tetradecanoylphorbol acetate has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 733 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 142 (19.37) | 18.7374 |
| 1990's | 539 (73.53) | 18.2507 |
| 2000's | 46 (6.28) | 29.6817 |
| 2010's | 6 (0.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Castrén, E; Hartikka, J; Lindholm, D; Thoenen, H; Zafra, F | 1 |
| Kotoyori, J; Kozawa, O; Miwa, M; Oiso, Y; Tokuda, H | 1 |
| Jaiswal, RK | 1 |
| Emoto, S; Ichikawa, A; Imanishi, N; Kawai, H; Ohgoh, M; Ohmori, E; Yatsunami, K | 1 |
| Hata, K; Kukita, A; Kukita, T; Kurisu, K | 1 |
| Hasuma, T; Matsui-Yuasa, I; Obayashi, M; Otani, S | 1 |
| Khan, NA; Moulinoux, JP; Quemener, V | 2 |
| Akimaru, K; Edashige, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T | 1 |
| Badwey, JA; Ding, J | 1 |
| Chase, HS; Lindeman, RP; Luo, H | 1 |
| Cragoe, EJ; Haddad, P; Haman, A; Hoang, T; Rajotte, D | 1 |
| Nobunaga, M; Shiokawa, S; Yamamoto, M; Yasuda, M | 1 |
| Corvol, P; Eckardt, KU; Fabbro, D; Kurtz, A; Pugh, C; Ratcliffe, P | 1 |
| Schultz, RM; Schwartz, DA | 1 |
| Baldassare, JJ; Burns, D; Ceska, M; Fisher, GJ; Hammerberg, C; Henderson, PA; Voorhees, JJ; Zhang, QY | 1 |
| Akimaru, K; Klostergaard, J; Sato, EF; Utsumi, K; Utsumi, T; Yoshioka, T | 1 |
| Hayashi, K | 1 |
| Kiss, Z | 1 |
| Koyama, N; Morisaki, N; Saito, Y; Yoshida, S | 1 |
| Engler, D; Funder, JW; Liu, JP; Robinson, PJ | 1 |
| Endo, Y; Furuya, S; Matsui, Y; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Suzuki, S | 1 |
| Satoh, H | 2 |
| Chadee, K; Keller, K; Olivier, M | 1 |
| Desai, SN; Letts, GL; Myers, CL; Schembri-King, J; Wallace, RW | 1 |
| Horio, T; Kohno, M; Murakawa, K; Takeda, T; Yasunari, K; Yokokawa, K | 1 |
| Estabrook, A; Fisher, PB; Gutierrez, MC; Jiang, H; Leon, JA; Waxman, S | 1 |
| Fröhlich, O; Wallert, MA | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Lea, P; Takai, A | 1 |
| Grant, DS; Kinsella, JL; Kleinman, HK; Weeks, BS | 1 |
| Friesel, RE; Peifley, KA; Winkles, JA | 1 |
| Bergstrand, H; Karabelas, K; Lundquist, B; Michelsen, P | 1 |
| Amano, S; Hanazawa, S; Kitami, H; Kitano, S; Murakami, Y; Ohta, K; Takeshita, A | 1 |
| Bargon, J; Crystal, RG; Dalemans, W; Lecocq, JP; Pavirani, A; Trapnell, BC; Yoshimura, K | 1 |
| Chakrabarty, S | 1 |
| Chao, R; Hannun, YA; Khan, W | 1 |
| Chang, KJ; Kwon, HB; Lee, CC; Schuetz, AW; Yoo, YR | 1 |
| Calle, R; Naftolin, F; Robbins, R; Tranque, PA | 1 |
| Schrier, RW; Williams, B | 1 |
| Candeo, P; Favaron, M; Lengyel, I; Manev, H; Manev, RM; Rimland, JM | 1 |
| Beauchamp, RD; Ishizuka, J; Sheng, HM; Thompson, JC; Townsend, CM | 1 |
| Datta, R; Hass, R; Kharbanda, S; Kufe, D; Nakamura, T; Rubin, E | 1 |
| Ishihara, M; Jiang, H; Kato, R; Nishikawa, K; Wang, JC; Yamamoto, S | 1 |
| Jokura, Y; Kitajima, Y; Nishizawa, Y; Owaribe, K; Yaoita, H | 1 |
| Kobayashi, T | 1 |
| Pradines-Figueres, A; Raetz, CR | 1 |
| Byrne, JH; Critz, SD | 1 |
| Bhat, NR; Hauser, KF; Kindy, MS | 1 |
| Poole, AR; Rajabi, MR; Solomon, S | 1 |
| Tsuneishi, S | 1 |
| Meltzer, M; Mufson, RA; Myers, C; Turpin, JA | 1 |
| Harada, N; Koike, T; Morikawa, M; Yoshida, T | 1 |
| Chen, LC; Ito, A; Mori, Y; Nagase, H; Ojima, Y | 1 |
| Hu, SB; Lightman, SL; Tannahill, LA | 1 |
| Alkon, DL; Etcheberrigaray, R; Lederhendler, II; Matzel, LD | 1 |
| Greer, MA; Sato, N; Wang, X | 1 |
| Anderson, L; Eidne, KA; Hoyland, J; Mason, WT | 1 |
| Baldari, CT; Macchia, G; Telford, JL | 1 |
| Becker, EL; Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI; Wang, E; Yamazaki, M | 1 |
| Amtmann, E; Doppler, C; Sauer, G; Schalasta, G | 1 |
| Ganguly, NK; Gorowara, S; Mahajan, RC; Walia, BN | 1 |
| Bouaboula, M; Casellas, P; d'Angeac, AD; Dornand, J; Favero, J; Shire, D | 1 |
| Kelleher, D; Long, A | 2 |
| Joyce, NC; Meklir, B | 1 |
| Gotlieb, AI; Yu, JC | 2 |
| Andoh, K; Gaudernack, G; Narahara, N; Pettersen, KS; Prydz, H; Wiiger, MT | 1 |
| Crews, FT; Guzman, NJ | 1 |
| Akerström, G; Gylfe, E; Hellman, P; Larsson, R; Nygren, P; Rastad, J; Ridefelt, P | 1 |
| Fujita, T; Fukase, M; Ikeda, K; Sugimoto, T | 2 |
| He, CJ; Meulders, Q; Peraldi, MN; Rebibou, JM; Rondeau, E | 1 |
| Fusamoto, H; Hayashi, N; Kamada, T; Kasahara, A; Katayama, K; Sasaki, Y; Takehara, T; Towata, T | 1 |
| Asano, K; Iizuka, H; Ito, F; Takahashi, H; Tamura, T; Tsutsui, M | 1 |
| Hurme, M; Matikainen, S; Serkkola, E | 1 |
| Hershman, JM; Murakami, S; Pang, XP; Sugawara, M; Urabe, M | 1 |
| Davis, PD; Nixon, JS; Sedgwick, AD; Wadsworth, J; Westmacott, D; Wilkinson, SE | 1 |
| Chedrese, PJ; Ly, H; Murphy, BD; Rajkumar, K | 1 |
| Gershengorn, MC; Perlman, JH | 1 |
| Ermel, B; Häring, HU; Kellerer, M; Mühlhöfer, A; Müller, HK; Obermaier-Kusser, B; Vogt, B | 1 |
| Davies, AH; Evans, FJ; Grand, RJ; Rickinson, AB | 1 |
| Charron, D; Loyau, G; Mauviel, A; Pujol, JP; Temime, N | 1 |
| Chau, LY | 1 |
| Andrade, J; Folch, H; Guarda, MI; Maldonado, C; Ojeda, F | 1 |
| Suen, CS; Wilk, S | 2 |
| Kennedy, MS; Maddon, PJ; McDougal, JS; Orloff, GM; Orloff, SL | 1 |
| Jin, N; Packer, CS; Rhoades, RA | 1 |
| Akiyama, T; Fujimoto, A; Kai, S; Kaibuchi, K; Takai, Y; Toyoshima, K; Yamamoto, T | 1 |
| Aragón, C; Casado, M; Giménez, C; Zafra, F | 1 |
| Nozawa, Y; Okano, Y; Yada, Y | 1 |
| Blanchard, LM; Larose, L; Morisset, J; Paquette, B | 1 |
| Drexler, HG; Gignac, SM; Hoffbrand, AV; Pettit, GR | 1 |
| Baldari, CT; Macchia, G; Massone, A; Telford, JL | 1 |
| Felipo, V; Grisolía, S; Miñana, MD | 1 |
| Drapeau, P | 1 |
| Gilfillan, AM; Welton, AF; Wiggan, GA | 1 |
| Bonak, V; Casnellie, JE; Huang, CK; Laramee, GR | 1 |
| Bordier, C; Cassar, G; Chiron, M; Darbon, JM; Jaffrezou, JP; Laurent, G; Roubinet, F | 1 |
| de Pont, JJ; Ederveen, AG; Van Emst-De Vries, SE; Willems, PH | 1 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y | 1 |
| Murphy, JJ; Norton, JD; Yaxley, JC | 1 |
| Ewenstein, BM; Johnson, DR; Pober, JS; Ritchie, AJ | 1 |
| Bahrami, LH; Lenhard, LW; Pandol, SJ; Perkins, PS | 1 |
| Dorf, ME; Jayaraman, S; Mensi, N; Webb, DR | 1 |
| Cinotti, GA; Menè, P; Pugliese, F | 1 |
| Haneda, M; Horide, N; Kajiwara, N; Kikkawa, R; Koya, D; Maeda, S; Shigeta, Y; Togawa, M | 1 |
| Norman-O'Guin, K; Shafit-Zagardo, B; Sharma, N | 1 |
| Fujimoto, J; Gershengorn, MC; Straub, RE | 1 |
| Kojima, I; Shibata, H | 1 |
| Alberola-Ila, J; Lozano, F; Places, L; Vives, J | 1 |
| Burrell, TA; Taffet, SM; Vincenti, MP | 1 |
| Chiou, S; Davis, JS; Fineberg, NS; Ganguly, A | 1 |
| Barrett, KE; Dharmsathaphorn, K; Dinh, S; Kachintorn, U; Vajanaphanich, M; Vongkovit, P | 1 |
| Belosevic, M; Daniels, CW | 1 |
| Gross, JL; Mochan, E; Newton, RC; Rommi, W; Uhl, J | 1 |
| Dell'Era, P; Presta, M; Ragnotti, G; Rusnati, M; Tiberio, L | 1 |
| Bernstein, SH; Kharbanda, SM; Kufe, DW; Sherman, ML; Stone, RM | 1 |
| Borden, EC; Brown, RR; Ozaki, Y; Smalley, RV | 1 |
| Decker, K; Schulze-Specking, A; Weinhold, L | 1 |
| Casillas, T; Delicado, EG; Miras-Portugal, MT; Sen, RP | 1 |
| Althaus, HH; Klöppner, S; Neuhoff, V; Rohmann, A; Schröter, J; Schwartz, P; Spoerri, P | 1 |
| Barreau, P; Basset, M; Cost, H; Geny, B; Le Peuch, C | 1 |
| Ginsberg, J; Murray, PG | 1 |
| Caron, L; Grose, JH; Landry, J; Lebel, M | 1 |
| Arita, H; Hanasaki, K; Kishi, M | 2 |
| Caldwell, CW; Patterson, WP; Yesus, YW | 1 |
| Arduino, C; Avanzi, GC; Brizzi, MF; Bussolino, F; Pegoraro, L | 1 |
| Ashcroft, SJ; Niki, I | 1 |
| Celada, A; Maki, RA | 1 |
| Chan, YL; Wang, T | 1 |
| Ishikawa, S; Saito, T | 1 |
| Kim, KM; Mayumi, M; Mikawa, H; Nambu, M; Tanaka, M; Watanabe, H | 1 |
| Endou, M; Hattori, Y; Kanno, M; Tohse, N | 1 |
| Sancho-Tello, M; Terranova, PF | 1 |
| Banks, P; Monk, PN | 1 |
| Doré, M; Neilsen, NR; Slauson, DO | 1 |
| Raymond, JR | 1 |
| Hallahan, DE; Huberman, E; Kufe, DW; Sherman, ML; Virudachalam, S; Weichselbaum, RR | 1 |
| Francis, J; Pon, DJ; Qu, Y; Sen, AK; Torchia, J | 1 |
| Barluzzi, R; Bistoni, F; Blasi, E; Mazzolla, R | 1 |
| Howcroft, TK; Lindquist, RR | 1 |
| Beraud, M; Cambon, C; Didier, A; Forgue, MF; Pinelli, E; Pipy, B; Souqual, MC; Vandaele, J | 1 |
| Aragon, C; Casado, M; Gimenez, C; Gomeza, J | 1 |
| Fu, T; Nozawa, Y; Okano, Y | 1 |
| Chang, ZL; Novotney, M; Suzuki, T; Uchiyama, H | 1 |
| Deery, WJ; Rani, CS | 1 |
| Chang, JP; de Leeuw, R; Jobin, RM | 1 |
| Mattila, P; Renkonen, R | 1 |
| Harbers, M; Hilz, H | 1 |
| Coffee, KA; Cook, JA; Geisel, J; Halushka, PV; Wise, WC | 1 |
| Kageyama, H; Kikuchi, K; Kuroki, T; Nose, K; Sakiyama, S; Shibanuma, M | 1 |
| Ghoneum, M; Gollapudi, S; Suzuki, K | 1 |
| Ganguly, NK; Khullar, M; Khurana, S; Panigrahi, D; Walia, BN | 1 |
| Campbell, AK; Rapoport, RM | 1 |
| Davidson, MB; Furman, A; Molnar, IG; Yamaguchi, D | 1 |
| Tai, HH; Tian, ZG; Xun, CQ | 1 |
| Anwer, K; Hovington, JA; Sanborn, BM | 1 |
| Matsuda, T; Noguchi, T; Takenaka, M; Tanaka, T; Yamada, K | 1 |
| Huang, CK; Laramee, GR; Sha'afi, RI; Yamazaki, M | 1 |
| Critelli, M; Lyons, MB; Norris, DA; Yohn, JJ | 1 |
| Okada, Y; Sakurai, T; Shibata, Y; Tomita, H | 1 |
| Abboud, CN; Lichtman, MA; Packman, CH; Sham, RL | 1 |
| Haystead, TA; Krebs, EG; Licciardi, KA; Meier, KE | 1 |
| Kanaho, Y; Miura, K; Nozawa, Y; Yamada, K | 1 |
| Hendey, B; Mamrack, MD | 1 |
| Harmody, D; Longley, RE | 1 |
| Mattson, MP | 1 |
| Butler, AP; Mar, PK; McDonald, FF; Ramsay, RL | 1 |
| Kennedy, AR; Su, LN; Toscano, WA | 1 |
| Martin, DB; Pek, SB; Thomas, TP | 1 |
| Brown, ML; Cohen, RA; Tesfamariam, B | 1 |
| Azhderian, EM; Kaczmarek, LK | 1 |
| Harnish, DG; Polyak, SJ; Rawls, WE | 1 |
| Hurme, M; Serkkola, E | 1 |
| Bomsztyk, K; Dower, SK; Iwasaki, T; Rachie, NA; Rooney, JW; Sibley, CH | 1 |
| Hoffman, R; Newlands, ES | 1 |
| Burch, RM; Connor, JR; Shearer, BG; Sullivan, JP; Tiffany, C | 1 |
| Foster, DA; Joseph, CK; Maroney, A; Qureshi, SA; Rim, M | 1 |
| Car, BD; Doré, M; Slauson, DO; Suyemoto, MM | 1 |
| Bement, WM; Capco, DG | 1 |
| Matsuda, M; Okabe, T; Sugimoto, N | 1 |
| Kato, Y; Tanigawa, K; Tsuchiyama, S | 1 |
| Edashige, K; Iwata, M; Saeki, K | 1 |
| Cottam, GL; Matsunaga, A; Miller, BC | 1 |
| Conquer, J; Mahadevappa, VG | 1 |
| Deuel, TF; Shawver, LK | 1 |
| Ganguly, NK; Garg, UC; Goyal, J; Walia, BN | 1 |
| Bigby, M; Fierro, JF; Sy, MS; Wang, P | 1 |
| Gimbrone, MA; Hrbolich, JK; Schafer, AI; Zavoico, GB | 1 |
| Buschie, M; Drexler, HG; Gignac, SM; Hoffbrand, AV; Pettit, GR | 1 |
| Emoto, T; Hattori, Y; Hiraiwa, M; Kasai, K; Kuroda, H; Shimoda, S; Yamazaki, A | 1 |
| Kitaoka, M; Kojima, I; Ogata, E | 1 |
| Kashimoto, T; Kondo, Y; Tachikawa, E; Takahashi, S | 1 |
| Ardaillou, R; Bens, M; Guidet, B; Lacave, R; Nagamine, Y; Rondeau, E; Sraer, J; Sraer, JD | 1 |
| Bhalla, RC; Chiang, JJ; Loeber, CP; Potts, JD; Runyan, RB; Sharma, RV | 1 |
| Russell, JA; Steffan, M | 1 |
| Ansotegui, IJ; Chow, SC; Jondal, M | 1 |
| Dean, WL; Klein, JB; McLeish, KR; Schepers, TM; Sonnenfeld, G | 1 |
| Hargrove, ME; Henrich, P; Ting, CC | 1 |
| Andersson, LC; Mustelin, T; Nordström, T; Pessa-Morikawa, T; Ståhls, A | 1 |
| Aguet, M; Ballotti, R; Mao, C; Merlin, G; Metzler, M | 1 |
| Gay, JC; Stitt, ES | 1 |
| Goldthwait, DA; Lin, CS; Samols, D | 1 |
| Kajiyama, Y; Murayama, T; Nomura, Y; Takahashi, A | 1 |
| AbuBakar, S; Albrecht, T; Boldogh, I | 1 |
| Gottlieb, RA; Jiang, WP; Kinsey, WH; Lennarz, WJ | 1 |
| el-Fakahany, EE; Lai, WS; Rogers, TB | 1 |
| Kato, Y; Ogawa, K; Okuda, T; Sawada, H; Tashima, M; Ueda, T; Yumoto, Y | 1 |
| Franke, T; Glusa, E; Markwardt, F; Nilius, B | 1 |
| Chow, SC; Jondal, M | 1 |
| Ambrus, JL; Chesky, L; Fan, XD; Goldstein, H; Koerholz, D | 1 |
| al-Bagdadi, F; Arlinghaus, RB; Singh, B | 1 |
| Ito, N; Kawata, S; Shirai, Y; Takaishi, K; Tamura, S; Tarui, S | 1 |
| Fisher, TE; Kaczmarek, LK | 1 |
| Badwey, JA; Heyworth, PG; Robinson, JM | 1 |
| Boneh, A; Mandla, S; Tenenhouse, HS | 1 |
| Chan, SO; Wong, SS; Yeung, DC | 1 |
| Hurme, M; Ronni, T; Serkkola, E; Silvennoinen, O | 1 |
| Black, CK; Cheng, HC; Dage, RC; Jones, WD; Kariya, T; Robinson, PJ; Schmidt, CJ | 1 |
| Keller, HU | 1 |
| Hishinuma, K; Hosono, A; Inaba, H; Kimura, S | 1 |
| Betts, WH; French, JK; Hurst, NP | 1 |
| Brunsing, D; Hensel, G; Krönke, M; Meichle, A; Schütze, S | 1 |
| Larsson, R; Nygren, P | 1 |
| Camps, M; Gumà, A; Palacín, M; Testar, X; Zorzano, A | 1 |
| Kato, K; Morimura, S; Tashiro, F; Ueno, Y | 1 |
| Bankey, P; Carlson, A; Cerra, F; Ortiz, M; Singh, R | 1 |
| Fujiwara, K; Hirata, K | 1 |
| Fuchimoto, S; Matsubara, N; Orita, K | 1 |
| Corsini, E; Galli, CL; Marinovich, M; Restani, P | 1 |
| Buckley, DJ; Cooper, DR; Farese, RV; Hoffman, JM; Ishizuka, T; Pollet, RJ; Standaert, ML | 1 |
| Bixby, JL; Jhabvala, P | 1 |
| Buckley, NE; Gibson, K; Spiegel, S; Zhang, H | 1 |
| Fredholm, B; Gullberg, M; Jondal, M; Kvanta, A; Nordstedt, C | 1 |
| Gustavsson, L; Hansson, E | 1 |
| Bollinger, DW; Franklin, CC; Kim, HD; Turner, JT | 1 |
| Inui, N; Semba, M | 1 |
| Sandborg, RR; Smolen, JE | 1 |
| Baglioni, C; Johnson, SE | 1 |
| David, JD; Faser, CR; Perrot, GP | 1 |
| Kalberg, CJ; Sumners, C | 1 |
| Lau, LF; Lee, CM; Xu, H | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Guitart, X; Marsal, J; Solsona, C | 1 |
| Baines, AD; Ho, P | 1 |
| Becker, D; Beebe, SJ; Herlyn, M | 1 |
| Kurtz, A; Scholz, H | 1 |
| Homonnai, ZT; Kalina, M; Naor, Z; Paz, GF; Rotem, R | 1 |
| García-Sáinz, JA; Hong, E; Ransanz, V; Torres-Márquez, ME; Villalobos-Molina, R | 1 |
| Jhaveri, S; Laurence, J; Salmon, JE; Sikder, SK | 1 |
| Nakashima, S; Nozawa, Y; Okano, Y; Takagi, H; Tohmatsu, T | 1 |
| Pandol, SJ; Schoeffield, MS | 1 |
| Conroy, MC; Kennedy, JA; Thueson, DO; Wright, CD | 1 |
| Inoue, S; Kitajima, Y; Nagao, S; Nagata, K; Nozawa, Y; Yaoita, H | 1 |
| Hashimoto, Y; Shimomura, H; Soderling, TR; Terada, A | 1 |
| Johnson, AL; Tilly, JL | 1 |
| Grosman, N; Nielsen, KA | 1 |
| Hogans, BB; Spivak, JL; Stuart, RK | 1 |
| Bomsztyk, K; Ostrowski, J | 1 |
| Hui, KK; Yu, JL | 1 |
| Clark, EA; Meier, KE; Rossie, S; Valentine, MA | 1 |
