tetradecanoylphorbol acetate has been researched along with bryostatin 1 in 169 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (13.61) | 18.7374 |
| 1990's | 109 (64.50) | 18.2507 |
| 2000's | 29 (17.16) | 29.6817 |
| 2010's | 8 (4.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Irie, K; Kamachi, H; Murakami, A; Nagai, H; Nakagawa, Y; Tanaka, K; Tokuda, H; Yanagita, RC | 1 |
| Blumberg, PM; Keck, GE; Kedei, N; Lewin, NE; Poudel, YB; Rudra, A; Stephens, JC | 1 |
| Blumberg, PM; Herald, CL; Keck, GE; Kedei, N; Kraft, MB; Melody, N; Pettit, GR | 1 |
| Pitha, PM; Vlach, J | 1 |
| Gschwendt, M; Kittstein, W; Lindner, D; Marks, F | 1 |
| Drexler, HG; Gignac, SM; Grunicke, D; Pettit, GR; Pietsch, T; Steube, KG | 1 |
| Hamilton, SE; Hemphill, JE; Lavin, MF; Michael, J; Pettit, GR; Watters, DJ | 1 |
| Deli, E; Kiss, Z | 1 |
| Fields, AP; Hocevar, BA; Morrow, DM; Tykocinski, ML | 1 |
| Bradshaw, TD; Gescher, A; Pettit, GR | 2 |
| Basu, A; Lazo, JS | 1 |
| Drexler, HG; Gignac, SM; Hoffbrand, AV; Pettit, GR | 1 |
| Ciccarelli, A; Cirillo, R; Condorelli, M; Marone, G; Pettit, GR; Siri, L; Triggiani, M | 1 |
| Buschle, M; Drexler, HG; Gignac, SM; Hoffbrand, AV | 1 |
| Baker, MA; Civin, CI; Fackler, MJ; May, WS; Sutherland, DR | 1 |
| Davidson, NE; Kennedy, MJ; May, WS; Prestigiacomo, LJ; Tyler, G | 1 |
| Kraft, AS; Tilden, AB | 1 |
| Hess, AD; Levine, BL; May, WS; Tyler, PG | 1 |
| Mackanos, EA; Pettit, GR; Ramsdell, JS | 1 |
| Harris, AL; Lunec, J; Nutt, JE | 1 |
| Abboud, CN; Lichtman, MA; Packman, CH; Sham, RL | 2 |
| Esa, AH; Hess, AD; Laulis, MK; May, S; Pettit, GR; Schuchter, LM | 1 |
| Chattopadhyay, J; Kiss, Z; Pettit, GR | 1 |
| Datta, R; Kufe, D; Sherman, ML; Stone, RM | 1 |
| Brown, C; Kraft, A; Lilly, M; Pettit, G | 1 |
| Anderson, WB; Kiss, Z; Pettit, GR; Rapp, UR | 1 |
| Child, JA; Drexler, HG; Gignac, SM; Jones, RA; Scott, CS | 1 |
| Buschie, M; Drexler, HG; Gignac, SM; Hoffbrand, AV; Pettit, GR | 1 |
| Fields, AP; Kraft, AS; May, WS; Tyler, G | 1 |
| Brachwitz, H; Langen, P; Maidhof, A; Matthes, E; Müller, WE; Renneisen, K; Schröder, HC; Weiler, BE | 1 |
| Fauci, AS; Folks, TM; Kinter, AL; Maury, W; Poli, G | 1 |
| Adler, WH; Boto, WO; Esa, AH; Hess, AD; May, WS | 1 |
| McBain, JA; Mueller, GC; Pettit, GR | 2 |
| Akerlind, G; Akerman, KE; Heikkilä, J; Jalava, AM; Pettit, GR | 1 |
| Housey, GM; Kraft, AS; Wagner, F | 1 |
| Fürstenberger, G; Gschwendt, M; Herald, CL; Kittstein, W; Marks, F; Pettit, GR; Rogers, M; Rose-John, S | 1 |
| George, MA; Herald, CL; Jetten, AM; Pettit, GR; Rearick, JI | 1 |
| Drexler, HG; Gignac, SM; Hoffbrand, AV; Jones, RA; Pettit, GR; Scott, CS | 1 |
| Chen, TH; Gagucas, R; Membreño, L; Shoback, D; Woodley, S | 1 |
| George, MA; Jetten, AM; Pettit, GR; Rearick, JI | 1 |
| Bradshaw, TD; Dale, IL; Gescher, A; Pettit, GR | 1 |
| Blumberg, PM; Herald, CL; Pettit, GR; Sako, T; Yuspa, SH | 1 |
| Dale, IL; Gescher, A | 1 |
| Berkow, RL; Kraft, AS | 1 |
| Smith, JB; Tallant, EA; Wallace, RW | 1 |
| Deli, E; Girard, PR; Kiss, Z; Kuo, JF; Pettit, GR | 1 |
| Garrison, JC; Pettit, GR; Uyeki, EM | 1 |
| Mohr, H; Pettit, GR; Plessing-Menze, A | 1 |
| Daniel, LW; Parker, J; Pettit, GR; Waite, M | 1 |
| Deli, E; Kiss, Z; Kuo, JF | 1 |
| Ohshima, S; Sako, T; Sakurai, M; Yoshizumi, T | 1 |
| Esa, AH; Hess, AD; May, WS; Pettit, GR; Silanskis, MK | 1 |
| Baker, VV; Kraft, AS; May, WS | 1 |
| Pettit, GR; Ramsdell, JS; Tashjian, AH | 1 |
| Deli, E; Kiss, Z; Koeffler, HP; Kuo, JF; Pettit, GR; Shoji, M; Vogler, WR | 1 |
| Blumberg, PM; Hennings, H; Herald, CL; Pettit, GR; Shores, R; Yuspa, SH | 1 |
| Pettit, GR; Smith, JB; Smith, L | 1 |
| Casolaro, V; de Paulis, A; Guidi, G; Marino, O; Marone, G; Meliota, S; Patella, V | 1 |
| Gschwendt, M; Kielbassa, K; Kittstein, W; Marks, F | 2 |
| Casolaro, V; Ciccarelli, A; Columbo, M; Marone, G; Patella, V; Pettit, GR | 1 |
| Bryant, WO; Chen, J; Cook, PP; de Vente, JE; Fletcher, DJ; Kukoly, CA; Lozano, G; Parker, PJ; Pettit, GJ; Posekany, KJ | 1 |
| Burns, DJ; Fields, AP; Murray, NR; Walker, SD | 1 |
| Geiges, D; Gschwendt, M; Marks, F | 1 |
| Asiedu, C; Biggs, J; Kraft, AS; Lilly, M | 1 |
| Dickson, RB; Johnson, GR; Martínez-Lacaci, I; Normanno, N; Plowman, GD; Saceda, M; Salomon, DS | 1 |
| Dexter, TM; Heyworth, CM; Nicholls, SE; Whetton, AD | 1 |
| Akompong, T; Schonhorn, JE; Wessling-Resnick, M | 1 |
| Drexler, HG; Hu, ZB; Lanotte, M; Ma, W; Uphoff, CC | 1 |
| Courage, C; Crowther, D; Dickson, AJ; Fox, BW; Gescher, A; McGown, AT; Pettit, GR; Prendiville, J | 1 |
| Doppler, W; Grunicke, HH; Kampfer, S; Schubert, C; Uberall, F | 1 |
| Drexler, HG; Grunicke, D; Steube, KG | 1 |
| Blumberg, PM; Denning, MF; Dlugosz, AA; Pettit, GR; Smith, CB; Szallasi, Z; Yuspa, SH | 1 |
| Gschwendt, M; Kielbassa, K; Marks, F; Müller, HJ; Zang, R | 1 |
| Baldassare, JJ; Ballas, LM; Burns, DJ; Fisher, GJ; Henderson, PA; Moomaw, CR; Reynolds, NJ; Shuler, JL | 1 |
| Call, KM; Lindberg, C; Phelan, SA | 1 |
| Altman, A; Galron, D; Isakov, N; Tamir, A | 1 |
| Akhtar, A; al-Katib, A; Dan, M; Hussein, ME; Mohammad, RM; Pettit, GR; Sensenbrenner, LL | 1 |
| Bernacki, SH; Jetten, AM; Saunders, NA; Vollberg, TM | 1 |
| Bradshaw, TD; Gescher, A; Pettit, GR; Stanwell, C | 1 |
| Galron, D; Gelkop, S; Grossman, N; Isakov, N; Tamir, A | 1 |
