tetradecanoylphorbol acetate has been researched along with arachidonic acid in 766 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 228 (29.77) | 18.7374 |
| 1990's | 420 (54.83) | 18.2507 |
| 2000's | 93 (12.14) | 29.6817 |
| 2010's | 23 (3.00) | 24.3611 |
| 2020's | 2 (0.26) | 2.80 |
| Authors | Studies |
|---|---|
| Rivedal, E; Sanner, T | 1 |
| Conquer, JA; Cruz, TF; Kandel, RA | 1 |
| Alava, M; Bonvini, E; Hoffman, T; Puri, J; Taplits, M | 1 |
| Davis, BB; Jacob, AK; Reznikoff, CA; Thomas, DJ; Zenser, TV | 1 |
| Koizumi, H; Ohkawara, A; Sato, KC | 1 |
| Franson, RC; Lattanzio, KS; Rosenthal, MD | 1 |
| Akimaru, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Douglas, SD; Greer, W; Kilpatrick, L; Korchak, HM; Majumdar, S; McCawley, L; Nachiappan, V | 1 |
| Bertrand, W; Irwin, C; Mordhorst, M; Morrison, AR; Portilla, D | 1 |
| Bahler, C; Garcia, JG; Natarajan, V; Stasek, JE | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 1 |
| Sundler, R; Wijkander, J | 3 |
| Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Hayashi, J; Liu, PS; Sun, L; Wen, M | 1 |
| Robinson, PJ | 1 |
| Edwin, SS; Mitchell, MD | 1 |
| Agarwal, R; Katiyar, SK; Mukhtar, H; Wood, GS | 1 |
| Aizu, E; Kato, R; Yamamoto, S | 1 |
| Smith, DM; Waite, M | 1 |
| Honda, K; Imai, H; Miyake, A; Takebayashi, Y; Yamamoto, H | 1 |
| Kozawa, O; Miwa, M; Tokuda, H | 1 |
| Blanquet, PR; Patte, C | 1 |
| Brown, EJ; Lefkowith, JB; Lennartz, MR; Morrison, AR; Rogers, M | 1 |
| Batt, DG; Collins, RJ; Corbett, RL; Green, AM; Harris, RR; Wadman, EA; Wright, SW | 1 |
| Tatarintsev, AV; Varfolomeyev, SD; Vrzheshch, PV; Yershov, DE | 1 |
| Hoffman, T; Pierce, JH; Puri, J | 2 |
| Crichton, CA; Currie, S; Hallam, C; Jackson, CG; Smith, GL; Wakelam, MJ | 1 |
| Dominguez, J; Garcia, JG; Natarajan, V; Patterson, CE; Stasek, J | 1 |
| Schatz-Munding, M; Ullrich, V | 1 |
| Berglindh, T; Nygård, G | 2 |
| Deyrup-Olsen, I; Louie, H; Luchtel, DL; Martin, AW | 1 |
| Kremer, SG; Skorecki, KL; Sridhara, S; Zeng, W | 1 |
| Chakraborti, S; Michael, JR; Sanyal, T | 1 |
| Kanaho, Y; Nishida, A; Nozawa, Y | 1 |
| Knopf, JL; Lin, AY; Lin, LL | 1 |
| Levine, L | 7 |
| Cordier, J; Giaume, C; Glowinski, J; Marin, P; Premont, J | 1 |
| Denning, GM; Welsh, MJ | 1 |
| Gustafson, C; Lindahl, M; Tagesson, C | 1 |
| Edashige, K; Inoue, M; Matsuno, T; Sato, EF; Takahashi, R; Utsumi, K | 1 |
| Saeki, K; Utsumi, K; Yamamoto, M | 1 |
| Bainton, AL; Devalia, V; Faint, R; Linch, DC; Pilkington, GR; Pizzey, A; Roberts, PJ; Thomas, NS | 1 |
| Bensussan, A; Bihoreau, C; Corvaïa, N; Degos, L; Enjalbert, A; Heurtier, A; Kordon, C | 1 |
| Fabbro, D; Huwiler, A; Pfeilschifter, J | 1 |
| Elmore, M; Kellie, S; Murphy, CT; Westwick, J | 1 |
| Fürstenberger, G; Kast, R; Marks, F | 2 |
| Fujie, K; Handa, H; Sakamoto, W | 1 |
| Harris, T; Stewart, AG | 1 |
| Masuda, Y; Takanaka, K; Taniguchi, K | 2 |
| Beraud, M; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC | 1 |
| Bosia, A; Bussolino, F; Garbarino, G; Ghigo, D; Heller, R; Pescarmona, G; Schröder, H; Till, U | 1 |
| Cohan, VL; Gittlen, SW; Kagey-Sobotka, A; Lichtenstein, LM; MacGlashan, DW; Massey, WA; Warner, JA | 1 |
| Cantraine, F; Christophe, J; Dehaye, JP; Delporte, C; Poloczek, P; Winand, J | 1 |
| Basudev, H; Howell, SL; Jones, PM; Persaud, SJ | 1 |
| Davis, BB; Jacob, AK; Thomas, DJ; Zenser, TV | 1 |
| Breton, M; Colard, O | 1 |
| Hsu, SM; Mehta, K; Sanduja, R; Sanduja, SK; Wu, KK; Xu, XM | 1 |
| Fujie, K; Mino, M; Morita, I; Murota, S; Nishihira, J; Sakamoto, W | 1 |
| Barchowsky, A; Buckley, BJ; Dolor, RJ; Whorton, AR | 1 |
| Thams, P | 1 |
| Bellavite, P; Guzzo, P; Lauciello, C; Negri, M; Zatti, M | 1 |
| Astruc, ME; Crastes de Paulet, A; Lahoua, Z; Michel, F; Vial, H | 1 |
| Lonigro, AJ; Sprague, RS; Stephenson, AH | 1 |
| Apgar, JR | 1 |
| Marty, A; Tan, YP | 1 |
| Abrahamsen, TG; Bonvini, E; Brando, C; Hansen, M; Hoffman, T; Lee, YL; Lizzio, EF; Puri, J; Taplits, M; Tripathi, AK | 1 |
| Axelrod, J; Briley, EM; Felder, CC; Kanterman, RY; Mahan, LC; Monsma, FJ; Sibley, DR | 1 |
| Abidi, TF; Conney, AH; Ferraro, T; Huang, MT; Laskin, JD; Lysz, T | 1 |
| Cameron, GS; Fischer, SM; Lee, ML; Patrick, KE | 1 |
| Fürstenberger, G; Kaszkin, M; Kinzel, V | 1 |
| Banga, HS; Feinstein, MB; Halenda, SP | 1 |
| Bonventre, JV; Sellmayer, A; Uedelhoven, WM; Weber, PC | 1 |
| Duniec, ZM; Eling, TE; Nettesheim, P | 1 |
| Brash, AR; Hughes, MA | 1 |
| Abrahamsen, TG; Carter, CS; Hoffman, T; Jessop, JJ; Lee, YL; Lizzio, EF; Puri, J; Taplits, M; Tripathi, AK | 1 |
| Ackerman, SJ; Dvorak, AM; Picard, ST; Ryeom, SW; Weller, PF | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| Garcia, MC; Mueller, HW; Rosenthal, MD | 1 |
| Foreyt, WJ; Laegreid, WW; Leid, RW; Liggitt, HD; Silflow, RM; Taylor, SM | 1 |
| Decker, K; Gyufko, K; Tran-Thi, TA | 1 |
| Gilliam, EB; Rosenblatt, HM; Schulam, PG; Shearer, WT; Whelan, JP | 1 |
| Goppelt-Struebe, M; Hass, R; Rehfeldt, W | 1 |
| Fürstenberger, G; Hanke, B; Marks, F; Thastrup, O | 1 |
| Mattila, P; Renkonen, R | 1 |
| Abidi, TF; Conney, AH; Ferraro, T; Huang, MT; Laskin, JD; Lysz, T; Manchand, PS | 1 |
| Chen, HI; Chou, CL; Hsu, K; Wang, D | 1 |
| Cybulsky, AV | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Yokota, K | 1 |
| Golenbock, DT; Hampton, RY; Qureshi, N; Raetz, CR; Takayama, K | 1 |
| Branch, DW; Daynes, RA; Dudley, DJ; Lundin-Schiller, S; Mitchell, MD; Romero, RJ | 1 |
| Cockcroft, S; Nielson, CP; Stutchfield, J | 1 |
| Ganguly, NK; Khullar, M; Khurana, S; Panigrahi, D; Walia, BN | 1 |
| Bultmann, H; Glade, U; Häfker, T; Vicker, MG | 1 |
| Johnson, AL; Tilly, JL | 1 |
| DeWitt, DL; Goppelt-Struebe, M; Hass, R; Kaever, V; Koehler, L; Resch, K; Wessel, K | 1 |
| Conquer, J; Mahadevappa, VG | 1 |
| Kaever, V; Pfannkuche, HJ; Resch, K; Wessel, K | 1 |
| Beraud, M; Combis, JM; Forgue, MF; Pipy, B; Souqual, MC | 1 |
| Emilsson, A; Sundler, R; Wijkander, J | 2 |
| Balsinde, J; Diez, E; Fernández, B | 1 |
| Hiura, M; Ishibashi, S; Nakamura, M; Ohtsuka, T; Okamura, N; Ozawa, M | 1 |
| Akiba, S; Fujii, T; Sato, T | 5 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A | 1 |
| Davis, BB; Duniec, ZM; Eling, TE; Wong, YH; Zenser, TV | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y; Wheeler-Jones, CP | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y; Rao, GH; Sadowska, K; Wheeler-Jones, CP | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y; Sadowska, K; Wheeler-Jones, CP | 1 |
| Balsinde, J; Fernández, B | 1 |
| Blackham, A; Griffiths, RJ; Hallam, C; Mann, J; Mitchell, PD; Norris, AA; Simpson, WT | 1 |
| Marathe, SA; Nair, X; Quigley, JW; Stanley, PL; Steiner, SA; Tramposch, KM; Zusi, FC | 1 |
| Benistant, C; Rubin, R | 1 |
| Aizu, E; Kato, R; Nakadate, T; Yamamoto, S | 1 |
| Béréziat, G; Cherqui, G; Etienne, J; Kadiri, C; Masliah, J; Rybkine, T | 1 |
| Kitaoka, M; Kojima, I; Ogata, E | 1 |
| Coyne, DW; Mordhorst, M; Morrison, AR | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Hiura, M; Ishibashi, S; Nakamura, M; Ohtsuka, T; Okamura, N; Yoshida, K | 1 |
| Dani, GM; Englen, MD; Laegreid, WW; Leid, RW; Liggitt, HD; Silflow, RM; Taylor, SM | 1 |
| Fujiki, H; Hirasawa, N; Ohashi, M; Ohuchi, K; Ozeki, T; Tamura, T; Tsurufuji, S; Watanabe, M | 1 |
| Marshall, TM; Peters-Golden, M; Sporn, PH | 1 |
| Baldari, CT; Donati, D; Macchia, G; Massone, A; Parente, L; Telford, JL | 1 |
| Bonvini, E; DeBell, KE; Hoffman, T; Ponzoni, M | 1 |
| Dunlop, M; Metz, SA | 1 |
| Braun, DP; Casey, LC; Harris, JE; Siziopikou, KP | 1 |
| Seechurn, P; Thody, AJ | 1 |
| Aono, T; Hirota, K; Ikegami, H; Jikihara, H; Koike, K; Miyake, A; Tanizawa, O | 1 |
| Kajiyama, Y; Murayama, T; Nomura, Y; Takahashi, A | 1 |
| AbuBakar, S; Albrecht, T; Boldogh, I | 2 |
| Bühler, FR; Resink, TJ; Scott-Burden, T; Weber, E | 1 |
| Kajiyama, Y; Murayama, T; Nomura, Y | 1 |
| Masuda, Y; O'Brien, PJ; Takanaka, K; Taniguchi, K | 1 |
| Dunn, MJ; Simonson, MS | 1 |
| Axelrod, J; Brenneman, DE; Felder, CC; Fitzgerald, S; Kanterman, RY; Ma, AL | 1 |
| Edashige, K; Inoue, M; Inouye, B; Kobuchi, H; Matsuno, T; Orita, K; Sato, EF; Utsumi, K | 1 |
| Franke, T; Glusa, E; Markwardt, F; Nilius, B | 1 |
| Albertine, KH; Berd, D; Cerasoli, F; Gee, MH; Ishihara, Y; Peters, SP | 1 |
| Gallin, JI; Kleinberg, ME; Leto, T; Malech, HL; Nunoi, H; Rotrosen, D | 1 |
| Burger, HG; Farnworth, PG; Findlay, JK; Wang, QF | 1 |
| Jarvis, WD; Judd, AM; Kuan, SI; Kubota, T; Macleod, RM; Spangelo, BL | 1 |
| Anderson, R; De Beer, FC; Fridkin, M; Myer, MS; Rosen, O; Shephard, EG; Strachan, AF | 1 |
| Axelrod, J; Felder, CC; Kanterman, RY | 1 |
| McCaffrey, PG; Oghiso, Y; Sato, H; Shibata, Y | 1 |
| Chao, W; Hanahan, DJ; Liu, H; Olson, MS | 1 |
| Doussiere, J; Laporte, F; Vignais, PV | 1 |
| Britigan, BE; Hamill, DR | 1 |
| Carey, F; Forder, RA; Hoult, JR; Moroney, MA | 1 |
| Crews, FT; Heiman, AS | 1 |
| Pandol, SJ; Schoeffield, MS | 1 |
| DeLeo, VA; Hanson, D; Harber, LC; Horlich, H; Scheide, S; Southern, W; Weinstein, IB | 1 |
| Fairley, JA; Marcelo, CL; Weiss, J | 1 |
| Hansen, HS; Jacobsen, S; Jensen, B | 1 |
| Bonvini, E; Hoffman, T; Jennings, MK; Lizzio, EF; Marshall, LA; Ting, A | 1 |
| Aussel, C; Fehlmann, M | 1 |
| Fürstenberger, G; Gschwendt, M; Herald, CL; Kittstein, W; Marks, F; Pettit, GR; Rogers, M; Rose-John, S | 1 |
| Metz, SA | 3 |
| Olson, DM; Zakar, T | 1 |
| Dawson, G; McAtee, P | 1 |
| Jungblut, P; Schultz, G; Seifert, R | 1 |
| Molderings, GJ; Schümann, HJ | 1 |
| Kakkar, VV; Krishnamurthi, S; Patel, Y | 1 |
| Fuse, I; Iwanaga, T; Tai, HH | 1 |
| Leung, PC; Wang, J; Yuen, BH | 1 |
| Horiguchi, J; Imamura, K; Kufe, D; Luebbers, R; Spriggs, D; Stone, R | 1 |
| Molski, TF; Sha'afi, RI; Tao, W | 1 |
| Lee, V; Leung, PC; Wang, J | 1 |
| Aubry, H; Froissart, P; Proulx, P; Unligil, P | 1 |
| Nakadate, T | 1 |
| Calhoun, W; Carlson, RP; Chang, JY; Datko, L; Kreft, AF; Musser, JH; O'Neill-Davis, L | 1 |
| Judd, AM; Login, IS; MacLeod, RM | 1 |
| Englen, MD; Laegreid, WW; Leid, RW; Liggitt, HD; Silflow, RM; Straub, KM; Taylor, SM | 1 |
| Davis, BB; Wong, YH; Zenser, TV | 1 |
| Hall, A; Marshall, CJ; Morris, JD; Price, BD | 1 |
| Gustafson, C; Tagesson, C | 1 |
| Fujiki, H; Hirasawa, N; Ohashi, M; Ohuchi, K; Tamura, T; Tsurufuji, S; Watanabe, M | 1 |
| Cockcroft, S; Stutchfield, J | 1 |
| Albright, E; Field, FJ; Mathur, SN | 1 |
| Bonne, C; Dornand, J; Emerit, I; Giroud, JP; Griswold, DE; Latour, E; Modat, G; Muller, A; Roch, M; Tissie, G | 1 |
| Kanzaki, T; Morisaki, N; Saito, Y; Yoshida, S | 1 |
| Ailhaud, G; Gaillard, D; Lagarde, M; Négrel, R | 1 |
| Breeze, RG; Evermann, JR; Laegreid, WW; Leid, RW; Liggitt, HD; Silflow, RM; Taylor, SM | 1 |
| Kurokawa, S; Mok, LL; Reynolds, EE | 1 |
| King, CH; Kusner, DJ | 1 |
| Brown, JH; Goldstein, D; Martinson, EA | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Hamasaki, T; Kobayashi, M; Sakano, T; Sakura, N; Ueda, K; Usui, T | 1 |
| Ishikawa, Y; Ogawa, A; Sasakawa, S | 1 |
| Czerniecki, BJ; Witz, G | 1 |
| Kienast, J; Lenfers, B; van de Loo, J | 1 |
| Axelrod, J; Felder, CC; Kanterman, RY; Ma, AL | 1 |
| Chappell, JB; Henderson, LM; Jones, OT | 1 |
| Blackham, A; Griffiths, RJ; Li, S; Wood, BE | 1 |
| Duell, EA; Elder, JT; Esmann, J; Fisher, GJ; Gupta, AK; Nickoloff, BJ; Talwar, HS; Voorhees, JJ | 1 |
| Denda, A; Eimoto, H; Kinugasa, T; Kitazawa, S; Konishi, Y; Takashima, Y; Tsujiuchi, T; Tsutsumi, M; Ura, H | 1 |
| Betts, WH; Cleland, LG; Hurst, NP; McColl, SR | 1 |
| Read, AM; Schrey, MP; Steer, PJ | 1 |
| Joseph, S; Kakkar, VV; Krishnamurthi, S | 3 |
| Balsinde, J; Diez, E; Schüller, A | 1 |
| Grinstein, S; Nasmith, PE | 2 |
| Coughlin, SR; Kacich, RL; Williams, LT | 1 |
| Iizuka, T; Ishimura, Y; Kanegasaki, S; Makino, R; Tanaka, T | 1 |
| Baldwin, JK; Cameron, GS; Fischer, SM; Jasheway, DW; Patrick, KE | 1 |
| Axelrod, J; Bonner, TI; Brann, MR; Buckley, NJ; Conklin, BR; Ma, AL | 1 |
| Ida, E; Onoue, K; Sakata, A; Tominaga, M; Yamasaki, H | 1 |
| Fujiki, H; Levine, L | 1 |
| Fujiki, H; Levine, L; Xiao, D | 1 |
| Fujiki, H | 1 |
| Ho, AK; Klein, DC | 1 |
| Hall, ER; Sanduja, SK; Trial, J | 1 |
| Levine, L; Rigas, A; Snoek, GT | 1 |
| Berton, G; Valletta, EA | 1 |
| Covington, M; Newton, RC | 1 |
| Canonico, PL; Judd, AM; Koike, K; MacLeod, RM; Valdenegro, CA | 1 |
| Colburn, NH; Gindhart, TD; Nakamura, Y | 1 |
| Bender, JG; Van Epps, DE | 1 |
| Feinstein, MB; Molski, TF; Naccache, PH; Sha'afi, RI; Volpi, M | 1 |
| Benveniste, R; Ilekis, J | 1 |
| Homma, Y; Ishitoya, J; Kato, M; Nagai, Y; Takenawa, T | 1 |
| Adams, LM; Fischer, SM | 1 |
| Feinstein, MB; Molski, TF; Naccache, PH; Sha'afi, RI; Shefcyk, J; Tao, W; Volpi, M; White, JR; Yassin, R | 1 |
| Hara, T; Hayashida, M; Niijima, T; Umeda, T | 1 |
| Altom, MG; Nanda, SK; Schultz, RM | 1 |
| Ohta, H; Okajima, F; Ui, M | 1 |
| Chovaniec, ME; Cohen, HJ; Takahashi, K; Whitin, JC | 1 |
| Cerutti, PA; Emerit, I; Khan, SH | 1 |
| Bell, RM; Lambeth, JD; Merrill, AH; Olcott, MC; Wilson, E | 1 |
| Bell, AL; Betts, WH; Cleland, LG; French, JK; Hurst, NP; Nuki, G; O'Donnell, ML | 1 |
| Maridonneau-Parini, I; Tauber, AI; Tringale, SM | 1 |
| Cleland, LG; Hurst, NP; McColl, SR | 1 |
| Friesen, HG; Gertler, A | 1 |
| Cohen, HJ; Takahashi, K; Whitin, JC | 1 |
| Nishihira, J; O'Flaherty, JT | 1 |
| Giedd, KN; Haines, KA; Korchak, HM; Rich, AM; Weissmann, G | 1 |
| Henderson, WR; Liles, WC; Meier, KE | 1 |
| Ida, E; Onoue, K; Sakata, A; Tominaga, M | 1 |
| Miyahara, M; Okimasu, E; Utsumi, K; Watanabe, S | 1 |
| Catt, KJ; Chang, JP; Graeter, J | 2 |
| Besemfelder, E; Fürstenberger, G; Gschwendt, M; Hagedorn, H; Hull, WE; Kittstein, W; Marks, F; Opferkuch, HJ | 1 |
| Dyer, EL; Snapper, JR | 1 |
| Fuse, I; Hanano, M; Hattori, A; Higashihara, M; Koike, T; Nagayama, R; Shibata, A; Takahashi, H; Takeshige, T; Takizawa, S | 1 |
| Becker, EL; Feinstein, MB; Molski, TF; Naccache, PH; Sha'afi, RI; Shefcyk, J; Volpi, M; White, JR; Yassin, R | 1 |
| Adams, DO; Hamilton, T; Lewis, JG | 1 |
| Emilsson, A; Sundler, R | 1 |
| Carroll, RC; Cox, AC | 1 |
| Desforges, JF; Snyder, DS | 1 |
| Andrews, PC; Babior, BM; Hayakawa, T; Suzuki, K; Suzuki, S | 1 |
| Daniel, LW; Waite, M; Wykle, RL | 1 |
| Wong, T; Wu, MC; Yunis, AA; Ziboh, VA | 1 |
| Nathan, CF; Tsunawaki, S | 1 |
| Irvine, RF; Pollock, WK; Rink, TJ | 1 |
| Mizusaki, S; Okamoto, H; Saito, Y; Yoshida, D | 1 |
| Armato, U; Marchesini, C; Paccagnella, L; Romano, F | 1 |
| Clark, MR; Kawai, Y | 1 |
| Lands, WE; Marshall, PJ | 1 |
| Andreis, PG; Armato, U; Marchesini, C; Paccagnella, L; Romano, F | 1 |
| Schenkein, HA | 1 |
| Kvedar, J; Levine, L | 1 |
| Glomset, JA; Goerig, M; Habenicht, AJ; Heitz, R; Katus, H; Kommerell, B; Zeh, W; Ziegler, R | 1 |
| Blumberg, PM; Cox, JA; Jeng, AY; Tauber, AI | 1 |
| Gigli, I; Lim, HW; Wasserman, SI | 1 |
| Civan, MM; Mauro, T; O'Brien, TG | 1 |
| Cerutti, P; Emerit, I; Jörg, A; Kozumbo, WJ; Muehlematter, D | 1 |
| Daniel, LW; Parker, J; Waite, M | 1 |
| Espe, U; Fürstenberger, G; Kaszkin, M; Kinzel, V; Marks, F | 1 |
| Dunlop, M; Grigoriou, S; Handelsman, D; Tuch, BE; Turtle, JR; Williams, PF | 1 |
| Leung, PC; Minegishi, T; Wang, J | 1 |
| Aoyagi, T; Fukaya, T; Koizumi, H; Nemoto, O; Suya, H | 1 |
| Fischer, SM; Fürstenberger, G; Marks, F; Slaga, TJ | 1 |
| Lackie, JM; Lawrence, AJ | 1 |
| O'Brian, CA; Weinstein, IB | 1 |
| Faberman, J; Fürstenberger, G; Ganss, M; Marks, F; Richter, H; Rogers, M | 1 |
| Christensen, SB; Fujiki, H; Hirasawa, N; Ohuchi, K; Sugawara, T; Sugimura, T; Tsurufuji, S; Watanabe, M | 2 |
| Akimoto, K; Emoto, T; Hiraiwa, M; Kasai, K; Shimoda, S; Takaoka, T | 1 |
| Didolkar, AK; Sundaram, K | 1 |
| Fuse, I; Tai, HH | 2 |
| Fritsch, H; Müller-Peddinghaus, R; Wurl, M | 1 |
| Blazek, E; Carlson, RP; Chang, J | 1 |
| Demers, LM; Veldhuis, JD | 1 |
| Dandona, P; Jeremy, J; Morrow, C; Murphy, S; Pearce, B | 1 |
| Baxter, CS; Lawrence, AT | 1 |
| Espe, U; Fürstenberger, G; Kaszkin, M; Kinzel, V; Richards, J | 1 |
| Shimizu, Y; Takasu, N; Yamada, T | 1 |
| Craven, PA; DeRubertis, FR; Patterson, MC | 1 |
| Burch, RM | 1 |
| Halenda, SP; Rehm, AG | 1 |
| Bonventre, JV; Kremer, SG; Kudlow, JE; Margolis, BL; Skorecki, KL | 1 |
| Leung, PC; Wang, J | 1 |
| Chapkin, RS; Erickson, KL; Somers, SD | 1 |
| Matsumoto, T; Sha'afi, RI; Tao, W | 1 |
| Anderson, KM; Harris, JE; Wiederhold, MD | 1 |
| Czerniecki, B; Gad, SC; Reilly, C; Witz, G | 1 |
| Adams, DO; Lewis, JG | 1 |
| Gliemann, J; Okuno, Y | 1 |
| Davis, BB; Thomasson, DL; Zenser, TV | 1 |
| Espe, U; Fürstenberger, G; Kaszkin, M; Kinzel, V | 1 |
| Catt, KJ; Chang, JP; Graeter, JS | 1 |
| Daniel, LW; Parker, J; Pettit, GR; Waite, M | 1 |
| Fujiki, H; Hirasawa, N; Ohuchi, K; Ozeki, T; Tsurufuji, S; Watanabe, M | 1 |
| Kamel, F; Kubajak, CL | 1 |
| Schimmel, RJ | 1 |
| Conney, AH; Huang, MT; Smart, RC; Wong, CQ | 1 |
| Cucuianu, MP; Deamer, DW; Edwards, B; Lascu, I | 1 |
| Hashimura, T; Kanamaru, H; Yoshida, O | 1 |
| Catt, KJ; Chang, JP; Morgan, RO | 1 |
| Das, UN | 1 |
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| Moreno, JJ; Sánchez, T | 3 |
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| Balboa, MA; Balsinde, J; Dennis, EA; Johnson, CA | 1 |
| Kim, JH; Kim, Y; Lee, BD; Lee, SD; Ryu, SH; Suh, PG | 1 |
| Florio, T; Giordano, G; Giusti, M; Schettini, G; Thellung, S; Valenti, S | 1 |
| Dartsch, D; Marotzki, S; Marquardt, H; Schäfer, W; Wölfle, D | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Chen, Y; Kapahi, P; Karin, M; Natoli, G; Rossi, A; Santoro, MG; Takahashi, T | 1 |
| Hayaishi, O; Ishimura, K; Kanaoka, Y; Mahmud, I; Ueda, N; Urade, Y; Yamaguchi, H; Yamamoto, K; Yamamoto, S; Yamashita, R | 1 |
| Eker, P; Garred, O; Llorente, A; Sandvig, K; van Deurs, B | 1 |
| Berezin, V; Bock, E; Kolkova, K; Novitskaya, V; Pedersen, N | 1 |
| Goto, K; Kuriyama, M; Saito, N; Sakai, N; Segawa, S; Shirai, Y | 1 |
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| Adam, D; Adam-Klages, S; Kreder, D; Krönke, M; Lüschen, S; Schneider-Brachert, W; Ussat, S | 1 |
| Ikegaya, H; Iwase, H; Kobayashi, M; Nakaya, H; Sakurada, K; Uemura, H; Yoshida, K | 1 |
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| Avis, IM; Cavanaugh, PF; Chen, Z; Hong, SH; Loukinova, E; Mulshine, JL; Ondrey, FG; Van Waes, C | 1 |
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| Bauer, CK; Schledermann, W; Schwarz, JR; Wulfsen, I | 1 |
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| Byron, KL; Li, Y; Maszak, G; Shiels, AJ | 1 |
| Hashimoto, T; Imamura, M; Inoguchi, T; Kakimoto, M; Nakashima, N; Nawata, H; Umeda, F; Yu, HY | 1 |
| Ban, HS; Kim, SY; Kim, YP; Lee, EB; Li, D; Lim, SS; Ohuchi, K; Shin, KH | 1 |
| Béraud, M; Courtade, M; Escoubet-Lozach, L; Frisach, MF; Lepert, JC; M'Rini, C; Pipy, B; Rey, A | 1 |
| Carbonell, T; Miret, S; Mitjavila, MT; Moreno, JJ; Sánchez, T | 1 |
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| Asaka, Y; Kodama, H; Lu, HW; Manabe, M; Masuoka, N; Sagara, Y; Sugahara, K | 1 |
| Atruz, OM; Chuchalin, AG; Selishcheva, AA; Skrjabin, GA; Sorokoumova, GM; Vasilenko, IA | 1 |
| Kodama, H; Ma, D; Sagara, Y; Sugahara, K; Zhang, J | 1 |
| de las Heras, B; Fernández, MA; García, MD; Sáenz, MT; Villar, A | 1 |
| Brunk, UT; Eaton, JW; Zhao, M | 1 |
| Habibi, HR; Pati, D | 1 |
| Kashiwagi, K; Kuriyama, M; Saito, N; Sakai, N; Shirai, Y | 1 |
| Furue, M; Goto, Y; Hayashi, H; Kogawa, N; Takahashi, O; Tsuchiya, M; Uchi, H; Watanabe, N | 1 |
| Jennings, S; Lee, V; Ng, LL; Pettit, AI; Quinn, PA; Wong, RK | 1 |
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| Gross, RW; Han, X; Jenkins, CM; Mancuso, DJ | 1 |
| Bakó, G; Csermely, P; Csongor, J; Illés, A; Kovács, I; Sipka, S; Szántó, S; Szegedi, G | 1 |
| Kennedy, CR; Lemieux, LI; Rahal, SS | 1 |
| Ban, HS; Kim, YP; Lee, S; Ohuchi, K; Shin, KH; Yamaki, K | 1 |
| Krugh, BW; Liao, Z; Simoni, A; Simonyi, A; Sun, GY; Weisman, GA; Weng, YI; Xu, J | 1 |
| Chen, G; Kodama, H; Lu, H; Manabe, M; Wang, C; Yamashita, K | 1 |
| Giner, RM; Máñez, S; Recio, MC; Ríos, JL; Sala, A; Schinella, GR | 1 |
| Cox, R; Oleksiak, MF; Parker, C; Qu, W; Stegeman, JJ; Wu, S; Zeldin, DC | 1 |
| Backhouse, N; Bórquez, J; Delporte, C; Loyola, A; Salinas, P; San-Martín, A | 1 |
| Fresco, P; Gonçalves, J; Pinto, E; Pinto, M; Saraiva, L; Sousa, E | 1 |
| Fujita, T; Goto, A; Hara, C; Horita, S; Kunimi, M; Seki, G; Sugaya, T; Yamada, H; Zheng, Y | 1 |
| Gábor, M | 1 |
| Choy, PC; Hatch, GM; Jiang, YJ; Lu, B | 1 |
| Chen, G; Kitaoka, N; Kodama, H; Lu, H; Manabe, M; Sagara, Y; Song, S; Wang, Z; Xu, S | 1 |
| Chi, YS; Kim, HP; Lim, H; Park, H | 1 |
| Moreno, JJ | 1 |
| de La Puerta Vázquez, R; Martínez-Domínguez, E; Ruiz-Gutiérrez, V; Sánchez Perona, J | 1 |
| Ho, CT; Hong, J; Hou, Z; Huang, MT; Lambert, JD; Rosen, RT; Ryu, JH; Sang, S; Stark, RE; Tian, S; Yang, CS | 1 |
| Baik, KU; Cho, JY; Kim, HP; Lee, JG; Park, JS; Park, MH; Yoo, ES | 1 |
| Bae, DS; Bae, YS; Ha, KS; Lee, IH; Rhee, SG; Suh, PG; You, JO | 1 |
| Delgado, R; Delporte, C; García, D; Garrido, G; González, D; Lemus, Y; Lodeiro, L; Núñez-Sellés, AJ; Quintero, G | 1 |
| Fisher, PB; Laskin, JD; Mufson, RA; Weinstein, IB | 1 |
| Cederbaum, AI; Jimenez-Lopez, JM | 1 |
| Azuma, C; Murayama, T; Shimizu, M; Taniguchi, T | 1 |
| Benedyk, M; Dagher, MC; Doussiere, J; Kerkhoff, C; Nacken, W; Sopalla, C | 1 |
| Creer, MH; Kell, PJ; McHowat, J; Meyer, MC | 1 |
| Brüne, B; Cantoni, O; Cerioni, L; Guidarelli, A; Tommasini, I | 1 |
| Chen, YC; Shen, SC; Tsai, SH | 1 |
| Adzet, T; Cañigueral, S; Marín, E; Parella, T; Pérez-García, F | 1 |
| Baumruker, T; Billich, A; Bornancin, F; Huesken, D; Mechtcheriakova, D; Natt, F | 1 |
| Bae, K; Chang, HW; Choi, YH; Kang, SS; Kim, HP; Son, KH | 1 |
| Dinauer, MC; Kim, C | 1 |
| Cannizzaro, C; D'Amico, M; Martire, M; Preziosi, P | 1 |
| Dushenkov, S; Ghai, G; Ho, CT; Huang, MT; Liu, Y; Lo, CY; Ramji, D | 1 |
| Kodama, H; Liu, G; Manabe, M; Song, SJ; Yagi-Chaves, SN; Yamashita, K | 1 |
| Aguirre, MC; Alegría, S; Backhouse, N; Cassels, BK; Delporte, C; Erazo, S; Letelier, ME; Negrete, R; Silva, X | 1 |
| Chen, BQ; Cui, XY; Kim, JH; Lee, BC; Piao, HS; Pyo, HB; Yun, YP; Zhang, YH; Zhao, X | 1 |
| Delgado, R; Delporte, C; Garrido, G; González, D; Lemus, Y | 1 |
| Fujino, H; Hirabayashi, T; Murayama, T; Nakamura, H; Shimizu, M; Taniguchi, T | 1 |
| Choi, WS; Ha, CG; Her, E; Jun, SH; Kim, BK; Kim, NW; Kim, YM; Ko, NY; Lee, JH; Lee, JM; Lee, MH; Lee, SH; Mun, SH; Park, SH | 1 |
| Dave, V; Joshi, M; Kale, M; Misar, AV; Mujumdar, AM | 1 |
| Bíró, T; Griger, Z; Kovács, I; Kovács, L; Páyer, E; Sipka, S; Tóth, BI | 1 |
| Abayasekara, DR; Cheng, Z; Flint, AP; Marshall, E; Sheldrick, EL; Wathes, DC | 1 |
| Giner, RM; Hernández, V; Máñez, S; Recio, MC; Ríos, JL | 1 |
| Bruckner, G; Brugós, L; Kovács, I; Sipka, S; Szántó, S; Szegedi, G; Szentmiklósi, AJ | 1 |
| Friis, MB; Lambert, IH; Vorum, KG | 1 |
| Gelb, MH; Gijón, MA; Leslie, CC; Qiu, ZH; Spencer, DM; Tucker, DE | 1 |
| Inoue, T; Nakayama, K; Nitto, T; Node, K | 1 |
| Delporte, C; Dieguez, R; Garrido, G; Hernández, I; Márquez, L; Martínez, I; Molina-Torres, J; Prieto, S | 1 |
| Jalagadugula, G; Kaur, G; Mao, G; Rao, AK | 1 |
| Boller, S; Cabrini, DA; Marques, MC; Otuki, MF; Pizzolatti, MG; Santos, EP; Soldi, C; Zampronio, AR | 1 |
| Hur, S; Kim, TY; Lee, YS; Yang, JH; Yoo, H | 1 |
| Hemalatha, S; Khosa, RL; Pandurangan, A | 1 |
| Abe, H; Chen, G; Chi, H; He, W; Kodama, H; Wei, S; Yamashita, K; Yokoyama, M | 1 |
| Chowdhury, AA; Ishikawa, T; Jisaka, M; Nagaya, T; Nishimura, K; Rahman, MS; Shono, F; Yokota, K | 1 |
| Ho, CT; Huang, MT; Lin, CC; Liu, Y | 1 |
| Bernad, J; Dardenne, C; Del Bufalo, A; Martinozzi-Teissier, S; Meunier, JR; Pipy, B; Rousset, F; Verda, D | 1 |
| Cayme, M; Cho, Y; Fukuyo, Y; Hiroki, S; Kanai, Y; Konoki, K; Koshino, H; Yotsu-Yamashita, M | 1 |
| Biavatti, MW; Buchi, DF; Cabrini, DA; Horinouchi, CD; Loddi, AM; Neris, R; Otuki, MF; Pietrovski, EF; Rauh, LK; Souza-Fonseca-Guimarães, F | 1 |
| Bohrman, JS; Fischer, SM; Gleason, GL; Hardin, LG; Slaga, TJ | 1 |
| Ibrahim, B; Sowemimo, A; Van de Venter, M; van Rooyen, A | 1 |
| Dircks, BH; Mischke, R; Schuberth, HJ | 1 |
| Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP | 1 |
| Last, V; Werling, D; Williams, A | 1 |
| Cabrini, DA; Facundo, VA; Horinouchi, CD; Mendes, DA; Otuki, MF; Pietrovski, EF; Santos, AR; Soley, Bda S | 1 |
| Chen, YC; Chien, CC; Shen, SC; Wu, MS; Wu, WS; Yang, LY | 1 |
| Tseng, CL; Wei, JW | 1 |
| Barriga, A; Castro, C; de Las Heras, B; Delporte, C; Figueroa, C; Hortelano, S; Silva, X; Valenzuela-Barra, G | 1 |
| Cao, W; Cao, WX; Feng, ZQ; Guan, X; Guo, JW; Han, QJ; Li, B; Li, YY; Qin, J; Wang, Y; Zhang, HJ; Zhang, MJ; Zhou, J | 1 |
| Abidi, L; Avesi, L; Faizi, S; Farooq, AD; Mirza, T; Naqvi, S; Siddiqui, F | 1 |
| Fukasaku, M; Kimura, J; Yamaguchi, O | 1 |
| Golenkina, EA; Livenskyi, AD; Romanova, YM; Sokolov, AV; Sud'ina, GF; Viryasova, GM | 1 |
| Chen, JN; Hu, Z; Ip, SP; Lai, XP; Lin, ZX; Su, ZR; Xian, YF | 1 |
| Baretta, IP; Brandenburg, MM; Cabrini, DA; Costa, SCA; Meinerz, CC; Otuki, MF; Pawloski, PL; Rocha, FG; Soley, BDS | 1 |
| Adolf, J; Gollowitzer, A; Kipp, AP; Koeberle, A; Koeberle, SC; Schädel, P; Schwarz, M; Weidenbach, LM; Werz, O; Wolfram, T | 1 |
11 review(s) available for tetradecanoylphorbol acetate and arachidonic acid
| Article | Year |
|---|---|
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
Topics: Arachidonic Acid; Arachidonic Acids; Carcinogens; Curcumin; Diet; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1991 |
Immunologic aspects of preterm labor.
