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tetradecanoylphorbol acetate and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

tetradecanoylphorbol acetate has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 75 studies

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's25 (33.33)18.2507
2000's39 (52.00)29.6817
2010's11 (14.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Chang, FR; Chen, BH; Chen, SL; Cheng, YB; Hsu, HY; Hsu, YM; Hwang, TL; Korinek, M; Lo, IW; Wagh, VD; Wu, YC1
Badwey, JA; Brown, RF; Ding, J; Liu, R; Vlahos, CJ1
Navé, BT; Shepherd, PR; Siddle, K1
Araki, N; Johnson, MT; Swanson, JA1
Dong, Z; Huang, C; Ma, WY; Schmid, HH; Schmid, PC1
al-Hassani, M; Natarajan, V; Scribner, WM; Vepa, S1
Boulougouris, G; Parry, RV; Sansom, DM; Ward, SG1
Butler, J; Downey, GP; Fialkow, L; Grinstein, S; Schelm, JA; Sue-A-Quan, AK; Vlahos, CJ1
Katagiri, Y; Nakamura, M; Nakashima, S; Nozawa, Y1
Fukuda, K; Kato, S; Mori, K; Morikawa, H; Shoda, T1
Alblas, J; Dufourny, B; Steenbergh, PH; Sussenbach, JS; van der Burg, B; van Schaik, FM; van Teeffelen, HA1
Conway, AM; Pyne, NJ; Pyne, S1
Kerr, MA; Lang, ML1
Capodici, C; Feoktistov, M; Hanft, S; Pillinger, MH1
Bragado, MJ; Groblewski, GE; Williams, JA1
Alessi, DR; Cohen, P; Le Good, JA; Parekh, DB; Parker, PJ; Ziegler, WH1
Solem, ML; Thomas, AP1
Lan, L; Wong, NS1
Shibuya, M; Takahashi, T; Ueno, H1
Piper, HM; Schäfer, M; Schlüter, KD; Simm, A; Taimor, G1
Nishioka, M; Okumura, K; Sasazuki, T; Shirasawa, S1
Akasaki, T; Koga, H; Sumimoto, H1
Babià, T; De Matteis, MA; di Campli, A; Egea, G; Luini, A; Valderrama, F1
Moelling, K; Zimmermann, S1
Bácsy, E; Bander, E; Buday, L; Faragó, A; Farkas, G; Sipeki, S; Ways, DK1
Côté, S; Gingras, S; Simard, J1
Chiles, K; Feldser, D; Georgescu, MM; Hanrahan, C; Laughner, E; Semenza, GL; Simons, JW; Zhong, H1
Chung, J; Jung, Y; Kim, D; Kim, S; Koh, H1
Baumgarten, CM; Dent, P; Fan, S; Gao, B; He, L; Kunos, G; Nguyen, VA; Sheng, X; Spector, M; Woodward, J1
Dufourny, B; Hamelers, IH; Steenbergh, PH; Sussenbach, JS1
Chen, HC; Liang, CC1
Clerk, A; Cole, SM; Pham, FH1
An, NH; Cha, JG; Kim, HM; Kim, MS; Lee, YM; Lim, WK; Park, JH; Yoo, SJ1
An, NH; Baek, SH; Jeung, JY; Kim, HM; Kim, NS; Lee, KN; Oh, GJ; Park, ST; Song, YS; Yim, HG; Yoon, HS1
Asano, Y; Ishibashi, S; Miyata, Y; Muto, S; Okada, K1
Cholidis, S; Hartmann, C; Rieck, PW1
Baker, RC; Farley, JM; Mamoon, AM1
Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP1
Bandyopadhyay, A; Choi, HS; Chung, J; Im, WB; Ju, JW; Kwon, HB1
Hong, SH; Kim, HM; Lee, SC; Park, SJ1