| Lieberman, MA; Namciu, S; Stavnezer, E | 1 |
| DeLeo, VA; Illarda, I; Matsui, MS; Wang, N | 1 |
| Drexler, HG; Hu, ZB; Ma, W; Uphoff, CC | 1 |
| Arrand, JR; Fox, BW; McGown, AT; Pettit, GR; Prendiville, J; Stewart, JP | 1 |
| Bond, J; Dawson, T; Eccles, N; Wynford-Thomas, D | 1 |
| Campbell, XZ; Fields, AP; Neet, KE; Singh, KR; Taylor, LK | 1 |
| Blumberg, PM; Pettit, GR; Smith, CB; Szallasi, Z | 1 |
| al-Katib, A; Dan, ME; Khan, K; Mohammad, RM; Pettit, GR; Sensenbrenner, LL | 1 |
| Drexler, HG; Grunicke, D; Quentmeier, H; Steube, KG | 1 |
| Grabarek, J; Ware, JA | 1 |
| Heikkilä, J; Jalava, A; Lintunen, M | 1 |
| Drexler, HG; Steube, KG | 1 |
| Akerman, K; Heikkilä, J; Jalava, A | 1 |
| Campbell, XZ; Neet, KE | 1 |
| Harris, AL; Philip, PA | 1 |
| Converse, PJ; Esa, AH | 1 |
| Carey, JO; deVente, JE; Pettit, GR; Posekany, KJ; Ways, DK | 1 |
| Boyan, BD; Dean, DD; Ellis, EB; Gomez, R; Helm, SH; Schwartz, Z; Sylvia, VL | 1 |
| Billet, H; Fuchs, A; Gartenhaus, R; Gentile, P; Hoffman, M; Rai, K; Wang, P | 1 |
| Bingham Smith, J; Lee, HW; Pettit, GR; Smith, L | 1 |
| Ciccarelli, A; Cirillo, R; de Crescenzo, G; de Paulis, A; Marone, G; Patella, V | 1 |
| Eastman, A; McBain, JA; Mueller, GC; Pettit, GR; Simmons, DL | 1 |
| Columbo, M; Horowitz, EM; Kagey-Sobotka, A; Lichtenstein, LM | 1 |
| Deed, R; Hirose, T; Murphy, JJ; Newton, J; Ning, ZQ; Norton, JD | 1 |
| Hansen, H; Riedel, H; Shieh, HL; Zhu, J | 1 |
| Bryant, WO; Carey, JO; deVente, JE; Pettit, GJ; Ways, DK | 1 |
| Lee, HW; Pettit, GR; Smith, JB; Smith, L | 1 |
| Davis, AF; Meighan-Mantha, RL; Riegel, AT | 1 |
| Foster, DA; Hornia, A; Jiang, YW; Lu, Z; Ohno, S; Zang, Q | 1 |
| Ansotegui, IJ; Galron, D; Isakov, N | 1 |
| Matthews, SA; Pettit, GR; Rozengurt, E | 1 |
| Fischer, SM; Hagerman, RA; Locniskar, MF | 1 |
| Goode, N; Keenan, C; Pears, C | 1 |
| Chelliah, J; Freemerman, AJ; Grant, S; Jarvis, WD; Wu-Pong, S | 1 |
| Acs, P; Blumberg, PM; Bögi, K; Lorenzo, PS; Pettit, GR | 1 |
| Crowther, D; Haran, MS; Jayson, G; McGown, AT; Pettit, GR; Ward, TH | 1 |
| Byers, DM; Cook, HW; Ridgway, ND | 1 |
| Grant, S; Jarvis, WD; Rao, AS; Vrana, JA; Wang, Z | 1 |
| Denning, MF; Ellerbroek, SM; Green, KJ; Guy, SG; Kowalczyk, AP; Norvell, SM | 1 |
| Ekinci, FJ; Shea, TB | 1 |
| Boorne, AJ; Donnelly, N; Schrey, MP | 1 |
| Chellappan, SP; Grant, S; Saunders, AM; Vrana, JA | 1 |
| Farokhzad, OC; Matthews, JB; Mun, EC; Sicklick, JK; Smith, JA | 1 |
| Ho, C; Kelly, MB; Mazurek, A; Milano, SK; Slater, SJ; Stagliano, BA; Stubbs, CD; Taddeo, FJ | 1 |
| Fisher, PB; Grant, S; Su, ZZ; VanTuyle, G; Wang, S; Wang, Z | 1 |
| Acs, P; Baskin, L; Blumberg, PM; Bogi, K; Brodie, C; Lorenzo, PS | 1 |
| Norman, AW; Song, XD | 1 |
| Dickson, RB; Johnson, MD; Lippman, ME; Torri, JA | 1 |
| Dent, P; Grant, S; Kramer, LB; Povirk, LF; Saunders, AM; Vrana, JA; Zhang, XF | 1 |
| Comb, MJ; Demeter, MR; Ruan, H; Tan, Y | 1 |
| Bhattacharyya, D; Blumberg, PM; Garfield, S; Marquez, VE; Nacro, K; Wang, QJ | 1 |
| Comolli, R; Di Dio, A; La Porta, CA; Porro, D | 1 |
| Fair, WR; Gschwend, JE; Powell, CT | 1 |
| Chen, L; Diasio, RB; Johnson, MR; Smith, JB; Smith, L; Wang, K | 1 |
| Häussermann, S; Marks, F; Rennecke, J; Richter, KH; Stempka, L; Stöhr, M; Strand, S | 1 |
| Clarke, H; Ginanni, N; Laughlin, KV; Mullin, JM; Pettit, GR; Smith, JB | 1 |
| Meinhardt, G; Roth, J; Totok, G | 1 |
| Grant, S; Vrana, JA | 1 |
| Lee, RG; Rosson, D | 1 |
| Farokhzad, OC; Hanson, CM; Lotz, M; Matthews, JB; Song, JC; Tsai, V | 1 |
| Comolli, R; La Porta, CA | 1 |
| Matthews, JB; Mun, EC; Nichols, A; Song, JC; Yoo, J | 1 |
| Borchert-Stuhlträger, M; Dietrich, C; Faust, D; Heit, I; Herget, T; Oesch, F; Wieser, RJ | 1 |
| Cidlowski, JA; Gómez-Angelats, M | 1 |
| Conrad, DH; Grant, S; Ma, C; Rabah, D | 1 |
| Lange, Y; Steck, TL; Ye, J | 1 |
| González, MI; Kazanietz, MG; Robinson, MB | 1 |
| Bhatnagar, A; Liu, SQ; May, WS; Ruvolo, PP; Thongboonkerd, V; Varma, T; West, M | 1 |
| Black, JD; Leontieva, OV | 1 |
| Blois, JT; Chiles, TC; Mataraza, JM; Mecklenbraüker, I; Tarakhovsky, A | 1 |
| Baryza, JL; Brenner, SE; Dower, NA; Stang, SL; Stone, JC; Wender, PA; Zheng, Y | 1 |
| Basu, A; Huang, J; Mohanty, S | 1 |
| Hadjab, S; Hans, G; Lallemend, F; Lefebvre, PP; Malgrange, B; Moonen, G | 1 |
| Powell, CT; Yin, L | 1 |
| Lorenzo, PS; Oki, CE; Tuthill, MC | 1 |
| Blumberg, PM; Choi, SH; Hyman, T | 1 |
| Adler, KB; Crews, AL; Fang, S; Lampe, WR; Park, J; Park, JA | 1 |
| Blumberg, PM; Keck, GE; Kedei, N; Kraft, MB; Lewin, NE; Li, W; Sanchez, CC; Truong, AP | 1 |
| Alexander, JS; Carpenter, AC | 1 |
| Blumberg, PM; Keck, GE; Kedei, N; Kraft, MB; Lewin, NE; Li, W | 1 |
| Kazanietz, MG; von Burstin, VA; Xiao, L | 1 |
| Blumberg, PM; Chen, J; Czap, A; Czifra, G; Garfield, SH; Goldsmith, PK; Keck, GE; Kedei, N; Kraft, MB; Li, W; Lim, L; Lubart, ES; Mannan, P; Morrison, T; Telek, A; Yang, D | 1 |
| Bullen, CK; Durand, CM; Laird, GM; Siliciano, JD; Siliciano, RF | 1 |
| Andrews, IP; Blumberg, PM; Kedei, N; Ketcham, JM; Krische, MJ; Lewin, NE; Peach, ML | 1 |
| Hongbo, T; Wu, M; Wu, Y; Xu, Y; Zeng, N | 1 |
2 review(s) available for tetradecanoylphorbol acetate and bryostatin 1
| Article | Year |
|---|---|
Differentiation and growth modulation of myeloid leukemia cells by the protein kinase C activating agent bryostatin-1.