Topics: Amnion; Arachidonic Acid; Chorioamnionitis; Cytokines; Dinoprostone; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Lipopolysaccharides; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Uterus | 1991 |
The mechanism of skin tumor promotion caused by phorbol esters: possible involvement of arachidonic acid cascade/lipoxygenase, protein kinase C and calcium/calmodulin systems.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calmodulin; Lipoxygenase; Mice; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1989 |
Perspectives in diabetes. Is protein kinase C required for physiologic insulin release?
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Diglycerides; Enzyme Activation; Insulin; Insulin Secretion; Islets of Langerhans; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Metabolites of arachidonic acid in the pathophysiology of the pulmonary circulation.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Endotoxins; Escherichia coli; Lung; Microcirculation; Pulmonary Circulation; Tetradecanoylphorbol Acetate; Thromboxane B2; Vascular Resistance; Vasoconstriction | 1982 |
Multistage tumor promotion in skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Humans; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Effects of tumor promoters on arachidonic acid metabolism by cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cell Line; Cycloheximide; Dinoprostone; Growth Substances; Humans; Indomethacin; Lipid Metabolism; Male; Peptide Hydrolases; Phorbols; Prostaglandins; Prostaglandins E; Tetradecanoylphorbol Acetate; Time Factors; Vitamin A; Vitamin E | 1982 |
Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells.
Topics: Animals; Arachidonic Acid; Cell Differentiation; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Dietary Fats; Enzyme Activation; Epidermal Growth Factor; Epithelium; ErbB Receptors; Fatty Acids, Unsaturated; Female; Isoenzymes; Linoleic Acid; Linoleic Acids; Mammary Glands, Animal; Mice; Models, Biological; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Calcitriol; Carcinogens; Cell Differentiation; Chemoprevention; Curcumin; Diet; Humans; Mice; Neoplasms, Experimental; Tea; Tetradecanoylphorbol Acetate; Tretinoin | 1997 |
The regulation of cyclooxygenase-1 and -2 in knockout cells and cyclooxygenase and fever in knockout mice.
Topics: Animals; Arachidonic Acid; Brain; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dinoprostone; Fever; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mice; Mice, Knockout; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Substrate Specificity; Tetradecanoylphorbol Acetate | 2000 |
Models of acute inflammation in the ear.
Topics: Alkynes; Animals; Anthralin; Arachidonic Acid; Cantharidin; Capsaicin; Carrageenan; Croton Oil; Dermatitis; Disease Models, Animal; Diterpenes; Edema; Foot; Inflammation; Irritants; Male; Mice; Models, Animal; Mustard Plant; Otitis Externa; Plant Extracts; Plant Oils; Rats; Reproducibility of Results; Terpenes; Tetradecanoylphorbol Acetate; Zymosan | 2003 |
755 other study(ies) available for tetradecanoylphorbol acetate and arachidonic acid
| Article | Year |
|---|---|
Regulation of gap junctional communication in Syrian hamster embryo cells by retinoic acid and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Cell Communication; Cell Line; Cell Line, Transformed; Cricetinae; Cyclic AMP; Embryo, Mammalian; Epidermal Growth Factor; Intercellular Junctions; Mesocricetus; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
Interleukin 1 and phorbol 12-myristate 13-acetate induce collagenase and PGE2 production through a PKC-independent mechanism in chondrocytes.
Topics: Alkaloids; Animals; Arachidonic Acid; Cartilage, Articular; Cattle; Cell Compartmentation; Cells, Cultured; Dinoprostone; Enzyme Induction; Interleukin-1; Microbial Collagenase; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of release of arachidonic acid, superoxide, and IL-1 from human monocytes by monoclonal anti-HLA class II antibodies: effects at proximal and distal points of inositol phospholipid hydrolysis pathway.
Topics: Antibodies, Monoclonal; Arachidonic Acid; Calcium; Cyclic AMP; Histocompatibility Antigens Class II; Humans; Hydrolysis; In Vitro Techniques; Interleukin-1; Ionomycin; Monocytes; Phosphatidylinositols; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Altered regulation of arachidonic acid metabolism by SV40 immortalized human urothelial cells.
Topics: Arachidonic Acid; Aspirin; Bradykinin; Calcimycin; Cell Line, Transformed; Dinoprostone; Diterpenes; Microsomes; Prostaglandin-Endoperoxide Synthases; Simian virus 40; Terpenes; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Effects of novel synthesized retinobenzoic acid (Am-80) on adenylate cyclase and arachidonic acid release in pig epidermis.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Benzoates; Cyclic AMP; In Vitro Techniques; Skin; Swine; Tetradecanoylphorbol Acetate; Tetrahydronaphthalenes | 1992 |
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester.
Topics: Arachidonic Acid; Aristolochic Acids; Calcimycin; Diglycerides; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenanthrenes; Phosphatidate Phosphatase; Phospholipase D; Phospholipases A; Phospholipases A2; Polymers; Prostaglandins B; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Calcium; Dose-Response Relationship, Drug; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes.
Topics: alpha 1-Antichymotrypsin; Arachidonic Acid; Calcium; Cell Membrane; Concanavalin A; Humans; In Vitro Techniques; Ionomycin; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Different guanosine triphosphate-binding proteins couple vasopressin receptor to phospholipase C and phospholipase A2 in glomerular mesangial cells.
Topics: Adenosine Diphosphate Ribose; Animals; Arachidonic Acid; Calcium; Cells, Cultured; Glomerular Mesangium; GTP-Binding Proteins; Kinetics; Male; Pertussis Toxin; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Tetradecanoylphorbol Acetate; Type C Phospholipases; Vasopressins; Virulence Factors, Bordetella | 1992 |
Interleukin 1-stimulated prostacyclin synthesis in endothelium: lack of phospholipase C, phospholipase D, or protein kinase C involvement in early signal transduction.
Topics: Arachidonic Acid; Cells, Cultured; Cyclic AMP; Egtazic Acid; Endothelium, Vascular; Epoprostenol; Humans; Interleukin-1; Phospholipase D; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Activation of protein kinase C by phorbol esters and arachidonic acid required for the optimal potentiation of glutamate exocytosis.
Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Cell Membrane; Drug Synergism; Electrophysiology; Enzyme Activation; Exocytosis; Glutamates; Glutamic Acid; Male; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1992 |
Regulation of arachidonate-mobilizing phospholipase A2 by phosphorylation via protein kinase C in macrophages.
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Isoenzymes; Kinetics; Macrophages; Mice; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Low concentrations of sodium azide specifically inhibit a thromboxane A2 pathway in human platelets.
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acid; Aspirin; Azides; Blood Platelets; Calcium; Collagen; Energy Metabolism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Myosin-Light-Chain Kinase; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Secretory Rate; Serotonin; Sodium Azide; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Stimulation of prostaglandin production in rat thymic epithelial cells by protein kinase C mediated activation of phospholipase A2.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Enzyme Activation; Epithelium; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Thymus Gland | 1992 |
Potencies of protein kinase C inhibitors are dependent on the activators used to stimulate the enzyme.
Topics: Animals; Arachidonic Acid; Brain; Calcium; Dynamins; Enzyme Activation; Enzyme Inhibitors; GTP Phosphohydrolases; Histones; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Phosphatidylserines; Phosphoproteins; Protein Kinase C; Proteins; Rats; Synaptosomes; Tetradecanoylphorbol Acetate | 1992 |
The regulation of prostaglandin biosynthesis in cells derived from human gestational tissues: effects of fetal calf serum.
Topics: Amnion; Arachidonic Acid; Chorion; Culture Media; Decidua; Dinoprostone; Epidermal Growth Factor; Extraembryonic Membranes; Female; Humans; In Vitro Techniques; Interleukin-1; Ionomycin; Pregnancy; Tetradecanoylphorbol Acetate | 1992 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Female; Lipoxygenase; Mice; Phenols; Prostaglandin-Endoperoxide Synthases; Skin; Skin Neoplasms; Tea; Tetradecanoylphorbol Acetate | 1992 |
Anthralin, a non-TPA type tumor promoter, synergistically enhances phorbol ester-caused prostaglandin E2 release from primary cultured mouse epidermal cells.
Topics: Animals; Anthralin; Arachidonic Acid; Carcinogens; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Drug Synergism; Epidermis; Mice; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1992 |
Phosphatidylinositol hydrolysis by phospholipase A2 and C activities in human peripheral blood neutrophils.
Topics: Arachidonic Acid; Calcimycin; Calcium Chloride; Cell Membrane; Chromatography, Thin Layer; Cytosol; Deoxycholic Acid; Detergents; Edetic Acid; Humans; Kinetics; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Octoxynol; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Polyethylene Glycols; Stearic Acids; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
The novel natural product YM-26567-1 [(+)-trans-4-(3-dodecanoyl-2,4,6- trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman]: a competitive inhibitor of group II phospholipase A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Binding, Competitive; Chromans; Edema; Kinetics; Mice; Phospholipases A; Phospholipases A2; Rabbits; Tetradecanoylphorbol Acetate | 1992 |
Inhibition by protein kinase C activation of melittin-induced arachidonic acid release in PC12 pheochromocytoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Kinetics; Melitten; Neurons; PC12 Cells; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Possible involvement of arachidonic acid metabolites in the synergistic action of endothelial mitogenesis by basic fibroblast growth factor and phorbol ester.
Topics: Arachidonic Acid; Cell Division; Cells, Cultured; DNA Replication; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Mitosis; Protein Kinase C; Tetradecanoylphorbol Acetate; Umbilical Veins | 1992 |
Phospholipase activation during monocyte adherence and spreading.
Topics: Acetophenones; Arachidonic Acid; Calcium; Cell Adhesion; Cells, Cultured; Egtazic Acid; Enzyme Activation; Humans; Monocytes; Phospholipases; Tetradecanoylphorbol Acetate | 1992 |
Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Calcimycin; Cyclooxygenase Inhibitors; Dermatitis; Edema; Imidazoles; Lipoxygenase Inhibitors; Male; Mice; Molecular Structure; Phospholipases A; Pyridines; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1992 |
Cell response kinetics: the phenomenon of supercooperativity in aggregation of human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Calcimycin; Epinephrine; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Tetradecanoylphorbol Acetate; Thimerosal | 1992 |
Transduction of a signal for arachidonic acid metabolism by untriggered CSF-1 receptor induces an opposite effect to that induced by CSF-1 receptor and its ligand: separate regulation of phospholipase A2 and cyclooxygenase by CSF-1 receptor/CSF-1.
Topics: Animals; Annexins; Arachidonic Acid; Calcium-Binding Proteins; Cinnamates; Dinoprostone; Hematopoietic Stem Cells; Ionomycin; Macrophage Colony-Stimulating Factor; Membrane Lipids; Mice; Phospholipases A; Phospholipases A2; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Proteins; Signal Transduction; Sulfides; Tetradecanoylphorbol Acetate; Zymosan | 1992 |
Bombesin stimulates the rapid activation of phospholipase A2-catalyzed phosphatidylcholine hydrolysis in Swiss 3T3 cells.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bombesin; Calcium; Calcium-Transporting ATPases; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Activation; Hydrolysis; Kinetics; Lysophosphatidylcholines; Mice; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1992 |
Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium.
Topics: Aequorin; Affinity Labels; Alkaloids; Arachidonic Acid; Calcimycin; Calcium; Cations, Divalent; Down-Regulation; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Humans; Inositol Phosphates; Luminescent Measurements; Protein Kinase C; Radioimmunoassay; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Priming of human polymorphonuclear leukocytes with granulocyte-macrophage colony-stimulating factor involves protein kinase C rather than enhanced calcium mobilisation.
Topics: Alkaloids; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcium; Cations, Divalent; Chromatography, High Pressure Liquid; Cycloheximide; Dactinomycin; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ionomycin; Leukotrienes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Sequential incorporation of 3H- and 14C-arachidonic acid during 24 h in rabbit colonic explants cultured in vitro.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Compartmentation; Colon; Culture Techniques; Dinoprostone; Intestinal Mucosa; Lipid Metabolism; Male; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases A; Rabbits; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Triggering by ATP of product release by mucous granules of the land slug Ariolimax columbianus.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Cytoplasmic Granules; Dinoprostone; Electric Stimulation; Ethylmaleimide; Furosemide; Ibuprofen; Indomethacin; Kinetics; Microscopy, Electron; Mollusca; Mucous Membrane; Nigericin; Pertussis Toxin; Tetradecanoylphorbol Acetate; Verapamil; Virulence Factors, Bordetella | 1992 |
Multiple signaling pathways for Cl(-)-dependent depolarization of mesangial cells: role of Ca2+, PKC, and G proteins.
Topics: Aluminum; Aluminum Compounds; Animals; Arachidonic Acid; Calcium; Chlorides; Down-Regulation; Electrophysiology; Fluorides; Glomerular Mesangium; GTP-Binding Proteins; Male; Nucleotides, Cyclic; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1992 |
Defining the role of protein kinase c in calcium-ionophore-(A23187)-mediated activation of phospholipase A2 in pulmonary endothelium.
Topics: Animals; Arachidonic Acid; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Phospholipases A; Phospholipases A2; Protein Kinase C; Pulmonary Artery; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Calcium rather than protein kinase C is the major factor to activate phospholipase D in FMLP-stimulated rabbit peritoneal neutrophils. Possible involvement of calmodulin/myosin L chain kinase pathway.
Topics: Animals; Arachidonic Acid; Calcium; Calmodulin; Enzyme Activation; In Vitro Techniques; Myosin-Light-Chain Kinase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C; Rabbits; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Cricetinae; Cytosol; Enzyme Activation; Epidermal Growth Factor; In Vitro Techniques; Phospholipases A; Phospholipases A2; Phosphoproteins; Phosphorylation; Platelet-Derived Growth Factor; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1992 |
Effects of okadaic acid on agonist-stimulated PGI2 production by rat liver cells (the C-9 cell line).
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Ethers, Cyclic; Kinetics; Liver; Okadaic Acid; Phosphoprotein Phosphatases; Platelet Activating Factor; Prostaglandins F; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Adrenergic regulation of intercellular communications between cultured striatal astrocytes from the mouse.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcium; Cell Communication; Cells, Cultured; Corpus Striatum; Cyclic AMP; Enzyme Activation; In Vitro Techniques; Inositol Phosphates; Intercellular Junctions; Mice; Norepinephrine; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1991 |
Polarized distribution of bradykinin receptors on airway epithelial cells and independent coupling to second messenger pathways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Membrane; Cells, Cultured; Dogs; Epithelium; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Kinetics; Receptors, Bradykinin; Receptors, Neurotransmitter; Second Messenger Systems; Tetradecanoylphorbol Acetate; Trachea | 1991 |
Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).
Topics: Arachidonic Acid; Arachidonic Acids; Calcium Channels; Calmodulin; Carbon Radioisotopes; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis; Epithelium; Humans; Hydrogen Peroxide; Intestinal Mucosa; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Luminol chemiluminescence and active oxygen generation by activated neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Azides; Cytochalasin B; Ferric Compounds; Free Radical Scavengers; Guinea Pigs; Hydroxides; Hydroxyl Radical; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Oxygen; Peroxidase; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Uric Acid; Zymosan | 1991 |
Isolation of human salivary polymorphonuclear leukocytes and their stimulation-coupled responses.
Topics: Annexins; Arachidonic Acid; Arachidonic Acids; Azides; Calcium; Calcium-Binding Proteins; Cell Membrane; Cell Separation; Humans; Kinetics; Luminescent Measurements; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Peroxidase; Saliva; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Differentiation-linked activation of the respiratory burst in a monocytic cell line (U937) via Fc gamma RII. A study of activation pathways and their regulation.
Topics: Antigens, Differentiation; Arachidonic Acid; Calcium; Cell Differentiation; Cyclic AMP; Eicosanoids; Gene Expression; Humans; In Vitro Techniques; Interferon-gamma; Isoenzymes; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Receptors, Fc; Receptors, Formyl Peptide; Receptors, IgG; Receptors, Immunologic; Respiratory Burst; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways.
Topics: Adenylyl Cyclases; Antigens, Differentiation, T-Lymphocyte; Arachidonic Acid; Calcium; CD3 Complex; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; Humans; In Vitro Techniques; Inositol Phosphates; Leukemia, T-Cell; Muromonab-CD3; Protein Kinase C; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Possible regulatory functions of protein kinase C-alpha and -epsilon isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis.
Topics: Amino Acid Sequence; Angiotensin II; Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Glomerular Mesangium; Hydrolysis; Immunoenzyme Techniques; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1991 |
Comparison of the role of protein kinase C in platelet functional responses induced by three different mechanisms, PAF, ionomycin and arachidonic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Feedback; Ionomycin; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Activation of a keratinocyte phospholipase A2 by bradykinin and 4 beta-phorbol 12-myristate 13-acetate. Evidence for a receptor-GTP-binding protein versus a protein-kinase-C mediated mechanism.
Topics: Animals; Arachidonic Acid; Bradykinin; Carbon Radioisotopes; Cell Line; Cholera Toxin; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Inositol Phosphates; Keratinocytes; Kinetics; Lysophosphatidylcholines; Mice; NAD; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Inhibition of prostaglandin E2 and superoxide anion production in rat peritoneal macrophages by the calcium antagonists nifedipine and nisoldipine.
Topics: Animals; Arachidonic Acid; Calcimycin; Dinoprostone; Fura-2; In Vitro Techniques; Macrophages; Male; Nifedipine; Nisoldipine; Peritoneal Cavity; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.
Topics: Animals; Arachidonic Acid; Azepines; Blood Platelets; Calcimycin; Chloroquine; Female; Kinetics; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Pyridinium Compounds; Rabbits; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Triazoles | 1991 |
Inhibitory effects of histamine H1 receptor blocking drugs on metabolic activations of neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Biotransformation; Calcimycin; Cell Survival; Histamine H1 Antagonists; Humans; In Vitro Techniques; Leukotrienes; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Chemiluminescence response and arachidonic acid metabolism of macrophages induced by gamma-hexachlorocyclohexane (lindane).
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Drug Synergism; Hexachlorocyclohexane; Luminescent Measurements; Macrophages; Mice; Prostaglandins; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C and cyclic AMP modulate thrombin-induced platelet-activating factor synthesis in human endothelial cells.
Topics: Acetyltransferases; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Humans; Iloprost; Ionomycin; Kinetics; Platelet Activating Factor; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition.
Topics: Alkaloids; Antibodies, Anti-Idiotypic; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Dose-Response Relationship, Drug; Histamine Release; Humans; Immunoglobulin E; Lung; Mast Cells; Protein Kinase C; Signal Transduction; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
The metabolic effects of guanyl nucleotides on rat pancreatic acini permeabilized with streptolysin O suggest a widespread use of G proteins.
Topics: Amylases; Animals; Arachidonic Acid; Bacterial Proteins; Calcium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; In Vitro Techniques; Inositol Phosphates; Male; Pancreas; Permeability; Rats; Rats, Inbred Strains; Streptolysins; Tetradecanoylphorbol Acetate | 1991 |
Arachidonic acid induces phosphorylation of an 18 kDa protein in electrically permeabilised rat islets of Langerhans.
Topics: Animals; Arachidonic Acid; Autoradiography; Densitometry; Electricity; Enzyme Activation; Islets of Langerhans; Phosphorylation; Protein Kinase C; Proteins; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate | 1992 |
Regulation of prostaglandin H synthase activity in dog urothelial cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dinoprostone; Dogs; Prostaglandin-Endoperoxide Synthases; Staurosporine; Tetradecanoylphorbol Acetate; Urinary Bladder | 1992 |
Protein kinase C promotes arachidonate mobilization through enhancement of CoA-independent transacylase activity in platelets.
Topics: Acyl Coenzyme A; Acyltransferases; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Coenzyme A; Diglycerides; Kinetics; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Differentiation-associated expression of prostaglandin H and thromboxane A synthases in monocytoid leukemia cell lines.
Topics: Arachidonic Acid; Calcimycin; Cell Differentiation; Granulocytes; Humans; Leukemia; Lipoxygenase; Monocytes; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Tretinoin; Tumor Cells, Cultured | 1991 |
Inhibition of PGE2 production in macrophages from vitamin E-treated rats.
Topics: Animals; Arachidonic Acid; Calcimycin; Cyclooxygenase Inhibitors; Dinoprostone; Macrophages; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Vitamin E | 1991 |
Regulation of arachidonic acid release in vascular endothelium. Ca(2+)-dependent and -independent pathways.
Topics: Alkaloids; Animals; Aorta; Arachidonic Acid; Bradykinin; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Lysophospholipids; Protein Kinase C; Sodium Fluoride; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Role of protein kinase C and Ca2+ in glucose-induced sensitization/desensitization of insulin secretion.
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Drug Administration Schedule; Glucose; Insulin; Insulin Secretion; Male; Protein Kinase C; Rats; Secretory Rate; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
A photometric assay for hydrogen peroxide production by polymorphonuclear leucocytes.
Topics: Arachidonic Acid; Glutathione Peroxidase; Glutathione Reductase; Humans; Hydrogen Peroxide; N-Formylmethionine Leucyl-Phenylalanine; NADP; Neutrophils; Photometry; Tetradecanoylphorbol Acetate | 1991 |
Oxysterol activation of arachidonic acid release and prostaglandin E2 biosynthesis in NRK 49F cells is partially dependent on protein kinase C activity [corrected].
Topics: Animals; Arachidonic Acid; Blood; Calcitriol; Calcium; Cell Line; Dinoprostone; Hydroxycholesterols; Ionomycin; Ketocholesterols; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1991 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Diethylcarbamazine; Disease Models, Animal; Dogs; Ethchlorvynol; Indomethacin; Leukotrienes; Lung; Male; Methacrylates; Neutrophils; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thromboxanes | 1991 |
Association of the crosslinked IgE receptor with the membrane skeleton is independent of the known signaling mechanisms in rat basophilic leukemia cells.
Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane; Cytoskeleton; Dinitrophenols; Immunoglobulin E; Inositol Phosphates; Ionomycin; Kinetics; Leukemia, Basophilic, Acute; Rats; Receptors, Fc; Receptors, IgE; Serotonin; Signal Transduction; Solubility; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Protein kinase C-mediated desensitization of the muscarinic response in rat lacrimal gland cells.
Topics: Acetylcholine; Alkaloids; Animals; Arachidonic Acid; Calcium; Diglycerides; Enzyme Activation; Feedback; Fura-2; In Vitro Techniques; Lacrimal Apparatus; Protein Kinase C; Rats; Receptors, Muscarinic; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Calcium-dependent eicosanoid metabolism by concanavalin A-stimulated human monocytes in vitro. Synergism with phorbol ester indicates separate regulation of leukotriene B4 synthesis and release.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Concanavalin A; Eicosanoids; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotriene B4; Monocytes; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate | 1991 |
Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Apomorphine; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine; Drug Synergism; Ergolines; Haloperidol; In Vitro Techniques; Melitten; Pertussis Toxin; Protein Kinase C; Quinpirole; Receptors, Dopamine; Sulpiride; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1991 |
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Curcumin; Dermatitis, Contact; Female; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Lipoxygenase; Mice; Peroxidases; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1991 |
4 Beta- and 4 alpha-12-O-tetradecanoylphorbol-13-acetate elicit arachidonate release from epidermal cells through different mechanisms.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cycloheximide; Dactinomycin; Dinoprostone; Down-Regulation; Epidermis; Mice; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Interference of xanthate compounds with phorbol ester TPA-induced changes of phospholipid metabolism: inhibition of prostaglandin production.
Topics: Arachidonic Acid; Arachidonic Acids; Bridged-Ring Compounds; Diglycerides; Dinoprostone; HeLa Cells; Humans; Norbornanes; Phospholipids; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 1991 |
Potentiation of arachidonic acid release by phorbol myristate acetate in platelets is not due to inhibition of arachidonic acid uptake or incorporation into phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Humans; In Vitro Techniques; Phospholipids; Tetradecanoylphorbol Acetate | 1991 |
Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Blotting, Northern; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Glomerular Mesangium; Indomethacin; Ketoconazole; Male; Masoprocol; Pyridines; Rats; Rats, Inbred WKY; RNA, Messenger; Tetradecanoylphorbol Acetate | 1991 |
Stimulation of prostaglandin H synthase mRNA levels and prostaglandin biosynthesis by phorbol ester: mediation by protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Enzyme Activation; Epithelial Cells; Epithelium; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Rats; RNA, Messenger; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Trachea | 1991 |
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Female; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Mass Spectrometry; Mice; Mice, Inbred C57BL; Skin; Stereoisomerism; Tetradecanoylphorbol Acetate | 1991 |
Absence of modulation of monokine production via endogenous cyclooxygenase or 5-lipoxygenase metabolites: MK-886 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid), indomethacin, or arachidonate fail to alter immunor
Topics: Analysis of Variance; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Concanavalin A; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Indoles; Indomethacin; Interleukin-1; Leukotriene Antagonists; Lipopolysaccharides; Monocytes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C.
Topics: Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Cytoplasm; Diglycerides; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Lipid Metabolism; Microscopy, Electron; Neutrophils; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Endogenous activation of prostaglandin synthesis in rabbit colonic explants cultured in vitro.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Fractionation; Cell Membrane; Cells, Cultured; Colon; Cycloheximide; Cytochalasin B; Dinoprostone; In Vitro Techniques; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Tetradecanoylphorbol Acetate | 1991 |
C20 polyunsaturated fatty acids and phorbol myristate acetate enhance agonist-stimulated synthesis of 1-radyl-2-acetyl-sn-glycero-3-phosphocholine in vascular endothelial cells.
Topics: Acetates; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cattle; Endothelium, Vascular; Fatty Acids, Unsaturated; Kinetics; Phosphatidylcholines; Sphingosine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Comparison of arachidonate metabolism by alveolar macrophages from bighorn and domestic sheep.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Disease Susceptibility; Female; Genetic Predisposition to Disease; Lipoxygenase; Macrophages; Male; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Respiratory Tract Infections; Sheep; Species Specificity; Tetradecanoylphorbol Acetate; Zymosan | 1991 |
Fate of exogenous and endogenous prostaglandins D2 and E2 in the perfused rat liver.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bile; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprostone; Kinetics; Liver; Perfusion; Prostaglandin D2; Rats; Tetradecanoylphorbol Acetate | 1991 |
Phorbol ester plus calcium ionophore induces release of arachidonic acid from membrane phospholipids of a human B cell line.
Topics: Arachidonic Acid; Arachidonic Acids; B-Lymphocytes; Calcimycin; Cell Line; Humans; Hydroxyeicosatetraenoic Acids; Membrane Lipids; Phospholipids; Protein Kinase C; Stearic Acids; Tetradecanoylphorbol Acetate | 1991 |
Characterization of phospholipase A2 in monocytic cell lines. Functional and biochemical aspects of membrane association.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cytosol; Edetic Acid; Enzyme Activation; Humans; Leukemia, Myeloid; Magnesium; Membrane Proteins; Phospholipases A; Phospholipases A2; Substrate Specificity; Tetradecanoylphorbol Acetate | 1991 |
Stimulatory effect of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal cell proliferation in vivo as compared to the effects of phorbol ester TPA.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Line; Female; Hyperplasia; Keratinocytes; Mice; Skin; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1991 |
Protein kinase C regulates MHC-class II expression on endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Endothelium; Histocompatibility Antigens Class II; Interferon-gamma; Isoquinolines; Myocardium; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Cyclooxygenase pathway mediates lung injury induced by phorbol and platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; In Vitro Techniques; Indomethacin; Lung; Lung Injury; Masoprocol; Perfusion; Platelet Activation; Prostaglandin-Endoperoxide Synthases; Pulmonary Edema; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1991 |
Release of arachidonic acid by complement C5b-9 complex in glomerular epithelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Complement Membrane Attack Complex; Cyclohexanones; Diglycerides; Edetic Acid; Egtazic Acid; Epithelium; Fatty Acids, Nonesterified; Kidney Glomerulus; Kinetics; Lipase; Lipoprotein Lipase; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Cellular mechanism of synergistic stimulation of PGE2 production by phorbol diester and Ca2+ ionophore A23187 in cultured Madin-Darby canine kidney cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Dinoprostone; Dogs; Drug Synergism; Kidney; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.
Topics: Animals; Arachidonic Acid; Bacterial Infections; Carbohydrate Conformation; Cell Line; Endotoxins; Escherichia coli; Hot Temperature; Humans; Lipid A; Lipopolysaccharides; Macrophages; Mice; Monocytes; Rhodobacter sphaeroides; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction.
Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; N-Formylmethionine Leucyl-Phenylalanine; Neomycin; Phospholipases A; Phospholipases A2; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlorides; Diarrhea; Enterotoxins; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance | 1991 |
Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638.
