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tetradecanoylphorbol acetate and eflornithine

tetradecanoylphorbol acetate has been researched along with eflornithine in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199017 (53.13)18.7374
1990's12 (37.50)18.2507
2000's3 (9.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Scott, RE; Wang, H1
DeBenedette, M; Snow, EC1
Byus, CV; Wu, VS1
Koyama, H; Matsui-Yuasa, I; Morii, H; Morisawa, S; Nishizawa, Y; Otani, S; Tahara, H1
Cantu, AR; Pavone, A; Reiners, JJ; Rupp, T1
Verma, AK1
Dröge, W; Mihm, S; Oberdorfer, F; Risso, A; Stöhr, M1
Baxter, CS; Petro, TM; Schuman, LD1
Ali, M; Duvick, L; Verma, AK1
Erickson, D; Verma, AK1
Matsui-Yuasa, I; Mimura, Y; Morisawa, S; Otani, S1
Dolnick, BJ; Erickson, D; Verma, AK1
Chenicek, KJ; DiGiovanni, J; Kruszewski, FH1
Kufe, DW; Shafman, T; Watanabe, T1
Jetten, AM; Shirley, JE1
Loprinzi, CL; Verma, AK1
Griffin, JD; Kufe, DW; Larcom, P1
Ashendel, CL; Boutwell, RK; Takigawa, M; Verma, AK1
Boutwell, RK; Simsiman, RC; Takigawa, M; Verma, AK2
Griffin, J; Kufe, DW; Mitchell, T; Shafman, T1
Iwashima, A; Oku, T; Yamanishi, K1
Herrmann, AL; Nelson, FR; Slaga, TJ; Weeks, CE1
Hickok, NJ; Jänne, OA; Pomidor, MM; Ruhl, KK; Song, Y; Tuan, RS; Zheng, P1
Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N1
Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G1
Gilmour, SK; Smith, MK; Trempus, CS1
Bomser, JA; Singletary, KW; Smith, MA; Wallig, MA1
Colburn, NH; Jansen, AP; Verma, AK1
Bastida, CM; Garcija-Borron, JC; Martijnez-Esparza, M; Penafiel, R; Sanchez Mas, J; Solano, F1
Dreckschmidt, NE; Leitges, M; Reddig, PJ; Verma, AK; Wheeler, DL1
Ness, KJ; Oberley, TD; Verma, AK; Wheeler, DL1

Reviews

2 review(s) available for tetradecanoylphorbol acetate and eflornithine

ArticleYear
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
    Basic life sciences, 1990, Volume: 52

    Topics: Animals; Carcinogens; Colonic Neoplasms; Eflornithine; Female; Mammary Neoplasms, Experimental; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate

1990
Observations on the mechanism of skin tumor promotion by phorbol esters.
    Princess Takamatsu symposia, 1983, Volume: 14

    Topics: Adenosylmethionine Decarboxylase; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate

1983

Trials

1 trial(s) available for tetradecanoylphorbol acetate and eflornithine

ArticleYear
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
    Journal of the National Cancer Institute, 1993, May-05, Volume: 85, Issue:9

    Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine Decarboxylase; Prostatic Neoplasms; Skin; Tetradecanoylphorbol Acetate; Urinary Bladder Neoplasms

1993

Other Studies

29 other study(ies) available for tetradecanoylphorbol acetate and eflornithine

ArticleYear
Induction of c-jun independent of PKC, pertussis toxin-sensitive G protein, and polyamines in quiescent SV40-transformed 3T3 T cells.
    Experimental cell research, 1992, Volume: 203, Issue:1

    Topics: 3T3 Cells; Alkaloids; Animals; Antigens, Polyomavirus Transforming; Cell Division; Cell Line, Transformed; Eflornithine; Gene Expression; Genes, jun; Genistein; GTP-Binding Proteins; Insulin; Isoflavones; Kinetics; Mice; Pertussis Toxin; Polyamines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Putrescine; Signal Transduction; Simian virus 40; Spermidine; Staurosporine; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella

1992
Induction and regulation of casein kinase II during B lymphocyte activation.
    Journal of immunology (Baltimore, Md. : 1950), 1991, Nov-01, Volume: 147, Issue:9

    Topics: Animals; B-Lymphocytes; Bucladesine; Calcium; Casein Kinases; Cell Cycle; Cycloheximide; Eflornithine; Enzyme Induction; Female; Ionomycin; Lymphocyte Activation; Lymphocyte Cooperation; Male; Mice; Mice, Inbred DBA; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Kinase C; Protein Kinases; T-Lymphocytes, Helper-Inducer; Tetradecanoylphorbol Acetate

