 1999 |
Role of diacylglycerol (DAG) in hormonal induction of S phase in hepatocytes: the DAG-dependent protein kinase C pathway is not activated by epidermal growth factor (EGF), but is involved in mediating the enhancement of responsiveness to EGF by vasopressi
Topics: Angiotensin II; Animals; Bacterial Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cells, Cultured; Diglycerides; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; G1 Phase; GTP-Binding Proteins; Indoles; Liver; Male; Maleimides; Neuropeptides; Norepinephrine; Phospholipase D; Protein Kinase C; Rats; Rats, Wistar; S Phase; Tetradecanoylphorbol Acetate; Vasopressins | 1999 |
Opposite effects of Ras or PKC activation on the expression of the SPRR2A keratinocyte terminal differentiation marker.
Topics: Calcium; Cell Differentiation; Cells, Cultured; Cornified Envelope Proline-Rich Proteins; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation; Genes, fos; Humans; Indoles; Keratinocytes; Maleimides; Membrane Proteins; Mutation; Oncogene Protein p21(ras); Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
Morphological changes in the Golgi complex correlate with actin cytoskeleton rearrangements.
Topics: Actins; Androstadienes; Animals; Biological Transport; Brefeldin A; Cell Membrane; Chromones; Cytochalasin D; Cytoskeleton; Depsipeptides; Enzyme Inhibitors; Epidermal Growth Factor; Glycosaminoglycans; Golgi Apparatus; Lysophospholipids; Morpholines; Nucleic Acid Synthesis Inhibitors; Peptides, Cyclic; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin | 1999 |
Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells.
Topics: Amiloride; Biotin; Blotting, Western; Caco-2 Cells; Cell Membrane; Clone Cells; Epidermal Growth Factor; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Guanidines; Humans; Intracellular Membranes; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sulfones; Tetradecanoylphorbol Acetate | 1999 |
Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromatin; Epidermal Growth Factor; Fluorescent Antibody Technique; Gene Expression Regulation; Genes, fos; Genes, myc; Genes, ras; Histones; Mice; Mitogens; Okadaic Acid; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1999 |
Similar and divergent patterns in the regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of MMP-1 gene expression in benign and malignant human thyroid cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma, Follicular; Carcinoma; Carcinoma, Papillary; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinase 1; Protein Kinase C; Protein-Tyrosine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tissue Inhibitor of Metalloproteinase-1 | 1999 |
Heightened induction of c-jun mRNA by PMA, EGF and IL-1 in ataxia telangiectasia lymphoblasts.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; DNA-Binding Proteins; Epidermal Growth Factor; Gamma Rays; Gene Expression Regulation; Genes, jun; Humans; Interleukin-1; Lymphocytes; Mitogens; Protein Serine-Threonine Kinases; Proteins; Radiation Tolerance; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 1999 |
Involvement of the c-erbB-2 oncogene product in the EGF-induced cell motility of SK-OV-3 ovarian cancer cells.
Topics: Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Hepatocyte Growth Factor; Humans; Ovarian Neoplasms; Receptor, ErbB-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
[Post-receptor formation of active forms of oxygen in nonphagocytic cells].
Topics: Animals; Cell Line; Epidermal Growth Factor; ErbB Receptors; Interferon-gamma; Lipopolysaccharides; Mice; N-Formylmethionine Leucyl-Phenylalanine; Phagocytes; Platelet Activating Factor; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading.
Topics: Animals; Base Sequence; Blood; Cell Adhesion; Cell Membrane; Cell Movement; CHO Cells; Cricetinae; DNA Primers; DNA, Complementary; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Hydrolysis; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Metalloendopeptidases; Oncogene Proteins v-raf; Retroviridae Proteins, Oncogenic; Tetradecanoylphorbol Acetate | 1999 |
Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli.
Topics: Animals; Cell Differentiation; Cells, Cultured; Colforsin; DNA; Dogs; Epidermal Growth Factor; Gene Expression Regulation; Genes, Immediate-Early; Growth Substances; Insulin; Insulin-Like Growth Factor I; Kinetics; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Transcription, Genetic; Transcriptional Activation | 1999 |
Calcium and phosphatidylserine stimulate the self-association of conventional protein kinase C isoforms.
Topics: Animals; Calcimycin; Calcium; Cell Line; Cross-Linking Reagents; Dimerization; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Humans; Isoenzymes; Magnesium; Maleimides; Mice; Phosphatidic Acids; Phosphatidylinositols; Phosphatidylserines; Protein Kinase C; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate | 1999 |
Regulated migration of epidermal growth factor receptor from caveolae.
Topics: Amino Acid Substitution; Animals; Caveolin 1; Caveolins; Cell Fractionation; Cell Line; Cell Membrane; Cells, Cultured; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; HeLa Cells; Humans; L Cells; Membrane Proteins; Mice; Mutagenesis, Site-Directed; Organelles; Protein-Tyrosine Kinases; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Transformation, Neoplastic; Cells, Cultured; Crosses, Genetic; Epidermal Growth Factor; ErbB Receptors; Indoles; Isoenzymes; Models, Genetic; Mutagenesis, Insertional; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1999 |
Hydrogen peroxide activates p70(S6k) signaling pathway.
Topics: Androstadienes; Animals; Calcium; Catalase; Cell Line; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Indoles; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Reactive Oxygen Species; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
Topics: 3T3 Cells; Androstadienes; Animals; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Insulin; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 1999 |
Migratory phenotypes of HSC-3 squamous carcinoma cell line induced by EGF and PMA: relevance to migration of loosening of adhesion and vinculin-associated focal contacts with prominent filopodia.
Topics: Carcinogens; Carcinoma, Squamous Cell; Cell Adhesion; Cell Movement; Epidermal Growth Factor; Fibronectins; Humans; Intercellular Junctions; Pseudopodia; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinculin | 1999 |
Effect of epidermal growth factor on sodium-dependent L-alanine transport in LLC-PK1 cells.
Topics: Alanine; Animals; Biological Transport, Active; Epidermal Growth Factor; Humans; LLC-PK1 Cells; Protein Kinase C; Sodium; Swine; Tetradecanoylphorbol Acetate | 2000 |
Phospholipase D stimulation by receptor tyrosine kinases mediated by protein kinase C and a Ras/Ral signaling cascade.
Topics: Bacterial Proteins; Bacterial Toxins; Carbachol; Cell Line; Cell Membrane; Dose-Response Relationship, Drug; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; GTP Phosphohydrolases; Humans; Insulin; MAP Kinase Signaling System; Phospholipase D; Protein Kinase C; ral GTP-Binding Proteins; ral Guanine Nucleotide Exchange Factor; ras Proteins; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Phosphorylation and regulation of Raf by Akt (protein kinase B).
Topics: Cell Division; Cell Line; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Fusion Proteins; Signal Transduction; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Kidney; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Opossums; Parathyroid Hormone; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate | 1999 |
Urokinase (u-PA) and the u-PA receptor. Modulation of in vitro invasiveness of human bladder cancer cell lines.
Topics: Basement Membrane; Collagen; Drug Combinations; Epidermal Growth Factor; Humans; Interferon-gamma; Laminin; Neoplasm Invasiveness; Neoplasm Metastasis; Proteoglycans; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urokinase-Type Plasminogen Activator | 1999 |
Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains.
Topics: Biological Transport; Calcimycin; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Ligands; Metalloendopeptidases; Peptide Fragments; Protein Engineering; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2000 |
Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways.
Topics: Animals; Carbachol; Cattle; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dogs; Epidermal Growth Factor; Humans; Insulin; Kinetics; Myocardium; rap1 GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 2000 |
Protein kinase C is involved in enhanced airway smooth muscle cell growth in hyperresponsive rats.
Topics: Animals; Bronchi; Bronchial Hyperreactivity; Cattle; Cell Division; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Tyrosine | 2000 |
Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats.