| Alonso, M; Cárdenas, L; Carrera, AC; de Landázuri, MO; Sánchez-Madrid, F; Tugores, A | 1 |
| Friedman, E; Wang, HY | 1 |
| Fuse, I; Iwanaga, T; Tai, HH | 1 |
| Needleman, P; Raz, A; Wyche, A | 1 |
| Hartzell, P; Jondal, M; McConkey, DJ; Orrenius, S | 1 |
| Levin, EG; Marotti, KR; Santell, L | 1 |
| Ishimura, Y; Kizaki, H; Muramatsu, J; Odaka, C; Tadakuma, T | 1 |
| Douglas, SD; Hassan, NF; Kamani, N; Meszaros, MM | 1 |
| Christiansen, NO; Larsen, CS | 1 |
| Kaever, V; Pfannkuche, HJ; Resch, K | 1 |
| Hamamoto, Y; Hayashida, Y; Kobayashi, N; Kobayashi, S; Tamaoki, T; Yamamoto, N | 1 |
| Halldórsson, H; Kjeld, M; Magnússon, MK; Thorgeirsson, G | 1 |
| Cianciolo, GJ; Dinarello, CA; Gottlieb, RA; Kleinerman, ES; Knowles, RD; Lachman, LB; Lennarz, WJ | 1 |
| Cosowsky, L; Raufman, JP | 1 |
| Shen, SS | 1 |
| Becker, EL; Gomez-Cambronero, J; Mege, JL; Molski, TF; Sha'afi, RI | 1 |
| Becker, EL; Durstin, M; Gomez-Cambronero, J; Molski, TF; Sha'afi, RI; Yamazaki, M | 1 |
| Bedoy, CA; Mobley, PL | 1 |
| Murayama, T; Nomura, Y; Ui, M | 1 |
| Iizuka, H; Sakai, H; Tamura, T | 1 |
| Insel, PA; Slivka, SR; Weiss, BA | 1 |
| Akerlind, G; Akerman, KE; Heikkilä, JE | 1 |
| Jacobson, D; O'Flaherty, JT | 1 |
| Maier, JA; Presta, M; Ragnotti, G | 2 |
| Beattie, LL; Cragoe, EJ; Gerrard, JM; Israels, SJ; Lint, D; McNicol, A; Park, J | 1 |
| Keller, HU; Niggli, V; Zimmermann, A | 1 |
| Gavioli, R; Giuliani, AL; Spisani, S; Traniello, S | 1 |
| Bixby, JL | 1 |
| Boner, G; Gbarah, A; Mhashilkar, AM; Sharon, N | 1 |
| Aizu, E; Kato, R; Nakadate, T; Nishikawa, K; Yamamoto, S | 1 |
| Souhrada, JF; Souhrada, M | 2 |
| Borowski, P; Harbers, M; Hilz, H; Kischel, T; Müller, K; Stabel, S | 1 |
| Maruyama, Y | 1 |
| Bartone, D; Smolen, JE; Stoehr, SJ | 1 |
| Lewis, CE; Morris, JF; Richards, PS | 1 |
| Hsu, T; Simpson, RU; Taylor, JM; Wendt, MD | 1 |
| Kaever, V; Pfannkuche, HJ; Resch, K; Wessel, K | 1 |
| Contreras-Rodríguez, JL; García-Sáinz, JA; Hernández-Sotomayor, SM; Macías-Silva, M | 1 |
| Daynes, RA; Huang, K; Im, SY; Samlowski, WE | 1 |
| Halldórsson, H; Thorgeirsson, G | 1 |
| Lamkin, GE; Lane, TA; Wancewicz, E | 1 |
| Komada, F; Nishikawa, M; Shirakawa, S; Uemura, Y | 1 |
| Kistner, O; Müller, K; Scholtissek, C | 1 |
| Sonoki, H; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| De Pont, JJ; Van den Broek, BA; Van Os, CH; Willems, PH | 1 |
| Chander, A; Dodia, C; Fisher, AB | 1 |
| Rillema, JA; Tarrant, TM; Waters, SB | 1 |
| Bouic, P; Nel, AE; Rheeder, A; Schabort, I; Wooten, MW | 1 |
| Gerard, C; McCall, C; Salzer, W | 1 |
| Kato, Y; Mochizuki, T; Okazaki, T; Sawada, H; Tashima, M; Uchino, H | 1 |
| Barile, G; Faggioni, A; Frati, L; Grimaldi, S; Lazdins, J; Venanzoni, M; Zompetta, C | 1 |
| Dougherty, RW; Niedel, JE; Rider, LG | 1 |
| Gomez-Cambronero, J; Huang, CK; Molski, TF; Sha'afi, RI | 1 |
| Della Bianca, V; Dusi, S; Grzeskowiak, M; Rossi, F | 1 |
| Schächtele, C; Seifert, R | 1 |
| Berkow, RL; Dodson, MR | 1 |
| Bollinger, DW; Toews, ML; Turner, JT | 1 |
| Hirakawa, M; Okimasu, E; Tsuchiya, M; Ueda, W; Utsumi, K | 1 |
| Büscher, M; Herrlich, P; Karin, M; Litfin, M; Rahmsdorf, HJ | 1 |
| Fujita, T; Fukase, M; Hishikawa, R; Kinoshita, Y | 1 |
| Ida, E; Onoue, K; Sakata, A; Tominaga, M; Yamasaki, H | 1 |
| Dan'ura, T; Higashi, K; Ishibashi, S; Kurokawa, T; Yamashita, A | 1 |
| Jaiswal, N; Jaiswal, RK; Sharma, RK | 1 |
| Jaiswal, RK; Sharma, RK | 1 |
| Adamo, S; Cavallo, G; Frati, L; Gismondi, A; Paolini, R; Piccoli, M; Procopio, AD; Santoni, A | 1 |
| Conn, PJ; Kaczmarek, LK; Strong, JA | 1 |
| Bhat, NR | 1 |
| Bass, DA; Gerard, C; Marfat, A; McCall, CE; McPhail, LC; Stimler-Gerard, NP | 1 |
| Hattori, H; Nagao, S; Nozawa, Y; Ohki, K; Tohmatsu, T | 1 |
| Huang, CK; Molski, TF; Naccache, PH; Sha'afi, RI | 1 |
| Ford, C; Molski, TF; Sha'afi, RI; Weisman, SJ | 1 |
| Endo, T; Haraguchi, K; Onaya, T | 1 |
| Maridonneau-Parini, I; Tauber, AI; Tringale, SM | 1 |
| Hidaka, H; Kawakami, K; Ohmura, T; Onoue, K; Yamamoto, Y | 1 |
| Fujita, I; Minakami, S; Takeshige, K | 1 |
| Maxeiner, B; Pfizenmaier, K; Scheurich, P; Thoma, B; Unglaub, R; Zugmaier, G | 1 |
| Hoffman, MD; Wright, CD | 1 |
| Berkow, RL; Dodson, RW; Kraft, AS | 1 |
| el-Fakahany, EE; Lai, WS | 1 |
| Ida, E; Onoue, K; Sakata, A; Tominaga, M | 1 |
| Bazan, HE; Dobard, P; Reddy, ST | 1 |
| Berlin, RD; Pearson, CM; Preston, SF; Volpi, M | 1 |
| Amiel, C; Friedlander, G | 1 |
| Dean, WL; McLeish, KR; Wellhausen, SR | 1 |
| Ina, Y; Koide, Y; Nezu, N; Yoshida, TO | 1 |
| Bhat, NK; Diaz de la Espina, SM; Fisher, RJ; Fujiwara, S; Papas, TS | 1 |
| Ikebuchi, H; Suzuki, K; Terao, T; Teshima, R | 1 |
| Fujita, T; Katakami, N; Katakami, Y; Koizumi, T; Matsui, T; Nakao, Y | 1 |
| Daniel, LW; Parker, J; Waite, M | 1 |
| Houchi, H; Misbahuddin, M; Morita, K; Nakanishi, A; Oka, M | 1 |
| Leung, PC; Wang, J | 1 |
| Nachmias, VT; Yoshida, K | 1 |
| Halenda, SP; Rehm, AG | 1 |
| Matsumoto, T; Sha'afi, RI; Tao, W | 1 |
| Bloom, BR; Fan, XD; Goldberg, M | 1 |
| Gershengorn, MC; Winicov, I | 1 |
| Hoek, JB; Rubin, R; Thomas, AP | 1 |
| Bomsztyk, K; Meier, KE; Ostrowski, J; Smith, LL; Stanton, TH | 1 |
| Fuse, I; Tai, HH | 1 |
| Christensen, SB; Fujiki, H; Hirasawa, N; Ohuchi, K; Sugawara, T; Sugimura, T; Tsurufuji, S; Watanabe, M | 1 |
| Hogans, BB; Spivak, JL | 1 |
| Gemmell, MA; Homma, Y; Huberman, E | 1 |
| Craven, PA; DeRubertis, FR; Patterson, MC | 1 |
| Akerman, KE; Heikkilä, JE; Jalava, AM | 1 |
| Mitsuhashi, M; Payan, DG | 1 |
| Chatila, TA; Geha, RS | 1 |
| Brahmi, Z; Steele, TA | 1 |
| Caramelo, C; Schrier, RW; Tsai, P | 1 |
| Gollapudi, S; Gupta, S; Vayuvegula, B | 1 |
| Kagnoff, MF; Kelleher, D; Pandol, SJ | 1 |
| Cragoe, EJ; Dexter, TM; Heyworth, CM; Monk, PN; Vallance, SJ; Whetton, AD | 1 |
| Koide, T; Niki, A; Niki, H; Niki, I; Sakamoto, N; Tamagawa, T | 1 |
| Blackshear, PJ; Chu, DT; Granner, DK; Stumpo, DJ | 1 |
| Akerström, G; Gylfe, E; Johansson, H; Juhlin, C; Klareskoq, L; Larsson, R; Nygren, P; Rastad, J | 1 |
| Khalil, RA; van Breemen, C | 1 |
| García-Sáinz, JA; Hernández-Sotomayor, SM | 1 |
| Deli, E; Kiss, Z; Kuo, JF | 1 |
| Hidaka, H; Nishikawa, M; Shirakawa, S; Uemura, Y | 1 |
| Baba, H; Fujimi, T; Fujita, T; Fukase, M; Kinoshita, Y; Yamaguchi, T | 1 |
| Bass, DA; Gerard, C; McCall, CE; McPhail, LC; Olbrantz, P; Wilson, J | 1 |
| Craven, PA; DeRubertis, FR | 1 |
| Harbeck, RJ; Struhar, D | 1 |
| Carroll, AG; Eckberg, WR; Szuts, EZ | 1 |
| Aizu, E; Kato, R; Kiyoto, I; Yamamoto, S | 1 |
| Blusztajn, JK; Liscovitch, M; Slack, B; Wurtman, RJ | 1 |
| Ishibashi, S; Ohtsuka, T; Okamura, N | 1 |
| Asao, T; Hidaka, H; Ido, M; Inagaki, M; Saito, M; Sakurai, M | 1 |
| Ishii, K; Kato, R; Sasakawa, N; Yamamoto, S | 1 |
| Hidaka, H; Inagaki, M; Kawamoto, S | 1 |
| Hidaka, H; Kawamoto, S | 1 |
| Eling, TE; Hamasaki, Y | 1 |
| Cole, OF; Elder, MG; Seki, H; Sullivan, MH | 1 |
| Hidaka, H; Isobe, K; Nakashima, I; Ohkusu, K | 1 |
| Betz, H; Sato, K; Schloss, P | 1 |
| Cheung, HS; Mitchell, PG | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| Pratt, MM; Salathe, M; Wanner, A | 1 |
| de Prost, D; Hakim, J; Khechai, F; Ollivier, V; Ramani, M; Ternisien, C; Vu, T | 1 |
| Iitaka, M; Ishii, J; Kitahama, S | 1 |
| Endo, T; Kumegawa, M; Takahashi, Y; Taketani, Y; Yamamoto, S | 1 |
| Keen, M; Krane, A; Malkhandi, J; Mercy, L | 1 |
| Campenot, RB; Draker, DD; Senger, DL | 1 |
| Allen, JM; Balbi, D | 1 |
| Hügel, U; Klaus, G; May, T; Mayer, H; Mehls, O; Ritz, E; von Eichel, B | 1 |
| Heike, T; Jung, EY; Katamura, K; Mayumi, M; Ohshima, Y; Shintaku, N; Sumimoto, S | 1 |
| Walters, JD; Wojcik, MS | 1 |
| Di Virgilio, F; Foresta, C; Rossato, M | 1 |
| Homma, I; Inazu, M; Sakai, Y; Shamoto, A; Zhu, B | 1 |
| Chik, CL; Ho, AK; Inukai, T | 1 |
| Alpern, RJ; Amemiya, M; Cano, A; Miller, RT; Moe, OW; Preisig, PA; Yamaji, Y | 1 |
| Irimura, T; Kakiuchi, T; Koike, C; Okada, S; Oku, N; Tsukada, H; Watanabe, M | 1 |
| Azuma, Y; Ishimura, Y; Kizaki, H; Onishi, Y; Suzuki, K | 1 |
| Ijichi, A; Sakuma, S; Tofilon, PJ | 1 |
| Danielsen, M; Garcia-Morales, P; Katz, D; Martin, MB; Pierce, M; Saceda, M; Solomon, HB; Stoica, A; Zhang, S | 1 |
| Moffat, MP; Ward, CA | 1 |
| Kozawa, O; Oiso, Y; Shinoda, J; Suzuki, A | 1 |
| Badwey, JA; Curnutte, JT; Ding, J; Erickson, RW; Heyworth, PG | 1 |
| Goishi, K; Higashiyama, S; Ishikawa, M; Klagsbrun, M; Mekada, E; Nakano, N; Taniguchi, N; Umata, T | 1 |
| Ren, Y; Smith, A | 1 |
| Brunner, F | 1 |
| Abel, K; Azad, N; Emanuele, NV; La Paglia, N; Mohagheghpour, N | 1 |
| Boscherini, B; Del Principe, D; Germani, D; Sesti, G; Spadoni, GL; Spagnoli, A | 1 |
| Aarnoudse, C; Nibbering, PH; van Furth, R; Zheng, L; Zomerdijk, TP | 1 |
| DiBattista, JA; Iwata, K; Martel-Pelletier, J; Pelletier, JP; Zafarullah, M | 1 |
| Chao, CC; Hu, S; Peterson, PK | 1 |
| Arola, J; Heikkilä, P; Kahri, AI; Salmi, A | 1 |
| Reich, H; Sei, Y | 1 |
| Abboud, SL | 1 |
| Brum, RL; Calixto, JB; Silva, AM | 1 |
| Chorvath, B; Duraj, J; Koppel, J; Kovacikova, M; Sedlak, J; Sobel, A | 1 |
| Akard, L; Cui, Y; English, D; Garcia, JG; Harvey, K; Jansen, J; Martin, MI; Siddiqui, RA; Thompson, J; Wentland, J | 1 |
| Dickson, RB; Johnson, GR; Martínez-Lacaci, I; Normanno, N; Plowman, GD; Saceda, M; Salomon, DS | 1 |
| Chen, SL; Huang, CH; Lin, YK; Tsao, YP | 1 |
| Kloner, RA; Przyklenk, K; Simkhovich, BZ; Sussman, MA | 1 |
| Atkins, KB; Troen, BR | 1 |
| Abayasekara, RE; Flint, AP; Searle, MJ | 1 |
| Bischer, P; Cantu, AR; Pavone, A; Reiners, JJ; Schöller, A | 1 |
| Daniel, EE; Kwan, CY; Shimamoto, H; Shimamoto, Y | 1 |
| Niedbala, MJ; Stein-Picarella, M | 1 |
| Abraham, RT; Lutz, MP; Miller, LJ; Sutor, SL | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Chorváth, B; Hunáková, L; Sedlák, J | 1 |
| Audesirk, G; Cabell, L | 1 |
| Fujimoto, T; McEver, RP | 1 |
| Evans, SW; Thompson, D; Whicher, JT | 1 |
| Nishida, A; Shimizu, M; Yamawaki, S | 1 |
| Broxmeyer, HE; Horie, M; Yip-Schneider, MT | 1 |
| Hirano, F; Inaba, M; Makino, I; Makino, Y; Miura, T; Okamoto, K; Tanaka, H | 1 |
| Okatani, Y; Sagara, Y; Taniguchi, K | 1 |
| Ganguly, NK; Kanwar, RK; Kumar, L; Panigrahi, D; Rakesh, J; Walia, BN | 1 |
| Baghdiguian, S; Delézay, O; Fantini, J | 1 |
| Hauser, C; Jongeneel, CV; Lisby, S; Müller, KM; Saurat, JH | 1 |
| Falk, LA; Halder, S; Mufson, RA; Rinaudo, MS; Su, K | 1 |
| Brown, BL; Dobson, PR; Virdee, K | 1 |
| Arthur, JM; Hartle, JE; Middleton, JP; Quarles, LD; Raymond, JR; Zhang, J | 1 |
| Chen, H; Jassar, BS; Kurenny, DE; Smith, PA | 1 |
| Arai, S; Chowdhury, MI; Koyanagi, Y; Munakata, T; Yamamoto, N | 1 |
| Fujita, S; Horiuchi, T; Watanabe, I | 1 |
| Baloch, Z; Coffman, FD; Cohen, S; Fresa, K | 1 |
| Kamata, M; Kim, J | 1 |
| Kawase, Y; Min, KR; Mue, S; Ohuchi, K; Tanabe, J; Watanabe, M | 1 |
| Grebenkämper, K; Nicolau, C | 1 |
| Dixon, SJ; Gallinaro, BJ; Reimer, WJ | 1 |
| Collado-Escobar, D; Mollinedo, F; Pérez-Sala, D | 1 |
| Zhang, L | 1 |
| Gerdes, W; Louis, JC; Magal, E; Seifert, W | 1 |
| Fusamoto, H; Hayashi, N; Horimoto, M; Ito, T; Kamada, T; Kaneko, A; Kasahara, A; Sasaki, Y; Tanaka, Y | 1 |
| Leeb-Lundberg, LM; Mathis, SA; Song, XH | 1 |
| Cheng, H; Lakatta, EG; Lederer, WJ; Suzuki, T; Xiao, RP | 1 |
| Bouzinba-Segard, H; Castagna, M; Fan, XT; Perderiset, M | 1 |
| Gardner, JD; Huang, SC; Pandya, PK; Talkad, VD; Wank, SA | 1 |
| Csaba, G; Hegyesi, H | 1 |
| Benítez-King, G; Carbajal, ME; Meza, I; Santiago, A | 1 |
| Almazan, G; Radhakrishna, M | 1 |
| Atwood, WJ; Conant, K; Major, EO; Tornatore, C; Traub, R | 1 |
| Isselbacher, KJ; Ohta, T; Rhoads, DB; Shioda, T | 1 |
| Rembish, SJ; Trush, MA; Yang, Y | 1 |
| Itoh, M; Joh, T; Kato, T; Miyamoto, T; Okayama, N | 1 |
| Crockett, J; Levine, RA; Nandi, J | 1 |
| Emerling, D; Hashimoto, Y; Horie, Y; Kinoshita, M; Kurokawa, K; Nakao, A; Tsukamoto, K; Watanabe, T | 1 |
| Butler, AP; Fischer, SM; Lee, WY; Locniskar, MF | 1 |
| Amano, S; Hanazawa, S; Kawata, Y; Kitano, S; Miyata, Y; Nakada, Y | 1 |
| Dobrovinskaya, OR; Eidus, LKh; Korystov, YN; Shaposhnikova, VV | 1 |
| Fujii, N; Matsumoto, A; Nomizu, M; Okusu, A; Otaka, A; Tamamura, H; Weeks, BS; Weston, CA; Yamamoto, N | 1 |
| Arola, J; Heikkilä, P; Kahri, AI; Voutilainen, R | 1 |
| Larivée, P; Levine, SJ; Logun, C; Martinez, A; Shelhamer, JH; Wu, T | 1 |
| Achenbach, F; Blum, S; Ness, W; Petrow, W | 1 |
| el Benna, J; Hakim, J; Labro, MT | 1 |
| Inaba, M; Koyama, H; Morii, H; Nishizawa, Y; Ohno, S | 1 |
| Hidaka, H; Iwamoto, T; Nakashima, I; Ohkusu, K; Watanabe, M | 1 |
| Audette, M; Bouillon, M | 1 |
| Andersen, CB; Hansen, AB | 1 |
| Hasegawa, T | 1 |
| Daniels, S; Duncan, CJ | 1 |
| Akagi, Y; Ito, K; Sawada, S | 1 |
| Andersen, CB; Bouchelouche, PN; Giese, BN; Hansen, AB | 1 |
| Chihara, K; Fukase, M; Kano, J; Sugimoto, T; Yamaguchi, T | 1 |
| Chapes, SK; Woods, KM | 1 |
| Chaki, S; Muramatsu, M; Otomo, S | 1 |
| Boland, R; de Boland, AR; Morelli, S | 1 |
| ffrench-Mullen, JM; Plata-Salamán, CR | 1 |
| Terranova, PF; Zachow, RJ | 1 |
| Dautrevaux, M; Formstecher, P; Lefebvre, P; Tahayato, A | 1 |
| Auger, EA; Chen, EY; Giaccia, AJ; Koong, AC | 1 |
| Arao, M; Chihara, K; Fukase, M; Sugimoto, T; Yamaguchi, T | 1 |
| Edashige, K; Kawada, M; Utsumi, K; Watanabe, Y; Yasuda, T | 1 |
| Dahmer, MK; Penberthy, WT | 1 |
| Golinski, P; Neusser, M; Rahn, KH; Spieker, C; Tepel, M; Zhu, Z; Zidek, W | 1 |
| Kahri, A; Liu, J; Teppo, AM; Voutilainen, R | 1 |
| Kordon, C; L'Héritier, A; Leblanc, P; Rasolonjanahary, R | 1 |
| Kubota, C; Murata, Y; Shinagawa, T; Shinohara, O | 1 |
| Chang, JP; Neumann, CM; Van Goor, F | 1 |
| Hertelendy, F; Jamaluddin, M; Marrone, BL; Molnár, M | 1 |
| Kume, S; Ozaki, Y; Satoh, K; Yatomi, Y | 1 |
| Argenzio, RA; Berschneider, HM; Chen, W; Chu, P; Paradiso, AM; Rhoads, JM | 1 |
| Ishihara, H; Nagaki, M; Sasaki, H; Shimura, S; Takishima, T | 1 |
| Combadière, C; el Benna, J; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Larsen, TH; Lillehaug, JR; Myking, O; Saetersdal, T | 1 |