Topics: Arachidonic Acid; Cells, Cultured; Cinnamates; Dinoprostone; Humans; Indicators and Reagents; Interleukin-3; Ionomycin; Phenotype; Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Sulfides; Tetradecanoylphorbol Acetate; Transfection | 1991 |
Ionizing radiation at low doses induces inflammatory reactions in human blood.
Topics: Arachidonic Acid; Blood; Blood Cells; Calcimycin; Dose-Response Relationship, Radiation; Escherichia coli; Gamma Rays; Humans; Inflammation; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Radiation Dosage; Respiratory Burst; Saponins; Tetradecanoylphorbol Acetate | 1991 |
Evidence that arachidonic acid influences hen granulosa cell steroidogenesis and plasminogen activator activity by a protein kinase C-independent mechanism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Chickens; Cyclic AMP; Female; Granulosa Cells; In Vitro Techniques; Luteinizing Hormone; Plasminogen Activators; Progesterone; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Altered arachidonic acid metabolism during differentiation of the human monoblastoid cell line U937.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Fatty Acids; Humans; Intramolecular Oxidoreductases; Isomerases; Leukotrienes; Lipoxygenase; Models, Biological; Monocytes; Phospholipases A; Phospholipases A2; Phospholipids; Prostaglandin-E Synthases; Prostaglandins; Tetradecanoylphorbol Acetate | 1990 |
Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Fatty Acids; Humans; Isoquinolines; Linoleic Acid; Linoleic Acids; Neutrophils; Oleic Acid; Oleic Acids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
The ratio of macrophage prostaglandin and leukotriene synthesis is determined by the intracellular free calcium level.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Dinoprostone; Drug Synergism; Enzyme Activation; In Vitro Techniques; Indomethacin; Macrophages; Manganese; Mice; Mice, Inbred DBA; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; SRS-A; Tetradecanoylphorbol Acetate | 1990 |
1-naphthyl N-methyl carbamate effect on intra- and extracellular concentrations of arachidonic acid metabolites, and on the chemiluminescence generation by mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carbaryl; Cell Survival; Extracellular Space; Intracellular Fluid; Luminescent Measurements; Macrophages; Male; Mice; Oxidation-Reduction; Peritoneal Cavity; Tetradecanoylphorbol Acetate; Time Factors; Tritium; Zymosan | 1990 |
A glycerol ether induces mobilization and 12-lipoxygenation of arachidonic acid in macrophages. Synergistic effect on mobilization and induction of leukotriene C formation by activators of protein kinase C.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Diglycerides; Dinoprostone; Drug Synergism; Enzyme Activation; Glyceryl Ethers; Hydroxyeicosatetraenoic Acids; Kinetics; Macrophages; Mice; Peritoneal Cavity; Phosphoproteins; Protein Kinase C; SRS-A; Tetradecanoylphorbol Acetate | 1990 |
Regulation of arachidonic acid release in mouse peritoneal macrophages. The role of extracellular calcium and protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascitic Fluid; Calcimycin; Calcium; Concanavalin A; Inositol Phosphates; Macrophages; Mice; Protein Kinase C; Secretory Rate; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Involvement of membrane charges in constituting the active form of NADPH oxidase in guinea pig polymorphonuclear leukocytes.
Topics: Amines; Animals; Arachidonic Acid; Arachidonic Acids; Cell Fractionation; Cell Membrane; Enzyme Activation; Glutaral; Guinea Pigs; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Tetradecanoylphorbol Acetate | 1990 |
Involvement of a guanine-nucleotide-binding protein-mediated mechanism in the enhancement of arachidonic acid liberation by phorbol 12-myristate 13-acetate and Ca2+ in saponin-permeabilized platelets.
Topics: Alkaloids; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cell Membrane Permeability; Chlorides; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Pertussis Toxin; Protein Kinase C; Rabbits; Saponins; Sodium Fluoride; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1990 |
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1990 |
Mechanism of 12-O-tetradecanoylphorbol-13-acetate enhanced metabolism of arachidonic acid in dog urothelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprostone; Dogs; Eicosanoids; Epidermal Growth Factor; Epithelium; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Tritium; Urinary Bladder | 1990 |
Role of protein kinase C in the regulation of phospholipase A2 activity in human platelets.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Cell Membrane; Humans; Molecular Weight; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Nitroprusside inhibits platelet function primarily by inhibiting Ca2+ mobilization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Calcium; Collagen; Ferricyanides; Humans; In Vitro Techniques; Nitroprusside; Phosphatidic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Effects of the calpain inhibitor E64-d on platelet activation responses.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; Calpain; Collagen; Humans; In Vitro Techniques; Leucine; Phosphatidic Acids; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Involvement of external calcium in the release of arachidonic acid by mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Extracellular Space; Female; In Vitro Techniques; Macrophages; Mice; Peritoneal Cavity; Tetradecanoylphorbol Acetate | 1990 |
FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigen-Antibody Complex; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Carrageenan; Cyclooxygenase Inhibitors; Eicosanoids; Female; Guinea Pigs; Humans; In Vitro Techniques; Inflammation; Lipoxygenase Inhibitors; Mice; Neutrophils; Prostaglandin D2; Pyrazoles; Rabbits; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1990 |
Biochemical and pharmacological properties of a new topical anti-inflammatory compound, 9-phenylnonanohydroxamic acid (BMY 30094).
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 12-Lipoxygenase; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Carrageenan; Chromatography, High Pressure Liquid; Eicosanoids; Exudates and Transudates; Female; Hydroxamic Acids; Inflammation; Male; Mice; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Ethanol inhibits thrombin-induced secretion by human platelets at a site distinct from phospholipase C or protein kinase C.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Enzyme Activation; Ethanol; Humans; Indomethacin; Inositol Phosphates; Ionomycin; Microscopy, Electron; Phosphatidic Acids; Platelet Activation; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1990 |
Differential effects of various skin tumor-promoting agents on prostaglandin E2 release from primary cultures of mouse epidermal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cells, Cultured; Dinoprostone; Enzyme Activation; Macrophages; Mice; Protein Kinase C; Radioimmunoassay; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1990 |
Mechanism of N-formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-induced arachidonic acid release in guinea pig alveolar macrophages: involvement of a GTP-binding protein and role of protein kinase A and protein kinase C.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Down-Regulation; GTP-Binding Proteins; Guinea Pigs; Isoquinolines; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pertussis Toxin; Platelet Activating Factor; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Alveoli; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Diglycerides; Glucose; Glycerol; Inositol; Insecticides; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Phosphates; Piperazines; Protein Kinase Inhibitors; Pyrethrins; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Regulation of eicosanoid biosynthesis by phorbol ester in Madin Darby canine kidney cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Eicosanoids; Kidney; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Translocation of the 46 kDa protein(s) in response to activation of NADPH oxidase in guinea pig polymorphonuclear leukocytes.
Topics: Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Blood Proteins; Cell Membrane; Cell-Free System; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Guinea Pigs; In Vitro Techniques; Molecular Weight; NADH, NADPH Oxidoreductases; Neutrophils; Peptide Mapping; Phosphorylation; Serine Endopeptidases; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1990 |
Influence of extracellular calcium on the metabolism of arachidonic acid in alveolar macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Egtazic Acid; Indomethacin; Macrophages; Phospholipases A; Phospholipases A2; Pulmonary Alveoli; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Dual effects of staurosporine on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Kinetics; Macrophages; Peritoneal Cavity; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Differential dependence on protein kinase C of arachidonic acid metabolism stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Eicosanoids; Female; Hydrogen Peroxide; Macrophages; Phorbol Esters; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Induction of gene expression by IL-1 in NIH 3T3 cells. Possible requirement of protein kinase C activity and independence from arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cyclooxygenase Inhibitors; Dinoprostone; Gene Expression; Interleukin-1; Lipoxygenase Inhibitors; Mice; Protein Kinase C; Pyrimidinones; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1990 |
Differential changes in lipid metabolism of myeloid and lymphoid cell lines induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Arachidonic Acid; Arachidonic Acids; Cell Line; Glycerides; Glycerol; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Lipid Metabolism; Lymphoma, Large B-Cell, Diffuse; Tetradecanoylphorbol Acetate | 1990 |
Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol.
Topics: Aging; Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; In Vitro Techniques; Ionomycin; Islets of Langerhans; Kinetics; Male; Myristic Acid; Myristic Acids; Phospholipase D; Phospholipids; Rats; Rats, Inbred Strains; Stearic Acids; Tetradecanoylphorbol Acetate | 1990 |
The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Cytotoxicity, Immunologic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Indomethacin; Interferon-gamma; Leukocytes, Mononuclear; Leukotrienes; Lipoxygenase Inhibitors; Masoprocol; Middle Aged; Neoplasms; Oxygenases; Tetradecanoylphorbol Acetate | 1990 |
The effect of ultraviolet radiation and melanocyte-stimulating hormone on tyrosinase activity in epidermal melanocytes of the mouse.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Cells; Female; Indomethacin; Male; Melanocyte-Stimulating Hormones; Melanocytes; Mice; Monophenol Monooxygenase; Protein Kinase C; Tetradecanoylphorbol Acetate; Theophylline; Ultraviolet Rays | 1990 |
5-Hydroxyeicosatetraenoic acid and phorbol ester stimulate prolactin release from rat anterior pituitary cells by different mechanisms.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Drug Interactions; Female; Hydroxyeicosatetraenoic Acids; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Radioimmunoassay; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Modes of inhibitory action of 4 beta-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane Permeability; Chlorides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Rabbits; Serotonin; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Diacylglycerol Kinase; Humans; In Vitro Techniques; Isoquinolines; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Piperazines; Protein Kinase C; Quinacrine; Tetracaine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester promotes a sustained down-regulation of endothelin receptors and cellular responses to endothelin in human vascular smooth muscle cells.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Down-Regulation; Endothelins; Endothelium, Vascular; Humans; Inositol; Inositol Phosphates; Kinetics; Muscle, Smooth, Vascular; Omentum; Peptides; Receptors, Cell Surface; Receptors, Endothelin; Tetradecanoylphorbol Acetate | 1990 |
Histamine-stimulated and GTP-binding proteins-mediated phospholipase A2 activation in rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Histamine; Humans; Immune Sera; Kinetics; Norepinephrine; Pertussis Toxin; Phospholipases; Phospholipases A; Phospholipases A2; Rabbits; Receptors, Histamine H1; Serotonin; Tetradecanoylphorbol Acetate; Thionucleotides; Thrombin; Virulence Factors, Bordetella | 1990 |
Action sites of antiallergic drugs on human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Histamine Antagonists; Humans; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Reversible drug effects on the metabolic activation of polymorphonuclear leukocytes.
Topics: Amines; Animals; Arachidonic Acid; Arachidonic Acids; Benzenesulfonates; Chlorpromazine; Guinea Pigs; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phthalazines; Pyridazines; Spectrophotometry; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Cyclic AMP; Dinoprostone; Endothelins; Glomerular Mesangium; Ionomycin; Peptides; Rats; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1990 |
Alpha 1-adrenergic receptor mediates arachidonic acid release in spinal cord neurons independent of inositol phospholipid turnover.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Extracellular Space; Inositol Phosphates; Neurons; Norepinephrine; Pertussis Toxin; Phosphatidylinositols; Receptors, Adrenergic, alpha; Spinal Cord; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Inhibition of active oxygen generation in guinea-pig neutrophils by biscoclaurine alkaloids.
Topics: Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Benzylisoquinolines; Free Radicals; Guinea Pigs; Luminescent Measurements; Luminol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Pharmacological modification of mechanical and electrical responses of frog heart to thrombin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Barium; Barium Compounds; Calcium Channels; Chlorides; Electrophysiology; Enzyme Activation; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Piperazines; Protein Kinase C; Rana esculenta; Tetradecanoylphorbol Acetate; Thrombin; Vasoconstriction | 1990 |
"Autoregulation" of human neutrophil activation in vitro: regulation of phorbol myristate acetate-induced neutrophil activation by cell density.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Count; Cell Membrane; Flow Cytometry; Homeostasis; Humans; Hydrogen Peroxide; Inflammation; Microscopy, Electron; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Evidence for a functional cytoplasmic domain of phagocyte oxidase cytochrome b558.
Topics: Amino Acid Sequence; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cytochrome b Group; Cytosol; Enzyme Activation; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oligopeptides; Phosphorylation; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Effect of inhibin on activators of protein kinase-C and calcium-mobilizing agents which stimulate secretion of gonadotropins in vitro: implication of a postgonadotropin-releasing hormone receptor effect of inhibin on gonadotropin release.
Topics: Adrenocorticotropic Hormone; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Diterpenes; Enzyme Activation; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Inhibins; Luteinizing Hormone; Male; Melitten; Pituitary Gland, Anterior; Potassium; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, LHRH; Terpenes; Tetradecanoylphorbol Acetate | 1990 |
Calcitonin decreases thyrotropin-releasing hormone-stimulated prolactin release through a mechanism that involves inhibition of inositol phosphate production.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Calcitonin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Female; Inositol Phosphates; Marine Toxins; Neurotensin; Oxocins; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1990 |
Peptides generated from C-reactive protein by a neutrophil membrane protease. Amino acid sequence and effects of peptides on neutrophil oxidative metabolism and chemotaxis.
Topics: Amino Acid Sequence; Arachidonic Acid; Arachidonic Acids; C-Reactive Protein; Calcium; Cell Degranulation; Cell Membrane; Chemotaxis, Leukocyte; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Luminescent Measurements; Molecular Sequence Data; Neutrophils; Oxygen; Peptide Fragments; Phagocytosis; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Alpha-1 adrenergic receptor mediates the release of arachidonic acid in spinal cord neurons independent of phosphatidylinositol-specific phospholipase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; GTP-Binding Proteins; Membrane Lipids; Nervous System; Neurons; Norepinephrine; Phospholipases A; Receptors, Adrenergic, alpha; Second Messenger Systems; Spinal Cord; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1990 |
Calcium ionophore but not phorbol ester promotes eicosanoids release by proliferating interleukin-3-dependent bone marrow cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bone Marrow Cells; Calcimycin; Calcium; Cell Division; Clone Cells; Dinoprostone; DNA; Female; Hematopoietic Stem Cells; Interleukin-3; Leukotriene B4; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred CBA; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Regulation of platelet-activating factor receptor and PAF receptor-mediated arachidonic acid release by protein kinase C activation in rat Kupffer cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Dimethyl Sulfoxide; Down-Regulation; Enzyme Activation; Kinetics; Kupffer Cells; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate | 1990 |
Human cytomegalovirus. Stimulation of [3H] release from [3H]-arachidonic acid prelabelled cells.
Topics: Antigens, Viral; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Membrane; Cells, Cultured; Cycloheximide; Cytomegalovirus; Deoxyadenosines; Fibroblasts; Gene Expression; Humans; Immunologic Techniques; Tetradecanoylphorbol Acetate; Tritium; Ultraviolet Rays; Virion | 1990 |
Respiratory burst of rabbit peritoneal neutrophils. Transition from an NADPH diaphorase activity to an .O2(-)-generating oxidase activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Cell Membrane; Cross-Linking Reagents; Cytochrome c Group; Cytosol; Enzyme Activation; Ferricyanides; Glutaral; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Nitroblue Tetrazolium; Oxidation-Reduction; Peritoneal Cavity; Rabbits; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Effect of the spin trap 5,5 dimethyl-1-pyrroline-N-oxide (DMPO) on human neutrophil function: novel inhibition of neutrophil stimulus-response coupling?
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Concanavalin A; Cyclic N-Oxides; Cytochrome c Group; Cytoplasmic Granules; Humans; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Spin Labels; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1990 |
Differential regulation of 5-lipoxygenase and cyclo-oxygenase pathways of arachidonate metabolism in rat peritoneal leukocytes.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Female; In Vitro Techniques; Leukocytes; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1990 |
Hydrocortisone inhibits phorbol ester stimulated release of histamine and arachidonic acid from rat mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Histamine Release; Hydrocortisone; Mast Cells; Phorbols; Rats; Somatostatin; Tetradecanoylphorbol Acetate | 1985 |
1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcimycin; Carbachol; Dibutyryl Cyclic GMP; Diglycerides; Glycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase C; Sincalide; Tetradecanoylphorbol Acetate; Tetragastrin | 1986 |
The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on phospholipid metabolism of human epidermal keratinocytes in culture.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cells, Cultured; Choline; Enzyme Activation; Epidermal Cells; Epidermis; Fetal Blood; Humans; Hydrocortisone; Keratins; Phospholipases; Phospholipids; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tritium | 1986 |
Increased prostaglandin synthesis by low calcium-regulated keratinocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Epidermal Cells; Epidermis; Keratins; Prostaglandins; Tetradecanoylphorbol Acetate | 1986 |
Synergism between thapsigargin and the phorbol ester 12-O-tetradecanoylphorbol 13-acetate on the release of [14C]arachidonic acid and histamine from rat peritoneal mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Carbon Radioisotopes; Drug Synergism; Histamine Release; In Vitro Techniques; Male; Mast Cells; Plant Extracts; Prostaglandin D2; Prostaglandins D; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin | 1987 |
Release of arachidonic acid metabolites by human monocytes or lymphocytes: effect of treatment with interferon on stimulation by phorbol ester or calcium ionophore.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Humans; Hydroxyeicosatetraenoic Acids; Interferons; Leukotriene B4; Lymphocytes; Monocytes; Prostaglandins; Recombinant Proteins; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1987 |
Effect of alpha-fetoprotein and indomethacin on arachidonic acid metabolism in P388D1 macrophages: role of leukotrienes.
Topics: 6-Ketoprostaglandin F1 alpha; alpha-Fetoproteins; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Dinoprostone; Drug Interactions; Indomethacin; Macrophages; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1987 |
Bryostatin 1, an activator of protein kinase C, mimics as well as inhibits biological effects of the phorbol ester TPA in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Arachidonic Acids; Bryostatins; Calcium; Cell Line; Cells, Cultured; Dinoprostone; DNA Replication; Enzyme Activation; Epidermis; Female; Keratins; Lactones; Macrolides; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Prostaglandins E; Protein Kinase C; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transglutaminases | 1988 |
Dantrolene-induced inhibition of insulin release. A mechanism independent of effects on calcium fluxes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Dantrolene; Fatty Acids; Hydroxymercuribenzoates; Insulin; Insulin Secretion; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trifluoperazine; Type C Phospholipases | 1988 |
Stimulation of human amnion prostaglandin E2 production by activators of protein kinase-C.
Topics: Amnion; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Cycloheximide; Dactinomycin; Diglycerides; Dinoprostone; Drug Synergism; Enzyme Activation; Female; Humans; Pregnancy; Protein Biosynthesis; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate | 1988 |
Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Brain; Bucladesine; Colforsin; Cricetinae; Diglycerides; Enzyme Activation; Glycerides; Hybrid Cells; Inositol Phosphates; Kinetics; Mice; Molecular Weight; Neuroblastoma; Phosphates; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bucladesine; Calcimycin; Cell Differentiation; Cell Line; Cytosol; Dimethyl Sulfoxide; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hexachlorocyclohexane; Humans; Kinetics; Leukemia, Promyelocytic, Acute; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Superoxides; Tetradecanoylphorbol Acetate; Thionucleotides | 1989 |
Amplifying effects of several vasoconstrictor agents of alpha 1-adrenoceptor-mediated contraction of isolated thoracic aortae of the guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Azepines; Dose-Response Relationship, Drug; Endothelium; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Ouabain; Phenylephrine; Receptors, Adrenergic, alpha; Serotonin; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1989 |
A role for protein kinase C-mediated phosphorylation in the mobilization of arachidonic acid in mouse macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Electrophoresis, Polyacrylamide Gel; Female; Lipopolysaccharides; Macrophages; Mice; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Zymosan | 1989 |
Weak inhibition of protein kinase C coupled with various non-specific effects make sphingosine an unsuitable tool in platelet signal transduction studies.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Calcium; Ethers; Humans; In Vitro Techniques; Ionomycin; Kinetics; Male; Molecular Weight; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Serotonin; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester, 1,2-diacylglycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Acylglycerophosphocholine O-Acyltransferase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Coenzyme A Ligases; Collagen; Diglycerides; Enzyme Activation; Glycerides; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1989 |
Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Drug Interactions; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; Hydroxyeicosatetraenoic Acids; Leukotrienes; Lipid Peroxides; Lipoxygenase; Progesterone; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1989 |
A phospholipase A2 hydrolyzing arachidonoyl-phospholipids in mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Cytosol; Glycerol; Hydrogen-Ion Concentration; Macrophages; Masoprocol; Mice; Peritoneal Cavity; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Quercetin; Tetradecanoylphorbol Acetate | 1989 |
Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester.
Topics: Arachidonic Acid; Arachidonic Acids; Dexamethasone; DNA-Binding Proteins; Gene Expression Regulation; Humans; Leukemia, Promyelocytic, Acute; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1989 |
Arachidonic acid release in rabbit neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activating Factor; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1989 |
Differential role of protein kinase C in the action of luteinizing hormone-releasing hormone on hormone production in rat ovarian cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprost; Dinoprostone; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Granulosa Cells; Melitten; Ovary; Progesterone; Prostaglandins; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Modulation by phorbol 12-myristate 13-acetate of arachidonic acid release from rat basophilic leukemia cells stimulated with A23187.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Drug Synergism; Leukemia, Basophilic, Acute; Phospholipases; Phospholipids; Prostaglandin D2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Differential effects of phorbol 12-myristate 13-acetate on GTP gamma S-induced diacylglycerol formation and arachidonic acid liberation in saponin-permeabilized rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Diglycerides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Lipids; Permeability; Phospholipases A; Phospholipases A2; Rabbits; Saponins; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1989 |
Effect of a 5-lipoxygenase (5-LO)/cyclooxygenase (CO) inhibitor, WY-47, 288, on cutaneous models of inflammation.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Disease Models, Animal; Ear; Erythema; Female; Guinea Pigs; Inflammation; Lipoxygenase Inhibitors; Mice; Naphthalenes; Quinolines; Radiation Injuries; Salicylates; Skin; Skin Diseases; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1989 |
Evidence that phorbol diester-sensitive protein kinase-C(s) may not be directly involved in secretagogue-stimulated prolactin release and arachidonate liberation.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cells, Cultured; Female; Kinetics; Marine Toxins; Neurotensin; Oxocins; Phorbol 12,13-Dibutyrate; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1989 |
Stimulus-specific production of cyclooxygenase and lipoxygenase metabolites of arachidonic acid by bovine alveolar macrophages.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Calcimycin; Cattle; Cells, Cultured; Macrophages; Male; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Tetradecanoylphorbol Acetate; Zymosan | 1989 |
Regulation of dog urothelial cell arachidonic acid release and prostaglandin E2 synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cell Division; Cells, Cultured; Culture Media; Cycloheximide; Dinoprostone; Dogs; Epithelium; Kinetics; Microscopy, Electron; Tetradecanoylphorbol Acetate; Urinary Bladder | 1989 |
Enhancement of arachidonic acid liberation by protein kinase C activator is partially dependent on extracellular Na+ in rabbit platelets.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Diglycerides; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Hydrogen-Ion Concentration; Intracellular Membranes; Protein Kinase C; Rabbits; Sodium; Tetradecanoylphorbol Acetate | 1989 |
Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release, and arachidonic acid production by oncogenic ras is a consequence of protein kinase C activation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Enzyme Activation; Glycerides; Hydrolysis; Insulin; Kinetics; Membrane Proteins; Mice; Phosphatidylcholines; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Tetradecanoylphorbol Acetate | 1989 |
Phospholipase activation and arachidonic acid release in cultured intestinal epithelial cells (INT 407).
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Diglycerides; Enzyme Activation; Epithelial Cells; Epithelium; Humans; Intestinal Mucosa; Phospholipases; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1989 |
Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cells, Cultured; Dinoprostone; Ethers, Cyclic; Ionophores; Kinetics; Macrophages; Marine Toxins; Okadaic Acid; Pyrans; Rats; Tetradecanoylphorbol Acetate | 1989 |
The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Enzyme Activation; Glucuronidase; GTP-Binding Proteins; Humans; Inositol Phosphates; Neutrophils; Pertussis Toxin; Phospholipases; Phospholipases A; Phospholipases A2; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Purinergic; Ribonucleotides; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Decreased prostaglandin production by cholesterol-rich macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis; Cholesterol; Dinoprostone; Epoprostenol; Fatty Acids; Foam Cells; In Vitro Techniques; Macrophages; Male; Mice; Phospholipids; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Tetradecanoylphorbol Acetate | 1989 |
2-(2-hydroxy-4-methylphenyl)aminothiazole hydrochloride as a dual inhibitor of cyclooxygenase/lipoxygenase and a free radical scavenger. 1st communication: in vitro studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cells, Cultured; Chromosome Aberrations; Cyclooxygenase Inhibitors; Free Radicals; Humans; In Vitro Techniques; Leukotrienes; Lipid Peroxidation; Lipoxygenase Inhibitors; Oxygen Consumption; Rabbits; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thiazoles | 1989 |
Phorbol myristate enhanced specific incorporation of arachidonic acid into phospholipids through lysophospholipid acyltransferase in cultured smooth muscle cells.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acetyltransferases; Acyl Coenzyme A; Acyltransferases; Analysis of Variance; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Enzyme Activation; Fatty Acids, Unsaturated; Lipopolysaccharides; Lysophosphatidylcholines; Muscle, Smooth; Phosphatidylcholines; Phospholipases; Phospholipids; Rabbits; Substrate Specificity; Tetradecanoylphorbol Acetate | 1989 |
Requirement and role of arachidonic acid in the differentiation of pre-adipose cells.
Topics: Adipose Tissue; Animals; Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Line; Cyclic AMP; Cyclic GMP; Ethers; Inositol; Ionomycin; Mice; Mice, Inbred C57BL; Mitosis; Phorbol 12,13-Dibutyrate; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 1989 |
Virus-induced enhancement of arachidonate metabolism by bovine alveolar macrophages in vitro.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cattle; Macrophages; Male; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Phospholipids; Pulmonary Alveoli; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1989 |
Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Endothelins; Endothelium, Vascular; Hydrolysis; Inositol Phosphates; Muscle, Smooth, Vascular; Peptides; Pertussis Toxin; Phosphatidylinositols; Phospholipases A; Rabbits; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Protease-modulation of neutrophil superoxide response.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Cathepsin G; Cathepsins; Chymotrypsin; Drug Combinations; Humans; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pancreatic Elastase; Peptide Hydrolases; Serine Endopeptidases; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Muscarinic receptor activation of phosphatidylcholine hydrolysis. Relationship to phosphoinositide hydrolysis and diacylglycerol metabolism.
Topics: Arachidonic Acid; Arachidonic Acids; Astrocytoma; Calcium; Carbachol; Cell Line; Choline; Diglycerides; Glycerides; Humans; Hydrolysis; Intracellular Fluid; Myristic Acid; Myristic Acids; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Protein Kinase C; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Tritium | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Leukotriene B4 metabolism in neutrophils of patients with chronic granulomatous disease: phorbol myristate acetate decreases endogenous leukotriene B4 via NADPH oxidase-dependent mechanism.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Granulomatous Disease, Chronic; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; SRS-A; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Cytoplasmic pH dependency of Na+/H+ exchange in human platelets activated with thrombin, arachidonic acid, A23187 and TPA.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Carrier Proteins; Cytoplasm; Humans; Hydrogen; Hydrogen-Ion Concentration; Nigericin; Sodium; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Thrombin | 1989 |
Arachidonic acid potentiates superoxide anion radical production by murine peritoneal macrophages stimulated with tumor promoters.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cells, Cultured; Diterpenes; Female; Kinetics; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phorbol Esters; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Different pathways initiating arachidonic acid (AA) release/thromboxane (TxA2) formation in human platelets--studies with fluoride and phorbol ester.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bucladesine; Calcium; Humans; In Vitro Techniques; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1989 |
A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Calmodulin; Carbachol; Cell Membrane; Cyclic AMP; Cytosol; Gallic Acid; Gene Expression; Genes; Inositol Phosphates; Kinetics; L Cells; Mice; Models, Biological; Phosphatidylinositols; Protein Kinase C; Receptors, Muscarinic; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 1989 |
Superoxide generation is inhibited by phospholipase A2 inhibitors. Role for phospholipase A2 in the activation of the NADPH oxidase.
Topics: Acetophenones; Amino Alcohols; Arachidonic Acid; Arachidonic Acids; Cell-Free System; Enzyme Activation; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Quinacrine; Sodium Dodecyl Sulfate; Superoxides; Tetradecanoylphorbol Acetate | 1989 |
Effects of ciclosporin and protein synthesis inhibitors on cutaneous inflammation in mouse skin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Cycloheximide; Cyclosporins; Dactinomycin; Dermatitis; Female; Hypersensitivity, Delayed; Mice; Mice, Inbred Strains; Neutrophils; Oxazolone; Peroxidase; Protein Synthesis Inhibitors; Skin; Tetradecanoylphorbol Acetate | 1989 |
Topical cyclosporine A inhibits the phorbol ester induced hyperplastic inflammatory response but not protein kinase C activation in mouse epidermis.
Topics: Administration, Topical; Animals; Arachidonic Acid; Arachidonic Acids; Cyclosporine; Cyclosporins; Dermatitis; Dinoprostone; Enzyme Activation; Epidermis; Hyperplasia; Interleukins; Mice; Mice, Hairless; Ornithine Decarboxylase; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transglutaminases | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Ethoxyquin; Flavonoids; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Quercetin; Rats; Rats, Inbred F344; Tetradecanoylphorbol Acetate | 1989 |
Modulation of human neutrophil LTA hydrolase activity by phorbol myristate acetate.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Interactions; Epoxide Hydrolases; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Tetradecanoylphorbol Acetate | 1987 |
Stimulation of phospholipid hydrolysis and arachidonic acid mobilization in human uterine decidua cells by phorbol ester.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Choline; Decidua; Female; Humans; Hydrolysis; Oxytocin; Phosphatidylinositols; Phospholipids; Pregnancy; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Vasopressins | 1987 |
Differential effects of the diacylglycerol kinase inhibitor R59022 on thrombin versus collagen-induced human platelet secretion.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Collagen; Diacylglycerol Kinase; Diglycerides; Dose-Response Relationship, Drug; Ethers; Glycerides; Humans; Ionomycin; Phosphoproteins; Phosphotransferases; Platelet Aggregation; Pyrimidinones; Serotonin; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1988 |
The interaction of ethanol and exogenous arachidonic acid in the generation of extracellular messengers by mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Ethanol; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Macrophage Activation; Macrophages; Mice; Peritoneal Cavity; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Separation; Concanavalin A; Cytoplasm; Digitonin; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Platelet Activating Factor; Protons; Sodium; Tetradecanoylphorbol Acetate | 1988 |
Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Colforsin; Cyclic AMP; Mice; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogenes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Activation by saturated and monounsaturated fatty acids of the O2- -generating system in a cell-free preparation from neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane; Cell-Free System; Cytosol; Fatty Acids; Fatty Acids, Unsaturated; Kinetics; Lauric Acids; Lipoxygenase Inhibitors; Masoprocol; NADP; Neutrophils; Oleic Acid; Oleic Acids; Oxygen Consumption; Pyrazoles; Superoxides; Swine; Tetradecanoylphorbol Acetate | 1988 |
Reactive oxygen in the tumor promotion stage of skin carcinogenesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cocarcinogenesis; Epidermis; Female; Luminescent Measurements; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Oxygen; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Calcium; Carbachol; Cell Division; Cloning, Molecular; Cyclic AMP; Enzyme Activation; Genes; Kinetics; L Cells; Mice; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Arachidonic acid release is closely related to the Fc gamma receptor-mediated superoxide generation in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Glucose; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoquinolines; Macrophages; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Quinones; Receptors, Fc; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Stimulation of arachidonic acid metabolism by different types of tumor promoters.
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Line; Cnidarian Venoms; Drug Synergism; Epidermal Growth Factor; Liver; Peptides; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
A combination of palytoxin with 1-oleoyl-2-acetyl-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combinations of 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters with OAG do not.
Topics: 6-Ketoprostaglandin F1 alpha; Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Line; Cnidarian Venoms; Diglycerides; Dinoprost; Drug Synergism; Glycerides; Insulin; Interleukin-1; Kinetics; Liver; Phorbols; Prostaglandins F; Rats; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1986 |
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion].
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cnidarian Venoms; Enzyme Activation; Humans; Lyngbya Toxins; Mice; Neoplasms, Experimental; Phorbols; Plant Extracts; Protein Kinase C; Receptors, Cell Surface; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thapsigargin | 1986 |
Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation o
Topics: Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Calcimycin; Calcium; Diglycerides; Lysophosphatidylcholines; Male; Norepinephrine; Organ Culture Techniques; Ouabain; Ovariectomy; Phenylephrine; Phospholipases; Phospholipases A; Phospholipases A2; Pineal Gland; Potassium; Protein Kinase C; Quinacrine; Rats; Tetradecanoylphorbol Acetate | 1987 |
Prostaglandin production by human promyelocytic leukemia (HL-60) cells.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dimethyl Sulfoxide; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Prostaglandins; Tetradecanoylphorbol Acetate; Transglutaminases | 1988 |
Mechanism of TPA stimulation of arachidonic acid metabolism in rat liver C-9 cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Kinetics; Liver; Phorbols; Rats; Tetradecanoylphorbol Acetate | 1985 |
Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Arachidonic Acids; beta-Thromboglobulin; Blood Platelets; Calcium; Drug Synergism; Humans; Male; Prostaglandin Endoperoxides, Synthetic; Serotonin; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2 | 1986 |
Desensitization of macrophage oxygen metabolism on immobilized ligands: different effect of immunoglobulin G and complement.