Topics: Aging; Animals; Apoptosis; Brain; Cell Differentiation; Cell Division; Cerebral Cortex; Cytosol; Energy Intake; Enzyme Activators; Epidermal Growth Factor; Isoenzymes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitosis; Myelin Sheath; Neurons; p38 Mitogen-Activated Protein Kinases; Phospholipase C gamma; Phosphorylation; Phosphotransferases; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
Regulation of inducible cAMP early repressor expression by gastrin and cholecystokinin in the pancreatic cell line AR42J.
Topics: Animals; Benzodiazepinones; Cell Line; Cholecystokinin; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Epidermal Growth Factor; Gastrins; Gene Expression Regulation; Nerve Growth Factor; Pancreas; PC12 Cells; Phenylurea Compounds; Phosphorylation; Rats; Repressor Proteins; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2000 |
Rap1-suppressed tumorigenesis is concomitant with the interference in ras effector signaling.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; Humans; Insulin; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Nerve Growth Factor; rap1 GTP-Binding Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2000 |
Suppression of vitamin D receptor and induction of retinoid X receptor alpha expression during squamous differentiation of cultured keratinocytes.
Topics: Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances; Humans; Infant; Interferon-gamma; Keratinocytes; Male; Receptors, Calcitriol; Receptors, Retinoic Acid; Retinoid X Receptors; Tetradecanoylphorbol Acetate; Transcription Factors | 2000 |
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Cycle Proteins; Cell Line; Cloning, Molecular; Culture Media; Culture Media, Serum-Free; DNA, Complementary; Epidermal Growth Factor; Female; Gene Expression Regulation; Genetic Variation; Guanine Nucleotide Exchange Factors; HeLa Cells; HT29 Cells; Humans; Male; Mice; Molecular Sequence Data; Oncogene Proteins; Protein Isoforms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; RNA; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Tissue Distribution; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Characterization of the amnion-derived AV3 cell line for use as a model for investigation of prostaglandin-cytokine interactions in human amnion.
Topics: Amnion; Cell Line; Cyclooxygenase 2; Cytokines; Dinoprostone; Epidermal Growth Factor; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; Interleukin-8; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
Topics: Carrier Proteins; Chromones; Culture Media, Serum-Free; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Lymphokines; Male; Morpholines; Neovascularization, Pathologic; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C.
Topics: Animals; beta Catenin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Culture Media; Cytoskeletal Proteins; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Genes, Reporter; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Lithium; Microtubule-Associated Proteins; Mitogens; Protein Kinase C; Proto-Oncogene Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Activation; Transfection; Wnt Proteins; Zebrafish Proteins | 2000 |
Proto-oncogene ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells.
Topics: Animals; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Genes, ras; Glutathione Transferase; Growth Substances; GTP Phosphohydrolases; Insulin; Isoenzymes; Microsomes; Nerve Growth Factor; PC12 Cells; Rats; Tetradecanoylphorbol Acetate; Tretinoin | 2000 |
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
Topics: Amino Acid Sequence; Catalytic Domain; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Indoles; Insulin; Ionomycin; Isoquinolines; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha | 2000 |
Retinoic acid affects the EGF-R signaling pathway during differentiation induction of human endometrial adenocarcinoma cells.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenocarcinoma; Cell Adhesion; Cell Differentiation; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Cytoskeleton; Endometrial Neoplasms; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gelsolin; GRB2 Adaptor Protein; Humans; Isotretinoin; Membrane Proteins; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proteins; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 2000 |
Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.
Topics: Androstadienes; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Growth Substances; Hepatocyte Growth Factor; Insulin; Kinetics; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Wortmannin | 2000 |
The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.
Topics: Carbachol; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Protein Kinase C; Receptor, Muscarinic M3; Receptors, Muscarinic; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Synergism between interferon-gamma and cAMP in induction of hepatocyte growth factor in human skin fibroblasts.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cells, Cultured; Cyclic AMP; Drug Synergism; Epidermal Growth Factor; Female; Fibroblasts; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Infant; Interferon-beta; Interferon-gamma; Skin; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate | 2000 |
Influence of proliferation, differentiation and dedifferentiation factors on the expression of the lysosomal cysteine proteinase cathepsin L (CL) in thyroid cancer cell lines.
Topics: Adenocarcinoma, Follicular; Carcinoma; Cathepsin L; Cathepsins; Cell Differentiation; Cell Division; Colforsin; Cysteine Endopeptidases; Endopeptidases; Enzyme Induction; Enzyme Precursors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Insulin; Lysosomes; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Neoplasms; Thyrotropin; Tumor Cells, Cultured | 2000 |
Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts.
Topics: 3T3 Cells; Adenoviridae; Adult; Animals; Cell Division; Cell Movement; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Decorin; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Matrix Proteins; Female; Fibroblasts; Flavonoids; Genetic Vectors; Humans; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2000 |
Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro.
Topics: Butyrates; Caco-2 Cells; Cell Division; Cell Movement; Colon; Epidermal Growth Factor; Epithelial Cells; Humans; Oligonucleotides, Antisense; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 2000 |
Participation of reactive oxygen intermediates in the angiotensin II-activated signaling pathways in vascular smooth muscle cells.
Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Carbazoles; Carvedilol; Cells, Cultured; Epidermal Growth Factor; Hydrogen Peroxide; Muscle, Smooth, Vascular; Propanolamines; Rats; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
TSH and cAMP do not signal mitogenesis through Ras activation.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cell Cycle; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Activation; Epidermal Growth Factor; Guanosine Triphosphate; Hepatocyte Growth Factor; Insulin; Mitogens; ras Proteins; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors | 2000 |
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Topics: 14-3-3 Proteins; Animals; Antibodies; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Cells, Cultured; Colforsin; COS Cells; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Serine; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2000 |
Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways.
Topics: Animals; Epidermal Growth Factor; Ferritins; Genes, Reporter; Homeostasis; Iron; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Pituitary Gland; Protein Binding; Protein Kinase C; Rats; Response Elements; RNA; RNA-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured; Up-Regulation | 2000 |
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins | 2000 |
Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.
Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Chromones; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; Estradiol; Female; Gene Expression; Half-Life; Humans; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function.
Topics: Animals; beta-Adrenergic Receptor Kinases; Cell Division; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; GTP-Binding Proteins; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Mutation; Osteoblasts; Phosphorylation; Rats; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 2000 |
Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase.
Topics: Arachidonate 12-Lipoxygenase; Base Sequence; DNA Primers; DNA-Binding Proteins; Epidermal Growth Factor; Fungal Proteins; Gene Expression Regulation, Enzymologic; Genes, ras; Humans; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Saccharomyces cerevisiae Proteins; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 2000 |
Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cells, Cultured; COS Cells; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Ribosomal Protein S6 Kinases; Stress, Physiological; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2000 |
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Division; Cell Line; Cyclin A; Cyclin D1; Epidermal Growth Factor; Gene Expression Regulation; Genes, myc; Humans; Indomethacin; Insulin-Like Growth Factor I; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases; Salicylates; Tetradecanoylphorbol Acetate | 2000 |
EGF inhibits muscarinic receptor-mediated calcium signaling in a human salivary cell line.
Topics: Binding, Competitive; Calcium; Calcium Signaling; Carbachol; Cell Line; Diglycerides; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Space; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscarinic Agonists; Muscarinic Antagonists; Phosphorylation; Protein Kinase C; Quinuclidinyl Benzilate; Receptors, Muscarinic; Salivary Glands; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.
Topics: Acetyltransferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromosomes, Artificial, Bacterial; Cloning, Molecular; Cyclic AMP Response Element-Binding Protein; Embryo, Mammalian; Epidermal Growth Factor; Mice; Mice, Inbred Strains; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proteins; Recombinant Proteins; Restriction Mapping; Ribosomal Protein S6 Kinases, 90-kDa; Stem Cells; Tetradecanoylphorbol Acetate | 2000 |
Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.
Topics: 3T3 Cells; Animals; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ets-Domain Protein Elk-1; Hepacivirus; Humans; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Viral Core Proteins | 2000 |
Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts.