| Sontheimer, H; Thio, CL | 1 |
| Gali, RR; Khandelwal, RL; Pugazhenthi, S | 1 |
| Arai, M; Nozawa, R; Sasaki, Y | 1 |
| Marquardt, H; Schmutte, C; Wölfle, D | 1 |
| Fox, WM; Korach, KS; Migliaccio, S; Washburn, TF; Wetsel, WC | 1 |
| Haberstock, H; Marotti, T | 1 |
| Ahn, NG; Narayanan, AS; Raines, EW; Yonemura, K | 1 |
| Hosono, T; Ito, A; Mori, Y; Nagase, H; Ojima, Y; Sato, T; Takahashi, S | 1 |
| Hara, A; Taketomi, T; Uemura, K | 1 |
| Benistant, C; Gustavsson, L; Hoek, JB; Moehren, G; Rubin, R; Torres-Marquez, ME | 1 |
| Hakomori, S; Igarashi, Y; Mazurek, N; Megidish, T | 1 |
| Colucci, WS; Izzo, NJ; Tulenko, TN | 1 |
| Mitchell, MD; Pollard, JK | 1 |
| Dana, R; Leto, TL; Levy, R; Malech, HL | 1 |
| Goto, M; Goto, MP; Hurley, RM; Picken, M; Zeller, WP | 1 |
| Fukushima, D; Ishiura, S; Konishi, M; Maruyama, K; Miyamoto, T; Suzuki, K | 1 |
| Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH | 1 |
| Cunningham, GR; House, FS; Stewart, SJ | 1 |
| Hu, ZL; Qian, DH | 1 |
| Arizono, K; Brady, FO; Peterson, KL | 1 |
| Collins, JL; Manning, K; Powell, CB | 1 |
| Hinko, A; Soloff, MS | 1 |
| Iizuka, H; Takahashi, H | 1 |
| Aste, M; Calzetti, F; Cassatella, MA; Ceska, M; Constantin, G; Guasparri, I; Rossi, F | 1 |
| Lewis, CE; McGee, JO; Pusztai, L | 1 |
| Hidaka, H; Iguchi, A; Niki, A; Niki, H; Niki, I; Okazaki, K; Saitoh, M; Tamagawa, T | 1 |
| Larsson, C; Simonsson, P | 1 |
| Fujihara, M; Ito, N; Muroi, M; Muroi, Y; Suzuki, T | 1 |
| Muroi, M; Suzuki, T | 1 |
| Ayuso, MS; Butta, N; Ciprés, G; Manchón, CG; Parrilla, R; Requero, AM; Urcelay, E | 1 |
| Nakano, R; Shimamoto, T; Yamoto, M | 1 |
| Dunlop, M; Keogh, R; Larkins, RG | 1 |
| Baldari, CT; Heguy, A; Telford, JL | 1 |
| Kharbanda, S; Kufe, D; Nakamura, T | 1 |
| Bertrand, N; McCarron, R; Spatz, M; Stanimirovic, DB | 1 |
| Crow, T; Forrester, J | 1 |
| Gobran, LI; Griese, M; Rooney, SA | 1 |
| Ginsberg, J; Matowe, W; Murray, PG | 1 |
| Dziak, E; Opas, M; Zhou, Y | 1 |
| Abboud, HE; Bhandari, B | 1 |
| Harada, H; Motomura, A; Suketa, Y; Suzuki, S; Tai, H | 1 |
| Kitamura, Y; Miyazaki, A; Nomura, Y | 1 |
| Heimerl, P; Hofer, HW; Stader, C; Willmann, R | 1 |
| Geberhiwot, T; Skoglund, G | 1 |
| Dussault, JH; Etongue-Mayer, P; Puymirat, J | 1 |
| Amino, K; Fujimoto, T; Honda, Y; Takahashi, M | 1 |
| Bollag, WB; Harmon, CS; Nevins, TD | 1 |
| Hashimoto, Y; Iizuka, H; Ishida-Yamamoto, A; Takahashi, H | 1 |
| Bosche, MC; Levine, RA; Nandi, J; Rotker, JD; Strapko, A | 1 |
| Carreras, LO; Habib, A; Lévy-Toledano, S; Maclouf, J; Martinuzzo, ME | 1 |
| Ishizuka, T; Itaya, S; Kajita, K; Nagashima, T; Nozawa, Y; Wada, H; Yamada, K; Yamamoto, M; Yasuda, K | 1 |
| Goracci, G; Gresele, P; Iorio, P; Nenci, GG; Nucciarelli, F; Stasi, M; Vezza, R | 1 |
| Buczyłko, J; Ohguro, H; Palczewski, K; Rudnicka-Nawrot, M; Taylor, JA; Walsh, KA; Zhao, X | 1 |
| Hakomori, S; Igarashi, Y; Sakakura, C; Shirahama, T; Sweeney, EA | 1 |
| Benz, D; Möller, K; Perrin, D; Söling, HD | 1 |
| Fuhrer, DK; Hamilton, J; Steussy, CN; Yang, L; Yang, YC | 1 |
| Chalfant, ML; Civan, JM; Civan, MM; DiBona, DR; O'Brien, TG; Peterson-Yantorno, K | 1 |
| Marquardt, H; Wölfle, D | 1 |
| Vernon, RG | 1 |
| Chandok, MR; Sopory, SK | 2 |
| Cohen, S; Li, W; Liu, X; Yanoff, M; Ye, X | 1 |
| McCullough, LA; Westfall, TC | 1 |
| Chander, A; Spitzer, A; Wadsworth, S; Wu, AM | 1 |
| Asai, T; McDonald, TF; Pelzer, DJ; Shuba, LM | 1 |
| Frindt, G; Palmer, LG; Windhager, EE | 1 |
| Tseng, YZ; Wang, SM; Wu, JC | 1 |
| Fujimoto, J; Ichigo, S; Ilori, M; Morishita, S; Tamaya, T | 1 |
| Galkina, SI; Margolis, LB; Sud'ina, GF | 1 |
| Carpentier, G; Lagord, C; Leibovitch, MP; Leibovitch, SA; Martelly, I | 1 |
| Fukao, H; Matsumoto, H; Matsuo, O; Mitsui, Y; Ueshima, S | 1 |
| Byers, DM; Cook, HW; Mandla, SG; Ridgway, ND | 1 |
| Denger, S; Jahn, L; Kreuzer, J; Merten, M; Schmidts, A; von Hodenberg, E | 1 |
| Bosche, MC; Levine, RA; Nandi, J | 1 |
| Bever, CT; Li, Q | 1 |
| Cabedo, H; Felipo, V; Grisolía, S; Miñana, MD | 1 |
| Yamada, Y; Yokota, M | 1 |
| Hori, M; Ikuhara, T; Isogai, Y; Matsuzaki, K; Nakamura, I; Suda, T; Suzuki, H; Takahashi, N | 1 |
| Hamada, M; Kannan, Y; Kimura, K; Moriyama, M; Musashi, M; Sakurada, K; Shiota, M; Sugano, T | 1 |
| Ha, TS; Kim, YH; Song, DK; Suh, HW; Wie, MB | 1 |
| Petersen, MM; Steadman, R; Williams, JD | 1 |
| Hashimoto, Y; Higashihara, M; Kurokawa, K; Satoh, H; Sunaga, S; Togo, M; Watanabe, T | 1 |
| Blanchette, F; Cironi, L; Maghni, K; Pouliot, N; Rola-Pleszczynski, M; Sirois, P; Stankova, J | 1 |
| Hayakawa, T; Minamino, H; Moriyama, T; Tokumura, A; Tsukatani, H | 1 |
| Berke, G; Kaplan, MR; Trubniykov, E | 1 |
| Aruffo, A; Miki, H; Nonoyama, S; Ochs, HD; Takenawa, T; Zhu, Q | 1 |
| Hall, N; Kelleher, D; Liskamp, RM; Long, A; O'Connell, MA; O'Neill, LA | 1 |
| Dobson, JG; Ethier, MF | 1 |
| Fritsche, U; Haslinger, A; Landgraf, R; Mueller, HK | 1 |
| Doherty, K; Paul, A; Plevin, R | 1 |
| Aguirre Ghiso, JA; Alonso, DF; Bal de Kier Joffé, E; Farías, EF | 1 |
| Casey, ML; Devora, GA; MacDonald, PC; Mibe, M; Morimoto, T | 1 |
| Aiuchi, T; Masuda, Y; Nakajo, S; Nakaya, K; Ohizumi, H; Watabe, M; Yoda, M | 1 |
| Aboud, M; Flügel, RM; Galron, D; Löchelt, M; Mor-Vaknin, N; Torgeman, A | 1 |
| Sjöholm, A | 1 |
| Fu, WM; Lee, KF; Tang, YB | 1 |
| Higashiyama, S; Ito, N; Kawata, S; Kiso, S; Matsuzawa, Y; Nakagawa, T; Tamura, S; Taniguchi, N; Tsushima, H | 1 |
| Shimizu, T | 1 |
| Ganguly, NK; Kaur, T; Singh, S; Verma, M | 1 |
| Arata, J; Fujimoto, W; Nakanishi, G | 1 |
| Paradiso, AM | 1 |
| Jakowlew, SB; Mariano, JM; You, L | 1 |
| Corver, WE; Dubbelman, TM; Lagerberg, JW; Rasch, MH; Tijssen, K; VanSteveninck, J | 1 |
| Edamatsu, T; Mue, S; Ohuchi, K; Tanabe, J; Xiao, YQ | 1 |
| Bellingham, J; Clair, L; LeMieur, T; Rodriguez, JL; West, MA | 1 |
| Legrand-Poels, S; Piette, J; Piret, B; Schoonbroodt, S; Zecchinon, L | 1 |
| Chapman, BM; Soares, MJ; Yamamoto, T | 1 |
| Ito, H; Spurzem, JR; Veys, TJ; Wyatt, TA | 1 |
| Kameda, T; Kishi, H; Minegishi, T; Miyamoto, K; Tano, M | 1 |
| DeLeon-Fernandez, M; Dutcher, JP; Etkind, P; Oleksowicz, L | 1 |
| Almazan, G; Larocca, JN | 1 |
| Miller, DS | 1 |
| Chan, JS; Wang, TT; Wu, XH; Zhang, SL | 1 |
| Chorváth, B; Duraj, J; Rauko, P; Sedlák, J | 1 |
| Adler, VV; Chernov, MV; Ramana, CV; Stark, GR | 1 |
| Evans, DL; Jaso-Friedmann, L; Leary, JH | 1 |
| Ayajiki, K; Okamura, T; Toda, N | 1 |
| Hasebe, A; Sasaki, T; Shibata, K; Watanabe, T | 1 |
| Dhawan, V; Ganguly, NK; Kaur, T; Singh, S | 1 |
| Dekio, S; Kishimoto, T; Tada, M; Ueda, D | 1 |
| Ezawa, H; Harigaya, K; Ishii, G; Mikata, A; Nakajima, N | 1 |
| Allert, N; Köller, H; Oel, D; Siebler, M; Stoll, G | 1 |
| Ganguly, NK; Gorowara, S; Sapru, S | 1 |
| Chow, SC; Jondal, M; Osorio, LM; Rottenberg, M | 1 |
| Kodama, H; Kurashige, T; Masuoka, N; Ohta, J; Sagara, Y; Shimazaki, Y; Ubuka, T; Wakiguchi, H; Zhang, J | 1 |
| Büscher, R; Grübbel, B; Insel, PA; Michel, MC; Taguchi, K; Yang, M | 1 |
| Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H | 1 |
| Barnum, SR; Carlino, JA; Drouin, SM; Kiley, SC | 1 |
| Aguirre Ghiso, JA; Bal de Kier Joffé, E; Ladeda, V | 1 |
| Fischer, T; Mohaupt, MG; Schulze-Lohoff, E; Schwöbel, J; Sterzel, RB | 1 |
| Hori, H; Minaguchi, H; Uemura, T | 1 |
| DiBattista, JA; Li, WQ; Su, S; Sun, Y; Zafarullah, M | 1 |
| Liu, L | 1 |
| Mufson, RA; Shi, Y; Wang, R; Yin, D; Zhang, L | 1 |
| Festoff, BW; Hantaï, D; Pindon, A | 1 |
| Ciereszko, RE; Guan, Z; Ottobre, AC; Ottobre, JS; Petroff, BK; Stokes, BT | 1 |
| Fujioka, A; Nagano, M; Nakahama, K; Sasaki, H; Shinoda, K | 1 |
| Kodama, H; Sagara, Y; Spirito, A; Sugahara, K; Zhang, J; Zhang, M | 1 |
| Liu, X; Pang, Y; Su, J; Tang, C; Wang, S; Wu, X | 1 |
| Cheung, HS; Kurup, IV; Ryan, LM | 1 |
| Abe, N; Habu, S; Iwakabe, K; Kitamura, H; Matsuki, N; Nakui, M; Nishimura, T; Ohmi, Y; Ohta, A; Sato, M; Yagita, H; Yahata, C; Yahata, T | 1 |
| Kim, SW; Levine, RA; Loo, A; Nandi, J | 1 |
| Chow, DA; Wang, H | 1 |
| Hayakawa, A; Nakashima, I; Okamoto, T; Tajiri, H; Yokoyama, I | 1 |
| Fujimoto, S; Hayakawa, T; Kawakami, N; Okamura, N; Shimohama, S; Takemasa, H | 1 |
| Akamatsu, N; Higaki, T; Imamura, H; Komatsu, S; Kono, Y; Nakagawa, M; Sato, T; Sawada, S; Tada, Y; Tamagaki, T; Toratani, A; Tsuda, Y; Tsuji, H; Yamasaki, S | 1 |
| Dietz, R; Haller, H; Li, PF; Maasch, C; von Harsdorf, R | 1 |
| Hochegger, K; Marian, B; Partik, G; Schörkhuber, M | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Hasebe, T; Nagaoka, I; Nunoi, H; Someya, A | 1 |
| Alam, T; Hamawy, MM; Knechtle, SJ; Manthei, ER; Tsuchida, M | 1 |
| Bechrakis, NE; Nass, JU; Nuskovski, M; Strauss, O; Stumpff, F; Thieme, H; Wiederholt, M | 1 |
| Cafferata, EG; Giordano, L; González-Guerrico, AM; Pivetta, OH; Santa-Coloma, TA | 1 |
| Kim, JY; Lee, SH; Moon, CH; Woo, HG | 1 |
| Abita, JP; Barbu, V; Chedeville, A; Gespach, C; Zimber, A | 1 |
| Chu, ZY; Rui, YC | 1 |
| Blandizzi, C; Colucci, R; Del Tacca, M; Tognetti, M | 1 |
| Aggarwal, BB; Manna, SK | 1 |
| Fukao, H; Matsuo, O | 1 |
| Aikawa, R; Hayashi, D; Komuro, I; Kudoh, S; Mizukami, M; Nagai, R; Shibasaki, F; Shiojima, I; Toko, H; Yazaki, Y; Zhu, W; Zou, Y | 1 |
| Arima, K; Fujisawa, K; Miyakawa, I; Narahara, H; Nasu, K; Sugano, T | 1 |
| Fukushima, A; Hashida, M; Kodama, H; Ueno, H; Zhang, J | 1 |
| Chaudhuri, S; Raha, S | 1 |
| Oleskevich, S; Walmsley, B | 1 |
| Ikewaki, N; Inoko, H; Inoue, H; Mori, N; Tamauchi, H; Yamada, A; Yamao, H | 1 |
| Bellingham, J; Clair, L; Rodriguez, JL; Wahlstrom, K; West, MA | 1 |
| Kubo, Y; Miyashita, T | 1 |
| Fujimoto, S; Hayakawa, T; Kawakami, N; Kita, K; Yamaguchi, T | 1 |
| Bando, T; Kusaka, J; Sato, M; Yamamoto, S; Yoshida, H; Yura, Y | 1 |
| Henne, J; Jeserich, G; Panofen, F; Rabe, H | 1 |
| Barratt, ME; Blades, TJ; Forsey, RJ; Hu, HL; Parmar, P; Powell, JR | 1 |
| Hong, KJ; Kang, JH; Kim, SA; Um, SJ | 1 |
| Boland, R; Buitrago, C; de Boland, AR; Morelli, S | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Gemba, M; Kohda, Y | 1 |
| Beauchemin, N; Fournès, B; Létourneau, S; Sadekova, S; Turbide, C | 1 |
| Beales, IL; Calam, J | 1 |
| Cohan, CS; Zhou , FQ | 1 |
| Abe, K; Higashi, N; Hirai, M; Hirano, T; Miki, T; Mizuno, K; Nakajima, K; Sekimoto, T | 1 |
| Bean, LJ; Chernov, MV; Lerner, N; Stark, GR | 1 |
| Bilski, JJ; Grazul-Bilska, AT; Redmer, DA; Reynolds, LP | 1 |
| Han, J; Li, Z; Wen, Z | 1 |
| Karube-Harada, A; Kashida, S; Kato, H; Nakamura, Y; Sugino, N; Takayama, H; Takiguchi, S; Yamagata, Y | 1 |
| Balaraman, S; Kapoor, P; Madhubala, R; Raj, VS; Saxena, S | 1 |
| Habibi, HR; Pati, D | 1 |
| Bui, M; Myers, JE; Whittaker, GR | 1 |
| Ichikawa, A; Mikura, S; Satoh, N; Takasu, Y; Tanaka, S | 1 |
| Chung, KH; Gye, MH; Shin, HJ; Yoo, BS | 1 |
| Balabanova, L; Fedinec, AL; Leffler, CW; Parfenova, H; Sullivan, CD; Wang, X | 1 |
| Lan, C; Vollrath, B; Wickman, G | 1 |
| Carlson, RR; Dudman, JT; Konradi, C; Macías, W | 1 |
| Belaunzarán, ML; Florin-Christensen, J; Florin-Christensen, M; Isola, EL; Lammel, EM; Wainszelbaum, MJ | 1 |
| Johnson, SW; Shen, KZ | 1 |
| Badwey, JA; Ge, Q; Ohira, T; VanDyke, T; Zhan, Q | 1 |
| Klink, M; Sulowska, Z; Tchorzewski, H | 1 |
| Huang, SH; Shen, WJ; Wang, SM; Yeo, HL | 1 |
| Cameron, P; Kanke, T; Macfarlane, SR; McKenzie, RC; Plevin, R; Sloss, CM | 1 |
| Labow, R; McBane, J; Santerre, P | 1 |
| Linsdell, P; McDonald, TF; Missan, S | 1 |
| Gobe, G; Johnson, DW; Li, J; Vesey, DA | 1 |
| An, R; Dong, X; Duan, G; Pan, S; Sun, X; Wang, Y | 1 |
| Cao, AL; Liu, HY; Zeng, WD; Zhang, CQ | 1 |
| Fuse, A; Morikawa, S; Murata, H; Sato, I; Sunohara, M | 1 |
| Pandey, N; Tripathi, D; Tripathi, P; Tripathi, YB | 1 |
| Gong, K; Li, J; Li, S; Lin, Q; Shao, G; Zhang, Y; Zhou, W | 1 |
| Chieng, YC; Hoon, LS; Hsum, YW; Mooi, LY; Soo, KK; Yew, WT | 1 |
| Chen, X; Li, P; Liu, D; Ning, Y; Peng, Y; Xiong, R; Yang, N; Zhao, Y; Zhou, Y | 1 |
2 review(s) available for tetradecanoylphorbol acetate and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
The regulation of excitability by second messengers and protein kinases in peptidergic neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Animals; Aplysia; Calcium; Calcium Channels; Enzyme Activation; Ion Channel Gating; Isoquinolines; Neurons; Neuropeptides; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinases; Protein Processing, Post-Translational; Second Messenger Systems; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Receptor associated phosphorylation following monoclonal antibody or synthetic peptide binding to nonspecific cytotoxic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Cytotoxicity, Immunologic; Genistein; Ictaluridae; Isoquinolines; Killer Cells, Natural; Molecular Sequence Data; Oxazolone; Peptides; Phosphorylation; Phosphoserine; Protein Kinase C; Quinolines; Serine; Sulfonamides; Tetradecanoylphorbol Acetate | 1998 |
731 other study(ies) available for tetradecanoylphorbol acetate and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Glutamates; Glutamic Acid; Growth Substances; Hippocampus; Ionomycin; Isoquinolines; Kainic Acid; Kinetics; Nerve Growth Factors; Nerve Tissue Proteins; Neurons; Nifedipine; Norepinephrine; Piperazines; Potassium; Protein Kinase Inhibitors; Quisqualic Acid; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1992 |
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Inositol Phosphates; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Second Messenger Systems; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Endothelin inhibits the atrial natriuretic factor stimulated cGMP production by activating the protein kinase C in rat aortic smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Cytosol; Endothelins; Enzyme Activation; Isoquinolines; Kinetics; Male; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Synergistic effects of 12-O-tetradecanoylphorbol-13-acetate and dexamethasone on de novo synthesis of histidine decarboxylase in mouse mastocytoma P-815 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Dexamethasone; Diglycerides; Drug Synergism; Enzyme Activation; Ethers, Cyclic; Histidine Decarboxylase; Isoquinolines; Mast-Cell Sarcoma; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