Aizawa, T; Hashizume, K; Iijima, S; Nakajima, K; Shigematsu, S; Yamauchi, K1
Kang, SY; Kim, HM; Kim, NS; Park, SJ1
Alrefai, WA; Dudeja, PK; Gill, RK; Ramaswamy, K; Saksena, S; Syed, IA; Tyagi, S1
Gliki, G; Wheeler-Jones, C; Zachary, I1
Baraban, JM; Beretta, L; Dy, M; Grolleau, A; Machavoine, F; Rolli-Derkinderen, M1
Banerji, L; Glassford, J; Holman, M; Kadowaki, T; Klaus, GG; Koyasu, S; Lam, EW; Skarell, SM; Soeiro, I1
Dinh, DH; Gujrati, M; Gumidyala, KV; Mohanam, S; Olivero, WC; Rao, JS; Waldron, KG; Yanamandra, N1
Kim, SG; Kim, SO1
Aeder, SE; Hussaini, IM; Martin, PM; Soh, JW1
Chang, J; Combs, CA; Huang, W; Ishii, I; Jones, NL; Kruth, HS; Malide, D; Zhang, WY; Zhao, B1
Hadjab, S; Hans, G; Lallemend, F; Lefebvre, PP; Malgrange, B; Moonen, G1
Clerk, A; Markou, T; Sugden, PH; Yong, CS1
Dixon, DA; Haglund, C; Hallikainen, T; Heinonen, M; Hemmes, A; Rintahaka, J; Ristimäki, A; Thiel, A1
Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T1
Denkert, C; Dietel, M; Kaszubiak, A; Koch, I; Lage, H; Niesporek, S; Noske, A; Schaefer, B; Sehouli, J; Sers, C; Weichert, W1
Barragán, M; Campàs, C; Castaño, E; Coll-Mulet, L; Cosialls, AM; de Frias, M; Domingo, A; Gil, J; Iglesias-Serret, D; Pons, G; Santidrián, AF1
Magnusson, KE; Navakauskiene, R; Pivoriūnas, A; Savickiene, J; Treigyte, G; Tunaitis, V1
Ammer, A; Cao, Z; Clump, AC; Flynn, DC; Jiang, BH; Kelley, LC; Walker, VG; Weed, SA; Zot, H1
De Fazio, SR; Warner, CM1
Ahmed, A; Cudmore, MJ; Findley, CM; Kontos, CD1
Herness, S; Zhao, FL1
Cao, J; Chen, W; Dai, B; Lin, D; Liu, L; Liu, Y; Ma, D; Sun, Y; Yu, H1
Fujikake, T; Fujioka, K; Hanamoto, T; Ikeda, T; Ishizuka, T; Kajita, K; Mori, I; Morita, H; Nagano, I; Okada, H; Takahashi, Y; Uno, Y; Zhiliang, W1
Alrefai, WA; Annaba, F; Dwivedi, A; Gill, RK; Saksena, S; Sarwar, Z1
Khattar, E; Kumar, V1
Chrysanthopoulou, A; Kambas, K; Kourtzelis, I; Mitroulis, I; Rafail, S; Ritis, K; Speletas, M1
Hokello, J; Karn, J; Kim, YK; Mbonye, U1
Chae, JI; Cho, JH; Cho, MK; Kim, DJ; Lee, KA; Lee, SH; Nam, HS; Shim, JH; Woo, KM1
Harada, T; Itamochi, H; Kawaguchi, W; Kigawa, J; Kudoh, A; Naniwa, J; Nonaka, M; Oishi, T; Sato, S; Shimada, M; Terakawa, N; Uegaki, K1
Furue, MK; Hirata, M; Hirayama, N; Kawamura, S; Kinehara, M; Kohara, A; Matsumura, H; Mimura, S; Suga, M; Tateyama, D; Uchio-Yamada, K; Yanagihara, K1
DiGiovanni, J; Jiang, G; Kiguchi, K; Rho, O1
Angel, J; Busca, A; Iqbal, S; Kumar, A; Saxena, M1
Bongartz, H; Eulenfeld, R; Feller, SM; Hessenkemper, W; Lievens, S; Schaper, F; Simister, PC; Tavernier, J; Wolf, A1
Hung, HC; Liao, YF; Liu, GY; Tzeng, YM1