Topics: Antineoplastic Agents; Bryostatins; Cell Differentiation; Cell Division; Dexamethasone; Drug Interactions; Enzyme Activation; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Lactones; Leukemia, Myeloid; Macrolides; Neoplastic Stem Cells; Protein Kinase C; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Potential for protein kinase C inhibitors in cancer therapy.
Topics: Animals; Antineoplastic Agents; Bryostatins; DNA Topoisomerases, Type I; Drug Resistance; Enzyme Inhibitors; Humans; Lactones; Macrolides; Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate | 1995 |
167 other study(ies) available for tetradecanoylphorbol acetate and bryostatin 1
| Article | Year |
|---|---|
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxyl Radical; Lyngbya Toxins; Neoplasms; Protein Kinase C | 2010 |
Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Topics: Antineoplastic Agents; Bryostatins; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Humans; Isoenzymes; Molecular Structure; Protein Kinase C; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2012 |
Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.
Topics: Animals; Bryostatins; Bryozoa; Humans; Models, Molecular; Molecular Structure; Phorbol Esters; Protein Kinase C | 2015 |
Activation of human immunodeficiency virus type 1 provirus in T-cells and macrophages is associated with induction of inducer-specific NF-kappa B binding proteins.
Topics: Blotting, Northern; Blotting, Western; Bryostatins; Cell Line; Gene Expression Regulation, Viral; HIV-1; Kinetics; Lactones; Macrolides; Macrophages; NF-kappa B; Phytohemagglutinins; Proviruses; RNA-Directed DNA Polymerase; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virus Activation | 1992 |
Differential inhibition by staurosporine of phorbol ester, bryostatin and okadaic acid effects on mouse skin.
Topics: Alkaloids; Animals; Bryostatins; Cyclosporine; Edema; Ethers, Cyclic; Female; Lactones; Macrolides; Mice; Okadaic Acid; Protein Kinase C; Skin; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.
Topics: Antineoplastic Agents; Bryostatins; Cell Differentiation; Cell Division; Depsipeptides; Humans; In Vitro Techniques; Lactones; Leukemia; Macrolides; Oligopeptides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Bistratene A: a novel compound causing changes in protein phosphorylation patterns in human leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Bryostatins; Ethers, Cyclic; Humans; Lactones; Leukemia; Macrolides; Neoplasm Proteins; Phosphorylation; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Alkaloids; Animals; Bryostatins; Down-Regulation; Drug Interactions; Ethers, Cyclic; Hydrolysis; Lactones; Macrolides; Mice; Okadaic Acid; Phosphatidylethanolamines; Phospholipase D; Phospholipids; Platelet-Derived Growth Factor; Protein Kinase C; Sphingomyelin Phosphodiesterase; Sphingosine; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation.
Topics: Bryostatins; Cell Division; Enzyme Activation; Erythropoiesis; Humans; Immunoblotting; Isoenzymes; Kinetics; Lactones; Lamins; Leukemia, Erythroblastic, Acute; Macrolides; Nuclear Proteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Modulation by staurosporine of phorbol-ester-induced effects on growth and protein kinase C localization in A549 human lung-carcinoma cells.
Topics: Alkaloids; Bryostatins; Cell Division; DNA; Down-Regulation; Enzyme Activation; Humans; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum(II) by bryostatin 1.
Topics: Antineoplastic Agents; Biological Transport; Bryostatins; Cell Division; Cell Line; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Head and Neck Neoplasms; HeLa Cells; Humans; Isoenzymes; Kinetics; Lactones; Macrolides; Organoplatinum Compounds; Phorbol 12,13-Dibutyrate; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibody Formation; B-Lymphocytes; Bryostatins; Calcimycin; Cell Cycle; Cyclosporins; DNA; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Lactones; Lymphocyte Activation; Macrolides; Piperazines; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate | 1990 |
Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin.
Topics: Antibodies, Anti-Idiotypic; Basophils; Bryostatins; Calcimycin; Calcium; Carrier Proteins; Cyclosporins; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Lactones; Macrolides; Peptidylprolyl Isomerase; SRS-A; Tetradecanoylphorbol Acetate | 1990 |
Down-regulation of CD5 mRNA in B-chronic lymphocytic leukemia cells by differentiation-inducing agents.
Topics: Aged; Antigens, CD; Antigens, Differentiation; Bryostatins; Calcimycin; CD5 Antigens; Cell Differentiation; Female; Gene Expression Regulation, Neoplastic; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells.
Topics: Antigens, CD; Antigens, CD34; Antigens, Differentiation; Blotting, Western; Bryostatins; Enzyme Activation; Flow Cytometry; Growth Substances; Hematopoietic Stem Cells; Humans; Lactones; Macrolides; Molecular Weight; Peptide Mapping; Phosphorylation; Phosphoserine; Protein Kinase C; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate | 1990 |
The effect of fetal calf serum on growth arrest caused by activators of protein kinase C.
Topics: alpha-Fetoproteins; Animals; Antineoplastic Agents; Blood; Bryostatins; Cattle; Cell Division; Culture Media; DNA Replication; Enzyme Activation; Epidermal Growth Factor; Humans; Kinetics; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tretinoin | 1991 |
Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.
Topics: Breast Neoplasms; Bryostatins; Cell Division; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Isoenzymes; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
The effect of bryostatin 1 on human lymphocyte-mediated cytotoxicity.
Topics: Antibody-Dependent Cell Cytotoxicity; Antigens, Differentiation; Bryostatins; Cells, Cultured; Enzyme Activation; Fluorescent Antibody Technique; Humans; Interleukin-2; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lactones; Lymphocytes; Macrolides; Protein Kinase C; Receptors, Fc; Receptors, IgG; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1991 |
Response of Jurkat T cells to phorbol ester and bryostatin. Development of sublines with distinct functional responses and changes in protein kinase C activity.
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bryostatins; CD3 Complex; Clone Cells; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Humans; In Vitro Techniques; Lactones; Lymphocyte Activation; Macrolides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Adhesion; Cell Cycle; Cell Division; Cell Line; DNA Replication; Epidermal Growth Factor; Kinetics; Lactones; Macrolides; Pituitary Neoplasms; Protein Kinase C; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine; Thyrotropin-Releasing Hormone | 1991 |
Phorbol ester and bryostatin effects on growth and the expression of oestrogen responsive and TGF-beta 1 genes in breast tumour cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Bryostatins; Cell Division; Culture Media; Estradiol; Gene Expression Regulation, Neoplastic; Lactones; Macrolides; Neoplasm Proteins; Proteins; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Thymidine; Transforming Growth Factor beta; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1991 |
Signal transduction and the regulation of actin conformation during myeloid maturation: studies in HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Bryostatins; Calcium; Cell Differentiation; Dimethyl Sulfoxide; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Lactones; Macrolides; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Successful treatment of murine melanoma with bryostatin 1.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cytotoxicity, Immunologic; Female; Killer Cells, Lymphokine-Activated; Lactones; Lung Neoplasms; Macrolides; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Spleen; Tetradecanoylphorbol Acetate | 1991 |
Stimulation of phosphatidylcholine synthesis by activators of protein kinase C is dissociable from increased phospholipid hydrolysis.
Topics: Animals; Bryostatins; Cells, Cultured; Enzyme Activation; Fibroblasts; Hydrolysis; Ionomycin; Lactones; Leukemia, Experimental; Macrolides; Phosphatidylcholines; Phospholipids; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1991 |
Expression of the jun-B gene during induction of monocytic differentiation.
Topics: Bryostatins; Calcitriol; Cell Differentiation; DNA-Binding Proteins; Gene Expression; Humans; Lactones; Leukemia, Myeloid; Macrolides; Monocytes; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1991 |
Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia.
Topics: Antineoplastic Agents; Bryostatins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lactones; Leukemia, Myelomonocytic, Chronic; Macrolides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tumor Stem Cell Assay | 1991 |
Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Bryostatins; Cell Line; Cell Transformation, Neoplastic; Genes, ras; Guanosine 5'-O-(3-Thiotriphosphate); Hydrolysis; Kinetics; Lactones; Macrolides; Mice; Mice, Inbred Strains; Oncogene Proteins v-raf; Oncogenes; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Protein-Tyrosine Kinases; Retroviridae Proteins, Oncogenic; Rubidium; Tetradecanoylphorbol Acetate | 1991 |
In vitro beta 2-microglobulin (beta 2m) secretion by normal and leukaemic B-cells: effects of recombinant cytokines and evidence for a differential response to the combined stimulus of phorbol ester and calcium ionophore.