12-O-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid Phosphatase; Animals; Biomarkers; Bone Marrow; Bone Marrow Cells; Bone Resorption; Calcitonin; Calcitriol; Carcinogens; Cell Differentiation; Cells, Cultured; Isoquinolines; Kinetics; Macrophages; Microscopy, Electron, Scanning; Models, Biological; Osteoclasts; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Calcitonin; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1992 |
Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Animals; Blotting, Northern; Carcinoma, Ehrlich Tumor; Chlorides; Enzyme Induction; Isoquinolines; Lithium; Lithium Chloride; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Phorbol esters augment polyamine transport by influencing Na(+)-K+ pump in murine leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Isoquinolines; Leukemia L1210; Mice; Ouabain; Piperazines; Polyamines; Protein Kinase C; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate | 1992 |
Modulation of TNF-alpha-priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cinnamates; Diglycerides; Genistein; Guinea Pigs; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Opsonin Proteins; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Staurosporine; Sulfides; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Effects of antagonists of protein phosphatases on superoxide release by neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Guinea Pigs; Isoquinolines; Magnesium; Marine Toxins; Models, Biological; Neutrophils; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Piperazines; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
Participation of protein kinase C in desensitization to bradykinin and to carbachol in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Calcium; Carbachol; Cell Line; Cell Membrane; Dogs; Epithelium; Isoquinolines; Kidney; Kinetics; Microscopy, Fluorescence; Piperazines; Protein Kinase C; Receptors, Cell Surface; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Carrier Proteins; Cell Death; Clone Cells; DNA, Neoplasm; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-3; Isoquinolines; Kinetics; Leukemia, Megakaryoblastic, Acute; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Sodium-Hydrogen Exchangers; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Intracellular signal transduction in proliferation of synovial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Division; Cells, Cultured; Cyclic AMP; Cytokines; Dinoprostone; Humans; Interleukin-1; Isoquinolines; Piperazines; Protein Kinase C; Signal Transduction; Synovial Membrane; Tetradecanoylphorbol Acetate; Theophylline | 1992 |
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Erythropoietin; Humans; Isoquinolines; Liver Neoplasms; Oxygen; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Distribution; Tumor Cells, Cultured | 1992 |
Zygotic gene activation in the mouse embryo: involvement of cyclic adenosine monophosphate-dependent protein kinase and appearance of an AP-1-like activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aphidicolin; Cleavage Stage, Ovum; Cyclic AMP; Gene Expression Regulation; Isoquinolines; Mice; Microinjections; Oocytes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation | 1992 |
Retinoic acid and phorbol ester synergistically up-regulate IL-8 expression and specifically modulate protein kinase C-epsilon in human skin fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Cells, Cultured; Cyclic AMP; Drug Synergism; Enzyme Activation; Fibroblasts; Gene Expression; Humans; In Vitro Techniques; Interleukin 1 Receptor Antagonist Protein; Interleukin-8; Isoquinolines; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; RNA, Messenger; Sialoglycoproteins; Skin; Sulfonamides; Tetradecanoylphorbol Acetate; Tretinoin | 1992 |
Effect of tumor necrosis factor-alpha on the stimulus-coupled responses of neutrophils and their modulation by various inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Calcium; Dose-Response Relationship, Drug; Genistein; Humans; In Vitro Techniques; Isoflavones; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Recombinant Proteins; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha; Zymosan | 1992 |
Effect of protein kinase C inhibitors with different action mechanisms on Epstein-Barr virus replication.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; DNA, Viral; Herpesvirus 4, Human; Isoquinolines; Nucleic Acid Hybridization; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
The long-term combined stimulatory effects of ethanol and phorbol ester on phosphatidylethanolamine hydrolysis are mediated by a phospholipase C and prevented by overexpressed alpha-protein kinase C in fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Enzyme Activation; Ethanol; Ethanolamines; Ethers, Cyclic; Fibroblasts; Hydrolysis; Isoenzymes; Isoquinolines; Mice; Mice, Inbred BALB C; Okadaic Acid; Phosphatidylethanolamines; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1992 |
Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta, Thoracic; Biological Factors; Bucladesine; Cell Division; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Fibronectins; Isoquinolines; Kinetics; Macromolecular Substances; Muscle, Smooth, Vascular; Pertussis Toxin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Recombinant Proteins; Second Messenger Systems; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Virulence Factors, Bordetella | 1992 |
Evidence that the stimulation by arginine vasopressin of the release of adrenocorticotropin from the ovine anterior pituitary involves the activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Cells, Cultured; Corticotropin-Releasing Hormone; Enzyme Activation; Female; Isoquinolines; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Protein Kinase Inhibitors; Retinaldehyde; Sheep; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Protein phosphorylation regulates the mouse sperm acrosome reaction induced by the zona pellucida.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome; Alkaloids; Animals; Diglycerides; Ethers, Cyclic; Exocytosis; Female; Genistein; Isoflavones; Isoquinolines; Male; Membrane Fusion; Mice; Okadaic Acid; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Signal Transduction; Sperm-Ovum Interactions; Staurosporine; Tetradecanoylphorbol Acetate; Zona Pellucida | 1992 |
Effects of modulators of protein kinases and phosphatases on mouse sperm capacitation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bucladesine; Chlortetracycline; Dibutyryl Cyclic GMP; Diglycerides; Ethers, Cyclic; Fluorescence; Genistein; Isoflavones; Isoquinolines; Male; Mice; Okadaic Acid; Peptide Fragments; Phorbol Esters; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Sperm Capacitation; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Inhibition in L-type Ca2+ channel by stimulation of protein kinase C in isolated guinea pig ventricular cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channels; Electrophysiology; Female; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoquinolines; Male; Myocardium; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Alkaloids; Animals; Calcium; Carbohydrate Sequence; Cell Adhesion; Colon; Colonic Neoplasms; Entamoeba histolytica; Enzyme Activation; Humans; Intestinal Mucosa; Isoquinolines; Lectins; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Sequence Data; Mucins; Neoplasm Proteins; Piperazines; Protein Kinase C; Protozoan Proteins; Secretory Rate; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Cell Adhesion Molecules; Cell Survival; Cytokines; Drug Synergism; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Ionomycin; Isoquinolines; Lipopolysaccharides; Piperazines; Protein Biosynthesis; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester and atrial natriuretic peptide receptor response on vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Down-Regulation; Guanylate Cyclase; Isoquinolines; Muscle, Smooth, Vascular; Natriuretic Peptide, Brain; Nerve Tissue Proteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1992 |
Modulation of the antigenic phenotype of human breast carcinoma cells by modifiers of protein kinase C activity and recombinant human interferons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzyl Alcohols; Breast Neoplasms; Carcinoma; Cell Adhesion Molecules; Cell Division; Diterpenes; Female; Glycoproteins; Histocompatibility Antigens Class II; Humans; Intercellular Adhesion Molecule-1; Interferon Type I; Interferon-gamma; Isoquinolines; Phenotype; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Receptor, ErbB-2; Recombinant Proteins; Terpenes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Alpha 1-adrenergic stimulation of Na-H exchange in cardiac myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Carrier Proteins; Hydrogen-Ion Concentration; Isoquinolines; Myocardium; Norepinephrine; Piperazines; Protein Kinase C; Rats; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Membrane; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C regulates endothelial cell tube formation on basement membrane matrix, Matrigel.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood; Cell Differentiation; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Laminin; Neovascularization, Pathologic; Piperazines; Protein Kinase C; Proteoglycans; Tetradecanoylphorbol Acetate | 1992 |
Tumor promoters induce basic fibroblast growth factor gene expression in human dermal fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Cell Line; Diterpenes; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Fibroblasts; Gene Expression; Isoquinolines; Phorbol Esters; Piperazines; RNA, Messenger; Skin; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Basophils; Calcimycin; Glyceryl Ethers; Histamine Release; Humans; Indoles; Isoquinolines; Maleimides; Mannitol; Palmitoylcarnitine; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Dose-Response Relationship, Drug; Fimbriae, Bacterial; Gene Expression Regulation, Bacterial; Interleukin-8; Isoquinolines; Macrophages; Mice; Mice, Inbred BALB C; Neutrophils; Piperazines; Porphyromonas gingivalis; Protein Kinase C; RNA; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Cell Line; Colonic Neoplasms; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Membrane Proteins; Piperazines; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1992 |
Role of protein kinase C in transforming growth factor-beta 1 induction of carcinoembryonic antigen in human colon carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoembryonic Antigen; Colonic Neoplasms; Humans; Isoquinolines; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cell Division; Cell Line; Ceramides; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Ionomycin; Isomerism; Isoquinolines; Molecular Weight; Naphthalenes; Okadaic Acid; Phosphorylation; Piperazines; Polycyclic Compounds; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase C; Retinoblastoma Protein; Signal Transduction; Sphingosine; Tetradecanoylphorbol Acetate | 1992 |
Induction of ovulation and oocyte maturation of amphibian (Rana dybowskii) ovarian follicles by protein kinase C activation in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Cycloheximide; Enzyme Activation; Female; Isoquinolines; Oogenesis; Ovarian Follicle; Ovary; Ovulation Induction; Piperazines; Pituitary Gland; Progesterone; Protein Kinase C; Radioimmunoassay; Ranidae; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Drug Combinations; Insulin-Like Growth Factor I; Isoquinolines; Mitogens; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Thymidine | 1992 |
Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Analysis of Variance; Angiotensin II; Animals; Aorta; Arginine Vasopressin; Cell Membrane Permeability; Cells, Cultured; Digitonin; Diglycerides; Enzyme Activation; Glucose; Isoquinolines; Kinetics; Molecular Sequence Data; Muscle, Smooth, Vascular; Oligopeptides; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1992 |
Pathological phosphorylation causes neuronal death: effect of okadaic acid in primary culture of cerebellar granule cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cells, Cultured; Cerebellum; Ethers, Cyclic; Granulocytes; Isoquinolines; Neurons; Okadaic Acid; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1992 |
Transforming growth factor (TGF)-beta stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Animals; Cells, Cultured; Down-Regulation; Gene Expression Regulation; Genes, fos; Genes, jun; Isoquinolines; Liver; Mice; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1992 |
Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Ethers, Cyclic; Gene Expression Regulation, Leukemic; Genes, jun; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Male; Monocytes; Neoplasm Proteins; Neoplastic Stem Cells; Okadaic Acid; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Protein kinase C-dependent and -independent actions of a potent protein kinase C inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Epidermal Cells; Epidermis; Indomethacin; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Autoantigens; Calcium; Carcinoma, Squamous Cell; Carrier Proteins; Cell Membrane; Cells, Cultured; Collagen; Collagen Type XVII; Cytoskeletal Proteins; Desmosomes; Dystonin; Fluorescent Antibody Technique; Humans; Isoquinolines; Keratinocytes; Microscopy, Immunoelectron; Molecular Weight; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous; Piperazines; Protein Kinase C; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