Other Studies

75 other study(ies) available for tetradecanoylphorbol acetate and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Inflammation Modulatory Phorbol Esters from the Seeds of Aquilaria malaccensis.
    Journal of natural products, 2017, 05-26, Volume: 80, Issue:5

    Topics: Anti-Inflammatory Agents; Glycerides; Humans; Molecular Structure; Neutrophils; Phorbol Esters; Seeds; Thymelaeaceae

2017
Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils.
    The Journal of biological chemistry, 1995, May-12, Volume: 270, Issue:19

    Topics: Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Kinetics; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protamine Kinase; Protein Denaturation; Protein Kinase Inhibitors; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

1995
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
    The Biochemical journal, 1996, Aug-15, Volume: 318 ( Pt 1)

    Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Biological Transport; Blotting, Western; Chromones; Enzyme Inhibitors; Glucose; Insulin; Insulin Antagonists; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Precipitin Tests; Tetradecanoylphorbol Acetate; Wortmannin

1996
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.
    The Journal of cell biology, 1996, Volume: 135, Issue:5

    Topics: Androstadienes; Animals; Cell Membrane; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; Fluorescent Dyes; Lysosomes; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Inbred C3H; Morpholines; Organelles; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Pinocytosis; Pseudopodia; Receptors, Fc; Tetradecanoylphorbol Acetate; Wortmannin

1996
Phosphatidylinositol-3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation.
    The Journal of biological chemistry, 1997, Feb-14, Volume: 272, Issue:7

    Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Insulin; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Wortmannin

1997
The enhancement by wortmannin of protein kinase C-dependent activation of phospholipase D in vascular endothelial cells.
    Chemistry and physics of lipids, 1997, Mar-28, Volume: 86, Issue:1

    Topics: Androstadienes; Animals; Cattle; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Genistein; Glycerophospholipids; Isoenzymes; Isoflavones; Morpholines; Oxidants; Phosphatidic Acids; Phosphodiesterase Inhibitors; Phospholipase D; Phosphorus Radioisotopes; Protein Kinase C; Sensitivity and Specificity; Tetradecanoylphorbol Acetate; Wortmannin

1997
Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase.
    Biochemical Society transactions, 1997, Volume: 25, Issue:2

    Topics: Androstadienes; Antibodies, Monoclonal; Antigens, CD; CD28 Antigens; CD3 Complex; Chromones; Enzyme Inhibitors; Humans; Jurkat Cells; Lymphocyte Activation; Morpholines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin

1997
Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases.
    Journal of cellular physiology, 1997, Volume: 172, Issue:1

    Topics: Androstadienes; Antigens, CD; Antigens, Neoplasm; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules; Cell Degranulation; Cells, Cultured; Chromones; Enzyme Inhibitors; Humans; MAP Kinase Kinase 1; Membrane Glycoproteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Platelet Membrane Glycoproteins; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Tetraspanin 30; Wortmannin

1997
Effect of wortmannin and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: possible involvement of phosphatidylinositol 3-kinase in phosp
    Biochemical pharmacology, 1997, Jun-15, Volume: 53, Issue:12

    Topics: Androstadienes; Cell Differentiation; Cell Membrane; Chromones; Enzyme Activation; HL-60 Cells; Humans; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Tetradecanoylphorbol Acetate; Wortmannin

1997
Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells.
    FEBS letters, 1997, Jul-28, Volume: 412, Issue:2

    Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Chromones; Cricetinae; Cricetulus; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nociceptin Receptor; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Opioid; Recombinant Proteins; Tetradecanoylphorbol Acetate; Wortmannin

1997
Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.
    The Journal of biological chemistry, 1997, Dec-05, Volume: 272, Issue:49

    Topics: Breast Neoplasms; Cell Division; Chromones; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA Replication; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Humans; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Retinoblastoma Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1997
Sphingosine 1-phosphate activation of MAP kinase--involvement of PI 3-kinase and protein kinase C.
    Biochemical Society transactions, 1997, Volume: 25, Issue:4

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Indoles; Lysophospholipids; Maleimides; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Protein Kinase C; Respiratory System; Sphingosine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella

1997
Neutrophil Fc receptors signal through PI 3-kinase to trigger a respiratory burst.
    Biochemical Society transactions, 1997, Volume: 25, Issue:4

    Topics: Chromones; Enzyme Inhibitors; Humans; Immunoglobulin A; Immunoglobulin G; In Vitro Techniques; Kinetics; Luminescent Measurements; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Receptors, Fc; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate

1997
Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated, CD11b/CD18-dependent cell-cell adhesion of human neutrophils: evidence for an ERK-independent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Feb-15, Volume: 160, Issue:4

    Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; Cell Adhesion; Cell Aggregation; Cell Line, Transformed; Chromones; Complement C5a; Endothelium, Vascular; Epitopes; Humans; Ionophores; Macrophage-1 Antigen; Morpholines; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; Up-Regulation; Wortmannin

1998
Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
    Gastroenterology, 1998, Volume: 115, Issue:3

    Topics: Androstadienes; Animals; Bombesin; Carbachol; Carrier Proteins; Cholecystokinin; Chromones; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Kinetics; Male; Methionine; Morpholines; Pancreas; Peptide Initiation Factors; Phosphoproteins; Polyenes; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sirolimus; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Wortmannin