Topics: Adjuvants, Immunologic; B-Lymphocytes; beta 2-Microglobulin; Biological Factors; Bryostatins; Calcimycin; Cytokines; Humans; Immunoglobulin M; Lactones; Leukemia, B-Cell; Macrolides; Mitogens; Recombinant Proteins; Reference Values; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bryostatins; Calcimycin; Cell Differentiation; Enzyme Activation; Gene Expression; Humans; Isoquinolines; Kinetics; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Piperazines; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor.
Topics: Animals; Bryostatins; Cell Line; Fibroblasts; Lactones; Lamins; Macrolides; Mitogens; Nuclear Envelope; Nuclear Proteins; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Serine; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Alteration of DNA topoisomerase II activity during infection of H9 cells by human immunodeficiency virus type 1 in vitro: a target for potential therapeutic agents.
Topics: Animals; Bryostatins; Cell Line; DNA Topoisomerases, Type I; Electrophoresis, Polyacrylamide Gel; HIV-1; In Vitro Techniques; Lactones; Lysophosphatidylcholines; Macrolides; Phosphorylation; Protein Kinase C; Rats; Rats, Inbred Strains; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
Direct and cytokine-mediated activation of protein kinase C induces human immunodeficiency virus expression in chronically infected promonocytic cells.
Topics: Biological Factors; Bryostatins; Cell Line; Cell Nucleus; Cytokines; Diglycerides; Enzyme Activation; Guanosine Triphosphate; HIV; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Mitogens; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Viral Proteins; Virus Replication | 1990 |
Activation of T-cells by bryostatins: induction of the IL-2 receptor gene transcription and down-modulation of surface receptors.
Topics: Antigens, Surface; Antineoplastic Agents; Bryostatins; CD3 Complex; CD4 Antigens; Down-Regulation; Gene Expression; Humans; Lactones; Lymphocyte Activation; Macrolides; Protein Kinase C; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Stimulation, Chemical; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
Control of actin conformation in AML myeloblasts: the effects of bryostatin and TPA.
Topics: Actins; Adult; Aged; Antineoplastic Agents; Bone Marrow; Bryostatins; Female; Flow Cytometry; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Male; Microscopy, Electron, Scanning; Middle Aged; Protein Conformation; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Phorbol esters activate proteoglycan metabolism in human colon cancer cells en route to terminal differentiation.
Topics: Bryostatins; Cell Differentiation; Cell Division; Colonic Neoplasms; Cycloheximide; Diglycerides; DNA Replication; Enzyme Activation; Heparitin Sulfate; Humans; Isoenzymes; Lactones; Macrolides; Membrane Proteins; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells.
Topics: Antineoplastic Agents; Bryostatins; DNA, Neoplasm; Down-Regulation; Enzyme Induction; Humans; Lactones; Macrolides; Neuroblastoma; Norepinephrine; Oncogenes; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Muscarinic; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Overexpression of protein kinase C beta 1 is not sufficient to induce factor independence in the interleukin-3-dependent myeloid cell line FDC-P1.
Topics: Bryostatins; Cell Line; Growth Substances; Hematopoietic System; Humans; Interleukin-2; Interleukin-3; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Arachidonic Acids; Bryostatins; Calcium; Cell Line; Cells, Cultured; Dinoprostone; DNA Replication; Enzyme Activation; Epidermis; Female; Keratins; Lactones; Macrolides; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Prostaglandins E; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transglutaminases | 1988 |
Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: relation to the multistep process of differentiation in human epidermal keratinocytes.
Topics: Bryostatins; Cell Differentiation; Cell Line, Transformed; Cholesterol Esters; Diglycerides; Epidermal Cells; Humans; Keratins; Lactones; Macrolides; Tetradecanoylphorbol Acetate; Tretinoin | 1989 |
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.
Topics: Aged; Antineoplastic Agents; B-Lymphocytes; Biomarkers, Tumor; Bryostatins; Calcimycin; Cell Adhesion; Cell Aggregation; Cell Differentiation; DNA, Neoplasm; Female; Humans; Immunoglobulins; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; Middle Aged; Receptors, Antigen, B-Cell; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
The effects of protein kinase-C agonists on parathyroid hormone release and intracellular free Ca2+ in bovine parathyroid cells.
Topics: Animals; Bryostatins; Calcium; Cattle; Diglycerides; Glycerides; In Vitro Techniques; Intracellular Fluid; Kinetics; Lactones; Macrolides; Parathyroid Glands; Parathyroid Hormone; Phosphotransferases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Effects of bryostatins and retinoic acid on phorbol ester- and diacylglycerol-induced squamous differentiation in human tracheobronchial epithelial cells.
Topics: Antineoplastic Agents; Bronchi; Bryostatins; Cell Differentiation; Cells, Cultured; Diglycerides; Epithelial Cells; Epithelium; Glycerides; Humans; Kinetics; Lactones; Macrolides; Organ Culture Techniques; Sulfates; Tetradecanoylphorbol Acetate; Trachea; Transglutaminases; Tretinoin | 1989 |
Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells.
Topics: Antineoplastic Agents; Bryostatins; Cell Line; Cytosol; Humans; Kinetics; Lactones; Lung Neoplasms; Macrolides; Membranes; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Bryostatins; Cells, Cultured; Cycloheximide; Dactinomycin; Enzyme Activation; Epidermal Growth Factor; Epidermis; Lactones; Macrolides; Mice; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transglutaminases | 1987 |
Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells.
Topics: Animals; Bryostatins; Cell Division; Diterpenes; DNA Replication; Enzyme Activation; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor.
Topics: Binding, Competitive; Blood Proteins; Bryostatins; Caenorhabditis elegans Proteins; Carrier Proteins; Cytoplasmic Granules; Humans; In Vitro Techniques; Lactones; Macrolides; Neutrophils; Phosphorylation; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Bryostatins mimic the effects of phorbol esters in intact human platelets.
Topics: Blood Platelets; Bryostatins; Enzyme Activation; Humans; Lactones; Macrolides; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Platelet Aggregation; Protein Kinase C; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
Comparative effects of polymyxin B, phorbol ester and bryostatin on protein phosphorylation, protein kinase C translocation, phospholipid metabolism and differentiation of HL60 cells.
Topics: Bryostatins; Cell Adhesion; Cell Differentiation; Cell Line; Dinoprostone; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phorbol Esters; Phosphatidylcholines; Phospholipids; Phosphorylation; Polymyxin B; Polymyxins; Prostaglandins E; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1987 |
Effect of phorbol and bryostatin I on chondrogenic expression of chick limb bud, in vitro.
Topics: Animals; Bryostatins; Cartilage; Cell Differentiation; Cells, Cultured; Chick Embryo; Chondroitin Sulfates; Enzyme Activation; Extremities; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
Co-induction of lymphokine synthesis by the antineoplastic bryostatins.
Topics: Antineoplastic Agents; Bryostatins; Calcimycin; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-2; Kinetics; Lactones; Lymphocytes; Lymphokines; Macrolides; Mitogens; Tetradecanoylphorbol Acetate | 1987 |
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bryostatins; Cell Line; Dogs; Lactones; Macrolides; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester stimulation of sphingomyelin synthesis in human leukemic HL60 cells.
Topics: Bryostatins; Cell Line; Choline; Diterpenes; Enzyme Activation; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phosphatidylcholines; Phosphorylation; Protein Kinase C; Sphingomyelins; Terpenes; Tetradecanoylphorbol Acetate | 1988 |
Differential modulation of protein kinase C by bryostatin 1 and phorbol ester.
Topics: Animals; Brain; Brain Chemistry; Bryostatins; Calcium; Enzyme Inhibitors; Lactones; Macrolides; Mice; Phosphatidylserines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Activation of human T lymphocytes by bryostatin.
Topics: Adjuvants, Immunologic; Bryostatins; Humans; Interleukin-2; Lactones; Lymphocyte Activation; Macrolides; Protein Kinase C; Receptors, Interleukin-2; Receptors, Transferrin; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1988 |
Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60).
Topics: Bryostatins; Cell Compartmentation; Cell Membrane; Cytoplasm; Gene Expression Regulation; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Transferrin; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1987 |
Bryostatin 1 antagonizes the terminal differentiating action of 12-O-tetradecanoylphorbol-13-acetate in a human colon cancer cell.
Topics: Bryostatins; Cell Differentiation; Cell Division; Cell Line; Colonic Neoplasms; DNA Replication; Humans; Lactones; Macrolides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Three activators of protein kinase C, bryostatins, dioleins, and phorbol esters, show differing specificities of action on GH4 pituitary cells.
Topics: Animals; Binding Sites; Binding, Competitive; Bryostatins; Cell Line; Diglycerides; Enzyme Activation; Eukaryota; Glycerides; Kinetics; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Phorbol Esters; Pituitary Neoplasms; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Topics: Bryostatins; Cell Differentiation; Cell Line; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phosphorylation; Protein Kinase C; Proteins; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles | 1987 |
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin.