[Sulfolipids and glycolipid sulfotransferases in a human renal cell carcinoma cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Renal Cell; Epidermal Growth Factor; Humans; Isoquinolines; Kidney Neoplasms; Lipid Metabolism; Lipids; Piperazines; Protein Kinase C; Staurosporine; Sulfotransferases; Sulfurtransferases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Processing and secretion of tumor necrosis factor alpha in endotoxin-treated Mono Mac 6 cells are dependent on phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cysteine; Dose-Response Relationship, Drug; Endotoxins; Humans; Isoquinolines; Kinetics; Lipopolysaccharides; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Staurosporine; Sulfur Radioisotopes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1992 |
Modulation of IK,Ca by phorbol ester-mediated activation of PKC in pleural sensory neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Ganglia; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Neurons, Afferent; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds | 1992 |
Cell proliferation and protooncogene induction in oligodendroglial progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Blotting, Northern; Cell Division; Cells, Cultured; Female; Genes, fos; Genes, jun; Immunohistochemistry; Isoquinolines; Oligodendroglia; Piperazines; Pregnancy; Protein Kinase Inhibitors; Proto-Oncogenes; Rats; Rats, Sprague-Dawley; Stem Cells; Tetradecanoylphorbol Acetate | 1992 |
Activation of protein kinase C stimulates collagenase production by cultured cells of the cervix of the pregnant guinea pig.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Cervix Uteri; Collagenases; Dinoprost; DNA Replication; Enzyme Activation; Enzyme Induction; Estradiol; Female; Guinea Pigs; Isoquinolines; Piperazines; Pregnancy; Pregnancy, Animal; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cycloheximide; Dactinomycin; Humans; Isoquinolines; Molecular Sequence Data; Neurites; Neuroblastoma; Neurofilament Proteins; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; RNA, Messenger; RNA, Neoplasm; Serum Albumin, Bovine; Tetradecanoylphorbol Acetate; Thrombin; Tumor Cells, Cultured | 1992 |
Phorbol ester reduces constitutive nuclear NF kappa B and inhibits HIV-1 production in mature human monocytic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cell Line; Cell Nucleus; Cells, Cultured; Enhancer Elements, Genetic; HIV-1; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Monocytes; NF-kappa B; Oligonucleotide Probes; Piperazines; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Virus Replication | 1992 |
Regulation of myeloid-specific calcium binding protein synthesis by cytosolic protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Calcitriol; Calcium-Binding Proteins; Calgranulin A; Calgranulin B; Cell Differentiation; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Isoquinolines; Leukemia; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tretinoin; Tumor Cells, Cultured | 1992 |
Influence of specific calmodulin and protein kinase C inhibitors on the interleukin 1 induced collagenase production in human uterine cervical fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cells, Cultured; Cervix Uteri; Collagenases; Culture Media, Conditioned; Enzyme Induction; Female; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Macrophages; Piperazines; Protein Kinase C; Rabbits; Rats; Recombinant Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1992 |
Mechanisms of norepinephrine mediated corticotropin-releasing factor-41 release from cultured fetal hypothalamic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Animals; Cells, Cultured; Corticotropin-Releasing Hormone; Dexamethasone; Dose-Response Relationship, Drug; Hypothalamus; Isoquinolines; Norepinephrine; Peptides; Pertussis Toxin; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1992 |
Classical conditioning and protein kinase C activation regulate the same single potassium channel in Hermissenda crassicornis photoreceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Conditioning, Classical; Enzyme Activation; In Vitro Techniques; Isoquinolines; Membrane Potentials; Phorbol 12,13-Dibutyrate; Photoreceptor Cells; Piperazines; Potassium Channels; Protein Kinase C; Snails; Tetradecanoylphorbol Acetate | 1992 |
Protein kinase C modulates cell swelling-induced Ca2+ influx and prolactin secretion in GH4C1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Line; Down-Regulation; Isoquinolines; Osmolar Concentration; Piperazines; Pituitary Gland; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1992 |
Characterization of the gonadotrophin-releasing hormone calcium response in single alpha T3-1 pituitary gonadotroph cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Cell Line; Gonadotropin-Releasing Hormone; Isoquinolines; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chloramphenicol O-Acetyltransferase; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; NF-kappa B; Piperazines; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, T-Cell; RNA, Neoplasm; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1992 |
Phorbol ester inhibits granulocyte-macrophage colony-stimulating factor binding and tyrosine phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tyrosine | 1992 |
Binding of NF-kB to the HIV-1 LTR is not sufficient to induce HIV-1 LTR activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Bridged-Ring Compounds; Cells, Cultured; Chloramphenicol O-Acetyltransferase; DNA Probes; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Viral; Gene Products, tat; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Isoquinolines; Molecular Sequence Data; NF-kappa B; Norbornanes; Piperazines; Plasmids; Protein Kinase C; Proviruses; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Transfection; Virus Activation | 1992 |
Study on the mechanism of Giardia lamblia induced diarrhoea in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcimycin; Calcium; Chlorides; Diarrhea; Giardia lamblia; Intestinal Mucosa; Isoquinolines; Mice; Piperazines; Protein Kinase C; Sodium; Tetradecanoylphorbol Acetate | 1992 |
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Base Sequence; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Interleukin-1; Interleukin-2; Interleukin-4; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Tumor Cells, Cultured | 1992 |
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Cell Differentiation; Cell Division; Cell Line; Flow Cytometry; Humans; Interleukin-2; Isoenzymes; Isoquinolines; Phenotype; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymidine | 1992 |
Protein kinase C activation during corneal endothelial wound repair.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Movement; Cells, Cultured; Endothelium, Corneal; Enzyme Activation; Epidermal Growth Factor; Fluorescent Antibody Technique; Fluorescent Dyes; Isoquinolines; Male; Phalloidine; Piperazines; Protein Kinase C; Rabbits; Rhodamines; Sphingosine; Tetradecanoylphorbol Acetate; Wound Healing | 1992 |
Disruption of endothelial actin microfilaments by protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Alkaloids; Animals; Cell Count; Cells, Cultured; Endothelium, Vascular; Image Processing, Computer-Assisted; Isoquinolines; Phalloidine; Piperazines; Protein Kinase C; Rhodamines; Staurosporine; Swine; Tetradecanoylphorbol Acetate | 1992 |
Induction of tissue factor synthesis in human umbilical vein endothelial cells involves protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Diglycerides; Endothelium, Vascular; Endotoxins; Humans; Interleukin-1; Isoquinolines; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboplastin | 1992 |
Regulation of inositol transport by glucose and protein kinase C in mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport, Active; Cells, Cultured; Glomerular Mesangium; Glucose; Hyperglycemia; Inositol; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1992 |
Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Animals; Calcium; Cattle; Humans; Hypercalcemia; Hyperparathyroidism; Hyperplasia; Isoquinolines; Parathyroid Diseases; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Uremia | 1992 |
Protein kinase C is involved in PTH-induced homologous desensitization by directly affecting PTH receptor in the osteoblastic osteosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP; GTP-Binding Proteins; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Growth factor-like effect of urokinase type plasminogen activator in human renal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cells, Cultured; DNA Replication; Growth Substances; Humans; Isoquinolines; Kidney Glomerulus; Kinetics; Pertussis Toxin; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tetradecanoylphorbol Acetate; Thymidine; Urokinase-Type Plasminogen Activator; Virulence Factors, Bordetella | 1991 |
Signal transduction pathways in the induction of HLA class I antigen expression on Huh 6 cells by interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calmodulin; Carcinoma, Hepatocellular; Cell Line; Cyclic CMP; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Liver Neoplasms; Piperazines; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Desensitization of the epidermal adenylate cyclase system: agonists and phorbol esters desensitize by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Epidermis; Epinephrine; Histamine; Isoquinolines; Pertussis Toxin; Piperazines; Receptors, Adrenergic, beta; Receptors, Histamine; Skin; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Retinoic acid enhances IL-1 beta expression in myeloid leukemia cells and in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Bucladesine; Gene Expression; Humans; Interleukin-1; Isoquinolines; Leukemia, Myeloid; Lipopolysaccharides; Monocytes; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured | 1991 |
Effect of lithium on function and growth of thyroid cells in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Division; Cell Line; Colforsin; Cyclic AMP; Iodides; Isoquinolines; Lithium; Piperazines; Protein Kinase C; Rats; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Triiodothyronine | 1991 |
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Brain; CD4 Antigens; Cyclic AMP; Down-Regulation; Interleukin-2; Isoquinolines; Lymphocyte Activation; Mice; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Receptors, Antigen, T-Cell; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C, an endogenous regulator of hormone-induced cyclic AMP induction in porcine luteal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Colforsin; Colistin; Corpus Luteum; Cyclic AMP; Female; Isoquinolines; Luteinizing Hormone; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Sphingosine; Swine; Tetradecanoylphorbol Acetate | 1991 |
Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Drug Tolerance; Glioma; Hydrolysis; Isoquinolines; Lithium; Lithium Chloride; Phosphatidylinositols; Piperazines; Pituitary Gland; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1991 |
Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Blotting, Western; Cells, Cultured; Glucose; Hypoglycemia; Insulin; Insulin Resistance; Isoquinolines; Male; Phosphorylation; Piperazines; Polymyxin B; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Induction of Epstein-Barr virus lytic cycle by tumor-promoting and non-tumor-promoting phorbol esters requires active protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Carcinogens; Cell Line; Cell Line, Transformed; Herpesvirus 4, Human; Humans; Isoquinolines; Kinetics; Lysogeny; Molecular Structure; Phorbol Esters; Piperazines; Protein Kinase C; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1991 |
Induction of interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and tumor necrosis factor-alpha. Involvement of protein kinase-dependent and adenylate cyclase-dependent regulatory pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Cyclic AMP; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Infant, Newborn; Interleukin-1; Isoquinolines; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Skin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Protein kinase C is not involved in the desensitization of platelet activating factor receptor in rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Platelets; Cell Membrane; Guanosine Triphosphate; Inositol Phosphates; Isoquinolines; Kinetics; Neomycin; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Tetradecanoylphorbol Acetate | 1991 |
Radiation-induced surface IgG modulation: protein kinase C involvement.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Immunoglobulin G; In Vitro Techniques; Isoquinolines; Mice; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Inhibition of pyroglutamyl peptidase II synthesis by phorbol ester in the Y-79 retinoblastoma cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Membrane; Humans; Immunoblotting; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calmodulin; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporins; Cytochalasins; Egtazic Acid; HIV-1; Humans; In Vitro Techniques; Isoquinolines; Lymphocyte Activation; Nerve Tissue Proteins; Pertussis Toxin; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Phentolamine; Piperazines; Propranolol; Pulmonary Artery; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Verapamil; Xanthine Oxidase | 1991 |
Transactivation of the TPA-responsive element by the oncogenic C-erbB-2 protein is partly mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Gene Expression; Growth Hormone; Isoquinolines; Kinetics; Mice; Phosphorylation; Piperazines; Plasmids; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; Receptor, ErbB-2; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection | 1991 |