Topics: Animals; Antigen-Antibody Complex; Arachidonic Acid; Arachidonic Acids; Cell Adhesion; Cells, Cultured; Complement C3; Culture Techniques; Female; Immunoglobulin G; Macrophage Activation; Macrophages; Male; Mice; Oxygen; Phagocytosis; Receptors, Fc; Receptors, IgG; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
The activation of human fibroblast prostaglandin E production by interleukin 1.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Line; Cycloheximide; Dactinomycin; Ethers; Fibroblasts; Humans; Indomethacin; Interleukin-1; Ionomycin; Prostaglandins E; Receptors, Immunologic; Receptors, Interleukin-1; Tetradecanoylphorbol Acetate; Time Factors; Trypsin | 1987 |
Arachidonate stimulates prolactin release in vitro: a role for the fatty acid and its metabolites as intracellular regulator(s) in mammotrophs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Bucladesine; Catechols; Cells, Cultured; Female; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Oleic Acid; Oleic Acids; Phospholipases A; Phospholipases A2; Pituitary Gland; Pituitary Gland, Anterior; Prolactin; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Stearic Acids; Tetradecanoylphorbol Acetate | 1985 |
Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Hydroxides; Hydroxyl Radical; Lipoxygenase Inhibitors; Mannitol; Mice; Phorbols; Skin Neoplasms; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Stimulus interactions in release of superoxide anion (O2-) from human neutrophils. Further evidence for multiple pathways of activation.
Topics: Adult; Arachidonic Acid; Arachidonic Acids; Complement C5; Complement C5a; Concanavalin A; Drug Synergism; Egtazic Acid; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Stimulation, Chemical; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
Phorbol 12-myristate, 13-acetate potentiates the action of the calcium ionophore in stimulating arachidonic acid release and production of phosphatidic acid in rabbit neutrophils.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Neutrophils; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Rabbits; Sodium Chloride; Tetradecanoylphorbol Acetate | 1985 |
Effects of epidermal growth factor, phorbol myristate acetate, and arachidonic acid on choriogonadotropin secretion by cultured human choriocarcinoma cells.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Catechols; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Indomethacin; Masoprocol; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Pregnancy; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 1985 |
Role of enhanced inositol phospholipid metabolism in neutrophil activation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Proteins; Calcimycin; Calcium; Guinea Pigs; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylation; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Free Radicals; Lipoxygenase Inhibitors; Luminescent Measurements; Mice; Neutrophils; Phorbols; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Effects of chemotactic factors and other agents on the amounts of actin and a 65,000-mol-wt protein associated with the cytoskeleton of rabbit and human neutrophils.
Topics: Actins; Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cytoskeleton; Glucose; Humans; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Tetradecanoylphorbol Acetate; Urea; Water-Electrolyte Balance | 1985 |
Role of hydroxyl radical in neutrophil-mediated cytotoxicity.
Topics: Arachidonic Acid; Arachidonic Acids; Catechols; Cytotoxicity, Immunologic; Humans; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Masoprocol; Neoplasms; Neutrophils; Tetradecanoylphorbol Acetate | 1985 |
Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Auranofin; Aurothioglucose; Cells, Cultured; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Lipoxygenase Inhibitors; Lymphokines; Macrophage Activation; Macrophage-Activating Factors; Macrophages; Male; Mice; Neoplasms, Experimental; Phagocytosis; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1985 |
Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.
Topics: Adenylate Cyclase Toxin; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Dose-Response Relationship, Drug; Guinea Pigs; Inositol Phosphates; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositols; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases; Virulence Factors, Bordetella | 1985 |
Activation of human granulocytes by arachidonic acid: its use and limitations for investigating granulocyte functions.
Topics: Arachidonic Acid; Arachidonic Acids; Concanavalin A; Cytoplasm; Egtazic Acid; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potentials; Muramidase; Neutrophils; Oxygen Consumption; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Treatment of lymphocyte cultures with a hypoxanthine-xanthine oxidase system induces the formation of transferable clastogenic material.
Topics: Arachidonic Acid; Arachidonic Acids; Catalase; Cells, Cultured; Chromosome Aberrations; DNA; Free Radicals; Glutathione Peroxidase; Humans; Hypoxanthine; Hypoxanthines; Lymphocytes; Mutagens; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate; Thiobarbiturates; Xanthine Oxidase | 1985 |
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cell Membrane; Cell Survival; Cytochrome c Group; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Differential effects of mepacrine, chloroquine and hydroxychloroquine on superoxide anion generation, phospholipid methylation and arachidonic acid release by human blood monocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Survival; Chloroquine; Fluorides; Humans; Hydroxychloroquine; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Phospholipids; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Modulation by phorbol myristate acetate of arachidonic acid release and leukotriene synthesis by human polymorphonuclear leukocytes stimulated with A23187.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Human growth hormone-stimulated mitogenesis of Nb2 node lymphoma cells is not mediated by an immediate acceleration of phosphoinositide metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Line; Growth Hormone; Humans; Inositol; Lymphoma; Phosphatidylinositols; Rats; Tetradecanoylphorbol Acetate | 1986 |
Activation of neutrophil superoxide production by concanavalin A can occur at low levels of intracellular ionized calcium.
Topics: Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Calcium; Concanavalin A; Humans; Intracellular Fluid; Methylmannosides; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Membrane; Cell-Free System; Cytosol; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Neutrophils; Platelet Activating Factor; Protamine Kinase; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Solubility; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1987 |
The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites.
Topics: Arachidonic Acid; Arachidonic Acids; Humans; Immunoglobulin G; Leukotriene B4; Ligands; Linoleic Acid; Linoleic Acids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Drug; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
Phorbol myristate acetate and the calcium ionophore A23187 synergistically induce release of LTB4 by human neutrophils: involvement of protein kinase C activation in regulation of the 5-lipoxygenase pathway.
Topics: Adult; Arachidonate 5-Lipoxygenase; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Drug Synergism; Enzyme Activation; Humans; Leukotriene B4; Membrane Proteins; Neutrophils; Protein Kinase C; Secretory Rate; Tetradecanoylphorbol Acetate | 1987 |
Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Guinea Pigs; Isoquinolines; Macrophages; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Charge-dependent regulation of NADPH oxidase activity in guinea-pig polymorphonuclear leukocytes.
Topics: Amines; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Membrane; Electrochemistry; Enzyme Activation; Guinea Pigs; Hydrocarbons; Intracellular Membranes; Male; Myristic Acid; Myristic Acids; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Coordinate actions of arachidonic acid and protein kinase C in gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Cells, Cultured; Drug Synergism; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Masoprocol; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Retinaldehyde; Tetradecanoylphorbol Acetate | 1986 |
Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by 1H-n.m.r. and GC-MS spectroscopy.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Magnetic Resonance Spectroscopy; Mice; Phorbol Esters; Skin; Tetradecanoylphorbol Acetate | 1986 |
Role of circulating granulocytes in sheep lung injury produced by phorbol myristate acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Blood Proteins; Cardiac Output; Granulocytes; Leukopenia; Lung; Lung Injury; Lymph; Oxygen Consumption; Phorbols; Pulmonary Circulation; Pulmonary Edema; Respiratory Distress Syndrome; Sheep; Tetradecanoylphorbol Acetate; Vascular Resistance | 1986 |
A defect of platelet release reaction in a patient with SLE: impaired platelet aggregation induced by phorbol ester with a normal phosphorylation of 40K protein.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Blood Proteins; Calcimycin; Collagen; Diglycerides; Epinephrine; Female; Humans; Lupus Erythematosus, Systemic; Phorbols; Phosphorylation; Platelet Activating Factor; Platelet Aggregation; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin?
Topics: Actins; Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cytoskeletal Proteins; Cytoskeleton; Fluorescent Dyes; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
The effect of macrophage development on the release of reactive oxygen intermediates and lipid oxidation products, and their ability to induce oxidative DNA damage in mammalian cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; BCG Vaccine; Cells, Cultured; DNA; Hydrogen Peroxide; Macrophage Activation; Macrophages; Mice; Oxidation-Reduction; Tetradecanoylphorbol Acetate; Thymine | 1986 |
Evidence for a catalytic role of phospholipase A in phorbol diester- and zymosan-induced mobilization of arachidonic acid in mouse peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascitic Fluid; Chlorpromazine; Macrophages; Mice; Phloretin; Phorbol Esters; Phosphatidylinositols; Phospholipases; Phospholipases A; Tetradecanoylphorbol Acetate; Type C Phospholipases; Umbelliferones; Zymosan | 1986 |
The effect of tetradecanoylphorbol acetate on calcium-ion mobilization, protein phosphorylation and cytoskeletal assembly induced by thrombin or arachidonate.
Topics: Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cytoskeleton; Ethers; Humans; Ionomycin; Myosins; Phorbols; Phosphorylation; Platelet Aggregation; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Erythrocytes; Erythropoiesis; Granulocytes; Hematopoiesis; Humans; Indomethacin; Lipoxygenase; Macrophages; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Tetradecanoylphorbol Acetate | 1986 |
A possible role for protein phosphorylation in the activation of the respiratory burst in human neutrophils. Evidence from studies with cells from patients with chronic granulomatous disease.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Fractionation; Cell Membrane; Cytoplasmic Granules; Cytosol; Enzyme Activation; Granulomatous Disease, Chronic; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Tetradecanoylphorbol Acetate | 1986 |
A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Choline; Diglycerides; Dogs; Glycerides; Kidney; Palmitic Acid; Palmitic Acids; Phorbols; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1986 |
Lipoxygenation of arachidonic acid by differentiated and undifferentiated human promyelocytic HL-60 cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Dimethyl Sulfoxide; Humans; Leukemia, Myeloid, Acute; Lipoxygenase; Tetradecanoylphorbol Acetate | 1986 |
Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Concanavalin A; Cycloheximide; Deoxyglucose; Emetine; Female; Hydrogen Peroxide; Kinetics; Lectins; Macrophages; Mice; Mice, Inbred ICR; Oxidation-Reduction; Oxygen Consumption; Tetradecanoylphorbol Acetate; Thrombin; Wheat Germ Agglutinins | 1986 |
Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen.
Topics: Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Benzofurans; Blood Platelets; Calcium; Collagen; Cytosol; Ethers; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Ionomycin; Lipids; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced induction of Epstein-Barr virus early antigen in Raji cells by some inhibitors of tumor promotion.
Topics: Antigens, Viral; Antioxidants; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Flavonoids; Indomethacin; Ornithine Decarboxylase Inhibitors; Protease Inhibitors; Steroids; Tetradecanoylphorbol Acetate | 1986 |
Antioxidants and blockers of arachidonate metabolism inhibit the mitogenic effects of TPA in hepatocytes: differences in the operative mechanisms according to the cell cycle setting.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Cell Cycle; Glutathione; Kinetics; Lipoxygenase; Liver; Mitosis; Rats; Tetradecanoylphorbol Acetate; Thromboxane-A Synthase; Vitamin E | 1986 |
Mechanisms of action of gonadotropin releasing hormone on rat granulosa cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; In Vitro Techniques; Progesterone; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Tetradecanoylphorbol Acetate | 1986 |
In vitro formation of activators for prostaglandin synthesis by neutrophils and macrophages from humans and guinea pigs.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Catalase; Enzyme Activation; Glutathione Peroxidase; Guinea Pigs; HEPES; Humans; Hydrogen Peroxide; Leukotrienes; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Studies on the mechanisms by which tumor promoters stimulate the growth of primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Antioxidants; Arachidonic Acid; Arachidonic Acids; Calcium; Carcinogens; Cell Division; Cells, Cultured; DNA; Liver; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Humans; Lipopolysaccharides; Monocytes; Prostaglandins E; Radioimmunoassay; Secretory Rate; Tetradecanoylphorbol Acetate; Thromboxane B2; Time Factors | 1986 |
Modulation of arachidonic acid metabolism in a cultured newborn rat keratinocyte cell line.
Topics: Animals; Animals, Newborn; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cell Line; Dexamethasone; Diglycerides; Epidermal Growth Factor; Melitten; Prostaglandin-Endoperoxide Synthases; Rats; Skin; Tetradecanoylphorbol Acetate | 1987 |
Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
sn-1,2-Diacylglycerols and phorbol diesters stimulate thromboxane synthesis by de novo synthesis of prostaglandin H synthase in human promyelocytic leukemia cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Cell Line; Diglycerides; Glycerides; Humans; Kinetics; Leukemia, Myeloid; Macrophages; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2; Trifluoperazine | 1987 |
Comparison of subcellular activation of the human neutrophil NADPH-oxidase by arachidonic acid, sodium dodecyl sulfate (SDS), and phorbol myristate acetate (PMA).
Topics: Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protein Kinase C; Sodium Dodecyl Sulfate; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1987 |
Differential effects of protoporphyrin and uroporphyrin on murine mast cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Calcium; Carbon Radioisotopes; Cell Membrane; Free Radicals; Mast Cells; Mice; Mice, Inbred BALB C; Oxygen; Porphyrins; Protoporphyrins; Serotonin; Tetradecanoylphorbol Acetate; Uroporphyrins; X-Rays | 1987 |
Effects of TPA on short-circuit current across frog skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Dose-Response Relationship, Drug; Electric Conductivity; Epithelium; Hydrogen-Ion Concentration; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Tetradecanoylphorbol Acetate; Vasopressins | 1987 |
Diacylglycerol induces deacylation of phosphatidylinositol and mobilization of arachidonic acid in mouse macrophages. Comparison with induction by phorbol diester.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cells, Cultured; Chlorpromazine; Diglycerides; Dose-Response Relationship, Drug; Female; Glycerides; Macrophages; Mice; Phosphatidylinositols; Phospholipids; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Phorbol ester-induced formation of clastogenic factor from human monocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Chromosome Aberrations; Humans; Leukotrienes; Lipid Metabolism; Lipid Peroxides; Monocytes; Mutagens; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1987 |
Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Indomethacin; Isoquinolines; Kidney; Lysophosphatidylcholines; Molecular Weight; Phospholipid Ethers; Phosphorylation; Piperazines; Prostaglandins; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Early changes in the arachidonic acid metabolism of HeLa cells in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and related compounds.
Topics: Arachidonic Acid; Arachidonic Acids; Carcinogens; Culture Media; Cycloheximide; Dinoprostone; HeLa Cells; Humans; Membrane Lipids; Mitogens; Phorbol Esters; Phospholipids; Prostaglandins E; Tetradecanoylphorbol Acetate; Time Factors | 1987 |
Effect of phorbol and glucose on insulin secretion from the human fetal pancreas.
Topics: Arachidonic Acid; Arachidonic Acids; Fetus; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lipid Metabolism; Perfusion; Tetradecanoylphorbol Acetate | 1987 |
Dynamic actions of arachidonic acid and protein kinase C in pituitary stimulation by gonadotropin-releasing hormone.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Masoprocol; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Retinaldehyde; Tetradecanoylphorbol Acetate | 1987 |
Luteinizing hormone-releasing hormone (LHRH)-induced arachidonic acid release in rat granulosa cells. Role of calcium and protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; In Vitro Techniques; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1987 |
A novel synthetic vitamin A-like compound (a polyprenoic acid derivative, E-5166) inhibits the release of arachidonic acid stimulated by epidermal growth factor.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Epidermal Growth Factor; Phosphatidylinositols; Skin; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1987 |
Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; DNA Replication; Female; Flurbiprofen; Indomethacin; Mice; Ornithine Decarboxylase; Prostaglandins E; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1987 |
Signal response transduction in rabbit neutrophil leucocytes. The effects of exogenous phospholipase A2 suggest two pathways exist.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Luminescent Measurements; Lymphocyte Activation; Lysophosphatidylcholines; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Rabbits; Tetradecanoylphorbol Acetate | 1987 |
In vitro inhibition of rat brain protein kinase C by rhodamine 6G. Profound effects of the lipid cofactor on the inhibition of the enzyme.
Topics: Animals; Antineoplastic Agents; Arachidonic Acid; Arachidonic Acids; Brain; Lipids; Phosphorylation; Protamines; Protein Kinase C; Rats; Rhodamines; Tetradecanoylphorbol Acetate; Xanthenes | 1987 |
Effects of the phorbolester TPA and of the ionophore A 23187 on phospholipase A2 and C activities in the mouse epidermal cell line HEL-30.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carcinogens; Cell Line; Dinoprostone; Enzyme Activation; Epidermis; Mice; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Prostaglandins E; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1987 |
Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprostone; Macrophages; Peritoneal Cavity; Plant Extracts; Prostaglandins E; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thapsigargin | 1987 |
Stimulation of prostaglandin E2 production by phorbol esters and epidermal growth factor in porcine thyroid cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Epidermal Growth Factor; Kinetics; Prostaglandins E; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1987 |
Arachidonic acid is involved in the regulation of hCG induced steroidogenesis in rat Leydig cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Chorionic Gonadotropin; In Vitro Techniques; Kinetics; Leydig Cells; Male; Masoprocol; Rats; Testosterone; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1987 |
Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets.
Topics: Aluminum; Aluminum Compounds; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Dose-Response Relationship, Drug; Epoprostenol; Fluorides; Fluorine; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Neomycin; Pertussis Toxin; Sodium Fluoride; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thromboxane B2; Thromboxanes; Time Factors; Virulence Factors, Bordetella | 1987 |
[Effects of benzydamine on leukocyte aggregation].
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzydamine; Calcimycin; Cell Aggregation; Cell Survival; Exudates and Transudates; In Vitro Techniques; Leukocytes; Male; N-Formylmethionine Leucyl-Phenylalanine; Phagocytes; Pyrazoles; Rats; Tetradecanoylphorbol Acetate | 1987 |
Inhibition of phospholipase A2 (PLA2) activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Carbon Radioisotopes; Dose-Response Relationship, Drug; Humans; Inflammation; Macrophages; Male; Mice; Nifedipine; Nisoldipine; Peritoneal Cavity; Phospholipases; Phospholipases A; Phospholipases A2; SRS-A; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1987 |
Phorbol ester-induced changes in cytoplasmic Ca2+ in human neutrophils. Involvement of a pertussis toxin-sensitive G protein.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cations, Monovalent; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Kinetics; Manganese; Neutrophils; Nigericin; Pertussis Toxin; Sodium; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1987 |
Activation of protein kinase C is coupled to prostaglandin E2 synthesis in swine granulosa cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Dinoprostone; Drug Synergism; Enzyme Activation; Female; Follicle Stimulating Hormone; Gas Chromatography-Mass Spectrometry; Granulosa Cells; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandins E; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate | 1987 |
Phorbol ester stimulation of prostanoid synthesis by cultured astrocytes.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Calcimycin; Calcium; Cells, Cultured; Cerebral Cortex; Prostaglandins; Protein Kinase C; Quinacrine; Rats; Tetradecanoylphorbol Acetate | 1987 |
Specific inhibition of phorbol diester-induced granulocyte-macrophage progenitor cell (GM-CFU) differentiation by lipoxygenase inhibitors.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Butylated Hydroxyanisole; Cell Differentiation; Colony-Forming Units Assay; Dexamethasone; Granulocytes; Hematopoietic Stem Cells; Ibuprofen; Indomethacin; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mice; Tetradecanoylphorbol Acetate | 1987 |
Role of arachidonic acid release in the G2 delay induced by tumor promoter TPA in HeLa cells.
Topics: Arachidonic Acid; Arachidonic Acids; Fluocinolone Acetonide; HeLa Cells; Humans; Interphase; Mitosis; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate | 1987 |
Epidermal growth factor (EGF), tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and calcium ionophore A23187 increase cytoplasmic free calcium and stimulate arachidonic acid release and PGE2/6-keto PGF1 alpha production in cultured porcine thyroi
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Benzofurans; Calcimycin; Calcium; Cells, Cultured; Cytoplasm; Dinoprostone; Epidermal Growth Factor; Fluorescent Dyes; Fura-2; Kinetics; Prostaglandins; Prostaglandins E; Spectrometry, Fluorescence; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1987 |
Role for protein kinase C in A23187 induced glomerular arachidonate release and PGE2 production.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dinoprostone; Female; Kidney Glomerulus; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C mediates endotoxin and zymosan-induced prostaglandin synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Wall; Dinoprostone; Endotoxins; Leukemia, Experimental; Mice; Prostaglandins; Prostaglandins E; Protein Kinase C; Tetradecanoylphorbol Acetate; Zymosan | 1987 |
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1987 |
Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Dinoprostone; Drug Synergism; Epidermal Growth Factor; Glomerular Mesangium; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Vasopressins | 1988 |
Role of arachidonic acid in luteinizing hormone-releasing hormone action: stimulation of progesterone production in rat granulosa cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diglycerides; Drug Interactions; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; Indomethacin; Inositol; Kinetics; Masoprocol; Progesterone; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Inability of murine peritoneal macrophages to convert linoleic acid into arachidonic acid. Evidence of chain elongation.
Topics: Acetyltransferases; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Carbon Radioisotopes; Fatty Acid Elongases; Fatty Acids; Female; Linoleic Acid; Linoleic Acids; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Phospholipids; Tetradecanoylphorbol Acetate; Zymosan | 1988 |
Demonstration of calcium-dependent phospholipase A2 activity in membrane preparation of rabbit neutrophils. Absence of activation by fMet-Leu-Phe, phorbol 12-myristate 13-acetate and A-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Membrane; Enzyme Activation; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate | 1988 |
Labelling of lipids and phospholipids with [3H]arachidonic acid and the biosynthesis of eicosanoids in U937 cells differentiated by phorbol ester.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Line; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Eicosanoic Acids; Fatty Acids, Nonesterified; Humans; Lipid Metabolism; Lymphoma, Large B-Cell, Diffuse; Microscopy, Electron, Scanning; Phospholipids; Tetradecanoylphorbol Acetate | 1988 |
The development of contact hypersensitivity in mouse skin is suppressed by tumor promoters.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoyl Peroxide; Carcinogens; Dermatitis, Contact; Dinitrochlorobenzene; Diterpenes; Female; Immunosuppressive Agents; Mice; Terpenes; Tetradecanoylphorbol Acetate | 1988 |
Inflammation, oxidative DNA damage, and carcinogenesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; DNA Damage; Hydrogen Peroxide; Inflammation; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oxidation-Reduction; Tetradecanoylphorbol Acetate | 1987 |
Effect of chemotactic factors on hexose transport in polymorphonuclear leucocytes.
Topics: 3-O-Methylglucose; Arachidonic Acid; Arachidonic Acids; Biological Transport; Blood; Calcimycin; Chemotactic Factors; Deoxyglucose; Glucose; Hexoses; Humans; Kinetics; Methylglucosides; Monosaccharide Transport Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Thrombin; Zymosan | 1988 |
Characteristics of bradykinin and TPA increases in the PGE2 levels of human urothelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium; Cells, Cultured; Cycloheximide; Dinoprostone; Dose-Response Relationship, Drug; Epithelium; Humans; In Vitro Techniques; Prostaglandins E; Tetradecanoylphorbol Acetate; Ureter | 1988 |
Dual effect of the phorbol ester TPA on arachidonic acid release from HeLa cells.
Topics: Arachidonic Acid; Arachidonic Acids; Cycloheximide; HeLa Cells; Humans; Kinetics; Phospholipids; Tetradecanoylphorbol Acetate | 1988 |
Effect of phorbol 12-myristate 13-acetate on collagen-induced signal transduction in rabbit platelet.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Communication; Collagen; In Vitro Techniques; Lipid Metabolism; Phosphatidic Acids; Platelet Aggregation; Rabbits; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1988 |
Desensitization of pituitary gonadotropes by mediators of LH release.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Female; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bryostatins; Cell Line; Dogs; Lactones; Macrolides; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dinoprostone; Gossypol; Macrophages; Male; Peritoneal Cavity; Plant Extracts; Prostaglandins E; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin | 1988 |
Gonadal steroid effects on LH response to arachidonic acid and protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Enzyme Activation; Estradiol; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Melitten; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Testosterone; Tetradecanoylphorbol Acetate | 1988 |
The alpha 1-adrenergic transduction system in hamster brown adipocytes. Release of arachidonic acid accompanies activation of phospholipase C.
Topics: Adipose Tissue, Brown; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Colforsin; Cricetinae; Cyclohexanones; Egtazic Acid; Enzyme Activation; In Vitro Techniques; Inositol Phosphates; Insulin; Isoproterenol; Lipid Metabolism; Male; Phenylephrine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Catechols; Chlorogenic Acid; Cinnamates; Coumaric Acids; Curcumin; DNA; Edema; Female; Mice; Ornithine Decarboxylase; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1988 |
Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Enzyme Activation; Gallic Acid; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2 | 1988 |
Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Cytoplasm; In Vitro Techniques; Isoquinolines; Lyngbya Toxins; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Piperazines; Plant Extracts; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin | 1988 |
Exogenous arachidonic acid promotes insulin release from intact or permeabilized rat islets by dual mechanisms. Putative activation of Ca2+ mobilization and protein kinase C.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Radioisotopes; Cell Membrane Permeability; Cold Temperature; Dantrolene; Digitonin; Drug Synergism; Enzyme Activation; Ethers; Glucose; Insulin; Insulin Secretion; Ionomycin; Islets of Langerhans; Kinetics; Protein Kinase C; Quinacrine; Rats; Sodium; Tetradecanoylphorbol Acetate; Trifluoperazine | 1988 |
Platelet aggregation is inhibited by long chain acyl-CoA.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Coenzyme A; Diglycerides; Dose-Response Relationship, Drug; Humans; Kinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetradecanoylphorbol Acetate; Thrombin | 1988 |
Effects of retinoids and inhibitors of arachidonic acid metabolism on tumor-promoter-induced soft agar colony formation of mouse epidermal cells and rat urinary bladder cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Colony-Forming Units Assay; Diterpenes; Epidermis; Female; Male; Masoprocol; Mice; Quinacrine; Rats; Rats, Inbred F344; Retinoids; Retinyl Esters; Saccharin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay; Urinary Bladder Neoplasms; Vitamin A | 1988 |
Dependence of secretory responses to gonadotropin-releasing hormone on diacylglycerol metabolism. Studies with a diacylglycerol lipase inhibitor, RHC 80267.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclohexanes; Cyclohexanones; Diglycerides; Ethers; Female; Follicle Stimulating Hormone; Glycerides; Gonadotropin-Releasing Hormone; Ionomycin; Lipoprotein Lipase; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; Tetradecanoylphorbol Acetate | 1988 |
Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro.
Topics: Arachidonic Acid; Arachidonic Acids; Biological Transport; Cell Differentiation; Cell Division; Fatty Acids; Hematopoiesis; Humans; Linoleic Acid; Linoleic Acids; Lipid Metabolism; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Arachidonic acid metabolism in HEL/30 murine epidermal cell line.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Epidermis; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Mice; Tetradecanoylphorbol Acetate | 1988 |
Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases.
Topics: 6-Ketoprostaglandin F1 alpha; Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dinoprostone; In Vitro Techniques; Macrophages; Male; Mice; Phospholipases; Phospholipases A; Phospholipases A2; SRS-A; Terpenes; Tetradecanoylphorbol Acetate; Zymosan | 1988 |
Tumor promoter-stimulated protein phosphorylation in mouse epidermis is inhibited by bromophenacyl bromide.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Epidermis; Female; Mice; Mice, Inbred ICR; Phorbols; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 1985 |
Effects of trifluoperazine on platelet activation.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Epinephrine; Humans; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein Kinase Inhibitors; Serotonin; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2; Trifluoperazine | 1985 |
Arachidonic acid release and catecholamine secretion from digitonin-treated chromaffin cells: effects of micromolar calcium, phorbol ester, and protein alkylating agents.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Chromaffin Granules; Chromaffin System; Digitonin; Ethylmaleimide; Exocytosis; Lipid Metabolism; Magnesium; Norepinephrine; Phorbols; Tetradecanoylphorbol Acetate | 1985 |
Response of Walker 256 carcinosarcoma cells to 12-O-tetradecanoylphorbol 13-acetate: possible regulation by endogenous cyclooxygenase metabolites.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinoma 256, Walker; Cell Adhesion; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Indomethacin; Neoplasm Transplantation; Phorbols; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate | 1985 |
Cyclosporin A inhibits biological effects of tumor promoting phorbol esters.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Transformation, Neoplastic; Chromatography, Thin Layer; Cyclosporins; Edema; Female; Mice; Phorbols; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acid; Arachidonic Acids; Interferon-gamma; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Peritoneal Cavity; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Prostaglandins; SRS-A; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1985 |
Intracellular calcium does not appear to be essential for arachidonic acid release from stimulated macrophages as shown by studies with Quin-2.
Topics: Aminoquinolines; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Egtazic Acid; In Vitro Techniques; Lipids; Macrophage Activation; Macrophages; Male; Mice; Tetradecanoylphorbol Acetate; Zymosan | 1985 |
Calcium ionophore enables soluble agonists to stimulate macrophage 5-lipoxygenase.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Calcimycin; Enzyme Activation; In Vitro Techniques; Latex; Lipoxygenase; Macrophages; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; SRS-A; Tetradecanoylphorbol Acetate; Zymosan | 1985 |
Regulation of arachidonic acid metabolism in macrophages by immune and nonimmune interferons.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dinoprostone; Female; Interferon Type I; Interferon-gamma; Macrophages; Male; Mice; Mice, Inbred C3H; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate; Thromboxane B2; Zymosan | 1985 |
Regulation of arachidonic acid metabolism in Madin-Darby canine kidney cells: stimulation of synthesis of the cyclooxygenase system by 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dactinomycin; Dogs; Enzyme Induction; Kidney; Kinetics; Phorbols; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1985 |
Arachidonic acid metabolism in cultured mouse keratinocytes.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Arachidonic Acids; Blood; Calcimycin; Cells, Cultured; Culture Media; Dinoprostone; Mice; Phospholipases; Phospholipids; Prostaglandins E; Skin; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tritium | 1985 |
The stimulation of prostaglandin production by transforming growth factor-alpha and 12-O-tetradecanoyl-phorbol-13-acetate or 1-oleoyl-2-acetyl-glycerol is synergistic.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Diglycerides; Drug Synergism; Glycerides; Growth Substances; Humans; Kidney; Liver; Lung; Peptides; Phorbols; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
Arachidonic acid metabolism in murine fibrosarcoma cells with differing in vivo and in vitro characteristics.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Adhesion; Cell Line; Chemotaxis; Dinoprostone; Fibronectins; Fibrosarcoma; Laminin; Lipoxygenase; Mice; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1985 |
Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Diglycerides; Enzyme Activation; Fatty Acids, Unsaturated; Glycerides; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Phorbols; Phospholipases A; Phospholipases A2; Phospholipids; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1985 |
Modulation of phospholipid metabolism in murine keratinocytes by tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cells, Cultured; Eicosanoic Acids; Lipoxygenase; Membrane Lipids; Mice; Mice, Inbred BALB C; Phorbols; Phospholipids; Skin; Stearic Acids; Tetradecanoylphorbol Acetate | 1985 |
Similar effects of phospholipase C and phorbol ester tumor promoters on primary mouse epidermal cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cells, Cultured; Diglycerides; Enzyme Induction; Epidermal Growth Factor; Epidermis; Mice; Mice, Inbred BALB C; Ornithine Decarboxylase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1985 |
Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate-like mechanism.
Topics: Arachidonic Acid; Arachidonic Acids; Biomechanical Phenomena; Cations, Divalent; Cell Aggregation; Cytochalasin B; Diglycerides; Diterpenes; Drug Resistance; Glycerides; Humans; Neutrophils; Phorbols; Terpenes; Tetradecanoylphorbol Acetate | 1985 |
Involvement of arachidonic acid metabolites in acute inflammation: detection of 6-keto-PGF1 alpha, thromboxane B2 and PGD2 in rat pleurisy induced by phorbol myristate acetate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Inflammation; Male; Platelet Aggregation; Pleurisy; Prostaglandin D2; Prostaglandins D; Radioimmunoassay; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1985 |
Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Edema; Female; Lipoxygenase Inhibitors; Methylprednisolone; Mice; Mice, Inbred Strains; Otitis Externa; Pyrazoles; Tetradecanoylphorbol Acetate | 1985 |
Lipid peroxidation products and clastogenic material in culture media of human leukocytes exposed to the tumor promoter phorbol-myristate-acetate.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Chromosome Aberrations; Culture Media; Dose-Response Relationship, Drug; Free Radicals; Humans; Leukocytes; Lipid Peroxides; Malondialdehyde; Oxygen; Phorbols; Tetradecanoylphorbol Acetate; Thiobarbiturates | 1985 |
Retention of the glycoprotein IIb-IIIa complex in the isolated platelet cytoskeleton. Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Fractionation; Cell Membrane; Cytoskeleton; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Glycoproteins; Humans; Kinetics; Membrane Proteins; Molecular Weight; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1984 |
Eicosapentaenoic acid: its effects on arachidonic acid metabolism by cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Cell Line; Cells, Cultured; Dogs; Eicosapentaenoic Acid; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Liver; Mice; Prostaglandins; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 1984 |
Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Alprostadil; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lipids; Platelet Aggregation; Propranolol; Prostaglandins E; Solubility; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1984 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin: examination of biochemical effects involved in the proliferation and differentiation of XB cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Cycle; Cell Differentiation; Cells, Cultured; Cholera Toxin; Cyclic AMP; Dioxins; Epidermal Growth Factor; Keratins; Mice; Phospholipids; Polychlorinated Dibenzodioxins; Tetradecanoylphorbol Acetate | 1984 |
Modulation of skin tumor promotion by inhibitors of arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cell Line; Cricetinae; Cricetulus; Cyclooxygenase Inhibitors; Lipoxygenase Inhibitors; Lung; Mice; Neoplasms, Experimental; Phospholipases A; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cattle; Chemotactic Factors; Cytochalasin B; Cytoplasmic Granules; Humans; In Vitro Techniques; Leukotriene B4; Lysophosphatidylcholines; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Platelet Activating Factor; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1981 |
A possible role of protein alkylation in phorbol ester action.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Alkylation; Animals; Arachidonic Acid; Arachidonic Acids; Cattle; Choline-Phosphate Cytidylyltransferase; Enzyme Activation; Lymphocyte Activation; Lymphocytes; Nucleotidyltransferases; Oxygen; Phorbols; Phosphatidylcholines; Phytohemagglutinins; Proteins; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils.