1998
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
    Science (New York, N.Y.), 1998, Sep-25, Volume: 281, Issue:5385

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Binding Sites; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; Isoenzymes; Morpholines; Phosphatidylcholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphatidylserines; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Serine-Threonine Kinases; Recombinant Proteins; Tetradecanoylphorbol Acetate

1998
Modulation of cardiac Ca2+ channels by IGF1.
    Biochemical and biophysical research communications, 1998, Nov-09, Volume: 252, Issue:1

    Topics: Animals; Calcium; Calcium Channels; Carbazoles; Cells, Cultured; Chromones; Cytosol; Enzyme Inhibitors; Heart; Humans; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Male; Manganese; Morpholines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sarcolemma; Sulfonamides; Tetradecanoylphorbol Acetate

1998
Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor.
    FEBS letters, 1999, Feb-05, Volume: 444, Issue:1

    Topics: Alkaloids; Androstadienes; Apoptosis; Benzophenanthridines; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Chromatin; Chromones; DNA Fragmentation; Enzyme Precursors; Epidermal Growth Factor; Flow Cytometry; Humans; Indoles; Maleimides; Molecular Weight; Morpholines; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Poly(ADP-ribose) Polymerases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

1999
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
    Oncogene, 1999, Apr-01, Volume: 18, Issue:13

    Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

1999
Early response kinase and PI 3-kinase activation in adult cardiomyocytes and their role in hypertrophy.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbon Radioisotopes; Carcinogens; Cardiomegaly; Cells, Cultured; Chromones; Creatine Kinase; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Genistein; Heart Ventricles; Indoles; Isoenzymes; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle Fibers, Skeletal; Myocardium; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Wortmannin

1999
Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.
    Cancer research, 1999, May-15, Volume: 59, Issue:10

    Topics: Alleles; Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colonic Neoplasms; Culture Media, Serum-Free; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Immediate-Early; Genes, ras; Humans; Indoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Mutation, Missense; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Isoforms; Protein Kinase C; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils.
    The Journal of biological chemistry, 1999, Jun-18, Volume: 274, Issue:25

    Topics: Androstadienes; Chromones; Enzyme Activation; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Indoles; Leukotriene B4; Maleimides; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Serine-Threonine Kinases; rac GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wortmannin

1999
Morphological changes in the Golgi complex correlate with actin cytoskeleton rearrangements.
    Cell motility and the cytoskeleton, 1999, Volume: 43, Issue:4

    Topics: Actins; Androstadienes; Animals; Biological Transport; Brefeldin A; Cell Membrane; Chromones; Cytochalasin D; Cytoskeleton; Depsipeptides; Enzyme Inhibitors; Epidermal Growth Factor; Glycosaminoglycans; Golgi Apparatus; Lysophospholipids; Morpholines; Nucleic Acid Synthesis Inhibitors; Peptides, Cyclic; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Wortmannin

1999
Phosphorylation and regulation of Raf by Akt (protein kinase B).
    Science (New York, N.Y.), 1999, Nov-26, Volume: 286, Issue:5445

    Topics: Cell Division; Cell Line; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; MAP Kinase Signaling System; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; ras Proteins; Recombinant Fusion Proteins; Signal Transduction; Somatomedins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1999
Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering.
    Cellular signalling, 1999, Volume: 11, Issue:12

    Topics: Carcinoma, Hepatocellular; Cell Movement; Chromones; Cycloheximide; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitin-Protein Ligases

1999
Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:2

    Topics: Androstadienes; Breast Neoplasms; Chromones; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Interleukin-4; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Progesterone Reductase; Signal Transduction; STAT6 Transcription Factor; Steroid Isomerases; Tetradecanoylphorbol Acetate; Trans-Activators; Tumor Cells, Cultured; Wortmannin

2000
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.
    Cancer research, 2000, Mar-15, Volume: 60, Issue:6

    Topics: Carrier Proteins; Chromones; Culture Media, Serum-Free; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunophilins; Lymphokines; Male; Morpholines; Neovascularization, Pathologic; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway.
    The Journal of biological chemistry, 2000, Aug-25, Volume: 275, Issue:34

    Topics: 3T3 Cells; Androstadienes; Animals; Chromones; COS Cells; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; Wortmannin; Zinc

2000
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
    Experimental cell research, 2000, Jul-10, Volume: 258, Issue:1