Activation of high-affinity uptake of glutamate by phorbol esters in primary glial cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Calcimycin; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Drug Synergism; Glutamates; Glutamic Acid; Isoquinolines; Kinetics; Neuroglia; Neurons; Piperazines; Tetradecanoylphorbol Acetate | 1991 |
Ganglioside GQ1b-induced terminal differentiation in cultured mouse keratinocytes. Phosphoinositide turnover forms the onset signal.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcium; Cell Differentiation; Cells, Cultured; DNA; Gangliosides; Growth Substances; Inositol 1,4,5-Trisphosphate; Isoquinolines; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphatidylinositols; Piperazines; Signal Transduction; Tetradecanoylphorbol Acetate; Transglutaminases | 1991 |
Carbamylcholine and phorbol esters desensitize muscarinic receptors by different mechanisms in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Calcimycin; Carbachol; Dose-Response Relationship, Drug; Down-Regulation; Gallic Acid; Isoquinolines; Male; Pancreas; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Secretory Rate; Tetradecanoylphorbol Acetate | 1990 |
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibody Formation; B-Lymphocytes; Bryostatins; Calcimycin; Cell Cycle; Cyclosporins; DNA; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Lactones; Lymphocyte Activation; Macrolides; Piperazines; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate | 1990 |
A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chloramphenicol O-Acetyltransferase; Cycloheximide; Gene Expression; Humans; Interleukin-1; Interleukin-2; Isoquinolines; Kinetics; Mice; Nucleic Acid Hybridization; Piperazines; Plasmids; Promoter Regions, Genetic; Protein Kinase C; RNA; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Inhibition of protein kinase C induces differentiation in Neuro-2a cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholinesterase; Animals; Cell Differentiation; Cell Division; DNA; Isoquinolines; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuroblastoma; Piperazines; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate; Time Factors; Tubulin; Tumor Cells, Cultured | 1990 |
Loss of channel modulation by transmitter and protein kinase C during innervation of an identified leech neuron.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Electric Conductivity; Ion Channels; Isoquinolines; Kinetics; Leeches; Models, Neurological; Neurons; Piperazines; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate | 1990 |
The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Survival; Histamine Release; Immunoglobulin E; Isoquinolines; Leukotrienes; Mast Cells; Piperazines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Protein tyrosine phosphorylation in rabbit peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Calcium; Immunoblotting; Isoquinolines; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Quantitative analysis of CD5 antigen modulation by 12-O-tetradecanoylphorbol-13-acetate in T-lymphoblastic leukemia cells: individual response patterns and their relationships with both maturation and protein kinase C content.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; CD5 Antigens; Cell Cycle; Cell Differentiation; Cell Division; Diglycerides; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Leukemia, T-Cell; Phenotype; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Dissimilar effects of the protein kinase C inhibitors, staurosporine and H-7, on cholecystokinin-induced enzyme secretion from rabbit pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cholecystokinin; In Vitro Techniques; Isoquinolines; Pancreas; Piperazines; Protein Kinase C; Rabbits; Secretory Rate; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Effects of H7 and staurosporine on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcium; Carbachol; Cytosol; Isoquinolines; Kinetics; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Evidence for protein kinase C--independent pathways mediating phorbol ester induced plasmacytoid differentiation of B chronic lymphocytic leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; B-Lymphocytes; Cell Differentiation; Cell Division; DNA; Fluorescent Antibody Technique; Gene Expression; Humans; Immunoglobulin M; Isoquinolines; Leukemia, Lymphocytic, Chronic, B-Cell; Piperazines; Plasma Cells; Protein Kinase C; RNA; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Cell Compartmentation; E-Selectin; Endothelium, Vascular; Enzyme Activation; Histocompatibility Antigens Class I; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Phosphoproteins; Piperazines; Protein Biosynthesis; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Calcimycin; Carbachol; DNA Probes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzymes; Isoquinolines; Lipase; Nucleic Acid Hybridization; Pancreas; Pancreatic Elastase; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Involvement of protein kinase C in competence induction of macrophages to generate T suppressor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Epitopes; Histocompatibility Antigens Class II; Immunocompetence; Interferon-gamma; Interleukin-1; Interleukin-6; Isoquinolines; Macrophages; Mice; Piperazines; Protein Kinase C; Protein Kinases; T-Lymphocytes, Regulatory; Tetradecanoylphorbol Acetate | 1991 |
Regulation of Na(+)-Ca2+ exchange in cultured human mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Calcium; Cell Line; Culture Media; Endothelins; Fura-2; Glomerular Mesangium; Gramicidin; Homeostasis; Humans; Insulin; Ionophores; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Sodium; Spectrometry, Fluorescence; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1991 |
Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Atrial Natriuretic Factor; Cells, Cultured; Cyclic GMP; Glomerular Mesangium; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Phorbol-12-myristate-13-acetate (PMA) and inhibitors of protein kinase C alter glial fibrillary acidic protein (GFAP) mRNA levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Astrocytoma; Dactinomycin; Glial Fibrillary Acidic Protein; Humans; Isoquinolines; Piperazines; Protein Kinase C; RNA; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1991 |
Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; DNA Probes; Gene Expression Regulation, Neoplastic; Isoquinolines; Kinetics; Piperazines; Pituitary Neoplasms; Poly A; Protein Kinase C; Rats; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; RNA; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1991 |
Involvement of protein kinase C in angiotensin II-mediated release of 12-hydroxyeicosatetraenoic acid in bovine adrenal glomerulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Angiotensin II; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Diglycerides; Hydroxyeicosatetraenoic Acids; Isoquinolines; Piperazines; Protein Kinase C; Radioimmunoassay; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Zona Glomerulosa | 1991 |
Effect of protein kinase C activators on the phosphorylation and the surface expression of the CDw50 leukocyte antigen.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Antigens, Differentiation; Cell Adhesion Molecules; Concanavalin A; Cross-Linking Reagents; Diterpenes; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Flow Cytometry; Fluorescent Antibody Technique; Humans; Isoquinolines; Kinetics; Lymphocytes; Phorbol 12,13-Dibutyrate; Phosphorylation; Phytohemagglutinins; Piperazines; Precipitin Tests; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1992 |
Regulation of NF-kappa B activity in murine macrophages: effect of bacterial lipopolysaccharide and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line; DNA; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Isoquinolines; Kinetics; Lipopolysaccharides; Macrophages; Mice; Molecular Sequence Data; Molecular Weight; NF-kappa B; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1992 |
Greater importance of Ca(2+)-calmodulin in maintenance of ang II- and K(+)-mediated aldosterone secretion: lesser role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium; Calmodulin; Cattle; Diglycerides; Dose-Response Relationship, Drug; Egtazic Acid; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitrendipine; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1992 |
Dual effects of a phorbol ester on calcium-dependent chloride secretion by T84 epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Line; Chlorides; Colon; Humans; Intestinal Mucosa; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase Inhibitors; Rubidium; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Phagocytosis of Giardia lamblia trophozoites by cytokine-activated macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Calcimycin; Cells, Cultured; Cytokines; Giardia lamblia; In Vitro Techniques; Interferon-gamma; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred C3H; Phagocytosis; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1992 |
Modulation of synovial fibroblast plasminogen activator and plasminogen activator inhibitor production by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Diterpenes; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Lyngbya Toxins; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Protein Kinase C; RNA, Messenger; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1991 |
Basic fibroblast growth factor requires a long-lasting activation of protein kinase C to induce cell proliferation in transformed fetal bovine aortic endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies; Aorta; Cattle; Cell Division; Cell Line, Transformed; Endothelium, Vascular; Enzyme Activation; Fibroblast Growth Factor 2; Isoquinolines; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1991 |
Inhibition of protein kinase C is associated with a decrease in c-myc expression in human myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cell Line; Enzyme Activation; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Isoquinolines; Kinetics; Leukemia, Myeloid; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; RNA, Messenger; RNA, Neoplasm; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Interferon type I and II antagonism: a novel regulatory mechanism of indoleamine dioxygenase induction in human peripheral blood monocytes and peritoneal macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Induction; Humans; Interferon alpha-2; Interferon-alpha; Interferon-beta; Interferon-gamma; Isoquinolines; Leukocytes, Mononuclear; Macrophages; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tryptophan Oxygenase | 1991 |
Signal transduction in endotoxin-stimulated synthesis of TNF-alpha and prostaglandin E2 by rat Kupffer cells. Role of extracellular calcium ions and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Dinoprostone; Egtazic Acid; Endotoxins; Interferon-gamma; Isoquinolines; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; Salmonella; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
Control of nucleoside transport in neural cells. Effect of protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adrenal Medulla; Animals; Biological Transport; Calcimycin; Caprylates; Cells, Cultured; Diglycerides; Dinucleoside Phosphates; Enzyme Activation; Ethers, Cyclic; Isoquinolines; Kinetics; Okadaic Acid; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Triglycerides | 1991 |
Protein kinase C stimulation enhances the process formation of adult oligodendrocytes and induces proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Brain; Cell Division; Cells, Cultured; Glial Fibrillary Acidic Protein; Isoquinolines; Microscopy, Electron; Microscopy, Electron, Scanning; Nerve Regeneration; Oligodendroglia; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate | 1991 |
Phorbol myristate acetate inhibits phosphoinositol lipid-specific phospholipase C activity via protein kinase C activation in conditions inducing differentiation in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Membrane; Clone Cells; Enzyme Activation; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Isoquinolines; Leukemia, Myeloid; Lipid Metabolism; Piperazines; Protein Kinase C; Staurosporine; Streptolysins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Type C Phospholipases | 1991 |
Phorbol ester and phospholipase C-mediated differentiated thyroid function in vitro: the effects of protein kinase C inhibition and downregulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Down-Regulation; Isoquinolines; Phorbol Esters; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Type C Phospholipases | 1991 |
Prostacyclin secretion and specific intracellular protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Bradykinin; Calcimycin; Cattle; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Heat-Shock Proteins; Hot Temperature; Isoquinolines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Secretory Rate; Staurosporine; Tamoxifen; Tetradecanoylphorbol Acetate | 1991 |
Phorbol ester-induced expression of the common, low-affinity binding site for primary prostanoids in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Isoquinolines; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Receptors, Thromboxane; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1991 |
Translocation of CD45RA in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Cell Membrane; Flow Cytometry; Gene Expression Regulation; Histocompatibility Antigens; Humans; Isoantigens; Isoquinolines; Leukocyte Common Antigens; Neutrophils; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 1991 |