Topics: Alprostadil; Arachidonic Acid; Arachidonic Acids; Epoprostenol; Humans; In Vitro Techniques; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oligopeptides; Oxygen; Prostaglandins; Prostaglandins E, Synthetic; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
Activation of murine macrophage cell lines. Possible involvement of protein kinases in stimulation of superoxide production.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Ion Channels; Macrophage Activation; Macrophages; Membrane Lipids; Membrane Potentials; Mice; Phosphorylation; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate | 1984 |
Tachyphylaxis in 12-0-tetradecanoylphorbol acetate- and arachidonic acid-induced ear edema.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ear; Edema; Female; Kinetics; Mice; Phorbols; Tachyphylaxis; Tetradecanoylphorbol Acetate; Vasodilation | 1983 |
12-O-tetradecanoylphorbol-13-acetate stimulates release of arachidonic acid, prostaglandin E2 and prostaglandin F2 alpha from TPA nonproliferative variants of 3T3 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Division; Cell Line; Dinoprost; Dinoprostone; Fibroblasts; Mice; Phorbols; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1983 |
Induction of plasminogen activator by 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore. Suppression by inhibitors of fatty acid lipoxygenase.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Calcimycin; Catechols; Cells, Cultured; Enzyme Induction; Fatty Acids; HeLa Cells; Humans; Hydroxyeicosatetraenoic Acids; Leukemia, Experimental; Lipoxygenase Inhibitors; Masoprocol; Phorbols; Plasminogen Activators; Rats; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzamides; Carboxy-Lyases; Cell Membrane; Cells, Cultured; Embryo, Mammalian; Female; Histidine Decarboxylase; Kinetics; Membrane Lipids; Mice; Phorbols; Phospholipids; Pregnancy; Rats; Salicylates; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Stimulation of deacylation in Madin-Darby canine kidney cells. 12-O-tetradecanoyl-phorbol-13-acetate stimulates rapid phospholipid deacylation.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Dogs; Indomethacin; Kidney; Kinetics; Phorbols; Phospholipids; Prostaglandins; Tetradecanoylphorbol Acetate | 1983 |
Demonstration of two unique metabolites of arachidonic acid from phorbol ester-stimulated bovine lymphocytes.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Cattle; Cyclooxygenase Inhibitors; Enzyme Activation; Kinetics; Lipoxygenase; Lipoxygenase Inhibitors; Lymphocyte Activation; Lymphocytes; Masoprocol; Phorbol Esters; Phorbols; Tetradecanoylphorbol Acetate | 1983 |
Regulation of arachidonic acid metabolism in Madin-Darby canine kidney cells. Comparison of A23187 and 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cycloheximide; Dinoprostone; Dogs; Kidney; Phorbols; Prostaglandins E; Tetradecanoylphorbol Acetate | 1984 |
Inhibition of tumor promotion by a lecanoric acid analogue.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Female; Histidine Decarboxylase; Mice; Salicylamides; Salicylanilides; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Arachidonic acid metabolism and thyrotropin secretion in vitro.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Catechols; Female; In Vitro Techniques; Indomethacin; Masoprocol; Phospholipases A; Phospholipases A2; Pituitary Gland; Pyrazoles; Quinacrine; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thyrotropin; Thyrotropin-Releasing Hormone | 1984 |
Synthesis of prostaglandin F by cultured human endometrial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bradykinin; Cells, Cultured; Dose-Response Relationship, Drug; Endometrium; Estradiol; Female; Histamine; Humans; Hydrocortisone; In Vitro Techniques; Prostaglandins F; Quinacrine; Tetradecanoylphorbol Acetate | 1984 |
Characteristics of cyclosporine induction of increased prostaglandin levels from human peripheral blood monocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cyclosporins; Humans; Indomethacin; Kinetics; Lipopolysaccharides; Monocytes; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Tetradecanoylphorbol Acetate | 1984 |
Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcitriol; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Epidermal Growth Factor; Kinetics; Osteoblasts; Parathyroid Hormone; Prostaglandins; Tetradecanoylphorbol Acetate; Thrombin; Tritium | 1984 |
Activation of the metabolism of the fatty acyl group in granulocyte phospholipids by phorbol myristate acetate.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Fatty Acids; Glycerol; Granulocytes; Guinea Pigs; Kinetics; Palmitic Acid; Palmitic Acids; Phorbols; Phospholipids; Tetradecanoylphorbol Acetate | 1981 |
Source of arachidonic acid for prostaglandin synthesis in Madin-Darby canine kidney cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Dogs; Kidney; Kinetics; Palmitic Acid; Palmitic Acids; Phospholipids; Prostaglandins; Tetradecanoylphorbol Acetate | 1981 |
Phospholipase activity in skin after application of phorbol esters and 3-methylcholanthrene.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; DNA; Male; Methylcholanthrene; Mice; Phorbol Esters; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Skin; Tetradecanoylphorbol Acetate | 1981 |
Early induction of the arachidonic acid cascade and stimulation of DNA synthesis by TPA in murine and guinea pig epidermal cells in culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Cells, Cultured; Dinoprost; Dinoprostone; DNA; Epidermis; Guinea Pigs; Indomethacin; Mice; Ornithine Decarboxylase; Phorbols; Prostaglandins E; Prostaglandins F; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Carboxy-Lyases; Catechols; Dinoprostone; Female; Indomethacin; Lipoxygenase Inhibitors; Masoprocol; Mice; Ornithine Decarboxylase; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandins E; Quinacrine; Skin; Tetracaine; Tetradecanoylphorbol Acetate | 1982 |
Calcium-dependent release of arachidonic acid from a murine epidermal cell line induced by the tumor promoter TPA or ionophore A 23187: dissection of ionophoretic and phospholipase A2-stimulating activity.
Topics: Animals; Anti-Bacterial Agents; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcimycin; Calcium; Cell Line; Enzyme Activation; Ionophores; Mice; Phorbols; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate | 1982 |
Stimulation of deacylation in Madin-Darby canine kidney cells. Specificity of deacylation and prostaglandin production in 12-O-tetradecanoylphorbol-13-acetate-treated cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cell Line; Dogs; Fatty Acids, Unsaturated; Kidney; Kinetics; Linoleic Acid; Linoleic Acids; Phorbols; Prostaglandins; Tetradecanoylphorbol Acetate | 1982 |
Resistance of A-431 epidermoid carcinoma cells to early membrane changes induced by tumour promoters.
Topics: Arachidonic Acid; Arachidonic Acids; Carcinogens; Carcinoma, Squamous Cell; Cells, Cultured; Choline; Drug Resistance; Humans; Membranes; Neoplasms, Experimental; Phospholipids; Tetradecanoylphorbol Acetate | 1982 |
Anti-inflammatory properties of Gö 6850: a selective inhibitor of protein kinase C.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprostone; Enzyme Inhibitors; Female; Hypersensitivity, Delayed; Indoles; Macrophages, Peritoneal; Maleimides; Mice; Mice, Inbred BALB C; Neutrophils; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Influence of calcium on arachidonic acid mobilization by murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Ionophores; Macrophages, Peritoneal; Male; Mice; Phospholipases A; Phospholipases A2; Protein Kinase C; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells.
Topics: Arachidonic Acid; Blood Coagulation Factors; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation; Humans; Hydroxyeicosatetraenoic Acids; Leukotrienes; Lipid Peroxides; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thromboplastin; Tumor Necrosis Factor-alpha; Umbilical Veins | 1995 |
Ligands of purinergic receptors stimulate electrogenic H(+)-transport of neutrophils.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Proton-Translocating ATPases; Purinergic P2 Receptor Agonists; Ribonucleotides; Swine; Tetradecanoylphorbol Acetate | 1995 |
Protein kinase C activation precedes arachidonic acid release during IgG-mediated phagocytosis.
Topics: Arachidonic Acid; Cells, Cultured; Enzyme Activation; Ethers, Cyclic; Humans; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Melitten; Monocytes; Okadaic Acid; Peptides; Phagocytosis; Phospholipases A; Phospholipases A2; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Time Factors; Wasp Venoms | 1995 |
SCF/c-kit receptor-mediated arachidonic acid liberation in rat mast cells. Involvement of PLD activation associated tyrosine phosphorylation.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Diglycerides; Genistein; Hematopoietic Cell Growth Factors; Isoflavones; Kinetics; Mast Cells; Myristic Acid; Myristic Acids; Phosphatidylcholines; Propranolol; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptors, Colony-Stimulating Factor; Stem Cell Factor; Tetradecanoylphorbol Acetate; Vanadates | 1993 |
Priming of human monocyte superoxide production and arachidonic acid metabolism by adherence to collagen- and basement membrane-coated surfaces.
Topics: Antigens, CD; Arachidonic Acid; Basement Membrane; Carrier Proteins; Cell Adhesion; Cells, Cultured; Collagen; Humans; Hyaluronan Receptors; Integrin beta1; Integrins; Monocytes; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.
Topics: Acute-Phase Proteins; Alkaloids; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Carrier Proteins; CHO Cells; Cricetinae; Cricetulus; Cytosol; Humans; Leukotriene B4; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Lymphocytes possess an electrogenic H(+)-transporting pathway in their plasma membrane.
Topics: Animals; Arachidonic Acid; Cadmium; Cations, Divalent; Cell Membrane; Dicyclohexylcarbodiimide; Fatty Acids, Unsaturated; Hydrogen-Ion Concentration; Ion Channels; Lymphocytes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Protein Kinase C; Protons; Swine; Tetradecanoylphorbol Acetate | 1994 |
Lipopolysaccharide primes human basophils for enhanced mediator release: requirement for plasma co-factor and CD14.
Topics: Acute-Phase Proteins; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arachidonic Acid; Basophils; Calcimycin; Carrier Proteins; Histamine Release; Humans; Immunoglobulin E; Kinetics; Lipopolysaccharide Receptors; Lipopolysaccharides; Membrane Glycoproteins; N-Formylmethionine Leucyl-Phenylalanine; Tetradecanoylphorbol Acetate | 1994 |
Translocation of protein kinase C isozymes in lactotroph-enriched rat anterior pituitary cell cultures: differential effects of substance P and phorbol ester.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Arachidonic Acid; Biological Transport; Calcium; Diglycerides; Enzyme Activation; Isoenzymes; Male; Molecular Sequence Data; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipases A; Phosphoric Diester Hydrolases; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Substance P; Tetradecanoylphorbol Acetate | 1994 |
Induction of serine and threonine protein phosphorylation by endotoxin-associated protein in murine resident peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Bacterial Proteins; Dinoprostone; Endotoxins; Female; Ionomycin; Lipid A; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C3H; Molecular Weight; Phosphoproteins; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tyrosine | 1995 |
Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets.
Topics: Arachidonic Acid; Blood Platelets; Botulinum Toxins; Calcium; Dose-Response Relationship, Drug; GTP-Binding Proteins; Histamine Release; Humans; In Vitro Techniques; Kinetics; Pertussis Toxin; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin; Virulence Factors, Bordetella | 1995 |
Cyclic AMP-increasing agents interfere with chemoattractant-induced respiratory burst in neutrophils as a result of the inhibition of phosphatidylinositol 3-kinase rather than receptor-operated Ca2+ influx.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arachidonic Acid; Biological Transport, Active; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guinea Pigs; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Peptide; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Alkaloids; Arachidonic Acid; Cycloheximide; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; In Vitro Techniques; Inflammation Mediators; Interleukin-1; Interleukin-8; Leukotriene B4; Lipoxygenase Inhibitors; Phospholipases A; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Role of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages: regulation by Ca2+ and phosphorylation.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Activation; Kinetics; Lipopolysaccharides; Liver; Macrophages; Male; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Zymosan | 1995 |
The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase A2. Effects of the dominant negative G alpha i2 mutant, [G203T]G alpha i2, on activation of phospholipase A2 in Chinese hamster ovary cells.
Topics: Animals; Arachidonic Acid; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cyclic AMP; Enzyme Activation; GTP-Binding Proteins; Ionomycin; Molecular Sequence Data; Phospholipases A; Phospholipases A2; Phosphorylation; Tetradecanoylphorbol Acetate | 1995 |
The antiinflammatory activity of topically applied novel calcium-channel antagonists.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcium; Calcium Channel Blockers; Chemotaxis, Leukocyte; Clobetasol; Ear, External; Epidermis; Female; Humans; Hyperplasia; Inflammation; Mice; Neutrophils; Nifedipine; Peroxidase; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phospholipases A; Phosphoric Diester Hydrolases; Pituitary Neoplasms; Potassium Chloride; Pyrazoles; Terpenes; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1995 |
Phospholipase C activates protein kinase C during induction of slow Na current in Xenopus oocytes.
Topics: Animals; Arachidonic Acid; Diglycerides; Enzyme Activation; Female; Neomycin; Oocytes; Phosphorylation; Protein Kinase C; Sodium Channel Blockers; Sodium Channels; Tetradecanoylphorbol Acetate; Type C Phospholipases; Xenopus laevis | 1995 |
A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions.
Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonic Acid; Cell Survival; Edema; Eicosanoids; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Leukocyte Elastase; Lipid Peroxidation; Mice; Neutrophils; Pancreatic Elastase; Pyrrolidines; Rats; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Arachidonic acid increases cytosolic calcium and stimulates hormone release in rat lactotrophs.
Topics: Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Line; Cells, Cultured; Cobalt; Cytosol; Dose-Response Relationship, Drug; Female; Kinetics; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactin; Rats; Rats, Wistar; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Thyrotropin-Releasing Hormone; Time Factors; Tumor Cells, Cultured | 1995 |
Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase
Topics: Animals; Arachidonic Acid; Enzyme Inhibitors; Lipopolysaccharides; Macrophages, Alveolar; Male; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Effects of an anti-inflammatory peptide (antiflammin 2) on cell influx, eicosanoid biosynthesis and oedema formation by arachidonic acid and tetradecanoyl phorbol dermal application.
Topics: Acetylglucosaminidase; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capillary Permeability; Dexamethasone; Dinoprostone; Ear Diseases; Edema; Eicosanoids; Indomethacin; Leukotriene B4; Male; Mice; Oligopeptides; Peptide Fragments; Peroxidase; Tetradecanoylphorbol Acetate | 1995 |
Angiotensin II activates the Na+/HCO3- symport through a phosphoinositide-independent mechanism in cardiac cells.
Topics: Alkaloids; Amiloride; Angiotensin II; Animals; Animals, Newborn; Arachidonic Acid; Benzopyrans; Bicarbonates; Carrier Proteins; Cells, Cultured; Dithiothreitol; Heart; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; Kinetics; Myocardium; Naphthols; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Rhodamines; Sodium-Bicarbonate Symporters; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Arachidonic acid increases the activity of the assembled NADPH oxidase in cytoplasmic membranes and endosomes.
Topics: Arachidonic Acid; Cytoplasm; Dextrans; Enzyme Activation; Fluorescein-5-isothiocyanate; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of expression of protein kinase C alpha by antisense cDNA inhibits phorbol ester-mediated arachidonate release.
Topics: Animals; Arachidonic Acid; Blotting, Northern; Blotting, Southern; Blotting, Western; Cell Line; DNA; DNA, Antisense; Dogs; Isoenzymes; Kidney; Kinetics; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Cellular mechanisms for orthovanadate-, phorbol ester-, and calcium ionophore-stimulated prostaglandin production in brook trout (Salvelinus fontinalis) follicles.
Topics: Animals; Arachidonic Acid; Calcimycin; Cycloheximide; Dactinomycin; Female; Hydroxyeicosatetraenoic Acids; Ovarian Follicle; Prostaglandins; Tetradecanoylphorbol Acetate; Tritium; Trout; Vanadates | 1993 |
Attenuated prostaglandin formation in peroxisomal-deficient human skin fibroblasts.
Topics: Arachidonic Acid; Cells, Cultured; Dinoprostone; Fibroblasts; Gene Expression; Humans; Hydrogen Peroxide; In Vitro Techniques; Microbodies; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Refsum Disease; RNA, Messenger; Tetradecanoylphorbol Acetate; Zellweger Syndrome | 1993 |
Selection of alternative G-mediated signaling pathways at the dopamine D2 receptor by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Alkaloids; Animals; Arachidonic Acid; Calcimycin; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Diglycerides; Diterpenes; Dopamine D2 Receptor Antagonists; Ergolines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine D2; Recombinant Proteins; Salicylamides; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F beta cell line.
Topics: Aluminum; Animals; Arachidonic Acid; Calcium; Calcium-Binding Proteins; Cell Line; Colforsin; Cyclic AMP; Deferoxamine; Exocytosis; Extracellular Space; Insulin; Insulin Secretion; Ionomycin; Islets of Langerhans; Kinetics; Melitten; Nitrendipine; Potassium Chloride; Protein Kinase C; Secretory Rate; Sodium Fluoride; Stimulation, Chemical; Sulfonamides; Temperature; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Trifluoperazine | 1995 |
Alteration of lipid composition modulates Fc epsilon RI signaling in RBL-2H3 cells.
Topics: Antigens; Arachidonic Acid; Calcimycin; Cell Degranulation; Cell Line; Cell Membrane; Cholesterol; Dinitrophenols; Liposomes; Membrane Lipids; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Receptors, IgE; Serotonin; Serum Albumin, Bovine; Signal Transduction; Sonication; Sphingomyelins; Tetradecanoylphorbol Acetate; Tritium | 1995 |
[Functional features of monocytes from bronchial asthma patients: "respiratory burst" and lipid peroxidation].
Topics: Adult; Arachidonic Acid; Asthma; Calcium; Cell Membrane; Enzyme Activation; Humans; Lipid Peroxidation; Male; Middle Aged; Monocytes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Protein Kinase C; Respiratory Burst; Tetradecanoylphorbol Acetate | 1994 |
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.
Topics: Arachidonic Acid; Arachidonic Acids; Cell Movement; Chemotaxis, Leukocyte; Eosinophils; Glucuronidase; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Platelet Activating Factor; Tetradecanoylphorbol Acetate | 1995 |
Unusual carbachol responses in RINm5F cells: evidence for a "distal" site of action in stimulus-secretion coupling.
Topics: Arachidonic Acid; Calcium; Carbachol; Cells, Cultured; Guanosine Triphosphate; Insulin; Insulin Secretion; Membrane Potentials; Protein Kinase C; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Evidence for participation of vicinal dithiols in the activation sequence of the respiratory burst of human neutrophils.
Topics: Arachidonic Acid; Arsenicals; Blood Proteins; Calcium; Cell-Free System; Cytosol; Dimercaprol; Humans; Isoenzymes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Respiratory Burst; Signal Transduction; Sulfhydryl Compounds; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Leukotriene-deficient mice generated by targeted disruption of the 5-lipoxygenase gene.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Bone Marrow Cells; Carrageenan; Dinoprostone; Female; Inflammation; Leukotriene C4; Leukotrienes; Macrophages; Male; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Phagocytosis; Phenotype; Platelet Activating Factor; Spleen; Tetradecanoylphorbol Acetate | 1995 |
Regulation of leukotriene C4 synthase in human platelets via receptor-mediated mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Blood Platelets; Chromatography, High Pressure Liquid; Collagen; Epoprostenol; Glutathione Transferase; GTP-Binding Proteins; Humans; Kinetics; Leukotriene C4; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Thrombin; Receptors, Thromboxane; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Type C Phospholipases | 1995 |
Arachidonic acid liberation from rat tracheal epithelial cells by alveolar macrophages.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Bronchoalveolar Lavage Fluid; Calcimycin; Cells, Cultured; Culture Media, Conditioned; Epithelium; Inflammation; Macrophages, Alveolar; Rats; Tetradecanoylphorbol Acetate; Trachea | 1995 |
AA-release is under control of PLA2 and DAG lipase in rat liver macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cyclohexanones; Fluorides; Isoenzymes; Kinetics; Kupffer Cells; Lipoprotein Lipase; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Zymosan | 1995 |
Synergistic interaction of Y1-neuropeptide Y and alpha 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C, and arachidonic acid production.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Arachidonic Acid; Calcium; CHO Cells; Cricetinae; Drug Synergism; Enzyme Activation; Hydroquinones; Inositol 1,4,5-Trisphosphate; Peptide YY; Peptides; Pertussis Toxin; Phenylephrine; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoric Diester Hydrolases; Protein Kinase C; Receptors, Adrenergic, alpha-1; Receptors, Neuropeptide Y; Recombinant Fusion Proteins; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Virulence Factors, Bordetella | 1995 |
Down-regulation of protein kinase C attenuates the oxidant hydrogen peroxide-mediated activation of phospholipase A2 in pulmonary vascular smooth muscle cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Gallic Acid; Hydrogen Peroxide; Muscle, Smooth, Vascular; Oxidants; Phospholipases A; Phospholipases A2; Protein Kinase C; Pulmonary Artery; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Effect of lipoproteins on macrophage superoxide generation.
Topics: Animals; Arachidonic Acid; Calcimycin; Digitonin; Humans; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages, Peritoneal; Neutrophils; Rats; Sodium Fluoride; Superoxides; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Arachidonic acid-dependent phosphorylation of troponin I and myosin light chain 2 in cardiac myocytes.
Topics: Actin Cytoskeleton; Animals; Arachidonic Acid; Blotting, Western; Calcium; Endothelins; Enzyme Activation; Heart Ventricles; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Myocardium; Myofibrils; Myosins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rabbits; Rats; Tetradecanoylphorbol Acetate; Troponin; Troponin I | 1995 |
Cardioprotection in an in vitro model of hypoxic preconditioning.
Topics: Aerobiosis; Animals; Animals, Newborn; Arachidonic Acid; Cell Hypoxia; Cells, Cultured; Heart; Humans; Kinetics; Myocardial Ischemia; Myocardium; Rats; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
The fatty acid bimodal action on superoxide anion production by human adherent monocytes under phorbol 12-myristate 13-acetate or diacylglycerol activation can be explained by the modulation of protein kinase C and p47phox translocation.
Topics: Arachidonic Acid; Blood Proteins; Cell Adhesion; Diglycerides; Fatty Acids, Nonesterified; Humans; Indicators and Reagents; Kinetics; Leukocytes, Mononuclear; Myristic Acids; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; Phosphorylation; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Involvement of the alpha isoenzyme of protein kinase C in the growth inhibition induced by phorbol esters in MH1C1 hepatoma cells.
Topics: Alkaloids; Animals; Arachidonic Acid; Cell Division; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver Neoplasms, Experimental; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages.
Topics: Acylation; Animals; Arachidonic Acid; Biological Transport, Active; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; In Vitro Techniques; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Tetradecanoylphorbol Acetate | 1994 |
N-ethylmaleimide inhibits platelet aggregation and potentiates hydrogen peroxide formation induced by thrombin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Blood Platelets; Calcimycin; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Ethylmaleimide; Humans; Hydrogen Peroxide; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Vasoconstrictor Agents | 1994 |
N,N,N-trimethylsphingosine modifies aggregatory response and ATP release from platelets in whole blood.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Arachidonic Acid; Blood Platelets; Collagen; Humans; Platelet Aggregation; Protein Kinase C; Ristocetin; Sphingosine; Tetradecanoylphorbol Acetate | 1994 |
Activation of mitogen-activated protein kinase by arachidonic acid in rat liver epithelial WB cells by a protein kinase C-dependent mechanism.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Epithelial Cells; Epithelium; Fatty Acids, Unsaturated; Liver; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Tetradecanoylphorbol Acetate | 1995 |
The tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, inhibit the release of (3H)arachidonate from human platelets stimulated by thrombin or collagen.
Topics: Adenosine Triphosphate; Apyrase; Arachidonic Acid; Blood Platelets; Calcium; Cinnamates; Collagen; Enzyme Activation; Genistein; Humans; Indomethacin; Isoflavones; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin | 1994 |
Involvement of protein kinase C and arachidonate signaling pathways in the alteration of proliferative response of senescent IMR-90 human fibroblasts.
Topics: Arachidonic Acid; Cell Division; Cell Line; Cellular Senescence; Diglycerides; DNA; Enzyme Activation; Fibroblasts; Humans; Indomethacin; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine | 1994 |
The arachidonate-activable, NADPH oxidase-associated H+ channel. Evidence that gp91-phox functions as an essential part of the channel.
Topics: Animals; Arachidonic Acid; B-Lymphocytes; Base Sequence; Cell Differentiation; Cell Line; Cell Line, Transformed; CHO Cells; Cricetinae; DNA, Complementary; Herpesvirus 4, Human; Humans; Hydrogen-Ion Concentration; Hygromycin B; Kinetics; Leukemia, Promyelocytic, Acute; Membrane Glycoproteins; Membrane Transport Proteins; Models, Biological; Molecular Sequence Data; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Phosphoproteins; Plasmids; Proton Pumps; Recombinant Proteins; Restriction Mapping; Superoxides; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
The role of protein kinase C in alpha-adrenergic regulation of NaCl(K) cotransport in human airway epithelial cells.
Topics: Alkaloids; Arachidonic Acid; Carrier Proteins; Chlorides; Cystic Fibrosis; Diglycerides; Epinephrine; Epithelium; Humans; Isoproterenol; Methoxamine; Nasal Polyps; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoproteins; Protein Kinase C; Receptors, Adrenergic, alpha; Sodium Chloride Symporters; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1995 |
Factor XIIIa binding to activated platelets is mediated through activation of glycoprotein IIb-IIIa.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Arachidonic Acid; Blood Platelets; Calcimycin; Collagen; Epinephrine; Fibrinogen; Fibronectins; Flow Cytometry; Humans; In Vitro Techniques; Kinetics; Membrane Glycoproteins; Membrane Proteins; Oligopeptides; Platelet Activation; Platelet Membrane Glycoproteins; Reference Values; Tetradecanoylphorbol Acetate; Thrombasthenia; Thrombin; Thrombospondins; Time Factors; Transglutaminases | 1994 |
Synthesis and topical antiinflammatory and antiallergic activities of antioxidant o-aminophenol derivatives.
Topics: Administration, Topical; Aminophenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonic Acid; Brain; Ear; Edema; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Delayed; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Rats; Rats, Sprague-Dawley; Skin Tests; Tetradecanoylphorbol Acetate | 1994 |
Release and steroidogenic actions of polyunsaturated fatty acids in the goldfish testis.
Topics: Animals; Arachidonic Acid; Calcimycin; Dinoprostone; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Goldfish; Indomethacin; Male; Prostaglandins E; Testis; Testosterone; Tetradecanoylphorbol Acetate | 1994 |
Modulation of rat peripheral polymorphonuclear leukocyte response by nitric oxide and arginine.
Topics: Animals; Arachidonic Acid; Arginine; Free Radicals; Hydroxyl Radical; Luminescent Measurements; Luminol; Male; Malondialdehyde; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity.
Topics: Administration, Topical; Anti-Inflammatory Agents; Arachidonic Acid; Dermatitis; Eicosanoids; Humans; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tretinoin | 1994 |
Modulation of phorbol ester-induced contraction by endogenously released cyclooxygenase products in rat aorta.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Epoprostenol; Fatty Acids, Unsaturated; Hydrazines; In Vitro Techniques; Indomethacin; Kinetics; Male; Models, Cardiovascular; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins, Synthetic; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thromboxane A2; Time Factors | 1994 |
The role of protein kinase C in arachidonic acid release and prostaglandin E production from CHO cells transfected with EGF receptors.
Topics: Alkaloids; Animals; Arachidonic Acid; CHO Cells; Cricetinae; Epidermal Growth Factor; ErbB Receptors; Phospholipases A; Phospholipases A2; Prostaglandins E; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis.
Topics: Animals; Arachidonic Acid; Becaplermin; Binding, Competitive; Cells, Cultured; Diglycerides; DNA; Enzyme Activation; Gene Expression; Kinetics; Mitogens; Muscle, Smooth, Vascular; Myristic Acid; Myristic Acids; Platelet-Derived Growth Factor; Protein Biosynthesis; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rats; Rats, Inbred SHR; Receptors, Platelet-Derived Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1994 |
Regulation of cytosolic phospholipase A2 phosphorylation and eicosanoid production by colony-stimulating factor 1.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cytosol; Drug Synergism; Eicosanoids; Enzyme Activation; Macrophage Colony-Stimulating Factor; Macrophages, Peritoneal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
1,3-Dioctanoylglycerol (1,3-DiC8) is as effective as 1,2-dioctanoylglycerol (1,2-DiC8) in priming phospholipase A2 activation in human platelets and neutrophils.
Topics: Arachidonic Acid; Blood Platelets; Calcimycin; Diglycerides; Enzyme Activation; Humans; Neutrophils; Phospholipases A; Phospholipases A1; Phospholipases A2; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Activation of arachidonic acid metabolism in mouse macrophages by bacterial amphiphiles.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Chromatography; Eicosanoids; Gram-Positive Bacteria; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Salmonella; Sepharose; Streptomyces; Teichoic Acids; Tetradecanoylphorbol Acetate | 1994 |
Avarol and avarone, two new anti-inflammatory agents of marine origin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclohexenes; Edema; Indomethacin; Inflammation; Leukocytes; Male; Mice; Peritoneum; Phospholipases A; Phospholipases A2; Rats; Sesquiterpenes; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C-dependent and -independent pathways of mitogen-activated protein kinase activation in macrophages by stimuli that activate phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Macrophages, Peritoneal; Maleimides; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Tetradecanoylphorbol Acetate; Tyrosine; Zymosan | 1994 |
Studies with transfected and permeabilized RBL-2H3 cells reveal unique inhibitory properties of protein kinase C gamma.
Topics: Animals; Arachidonic Acid; beta-N-Acetylhexosaminidases; Calcium; Cell Line; Cell Membrane; Cell Membrane Permeability; Dinitrophenols; DNA, Complementary; Exocytosis; Hydrolysis; Isoenzymes; Mast Cells; Moloney murine leukemia virus; Phosphatidylinositols; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Rats; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Transfection | 1994 |
A Chinese hamster fibroblast mutant defective in thrombin-induced signaling has a low level of phospholipase C-beta 1.
Topics: Animals; Arachidonic Acid; Biological Transport; Cell Compartmentation; Cricetinae; Cricetulus; Down-Regulation; Fibroblasts; Isoenzymes; Mutation; Phosphatidylinositols; Phospholipase C beta; Phospholipases A; Signal Transduction; Sodium-Hydrogen Exchangers; Substrate Specificity; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1994 |
Cortisol inhibition of growth hormone-releasing hormone-stimulated growth hormone release from cultured sheep pituitary cells.
Topics: Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cells, Cultured; Colforsin; Depression, Chemical; Growth Hormone; Growth Hormone-Releasing Hormone; Hydrocortisone; Male; Pertussis Toxin; Pituitary Gland; Potassium Chloride; Puromycin; Sheep; Tetradecanoylphorbol Acetate; Time Factors; Virulence Factors, Bordetella | 1994 |
Separation of agonist-stimulated arachidonate mobilization from subsequent leukotriene B4 synthesis in human neutrophils: different effects of oleoylacetylglycerol and phorbol myristate acetate as priming agents.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Arachidonic Acid; Biological Transport; Calcimycin; Diglycerides; Eicosanoids; Fatty Acids; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Leukotriene Antagonists; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Tetradecanoylphorbol Acetate | 1994 |
Complement activation and neutrophil aggregation changes during haemodialysis.
Topics: Acrylic Resins; Adult; Arachidonic Acid; Calcimycin; Cell Aggregation; Cellulose; Complement Activation; Humans; Kidney Failure, Chronic; Membranes, Artificial; Middle Aged; Neutrophils; Renal Dialysis; Tetradecanoylphorbol Acetate; Thromboxane A2; Thromboxane B2 | 1993 |
Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adrenal Glands; Aging; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Cytosol; Guanylate Cyclase; Isoproterenol; Kinetics; Mice; Norepinephrine; Organ Culture Techniques; Phospholipases A; Phospholipases A2; Pineal Gland; Potassium; Protein Kinases; Rats; Tetradecanoylphorbol Acetate | 1993 |
Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes.
Topics: Actins; Animals; Arachidonic Acid; Blotting, Northern; Cell Nucleus; Cycloheximide; Ethanol; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Hydroxyeicosatetraenoic Acids; Leukotrienes; Lipid Peroxides; Lymphoma; Masoprocol; Mice; RNA, Messenger; RNA, Neoplasm; Stearoyl-CoA Desaturase; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Bradykinin; Calcium; Calcium-Transporting ATPases; Cytosol; DNA; Egtazic Acid; Inositol; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Kinetics; Lysophospholipids; Mice; Phorbol Esters; Second Messenger Systems; Sphingosine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Time Factors | 1994 |
Effects of CGRP in different models of mouse ear inflammation.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Calcitonin Gene-Related Peptide; Cantharidin; Capsaicin; Croton Oil; Disease Models, Animal; Dose-Response Relationship, Drug; Ear; Inflammation; Male; Mice; Tetradecanoylphorbol Acetate | 1994 |
Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation.
Topics: Acetylglucosaminidase; Animals; Arachidonic Acid; Capillary Permeability; Cyclooxygenase Inhibitors; Dermatitis, Contact; Disease Models, Animal; Edema; Eicosanoids; Female; Leukotriene Antagonists; Lipoxygenase Inhibitors; Lymphocytes; Male; Mast Cells; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Tetradecanoylphorbol Acetate | 1993 |
Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Homosteroids; Humans; Leukotrienes; Male; Mice; Mice, Inbred BALB C; Neutrophils; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Sesterterpenes; Terpenes; Tetradecanoylphorbol Acetate | 1994 |
In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids.
Topics: Animals; Arachidonic Acid; Brain; Docosahexaenoic Acids; Eicosapentaenoic Acid; Enzyme Activation; Fatty Acids; Fatty Acids, Unsaturated; Humans; Male; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1994 |
The presence of cytoplasmic lipid droplets is not sufficient to account for neutral lipid signals in the 1H MR spectra of neutrophils.