1991
The level of substrate ornithine can alter polyamine-dependent DNA synthesis following phorbolester stimulation of cultured hepatoma cells.
    Journal of cellular physiology, 1991, Volume: 149, Issue:1

    Topics: Animals; Arginine; Blood; Clone Cells; Culture Media; DNA; Eflornithine; Insulin; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1991
Role of putrescine in interleukin 1 beta production in human histiocytic lymphoma cell line U937.
    Journal of cellular physiology, 1991, Volume: 147, Issue:2

    Topics: Calcitriol; Cell Differentiation; Cell Division; Eflornithine; Humans; Interleukin-1; Kinetics; Lipopolysaccharides; Lymphoma, Large B-Cell, Diffuse; Monocytes; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1991
Modulation of the co-promoting activity of gamma interferon in SENCAR and C57BL/6 mouse skin by difluoromethylornithine and the scheduling and duration of interferon treatment.
    Carcinogenesis, 1990, Volume: 11, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Eflornithine; Female; Interferon-gamma; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Recombinant Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate

1990
Downregulation of T cell growth factor production by ornithine decarboxylase and its product putrescine: D,L-alpha-difluoromethylornithine suppresses general protein synthesis but augments simultaneously the production of interleukin-2.
    Experimental cell research, 1989, Volume: 180, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Cell Line; Eflornithine; Glycolysis; Interleukin-2; Intracellular Fluid; Leucine; Lymphoma; Mice; Mitosis; Ornithine Decarboxylase; Protein Synthesis Inhibitors; Putrescine; RNA, Messenger; Tetradecanoylphorbol Acetate

1989
Effect of the ornithine decarboxylase inhibitor alpha, alpha-difluoromethylornithine on phorbol diester-induced inhibition of murine B lymphocyte differentiation.
    Cancer letters, 1989, Sep-15, Volume: 47, Issue:1-2

    Topics: Animals; Antibody Formation; B-Lymphocytes; Biogenic Polyamines; Cell Differentiation; Eflornithine; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ornithine Decarboxylase Inhibitors; Tetradecanoylphorbol Acetate

1989
Modulation of mouse skin tumor promotion by dietary 13-cis-retinoic acid and alpha-difluoromethylornithine.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: Animals; Diet; Eflornithine; Female; Isotretinoin; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin

1986
Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate: dependence on calcium availability.
    Archives of biochemistry and biophysics, 1986, Volume: 247, Issue:2

    Topics: Animals; Autoradiography; Calcimycin; Calcium; Chemical Precipitation; Densitometry; Eflornithine; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Mice; Nucleic Acid Hybridization; Ornithine; Ornithine Decarboxylase; Phorbols; Protein Binding; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate

1986
Potentiation by retinoic acid of ornithine decarboxylase induction by phytohemagglutinin or phorbol 12-myristate 13-acetate in guinea pig lymphocytes.
    Journal of biochemistry, 1986, Volume: 99, Issue:6

    Topics: Animals; Diterpenes; DNA; Drug Synergism; Eflornithine; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Leucine; Lymphocytes; Ornithine; Ornithine Decarboxylase; Phorbols; Phytohemagglutinins; Polyamines; Retinyl Esters; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A

1986
Increased mouse epidermal ornithine decarboxylase activity by the tumour promoter 12-O-tetradecanoylphorbol 13-acetate involves increased amounts of both enzyme protein and messenger RNA.
    The Biochemical journal, 1986, Jul-01, Volume: 237, Issue:1

    Topics: Animals; Eflornithine; Enzyme Induction; Epidermis; Female; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate

1986
Modulation of chrysarobin skin tumor promotion.
    Carcinogenesis, 1988, Volume: 9, Issue:8

    Topics: Animals; Anthracenes; Carcinogens; Cocarcinogenesis; Eflornithine; Female; Fluocinolone Acetonide; Mice; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin

1988
Requirement of spermidine for induction of both heme synthesis and globin transcription in murine erythroleukemia cells.
    Journal of cellular physiology, 1985, Volume: 122, Issue:3

    Topics: Animals; Cell Division; Dexamethasone; Dimethyl Sulfoxide; Eflornithine; Globins; Heme; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Spermidine; Tetradecanoylphorbol Acetate; Transcription, Genetic