GM-CSF and phorbol esters modulate GM-CSF receptor expression by independent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Down-Regulation; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Isoquinolines; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Possible involvement of protein phosphorylation in the regulation of the sulphonylurea receptor of a pancreatic beta-cell line, HIT T15.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Colforsin; Diazoxide; Glyburide; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Phosphorylation; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase Inhibitors; Proteins; Receptors, Drug; Rubidium; Sulfonylurea Receptors; Tetradecanoylphorbol Acetate | 1991 |
IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Calcimycin; Calmodulin; Gene Expression Regulation; Histocompatibility Antigens Class II; Interferon-gamma; Ionomycin; Isoquinolines; Macrophages; Major Histocompatibility Complex; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Trifluoperazine; Tumor Necrosis Factor-alpha | 1991 |
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Bicarbonates; Biological Transport; Calcium Channel Blockers; Dose-Response Relationship, Drug; Gallic Acid; Isoquinolines; Kidney Tubules, Proximal; Male; Perfusion; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Signal Transduction; Sodium; Tetradecanoylphorbol Acetate | 1991 |
Inhibition by phorbol ester of cellular adenosine 3',5'-monophosphate production and cellular free calcium mobilization in response to arginine vasopressin in rat renal papillary collecting tubule cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Isoquinolines; Kidney Medulla; Kidney Tubules, Collecting; Male; Osmolar Concentration; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Regulation of Fc gamma receptor subtype expression on a human eosinophilic leukemia cell line EoL-3: participation of cAMP and protein kinase C in the effects of interferon-gamma and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation; Bucladesine; Calcium; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Eosinophils; Flow Cytometry; Humans; Immunoglobulin G; In Vitro Techniques; Interferon-gamma; Isoquinolines; Leukemia, Eosinophilic, Acute; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Protein kinase C is not involved in alpha 1-adrenoceptor-mediated positive inotropic effect.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Electric Conductivity; Hydrolysis; Isoquinolines; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1991 |
Involvement of protein kinase C in regulating tumor necrosis factor alpha-stimulated progesterone production in rat preovulatory follicles in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Female; In Vitro Techniques; Isoquinolines; Ovarian Follicle; Ovulation; Piperazines; Progesterone; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1991 |
The role of protein kinase C activation and inositol phosphate production in the regulation of cell-surface expression of Mac-1 by complement fragment C5a.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Complement C5a; Cytoplasm; Enzyme Activation; Humans; Inositol Phosphates; Isoquinolines; Kinetics; Macrophage-1 Antigen; Oxygen; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Phorbol ester induces desensitization of PTH-stimulated cyclic AMP production by decreasing the PTH receptor binding in UMR-106 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Cyclic AMP; Isoquinolines; Parathyroid Hormone; Piperazines; Protein Kinase C; Rats; Receptors, Cell Surface; Receptors, Parathyroid Hormone; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Exogeneous diacylglycerols downregulate the activity of Na(+)-K+ pump in Xenopus laevis oocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Biological Transport, Active; Cell Membrane; Diglycerides; Female; In Vitro Techniques; Isoquinolines; Kinetics; Oocytes; Piperazines; Protein Kinase C; Rubidium; Sodium; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Xenopus laevis | 1991 |
Decreased respiratory burst activity in neonatal bovine neutrophils stimulated by protein kinase C agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Female; Isoquinolines; Neutrophils; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclase Inhibitors; Affinity Labels; Animals; Cell Line; Cell Membrane; Cloning, Molecular; Cricetinae; Cricetulus; Humans; Isoquinolines; Phosphorylation; Photochemistry; Piperazines; Precipitin Tests; Protein Kinase C; Receptors, Serotonin; Sphingosine; Tetradecanoylphorbol Acetate | 1991 |
Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Down-Regulation; Enzyme Activation; Gene Expression Regulation; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1991 |
Carbachol-stimulated phosphorylation of a 170-kDa endogenous protein in avian salt gland cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Atropine; Carbachol; Ducks; Ionomycin; Isoquinolines; Kinetics; Molecular Weight; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Proteins; Salt Gland; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
Microglial cell-mediated anti-Candida activity: temperature, ions, protein kinase C as crucial elements.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Candida albicans; Cell Line, Transformed; Central Nervous System; Diglycerides; Immunity, Cellular; Ions; Isoquinolines; Macrophages; Magnesium; Phagocytosis; Piperazines; Protein Kinase C; Temperature; Tetradecanoylphorbol Acetate | 1991 |
The protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) inhibits PMA-induced promiscuous cytolytic activity but not specific cytolytic activity by a cloned cytolytic T lymphocyte.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Clone Cells; Cytotoxicity, Immunologic; Isoquinolines; Lethal Dose 50; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperazines; Protein Kinase C; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 1991 |
Possible implication of arachidonic acid metabolism in the decrease of chemiluminescence production after exposure of murine peritoneal macrophages to diethylnitrosamine and tumour promoter, 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cell Survival; Culture Media; Cyclooxygenase Inhibitors; Diethylnitrosamine; Dose-Response Relationship, Drug; Extracellular Space; Female; Indomethacin; Intracellular Fluid; Isoquinolines; Kinetics; Leukotrienes; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Oxygen; Peritoneal Cavity; Phospholipids; Piperazines; Prostaglandins; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tritium | 1991 |
Inhibition of high-affinity gamma-aminobutyric acid uptake in primary astrocyte cultures by phorbol esters and phospholipase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Bacillus cereus; Biological Transport; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1991 |
Calcium oscillation induced by bradykinin in polyoma middle T antigen-transformed NIH3T3 fibroblasts: evidence for dependence on protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Polyomavirus Transforming; Bradykinin; Cadmium; Cadmium Chloride; Calcium; Cell Line, Transformed; Egtazic Acid; Fibroblasts; Fura-2; Imidazoles; Isoquinolines; Mice; Mice, Inbred Strains; Oscillometry; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Protein kinase C in tumoricidal activation of mouse macrophage cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cytotoxicity, Immunologic; Diglycerides; Enzyme Activation; Female; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Mast-Cell Sarcoma; Mice; Mice, Inbred BALB C; Phosphatidylserines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Protein kinase C activation mimics but does not mediate thyrotropin-induced desensitization of adenylyl cyclase in cultured dog thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Dogs; Enzyme Activation; GTP-Binding Proteins; Isoquinolines; Kinetics; Pertussis Toxin; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Virulence Factors, Bordetella | 1991 |
Possible involvement of protein kinase C in gonadotropin and growth hormone release from dispersed goldfish pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Diglycerides; Egtazic Acid; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Growth Hormone; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Pituitary Gland; Protein Kinase C; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Protein kinase C regulates MHC-class II expression on endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Endothelium; Histocompatibility Antigens Class II; Interferon-gamma; Isoquinolines; Myocardium; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Time Factors | 1991 |
Suppression of c-fos precursor RNA splicing by the protein kinase C inhibitor H7 [1-(5-isoquinolinesulphonyl)-2-methylpiperazine].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Gene Expression; Isoquinolines; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; RNA Precursors; RNA Splicing; Tetradecanoylphorbol Acetate | 1991 |
Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Calcimycin; Camptothecin; Cell Survival; Cells, Cultured; Cycloheximide; Dactinomycin; Endotoxins; Enterotoxins; Enzyme Activation; Isoquinolines; Macrophages; Male; Piperazines; Protein Biosynthesis; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1991 |
Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Blood; Cell Line; Cytokines; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression; Genes, fos; Genes, jun; Hydrogen Peroxide; Immediate-Early Proteins; Isoquinolines; Mice; Molecular Sequence Data; Osteoblasts; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 1991 |
Phorbol myristate acetate corrects impaired NK function of old mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Cell Adhesion; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoquinolines; Killer Cells, Natural; Mice; Mice, Inbred C3H; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate | 1991 |
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlorides; Diarrhea; Enterotoxins; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance | 1991 |
Norepinephrine-induced phosphatidylcholine hydrolysis in intact rat aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hydrolysis; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phosphatidylcholines; Phospholipase D; Phosphorylcholine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1991 |
Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Aminoquinolines; Animals; Biological Transport; Cells, Cultured; Cycloheximide; Glucose; Glyburide; Glycogen; Islets of Langerhans; Isoquinolines; Muscles; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Stimulation of synthesis de novo of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Western; Dimethyl Sulfoxide; Dinoprostone; Enzyme Activation; Enzyme Induction; Humans; Hydroxyprostaglandin Dehydrogenases; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; NAD; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometrium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cyclic AMP; Female; Inositol Phosphates; Isoproterenol; Isoquinolines; Myometrium; Phosphatidylinositols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Inbred Strains; Relaxin; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbohydrates; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; Gene Expression Regulation, Enzymologic; Glucokinase; Hormones; Isoenzymes; Isoquinolines; Liver; Male; Piperazines; Protein Kinase C; Pyruvate Kinase; Rats; Rats, Inbred Strains; RNA, Messenger; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Detergents; Egtazic Acid; Enzyme Activation; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Octoxynol; Peritoneal Cavity; Piperazines; Polyethylene Glycols; Protamine Kinase; Protein Kinase C; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Modulation of melanocyte intercellular adhesion molecule-1 by immune cytokines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Factors; Cell Adhesion Molecules; Cells, Cultured; Cytokines; Flow Cytometry; Fluorescent Antibody Technique; Humans; Infant, Newborn; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1; Isoquinolines; Kinetics; Male; Melanocytes; Piperazines; Protein Kinase Inhibitors; Receptors, Virus; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1990 |
Rapid inactivation and phosphorylation of pyroglutamyl peptidase II in Y-79 human retinoblastoma cells after exposure to phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Epinephrine; Eye Neoplasms; Humans; Immune Sera; Immunoblotting; Isoquinolines; Kinetics; Molecular Weight; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Pyroglutamyl-Peptidase I; Retinoblastoma; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Involvement of a protein kinase C-dependent process in long-term potentiation formation in guinea pig superior colliculus slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Electric Stimulation; Enzyme Activation; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Isoquinolines; Melitten; Piperazines; Polymyxin B; Protein Kinase C; Superior Colliculi; Tetany; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Signal transduction and the regulation of actin conformation during myeloid maturation: studies in HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Bryostatins; Calcium; Cell Differentiation; Dimethyl Sulfoxide; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Lactones; Macrolides; Microscopy, Electron, Scanning; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Ethers, Cyclic; Glycogen Synthase Kinase 3; Isoquinolines; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Phosphoproteins; Piperazines; Protein Kinase C; Protein Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Antigen-induced phospholipase D activation in rat mast cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antigens, Helminth; Ascaris; Enzyme Activation; Enzyme Induction; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Mast Cells; Myristic Acid; Myristic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