Topics: Animals; Antineoplastic Agents; Bryostatins; Enzyme Activation; Female; Hyperplasia; Lactones; Macrolides; Mice; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters.
Topics: Animals; Bryostatins; Caenorhabditis elegans Proteins; Carcinogens; Carrier Proteins; Cells, Cultured; Insulin; Lactones; Macrolides; Mice; Mitogens; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thymidine | 1985 |
Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells.
Topics: Adolescent; Adult; Alprostadil; Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Basophils; Bryostatins; Calcimycin; Colforsin; Complement C5a; Histamine Release; Humans; Immunoglobulin E; Indomethacin; Lactones; Leukotriene C4; Lung; Macrolides; Mast Cells; Middle Aged; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Prostaglandin D2; Skin; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta.
Topics: Amino Acid Sequence; Animals; Bryostatins; Enzyme Activation; Isoenzymes; Lactones; Macrolides; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Spleen; Substrate Specificity; Swine; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
The antineoplastic bryostatins affect human basophils and mast cells differently.
Topics: Antibodies, Anti-Idiotypic; Basophils; Bryostatins; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine Release; Interleukin-3; Interleukin-5; Lactones; Leukotriene C4; Lung; Macrolides; Mast Cells; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate | 1995 |
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
Topics: Apoptosis; Breast Neoplasms; Bryostatins; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dose-Response Relationship, Drug; Female; GADD45 Proteins; Genes, p53; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lactones; Macrolides; Phosphorylation; Protein Kinase C; Proteins; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein kinase C chimeras: catalytic domains of alpha and beta II protein kinase C contain determinants for isotype-specific function.
Topics: Animals; Antineoplastic Agents; Baculoviridae; Base Sequence; Binding Sites; Bryostatins; Cell Division; Cell Line; DNA Primers; Humans; Isoenzymes; Lactones; Lamin Type B; Lamins; Leukemia, Erythroblastic, Acute; Macrolides; Mitogens; Molecular Sequence Data; Nuclear Proteins; Phosphorylation; Polymerase Chain Reaction; Protein Kinase C; Recombinant Fusion Proteins; Spodoptera; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
Loss of protein kinase C delta from human HaCaT keratinocytes upon ras transfection is mediated by TGF alpha.
Topics: Bryostatins; Cell Line, Transformed; Culture Media, Conditioned; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Repression; Gene Expression Regulation, Enzymologic; Genes, ras; Humans; Isoenzymes; Keratinocytes; Lactones; Macrolides; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Inhibition of leukemic cell growth by the protein kinase C activator bryostatin 1 correlates with the dephosphorylation of cyclin-dependent kinase 2.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Western; Bryostatins; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Humans; Lactones; Leukemia, Myeloid; Macrolides; Molecular Sequence Data; Phosphorylation; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphiregulin; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Culture Media, Conditioned; Cycloheximide; Dose-Response Relationship, Drug; EGF Family of Proteins; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Isoquinolines; Lactones; Macrolides; Piperazines; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells.
Topics: Animals; Blotting, Western; Bryostatins; Colony-Forming Units Assay; Drug Synergism; Enzyme Activation; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Interleukin-6; Lactones; Macrolides; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Protein Kinase C; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C delta accepts GTP for autophosphorylation.
Topics: Adenosine Triphosphate; Animals; Bryostatins; Electrophoresis, Polyacrylamide Gel; Guanosine Triphosphate; Isoenzymes; Kinetics; Lactones; Macrolides; Mitogens; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein Kinase C; Spleen; Substrate Specificity; Swine; Tetradecanoylphorbol Acetate | 1995 |
Mechanism of transferrin receptor down-regulation in K562 cells in response to protein kinase C activation.
Topics: Bryostatins; Cell Compartmentation; Down-Regulation; Endocytosis; Enzyme Activation; Humans; Lactones; Macrolides; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Transferrin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Modulation of gene expression in the acute promyelocytic leukemia cell line NB4.
Topics: Antigens, CD; Bryostatins; CD11 Antigens; Cell Differentiation; Cell Division; Cholecalciferol; Down-Regulation; Gene Expression Regulation, Leukemic; Genes, myc; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Peroxidase; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Establishment of a murine leukaemia cell line resistant to the growth-inhibitory effect of bryostatin 1.
Topics: Animals; Antineoplastic Agents; Bryostatins; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Drug Resistance; Enzyme Activation; Isoenzymes; Lactones; Leukemia P388; Macrolides; Mice; Protein Kinase C; Receptors, Drug; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Role of protein kinase C in ras-mediated fos-expression.
Topics: Animals; Bryostatins; Cell Compartmentation; Cell Line; Epithelial Cells; Gene Expression Regulation; Isoenzymes; Lactones; Macrolides; Mammary Glands, Animal; Mice; Protein Kinase C; Proto-Oncogene Proteins c-fos; ras Proteins; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection | 1994 |
Different biological effects of the two protein kinase C activators bryostatin-1 and TPA on human carcinoma cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Bryostatins; Cell Division; Cell Survival; DNA; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lactones; Macrolides; Melanoma; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sigmoid Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1994 |
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Biological Transport; Bryostatins; Cell Differentiation; Cells, Cultured; Down-Regulation; Isoenzymes; Keratinocytes; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Synthesis Inhibitors; Tetradecanoylphorbol Acetate | 1994 |
Partial purification of a type eta protein kinase C from murine brain: separation from other protein kinase C isoenzymes and characterization.
Topics: Alkaloids; Amino Acid Sequence; Animals; Baculoviridae; Brain; Bryostatins; Cell Line; Chromatography; Cytosol; Enzyme Activation; Gene Transfer Techniques; Immunosorbent Techniques; Isoenzymes; Lactones; Macrolides; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinase C; Recombinant Proteins; Spodoptera; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Translocation and downregulation of protein kinase C isoenzymes-alpha and -epsilon by phorbol ester and bryostatin-1 in human keratinocytes and fibroblasts.
Topics: Base Sequence; Biological Transport; Bryostatins; Cells, Cultured; Enzyme Activation; Fibroblasts; Humans; Isoenzymes; Keratinocytes; Lactones; Macrolides; Molecular Probes; Molecular Sequence Data; Polymerase Chain Reaction; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Wilms' tumor gene, WT1, mRNA is down-regulated during induction of erythroid and megakaryocytic differentiation of K562 cells.
Topics: Antigens, Differentiation; Base Sequence; Blotting, Northern; Bryostatins; Cell Differentiation; Cell Division; Cell Line, Transformed; DNA Probes; Erythrocytes; Genes, Wilms Tumor; Humans; Lactones; Leukemia; Macrolides; Megakaryocytes; Molecular Sequence Data; RNA, Messenger; Tetradecanoylphorbol Acetate | 1994 |
Inhibition of PMA-induced human T cell proliferation by bryostatin is associated with enhanced degradation of conventional protein kinase C (cPKC): Ca2+ signals restore mitogenic activity without abrogating enhanced cPKC degradation.
Topics: Biological Transport; Bryostatins; Calcium; Cell Membrane; Cells, Cultured; Drug Synergism; Humans; Interleukin-2; Ionomycin; Lactones; Lymphocyte Activation; Macrolides; Mitogens; Protein Kinase C; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1994 |
Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Bryostatins; CD11 Antigens; Cell Adhesion Molecules; Cell Differentiation; Enzyme Activation; Female; Humans; Immunophenotyping; Lactones; Lectins; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; Middle Aged; Protein Kinase C; Sialic Acid Binding Ig-like Lectin 2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbol esters.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Base Sequence; Bryostatins; Cell Differentiation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Epithelium; Gene Expression Regulation, Enzymologic; Humans; Keratinocytes; Lactones; Luciferases; Macrolides; Molecular Sequence Data; Promoter Regions, Genetic; Rabbits; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Tetradecanoylphorbol Acetate; Trachea; Transcription, Genetic; Transfection; Transglutaminases; Tretinoin | 1993 |
The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Cell Division; Chromatography; Durapatite; Enzyme Activation; Humans; Isoenzymes; Lactones; Lung Neoplasms; Macrolides; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
The effect of bryostatin on protein kinase C-regulated functions in human T lymphocytes and epidermal keratinocytes.
Topics: Adjuvants, Immunologic; Amino Acid Sequence; Antineoplastic Agents; Bryostatins; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Keratinocytes; Lactones; Lymphocyte Activation; Macrolides; Mitogens; Molecular Sequence Data; Protein Kinase C; Skin; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1993 |
Induction of the c-ski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation.