1985
Retinoids antagonize the induction of ornithine decarboxylase activity by phorbol esters and phospholipase C in rat tracheal epithelial cells.
    Journal of cellular physiology, 1985, Volume: 123, Issue:3

    Topics: Animals; Cycloheximide; Eflornithine; Epithelial Cells; Epithelium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Phorbols; Phospholipases; Rats; Receptors, Drug; Retinoids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Trachea; Type C Phospholipases

1985
Inhibition of ornithine decarboxylase activity by small doses of alpha-difluoromethylornithine.
    Cancer letters, 1985, Sep-30, Volume: 28, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Eflornithine; Kidney; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Skin; Tetradecanoylphorbol Acetate

1985
TPA induces differentiation of purified human myeloblasts in the absence of proliferation.
    Experimental hematology, 1985, Volume: 13, Issue:10

    Topics: Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Division; Colony-Stimulating Factors; DNA Replication; Eflornithine; Hematopoietic Stem Cells; Humans; Ornithine; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate; Thymidine; Tritium

1985
Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine.
    Cancer research, 1983, Volume: 43, Issue:8

    Topics: Adenosylmethionine Decarboxylase; Administration, Oral; Administration, Topical; Animals; Cell Division; Eflornithine; Epidermis; Female; Injections, Intraperitoneal; Mice; Ornithine; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate

1983
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kinetics; Leukemia, Myeloid, Acute; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Spermidine; Tetradecanoylphorbol Acetate

1984
Role of polyamine synthesis in the stimulation of hexose transport by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate in cultured mouse fibroblasts.
    Cell biology international reports, 1984, Volume: 8, Issue:8

    Topics: Animals; Cells, Cultured; Deoxyglucose; Eflornithine; Epidermal Growth Factor; Fibroblasts; Hexoses; Mice; Ornithine; Polyamines; Putrescine; Tetradecanoylphorbol Acetate

1984
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
    Biochemical and biophysical research communications, 1982, Apr-14, Volume: 105, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate

1982
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:19

    Topics: Alkynes; Animals; Antineoplastic Agents, Phytogenic; Carboxy-Lyases; Carcinogens; Diterpenes; Eflornithine; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Polyamines; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate

1982
Relationship between ornithine decarboxylase and cytoskeletal organization in cultured human keratinocytes: cellular responses to phorbol esters, cytochalasins, and alpha-difluoromethylornithine.
    Experimental cell research, 1995, Volume: 221, Issue:2

    Topics: Actins; Antibody Specificity; Cell Division; Cell Nucleus; Cell Size; Cells, Cultured; Cytochalasin B; Cytochalasin D; Cytoskeleton; Eflornithine; Enzyme Inhibitors; Humans; Keratinocytes; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Tetradecanoylphorbol Acetate

1995
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured

1993
Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin.
    Carcinogenesis, 1998, Volume: 19, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Carcinogens; Eflornithine; Genes, ras; Keratoacanthoma; Mice; Mice, Transgenic; Ornithine Decarboxylase; Papilloma; Proliferating Cell Nuclear Antigen; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate

1998
Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds.
    Cancer letters, 1999, Jan-29, Volume: 135, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthocyanins; Carcinogens; Drug Screening Assays, Antitumor; Eflornithine; Enzyme Inhibitors; Female; Flavonoids; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peroxidase; Phenols; Polymers; Proanthocyanidins; Rosales; Seeds; Skin Neoplasms; Tetradecanoylphorbol Acetate

1999
Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation.
    Oncogene, 1999, Oct-14, Volume: 18, Issue:42

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

1999
Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
    Biochimica et biophysica acta, 2002, Jan-30, Volume: 1542, Issue:1-3

    Topics: alpha-MSH; Animals; Cell Line; Eflornithine; Enzyme Activation; Gene Expression Regulation, Enzymologic; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation

2002
Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.
    Oncogene, 2002, May-16, Volume: 21, Issue:22

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Cycle Proteins; Cell Division; Eflornithine; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epidermis; Female; Isoenzymes; Kinetics; Male; Mice; Mice, Knockout; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Kinase C; Protein Kinase C-delta; RNA, Messenger; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins

2002
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
    Cancer research, 2003, Jun-15, Volume: 63, Issue:12

    Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Eflornithine; Enzyme Inhibitors; Epidermis; Hair Follicle; Isoenzymes; Mice; Mice, Transgenic; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Kinase C; Protein Kinase C-epsilon; Putrescine; Recombinant Fusion Proteins; Skin Neoplasms; Skin Ulcer; Tetradecanoylphorbol Acetate

2003