Topics: Animals; Biological Clocks; Bucladesine; Calcimycin; Cell Cycle Proteins; Cell Line; Circadian Rhythm; Colforsin; Culture Media; Dimethyl Sulfoxide; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Insulin; Nuclear Proteins; Okadaic Acid; Period Circadian Proteins; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 2000 |
Regulation by ceramide of epidermal growth factor signal transduction and mitogenesis in cell lines overexpressing the growth factor receptor.
Topics: Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Ceramides; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Inositol Phosphates; Isoenzymes; Mice; Mitogens; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2000 |
Mitogenic signal of epidermal growth factor in chick embryo hepatocytes: role of PKCalpha.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Chick Embryo; Diglycerides; Dinoprostone; DNA; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hepatocytes; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mitogens; Myristic Acid; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Quinacrine; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine | 2000 |
Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Blotting, Western; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Peptides; Phosphorylation; Plasmids; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2001 |
Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry.
Topics: Animals; Calcimycin; Calcium; Cell Culture Techniques; Cell Line; Enzyme Activation; Epidermal Growth Factor; Ionomycin; Kidney Medulla; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin; Urea | 2001 |
Extracellular ATP activates multiple signalling pathways and potentiates growth factor-induced c-fos gene expression in MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Anisomycin; Breast Neoplasms; Carcinogens; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Growth Substances; Humans; Parathyroid Hormone-Related Protein; Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Epidermal growth factor activates store-operated calcium channels in human glomerular mesangial cells.
Topics: Calcium Channels; Calcium Signaling; Cells, Cultured; Epidermal Growth Factor; Glomerular Mesangium; Humans; Naphthalenes; Patch-Clamp Techniques; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tyrphostins | 2001 |
Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells.
Topics: Cells, Cultured; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; Flavonoids; Genes, Dominant; Humans; I-kappa B Kinase; Immediate-Early Proteins; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protein Kinase C; Protein Serine-Threonine Kinases; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Substrate Specificity; Tetradecanoylphorbol Acetate; Thromboplastin; Transcription Factors; Tumor Necrosis Factor-alpha; Umbilical Veins; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells.
Topics: Animals; Biotinylation; Blotting, Northern; Colonic Neoplasms; Culture Media, Conditioned; DNA; DNA, Complementary; Epidermal Growth Factor; Epiregulin; Gene Library; Genes, ras; Humans; Ligands; Mice; Mice, Nude; Oncogene Protein p21(ras); Polymerase Chain Reaction; Precipitin Tests; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Up-Regulation | 2000 |
Modulation of cyclin D1 and its signaling components by the phorbol ester TPA and the tyrosine phosphatase inhibitor vanadate.
Topics: Animals; Cell Division; Cell Line; Cell Membrane; Cyclin D1; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Flavonoids; Indoles; Isoenzymes; Kinetics; Maleimides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Vanadates | 2001 |
Identification of a novel AU-Rich element in the 3' untranslated region of epidermal growth factor receptor mRNA that is the target for regulated RNA-binding proteins.
Topics: 3' Untranslated Regions; Base Sequence; Breast Neoplasms; Cytoplasm; DNA Mutational Analysis; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Regulatory Sequences, Nucleic Acid; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2001 |
Effect of PKC-zeta mediating Ang II-stimulated activation of CCDPK on rat cardiac fibroblast proliferation.
Topics: Angiotensin II; Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Epidermal Growth Factor; Fibroblasts; Flavonoids; Isoenzymes; Mitogen-Activated Protein Kinase Kinases; Myocardium; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 2000 |
The autocrine loop of epidermal growth factor receptor-epidermal growth factor / transforming growth factor-alpha in malignant rhabdoid tumor cell lines: heterogeneity of autocrine mechanism in TTC549.
Topics: Adult; Antibodies, Monoclonal; Cell Differentiation; Cell Division; Cell Line; Child; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Male; Reverse Transcriptase Polymerase Chain Reaction; Rhabdoid Tumor; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2001 |
Studies on the mechanism by which a tumor promoter inhibits binding of epidermal growth factor to cellular receptors.
Topics: Animals; Binding Sites; Carcinogens; Cell Membrane; Drug Resistance; Endocytosis; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Mice; Neoplasm Proteins; Protein Binding; Temperature; Tetradecanoylphorbol Acetate | 1980 |
Inhibition of epidermal growth factor binding to cultured mouse epidermal cells by tumor promoters.
Topics: Animals; Carcinogens; Depression, Chemical; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Mice; Phorbol Esters; Protein Binding; Tetradecanoylphorbol Acetate | 1980 |
Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.
Topics: Amino Acid Substitution; Animals; Catalytic Domain; COS Cells; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Humans; Microtubules; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; ras Proteins; Tetradecanoylphorbol Acetate; Zinc Fingers | 2001 |
Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Androstadienes; Animals; Cell Line; Cell Membrane; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Kinetics; MAP Kinase Signaling System; Mice; Phosphatidylinositol 3-Kinases; Phosphoserine; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Regulation of Ras signaling specificity by protein kinase C.
Topics: Animals; COS Cells; Enzyme Activation; Epidermal Growth Factor; Nerve Growth Factor; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-raf; ral Guanine Nucleotide Exchange Factor; ras Proteins; Rats; Sequence Deletion; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Differential effects of growth hormone and insulin-like growth factor I on human endothelial cell migration.
Topics: Cell Line; Cell Movement; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; Human Growth Hormone; Humans; Indoles; Insulin-Like Growth Factor I; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Protein Kinase C; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering.
Topics: Animals; Antigens, CD; Cell Adhesion; Cell Line; Cell Movement; Chromones; Cycloheximide; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Integrin alpha2; Integrins; Kidney; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Receptors, Collagen; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2001 |
NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Base Sequence; Calcimycin; Calcium; Cell Differentiation; Chromosomes, Human, Pair 5; Colforsin; Culture Media, Serum-Free; DNA, Complementary; DNA, Neoplasm; Epidermal Growth Factor; Female; Fibroblast Growth Factors; Gene Expression Regulation, Neoplastic; Humans; Ion Channels; Ionophores; Membrane Proteins; Mice; Molecular Sequence Data; Myocardium; Neoplasm Proteins; Nerve Growth Factor; Nerve Tissue Proteins; Open Reading Frames; Organ Specificity; Ovary; PC12 Cells; Pheochromocytoma; Polymerase Chain Reaction; Potassium Chloride; Protein Structure, Tertiary; Rats; Second Messenger Systems; Sequence Alignment; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate | 2001 |
Key role of PKC and Ca2+ in EGF protection of microtubules and intestinal barrier against oxidants.
Topics: Calcimycin; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cell Membrane Permeability; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Hydrogen Peroxide; Hypochlorous Acid; Indoles; Intestinal Mucosa; Isoenzymes; Maleimides; Microtubules; Models, Biological; Oxidants; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Induction of collecting duct morphogenesis in vitro by heparin-binding epidermal growth factor-like growth factor.
Topics: Animals; Base Sequence; Cells, Cultured; Collagen; Culture Media; DNA Primers; Epidermal Growth Factor; Gels; Heparin-binding EGF-like Growth Factor; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Collecting; Mice; Morphogenesis; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor beta | 2001 |
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.
Topics: Dimerization; Dynamins; Endocytosis; Epidermal Growth Factor; ErbB Receptors; GTP Phosphohydrolases; HeLa Cells; Humans; Phosphoamino Acids; Phosphorylation; Protein Binding; Receptor, ErbB-2; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Protein kinase C-alpha(1b)-adrenoceptor coimmunoprecipitation: effect of hormones and phorbol myristate acetate.
Topics: Adrenergic alpha-Agonists; Animals; Cell Line; Endothelin-1; Epidermal Growth Factor; Fibroblasts; Hormones; Immunoblotting; Isoenzymes; Lysophospholipids; Norepinephrine; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate | 2001 |
Stable luciferase reporter cell lines for signal transduction pathway readout using GAL4 fusion transactivators.