Topics: Arachidonic Acid; Cell Membrane; Cytoplasm; Humans; Hydrogen; Inclusion Bodies; Lipid Metabolism; Lipopolysaccharides; Magnetic Resonance Spectroscopy; Neutrophils; Oleic Acid; Oleic Acids; Salmonella typhimurium; Tetradecanoylphorbol Acetate | 1994 |
Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; Arachidonic Acid; Binding Sites; Calcium; Colforsin; Enzyme Activation; HeLa Cells; Humans; Ligands; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Receptors, Serotonin; Serotonin; Tetradecanoylphorbol Acetate | 1994 |
Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes.
Topics: Arachidonic Acid; Arachidonic Acids; Chemotactic Factors; Chemotaxis, Leukocyte; Humans; Hydroxyeicosatetraenoic Acids; Neutrophils; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Dogs; Enzyme Activation; Glycerophospholipids; Kidney; Neomycin; Nucleotides; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Interactions of bradykinin, calcium, G-protein and protein kinase in the activation of phospholipase A2 in bovine pulmonary artery endothelial cells.
Topics: Animals; Arachidonic Acid; Bradykinin; Calcium; Cattle; Cytosol; Endothelium, Vascular; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ion-Selective Electrodes; Pertussis Toxin; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinases; Pulmonary Artery; Saponins; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Arachidonic acid liberation induced by phosphatidic acid endogenously generated from membrane phospholipids in rabbit platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Ethanol; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Lipids; Phosphatidic Acids; Phospholipase D; Phospholipases A; Phospholipases A2; Phospholipids; Rabbits; Tetradecanoylphorbol Acetate | 1994 |
[The effect of alpha-tocopherol over a wide range of concentrations (10(-2)-10(-17) M) on protein kinase C activity. Connection with proliferation and tumor growth].
Topics: Animals; Arachidonic Acid; Cell Division; Enzyme Activation; Lipid Peroxides; Myocardium; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vitamin E | 1994 |
Phospholipases and melatonin signal transduction in the ovine pars tuberalis.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Choline; Colforsin; Cyclic AMP; Female; Lysophospholipids; Male; Melatonin; Membrane Lipids; Phosphatidic Acids; Phospholipases; Phospholipids; Pituitary Gland, Anterior; Second Messenger Systems; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Inhibition of NADPH-oxidase activity in human polymorphonuclear neutrophils by lipophilic ascorbic acid derivatives.
Topics: Amino Acid Sequence; Arachidonic Acid; Ascorbic Acid; Calcium; Guanine Nucleotides; Humans; In Vitro Techniques; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Interactions between protein kinase C and arachidonic acid in the gonadotropin response to salmon and chicken gonadotropin-releasing hormone-II in goldfish.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Cells, Cultured; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Isoquinolines; Lipoprotein Lipase; Masoprocol; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Arachidonic Acid; Base Sequence; Cell Line; Cells, Cultured; Dinoprostone; Embryo, Mammalian; Fibroblasts; Gene Expression; Immune Sera; Lipopolysaccharides; Macrophages; Mice; Molecular Sequence Data; Oligonucleotides, Antisense; Peptides; Platelet-Derived Growth Factor; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Evidence that v-Src-induced phospholipase D activity is mediated by a G protein.
Topics: 3T3 Cells; Adenine Nucleotides; Aluminum Compounds; Animals; Arachidonic Acid; Avian Sarcoma Viruses; Benzoquinones; Cell Line, Transformed; Cholera Toxin; Enzyme Induction; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Kinetics; Lactams, Macrocyclic; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Oncogene Protein pp60(v-src); Phosphatidylcholines; Phospholipase D; Protein-Tyrosine Kinases; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1994 |
A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.
Topics: 3T3 Cells; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acid; Cell Division; Cell Nucleus; Cholera Toxin; Colforsin; Cyclic AMP; Dinoprostone; DNA; Drug Synergism; Epidermal Growth Factor; Kinetics; Lysophospholipids; Mice; Mitogens; Phosphatidic Acids; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine | 1994 |
Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carrageenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Chromans; Cyclooxygenase Inhibitors; Ear, External; Edema; Extracellular Space; Female; In Vitro Techniques; Inflammation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Phenols; Phospholipases A; Phospholipases A2; Pleurisy; Rabbits; Rats; Rats, Wistar; Sheep; Tetradecanoylphorbol Acetate | 1993 |
A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages.
Topics: Alkaloids; Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Eicosanoids; Fatty Acids; Isoenzymes; Kinetics; Leukotriene C4; Macrophages, Peritoneal; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Enzyme Activation; Ethers, Cyclic; Macrophages; Mice; Molecular Sequence Data; Okadaic Acid; Peptide Mapping; Peritoneal Cavity; Phospholipases A; Phospholipases A2; Phosphorylation; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia.
Topics: Alkaloids; Animals; Arachidonic Acid; Carbon Monoxide; Endotoxins; Fatty Acids, Nonesterified; Kupffer Cells; Lipoxygenase Inhibitors; Liver; Male; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1993 |
Enhancement of A23187-induced arachidonic acid liberation by vasopressin is sensitive to genistein in rabbit platelets.
Topics: Acetophenones; Adenosine Triphosphate; Alkaloids; Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Synergism; Epinephrine; Genistein; Isoflavones; Phospholipases A; Phospholipases A2; Platelet Aggregation; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Adhesive interactions of neutrophils and leukotriene synthesis.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Adhesion; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukotriene B4; Neutrophils; Tetradecanoylphorbol Acetate | 1993 |
The mechanism of bradykinin-induced arachidonic acid release in osteoblast-like MC3T3-E1 cells phospholipase A2 activation by bradykinin and its regulation by protein kinase C and calcium.
Topics: 3T3 Cells; Alkaloids; Animals; Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Down-Regulation; Mice; Osteoblasts; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinacrine; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Exogenous arachidonic acid inactivates protein kinase C in mouse pancreatic islets.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane; Cytosol; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mice; Mice, Inbred Strains; Phosphatidylserines; Phosphorylation; Protein Kinase C; Serum Albumin; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Formation of diacylglycerol, inositol phosphates, arachidonic acid and its metabolites in macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Cyclohexanones; Diglycerides; Fluorides; Inositol Phosphates; Macrophages; Male; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Zymosan | 1993 |
Leukotriene B4 and C4 production in isolated rat gastric mucosal cells.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Bucladesine; Calcimycin; Cell Separation; Colforsin; Diglycerides; Female; Gastric Mucosa; Histamine; In Vitro Techniques; Interleukin-1; Interleukin-2; Kinetics; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Pentagastrin; Phenothiazines; Platelet Activating Factor; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1993 |
The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils.
Topics: Acetophenones; Alkaloids; Arachidonic Acid; Biological Transport; Cell Membrane; Enzyme Activation; Humans; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Opsonin Proteins; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Quinacrine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Tritium; Zymosan | 1994 |
Diradylglycerols stimulate phospholipase A2 and subsequent exocytosis in ram spermatozoa. Evidence that the effect is not mediated via protein kinase C.
Topics: Acrosome; Animals; Arachidonic Acid; Calcimycin; Calcium; Diglycerides; Enzyme Activation; Exocytosis; Glycerides; Male; Phorbol 12,13-Dibutyrate; Phospholipases A; Phospholipases A2; Protein Kinase C; Sheep; Spermatozoa; Tetradecanoylphorbol Acetate | 1994 |
Activation and desensitization of phospholipase D in intact rat hepatocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Diglycerides; Enzyme Activation; Ethanol; Glycerophospholipids; Liver; Male; Phosphatidic Acids; Phospholipase D; Rats; Rats, Sprague-Dawley; Stearic Acids; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1994 |
Reduced phospholipase A2 activity is not accompanied by reduced arachidonic acid release.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Blotting, Western; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Gene Expression; Genetic Vectors; Kinetics; Mice; Phospholipases A; Phospholipases A2; Platelet-Derived Growth Factor; RNA, Antisense; Tetradecanoylphorbol Acetate; Transfection | 1994 |
Expression of a mutant Gi2 alpha subunit inhibits ATP and thrombin stimulation of cytoplasmic phospholipase A2-mediated arachidonic acid release independent of Ca2+ and mitogen-activated protein kinase regulation.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Arachidonic Acid; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cholera Toxin; Clone Cells; Cricetinae; Cyclic AMP; Cytoplasm; Enzyme Activation; Gene Expression; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phospholipases A; Phospholipases A2; Phospholipids; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Transfection | 1994 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Activation; Humans; Male; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin; Tyrosine | 1994 |
Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2.
Topics: Adenosine Triphosphate; Aluminum Compounds; Arachidonic Acid; Blotting, Western; Bucladesine; Calcimycin; Calcium; Cell Differentiation; Cell Line; Cytosol; Electrophoresis, Polyacrylamide Gel; Fluorides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Differential roles for triglyceride and phospholipid pools of arachidonic acid in human lung macrophages.
Topics: Arachidonic Acid; Calcimycin; Eicosanoids; Humans; In Vitro Techniques; Macrophage Activation; Macrophages, Alveolar; Phospholipases; Phospholipids; Tetradecanoylphorbol Acetate; Triglycerides | 1994 |
Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate.
Topics: Alkaloids; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Enzyme Inhibitors; Ethers, Cyclic; Genistein; In Vitro Techniques; Isoflavones; Kupffer Cells; Lipopolysaccharides; Male; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Vanadates | 1994 |
Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abietanes; Animals; Anticarcinogenic Agents; Antioxidants; Arachidonic Acid; Benzo(a)pyrene; Dermatitis, Contact; DNA; Drug Interactions; Enzyme Induction; Epidermis; Female; Hyperplasia; Magnoliopsida; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phenanthrenes; Plant Extracts; Skin; Skin Neoplasms; Spices; Tetradecanoylphorbol Acetate; Triterpenes; Tritium; Ursolic Acid | 1994 |
Modulation of phorbol ester-associated events in epidermal cells by linoleate and arachidonate.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Dinoprostone; Epidermis; Kinetics; Linoleic Acid; Linoleic Acids; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Protein Kinase C; Tetradecanoylphorbol Acetate | 1993 |
Effects of phorbol ester on gap junctions of neonatal rat heart cells.
Topics: Alkaloids; Animals; Animals, Newborn; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Diglycerides; Electric Conductivity; Heart Ventricles; Intercellular Junctions; Kinetics; Myocardium; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Modulation by protein kinase C of arachidonic acid release from permeabilised myometrial cells of guinea pig uterus.
Topics: Alkaloids; Animals; Arachidonic Acid; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Activation; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Inositol Phosphates; Myometrium; Phospholipases A; Phospholipases A2; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1993 |
Stimulation of cultured amnion cell prostaglandin endoperoxide H synthase activity by glucocorticoids and phorbol ester.
Topics: Amnion; Analysis of Variance; Arachidonic Acid; Cells, Cultured; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Regression Analysis; Tetradecanoylphorbol Acetate | 1993 |
Interleukin-1 selectively potentiates bradykinin-stimulated arachidonic acid release from human synovial fibroblasts.
Topics: Arachidonic Acid; Bradykinin; Calcium; Cells, Cultured; Cyclohexanones; Cycloheximide; Cytosol; Dactinomycin; Drug Synergism; Fibroblasts; Humans; Interleukin-1; Kinetics; Protein Kinase C; Stearic Acids; Synovial Membrane; Tetradecanoylphorbol Acetate; Tritium; Type C Phospholipases | 1993 |
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation.
Topics: Alkaloids; Amino Alcohols; Arachidonic Acid; Enzyme Activation; Humans; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Onium Compounds; Phosphoproteins; Phosphorylation; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Induction of superoxide by 12-O-tetradecanoylphorbol-13-acetate and thapsigargin, a non-phorbol-ester-type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: a permissive role for the arachidonic acid cascade in signal transdu
Topics: Analysis of Variance; Animals; Arachidonic Acid; Carcinogens; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Female; Macrophages; Mice; Phosphorylation; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Species Specificity; Specific Pathogen-Free Organisms; Superoxides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Different roles of protein kinase C-beta and -delta in arachidonic acid cascade, superoxide formation and phosphoinositide hydrolysis.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Hydrolysis; Isoenzymes; Liver; Macrophages; Male; Phorbol Esters; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Human neutrophil adhesion to bovine aortic endothelium. Evidence for endothelial lipoxygenase activity.
Topics: Animals; Arachidonic Acid; Cattle; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Humans; Inflammation; Leukotriene B4; Lipoxygenase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Tetradecanoylphorbol Acetate; Thrombin | 1993 |
Interferon-gamma-stimulated and GTP-binding-proteins-mediated phospholipase A2 activation in human neuroblasts.
Topics: Arachidonic Acid; Calcium; Enzyme Activation; GTP-Binding Proteins; Humans; Interferon gamma Receptor; Interferon-gamma; Neomycin; Neurons; Nucleotides; Pertussis Toxin; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Interferon; Recombinant Proteins; Tetradecanoylphorbol Acetate; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Phorbol ester TPA- and bradykinin-induced arachidonic acid release from keratinocytes is catalyzed by a cytosolic phospholipase A2 (cPLA2).
Topics: Animals; Arachidonic Acid; Biological Transport; Bradykinin; Calcium; Catalysis; Cell Line; Cell Membrane; Cytosol; Keratinocytes; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate | 1993 |
Antirheumatic gold compounds and penicillamine enhance protein kinase C-mediated activation of the arachidonate-mobilizing phospholipase A2 in mouse macrophages.
Topics: Animals; Arachidonic Acid; Auranofin; Aurothioglucose; Calcimycin; Eicosanoids; Enzyme Activation; Gold Sodium Thiomalate; Kinetics; Macrophages, Peritoneal; Mice; Molecular Weight; Penicillamine; Phospholipases A; Phospholipases A2; Phosphoproteins; Protein Kinases; Tetradecanoylphorbol Acetate | 1993 |
Characteristics of arachidonic-acid-mediated brain protein kinase C activation: evidence for concentration-dependent heterogeneity.
Topics: Animals; Arachidonic Acid; Binding Sites; Brain Chemistry; Deoxycholic Acid; Dose-Response Relationship, Drug; Enzyme Activation; Male; Phosphatidylcholines; Phosphatidylserines; Protein Kinase C; Rats; Signal Transduction; Substrate Specificity; Tetradecanoylphorbol Acetate | 1993 |
Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Cell Adhesion; Cell Division; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Leukemia, Erythroblastic, Acute; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Endothelins release 51Cr from cultured human cerebromicrovascular endothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Chromium Radioisotopes; Dexamethasone; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; L-Lactate Dehydrogenase; Microcirculation; Piperazines; Protein Kinase Inhibitors; Ryanodine; Tetradecanoylphorbol Acetate; Verapamil | 1993 |
Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by Fc gamma Rs in human neutrophils.
Topics: Arachidonic Acid; Calcium; Enzyme Activation; Erythrocytes; Humans; Immunoglobulin G; In Vitro Techniques; Inositol Phosphates; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Phagocytosis; Phospholipids; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate | 1993 |
Tumor necrosis factor-alpha potentiates phospholipase A2-stimulated release and metabolism of arachidonic acid in cultured intestinal epithelial cells (INT 407).
Topics: Arachidonic Acid; Calcimycin; Cell Line; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Epithelium; Humans; Intestinal Mucosa; Lipid Metabolism; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1993 |
Effects of specific fatty acids on prolactin-induced NB2 lymphoma cell proliferation.
Topics: Animals; Arachidonic Acid; Cell Division; Cell Line; Dose-Response Relationship, Drug; Fatty Acids; Gossypol; Kinetics; Lymphoma; Membrane Lipids; Prolactin; Protein Kinase C; Quercetin; Rats; Stearic Acids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential regulation of phospholipase D and phospholipase C by protein kinase C-beta and -delta in liver macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Carcinogens; Enzyme Activation; Fluorides; Inositol Phosphates; Ionophores; Isoenzymes; Liver; Macrophages; Male; Phospholipase D; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Type C Phospholipases; Zymosan | 1995 |
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.
Topics: Animals; Arachidonic Acid; Bacteriophage lambda; Base Sequence; Dinoprostone; Female; Genetic Vectors; Genotype; Homozygote; Kidney; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mortality; Otitis Externa; Peritoneum; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1995 |
Differential involvement of protein kinase C in activating cytosolic phospholipase A2 in alveolar macrophages and monocyte differentiated U937 cells.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Differentiation; Cell Line; Cytosol; Enzyme Activation; Guinea Pigs; Macrophages, Alveolar; Monocytes; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
The mechanism of sphingosine enhancement of phorbol ester-mediated phospholipase D activation in lymphocytes.
Topics: Animals; Arachidonic Acid; Biological Transport; Cattle; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycerophospholipids; Lymphocyte Activation; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1995 |
Regulation of the serum-activated Ca(2+)-dependent chloride channel in Xenopus oocytes.
Topics: Animals; Arachidonic Acid; Blood; Calcium; Calcium Channels; Cattle; Chloride Channels; Chlorides; Female; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Oocytes; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Xenopus laevis | 1996 |
Lipid changes in HL-60 cells on differentiation into macrophages by treatment with a phorbol ester.
Topics: Arachidonic Acid; Carcinogens; Cell Differentiation; Cholesterol; Ethanolamines; HL-60 Cells; Humans; Lipid Metabolism; Macrophages; Phospholipids; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Triglycerides; Tumor Cells, Cultured | 1995 |
Amplification of arachidonic acid metabolism in rat liver cells (the C-9 cell-line) by tosyl-L-phenylalanine chloromethyl ketone and phenylmethyl-sulfonyl fluoride.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Line; Diglycerides; Epoprostenol; Indomethacin; Liver; Lyngbya Toxins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rats; Serine Proteinase Inhibitors; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone | 1995 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Short-term and long-term-effects of phorbol 12-myristate 13-acetate and different inhibitors on the ability of bone marrow cells to form colonies in vitro.
Topics: Animals; Arachidonic Acid; Bone Marrow; Bone Marrow Cells; Calcimycin; Enzyme Inhibitors; Growth Inhibitors; Hematopoietic Stem Cells; Ionophores; Lysophosphatidylcholines; Mice; Mice, Inbred CBA; Phospholipases A; Phospholipases A2; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Inhibition of collagen-induced platelet activation by arachidonyl trifluoromethyl ketone.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Collagen; Enzyme Inhibitors; Humans; Phospholipases A; Phospholipases A2; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1995 |
Characterisation of cytosolic phospholipase A2 as mediator of the enhanced arachidonic acid release from dimethyl sulphoxide differentiated U937 cells.
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Differentiation; Cell Membrane; Cytosol; Dimethyl Sulfoxide; Enzyme Activation; Heparin; Humans; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: involvement of protein tyrosine kinase and protein kinase C.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Genistein; Hepatocyte Growth Factor; Isoflavones; Liver; Male; Mitogen-Activated Protein Kinase Kinases; Phospholipases A; Phospholipases A2; Prostaglandins; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Quinacrine; ras Proteins; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1996 |
Modulation of the stress-induced synthesis of stress proteins by a phorbol ester and okadaic acid.
Topics: Alkaloids; Animals; Arachidonic Acid; Arsenites; Blotting, Northern; Blotting, Western; Enzyme Activation; Ethers, Cyclic; Glioma; Heat-Shock Proteins; Okadaic Acid; Protein Kinase C; Rats; RNA, Messenger; Serine Proteinase Inhibitors; Staurosporine; Stimulation, Chemical; Stress, Physiological; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Stimulation of arachidonic acid mobilization by adherence of resident peritoneal macrophages to plastic substrate.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cattle; Cell Adhesion; Cells, Cultured; Enzyme Inhibitors; Fetal Blood; Kinetics; Macrophages, Peritoneal; Male; Mice; Phospholipases A; Phospholipases A2; Plastics; Tetradecanoylphorbol Acetate | 1996 |
Microtubule-active agents mimic lipopolysaccharides in priming macrophages for enhanced arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Colchicine; Female; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Microtubules; Nocodazole; Paclitaxel; Tetradecanoylphorbol Acetate; Zymosan | 1996 |
Oxatomide and derivatives as inhibitors of mediator release from a mast cell model. Structure-activity relationships.
Topics: Animals; Anti-Allergic Agents; Arachidonic Acid; beta-N-Acetylhexosaminidases; Calcimycin; Cells, Cultured; Exocytosis; Histamine H1 Antagonists; Histamine Release; Ionophores; L-Lactate Dehydrogenase; Mast Cells; Piperazines; Rats; Signal Transduction; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1996 |
Endothelin-1 increases arachidonic acid release in C6 glioma cells through a potassium-modulated influx of calcium.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Endothelins; Enzyme Activation; Glioma; Ion Channel Gating; Ionophores; Phospholipases A; Phospholipases A2; Potassium; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Valinomycin | 1996 |
Proliferation-dependent changes in arachidonic acid mobilization from phospholipids of 3T6 fibroblasts.
Topics: Animals; Arachidonic Acid; Bradykinin; Calcimycin; Cell Division; Cell Line; Culture Media; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phospholipids; Phosphoric Monoester Hydrolases; Tetradecanoylphorbol Acetate | 1996 |
Evidence for the involvement of 5-lipoxygenase products in the regulation of the expression of the proenkephalin gene in cultured astroglial cells.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Astrocytes; Basal Metabolism; Cells, Cultured; Cyclooxygenase Inhibitors; Enkephalins; Gene Expression Regulation; Indomethacin; Leukotriene E4; Protein Precursors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1995 |
Role of protein kinase C alpha in nerve growth factor-induced arachidonic acid release from PC12 cells.
Topics: Animals; Arachidonic Acid; Enzyme Activation; Isoenzymes; Nerve Growth Factors; PC12 Cells; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1996 |
Modification of cultured Madin-Darby canine kidney cells with dietary unsaturated fatty acids and regulation of arachidonate cascade reaction.
Topics: Animals; Arachidonic Acid; Blotting, Western; Calcimycin; Cell Division; Cell Line; Cell Survival; Culture Media; Dinoprostone; Dogs; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Fatty Acids, Unsaturated; Ionophores; Kidney; Phospholipids; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1996 |
Regulation of arachidonic acid metabolism, aromatase activity and growth in human breast cancer cells by interleukin-1beta and phorbol ester: dissociation of a mediatory role for prostaglandin E2 in the autocrine control of cell function.
Topics: Arachidonic Acid; Aromatase; Breast Neoplasms; Cell Division; Dexamethasone; Dinoprostone; Enzyme Induction; Humans; Indomethacin; Interleukin-1; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Fish Oils; Macrophage Activation; Macrophages, Peritoneal; Male; Opsonin Proteins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Triglycerides; Zymosan | 1996 |
Regulation of intracellular pH by phospholipase A2 and protein kinase C upon neutrophil adhesion to solid substrata.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Albumins; Arachidonic Acid; Cell Adhesion; Fibronectins; Humans; Hydrogen-Ion Concentration; Lysophosphatidylcholines; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Interactions between signaling pathways in mediating GnRH-stimulated GTH release from goldfish pituitary cells: protein kinase C, but not cyclic AMP is an important mediator of GnRH-stimulated gonadotropin secretion in goldfish.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Arachidonic Acid; Calcium Channel Agonists; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Male; Microspheres; Naphthalenes; Pituitary Gland; Potassium; Protein Kinase C; Salmon; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fc gamma receptor activation: study of the signaling mechanism.
Topics: Animals; Antigen-Antibody Complex; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Base Sequence; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Intercellular Signaling Peptides and Proteins; Macrophages, Peritoneal; Male; Molecular Sequence Data; Phosphorylation; Rats; Rats, Wistar; Receptors, IgG; RNA, Messenger; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Inhibition by hydroxyachillin, sesquiterpene lactone from Tanacetum microphyllum, of PMA-induced mouse ear oedema.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capillary Permeability; Carcinogens; Dose-Response Relationship, Drug; Ear; Edema; Eicosanoids; Enzyme Activation; Female; Lactones; Lethal Dose 50; Mice; Phospholipases A; Phospholipases A2; Protein Kinase C; Reference Standards; Regression Analysis; Sesquiterpenes; Tetradecanoylphorbol Acetate | 1996 |
Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent.
Topics: Administration, Topical; Animals; Anthralin; Anti-Inflammatory Agents; Antifungal Agents; Arachidonic Acid; Carrageenan; Clotrimazole; Cyclooxygenase Inhibitors; Diclofenac; Edema; Granulocytes; Humans; Ketoconazole; Leukotriene B4; Male; Mice; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Regulation of tight junction resistance in T84 monolayers by elevation in intracellular Ca2+: a protein kinase C effect.
Topics: Arachidonic Acid; Calcimycin; Calcium; Cell Membrane Permeability; Chelating Agents; Egtazic Acid; Humans; Ionophores; Mannitol; Phospholipases; Protein Kinase C; Quinacrine; Tetradecanoylphorbol Acetate; Tight Junctions; Tumor Cells, Cultured | 1996 |
Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls.
Topics: Animals; Arachidonic Acid; Aroclors; Aspirin; Cyclooxygenase Inhibitors; Hydroxyurea; In Vitro Techniques; Lipoxygenase Inhibitors; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phospholipases A; Phospholipases A2; Polychlorinated Biphenyls; Quinacrine; Rats; Superoxides; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
Protein kinase C activation inhibits stress-induced synthesis of heat shock protein 27 in osteoblast-like cells: function of arachidonic acid.
Topics: 3T3 Cells; Animals; Arachidonic Acid; Arsenites; Choline; Cyclic AMP; Enzyme Activation; Heat-Shock Proteins; Indomethacin; Inositol Phosphates; Masoprocol; Melitten; Mice; Osteoblasts; Phosphatidylcholines; Protein Kinase C; Stress, Physiological; Tetradecanoylphorbol Acetate | 1996 |
Cord blood neutrophil responses to polyunsaturated fatty acids: effects on degranulation and oxidative respiratory burst.
Topics: Adult; Arachidonic Acid; Cytoplasmic Granules; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Fetal Blood; Humans; Infant, Newborn; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Respiratory Burst; Tetradecanoylphorbol Acetate | 1996 |
Ionomycin-stimulated arachidonic acid release in human platelets: a role for protein kinase C and tyrosine phosphorylation.
Topics: Arachidonic Acid; Blood Platelets; Calcium; Collagen; Enzyme Inhibitors; Genistein; Humans; Indoles; Ionomycin; Ionophores; Isoflavones; Phosphorylation; Protein Kinase C; Protein-Tyrosine Kinases; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
Phosphorylation of myeloid-related proteins MRP-14 and MRP-8 during human neutrophil activation.
Topics: Antigens, Differentiation; Arachidonic Acid; Calcimycin; Calcium; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Membrane; Cytochalasin B; Cytoplasm; Electrophoresis, Gel, Two-Dimensional; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Contribution of phosphoinositides and phosphatidylcholines to the production of phosphatidic acid upon concanavalin A stimulation of rat thymocytes.
Topics: Animals; Arachidonic Acid; Concanavalin A; Diglycerides; Hydrolysis; Male; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylinositols; Phospholipase D; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thymus Gland; Tritium; Type C Phospholipases | 1996 |
Arachidonic acid increases activation of NADPH oxidase in monocytic U937 cells by accelerated translocation of p47-phox and co-stimulation of protein kinase C.
Topics: Arachidonic Acid; Humans; Monocytes; NADPH Oxidases; Oxides; Phospholipases A; Phosphoproteins; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Lung cancer cell lines inhibit leukotriene B4 production by human polymorphonuclear leukocytes at the level of phospholipase A2.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Calcimycin; Calcium; Coculture Techniques; Cyclooxygenase Inhibitors; Dinoprostone; Erythrocytes; Humans; Hydroxyeicosatetraenoic Acids; Indomethacin; Ionophores; Leukotriene B4; Lipoxygenase; Lung Neoplasms; Neutrophils; Phospholipases A; Phospholipases A2; Subcellular Fractions; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; HL-60 Cells; Humans; Mitogen-Activated Protein Kinase Kinases; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Superoxides; Tetradecanoylphorbol Acetate; Tretinoin | 1996 |
Arachidonic acid metabolism in murine lymphoma cell sublines differing in radiation sensitivity.
Topics: Animals; Arachidonic Acid; Calcimycin; Cell Line; Hydrogen Peroxide; Hydroxyeicosatetraenoic Acids; Ionomycin; Lymphoma; Mice; Phospholipids; Prostaglandins; Radiation Tolerance; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; X-Rays | 1996 |
Inositol prevents folate-resistant neural tube defects in the mouse.
Topics: Animals; Arachidonic Acid; Embryo, Mammalian; Female; Folic Acid; Gene Expression Regulation, Developmental; In Vitro Techniques; Inositol; Male; Mice; Mice, Inbred CBA; Mice, Mutant Strains; Neural Tube Defects; Pregnancy; Protein Kinase C; Receptors, Retinoic Acid; Tetradecanoylphorbol Acetate; Up-Regulation | 1997 |
Induction of cyclooxygenase-1 in a human megakaryoblastic cell line (CMK) differentiated by phorbol ester.
Topics: Arachidonic Acid; Blotting, Northern; Blotting, Western; Cell Differentiation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoenzymes; Megakaryocytes; Membrane Proteins; Microscopy, Immunoelectron; Nitrobenzenes; Precipitin Tests; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1997 |
Glucocorticoids regulate both phorbol ester and calcium ionophore-induced endothelial prostacyclin synthesis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Annexins; Anti-Inflammatory Agents; Arachidonic Acid; Calcimycin; Calcium; Cattle; Cells, Cultured; Dexamethasone; Endothelium, Vascular; Epoprostenol; Fura-2; Glucocorticoids; Ionomycin; Ionophores; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1997 |
Phospholipase A2 has a role in proliferation but not in differentiation of HL-60 cells.
Topics: 3T3 Cells; Acetophenones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Blotting, Northern; Calcitriol; Cell Differentiation; Cell Division; Enzyme Inhibitors; Granulocytes; HL-60 Cells; Homosteroids; Humans; Mice; Phospholipases A; Phospholipases A2; Sesterterpenes; Terpenes; Tetradecanoylphorbol Acetate; Tretinoin | 1997 |
Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions.
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Basidiomycota; Carrageenan; Dermatitis; Female; Inflammation; Mice; Plant Extracts; Tetradecanoylphorbol Acetate; Triterpenes | 1997 |
Inhibition of cytosolic phospholipase A2 by annexin V in differentiated permeabilized HL-60 cells. Evidence of crucial importance of domain I type II Ca2+-binding site in the mechanism of inhibition.
Topics: Annexin A5; Arachidonic Acid; Bacterial Proteins; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Membrane Permeability; Cytosol; Enzyme Inhibitors; Female; Guanosine 5'-O-(3-Thiotriphosphate); HL-60 Cells; Humans; Indoles; Kinetics; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Placenta; Pregnancy; Protein Kinase C; Recombinant Proteins; Streptolysins; Tetradecanoylphorbol Acetate | 1997 |
Prostacyclin production after treatment of rat liver cells with tosyl-L-phenylalanine chloromethyl ketone and 12-O-tetradecanoylphorbol-13-acetate is mediated by a phorbol-ester-stimulated intermediate.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Epoprostenol; Isoenzymes; Kinetics; Liver; Membrane Proteins; Models, Biological; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Tosylphenylalanyl Chloromethyl Ketone | 1996 |
Ulinastatin, a human trypsin inhibitor, inhibits endotoxin-induced thromboxane B2 production in human monocytes.
Topics: Arachidonic Acid; Dose-Response Relationship, Immunologic; Drug Evaluation, Preclinical; Glycoproteins; Humans; Lipopolysaccharides; Lymphocyte Activation; Monocytes; Systemic Inflammatory Response Syndrome; Tetradecanoylphorbol Acetate; Thromboxane B2; Trypsin Inhibitors | 1997 |
Protein kinase C-independent activation of a novel nonspecific phospholipase C pathway by phorbol myristate acetate releases arachidonic acid for prostaglandin synthesis in MC3T3-E1 osteoblasts.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Line; Cyclohexanones; Diglycerides; Dinoprostone; Down-Regulation; Eicosanoids; Enzyme Activation; Lipoprotein Lipase; Membrane Lipids; Mice; Osteoblasts; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phospholipid Ethers; Phospholipids; Prostaglandins; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Type C Phospholipases | 1997 |
The Ca2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells.
Topics: Animals; Arachidonic Acid; Calcium; Calcium-Binding Proteins; Cattle; Cell Line; Enzyme Activation; Glycerophospholipids; Humans; Inositol Phosphates; Kidney; Parathyroid Glands; Phosphatidic Acids; Phospholipase D; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 1997 |
Antigen activation of mitogen-activated protein kinase in mast cells through protein kinase C-dependent and independent pathways.
Topics: Animals; Antigens; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Cycle Proteins; Cells, Cultured; Enzyme Activation; Enzyme Precursors; GTP-Binding Proteins; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Mast Cells; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Rats; Syk Kinase; Tetradecanoylphorbol Acetate; Thapsigargin | 1997 |
Tumor cell-endothelial cell interactions: evidence for roles for lipoxygenase products of arachidonic acid in metastasis.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Calcimycin; Cattle; Cell Adhesion; Endothelium, Vascular; Humans; Lipoxygenase; Lipoxygenase Inhibitors; Masoprocol; N-Formylmethionine Leucyl-Phenylalanine; Neoplasm Metastasis; Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Blockade of protein kinase C is involved in the inhibition by cycloheterophyllin of neutrophil superoxide anion generation.
Topics: Animals; Arachidonic Acid; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Inositol 1,4,5-Trisphosphate; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Dual effects of auranofin on prostaglandin E2 production by rat peritoneal macrophages.
Topics: Animals; Antirheumatic Agents; Arachidonic Acid; Auranofin; Calcimycin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; In Vitro Techniques; Ionophores; Isoenzymes; Macrophages, Peritoneal; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thapsigargin | 1997 |
Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.
Topics: Arachidonic Acid; Astrocytoma; Brain Neoplasms; Calcimycin; Calcium; Carbachol; Carcinogens; Cytosol; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ionophores; Phospholipases A; Phospholipases A2; Protein Kinase C; Receptors, Muscarinic; Tetradecanoylphorbol Acetate; Thapsigargin; Tumor Cells, Cultured | 1997 |
Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic beta-cell secretory responsiveness.