    Topics: Adrenergic alpha-Agonists; Androstadienes; Cell Cycle; Chemotaxis; Chromones; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured; Wortmannin

2000
Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.
    The Journal of endocrinology, 2000, Volume: 166, Issue:2

    Topics: Blotting, Northern; Blotting, Western; Breast Neoplasms; Chromones; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; Estradiol; Female; Gene Expression; Half-Life; Humans; Insulin-Like Growth Factor I; Morpholines; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2000
Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha 2 expression that is involved in cell scattering.
    The Journal of biological chemistry, 2001, Jun-15, Volume: 276, Issue:24

    Topics: Animals; Antigens, CD; Cell Adhesion; Cell Line; Cell Movement; Chromones; Cycloheximide; Dogs; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hepatocyte Growth Factor; Humans; Integrin alpha2; Integrins; Kidney; Kinetics; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Receptors, Collagen; Recombinant Proteins; Tetradecanoylphorbol Acetate

2001
Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.
    Advances in enzyme regulation, 2001, Volume: 41

    Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Carcinogens; Carrier Proteins; Chromones; Electrophoresis, Gel, Two-Dimensional; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hypertrophy; Insulin; Intracellular Signaling Peptides and Proteins; Morpholines; Myocardium; Oxidative Stress; Peptide Initiation Factors; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors

2001
The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells.
    Cancer letters, 2001, Sep-28, Volume: 171, Issue:1

    Topics: Cell Differentiation; Chromones; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Protein Kinase C; Tetradecanoylphorbol Acetate

2001
Phosphatidylinositol 3-kinase regulates proliferation of RAW 264.7 macrophages.
    Immunopharmacology and immunotoxicology, 2001, Volume: 23, Issue:3

    Topics: Androstadienes; Animals; Cell Cycle; Cell Division; Cell Line; Chromones; Enzyme Inhibitors; Gene Expression; Genes, fos; Genes, jun; Macrophages; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Wortmannin

2001
P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.
    American journal of physiology. Renal physiology, 2002, Volume: 282, Issue:1

    Topics: Actin Cytoskeleton; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Carcinogens; Chromones; Colchicine; Cyclosporine; Cytochalasin B; Diuretics, Osmotic; Enzyme Inhibitors; Hypertonic Solutions; Kidney Tubules, Proximal; Male; Mannitol; Mice; Mice, Knockout; Microtubules; Morpholines; Naphthalenes; Phorbols; Phosphatidylinositol 3-Kinases; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil; Wortmannin

2002
Intracellular signaling pathway of FGF-2-modulated corneal endothelial cell migration during wound healing in vitro.
    Experimental eye research, 2001, Volume: 73, Issue:5

    Topics: Acetophenones; Analysis of Variance; Animals; Bromodeoxyuridine; Cattle; Cell Communication; Cell Movement; Cells, Cultured; Chromones; Culture Media, Serum-Free; Endothelium, Corneal; Fibroblast Growth Factor 2; Indomethacin; Masoprocol; Morpholines; Normal Distribution; Pertussis Toxin; Piperazine; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella; Wound Healing

2001
Activation of phospholipase D in porcine tracheal smooth muscle: role of phosphatidylinositol 3-kinase and RhoA activation.
    European journal of pharmacology, 2001, Dec-14, Volume: 433, Issue:1

    Topics: Acetylcholine; Amides; Androstadienes; Animals; Calcium; Chromones; Enzyme Activation; In Vitro Techniques; Male; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phospholipase D; Pyridines; rhoA GTP-Binding Protein; Swine; Tetradecanoylphorbol Acetate; Trachea; Wortmannin

2001
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.
    Platelets, 2001, Volume: 12, Issue:8

    Topics: Adenosine Diphosphate; Androstadienes; Calcimycin; Calcium Signaling; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Indoles; Ionophores; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxanes; Type C Phospholipases; Wortmannin

2001
Involvement of phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii.
    General and comparative endocrinology, 2002, Volume: 126, Issue:2

    Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Female; Mitogen-Activated Protein Kinases; Morpholines; Oocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Progesterone; Ranidae; Ribosomal Protein S6 Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin

2002
Degradation of IkappaBalpha in activated RAW264.7 cells is blocked by the phosphatidylinositol 3-kinase inhibitor LY294002.
    Cell biology and toxicology, 2002, Volume: 18, Issue:2