Topics: Binding Sites; Cell Line; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Enzyme Activation; Epidermal Growth Factor; Fungal Proteins; Gene Expression; Genes, Reporter; HeLa Cells; Humans; Luciferases; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection | 2001 |
Constitutive association of c-N-Ras with c-Raf-1 and protein kinase C epsilon in latent signaling modules.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Membrane; Culture Media, Serum-Free; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Genes, ras; Guanosine Triphosphate; Isoenzymes; Kinetics; Mice; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2001 |
Regulation of membrane metalloproteolytic cleavage of L-selectin (CD62l) by the epidermal growth factor domain.
Topics: ADAM Proteins; ADAM17 Protein; Amino Acid Sequence; Animals; Cell Membrane; Conserved Sequence; Epidermal Growth Factor; L-Selectin; Metalloendopeptidases; Mice; Molecular Sequence Data; Rats; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Regulation of differentiation- and proliferation-inducers on Lewis antigens, alpha-fucosyltransferase and metastatic potential in hepatocarcinoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Division; Cell Movement; Epidermal Growth Factor; Fucosyltransferases; Humans; Lewis Blood Group Antigens; Lewis X Antigen; Liver Neoplasms; Neoplasm Metastasis; Phenotype; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 2001 |
Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells.
Topics: Blood Proteins; Carcinogens; Carrier Proteins; Cell Hypoxia; Cobalt; Dimerization; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Male; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Subunits; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Up-Regulation | 2001 |
Persistent versus transient map kinase (ERK) activation in the proliferation of lung epithelial type 2 cells.
Topics: Animals; Cattle; Cell Division; Cells, Cultured; Culture Media; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pulmonary Alveoli; Rats; Tetradecanoylphorbol Acetate | 2001 |
A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.
Topics: Androstadienes; Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Chlorocebus aethiops; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; GTP Phosphohydrolases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Mutation; Plasmids; Protein Kinase C; Protein Structure, Tertiary; Proto-Oncogene Proteins c-raf; ras Proteins; Receptors, Cell Surface; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation; Transfection; Vero Cells; Wortmannin | 2001 |
Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells.
Topics: Animals; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Genes, Reporter; JNK Mitogen-Activated Protein Kinases; Kinetics; Luciferases; Mice; Mitogen-Activated Protein Kinases; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Skin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Epidermal growth factor regulation of equine glycoprotein hormone alpha subunit expression in trophoblast cells.
Topics: Animals; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Epidermal Growth Factor; Female; Flavonoids; Glycoprotein Hormones, alpha Subunit; Horses; Mitogen-Activated Protein Kinase Kinases; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Trophoblasts | 2001 |
A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.
Topics: Amyloid beta-Protein Precursor; Cell Line, Transformed; Epidermal Growth Factor; Epithelium, Corneal; Humans; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Activation of Raf-1 is defective in annexin 6 overexpressing Chinese hamster ovary cells.
Topics: Animals; Annexin A6; CHO Cells; Cricetinae; Enzyme Activation; Epidermal Growth Factor; Guanosine Triphosphate; Mitogen-Activated Protein Kinases; Protein Binding; Proto-Oncogene Proteins c-raf; ras Proteins; Rats; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 2001 |
Regulation of ANP clearance receptors by EGF in mesangial cells from NOD mice.
Topics: Animals; Atrial Natriuretic Factor; Autoradiography; Cell Line; Curcumin; Cyclic GMP; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Glomerular Mesangium; Guanylate Cyclase; Insulin-Like Growth Factor I; Mice; Mice, Inbred NOD; Platelet-Derived Growth Factor; Radioligand Assay; Receptors, Atrial Natriuretic Factor; RNA, Messenger; Tetradecanoylphorbol Acetate | 2001 |
Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.
Topics: Animals; Anticarcinogenic Agents; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Fruit; Glucosides; Glycosides; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Plants, Medicinal; Proto-Oncogene Proteins c-jun; Rubiaceae; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2001 |
Down-regulation of growth factor-stimulated MAP kinase signaling in cytotoxic drug-resistant human neuroblastoma cells.
Topics: Active Transport, Cell Nucleus; Adenosine; Antineoplastic Agents; Cell Nucleus; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Growth Substances; Humans; Lysophospholipids; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neuroblastoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Role of PKC and MAP kinase in EGF- and TPA-induced connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells.
Topics: Animals; Cell Communication; Cell Line; Chlordan; Connexin 43; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Liver; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 2001 |
Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells.
Topics: Calcimycin; Carcinogens; Carcinoma, Squamous Cell; Colforsin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Gravitation; Humans; Ionophores; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rotation; Signal Transduction; Space Flight; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Weightlessness; Weightlessness Simulation | 1992 |
Altered gravity conditions affect early EGF-induced signal transduction in human epidermal A431 cells.
Topics: Calcimycin; Centrifugation; Colforsin; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, fos; Gravitation; Gravity, Altered; Humans; Protein Kinase C; Receptor Aggregation; Rotation; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Cell signaling pathways mediating epidermal growth factor stimulation of Na:K:2Cl cotransport activity in rabbit corneal epithelial cells.
Topics: Animals; Benzofurans; Cell Division; Cell Line, Transformed; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Ethers, Cyclic; Fluorescence; Ion Transport; Kinetics; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Rabbits; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Controls of EGF-induced morphological transformation of human bronchial epithelial cells.
Topics: Bronchi; Bucladesine; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Isoquinolines; Kinetics; Phosphorylation; Pseudopodia; Respiratory Mucosa; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2001 |
Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo.
Topics: Animals; Cadmium; Carcinogens; Cell Line; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; Flavonoids; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Ultraviolet Rays | 2001 |
Myosin II heavy chain isoforms are phosphorylated in an EGF-dependent manner: involvement of protein kinase C.
Topics: Alanine; Amino Acid Substitution; Blotting, Western; Cell Line; Cell Membrane; Cloning, Molecular; Enzyme Activation; Epidermal Growth Factor; Humans; Male; Mutagenesis, Site-Directed; Myosin Heavy Chains; Myosin Type II; Phosphorylation; Prostate; Protein Isoforms; Protein Kinase C; Protein Transport; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells.
Topics: Angiotensin II; Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibronectins; Glomerular Mesangium; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Up-Regulation | 2001 |
Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Histones; MAP Kinase Signaling System; Mice; Phosphorylation; ras Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 2002 |
Regulation of mesangial cell hexokinase activity and expression by heparin-binding epidermal growth factor-like growth factor: epidermal growth factors and phorbol esters increase glucose metabolism via a common mechanism involving classic mitogen-activat
Topics: Animals; Cell Line; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Glomerular Mesangium; Glucose; Heparin-binding EGF-like Growth Factor; Hexokinase; Immunohistochemistry; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Isoenzymes; Ligands; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
[Autocrine regulation of hexokinase activity by HB-EGF in mesangial cells].
Topics: Animals; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Genistein; Glomerular Mesangium; Heparin-binding EGF-like Growth Factor; Hexokinase; Intercellular Signaling Peptides and Proteins; Mice; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
New strategy for antedrug application: development of metalloproteinase inhibitors as antipsoriatic drugs.
Topics: Amphiregulin; Animals; Cell Line; Disease Models, Animal; Drug Stability; EGF Family of Proteins; Epidermal Growth Factor; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Hydroxylamines; Hyperplasia; Intercellular Signaling Peptides and Proteins; Isoquinolines; Magnetic Resonance Spectroscopy; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Protease Inhibitors; Psoriasis; Recombinant Proteins; Skin; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines | 2002 |
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Biological Transport; Cell Nucleus; COS Cells; Cytoplasm; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescent Antibody Technique; Immunosorbent Techniques; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Mice; Microscopy, Confocal; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tyrosine 3-Monooxygenase | 2002 |
Fibrinogen and fibrin are anti-adhesive for keratinocytes: a mechanism for fibrin eschar slough during wound repair.