Topics: Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Male; Methylcholanthrene; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Functional dissociation between glucocorticoid-induced decrease in arachidonic acid release and inhibition of adrenocorticotropic hormone secretion in AtT-20 corticotrophs.
Topics: Adrenocorticotropic Hormone; Animals; Arachidonic Acid; Calcimycin; Cell Line; Corticotropin-Releasing Hormone; Dexamethasone; Dose-Response Relationship, Drug; Glucocorticoids; Isoproterenol; Melitten; Mice; Pituitary Gland; Potassium Chloride; Tetradecanoylphorbol Acetate | 1997 |
Cystic fibrosis gene mutation (deltaF508) is associated with an intrinsic abnormality in Ca2+-induced arachidonic acid release by epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Calcium; Cells, Cultured; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Ibuprofen; Lipoprotein Lipase; Mutation; Phospholipases A; Phospholipases A2; Precipitin Tests; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Multiple C-terminal serine phosphorylation accompanies both protein kinase C-dependent and -independent activation of cytosolic 85 kDa phospholipase A2 in macrophages.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Fusobacterium nucleatum; Gardnerella vaginalis; Macrophages, Peritoneal; Mice; Mice, Inbred Strains; Molecular Sequence Data; Phospholipases A; Phospholipases A2; Phosphopeptides; Phosphorylation; Protein Kinase C; Serine; Tetradecanoylphorbol Acetate | 1997 |
Electrogenic H+ pathway contributes to stimulus-induced changes of internal pH and membrane potential in intact neutrophils: role of cytoplasmic phospholipase A2.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cytoplasm; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Macrophages, Peritoneal; Membrane Potentials; Mice; Mice, Inbred Strains; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Patch-Clamp Techniques; Phospholipases A; Phospholipases A2; Phosphotyrosine; Proton Pumps; Sodium-Hydrogen Exchangers; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
Cross talk between substance P and melittin-activated cellular signaling pathways in rat lactotroph-enriched cell cultures.
Topics: Animals; Arachidonic Acid; Aristolochic Acids; Cells, Cultured; Enzyme Inhibitors; Female; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Melitten; Phenanthrenes; Phospholipases A; Phospholipases A2; Pituitary Gland, Anterior; Prolactin; Protein Kinase C; Quinacrine; Rats; Rats, Wistar; Signal Transduction; Substance P; Tetradecanoylphorbol Acetate; Tritium | 1997 |
Effect of topically applied cyclosporin A on arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation in mouse ear.
Topics: Acetylglucosaminidase; Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capillary Permeability; Cyclooxygenase Inhibitors; Cyclosporine; Dermatitis, Contact; Dexamethasone; Eicosanoids; Glucocorticoids; Immunosuppressive Agents; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Peroxidase; Pyrazoles; Tetradecanoylphorbol Acetate | 1997 |
Arachidonic acid stimulates protein kinase C-epsilon redistribution in heart cells.
Topics: Animals; Arachidonic Acid; Carcinogens; Cytoskeleton; Female; Fluorescent Antibody Technique; Isoenzymes; Microfilament Proteins; Muscle Contraction; Myocardium; Myofibrils; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1997 |
Effect of topically applied cyclooxygenase-2-selective inhibitors on arachidonic acid- and tetradecanoylphorbol acetate-induced dermal inflammation in the mouse.
Topics: Acetylglucosaminidase; Administration, Topical; Animals; Arachidonic Acid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Eruptions; Eicosanoids; Isoenzymes; Male; Mice; Mice, Inbred Strains; Peroxidase; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1997 |
Induction of apoptosis and potentiation of TNF- and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609.
Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Apoptosis; Arachidonic Acid; Bridged-Ring Compounds; Chromatin; Culture Media, Serum-Free; DNA Fragmentation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; fas Receptor; Humans; Kinetics; Leukemia, Myeloid; Norbornanes; Nucleosomes; Recombinant Proteins; Sphingomyelin Phosphodiesterase; Sphingosine; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
dl-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells.
Topics: Arachidonic Acid; Cell Adhesion; Cell Membrane; Cell Size; Cytosol; Dose-Response Relationship, Drug; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Protein Kinase C; Pseudopodia; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vitamin E | 1997 |
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism.
Topics: Adenosine Triphosphate; Arachidonic Acid; Calcium; Cell Line; Humans; Inositol Phosphates; Lysophospholipids; Pertussis Toxin; Phosphatidic Acids; Phosphorylcholine; Sphingosine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Cell Membrane; Cytochalasin B; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Lysophospholipids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein-Tyrosine Kinases; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1997 |
Differential activation of keratinocyte phospholipase A2S by tumor promoters and other irritants.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytosol; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Fatty Acids; Isoenzymes; Keratinocytes; Membrane Lipids; Mice; Naphthalenes; Oligonucleotides, Antisense; Papilloma; Phosphatidylcholines; Phospholipases A; Phospholipids; Pyrones; Recombinant Fusion Proteins; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1997 |
Vitamin E (alpha-tocopherol) enhances arachidonic acid release in rat heart myoblastic cells through the activation of cytosolic phospholipase A2.
Topics: Animals; Arachidonic Acid; Calcimycin; Cytosol; Enzyme Activation; Enzyme Inhibitors; Heart; Indoles; Ionophores; Isoenzymes; Muscle Proteins; Myocardium; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Vitamin E | 1997 |
Regulation of cytosolic phospholipase A2 in arachidonic acid release of rat-liver macrophages.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytosol; Diglycerides; Enzyme Activation; Ionophores; Isoenzymes; Lipopolysaccharides; Lipoprotein Lipase; Liver; Macrophages; Male; Membrane Lipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Zymosan | 1997 |
Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils.
Topics: Anilides; Arachidonic Acid; CD18 Antigens; Cell Adhesion Molecules; Flow Cytometry; Humans; Integrin alphaXbeta2; L-Selectin; Linoleic Acid; Linoleic Acids; Macrophage-1 Antigen; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate | 1997 |
Effects of PKC alpha activation on Ca2+ pump and K(Ca) channel in deoxygenated sickle cells.
Topics: Anemia, Sickle Cell; Arachidonic Acid; Calcimycin; Calcium; Calcium-Transporting ATPases; Chromatography, DEAE-Cellulose; Cytosol; Diglycerides; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Molecular Weight; Protein Kinase C; Protein Kinase C-alpha; Reference Values; Tetradecanoylphorbol Acetate | 1997 |
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cytosol; Dinoprostone; Down-Regulation; Drug Interactions; Flavonoids; Guinea Pigs; Indoles; Indomethacin; Maleimides; Muscle, Smooth; Phospholipases A; Phospholipases A2; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Trachea | 1997 |
Bradykinin-stimulated arachidonic acid release from MDCK cells is not protein kinase C dependent.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bradykinin; Calcimycin; Cell Line; Dogs; Drug Synergism; Enzyme Inhibitors; Indoles; Kidney; Kinetics; Maleimides; Phospholipases A; Phospholipases A2; Phosphorylation; Phosphoserine; Protein Kinase C; Tetradecanoylphorbol Acetate | 1997 |
Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Capsaicin; Collagenases; Curcumin; Dinoprostone; Hyaluronoglucosaminidase; Leukotriene B4; Leukotriene C4; Lysosomes; Macrophages, Peritoneal; Male; Membrane Lipids; Pancreatic Elastase; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Pulmonary and neutrophil responses to priming effects of platelet-activating factor in pigs.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Blood Gas Analysis; Blood Pressure; Carcinogens; Cyclooxygenase Inhibitors; Indomethacin; Lipopolysaccharides; Neutrophils; Platelet Activating Factor; Random Allocation; Respiratory Physiological Phenomena; Respiratory System; Superoxides; Swine; Tetradecanoylphorbol Acetate; Time Factors; Vascular Resistance | 1997 |
Differential routes of Ca2+ influx in Swiss 3T3 fibroblasts in response to receptor stimulation.
Topics: 3T3 Cells; Alprostadil; Angiotensin II; Animals; Arachidonic Acid; Bombesin; Bradykinin; Calcium; Calcium Channel Blockers; Diltiazem; Endothelins; Enzyme Activation; GTP-Binding Proteins; Inositol Phosphates; Mice; Nifedipine; Pertussis Toxin; Phospholipases A; Phospholipases A2; Platelet-Derived Growth Factor; Protein Kinase C; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Vasopressins; Virulence Factors, Bordetella | 1998 |
Bradykinin-stimulated cPLA2 phosphorylation is protein kinase C dependent in rabbit CCD cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Cells, Cultured; Cyclohexanones; Cytosol; Enzyme Inhibitors; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Phospholipases A; Phospholipases A2; Phosphorylation; Protease Inhibitors; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils.
Topics: Arachidonic Acid; Calcium; Catalase; Eicosanoids; Enzyme Inhibitors; Eosinophils; Female; Humans; Indoles; Leukotriene C4; Male; Maleimides; Naphthalenes; Phorbol 12,13-Dibutyrate; Platelet Activating Factor; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1998 |
Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells.
Topics: Animals; Arachidonic Acid; Cell Membrane; Cloning, Molecular; Cytosol; Diffusion; Diglycerides; Green Fluorescent Proteins; Isoenzymes; Luminescent Proteins; Nuclear Envelope; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, IgE; Recombinant Fusion Proteins; Second Messenger Systems; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
Modulation of K+ channels by arachidonic acid in T84 cells. I. Inhibition of the Ca(2+)-dependent K+ channel.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Carbachol; Cell Line; Cell Membrane; Colon; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Humans; Indomethacin; Inositol Phosphates; Intestinal Mucosa; Large-Conductance Calcium-Activated Potassium Channels; Masoprocol; Membrane Potentials; Patch-Clamp Techniques; Phospholipases A; Phospholipases A2; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Calcitriol transmembrane signalling: regulation of rat muscle phospholipase D activity.
Topics: Animals; Arachidonic Acid; Calcitriol; Calcium; Calcium Channel Blockers; Cell Membrane; Chelating Agents; Diglycerides; Egtazic Acid; Ethanol; Glycerophospholipids; GTP-Binding Proteins; Muscle, Skeletal; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Modulation of hepatocyte growth factor-induced scattering of HT29 colon carcinoma cells. Involvement of the MAPK pathway.
Topics: Actins; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Adhesion; Cell Movement; Collagen; Desmosomes; Enzyme Inhibitors; Extracellular Matrix Proteins; Flavonoids; Hepatocyte Growth Factor; HT29 Cells; Humans; Laminin; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amnionic WISH cells.
Topics: Amnion; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Organophosphonates; Phosphatidate Phosphatase; Phospholipase D; Phospholipases A; Phospholipases A2; Phosphorylation; Tetradecanoylphorbol Acetate | 1998 |
ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Astrocytes; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Ionophores; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Tetradecanoylphorbol Acetate | 1998 |
Protein tyrosine phosphorylation and calcium signaling in thyroid FRTL-5 cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; DNA; Genistein; Pertussis Toxin; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fos; Rats; Signal Transduction; Tetradecanoylphorbol Acetate; Thapsigargin; Thyroid Gland; Tyrosine; Vanadates; Virulence Factors, Bordetella | 1998 |
The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages.
Topics: Animals; Arachidonic Acid; Calcium; Cells, Cultured; Macrophage Activation; Macrophages, Peritoneal; Mice; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphorylation; Signal Transduction; Tetradecanoylphorbol Acetate; Zymosan | 1998 |
Evaluation of the cutaneous anti-inflammatory activity of azaspiranes.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line; Cyclooxygenase 1; Dermatitis, Contact; Dinoprostone; Ear; Edema; Humans; Immunosuppressive Agents; Isoenzymes; Leukotriene B4; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Monocytes; NF-kappa B; Peroxidase; Piperidines; Prostaglandin-Endoperoxide Synthases; Spiro Compounds; Tetradecanoylphorbol Acetate | 1998 |
Regulation of arachidonic acid release and metabolism by tumor promoters.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Bradykinin; Calcimycin; Carcinogens; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Inflammation; Isoenzymes; Kinetics; Membrane Proteins; Mice; Mice, Inbred Strains; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Proteins; Skin; Tetradecanoylphorbol Acetate | 1997 |
Eicosanoid production and growth regulation in rat intestinal epithelial cells.
Topics: Animals; Arachidonic Acid; Cell Division; Cell Line; DNA; DNA Replication; Eicosanoids; Intestinal Mucosa; Rats; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha | 1997 |
Induction of 12-lipoxygenase expression by epidermal growth factor is mediated by protein kinase C in A431 cells.
Topics: Arachidonate 12-Lipoxygenase; Arachidonic Acid; Carcinoma, Squamous Cell; Enzyme Induction; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Hydroquinones; Isoenzymes; Microsomes; Protein Kinase C; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cell Line; Cell Membrane; Cytosol; Enzyme Activation; Epidermal Cells; Hot Temperature; Isoenzymes; Keratinocytes; Kinetics; Linoleic Acid; Mice; Oleic Acid; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate | 1998 |
Arachidonic acid and human bone marrow stromal cells.
Topics: 6-Ketoprostaglandin F1 alpha; Arachidonic Acid; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Dinoprostone; Fatty Acids; Humans; Interleukin-6; Leukotriene B4; Lipid Metabolism; Phospholipids; Stromal Cells; Tetradecanoylphorbol Acetate; Tritium; Tumor Necrosis Factor-alpha | 1998 |
Differential effects of protein kinase C agonists on prostaglandin production and growth in human breast cancer cells.
Topics: Antineoplastic Agents; Arachidonic Acid; Breast Neoplasms; Bryostatins; Cell Division; Dinoprostone; Enzyme Activation; Female; Humans; Lactones; Macrolides; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.
Topics: Animals; Arachidonic Acid; Blood Platelets; Cell Membrane; CHO Cells; Cricetinae; Drug Evaluation, Preclinical; Edema; Enzyme Inhibitors; Furans; Hematocrit; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Mice; Platelet Membrane Glycoproteins; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Urea | 1998 |
Arachidonic acid (AA) and tetradecanoylphorbol acetate (TPA) exert systemic effects when applied topically in the mouse.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylglucosaminidase; Administration, Topical; Animals; Arachidonic Acid; Capillary Permeability; Ear; Indomethacin; Leukotriene B4; Male; Mice; Mice, Inbred Strains; Organ Size; Peroxidase; Tetradecanoylphorbol Acetate | 1998 |
Suppressed thromboxane production in endotoxin-desensitized THP-1 cells is not a result of decreased prostaglandin H synthase activity.
Topics: Arachidonic Acid; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Induction; Humans; Isoenzymes; Kinetics; Lipopolysaccharides; Membrane Proteins; Monocytes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Salmonella enteritidis; Tetradecanoylphorbol Acetate; Thromboxane A2; Transcription, Genetic | 1998 |
Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes.
Topics: Animals; Arachidonic Acid; Cell Line; Dinoprostone; Keratinocytes; Linoleic Acid; Mice; Tetradecanoylphorbol Acetate | 1998 |
Anti-inflammatory effect of YPE-01, a novel diarylheptanoid derivative, on dermal inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Chemotactic Factors; Chromatography, High Pressure Liquid; Diarylheptanoids; Ear; Edema; Hydroxyeicosatetraenoic Acids; Ionophores; Ketones; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Phenols; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Dependence of neutrophil activation on cell density and adhesion.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Calcium; Cell Adhesion; Cell Count; Cells, Cultured; Drug Synergism; Humans; Hydrogen-Ion Concentration; Hydroxyeicosatetraenoic Acids; Ionophores; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Coexpression of phospholipase A2 isoforms in rat striatal astrocytes.
Topics: Animals; Arachidonic Acid; Astrocytes; Calcimycin; Corpus Striatum; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Ionophores; Isoenzymes; Nerve Tissue Proteins; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Protein Kinase C; Quinacrine; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1998 |
3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Female; Inflammation; Japan; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Tetradecanoylphorbol Acetate; Triterpenes | 1998 |
Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol.
Topics: Animals; Arachidonic Acid; Carbachol; Cells, Cultured; Cinnamates; Group VI Phospholipases A2; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Lysophosphatidylcholines; Male; ortho-Aminobenzoates; Palmitic Acid; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Sincalide; Tetradecanoylphorbol Acetate; Verapamil | 1998 |
Lack of direct connection between arachidonic acid release and prostanoid synthesis upon differentiation of U937 cell.
Topics: Arachidonic Acid; Calcimycin; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Dinoprostone; Humans; Ionophores; Monocytes; Prostaglandins; Tetradecanoylphorbol Acetate; Thromboxane B2; Tretinoin | 1998 |
Phorbol ester-induced production of prostaglandin E2 from phosphatidylcholine through the activation of phospholipase D in UMR-106 cells.
Topics: Animals; Arachidonic Acid; Cell Line; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glycerophospholipids; Lipoprotein Lipase; Myristic Acid; Osteoblasts; Phosphatidate Phosphatase; Phosphatidic Acids; Phosphatidylcholines; Phospholipase D; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Signal Transduction; Tetradecanoylphorbol Acetate | 1998 |
Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Disease Models, Animal; Ear Diseases; Edema; Foot Diseases; Gossypium; Granuloma; Indomethacin; Inflammation; Lethal Dose 50; Male; Mice; Phycocyanin; Plant Proteins; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1998 |
Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils.
Topics: Arachidonic Acid; Basophils; Cells, Cultured; Complement C5a; Cytosol; Enzyme Activation; Enzyme Inhibitors; Humans; Interleukin-3; Ionomycin; Ionophores; Leukotriene C4; N-Formylmethionine Leucyl-Phenylalanine; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 1998 |
Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets.
Topics: Arachidonic Acid; Biological Transport, Active; Blood Platelets; Calcimycin; Calcium; Cytosol; Humans; In Vitro Techniques; Ionophores; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1998 |
GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (alphaT3-1).
Topics: Arachidonic Acid; Cell Line; Drug Tolerance; Enzyme Activation; Glycerophospholipids; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoenzymes; Kinetics; Phosphatidylinositols; Phospholipase D; Phospholipases A; Phospholipases A2; Pituitary Gland; Signal Transduction; Sodium Fluoride; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
Interference of myrtol standardized with inflammatory and allergic mediators.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Basophils; Cattle; Cyclohexanols; Dinoprostone; Drug Combinations; Drug Interactions; Eosinophils; Eucalyptol; Female; Guinea Pigs; Humans; Hyperemia; In Vitro Techniques; Inflammation; Leukemia, Basophilic, Acute; Leukotriene C4; Leukotriene D4; Leukotriene E4; Male; Mammary Glands, Animal; Menthol; Mice; Monoterpenes; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Rats; Terpenes; Tetradecanoylphorbol Acetate; Trachea; Tumor Cells, Cultured | 1998 |
Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion.
Topics: Acetaminophen; Antigens, CD; Arachidonic Acid; Aspirin; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Survival; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Macrophage-1 Antigen; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Sodium Salicylate; Tetradecanoylphorbol Acetate | 1998 |
Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies.
Topics: Animals; Antibodies; Apoptosis; Arachidonic Acid; Calcimycin; Cell Cycle; Enzyme Activation; fas Receptor; Glycerophospholipids; Humans; Mice; Necrosis; Phospholipase D; Phospholipases; Phospholipases A; Phospholipases A2; Phosphorylation; Ploidies; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Mature macrophage cell lines exhibit variable responses to LPS.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Immunoblotting; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophage Activation; Macrophage-1 Antigen; Macrophages; Mice; Phospholipases A; Phospholipases A2; Phospholipids; Signal Transduction; Tetradecanoylphorbol Acetate; Tritium | 1998 |
Distinct PKC isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Arachidonic Acid; Calcium; Cell Line; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Isoenzymes; Macrophages; Mice; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-epsilon; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 1998 |
Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Inhibitors; HL-60 Cells; Humans; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxazoles; Oxygen; Phosphoprotein Phosphatases; Phosphoproteins; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Role of Ca2+-ATPase inhibitors in activation of cytosolic phospholipase A2 in human polymorphonuclear neutrophils.
Topics: Arachidonic Acid; Arachidonic Acids; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Cell-Free System; Chelating Agents; Cytosol; DNA, Complementary; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Lipid Metabolism; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Binding; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; U937 Cells | 1999 |
Study on the activation of phospholipases A2 by purinergic agonists in rat submandibular ductal cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cations, Divalent; Cell Membrane Permeability; Enzyme Activation; In Vitro Techniques; Male; Oleic Acid; Phospholipases A; Phospholipases A2; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Staurosporine; Submandibular Gland; Tetradecanoylphorbol Acetate | 1999 |
Regulation of lung surfactant secretion by phospholipase A2.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Cinnamates; Cyclohexanones; Diglycerides; Enzyme Inhibitors; Lipoprotein Lipase; Male; ortho-Aminobenzoates; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Sprague-Dawley; Terbutaline; Tetradecanoylphorbol Acetate | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
Enhancement of free fatty acid incorporation into phospholipids by choline plus cytidine.
Topics: Animals; Arachidonic Acid; Carbon Radioisotopes; Carcinogens; Choline; Choline-Phosphate Cytidylyltransferase; Cytidine; Cytidine Triphosphate; Enzyme Inhibitors; Ethanolamine; Fatty Acids, Nonesterified; Glycerol; Neurons; PC12 Cells; Phospholipids; Phosphorylation; Rats; Tetradecanoylphorbol Acetate; Tritium | 1999 |
Potentiating effects of hyper-osmolality and epidermal growth factor on the release of arachidonic acid in human glomerular mesangial cells.
Topics: Arachidonic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Epidermal Growth Factor; Glomerular Mesangium; Glucose; Humans; Mannitol; Osmolar Concentration; Solutions; Tetradecanoylphorbol Acetate | 1999 |
Both dopamine and the putative dopamine D3 receptor antagonist PNU-99194A induce a biphasic inhibition of phorbol ester-stimulated arachidonic acid release from CHO cells transfected with the dopamine D3 receptor.
Topics: Animals; Arachidonic Acid; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Indans; Pertussis Toxin; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetradecanoylphorbol Acetate; Transfection; Virulence Factors, Bordetella | 1999 |
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Chronic Disease; Dermatitis; Diglycerides; Edema; Female; Flavonoids; Inula; Magnetic Resonance Spectroscopy; Mediterranean Region; Mice; Plants, Medicinal; Sesquiterpenes; Tetradecanoylphorbol Acetate | 1999 |
Roles of G-protein beta gamma, arachidonic acid, and phosphorylation inconvergent activation of an S-like potassium conductance by dopamine, Ala-Pro-Gly-Trp-NH2, and Phe-Met-Arg-Phe-NH2.
Topics: Amino Acid Sequence; Animals; Arachidonic Acid; Cyclic AMP; Dopamine; Electric Conductivity; Enzyme Inhibitors; FMRFamide; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Lymnaea; Molecular Sequence Data; Neuropeptides; Phosphorylation; Potassium Channels; Signal Transduction; Tetradecanoylphorbol Acetate | 1999 |
Effect of steroidal saponins of Anemarrhenae rhizoma on superoxide generation in human neutrophils.
Topics: Arachidonic Acid; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Prednisolone; Saponins; Superoxides; Tetradecanoylphorbol Acetate | 1999 |
Inhibition by tectorigenin and tectoridin of prostaglandin E2 production and cyclooxygenase-2 induction in rat peritoneal macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drugs, Chinese Herbal; Enzyme Induction; Isoenzymes; Isoflavones; Macrophages, Peritoneal; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thapsigargin | 1999 |
Involvement of group VI Ca2+-independent phospholipase A2 in protein kinase C-dependent arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Diglycerides; Egtazic Acid; Group VI Phospholipases A2; Indoles; Leukemia P388; Maleimides; Mice; Naphthalenes; Oligonucleotides, Antisense; Organophosphonates; Phospholipases A; Phospholipases A2; Protein Kinase C; Pyrones; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zymosan | 1999 |
Protein kinase C epsilon-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cell Line; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Extracellular Space; Flavonoids; Indoles; Isoenzymes; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Thionucleotides; Tritium; Uridine Triphosphate | 1999 |
Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Dexamethasone; Ear Diseases; Edema; Eicosanoids; Inflammation; Isoenzymes; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Skin; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Priming effect of calcium ionophores on phorbol ester-induced respiratory burst in mouse peritoneal neutrophils.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Ionomycin; Mice; Neutrophils; Phospholipases A; Phospholipases A2; Reactive Oxygen Species; Respiratory Burst; Tetradecanoylphorbol Acetate | 1999 |
Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin.
Topics: Acute Disease; Animals; Arachidonic Acid; Biological Transport; Carcinogens; Chemotaxis, Leukocyte; Cyclooxygenase 2; Dermatitis; Dermatologic Agents; Edema; Isoenzymes; Leukocytes; Mice; Prostaglandin-Endoperoxide Synthases; Skin; Tetradecanoylphorbol Acetate | 1999 |
Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells.
Topics: Amnion; Arachidonic Acid; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Membrane Proteins; Naphthalenes; Nitrobenzenes; Pancreatitis-Associated Proteins; Phosphatidate Phosphatase; Phosphodiesterase Inhibitors; Propranolol; Prostaglandin-Endoperoxide Synthases; Pyrones; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1999 |
Cytosolic phospholipase A2-mediated regulation of phospholipase D2 in leukocyte cell lines.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; COS Cells; Cytosol; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Leukemia L1210; Leukemia P388; Leukocytes; Lysophosphatidylcholines; Mice; Oligonucleotides, Antisense; Phospholipase D; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; U937 Cells | 1999 |
A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+.
Topics: 17-alpha-Hydroxyprogesterone; Animals; Arachidonic Acid; Calcium; Calcium Signaling; Cells, Cultured; Drug Synergism; Fura-2; Gonadotropin-Releasing Hormone; Ionomycin; Leydig Cells; Luteinizing Hormone; Male; Melatonin; Pertussis Toxin; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Testosterone; Tetradecanoylphorbol Acetate; Thapsigargin; Virulence Factors, Bordetella | 1999 |
Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Arachidonic Acid; Cell Transformation, Neoplastic; Enzyme Induction; Fibroblasts; Mice; Mice, Inbred C3H; Polychlorinated Dibenzodioxins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Tetradecanoylphorbol Acetate | 2000 |
Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.
Topics: Animals; Arachidonic Acid; Calcium; Cell Aggregation; Dose-Response Relationship, Drug; Eosinophils; Female; Guinea Pigs; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Phospholipases A; Pyrans; Quinacrine; Quinolones; Tetradecanoylphorbol Acetate; Tetrazoles | 1999 |
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; COS Cells; Cyclopentanes; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; I-kappa B Kinase; Jurkat Cells; Molecular Sequence Data; NF-kappa B; Prostaglandin D2; Prostaglandins A; Protein Serine-Threonine Kinases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2000 |
Fatty acid cyclooxygenase induction and prostaglandin D synthesis in a human megakaryoblastic cell line CMK differentiated by phorbol ester.
Topics: Arachidonic Acid; Cell Differentiation; Cell Line; Cyclooxygenase 1; Enzyme Induction; Glutathione; Humans; Intramolecular Oxidoreductases; Isoenzymes; Lipocalins; Megakaryocytes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins D; Tetradecanoylphorbol Acetate | 1999 |
Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Cell Polarity; Cyclic AMP-Dependent Protein Kinases; Cyclohexanones; Cyclooxygenase Inhibitors; Dogs; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Heterotrimeric GTP-Binding Proteins; Intercellular Signaling Peptides and Proteins; Ionomycin; Lipoprotein Lipase; Lipoxygenase Inhibitors; Organophosphonates; Peptides; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Protein Kinase C; Ricin; Signal Transduction; Tetradecanoylphorbol Acetate; Wasp Venoms | 2000 |
Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Adhesion Molecules; Cell Differentiation; Complement C3; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neural Cell Adhesion Molecules; Neurites; Neurons; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; ras Proteins; Rats; Receptors, Fibroblast Growth Factor; Tetradecanoylphorbol Acetate | 2000 |
Subtype-specific translocation of diacylglycerol kinase alpha and gamma and its correlation with protein kinase C.
Topics: Animals; Arachidonic Acid; Cell Membrane; CHO Cells; COS Cells; Cricetinae; Cytoplasm; Diacylglycerol Kinase; Golgi Apparatus; Green Fluorescent Proteins; Isoenzymes; Kinetics; Luminescent Proteins; Mutagenesis, Site-Directed; Protein Kinase C; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Chloroquine: a multipotent inhibitor of human platelets in vitro.
Topics: Adult; Arachidonic Acid; Blood Platelets; Calcimycin; Chloroquine; Dose-Response Relationship, Drug; Epinephrine; Humans; Malondialdehyde; Middle Aged; Platelet Aggregation; Serotonin; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2; Time Factors; Tritium | 2000 |
Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation.
Topics: Animals; Anisomycin; Arachidonic Acid; Calcimycin; Calcium; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ionophores; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NADPH Oxidases; Okadaic Acid; Phospholipase D; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Synthesis Inhibitors; Serine; Tetradecanoylphorbol Acetate; Time Factors; Zymosan | 2000 |
Involvement of different protein kinases and phospholipases A2 in phorbol ester (TPA)-induced arachidonic acid liberation in bovine platelets.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcimycin; Cattle; Cells, Cultured; Group IV Phospholipases A2; Phospholipases A; Phospholipases A2; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 2000 |
Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; Cells, Cultured; Cytosol; Diglycerides; Drug Synergism; Enzyme Activation; Fatty Acids, Unsaturated; Heart; Isoenzymes; Male; Myocardial Contraction; Myocardium; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Tetradecanoylphorbol Acetate | 2000 |
Activation of ERK1/2 and cPLA(2) by the p55 TNF receptor occurs independently of FAN.
Topics: Animals; Antigens, CD; Arachidonic Acid; B-Lymphocytes; Cells, Cultured; Cytoplasm; Drug Synergism; Fibroblasts; Intracellular Signaling Peptides and Proteins; Ionophores; MAP Kinase Kinase Kinase 1; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Sequence Deletion; Signal Transduction; Sphingomyelin Phosphodiesterase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2000 |
cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium.
Topics: Animals; Arachidonic Acid; Dose-Response Relationship, Drug; Guinea Pigs; Immunoblotting; In Vitro Techniques; Linoleic Acid; Myocardial Contraction; Myocardium; Myosins; Palmitic Acid; Palmitic Acids; Papillary Muscles; Perfusion; Protein Kinase C; Tetradecanoylphorbol Acetate | 2000 |
H(2)O(2) opens BK(Ca) channels via the PLA(2)-arachidonic acid signaling cascade in coronary artery smooth muscle.
Topics: Animals; Arachidonic Acid; Coronary Vessels; Enzyme Inhibitors; Hydrogen Peroxide; In Vitro Techniques; Indoles; Ion Channel Gating; Isometric Contraction; Large-Conductance Calcium-Activated Potassium Channels; Lipoxygenase Inhibitors; Muscle, Smooth, Vascular; Naphthalenes; Patch-Clamp Techniques; Phospholipases A; Potassium Channels; Potassium Channels, Calcium-Activated; Protein Kinase C; Signal Transduction; Swine; Tetradecanoylphorbol Acetate | 2000 |
Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?
Topics: Animals; Antibodies; Arachidonic Acid; Cell Division; Clinical Trials, Phase II as Topic; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Dinoprostone; DNA-Binding Proteins; Granulocyte-Macrophage Colony-Stimulating Factor; HL-60 Cells; Humans; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Isoenzymes; Ketorolac; Mice; Mice, Inbred BALB C; Models, Biological; Oropharyngeal Neoplasms; Paracrine Communication; Prostaglandin-Endoperoxide Synthases; Receptors, Interleukin-6; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured | 2000 |
The induction of cyclooxygenase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-kappaB.
Topics: Arachidonic Acid; Biotransformation; Carcinogens; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; DNA-Binding Proteins; Enzyme Induction; Humans; I-kappa B Proteins; Isoenzymes; Macrophages; Membrane Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Nicotiana; Nitrosamines; Plants, Toxic; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; U937 Cells | 2000 |
Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase.
Topics: Arachidonic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Dinoprost; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Interleukin-1; Intramolecular Oxidoreductases; Lipopolysaccharides; Muscle, Smooth, Vascular; Prostaglandin D2; Prostaglandin H2; Prostaglandin-E Synthases; Prostaglandins H; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saphenous Vein; Tetradecanoylphorbol Acetate; Tin Compounds; Tumor Necrosis Factor-alpha; Umbilical Veins | 2000 |
Basal cPLA(2) phosphorylation is sufficient for Ca(2+)-induced full activation of cPLA(2) in A549 epithelial cells.
Topics: Acetophenones; Arachidonic Acid; Benzopyrans; Calcium; Cell Line; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Mitogenic signal of epidermal growth factor in chick embryo hepatocytes: role of PKCalpha.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Chick Embryo; Diglycerides; Dinoprostone; DNA; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Hepatocytes; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mitogens; Myristic Acid; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Quinacrine; Signal Transduction; Tetradecanoylphorbol Acetate; Thymidine | 2000 |
Cytosolic phospholipase A2-alpha associates with plasma membrane, endoplasmic reticulum and nuclear membrane in glomerular epithelial cells.
Topics: Animals; Arachidonic Acid; Calcium; Cell Membrane; Cell Nucleus; Cells, Cultured; Centrifugation, Density Gradient; Complement Membrane Attack Complex; Cytosol; Endoplasmic Reticulum; Epithelial Cells; Fluorescent Antibody Technique; Golgi Apparatus; Group IV Phospholipases A2; Hydrolysis; Intracellular Membranes; Ionomycin; Kidney Glomerulus; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Tetradecanoylphorbol Acetate; Triiodobenzoic Acids | 2001 |
A combination of lactacystin and 12-O-tetradecanoylphorbol-13-acetate enhances the release of arachidonic acid from cells in cultures: release is reduced in confluent and serum deprived cells.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Cell Division; Cells, Cultured; Contact Inhibition; Culture Media; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Gliotoxin; Group IV Phospholipases A2; Hepatocytes; Immunosuppressive Agents; Multienzyme Complexes; Muscle, Smooth, Vascular; Neuroglia; Organophosphonates; Phospholipases A; Phospholipases A2; Proteasome Endopeptidase Complex; Pulmonary Artery; Rats; Sodium Salicylate; Tetradecanoylphorbol Acetate | 2000 |
Lactacystin stimulates arachidonic acid metabolism in rat liver cells: effects of cell density on arachidonic acid release, PGI2 production and cyclooxygenase activity.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Cell Count; Cells, Cultured; Contact Inhibition; Culture Media, Serum-Free; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Epoprostenol; Hepatocytes; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 2000 |
Effects of phycocyanin extract on prostaglandin E2 levels in mouse ear inflammation test.