Topics: Bryostatins; Cell Differentiation; Culture Media; Dose-Response Relationship, Drug; Humans; Lactones; Leukemia, Megakaryoblastic, Acute; Macrolides; Megakaryocytes; Membrane Glycoproteins; Mercaptopurine; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes.
Topics: Alkaloids; Amino Acid Sequence; Bryostatins; Calcium; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Enzyme Induction; Epidermal Cells; Etretinate; Humans; Keratinocytes; Lactones; Macrolides; Molecular Sequence Data; Protein Kinase C; Protein Synthesis Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Expression and modulation of annexin VIII in human leukemia-lymphoma cell lines.
Topics: Annexins; Blotting, Northern; Bryostatins; Cell Differentiation; Cholecalciferol; Dactinomycin; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Lactones; Leukemia; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Lymphoma; Macrolides; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Bryostatin 1 induces productive Epstein-Barr virus replication in latently infected cells: implications for use in immunocompromised patients.
Topics: Antineoplastic Agents; B-Lymphocytes; Bryostatins; Cell Transformation, Viral; Herpesvirus 4, Human; Humans; Immunocompromised Host; Lactones; Macrolides; Tetradecanoylphorbol Acetate; Virus Latency; Virus Replication | 1993 |
Toxicity of phorbol esters for human epithelial cells expressing a mutant ras oncogene.
Topics: Antineoplastic Agents; Bryostatins; Cell Division; Cell Line; DNA; Epithelial Cells; Epithelium; Gene Expression Regulation; Genes, ras; Humans; Lactones; Macrolides; Models, Biological; Mutation; Phorbol 12,13-Dibutyrate; Phorbol Esters; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thyroid Gland; Zinc | 1993 |
A bryostatin-sensitive protein kinase C required for nerve growth factor activity.
Topics: Animals; Bryostatins; Cell Differentiation; Enzyme Activation; Genes, fos; Genes, jun; Kinetics; Lactones; Macrolides; Nerve Growth Factors; Neurites; Neurons; PC12 Cells; Protein Kinase C; RNA, Messenger; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Bryostatins; Enzyme Activation; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Enzymologic; Isoenzymes; Kinetics; Lactones; Macrolides; Mice; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Bryostatin 1-induced modulation of the acute lymphoblastic leukemia cell line Reh.
Topics: Acid Phosphatase; Antigens, CD; Antineoplastic Agents; B-Lymphocytes; Bryostatins; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Differentiation; Cell Division; Humans; Lactones; Macrolides; Microscopy, Electron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Different effects of the two protein kinase C activators bryostatin-1 and TPA on growth and differentiation of human monocytic leukemia cell lines.
Topics: Adult; Aged; Antineoplastic Agents; Bryostatins; Cell Differentiation; Cell Division; Enzyme Activation; Female; Humans; Lactones; Leukemia, Monocytic, Acute; Macrolides; Male; Protein Kinase C; Proto-Oncogene Proteins c-myc; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Protein kinase C activation without membrane contact in platelets stimulated by bryostatin.
Topics: Biological Transport; Blood Platelets; Bryostatins; Calcium; Cell Membrane; Cell-Free System; Enzyme Activation; Humans; In Vitro Techniques; Isoenzymes; Lactones; Macrolides; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate | 1993 |
Protein kinase C-alpha but not protein kinase C-epsilon is differentially down-regulated by bryostatin 1 and tetradecanoyl phorbol 13-acetate in SH-SY5Y human neuroblastoma cells.
Topics: Biological Transport; Bryostatins; Cell Differentiation; Cytosol; Down-Regulation; Enzyme Activation; Humans; Isoenzymes; Lactones; Macrolides; Neuroblastoma; Phosphorylation; Protein Kinase C; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway.
Topics: Alkaloids; Bryostatins; Cell Differentiation; Cellular Senescence; Gene Expression; Genes, fos; Humans; Lactones; Macrolides; Neuroblastoma; Neurons; Phenotype; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Mas; Staurosporine; Subcellular Fractions; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Hierarchical analysis of the nerve growth factor-dependent and nerve growth factor-independent differentiation signaling pathways in PC12 cells with protein kinase inhibitors.
Topics: Alkaloids; Animals; Bryostatins; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indole Alkaloids; Lactones; Macrolides; Models, Biological; Neoplasm Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins p21(ras); Rats; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thioguanine | 1995 |
Nordihydroguaiaretic acid blocks IL-2-independent lymphocyte proliferation and enhances responses to PPD.
Topics: Adjuvants, Immunologic; Bryostatins; Cyclosporine; Humans; Interleukin-2; Interleukin-6; Lactones; Lipoxygenase Inhibitors; Lymphocyte Activation; Macrolides; Masoprocol; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tuberculin | 1996 |
Phorbol ester-stimulated phosphorylation of PU.1: association with leukemic cell growth inhibition.
Topics: Base Sequence; Bryostatins; Cell Differentiation; Cell Division; DNA, Neoplasm; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Humans; Indoles; Lactones; Lymphoma, Large B-Cell, Diffuse; Macrolides; Maleimides; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Proto-Oncogenes; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1 alpha,25-(OH)2D3 and 24R,25-(OH)2D3.
Topics: 24,25-Dihydroxyvitamin D 3; Animals; Bryostatins; Calcitriol; Calcium; Cartilage; Cell Membrane; Cells, Cultured; Egtazic Acid; Enzyme Inhibitors; Extracellular Matrix; Isoenzymes; Lactones; Liposomes; Macrolides; Peptides; Protease Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Differentiating agents do not induce a true hairy cell phenotype in B-CLL cells in vitro.
Topics: Acid Phosphatase; Antigens, CD; Antigens, Neoplasm; B-Lymphocytes; Biomarkers, Tumor; Bryostatins; Cell Differentiation; Enzyme Activation; Humans; Immunophenotyping; Isoenzymes; Lactones; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Neoplastic Stem Cells; Protein Kinase C; Tartrate-Resistant Acid Phosphatase; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1996 |
Dephosphorylation of activated protein kinase C contributes to downregulation by bryostatin.
Topics: Alkaline Phosphatase; Antineoplastic Agents; Biological Transport; Bryostatins; Cell Line; Enzyme Activation; Isoenzymes; Kidney; Lactones; Macrolides; Molecular Weight; Phosphorylation; Precipitin Tests; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine.
Topics: Basophils; Binding, Competitive; Bryostatins; Chemokine CCL2; Chemokine CCL5; Complement C5a; Cyclosporine; Histamine Release; Humans; Interleukin-1; Interleukin-8; Kinetics; Lactones; Leukotriene C4; Macrolides; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Platelet Activating Factor; Protein Binding; Tetradecanoylphorbol Acetate | 1996 |
Phorbol ester augments butyrate-induced apoptosis of colon cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Bryostatins; Butyrates; Butyric Acid; Cell Division; Colonic Neoplasms; Drug Interactions; Enzyme Activation; Humans; Kinetics; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Substance P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Antibodies, Anti-Idiotypic; Bryostatins; Cyclic AMP; Enzyme Activation; Genistein; GTP-Binding Proteins; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Isoflavones; Lactones; Macrolides; Mast Cells; Pertussis Toxin; Protease Inhibitors; Protein Kinase C; Skin; Skin Physiological Phenomena; Substance P; Sulfones; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1996 |
Early response gene signalling in bryostatin-stimulated primary B chronic lymphocytic leukaemia cells in vitro.
Topics: Bryostatins; DNA Replication; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genes, myc; Humans; Immunoglobulin M; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Activation; Macrolides; Oligonucleotides, Antisense; RNA; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1996 |
Activation of conventional mammalian protein kinase C isoforms expressed in budding yeast modulates the cell doubling time--a potential in vivo screen for protein kinase C activators.
Topics: Animals; Bryostatins; Cattle; Cell Division; Diterpenes; Enzyme Activation; Indoles; Isoenzymes; Lactams; Lactones; Macrolides; Phorbol Esters; Plasmids; Protein Kinase C; Saccharomyces cerevisiae; Sequence Deletion; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Transcriptional regulation of insulin receptor substrate 1 by protein kinase C.
Topics: Animals; Antineoplastic Agents; Bryostatins; Down-Regulation; Enzyme Activation; Female; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Isoenzymes; Lactones; Macrolides; Mice; Phosphoproteins; Protein Kinase C; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts.
Topics: Acetylcysteine; Bryostatins; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Fibroblasts; Glycoproteins; Humans; Isoenzymes; Lactones; Macrolides; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Ubiquitins | 1997 |
Effects of TPA, bryostatin 1, and retinoic acid on PO-B, AP-1, and AP-2 DNA binding during HL-60 differentiation.