Topics: Animals; Antigens, CD; Bucladesine; Carcinogens; Cations, Divalent; Cell Adhesion; Cell Communication; Cell Movement; Centrifugation; DNA, Complementary; Epidermal Cells; Epidermal Growth Factor; Epidermis; Extracellular Matrix Proteins; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Gene Expression; Humans; Integrin beta3; Keratinocytes; Platelet Membrane Glycoproteins; Receptors, Vitronectin; Tetradecanoylphorbol Acetate; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Wound Healing | 2001 |
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatography, Affinity; Colforsin; COS Cells; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Ligands; Male; MAP Kinase Signaling System; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Phosphopeptides; Phosphorylation; Plasmids; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tumor Cells, Cultured | 2002 |
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.
Topics: Animals; Blotting, Western; Calcium; Calmodulin; COS Cells; DNA, Complementary; Edetic Acid; Epidermal Growth Factor; Gene Deletion; Glycoproteins; Growth Substances; Ions; Mice; Monomeric GTP-Binding Proteins; Nerve Tissue Proteins; Plasmids; Precipitin Tests; Protein Binding; ras Proteins; Recombinant Proteins; Signal Transduction; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Two-Hybrid System Techniques | 2002 |
Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo.
Topics: Animals; Epidermal Growth Factor; Free Radicals; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Luminol; Monocytes; Neutrophils; Rats; Reactive Oxygen Species; Reperfusion Injury; Respiratory Burst; Tetradecanoylphorbol Acetate | 2002 |
Expression of chromogranin A and somatostatin receptors in pancreatic AR42J cells.
Topics: Animals; Cell Differentiation; Chromogranin A; Chromogranins; Epidermal Growth Factor; Gastrins; Neurosecretory Systems; Pancreas; Pancreatic Hormones; Rats; Receptors, Somatostatin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Epidermal growth factor-induced depletion of the intracellular Ca2+ store fails to activate capacitative Ca2+ entry in a human salivary cell line.
Topics: Calcium; Carbachol; Cell Line; Epidermal Growth Factor; Humans; Ion Transport; Recombinant Proteins; Salivary Glands; Tetradecanoylphorbol Acetate; Thapsigargin | 2002 |
Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells.
Topics: Apoptosis; Cell Cycle; Cycloheximide; DNA-Binding Proteins; Epidermal Growth Factor; Genetic Vectors; Humans; Nuclear Receptor Subfamily 4, Group A, Member 1; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Proteins; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tretinoin; Tumor Cells, Cultured | 2002 |
Epidermal growth factor inhibits amiloride-sensitive sodium absorption in renal collecting duct cells.
Topics: Amiloride; Animals; Antineoplastic Agents; Carcinogens; Cell Line, Transformed; Cell Membrane; Diuretics; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epithelial Sodium Channels; Gene Expression; Kidney Tubules, Collecting; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Polycystic Kidney Diseases; RNA, Messenger; Sodium; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
The interaction and phosphorylation of tropomodulin by protein kinase Calpha in N/N 1003A lens epithelial cells.
Topics: Animals; Blotting, Western; Carrier Proteins; Cells, Cultured; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; Isoenzymes; Lens, Crystalline; Microfilament Proteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Rabbits; Tetradecanoylphorbol Acetate; Threonine; Transfection; Tropomodulin | 2002 |
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling.
Topics: Animals; Caveolin 1; Caveolins; Cell Fractionation; Cell Membrane; COS Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Phospholipase D; Phosphorylation; Point Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Rats; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 2002 |
Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation.
Topics: Cell Line; Culture Media, Serum-Free; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gonadotropin-Releasing Hormone; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Transcriptional Activation | 2003 |
EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells.
Topics: Cell Division; Cell Line, Transformed; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Epithelium, Corneal; Humans; Isoenzymes; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 2002 |
Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis.
Topics: ADAM Proteins; ADAM12 Protein; Adipose Tissue; Animals; Animals, Newborn; Chromosome Mapping; Embryo, Mammalian; Epidermal Growth Factor; Fibroblasts; Gene Expression Regulation, Developmental; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; Mice, Mutant Strains; Muscle Proteins; Muscle, Skeletal; Phenotype; Rats; Regeneration; Tetradecanoylphorbol Acetate | 2003 |
Activation of the MAP kinase pathway induces chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) expression in human breast cancer cell lines.
Topics: Blotting, Western; Breast Neoplasms; Butadienes; COUP Transcription Factor I; COUP Transcription Factor II; COUP Transcription Factors; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Oncostatin M; Peptides; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transcription Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2003 |
Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA.
Topics: Animals; Cells, Cultured; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Lysine; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Point Mutation; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tyrosine | 2003 |
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Eye Proteins; Lacrimal Apparatus; Male; Peroxidase; Phenylephrine; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins | 2003 |
The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling ca
Topics: Animals; Carcinogens; Chlorocebus aethiops; Cytokines; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Signal Transduction; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transcriptional Activation; Vero Cells | 2003 |
Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland.
Topics: Adrenergic alpha-Agonists; Animals; Calcium; Cholinergic Agonists; Enzyme Activation; Epidermal Growth Factor; Intracellular Membranes; Lacrimal Apparatus; Male; Mitogen-Activated Protein Kinases; Osmolar Concentration; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 2002 |
Regulation of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of MMP, and progesterone secretion in luteinized granulosa cells from normally ovulating women with polycystic ovary disease.
Topics: Adult; Blotting, Western; Colforsin; Cyclic AMP-Dependent Protein Kinases; Epidermal Growth Factor; Female; Granulosa Cells; Humans; Luteinization; Matrix Metalloproteinase 9; Polycystic Ovary Syndrome; Progesterone; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1 | 2003 |
Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors.
Topics: Animals; Arsenites; Carcinogens; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Hepatocyte Growth Factor; Humans; Hypoglycemic Agents; Imidazoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sodium Compounds; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 2003 |
Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cattle; Cell Membrane; Cell Nucleus; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Humans; Lysophospholipids; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Transport; ras Proteins; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Theca Cells | 2003 |
Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts.
Topics: 1-Butanol; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Glycerophospholipids; Growth Substances; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptides; Phosphatidic Acids; Phospholipase D; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Swine; Tetradecanoylphorbol Acetate | 2003 |
c-Jun regulates eyelid closure and skin tumor development through EGFR signaling.
Topics: Animals; Apoptosis; Carcinogens; Cell Division; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Eyelids; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, jun; Genetic Predisposition to Disease; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Models, Biological; Papilloma; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transgenes | 2003 |
Difference in responsiveness of human esophageal squamous cell carcinoma lines to epidermal growth factor for MMP-7 expression.
Topics: Carcinogens; Carcinoma, Squamous Cell; DNA-Binding Proteins; Epidermal Growth Factor; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Luciferases; Lymphoid Enhancer-Binding Factor 1; Matrix Metalloproteinase 7; Mutagenesis, Site-Directed; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2003 |
The 'Abtropfung phenomenon' revisited: Dermal nevus cells from congenital nevi cannot activate matrix metalloproteinase 2 (MMP-2).
Topics: Adolescent; Cell Line, Tumor; Cell Movement; Cells, Cultured; Child; Child, Preschool; Dermis; Enzyme Activation; Epidermal Growth Factor; Gelatinases; Humans; Infant; Infant, Newborn; Isoenzymes; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Melanoma; Nevus; Nevus, Pigmented; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-2 | 2003 |
Protein kinase Calpha negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor.
Topics: Breast Neoplasms; Cell Movement; Cell Size; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2003 |
Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development.
Topics: Animals; Butadienes; Cell Differentiation; Cell Size; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Mesoderm; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Myosin Heavy Chains; Nitriles; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate; Transcription Factors; Xenopus Proteins | 2003 |
Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.
Topics: Animals; Blotting, Western; Cell Line; Epidermal Growth Factor; Epithelial Cells; Gap Junctions; Liver; Mitogen-Activated Protein Kinases; Polychlorinated Biphenyls; Rats; Signal Transduction; Sphingomyelin Phosphodiesterase; src-Family Kinases; Tetradecanoylphorbol Acetate | 2003 |
PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.