    Topics: Animals; Base Sequence; Blotting, Western; Cell Line; Chromones; DNA Primers; DNA-Binding Proteins; Hydrolysis; I-kappa B Proteins; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Morpholines; NF-KappaB Inhibitor alpha; Nitric Oxide; Phosphoinositide-3 Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2002
IGF-1 regulates migration and angiogenesis of human endothelial cells.
    Endocrine journal, 1999, Volume: 46 Suppl

    Topics: Androstadienes; Cell Movement; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glucose; Humans; Insulin-Like Growth Factor I; Morpholines; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Wortmannin

1999
Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells.
    Immunopharmacology and immunotoxicology, 2002, Volume: 24, Issue:2

    Topics: Androstadienes; Apoptosis; Bucladesine; Cell Differentiation; Cell Division; Chromones; Colforsin; Enzyme Inhibitors; HL-60 Cells; Humans; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases, 70-kDa; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

2002
Inhibition of apical Cl-/OH- exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon.
    American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:5

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Androstadienes; Biological Transport; Caco-2 Cells; Carcinogens; Chloride-Bicarbonate Antiporters; Chlorides; Chromones; Enzyme Inhibitors; Humans; Insulin Receptor Substrate Proteins; Isoenzymes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Wortmannin

2002
Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3'-kinase-mediates PKC delta phosphorylation: role of PKC in angiogenesis.
    Cell biology international, 2002, Volume: 26, Issue:9

    Topics: Androstadienes; Carcinogens; Chromones; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Lymphokines; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetradecanoylphorbol Acetate; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

2002
ERK and p38 inhibit the expression of 4E-BP1 repressor of translation through induction of Egr-1.
    The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21

    Topics: Adaptor Proteins, Signal Transducing; Base Sequence; Blotting, Northern; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chromones; Cycloheximide; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine; Histidine Decarboxylase; Humans; Hypotonic Solutions; Immediate-Early Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphoserine; Promoter Regions, Genetic; Repressor Proteins; Response Elements; RNA, Messenger; Sirolimus; Tetradecanoylphorbol Acetate; Transcription Factors

2003
BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells.
    Oncogene, 2003, Apr-17, Volume: 22, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Agammaglobulinaemia Tyrosine Kinase; Amides; Animals; Antibodies, Anti-Idiotypic; Apoptosis; B-Lymphocytes; Calcium Signaling; Carrier Proteins; Cell Cycle; Chromones; Class Ib Phosphatidylinositol 3-Kinase; Crosses, Genetic; Cyclin D2; Cyclins; Enzyme Inhibitors; Female; Imidazoles; Immunologic Deficiency Syndromes; Indoles; Ionomycin; Isoenzymes; Macromolecular Substances; Male; Maleimides; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Mutant Strains; Models, Immunological; Morpholines; Nitriles; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Subunits; Protein-Tyrosine Kinases; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Tetradecanoylphorbol Acetate; Type C Phospholipases

2003
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
    Oncogene, 2004, Mar-18, Volume: 23, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Biological Assay; Brain Neoplasms; Cathepsin B; Cell Line, Tumor; Cell Movement; Chromones; Culture Media, Conditioned; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Glioblastoma; Humans; Matrix Metalloproteinase Inhibitors; Mice; Mice, Nude; Morpholines; Neoplasms; Neovascularization, Pathologic; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A

2004
PKC downstream of Pl3-kinase regulates peroxynitrite formation for Nrf2-mediated GSTA2 induction.
    Archives of pharmacal research, 2004, Volume: 27, Issue:7

    Topics: Animals; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Activation; Glutathione Transferase; Hepatocytes; Hydroquinones; Immunoblotting; Molsidomine; Morpholines; NF-E2-Related Factor 2; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Trans-Activators

2004
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
    Oncogene, 2004, Dec-02, Volume: 23, Issue:56

    Topics: Brain Neoplasms; Cell Cycle; Chromones; Enzyme Inhibitors; Glioblastoma; Humans; Morpholines; Protein Kinase C; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases

2004
Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein.
    The Journal of biological chemistry, 2005, Jan-21, Volume: 280, Issue:3

    Topics: Cells, Cultured; Chromones; Endocytosis; Enzyme Inhibitors; Foam Cells; Humans; Immunohistochemistry; Lipoproteins, LDL; Macrophage Activation; Microscopy, Electron; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pinocytosis; Proton-Translocating ATPases; Tetradecanoylphorbol Acetate; Vacuoles