Topics: Animals; Arachidonic Acid; Dinoprostone; Ear, External; Edema; Indicators and Reagents; Inflammation; Male; Mice; Phospholipases A; Phospholipases A2; Phycocyanin; Tetradecanoylphorbol Acetate | 2000 |
In vitro based index of topical anti-inflammatory activity to compare a series of NSAIDs.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibroblasts; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Skin; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes.
Topics: Animals; Arachidonic Acid; CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Cyclooxygenase 2; Cytosol; Dinoprostone; Enzyme Inhibitors; Inflammation; Isoenzymes; Keratinocytes; Keratins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases; Phospholipases A; Phospholipids; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Skin; Tetradecanoylphorbol Acetate | 2001 |
Contrasting effect of interleukin-4 on the expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in peritoneal macrophages from control and ovalbumin-sensitized rats.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Carrier Proteins; Cholesterol Esters; Cytosol; Gene Expression Regulation; Interleukin-4; Macrophages, Peritoneal; Male; Membrane Proteins; Ovalbumin; Phospholipases A; Phospholipases A2; Phospholipids; Rats; Tetradecanoylphorbol Acetate | 2001 |
Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade.
Topics: Animals; Arachidonic Acid; Cation Transport Proteins; Cells, Cultured; Cholecystokinin; Colforsin; DNA-Binding Proteins; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Flavonoids; Humans; Indoles; Isoquinolines; Kinetics; Maleimides; Membrane Potentials; Membrane Transport Proteins; Patch-Clamp Techniques; Pituitary Gland, Anterior; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase Inhibitors; Protein Kinases; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone; Trans-Activators; Transcriptional Regulator ERG; Tyrphostins; Vasoactive Intestinal Peptide | 2001 |
Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes.
Topics: Active Transport, Cell Nucleus; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Calcium; Calcium Signaling; Cell Line; Cell Nucleus; Enzyme Inhibitors; Humans; Ionophores; Leukotrienes; Membrane Lipids; Monocytes; Naphthalenes; Neutrophils; Phospholipases A; Phospholipids; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 2001 |
Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D.
Topics: 1-Butanol; Aminobenzoates; Animals; Arachidonic Acid; Calcium Signaling; Cell Line; Chlorobenzoates; Cinnamates; Enzyme Activation; Enzyme Inhibitors; Lysophospholipids; Muscle, Smooth, Vascular; ortho-Aminobenzoates; Phospholipase D; Phospholipases A; Phospholipases A2; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Vasopressins | 2001 |
Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells.
Topics: Animals; Aorta; Arachidonic Acid; Cattle; Cells, Cultured; Coenzyme A Ligases; Diglycerides; Enzyme Inhibitors; Fatty Acids, Nonesterified; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oleic Acid; Palmitic Acid; Protein Kinase C; Stearic Acids; Tetradecanoylphorbol Acetate; Triazenes | 2001 |
Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Dexamethasone; Dinoprostone; Drugs, Chinese Herbal; Enzyme Induction; Indomethacin; Isoenzymes; Macrophages, Peritoneal; Membrane Proteins; Oleanolic Acid; Plant Roots; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Saponins; Tetradecanoylphorbol Acetate; Triterpenes | 2001 |
Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Carrier Proteins; Cells, Cultured; Cytosol; Injections, Subcutaneous; Interleukin-4; Macrophages, Peritoneal; Male; Membrane Proteins; Ovalbumin; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred BN; Tetradecanoylphorbol Acetate | 2001 |
Olive oil decreases both oxidative stress and the production of arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages.
Topics: Animals; Arachidonic Acid; Corn Oil; Dinoprostone; Fish Oils; Macrophages, Peritoneal; Male; Nitric Oxide; Olive Oil; Oxidative Stress; Plant Oils; Prostaglandin-Endoperoxide Synthases; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxides; Tetradecanoylphorbol Acetate | 2001 |
Anti-inflammatory and anti-allergic actions by oral administration of a perilla leaf extract in mice.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Arachidonic Acid; Dermatitis, Contact; Disease Models, Animal; Edema; Magnoliopsida; Male; Mice; Mice, Inbred ICR; Oxazolone; Plant Extracts; Tetradecanoylphorbol Acetate | 2001 |
Effect of three flavonoids, 5,7,3',4'-tetrahydroxy-3-methoxy flavone, luteolin, and quercetin, on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophil.
Topics: Arachidonic Acid; Blood Proteins; Flavonoids; Humans; In Vitro Techniques; Luteolin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Quercetin; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2001 |
Role of phospholipases A(2) in growth-dependent changes in prostaglandin release from 3T6 fibroblasts.
Topics: Animals; Arachidonic Acid; Cell Culture Techniques; Cell Division; Cell Line; Culture Media; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Group V Phospholipases A2; Group VI Phospholipases A2; Intracellular Membranes; Isoenzymes; Mice; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 2001 |
Effects of liposomes of different phospholipid composition on the induction of respiratory burst in human blood monocytes and alveolar macrophages.
Topics: Arachidonic Acid; Calcimycin; Diglycerides; Fatty Acids; Humans; Ionophores; Liposomes; Macrophage Activation; Macrophages, Alveolar; Monocytes; NADPH Oxidases; Phosphatidylcholines; Phospholipids; Respiratory Burst; Tetradecanoylphorbol Acetate | 2001 |
Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils.
Topics: Arachidonic Acid; Cell Separation; Humans; In Vitro Techniques; Indicators and Reagents; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Tyrosine Phosphatases; Spirostans; Stereoisomerism; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate | 2001 |
New insights into the mechanism of action of the anti-inflammatory triterpene lupeol.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cytokines; Dinoprostone; Dose-Response Relationship, Drug; Edema; Inflammation; Interleukin-1; Leukotriene C4; Macrophages, Peritoneal; Male; Mice; Models, Animal; Nitrites; Pentacyclic Triterpenes; Phytotherapy; Pimenta; Plant Extracts; Tetradecanoylphorbol Acetate; Triterpenes; Tumor Necrosis Factor-alpha | 2001 |
Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis.
Topics: Animals; Apoptosis; Arachidonic Acid; Blotting, Western; Cell Line; Enzyme Activation; Flow Cytometry; Hydrogen Peroxide; Lysosomes; Mice; Microscopy, Fluorescence; Oxidative Stress; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate | 2001 |
Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Meiosis; Oocytes; Ovarian Follicle; Protein Kinase C; Receptors, LHRH; Testosterone; Tetradecanoylphorbol Acetate | 2002 |
Importance of C1B domain for lipid messenger-induced targeting of protein kinase C.
Topics: Animals; Arachidonic Acid; Ceramides; CHO Cells; COS Cells; Cricetinae; Cytoplasm; Golgi Apparatus; Green Fluorescent Proteins; HeLa Cells; Humans; Isoenzymes; Luminescent Proteins; Point Mutation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 2002 |
CX-659S: a novel diaminouracil derivative that has antioxidative and acute anti-inflammatory activities.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Ascorbic Acid; Chromans; Dose-Response Relationship, Drug; Ear; Edema; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Uracil | 2002 |
Increased free radical production in hypertension due to increased expression of the NADPH oxidase subunit p22(phox) in lymphoblast cell lines.
Topics: Arachidonic Acid; Cell Line; Female; Free Radicals; Humans; Hypertension; Luminescent Measurements; Lymphocytes; Male; Membrane Transport Proteins; Middle Aged; NADPH Dehydrogenase; NADPH Oxidases; Phosphoproteins; Tetradecanoylphorbol Acetate | 2002 |
Implication of three isoforms of PLA(2) in human T-cell proliferation.
Topics: Arachidonic Acid; Arachidonic Acids; Calcium; Cell Division; Enzyme Inhibitors; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Interleukin-2; Ionomycin; Isoenzymes; Jurkat Cells; Phospholipases A; RNA, Messenger; Tetradecanoylphorbol Acetate; Tritium | 2002 |
Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arachidonic Acid; Arginine Vasopressin; Cell Line; Enzyme Activation; Group VI Phospholipases A2; Kinetics; MAP Kinase Signaling System; Molecular Sequence Data; Muscle, Smooth; Naphthalenes; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Protein Transport; Pyrones; Rats; Stereoisomerism; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 2002 |
Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin.
Topics: Arachidonic Acid; Benzoquinones; Calcimycin; Cells, Cultured; Enzyme Inhibitors; Heat-Shock Response; Hot Temperature; Humans; Ionophores; Lactams, Macrocyclic; Leukocytes, Mononuclear; Quinones; Tetradecanoylphorbol Acetate | 2002 |
PGE2 reduces arachidonic acid release in murine podocytes: evidence for an autocrine feedback loop.
Topics: Animals; Antigens, Human Platelet; Arachidonic Acid; Autocrine Communication; Cell Line, Transformed; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epithelial Cells; Feedback; Isoenzymes; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Tetradecanoylphorbol Acetate | 2003 |
Inhibition of prostaglandin E(2) production by taiwanin C isolated from the root of Acanthopanax chiisanensis and the mechanism of action.
Topics: Animals; Arachidonic Acid; Araliaceae; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Lactones; Lignans; Macrophages, Peritoneal; Male; Membrane Proteins; Plant Roots; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin; Tritium | 2002 |
Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Astrocytes; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Growth Substances; Isoenzymes; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2002 |
Effect of S-(1,2-dicarboxyethyl) glutathione and S-(1,2-dicarboxyethyl) cysteine on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.
Topics: Arachidonic Acid; Blood Proteins; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Glutathione; Humans; Immunoblotting; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 2002 |
A new dual inhibitor of arachidonate metabolism isolated from Helichrysum italicum.
Topics: Acetophenones; Analgesics; Animals; Arachidonic Acid; Carrageenan; Dose-Response Relationship, Drug; Ear; Edema; Female; Free Radicals; Glucosides; Helichrysum; Hindlimb; Inflammation; Leukotriene B4; Lipid Peroxidation; Mice; Neutrophils; Peroxidase; Phospholipases A; Plant Extracts; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 2003 |
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Benzphetamine; Cloning, Molecular; Conserved Sequence; Cytochrome P-450 Enzyme System; Fasting; Fundulidae; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Male; Molecular Sequence Data; Multigene Family; Organ Specificity; Phylogeny; Rats; Rats, Inbred F344; RNA, Messenger; Sequence Alignment; Tetradecanoylphorbol Acetate; Vertebrates | 2003 |
Pharmaco-toxicological study of diterpenoids.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apiaceae; Arachidonic Acid; Chile; Diterpenes; Dose-Response Relationship, Drug; Edema; Female; Indicators and Reagents; Indomethacin; Lipoxygenase Inhibitors; Male; Mice; Molecular Conformation; Naproxen; Pain Measurement; Plants, Medicinal; Structure-Activity Relationship; Sulfonamides; Tetradecanoylphorbol Acetate | 2003 |
Inhibition of protein kinase C by synthetic xanthone derivatives.
Topics: Alkaloids; Arachidonic Acid; Benzophenanthridines; Enzyme Inhibitors; Immunoblotting; Immunochemistry; Indicators and Reagents; Isoenzymes; Phenanthridines; Phenotype; Phosphatidylserines; Piperidines; Plasmids; Protein Kinase C; Saccharomyces cerevisiae; Tetradecanoylphorbol Acetate; Xanthines | 2003 |
Biphasic regulation of renal proximal bicarbonate absorption by luminal AT(1A) receptor.
Topics: Angiotensin II; Animals; Arachidonic Acid; Bicarbonates; Biological Transport; Calcium; Carcinogens; Kidney Tubules, Proximal; Male; Mice; Mice, Knockout; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 2003 |
Does the release of arachidonic acid from cells play a role in cancer chemoprevention?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Arachidonic Acid; Catechin; Celecoxib; Cholecalciferol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epoprostenol; Humans; Indomethacin; Isoenzymes; Kidney; Liver; Membrane Proteins; Neoplasms; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Retinoids; Sulfonamides; Tetradecanoylphorbol Acetate | 2003 |
Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFalpha, LPS and M-CSF in human monocytes and macrophages.
Topics: Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Cytosol; Dinoprostone; Humans; Isoenzymes; Lipopolysaccharides; Macrophage Colony-Stimulating Factor; Macrophages; Membrane Proteins; Monocytes; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Effect of three triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation and tyrosyl phosphorylation and translocation of p47(phox) and p67(phox) to cell membrane in human neutrophil.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Humans; Immunoblotting; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; Plant Roots; Protein Transport; Saponins; Superoxides; Tetradecanoylphorbol Acetate; Triterpenes; Tyrosine | 2003 |
Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression.
Topics: Animals; Arachidonic Acid; Dermatitis; Drugs, Chinese Herbal; Flavanones; Flavonoids; Gene Expression; Inflammation; Male; Mice; Mice, Inbred ICR; Plant Extracts; Scutellaria baicalensis; Tetradecanoylphorbol Acetate | 2003 |
Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages RAW 264.7.
Topics: Animals; Arachidonic Acid; Cell Line; Cyclooxygenase 2; Dinoprostone; Hydrogen Peroxide; Isoenzymes; Leukotriene B4; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Olive Oil; Oxidative Stress; Phenylethyl Alcohol; Plant Oils; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Sitosterols; Squalene; Superoxides; Tetradecanoylphorbol Acetate | 2003 |
Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils.
Topics: Animals; Arachidonic Acid; Calcimycin; Dietary Fats, Unsaturated; Dinoprostone; Eicosanoids; Fatty Acids; Fatty Acids, Essential; Fish Oils; gamma-Linolenic Acid; Glucuronidase; Glycogen; Hydrogen Peroxide; Inflammation; Linoleic Acid; Linoleic Acids; Lysosomes; Male; Muramidase; Neutrophils; Oenothera biennis; Oleic Acid; Olive Oil; Peritoneum; Peroxidase; Plant Oils; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxides; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2004 |
Enzymatic synthesis of tea theaflavin derivatives and their anti-inflammatory and cytotoxic activities.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Biflavonoids; Biochemistry; Carcinoma, Squamous Cell; Catechin; Cell Division; Cells, Cultured; Colonic Neoplasms; Drug Evaluation, Preclinical; Ear Diseases; Edema; Esophageal Neoplasms; Female; Horseradish Peroxidase; Humans; Macrophages; Mice; Mice, Inbred Strains; Structure-Activity Relationship; Tea; Tetradecanoylphorbol Acetate; Toxicity Tests; Tumor Cells, Cultured | 2004 |
Differential effect of phosphodiesterase IV inhibitor RP73401 on various inflammatory and immune responses relevent to rheumatoid arthritis.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Arachidonic Acid; Arthritis, Experimental; Arthritis, Rheumatoid; Benzamides; Cell Physiological Phenomena; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Drug Evaluation, Preclinical; Ear Diseases; Edema; Humans; Immunity, Active; Inflammation; Lipopolysaccharides; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Nitric Oxide; Pyridines; Rats; Rats, Sprague-Dawley; Spleen; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells | 2004 |
AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.
Topics: Animals; Arachidonic Acid; Blotting, Western; Bradykinin; Calcium; COS Cells; Enzyme Activation; Gene Library; Glutathione Transferase; Humans; Inositol Phosphates; Isoenzymes; Membrane Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Neoplasm Proteins; NIH 3T3 Cells; Phospholipase C beta; Phospholipase C gamma; Phosphorylation; Plasmids; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Serine; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Type C Phospholipases; Tyrosine | 2004 |
In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Calcimycin; Cuba; Dexamethasone; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ear, External; Edema; Eicosanoids; Indomethacin; Interferon-gamma; Leukotriene B4; Lipopolysaccharides; Macrophages; Male; Mangifera; Mice; Oleanolic Acid; Peroxidase; Phospholipases A; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Plants, Medicinal; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Water; Xanthones | 2004 |
Melittin shares certain cellular effects with phorbol ester tumour promoters.
Topics: Animals; Arachidonic Acid; Bee Venoms; Bees; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Melanoma; Melitten; Mice; Prostaglandins; Tetradecanoylphorbol Acetate | 1979 |
Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.
Topics: Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; Glutathione; Humans; Indoles; Iron; Lipid Peroxidation; Maleimides; Oxidative Stress; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Expression of cytosolic phospholipase A2 alpha in murine C12 cells, a variant of L929 cells, induces arachidonic acid release in response to phorbol myristate acetate and Ca2+ ionophores, but not to tumor necrosis factor-alpha.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cell Line; Cytosol; Gene Expression Regulation, Enzymologic; Group IV Phospholipases A2; Humans; Ionophores; Isoenzymes; Mice; Phospholipases A; Phospholipases A2; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2004 |
The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
Topics: Animals; Arachidonic Acid; Calgranulin A; Calgranulin B; Cattle; Cell Line, Tumor; Cell-Free System; Enzyme Activation; Gene Expression; Gene Silencing; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, Knockout; NADPH Oxidases; Neutrophils; Oligonucleotides, Antisense; Phosphoproteins; Polymerase Chain Reaction; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Reactive Oxygen Species; Recombinant Fusion Proteins; Respiratory Burst; RNA, Messenger; Superoxides; Tetradecanoylphorbol Acetate | 2005 |
Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells.
Topics: Arachidonic Acid; Cell Membrane; Cells, Cultured; Coronary Vessels; Endothelial Cells; Enzyme Activation; Group VI Phospholipases A2; Humans; Immunoblotting; Phospholipases A; Phospholipases A2; Phospholipids; Platelet Activating Factor; Polymerase Chain Reaction; Protein Isoforms; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 2005 |
A downstream role for protein kinase Calpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells.
Topics: Arachidonic Acid; Blotting, Western; Cell Death; Cell Survival; Cytosol; Down-Regulation; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Immunohistochemistry; Leukocytes, Mononuclear; Oligonucleotides, Antisense; Peroxynitrous Acid; Phospholipases A; Phospholipases A2; Protein Kinase C; Protein Kinase C-alpha; Rhodamine 123; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tritium; Tumor Cells, Cultured; U937 Cells | 2005 |
Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Arachidonic Acid; Caspase 3; Caspases; Cell Survival; Cyclooxygenase 2; Enzyme Activation; Guanine Nucleotide Dissociation Inhibitors; HL-60 Cells; Humans; Jurkat Cells; Membrane Proteins; Poly(ADP-ribose) Polymerases; PPAR gamma; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors; Tetradecanoylphorbol Acetate | 2005 |
Activity of taraxasteryl acetate on inflammation and heat shock protein synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Asteraceae; Croton Oil; Dose-Response Relationship, Drug; Edema; Female; Flow Cytometry; Granuloma, Foreign-Body; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; Male; Mice; Mice, Inbred Strains; Neutrophils; Phytotherapy; Plant Extracts; Plant Structures; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Sterols; Tetradecanoylphorbol Acetate; Triterpenes | 2005 |
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.
Topics: Apoptosis; Arachidonic Acid; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chemokine CCL2; Chemokine CCL5; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression; Humans; I-kappa B Proteins; Inflammation Mediators; Interleukin-1; Interleukin-6; Ionomycin; Membrane Proteins; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Prostaglandin-Endoperoxide Synthases; Protein Precursors; RNA, Small Interfering; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
New anti-inflammatory formulation containing Synurus deltoides extract.
Topics: Acetic Acid; Angelica; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Asteraceae; Bone Marrow Cells; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Edema; Glucosamine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Pain; Plant Extracts; Prostaglandin D2; Tetradecanoylphorbol Acetate | 2005 |
Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Membrane; Cells, Cultured; Enzyme Activation; Mice; Mice, Knockout; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neuropeptides; Neutrophils; Phospholipases A; Phospholipases A2; Phosphoproteins; Protein Kinase C-epsilon; Protein Transport; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RAC2 GTP-Binding Protein; Superoxides; Tetradecanoylphorbol Acetate | 2006 |
Presynaptic effects of anandamide and WIN55,212-2 on glutamatergic nerve endings isolated from rat hippocampus.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoxazines; Calcimycin; Calcium Channel Blockers; Capsaicin; Endocannabinoids; Glutamates; Hippocampus; Male; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; Tetradecanoylphorbol Acetate | 2006 |
Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biflavonoids; Catechin; Dinoprostone; Drug Synergism; Ear; Edema; Female; Gallic Acid; Inflammation; Interleukin-1; Interleukin-6; Leukotriene B4; Lipoxygenase; Mice; Prostaglandin-Endoperoxide Synthases; Sulindac; Tea; Tetradecanoylphorbol Acetate | 2006 |
Effect of five triterpenoid compounds isolated from root bark of Aralia elata on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of p47(phox), p67(phox), and rac to cell membrane in human neutrophils.
Topics: Arachidonic Acid; Aralia; Cell Membrane; Cells, Cultured; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Humans; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Plant Bark; rac GTP-Binding Proteins; Serine; Superoxides; Tetradecanoylphorbol Acetate; Threonine; Triterpenes; Tyrosine | 2006 |
Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Betulinic Acid; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Myrtaceae; Otitis Externa; Pentacyclic Triterpenes; Plant Leaves; Polycyclic Compounds; Sulfonamides; Tetradecanoylphorbol Acetate; Triterpenes | 2006 |
Antioxidative and acute antiinflammatory effects of Torreya grandis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonic Acid; Biphenyl Compounds; Cell Survival; Dose-Response Relationship, Drug; Edema; Fibroblasts; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred ICR; Phytotherapy; Picrates; Plant Extracts; Seeds; Superoxides; Taxaceae; Tetradecanoylphorbol Acetate | 2006 |
Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprostone; Dose-Response Relationship, Drug; Edema; Eicosanoids; Interferon-gamma; Ionophores; Leukotriene B4; Lipopolysaccharides; Macrophages; Male; Mangifera; Mice; Mice, Inbred Strains; Phytotherapy; Plant Bark; Plant Extracts; Tetradecanoylphorbol Acetate | 2006 |
Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha.
Topics: Animals; Arachidonic Acid; Calcimycin; Calcium; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Group IV Phospholipases A2; Humans; Hydrogen Peroxide; Indoles; Ionophores; Maleimides; Mice; Phospholipases A; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Pyrimidines; Pyrrolidines; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection | 2006 |
In-vitro and in-vivo anti-inflammatory action of the ethanol extract of Trachelospermi caulis.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Cell Line; Edema; Ethanol; Furans; Glucosides; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pain; Plant Extracts; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2007 |
Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Cotton Fiber; Dalbergia; Ear, External; Edema; Ethanol; Female; Granuloma; Histamine; Male; Mice; Plant Bark; Plant Extracts; Rats; Rats, Wistar; Serotonin; Solvents; Tetradecanoylphorbol Acetate; Turpentine | 2007 |
Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells.
Topics: Arachidonic Acid; Blotting, Western; Carbazoles; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Gene Expression; Green Fluorescent Proteins; Humans; Indoles; Isoenzymes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Transfection | 2007 |
Control of cyclic AMP concentration in bovine endometrial stromal cells by arachidonic acid.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Animals; Arachidonic Acid; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Cyclooxygenase 2; Depression, Chemical; Dinoprostone; Endometrium; Female; Indoles; Maleimides; Paracrine Communication; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Kinase C; Stromal Cells; Tetradecanoylphorbol Acetate | 2007 |
Effects of naturally occurring dihydroflavonols from Inula viscosa on inflammation and enzymes involved in the arachidonic acid metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Survival; Dinoprostone; Edema; Female; Flavonols; Histamine Release; Humans; In Vitro Techniques; Inflammation; Inula; Leukocyte Elastase; Leukotriene B4; Mice; Neutrophils; Peroxidase; Phospholipases A; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 2007 |
Adenosine inhibits the release of arachidonic acid and its metabolites (AAM) in activated human peripheral mononuclear cells.
Topics: Adenosine; Arachidonic Acid; Calcimycin; Calcium; Cyclic AMP; Humans; In Vitro Techniques; Ionophores; Monocytes; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Tetradecanoylphorbol Acetate | 2007 |
Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Benzophenanthridines; Calcium; Carbazoles; Cell Size; Cytochrome b Group; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Fibroblasts; Hypotonic Solutions; Lysophospholipids; Mice; NADPH Oxidase 4; NADPH Oxidases; NIH 3T3 Cells; Onium Compounds; Osmotic Pressure; Phosphoproteins; Protein Kinase C; rac1 GTP-Binding Protein; Reactive Oxygen Species; RNA Interference; Taurine; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 2008 |
Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages.
Topics: Animals; Arachidonic Acid; Benzoquinones; Calcimycin; Calcium; Carcinogens; Cytosol; Enzyme Activation; Enzyme Inhibitors; Female; Golgi Apparatus; Green Fluorescent Proteins; Group IV Phospholipases A2; HSP90 Heat-Shock Proteins; Immunoblotting; Immunoprecipitation; Ionophores; Lactams, Macrocyclic; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 10; NIH 3T3 Cells; Okadaic Acid; Phosphoamino Acids; Phosphorylation; Protein Transport; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Zymosan | 2008 |
Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes.
Topics: Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytokines; Humans; Monocytes; Tetradecanoylphorbol Acetate | 2008 |
Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots.
Topics: Alkanes; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Asteraceae; Ear, External; Edema; Ethanol; Indicators and Reagents; Inflammation; Mice; Plant Extracts; Plant Roots; Polyunsaturated Alkamides; Solvents; Tetradecanoylphorbol Acetate | 2009 |
RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Base Sequence; Binding Sites; Blood Platelets; Cell Line, Tumor; Chromatin Immunoprecipitation; Consensus Sequence; Core Binding Factor Alpha 2 Subunit; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genes, Reporter; Haploidy; Humans; Leukemia, Erythroblastic, Acute; Luciferases; Molecular Sequence Data; Platelet Activation; Promoter Regions, Genetic; Protein Binding; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Thrombin | 2010 |
Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Baccharis; Capsaicin; Dermatitis, Contact; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Ear; Edema; Male; Mice; Neutrophil Infiltration; Oleanolic Acid; Plant Leaves; Plant Preparations; Stigmasterol; Tetradecanoylphorbol Acetate | 2010 |
Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-kappaB nuclear localization.
Topics: Animals; Arachidonic Acid; Cells, Cultured; Croton Oil; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dermatitis; Dinoprostone; Down-Regulation; Edema; Humans; Inflammation Mediators; Isoflavones; Mice; Mice, Hairless; Mitogen-Activated Protein Kinases; NF-kappa B; Reactive Oxygen Species; Skin; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 2010 |
Anti-inflammatory activity of an alkaloid from Solanum trilobatum on acute and chronic inflammation models.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Edema; India; Inflammation; Leukocytes; Neutrophils; Rats; Rats, Wistar; Solanaceous Alkaloids; Solanum; Tetradecanoylphorbol Acetate | 2011 |
Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils.
Topics: Arachidonic Acid; Cell Membrane; Cells, Cultured; Gentiana; Humans; Iridoid Glucosides; Iridoids; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Plant Roots; Protein Transport; Pyrones; Superoxides; Tetradecanoylphorbol Acetate | 2012 |
15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Arachidonic Acid; Calcimycin; Cell Proliferation; Chromans; Dinoprost; Dinoprostone; Gene Expression; Ionophores; Isoenzymes; Lipid Metabolism; Mice; NF-kappa B; PPAR gamma; Proline; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate; Thiazolidinediones; Thiocarbamates; Triglycerides; Troglitazone | 2011 |
Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Carcinogens; Curcumin; Dermatitis; Ear, External; Edema; Female; Ketones; Mice; Mice, Inbred Strains; Platelet Aggregation Inhibitors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 2011 |
Contact sensitizers modulate the arachidonic acid metabolism of PMA-differentiated U-937 monocytic cells activated by LPS.
Topics: Arachidonic Acid; Cell Differentiation; Haptens; Humans; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Monocytes; Tetradecanoylphorbol Acetate; U937 Cells | 2011 |
Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue.
Topics: Animals; Aquatic Organisms; Arachidonic Acid; Butylated Hydroxytoluene; Cell Extracts; Cell Line, Tumor; Chromatography, Liquid; Cysteine; Gracilaria; Humans; Male; Mice; Oxidation-Reduction; Prostaglandin D2; Prostaglandins; Spectrum Analysis; Sulfhydryl Compounds; Tandem Mass Spectrometry; Tetradecanoylphorbol Acetate | 2011 |
Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes.
Topics: Animals; Arachidonic Acid; Dermatitis; Ethanol; Flow Cytometry; Hypersensitivity, Delayed; Male; Mice; Plant Extracts; Tetradecanoylphorbol Acetate; Veronica | 2011 |
Prostaglandin modulation of phorbol ester skin tumor promotion.
Topics: Animals; Arachidonic Acid; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dinoprost; Dinoprostone; Female; Mice; Mice, Inbred SENCAR; Oxytocics; Papilloma; Prostaglandins; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Antiinflammatory, analgesic and antioxidant activities of Cyathula prostrata (Linn.) Blume (Amaranthaceae).
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Behavior, Animal; Biphenyl Compounds; Carrageenan; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Inflammation; Inflammation Mediators; Lipid Peroxidation; Lipopolysaccharides; Macrophages; Male; Methanol; Mice; Motor Activity; Nitric Oxide; Oxidative Stress; Pain; Pain Threshold; Phytotherapy; Picrates; Plant Preparations; Plants, Medicinal; Rats; Rats, Wistar; Reactive Oxygen Species; Solvents; Tetradecanoylphorbol Acetate; U937 Cells; Xylenes | 2012 |
Platelet-neutrophil aggregate formation in blood samples from dogs with systemic inflammatory disorders.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Collagen; Dog Diseases; Dogs; Epinephrine; Female; Flow Cytometry; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Neutrophil Activation; Neutrophils; Platelet Aggregation; Prospective Studies; Statistics, Nonparametric; Systemic Inflammatory Response Syndrome; Tetradecanoylphorbol Acetate | 2012 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indomethacin; Inflammation; Male; Mice; Monoterpenes; Oils, Volatile; Origanum; Rats; Rats, Wistar; Ruthenium Red; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate | 2012 |
Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Ionomycin; Ketones; Mice; Neurons; Peptide Fragments; Phospholipases A2, Cytosolic; Prions; Protein Transport; Synaptophysin; Tetradecanoylphorbol Acetate; Time Factors; Tritium; Tubulin | 2012 |
Combretum leprosum Mart. (Combretaceae): potential as an antiproliferative and anti-inflammatory agent.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line; Cell Proliferation; Combretum; Croton Oil; Dermatitis, Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Ear; Edema; Ethanol; Female; Flowers; Interleukin-6; Mice; Peroxidase; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Skin; Tetradecanoylphorbol Acetate | 2013 |
Arachidonic acid enhances TPA-induced differentiation in human leukemia HL-60 cells via reactive oxygen species-dependent ERK activation.
Topics: Arachidonic Acid; Cell Differentiation; Extracellular Signal-Regulated MAP Kinases; HL-60 Cells; Humans; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2013 |
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Calcium; Cell Line, Tumor; Glioma; Histamine; Inositol Phosphates; Pyrilamine; Rats; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 2013 |
Anti-inflammatory activity and phenolic profile of propolis from two locations in Región Metropolitana de Santiago, Chile.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Cell Line; Cell Survival; Chile; Complex Mixtures; Edema; Flavonoids; Male; Mice; Nitric Oxide; Phenols; Propolis; Tetradecanoylphorbol Acetate | 2015 |
Synthesis, Anti-inflammatory Activities and Mechanisms of 3,5- dihydroxycinnamic Acid Derivatives.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Calcimycin; Cell Line; Cell Line, Tumor; Cell Survival; Cinnamates; Cyclooxygenase 2; Cytokines; Dinoprostone; Ear; Edema; Female; Lipopolysaccharides; Lipoxygenase Inhibitors; Mice, Inbred BALB C; Peroxidase; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 2015 |
Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Capillary Permeability; Carrageenan; Coumaric Acids; Cytokines; Dinoprostone; Ear; Edema; Female; Foot; Leukotriene B4; Male; Mice; Monosaccharides; Neutrophils; Opuntia; Peritonitis; Phospholipases A2; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2016 |
Swelling-activated and arachidonic acid-induced currents are TREK-1 in rat bladder smooth muscle cells.
Topics: Animals; Arachidonic Acid; Colforsin; Hydrogen-Ion Concentration; Male; Membrane Potentials; Muscle, Smooth; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Urinary Bladder | 2016 |
Ceruloplasmin-derived peptide is the strongest regulator of oxidative stress and leukotriene synthesis in neutrophils.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Carcinogens; Ceruloplasmin; Humans; Leukotriene B4; Neutrophils; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Phagocytosis; Salmonella typhimurium; Tetradecanoylphorbol Acetate | 2017 |
Comparison of the anti-inflammatory effects of Sinapis alba and Brassica juncea in mouse models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; China; Edema; Inflammation; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mustard Plant; Peroxidase; Plant Extracts; Seeds; Sinapis; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2018 |
Preclinical study of the topical anti-inflammatory activity of Cyperus rotundus L. extract (Cyperaceae) in models of skin inflammation.
Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Atrophy; Cell Proliferation; Cyperus; Dermatitis, Contact; Edema; Female; Irritants; Keratinocytes; Lymph Nodes; Mice; Phytochemicals; Phytotherapy; Plant Extracts; Rhizome; Skin; Spleen; Tetradecanoylphorbol Acetate; Thymus Gland | 2020 |
The Trace Element Selenium Is Important for Redox Signaling in Phorbol Ester-Differentiated THP-1 Macrophages.
Topics: Arachidonic Acid; Cell Differentiation; Cell Line; Eicosapentaenoic Acid; Humans; Lipopolysaccharides; Macrophages; NF-kappa B; Oxidation-Reduction; Phospholipid Hydroperoxide Glutathione Peroxidase; Selenium; Selenoproteins; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxane B2 | 2021 |