Topics: ADAM Proteins; ADAM12 Protein; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Angiotensin II; Cell Line; Cell Membrane; Cytoplasm; Cytoskeletal Proteins; Epidermal Growth Factor; Gene Deletion; Genetic Vectors; Glutathione Transferase; Heparin-binding EGF-like Growth Factor; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Metalloendopeptidases; Microscopy, Confocal; Molecular Sequence Data; Muscle Proteins; Phosphoproteins; Precipitin Tests; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection; Two-Hybrid System Techniques; Up-Regulation | 2003 |
Protein kinase C mediates induced secretion of vascular endothelial growth factor by human glioma cells.
Topics: Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; Genistein; Glioma; Humans; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrphostins; Vascular Endothelial Growth Factor A | 2003 |
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin | 2003 |
Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Astrocytes; Base Sequence; Blotting, Northern; Cells, Cultured; Cloning, Molecular; Cyclic CMP; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; Excitatory Amino Acid Transporter 1; Fetus; Gene Expression Regulation; Glutamic Acid; Humans; Luciferases; Mice; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; RNA; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factors; Transcription Initiation Site; Transcription, Genetic; Transcriptional Activation; Transfection; Transforming Growth Factor alpha; Upstream Stimulatory Factors | 2003 |
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.
Topics: ADAM Proteins; ADAM12 Protein; ADAM17 Protein; Amphiregulin; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betacellulin; Cells, Cultured; Disintegrins; EGF Family of Proteins; Embryo, Mammalian; Endopeptidases; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Fibroblasts; Genotype; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ligands; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Muscle Proteins; Phenylalanine; Protease Inhibitors; Protein Structure, Tertiary; Tetradecanoylphorbol Acetate; Thiophenes; Transforming Growth Factor alpha | 2004 |
Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis.
Topics: Animals; Carcinogens; Cell Division; Cells, Cultured; DNA-Binding Proteins; Epidermal Growth Factor; Epidermis; ErbB Receptors; Female; Keratinocytes; Mice; Mice, Inbred SENCAR; Mice, Transgenic; Signal Transduction; Skin Neoplasms; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators | 2004 |
Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells.
Topics: Angiotensin II; Animals; Base Sequence; Binding Sites; Cell Line, Tumor; Cloning, Molecular; Conserved Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; Epithelial Cells; Fibroblast Growth Factor 2; Gene Expression; HeLa Cells; Humans; Immediate-Early Proteins; Kruppel-Like Transcription Factors; Luciferases; Male; Metribolone; Mice; Molecular Sequence Data; Oligonucleotides; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; Rats; Recombinant Fusion Proteins; Rodentia; Sequence Deletion; Sequence Homology, Nucleic Acid; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transfection; Tretinoin; Tumor Necrosis Factor-alpha | 2004 |
A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.
Topics: Animals; Base Sequence; Carcinogens; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Nude; Molecular Sequence Data; Phosphorylation; RNA, Small Interfering; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factors | 2004 |
The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.
Topics: Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Diacylglycerol Kinase; Epidermal Growth Factor; Humans; Leukemia, Plasma Cell; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate | 2004 |
Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate.
Topics: Animals; Carcinogens; Cells, Cultured; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Feedback, Physiological; Fibroblasts; Kidney; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells.
Topics: Adenylyl Cyclases; Animals; Base Sequence; Cell Line; CHO Cells; Colforsin; Cricetinae; DNA Primers; Enzyme Activation; Epidermal Growth Factor; Humans; Isoproterenol; Kidney; Kinetics; Mutagenesis, Site-Directed; Protein Kinase C; Proto-Oncogene Proteins c-raf; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 2005 |
PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms.
Topics: Base Sequence; Bronchi; Cell Line; DNA Primers; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; MAP Kinase Signaling System; Mucin 5AC; Mucins; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transforming Growth Factor alpha | 2004 |
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways.
Topics: Active Transport, Cell Nucleus; Blotting, Western; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; HeLa Cells; Humans; Immunoblotting; Ligands; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phenotype; Proto-Oncogene Proteins c-fos; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate | 2004 |
Differential phosphorylation of p38 induced by apoptotic and anti-apoptotic stimuli in murine hepatocytes.
Topics: Animals; Apoptosis; Carcinogens; Caspases; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Hepatocytes; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Blotting, Northern; Blotting, Western; Cells, Cultured; Cholera Toxin; Cyclic AMP Response Element-Binding Protein; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epidermal Cells; Epidermal Growth Factor; Epidermis; Fibroblasts; Hepatocyte Growth Factor; Humans; Keratinocytes; Phosphorylation; RNA, Messenger; Stereoisomerism; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tretinoin; Up-Regulation | 2005 |
Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites.
Topics: Animals; Binding Sites; DNA-Binding Proteins; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genes, jun; JNK Mitogen-Activated Protein Kinases; MEF2 Transcription Factors; Mice; Myogenic Regulatory Factors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Response Elements; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Ultraviolet Rays | 2005 |
MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.
Topics: Acetylation; Animals; Anisomycin; Cell Line; Cell Nucleus; Chromatin; Epidermal Growth Factor; Histones; Hydroxamic Acids; Interphase; Mice; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 8; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.
Topics: CDC2 Protein Kinase; Cell Line, Tumor; Densitometry; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Mitosis; Models, Biological; Nocodazole; Paclitaxel; Phosphorylation; Protein Binding; Protein Biosynthesis; Proto-Oncogene Proteins c-raf; Purines; Roscovitine; Signal Transduction; SOS1 Protein; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Vinblastine | 2005 |
MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.
Topics: Animals; Anisomycin; Cells, Cultured; CREB-Binding Protein; DNA-Binding Proteins; Epidermal Growth Factor; Fibroblasts; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Receptors, Thyroid Hormone; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2005 |
Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.
Topics: Animals; Becaplermin; Cell Cycle; Cell Cycle Proteins; Cyclin D1; Epidermal Growth Factor; Epithelial Cells; Fibroblasts; Mice; NIH 3T3 Cells; Platelet-Derived Growth Factor; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; ras Proteins; Receptors, Platelet-Derived Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 2005 |
Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.
Topics: 14-3-3 Proteins; beta Catenin; Cadherins; Caveolae; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Cytoskeletal Proteins; Cytosol; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; HeLa Cells; Humans; MAP Kinase Signaling System; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Prohibitins; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; raf Kinases; ras Proteins; Repressor Proteins; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection | 2005 |
Na+/K+/Cl- cotransporter activates MAP-kinase cascade downstream to protein kinase C, and upstream to MEK.
Topics: Animals; BALB 3T3 Cells; Bumetanide; Epidermal Growth Factor; ErbB Receptors; Furosemide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Mitogens; Models, Biological; Phosphorylation; Protein Kinase C; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate | 2006 |
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins | 2006 |
Cortactin affects cell migration by regulating intercellular adhesion and cell spreading.
Topics: Actin-Related Protein 2-3 Complex; Actins; Adherens Junctions; beta Catenin; Cadherins; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Movement; Cell Shape; Cortactin; Culture Media, Serum-Free; Cytoskeleton; Epidermal Growth Factor; Fibronectins; Gene Expression; Humans; Membrane Proteins; Microscopy, Fluorescence; Occludin; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Vinculin | 2006 |
Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes.
Topics: Animals; Bradykinin; Carbazoles; Cattle; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Indoles; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Protein Kinase C; Receptor, Bradykinin B2; Tetradecanoylphorbol Acetate; Thymidine; Trachea; Tritium | 2006 |
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.
Topics: Alanine; Amino Acid Sequence; Animals; Anisomycin; Cell Line; Chlorocebus aethiops; Cytoplasm; Epidermal Growth Factor; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ionophores; Lysophospholipids; Male; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Peptide Fragments; Phosphorylation; Protein Structure, Tertiary; Serine; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Vero Cells | 2006 |
Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.
Topics: 3T3 Cells; Alanine; Animals; Butadienes; Cells, Cultured; Chlorocebus aethiops; COS Cells; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Growth Hormone; Humans; Janus Kinase 2; MAP Kinase Kinase 1; Mass Spectrometry; Mice; Mutation; Nitriles; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Repressor Proteins; STAT5 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.