2005
Activation of protein kinase CbetaI constitutes a new neurotrophic pathway for deafferented spiral ganglion neurons.
    Journal of cell science, 2005, Oct-01, Volume: 118, Issue:Pt 19

    Topics: Animals; Antineoplastic Agents; Axotomy; Brain-Derived Neurotrophic Factor; Bryostatins; Butadienes; Cell Survival; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Macrolides; Morpholines; Nerve Growth Factors; Nerve Regeneration; Neurons; Neuroprotective Agents; Neurotrophin 3; Nitriles; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar; Spiral Ganglion; Tetradecanoylphorbol Acetate

2005
Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes.
    The Journal of biological chemistry, 2006, Mar-31, Volume: 281, Issue:13

    Topics: Animals; Animals, Newborn; Cell Culture Techniques; Cell Extracts; Cells, Cultured; Chromatography, Gel; Chromones; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Immunoblotting; Indoles; Maleimides; Morpholines; Myocytes, Cardiac; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C-delta; Pyrimidines; Rats; Rats, Sprague-Dawley; Solubility; Tetradecanoylphorbol Acetate; Time Factors

2006
Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells.
    The Journal of biological chemistry, 2006, Feb-24, Volume: 281, Issue:8

    Topics: Aminophenols; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Chromones; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Lithium Chloride; Maleimides; Models, Biological; Models, Statistical; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Transfection

2006
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
    The Journal of cell biology, 2006, Jan-30, Volume: 172, Issue:3

    Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins

2006
Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer.
    Cancer letters, 2007, Feb-08, Volume: 246, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromones; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Interleukin-13; Interleukin-1beta; Middle Aged; Morpholines; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Tetradecanoylphorbol Acetate

2007
Regulation of Akt/PKB by phosphatidylinositol 3-kinase-dependent and -independent pathways in B-cell chronic lymphocytic leukemia cells: role of protein kinase C{beta}.
    Journal of leukocyte biology, 2006, Volume: 80, Issue:6

    Topics: Apoptosis; Carcinogens; Chromones; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Models, Biological; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Cytokine; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

2006
PI 3-K signaling pathway suppresses PMA-induced expression of p21WAF1/Cip1 in human leukemia cells.
    Molecular and cellular biochemistry, 2007, Volume: 302, Issue:1-2

    Topics: Cell Line, Tumor; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Humans; Leukemia; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Kinases; Signal Transduction; Sirolimus; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53

2007
PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.
    American journal of physiology. Cell physiology, 2007, Volume: 293, Issue:1

    Topics: Animals; Cell Membrane; Cell Movement; Chromones; Enzyme Activation; Enzyme Activators; Fibroblasts; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Morpholines; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src Homology Domains; Tetradecanoylphorbol Acetate; Transfection

2007
Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2007, Volume: 58, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antibodies; Blastocyst; Cell Proliferation; Cells, Cultured; Chromones; Cross-Linking Reagents; Dose-Response Relationship, Drug; Female; Histocompatibility Antigens Class I; Immunoglobulins; Immunoprecipitation; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nucleosides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fyn; Pyridazines; Pyrimidines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Wortmannin

2007
VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:12

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Apoptosis; Cells, Cultured; Chromones; Dipeptides; Endothelial Cells; Fibroblasts; Humans; Imidazoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Morpholines; Neovascularization, Physiologic; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Receptor, TIE-2; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A

2007
Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
    The Journal of physiology, 2009, Jan-15, Volume: 587, Issue:2

    Topics: Androstadienes; Animals; Benzylamines; Caffeine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chromones; Delayed Rectifier Potassium Channels; Enzyme Inhibitors; Estrenes; Male; Morpholines; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C beta; Polylysine; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Sulfonamides; Taste; Taste Buds; Tetradecanoylphorbol Acetate; Wortmannin

2009
S6K1 is involved in polyploidization through its phosphorylation at Thr421/Ser424.
    Journal of cellular physiology, 2009, Volume: 219, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Antineoplastic Agents; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromones; Cyclin B; Enzyme Inhibitors; Humans; Megakaryocytes; Morpholines; Nocodazole; Phosphoproteins; Phosphorylation; Polyploidy; Protein Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sirolimus; Tetradecanoylphorbol Acetate; Threonine; TOR Serine-Threonine Kinases; Wortmannin