Topics: Antineoplastic Agents; Bryostatins; Cell Differentiation; Dimethyl Sulfoxide; DNA; DNA-Binding Proteins; Granulocytes; HL-60 Cells; Humans; Lactones; Macrolides; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factor AP-2; Transcription Factors; Tretinoin | 1997 |
Tumor promotion by depleting cells of protein kinase C delta.
Topics: Animals; Antineoplastic Agents; Bryostatins; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Down-Regulation; Fibroblasts; Isoenzymes; Lactones; Macrolides; Phenotype; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Proto-Oncogene Proteins pp60(c-src); Rats; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Posttranslational regulation of Lck and a p36-38 protein by activators of protein kinase C: differential effects of the tumor promoter, PMA, and the non-tumor-promoter, bryostatin.
Topics: Adjuvants, Immunologic; Bryostatins; Carcinogens; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Lactones; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Macrolides; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Proteins; src-Family Kinases; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Bryostatin 1 induces biphasic activation of protein kinase D in intact cells.
Topics: 3T3 Cells; Animals; Bryostatins; Dose-Response Relationship, Drug; Enzyme Activation; Kinetics; Lactones; Macrolides; Mice; Mitogens; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate | 1997 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on inhibition of expression of keratin 1 mRNA in mouse keratinocytes mimicked by 12(S)-hydroxyeicosatetraenoic acid.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Blotting, Western; Bryostatins; Carcinogens; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Keratinocytes; Keratins; Lactones; Macrolides; Mice; Mice, Inbred SENCAR; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA, Messenger; Tetradecanoylphorbol Acetate | 1997 |
Isoform specificity of activators and inhibitors of protein kinase C gamma and delta.
Topics: Acetophenones; Alkaloids; Benzophenanthridines; Benzopyrans; Bryostatins; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Lactones; Macrolides; Maleimides; Naphthalenes; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Schizosaccharomyces; Sphingosine; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1997 |
Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Cell Cycle; Cytarabine; Diterpenes; DNA Fragmentation; Drug Synergism; Enzyme Activation; HL-60 Cells; Humans; Kinetics; Lactones; Macrolides; Oligonucleotides, Antisense; Phorbol 12,13-Dibutyrate; Protein Kinase C; Proto-Oncogene Proteins c-myc; Terpenes; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Binding Sites; Bryostatins; Catalysis; Down-Regulation; Enzyme Activation; Isoenzymes; Lactones; Macrolides; Mice; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 1997 |
Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro.
Topics: Animals; Bryostatins; Cell Division; Drug Synergism; Enzyme Activation; Growth Inhibitors; Lactones; Leukemia P388; Macrolides; Mice; Protein Kinase C; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1998 |
Involvement of phospholipase D and protein kinase C in phorbol ester and fatty acid stimulated turnover of phosphatidylcholine and phosphatidylethanolamine in neural cells.
Topics: Animals; Antineoplastic Agents; Bryostatins; Down-Regulation; Enzyme Activation; Fatty Acids; Humans; Lactones; Macrolides; Mice; Neuroglia; Neurons; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Effects of bryostatin 1 and calcium ionophore (A23187) on apoptosis and differentiation in human myeloid leukemia cells (HL-60) following 1-beta-D-arabinofuranosylcytosine exposure.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Bryostatins; Calcimycin; Calcium; Cell Differentiation; Cytarabine; DNA Fragmentation; HL-60 Cells; Humans; Lactones; Macrolides; Tetradecanoylphorbol Acetate | 1998 |
The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C.
Topics: Blood; Bryostatins; Calcium; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Culture Media; Cytoskeletal Proteins; Desmoglein 1; Desmoglein 2; Desmogleins; Desmoplakins; Desmosomes; Enzyme Activation; Gene Expression Regulation; Humans; Infant, Newborn; Keratinocytes; Kinetics; Lactones; Macrolides; Male; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Selective activation by bryostatin-1 demonstrates unique roles for PKC epsilon in neurite extension and tau phosphorylation.
Topics: Bryostatins; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Lactones; Macrolides; Neurites; Neurons; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Staurosporine; tau Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells.
Topics: Antineoplastic Agents; Arachidonic Acid; Breast Neoplasms; Bryostatins; Cell Division; Dinoprostone; Enzyme Activation; Female; Humans; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937).
Topics: Antineoplastic Agents; Blotting, Western; Bryostatins; Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Regulation; Humans; Lactones; Lymphoma, Large B-Cell, Diffuse; Macrolides; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1998 |
Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: role of protein kinase C.
Topics: Antineoplastic Agents; Biological Transport; Bryostatins; Carcinogens; Carrier Proteins; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Gene Expression; Humans; Intestinal Mucosa; Lactones; Macrolides; Potassium; Protein Kinase C; RNA, Messenger; Sodium; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate | 1998 |
Inhibition of membrane lipid-independent protein kinase Calpha activity by phorbol esters, diacylglycerols, and bryostatin-1.
Topics: Allosteric Regulation; Animals; Bryostatins; Diglycerides; Drug Interactions; Enzyme Induction; Fluorescent Dyes; Isoenzymes; Lactones; Macrolides; Membrane Lipids; Phorbol Esters; Protamines; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Rats; Recombinant Proteins; Solubility; Tetradecanoylphorbol Acetate | 1998 |
Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells.
Topics: Apoptosis; Bryostatins; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; G1 Phase; Humans; Lactones; Leukemia, Myeloid; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; U937 Cells | 1998 |
Protein kinase C delta (PKCdelta) inhibits the expression of glutamine synthetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation.
Topics: Bryostatins; Catalytic Domain; Cells, Cultured; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Humans; Isoenzymes; Lactones; Macrolides; Mutagenesis, Site-Directed; Neuroglia; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1998 |
Bryostatin-1 and 1alpha,25-dihydroxyvitamin D3 synergistically stimulate the differentiation of NB4 acute promyelocytic leukemia cells.
Topics: Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Bryostatins; Calcitriol; Cell Differentiation; Cell Division; Drug Synergism; Enzyme Induction; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Regulation of motility and protease expression in PKC-mediated induction of MCF-7 breast cancer cell invasiveness.
Topics: Breast Neoplasms; Bryostatins; Cathepsin D; Cell Movement; Endopeptidases; Enzyme Activation; Humans; Lactones; Macrolides; Metalloendopeptidases; Neoplasm Invasiveness; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1999 |
Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Bryostatins; Cell Cycle Proteins; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytarabine; Deoxycytidine; Drug Interactions; Enzyme Activation; Gemcitabine; Humans; Lactones; Leukemia; Macrolides; Microtubule-Associated Proteins; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins; U937 Cells | 1999 |
p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Bryostatins; Carrier Proteins; Cell Line; COS Cells; Enzyme Activators; Enzyme Inhibitors; Humans; Lactones; Macrolides; Phosphorylation; Protein Isoforms; Protein Kinase C; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1999 |
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein.
Topics: Animals; Bryostatins; CHO Cells; Cricetinae; Diglycerides; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Isoenzymes; Lactones; Luminescent Proteins; Macrolides; Protein Kinase C; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Overexpression of novel protein kinase C delta in BL6 murine melanoma cells inhibits the proliferative capacity in vitro but enhances the metastatic potential in vivo.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bryostatins; Cell Cycle; Cell Division; Cyclic AMP; Isoenzymes; Lactones; Macrolides; Melanins; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Proteins; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2000 |
Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha.
Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Bryostatins; Carcinogens; Cell Division; Down-Regulation; Enzyme Activation; Humans; Isoenzymes; Lactones; Macrolides; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-raf; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells.
Topics: Active Transport, Cell Nucleus; Binding Sites; Bryostatins; Cell Differentiation; Cell Nucleus; Cytosol; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Genes, myc; Genes, Reporter; HL-60 Cells; Humans; Indoles; Introns; Lactones; Macrolides; Maleimides; Nuclear Proteins; Protein Binding; Protein Kinase C; Proto-Oncogene Proteins c-myc; Regulatory Factor X Transcription Factors; Regulatory Factor X1; Response Elements; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection | 2000 |
Biphasic effect of protein kinase C activators on spontaneous and glucocorticoid-induced apoptosis in primary mouse thymocytes.
Topics: Animals; Apoptosis; Bryostatins; Carbazoles; Cells, Cultured; DNA Fragmentation; Down-Regulation; Enzyme Activation; Female; Fluocinolone Acetonide; Glucocorticoids; Immunoblotting; Indoles; Isoenzymes; Lactones; Macrolides; Mice; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymus Gland | 2000 |
The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha.
Topics: Animals; Biological Transport; Bryostatins; Carbazoles; Cell Line; Cell Membrane Permeability; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Indoles; Isoenzymes; Kinetics; Lactones; Leupeptins; Macrolides; Mannitol; Membrane Potentials; Multienzyme Complexes; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; Tight Junctions | 2000 |
Protein kinase C activation modulates pro- and anti-apoptotic signaling pathways.