Topics: Adaptor Proteins, Signal Transducing; Catalytic Domain; Cell Line; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Intracellular Signaling Peptides and Proteins; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Quinolines; Tetradecanoylphorbol Acetate | 2006 |
Involvement of the paxillin pathway in JB6 Cl41 cell transformation.
Topics: Animals; Base Sequence; Cell Growth Processes; Cell Line; Cell Transformation, Neoplastic; Down-Regulation; Epidermal Growth Factor; MAP Kinase Kinase 4; Mice; Molecular Sequence Data; Paxillin; Phosphorylation; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Serine; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection | 2006 |
The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells.
Topics: Annexin A1; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Progression; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Western; Calcium; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 2; Genes, src; Ionomycin; Lacrimal Apparatus; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phenylephrine; Phosphorylation; Protein Kinase C; Protein Kinases; Rats; Tetradecanoylphorbol Acetate; Time Factors | 2006 |
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Topics: 3T3-L1 Cells; Acetophenones; Adipocytes; Adipogenesis; Animals; Benzopyrans; Carbazoles; Cell Differentiation; Cell Membrane; Cell Proliferation; Chromans; Cytosol; Epidermal Growth Factor; Gene Expression; Genes, Dominant; Indoles; Mice; Mutant Proteins; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Transport; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2006 |
A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells.
Topics: Animals; Aromatase; Chorionic Gonadotropin, beta Subunit, Human; Enzyme Activation; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Follicle Stimulating Hormone, Human; Granulosa Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Gonadotropin; RNA, Messenger; Tetradecanoylphorbol Acetate | 2006 |
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Amphiregulin; Amyloid Precursor Protein Secretases; Animals; Betacellulin; Calcium; Calmodulin; Chlorocebus aethiops; COS Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Ionophores; Ligands; Membrane Proteins; Mice; Protein Structure, Tertiary; Recombinant Fusion Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2007 |
Role of phosphatidylinositol 4,5-bisphosphate in the activation of cytosolic phospholipase A2-alpha.
Topics: Animals; Arachidonic Acids; Base Sequence; Binding Sites; Calcimycin; Calcium; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cytosol; Enzyme Activation; Epidermal Growth Factor; Group IV Phospholipases A2; Ionophores; Isoenzymes; Membrane Lipids; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C delta; Phospholipases A; Phospholipases A2; Phosphorylation; Prostaglandins; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2006 |
The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Epidermal Growth Factor; ets-Domain Protein Elk-1; Extracellular Signal-Regulated MAP Kinases; Genes, fos; Genes, jun; Glioblastoma; Humans; Isoenzymes; Models, Biological; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 2007 |
Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts.
Topics: Bradykinin; Calcium; Calcium Channels; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Econazole; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Humans; Nitric Oxide; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Tetradecanoylphorbol Acetate; Vanadates | 2006 |
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Proliferation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Intercellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Monte Carlo Method; Nerve Growth Factor; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Rats; Receptor, trkA; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2007 |
Morphological and functional differentiation of HSG cells: role of extracellular matrix and trpc 1.
Topics: Amylases; Basement Membrane; Calcium; Calcium Signaling; Cell Differentiation; Cell Line; Cell Proliferation; Cell Shape; Enzyme Activation; Enzyme Activators; Epidermal Growth Factor; Extracellular Matrix; Humans; Protein Kinases; Salivary Ducts; Tetradecanoylphorbol Acetate; Transfection; TRPC Cation Channels | 2007 |
Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.
Topics: Adenylyl Cyclases; Aprotinin; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activators; Epidermal Growth Factor; Fibroblast Growth Factors; Flavonoids; Humans; Indoles; Insulin; Iodine; Iodine Radioisotopes; Maleimides; Mesylates; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Plasminogen Inactivators; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Pyrroles; RNA, Messenger; Serine Proteinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Time Factors; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator | 2007 |
Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Differentiation; Cell Division; Epidermal Growth Factor; G1 Phase; Glucosides; HL-60 Cells; Humans; Muscle Cells; Phenols; Resting Phase, Cell Cycle; Resveratrol; Stilbenes; Tetradecanoylphorbol Acetate | 2007 |
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme Inhibitors; Epidermal Growth Factor; Fireflies; Flavonoids; Genes, Reporter; Luciferases; MAP Kinase Kinase 1; Mice; Recombinant Proteins; Tetradecanoylphorbol Acetate | 2007 |
The role of glycogen synthase kinase 3beta in the transformation of epidermal cells.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice; Mice, Inbred BALB C; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection | 2007 |
Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway.
Topics: Animals; Binding Sites; Cell Line; Epidermal Growth Factor; Equol; Extracellular Signal-Regulated MAP Kinases; Glycine max; Isoflavones; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Models, Molecular; Molecular Structure; Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-fos; ras Proteins; Replication Protein C; Ribosomal Protein S6 Kinases, 90-kDa; Tetradecanoylphorbol Acetate | 2007 |
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformation.
Topics: Animals; Base Sequence; Carcinogens; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Growth Factor; G1 Phase; Mice; Molecular Sequence Data; NIH 3T3 Cells; Ribosomal Protein S6 Kinases, 90-kDa; Sequence Homology, Nucleic Acid; Tetradecanoylphorbol Acetate; Transfection | 2007 |
The effect of concomitant stimulation with cholecystokinin and epidermal growth factor on extracellular signal-regulated kinase (ERK) activity in pancreatic acinar cells.
Topics: Animals; Blotting, Western; Carbachol; Cholecystokinin; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Male; Muscarinic Agonists; Pancreas, Exocrine; Phosphorylation; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Sincalide; Tetradecanoylphorbol Acetate; Time Factors | 2007 |
Fucoidan from Laminaria cichorioides inhibits AP-1 transactivation and cell transformation in the mouse epidermal JB6 cells.
Topics: Animals; Cell Adhesion; Cell Line; Cell Transformation, Neoplastic; Epidermal Cells; Epidermal Growth Factor; Laminaria; MAP Kinase Signaling System; Mice; Phosphorylation; Polysaccharides; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcriptional Activation | 2008 |
Mitogen- and stress-activated kinase 1-mediated histone H3 phosphorylation is crucial for cell transformation.
Topics: Animals; Cell Growth Processes; Cell Transformation, Neoplastic; Enzyme Activation; Epidermal Growth Factor; G1 Phase; Histones; Isoquinolines; Mice; Phosphorylation; Protein Kinase Inhibitors; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Skin; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2008 |
Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras.
Topics: Animals; Blotting, Western; Cricetinae; Epidermal Growth Factor; Galectin 3; Genes, ras; Guanosine Triphosphate; Humans; Immunoprecipitation; Neoplasms; ras Guanine Nucleotide Exchange Factors; ras Proteins; Rats; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2008 |
Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.
Topics: Animals; Cells, Cultured; Cumulus Cells; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Meiosis; Oocytes; Phosphorylation; Protein Kinase C; Quinazolines; Receptors, Androgen; Swine; Tetradecanoylphorbol Acetate; Tyrphostins | 2008 |
The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.
Topics: Animals; Cell Line; Connexin 43; Endocytosis; Enzyme Activation; Epidermal Growth Factor; Gap Junctions; Mitogen-Activated Protein Kinases; Octoxynol; Phosphorylation; Protein Kinase C; Rats; Solubility; Tetradecanoylphorbol Acetate | 2008 |
Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line, Tumor; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Neoplasms; Peptides; Phenylmercuric Acetate; Protease Inhibitors; Protein Isoforms; Protein Kinase C; Protein Structure, Tertiary; Sequence Alignment; Spectrometry, Mass, Electrospray Ionization; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Vanadates | 2008 |
Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication.
Topics: Animals; Cell Communication; Cell Line; Connexin 43; Electrophoretic Mobility Shift Assay; Epidermal Growth Factor; ErbB Receptors; Gap Junctions; Mitogen-Activated Protein Kinase Kinases; Phosphorylation; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 2009 |
Effect of inhibitors of mitogen-activated protein kinase kinase on alpha(1B)-adrenoceptor phosphorylation.