2009
Effects of phorbol ester-sensitive PKC (c/nPKC) activation on the production of adiponectin in 3T3-L1 adipocytes.
    IUBMB life, 2009, Volume: 61, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Carbazoles; Chromones; Enzyme Activation; Gene Expression; Glucose; Insulin; Mice; Morpholines; NF-kappa B; PPAR gamma; Protein Kinase C; Tetradecanoylphorbol Acetate; Tetrazoles; Tumor Necrosis Factor-alpha

2009
Modulation of ileal apical Na+-dependent bile acid transporter ASBT by protein kinase C.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:3

    Topics: Bile Acids and Salts; Caco-2 Cells; Calcium; Cell Membrane; Chelating Agents; Chromones; Egtazic Acid; Enzyme Activators; Humans; Ileum; Indoles; Intestinal Mucosa; Kinetics; Maleimides; Morpholines; Organic Anion Transporters, Sodium-Dependent; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Symporters; Tetradecanoylphorbol Acetate; Transfection

2009
Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors.
    The Journal of biological chemistry, 2010, Feb-12, Volume: 285, Issue:7

    Topics: Blotting, Western; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromones; Computational Biology; Cyclin-Dependent Kinase Inhibitor p27; Electrophoretic Mobility Shift Assay; Flavonoids; Flow Cytometry; Humans; MAP Kinase Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Multimerization; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1

2010
Regulation of the autophagic machinery in human neutrophils.
    European journal of immunology, 2010, Volume: 40, Issue:5

    Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hydrogen-Ion Concentration; Inflammation; Microscopy, Confocal; Morpholines; Neutrophils; Phagosomes; Poly I-C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirolimus; Small Ubiquitin-Related Modifier Proteins; Tetradecanoylphorbol Acetate; Toll-Like Receptors; Transcription, Genetic; Vacuoles

2010
T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway.
    Journal of molecular biology, 2011, Jul-29, Volume: 410, Issue:5

    Topics: Butadienes; Chromatin; Chromones; Cyclin T; Cyclin-Dependent Kinase 9; Extracellular Signal-Regulated MAP Kinases; HIV; Humans; Jurkat Cells; Kinetics; Morpholines; NFATC Transcription Factors; Nitriles; Positive Transcriptional Elongation Factor B; Protein Binding; Proviruses; Receptors, Antigen, T-Cell; Ribonucleoproteins; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Virus Activation; Virus Latency

2011
Phosphoinositol 3-kinase, a novel target molecule for the inhibitory effects of juglone on TPA-induced cell transformation.
    International journal of molecular medicine, 2012, Volume: 30, Issue:1

    Topics: Androstadienes; Animals; Cell Line; Cell Transformation, Neoplastic; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Endothelial Growth Factors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Morpholines; Naphthoquinones; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Ribosomal Protein S6 Kinases, 90-kDa; Skin; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Wortmannin

2012
Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells.
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2012, Volume: 22, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Chromones; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Female; Flavonoids; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Morpholines; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; S Phase; Tetradecanoylphorbol Acetate; Xenograft Model Antitumor Assays

2012
Protein kinase C regulates human pluripotent stem cell self-renewal.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Activins; Alkaline Phosphatase; Blotting, Western; Carbazoles; Cell Line; Cell Proliferation; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Indoles; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Pluripotent Stem Cells; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Tetradecanoylphorbol Acetate

2013
Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromones; ErbB Receptors; Female; Flavonoids; Hair Follicle; Hyperplasia; Keratinocytes; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred ICR; Mice, Transgenic; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Skin Neoplasms; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases

2014
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:6

    Topics: Anthracenes; Apoptosis; bcl-X Protein; Caffeic Acids; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Regulation, Developmental; Hematopoiesis; Humans; Macrophage Colony-Stimulating Factor; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; Tetradecanoylphorbol Acetate

2014
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
    Cellular signalling, 2015, Volume: 27, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Androstadienes; Butadienes; Cell Membrane; Chromones; HEK293 Cells; Humans; Interleukin-6; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Mutation; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Translocation, Genetic; Wortmannin

2015
Dibenzoylmethane, hydroxydibenzoylmethane and hydroxymethyldibenzoylmethane inhibit phorbol-12-myristate 13-acetate‑induced breast carcinoma cell invasion.
    Molecular medicine reports, 2015, Volume: 11, Issue:6

    Topics: Acetophenones; Benzopyrans; Breast Neoplasms; Cell Movement; Chalcones; Chromones; Female; Humans; Ketones; Matrix Metalloproteinase 9; MCF-7 Cells; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propane; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate

2015