Topics: Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Bryostatins; Calcitriol; Caspases; Cell Cycle; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Indoles; Isoenzymes; Lactones; Macrolides; Maleimides; Membrane Glycoproteins; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Tumor Necrosis Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
12-O-tetradecanoylphorbol-13-acetate induces apoptosis in renal epithelial cells through a growth signal conflict which is prevented by activated ras.
Topics: Animals; Apoptosis; Blotting, Western; Bryostatins; Caspase 3; Caspases; Cell Cycle Proteins; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Activation; Epithelial Cells; Genes, ras; Kidney; Lactones; Macrolides; Microtubule-Associated Proteins; Okadaic Acid; Oncogene Protein p21(ras); Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Retinoblastoma Protein; Signal Transduction; Swine; Tetradecanoylphorbol Acetate; Tumor Suppressor Proteins | 2001 |
Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms.
Topics: Biological Transport; Bryostatins; Carbachol; Cells, Cultured; Cholinergic Agonists; Enzyme Inhibitors; Humans; Intestinal Mucosa; Isoenzymes; Lactones; Macrolides; Permeability; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Time Factors; Tissue Distribution | 2001 |
Different levels of TGFbeta, IL-10, IFNgamma and gelatinase A occur in experimental white and black metastases induced by bryostatin 1 or by phorbol ester-treated BL6T murine melanoma cells.
Topics: Animals; Antineoplastic Agents; Bryostatins; Interferon-gamma; Interleukin-10; L-Lactate Dehydrogenase; Lactones; Lung Neoplasms; Macrolides; Matrix Metalloproteinase 2; Melanoma; Mice; Mice, Inbred C57BL; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 2000 |
Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia.
Topics: Biological Transport; Bryostatins; Carcinogens; Cell Hypoxia; Cell Line; Chlorides; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Intestinal Mucosa; Ischemia; Isoenzymes; Lactones; Macrolides; Maleimides; Mitogens; Protein Kinase C; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate | 2001 |
Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblasts.
Topics: 3T3 Cells; Acetophenones; Active Transport, Cell Nucleus; Animals; Benzopyrans; Bryostatins; Cell Cycle; Cell Division; Chemotaxis; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Fixatives; Glutaral; Humans; Isoenzymes; Lactones; Macrolides; Mice; Mitogens; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Bryostatins; Carbazoles; Carcinogens; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Separation; Cytosol; Enzyme Inhibitors; fas Receptor; Fas-Associated Death Domain Protein; Flow Cytometry; Humans; Indoles; Jurkat Cells; Lactones; Macrolides; Mitogens; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Transport; Signal Transduction; Subcellular Fractions; Tetradecanoylphorbol Acetate | 2001 |
Bryostatin-1 specifically inhibits in vitro IgE synthesis.
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Bryostatins; Cell Division; HMGB1 Protein; Humans; Immunoglobulin Class Switching; Immunoglobulin E; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Phosphorylation; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2001 |
Effect of protein kinase C on endoplasmic reticulum cholesterol.
Topics: Acetophenones; Benzopyrans; Bryostatins; Calcium; Cell Membrane; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Fibroblasts; Humans; Lactones; Macrolides; Mitogens; Naphthalenes; Protein Isoforms; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtypes.
Topics: Amino Acid Transport System X-AG; Animals; Bryostatins; Carbazoles; Carcinogens; Carrier Proteins; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Female; Glutamate Plasma Membrane Transport Proteins; Indoles; Lactones; Macrolides; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Symporters; Tetradecanoylphorbol Acetate | 2002 |
Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase.
Topics: Aldehyde Reductase; Animals; Bryostatins; Cells, Cultured; COS Cells; HL-60 Cells; Humans; Intracellular Membranes; Lactones; Macrolides; Mitochondria; Muscle, Smooth, Vascular; Phosphorus Radioisotopes; Phosphorylation; Protein Kinase C; Protein Transport; Rats; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate | 2003 |
Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Bryostatins; Calpain; Cell Line, Tumor; Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Intestinal Mucosa; Lactones; Macrolides; Marine Toxins; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Okadaic Acid; Oxazoles; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Rats; Signal Transduction; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors; Ubiquitin | 2004 |
B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta.
Topics: Acetamides; Acetophenones; Animals; B-Lymphocytes; Benzopyrans; Binding Sites; Blotting, Western; Bryostatins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Division; Cross-Linking Reagents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mitogens; Phosphorylation; Promoter Regions, Genetic; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Structure, Tertiary; Pyrans; Receptors, Antigen, B-Cell; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Spiro Compounds; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Synthetic bryostatin analogues activate the RasGRP1 signaling pathway.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bryostatins; Cell Aggregation; Cell Membrane; Cells, Cultured; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Guanine Nucleotide Exchange Factors; Humans; Immunologic Factors; Lactones; Lectins, C-Type; Macrolides; Mice; Mutation; Phosphorylation; Protein Kinase C; Protein Transport; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland; Transfection | 2004 |
Enhancement of cisplatin sensitivity of cisplatin-resistant human cervical carcinoma cells by bryostatin 1.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bryostatins; Caspase 3; Caspases; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Female; HeLa Cells; Humans; Indoles; Lactams; Macrolides; Phorbol 12,13-Dibutyrate; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transfection; Uterine Cervical Neoplasms | 2005 |
Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.
Topics: Animals; Antineoplastic Agents; Axotomy; Brain-Derived Neurotrophic Factor; Bryostatins; Butadienes; Cell Survival; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Macrolides; Morpholines; Nerve Growth Factors; Nerve Regeneration; Neurons; Neuroprotective Agents; Neurotrophin 3; Nitriles; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar; Spiral Ganglion; Tetradecanoylphorbol Acetate | 2005 |
Overexpression of PKCepsilon sensitizes LNCaP human prostate cancer cells to induction of apoptosis by bryostatin 1.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dihydrotestosterone; Dose-Response Relationship, Drug; Humans; Immunoblotting; Macrolides; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C-epsilon; Retinoblastoma Protein; Tetradecanoylphorbol Acetate; Transfection | 2006 |
Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cell Membrane; Diglycerides; Down-Regulation; Epidermal Cells; Epidermis; Guanine Nucleotide Exchange Factors; Keratinocytes; Macrolides; Mice; Nuclear Envelope; Plasma; Protein Transport; Tetradecanoylphorbol Acetate | 2006 |
Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta.
Topics: Bryostatins; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Macrolides; Protein Kinase C-delta; Tetradecanoylphorbol Acetate | 2006 |
Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.
Topics: Acetophenones; Benzopyrans; Bronchi; Bryostatins; Cell Line; Enzyme Activation; Epithelial Cells; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Mucins; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate | 2007 |
Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.
Topics: Biomimetic Materials; Bryostatins; Pyrans; Tetradecanoylphorbol Acetate | 2008 |
Endothelial PKC delta activation attenuates neutrophil transendothelial migration.
Topics: Antineoplastic Agents; Bryostatins; Carbazoles; Carcinogens; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Kinase 1; Humans; Leukotriene B4; Neutrophils; Paxillin; Protein Kinase C-delta; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vinculin | 2008 |
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
Topics: Bryostatins; Cyclization; Molecular Structure; Protein Kinase C; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2009 |
Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) delta translocation and preventing PKCdelta-mediated release of tumor necrosis factor-alpha.
Topics: Antineoplastic Agents; Apoptosis; Bryostatins; Humans; Isoenzymes; Lactones; Male; Phorbol Esters; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C-delta; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2010 |
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Topics: Apoptosis; Bryostatins; Cell Division; Cell Line, Tumor; Down-Regulation; Humans; Male; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2011 |
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.
Topics: Anti-HIV Agents; Azepines; Bryostatins; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Depsipeptides; Disulfiram; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Hydroxamic Acids; Indoles; Ionomycin; Lymphocyte Activation; Nuclear Proteins; Panobinostat; Tetradecanoylphorbol Acetate; Transcription Factors; Triazoles; Virus Latency; Vorinostat | 2014 |
Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.
Topics: Animals; Antineoplastic Agents; Bryostatins; Bryozoa; Cell Line, Tumor; Cell Proliferation; Humans; Hydrogenation; Leukemia; Models, Molecular; Protein Kinase C-alpha; Tetradecanoylphorbol Acetate; U937 Cells | 2014 |
Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin.
Topics: Animals; Antineoplastic Agents; Bryostatins; Cyclooxygenase 2; Disease Models, Animal; Edema; Female; Mice; Ornithine Decarboxylase; Peroxidase; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2018 |