Topics: Androstadienes; Animals; Butadienes; Calcium Signaling; Cell Line; Cricetinae; Endothelin-1; Epidermal Growth Factor; Flavonoids; Genistein; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Norepinephrine; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Adrenergic, alpha-1; RNA, Small Interfering; Staurosporine; Tetradecanoylphorbol Acetate; Wortmannin | 2009 |
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Topics: Animals; Cell Line; Cell Movement; Epidermal Growth Factor; Fibroblast Growth Factor 1; Fibroblasts; Focal Adhesion Kinase 1; Insulin-Like Growth Factor I; Lysophospholipids; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, IGF Type 1; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection; Tyrosine | 2009 |
A regulatory mechanism for RSK2 NH(2)-terminal kinase activity.
Topics: Binding Sites; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Epidermal Growth Factor; Humans; Kaempferols; Kinetics; Lysine; Neoplasms; Phosphorylation; Protein Kinases; Recombinant Proteins; Reference Values; Ribosomal Protein S6 Kinases, 90-kDa; Skin; Tetradecanoylphorbol Acetate; Tissue Array Analysis; Valine | 2009 |
Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.
Topics: Adaptor Proteins, Signal Transducing; Alternative Splicing; Blotting, Western; Breast Neoplasms; Cell Movement; Cell Nucleus; DNA-Binding Proteins; Epidermal Growth Factor; Female; Fluorescent Antibody Technique; HeLa Cells; Humans; Hyaluronan Receptors; Immunoprecipitation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2009 |
Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.
Topics: Benzenesulfonates; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Group IV Phospholipases A2; HeLa Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Niacinamide; Phenylurea Compounds; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Sorafenib; src-Family Kinases; Temperature; Tetradecanoylphorbol Acetate; Time Factors | 2009 |
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification.
Topics: CDC2 Protein Kinase; Cell Cycle; Cells, Cultured; Cluster Analysis; Computational Biology; Cyclin B; Cyclin-Dependent Kinases; Epidermal Growth Factor; HeLa Cells; Humans; Insulin; Mass Spectrometry; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Reproducibility of Results; Signal Transduction; Tetradecanoylphorbol Acetate | 2009 |
The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.
Topics: Animals; Anti-Ulcer Agents; Blotting, Western; Carbenoxolone; Carcinogens; Carcinoma, Squamous Cell; Caveolin 1; Cell Communication; Cell Proliferation; Connexin 43; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epithelial Cells; Fluorescent Antibody Technique; Gap Junctions; Green Fluorescent Proteins; Humans; Immunoprecipitation; Keratinocytes; Mesoderm; Neoplasm Invasiveness; Rats; RNA, Small Interfering; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol ester by glycyrrhizin and carbenoxolone.
Topics: Carbenoxolone; Cell Line, Tumor; Drug Interactions; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Glycyrrhizic Acid; Humans; Mucin 5AC; Plant Extracts; Protein Synthesis Inhibitors; Respiratory Mucosa; Tetradecanoylphorbol Acetate | 2011 |
5'-Nitro-indirubinoxime inhibits epidermal growth factor- and phorbol ester-induced AP-1 activity and cell transformation through inhibition of phosphorylation of Pin1.
Topics: Animals; Anticarcinogenic Agents; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NIMA-Interacting Peptidylprolyl Isomerase; Oximes; Peptidylprolyl Isomerase; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation | 2011 |
Resveratrol inhibits mucin gene expression, production and secretion from airway epithelial cells.
Topics: Animals; Cell Line; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Humans; Male; Mucin 5AC; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Resveratrol; Stilbenes; Tetradecanoylphorbol Acetate; Trachea; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
Regulation of human thyroid follicular cell function by inhibition of vascular endothelial growth factor receptor signalling.
Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Humans; Insulin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organotechnetium Compounds; Phosphorylation; Plasminogen Activators; Protein Kinase C; Quinazolines; Rats; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Vascular Endothelial Growth Factor A | 2012 |
Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Topics: Animals; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Epithelial Cells; Gene Expression Regulation; Humans; Mucin 5AC; Rats; Reverse Transcriptase Polymerase Chain Reaction; Silybin; Silymarin; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary.
Topics: Animals; Carcinogens; Cell Cycle Checkpoints; Cell Cycle Proteins; Cells, Cultured; Chorionic Gonadotropin; Epidermal Growth Factor; Female; G1 Phase; Gene Expression Regulation, Enzymologic; Granulosa Cells; Humans; Promoter Regions, Genetic; Prostaglandins; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reproductive Control Agents; Resting Phase, Cell Cycle; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2012 |
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Angiotensin II; Blotting, Western; Cell Line, Tumor; EGF Family of Proteins; Enzyme Activation; Epidermal Growth Factor; Flow Cytometry; Glycoproteins; HEK293 Cells; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Jurkat Cells; Ligands; Phosphorylation; Protein Kinase C; Proteins; Proteolysis; RNA Interference; Serine; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 2013 |
Central role for protein kinase C in oxytocin and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells.
Topics: Cells, Cultured; Cyclooxygenase 2; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Myometrium; Oxytocin; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2014 |
Luteolin inhibited the gene expression, production and secretion of MUC5AC mucin via regulation of nuclear factor kappa B signaling pathway in human airway epithelial cells.
Topics: Cell Line; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Humans; Luteolin; Mucin 5AC; NF-kappa B; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetradecanoylphorbol Acetate | 2015 |
Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor.
Topics: Asparagus Plant; Cell Line, Tumor; Diosgenin; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Mucin 5AC; Plant Roots; Saponins; Tetradecanoylphorbol Acetate | 2015 |
PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736.
Topics: Calcineurin; Calcium; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Transformed; Epidermal Growth Factor; Gene Expression Regulation; Hemidesmosomes; Humans; Integrin alpha6beta4; Kalinin; Keratinocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Plectin; Protein Kinase C-delta; Protein Structure, Tertiary; Pteridines; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Tetradecanoylphorbol Acetate; Threonine; TRPP Cation Channels | 2015 |
A Signaling Network Controlling Androgenic Repression of c-Fos Protein in Prostate Adenocarcinoma Cells.
Topics: Adenocarcinoma; Androgens; Cell Death; Cell Line, Tumor; Dihydrotestosterone; Down-Regulation; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Metribolone; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostate; Prostatic Neoplasms; Protein Kinase C; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
Cellular and subcellular context determine outputs from signaling biosensors.
Topics: Biosensing Techniques; Cell Nucleus; Enzyme Activation; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fluorescence Resonance Energy Transfer; HEK293 Cells; HeLa Cells; Humans; MAP Kinase Signaling System; Receptors, G-Protein-Coupled; Signal Transduction; Tetradecanoylphorbol Acetate | 2016 |
Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins.
Topics: Animals; Caveolins; Cell Line; Chlorocebus aethiops; Clathrin; COS Cells; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; MAP Kinase Signaling System; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shc Signaling Adaptor Proteins; Tetradecanoylphorbol Acetate; Tyrphostins | 2016 |
Establishing a Proteomics-Based Monocyte Assay To Assess Differential Innate Immune Activation Responses.
Topics: Cell Line; Epidermal Growth Factor; Humans; Immunity, Innate; Lipopeptides; Monitoring, Immunologic; Monocytes; Proteome; Proteomics; Tetradecanoylphorbol Acetate | 2016 |
Dihydrocapsaicin Inhibits Epithelial Cell Transformation through Targeting Amino Acid Signaling and c-Fos Expression.
Topics: Amino Acids; Animals; Capsaicin; Cell Line; Cell Survival; Cyclooxygenase 2; Epidermal Growth Factor; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Gene Expression Regulation; Genes, fos; Humans; Mice; Molecular Structure; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; Tetradecanoylphorbol Acetate | 2019 |
Mitogen-induced transcriptional programming in human fibroblasts.
Topics: Cell Line; Cyclic AMP; Epidermal Growth Factor; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Genes, Immediate-Early; Humans; Isoquinolines; Mitogens; Reproducibility of Results; Ribosomal Protein S6 Kinases, 90-kDa; Sulfonamides; Tetradecanoylphorbol Acetate; Thionucleotides | 2021 |