WS-1 human fibroblasts contain distinct calcium and protein kinase C-mediated pathways for activation of Na+/H+ exchange: contrasting effects of thrombin and PMA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amiloride; Biological Transport; Calcium; Cells, Cultured; DNA Replication; Enzyme Activation; Fibroblasts; Humans; Hydrogen; Hydrogen-Ion Concentration; Isoquinolines; Piperazines; Protein Kinase C; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1991 |
A rapid colorimetric microassay to detect agonists/antagonists of protein kinase C based on adherence of EL-4.IL-2 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Carcinogens; Cell Adhesion; Colorimetry; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Indoles; Isoquinolines; Lactams; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Reproducibility of Results; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thymoma; Tumor Cells, Cultured | 1991 |
Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Humans; Isoquinolines; Kinetics; Nerve Degeneration; Neurons; Phorbol Esters; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1991 |
Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Isoquinolines; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Palmitoylcarnitine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1991 |
Suppression of phorbol ester-enhanced radiation-induced malignancy in vitro by protease inhibitors is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cytosol; DNA Replication; Isoquinolines; Kinetics; Mice; Mice, Inbred C3H; Piperazines; Protease Inhibitors; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Time Factors; Tosylphenylalanyl Chloromethyl Ketone; X-Rays | 1991 |
Dioctanoylglycerol regulation of cytosolic Ca2+ by protein kinase C-independent mechanism in HIT T-15 islet cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cricetinae; Cytosol; Diglycerides; Ethanol; Islets of Langerhans; Isoquinolines; Kinetics; Mesocricetus; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Aorta; Calcimycin; Endothelium, Vascular; Enzyme Activation; Glucose; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Vasodilation | 1991 |
Phosphorylation of membrane-associated proteins by phorbol esters in isolated bag cell neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Cell Membrane; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Isoquinolines; Membrane Proteins; Neurons; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Trypsin | 1991 |
Characterization of Pichinde virus infection of cells of the monocytic lineage.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Viral; Arenaviridae; Cell Differentiation; Cells, Cultured; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Monocytes; Piperazines; Receptors, Virus; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Viral Proteins; Virus Replication | 1991 |
Different activation signals are required for the expression of interleukin-1 alpha and beta genes in human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Interleukin-1; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Monocytes; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1991 |
Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line; DNA; Interleukin-1; Isoquinolines; Lipopolysaccharides; Mice; Molecular Sequence Data; NF-kappa B; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Role of protein kinase C in adriamycin-induced erythroid differentiation of K562 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Differentiation; Cell Division; Cell Line; Culture Techniques; Doxorubicin; Erythroid Precursor Cells; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1991 |
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cell Line; DNA Mutational Analysis; Isoquinolines; Macromolecular Substances; Molecular Sequence Data; Mutation; Phorbol 12,13-Dibutyrate; Piperazines; Piperidines; Protein Conformation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1991 |
v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibiotics, Antineoplastic; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Fibroblasts; Gene Expression; Genes, src; Immediate-Early Proteins; Isoquinolines; Mice; Mice, Inbred BALB C; Phenotype; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Pyrimidine Nucleosides; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors | 1991 |
Endotoxin-mediated bovine alveolar macrophage procoagulant induction is dependent on protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Coagulation Factors; Cattle; Endotoxins; Enzyme Activation; Isoquinolines; Lipopolysaccharides; Macrophages; Phenylbutazone; Piperazines; Protein Kinase C; Pulmonary Alveoli; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thromboplastin | 1990 |
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Egtazic Acid; Exocytosis; Interphase; Isoquinolines; Oocytes; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Xenopus laevis | 1990 |
Biochemical analyses of the inhibition of catecholamine release by tetanus toxin in digitonin-permeabilized chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Chromaffin System; Digitonin; Humans; Isoquinolines; Norepinephrine; Piperazines; Tetanus Toxin; Tetradecanoylphorbol Acetate | 1990 |
Differential sensitivity of pancreatic beta-cells to phorbol ester TPA and C-kinase inhibitor H-7 in nonpregnant and pregnant rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Piperazines; Pregnancy; Pregnancy, Animal; Protein Kinase C; Rats; Rats, Inbred Strains; Reference Values; Tetradecanoylphorbol Acetate | 1990 |
Activation of protein kinase C by myristate and its requirements of Ca2+ and phospholipid.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Brain; Calcium; Cytoplasm; Enzyme Activation; Guinea Pigs; In Vitro Techniques; Isoquinolines; NADH, NADPH Oxidoreductases; Nerve Tissue Proteins; Phospholipids; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1990 |
Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Calcimycin; Cells, Cultured; Dinoprostone; Eicosanoids; Female; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Pertussis Toxin; Piperazines; SRS-A; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cells, Cultured; Fatty Acids; Humans; Isoquinolines; Linoleic Acid; Linoleic Acids; Neutrophils; Oleic Acid; Oleic Acids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Nuclear pp64 is phosphorylated in both serine/threonine and tyrosine through complex pathways regulated by 12-O-tetradecanoylphorbol-13-acetate and platelet-derived growth factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dimethyl Sulfoxide; Epidermal Growth Factor; Isoquinolines; Kinetics; Nuclear Proteins; Phosphorylation; Piperazines; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Serine; Tetradecanoylphorbol Acetate; Threonine; Tyrosine | 1990 |
Differences between the mechanisms of action of heat-stable and heat-labile enterotoxins of Escherichia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bacterial Toxins; Biological Transport, Active; Calcimycin; Calcium; Calmodulin; Chlorides; Enterotoxins; Escherichia coli; Escherichia coli Proteins; Ileum; Isoquinolines; Mice; Piperazines; Protein Kinase C; Sodium; Tetradecanoylphorbol Acetate | 1990 |
Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Calmodulin; CD4 Antigens; Cytochalasin B; Cytoplasm; Demecolcine; Down-Regulation; Egtazic Acid; Isoquinolines; Mice; Mice, Inbred BALB C; Phosphorylation; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tubulin | 1990 |
Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Arachidonic Acids; Calcimycin; Cells, Cultured; Dinoprost; Dinoprostone; Endothelium, Vascular; Epoprostenol; Humans; Ionomycin; Isoquinolines; Phorbol Esters; Phospholipases A; Phospholipases A2; Piperazines; Platelet Activating Factor; Prostaglandin D2; Prostaglandins H; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bryostatins; Calcimycin; Cell Differentiation; Enzyme Activation; Gene Expression; Humans; Isoquinolines; Kinetics; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Piperazines; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogenes; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Inhibition by protein kinase-C inhibitor and cycloheximide of phorbol ester- and epidermal growth factor-induced arachidonic acid metabolism in cultured porcine thyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Isoquinolines; Kinetics; Male; Mice; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland | 1990 |
Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Line; Diglycerides; Glucose; Glycerol; Inositol; Insecticides; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Mice; Mice, Inbred BALB C; Myristic Acid; Myristic Acids; Phosphates; Piperazines; Protein Kinase Inhibitors; Pyrethrins; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Role of Ca2+/phospholipid-dependent protein kinase in catecholamine secretion from bovine adrenal medullary chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Catecholamines; Cattle; Cells, Cultured; Digitonin; Down-Regulation; Enterochromaffin Cells; Isoquinolines; Piperazines; Polymyxin B; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Nordihydroguaiaretic acid inhibits urokinase synthesis by phorbol myristate acetate-stimulated LLC-PK1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Cell Line; Enzyme Precursors; Fatty Acids, Unsaturated; Isoquinolines; Kinetics; Masoprocol; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Protein Kinase C; Pyrazoles; Tetradecanoylphorbol Acetate; Urokinase-Type Plasminogen Activator | 1990 |
Signal transduction of a tissue interaction during embryonic heart development.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Chick Embryo; Cholera Toxin; Endothelium; Enzyme Activation; Extracellular Matrix Proteins; Fetal Heart; Genistein; GTP-Binding Proteins; Isoflavones; Isoquinolines; Myocardium; Pertussis Toxin; Phenotype; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1990 |
Signal transduction in endothelin-induced contraction of rabbit pulmonary vein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Endothelins; In Vitro Techniques; Isoquinolines; Nifedipine; Norepinephrine; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Pulmonary Veins; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Vasoconstrictor Agents; Verapamil | 1990 |
Inhibition of receptor-mediated calcium influx in T cells by unsaturated non-esterified fatty acids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Fatty Acids, Nonesterified; Humans; Isoquinolines; Nickel; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Role of intracellular calcium concentration and protein kinase C activation in IFN-gamma stimulation of U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation; Antigens, Differentiation, Myelomonocytic; Antigens, Surface; Biological Transport; Calcium; Cell Compartmentation; Cell Line; Enzyme Activation; Gallic Acid; HLA-DR Antigens; Humans; Inositol 1,4,5-Trisphosphate; Interferon-gamma; Ionomycin; Isoquinolines; Macrophage-1 Antigen; Macrophages; Piperazines; Protein Kinase C; Receptors, Complement; Receptors, Fc; Receptors, IgG; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Anti-CD3 antibody-induced activated killer cells subsets of killer cells that mediate fast or slow lytic reactions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cytotoxicity, Immunologic; Female; Immunophenotyping; Isoquinolines; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Subsets; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Phorbol 12-myristate 13-acetate (TPA) blocks CD3-mediated Ca2+ mobilization in Jurkat T cells independently of protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Calcium; CD3 Complex; Cell Line; Fura-2; Humans; Inositol; Inositol Phosphates; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Antigen, T-Cell; Spectrometry, Fluorescence; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1990 |
Rapid increase of the human IFN-gamma receptor phosphorylation in response to human IFN-gamma and phorbol myristate acetate. Involvement of different serine/threonine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Humans; In Vitro Techniques; Interferon-gamma; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Protein Kinases; Receptors, Immunologic; Receptors, Interferon; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1990 |
Chemotactic peptide enhancement of phorbol ester-induced protein kinase C activity in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cytochalasin B; Diglycerides; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Induction of transcription from the long terminal repeat of Moloney murine sarcoma provirus by UV-irradiation, x-irradiation, and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Line; Cells, Cultured; Cycloheximide; Gene Expression Regulation, Viral; Genes, Viral; Isoquinolines; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Nucleic Acid Hybridization; Piperazines; Protein Kinase C; Proviruses; Repetitive Sequences, Nucleic Acid; RNA, Viral; Sarcoma Viruses, Murine; Tetradecanoylphorbol Acetate; Ultraviolet Rays; X-Rays | 1990 |
Modes of inhibitory action of 4 beta-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane Permeability; Chlorides; Colforsin; Cyclic AMP; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Piperazines; Protein Kinase Inhibitors; Rabbits; Serotonin; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thrombin | 1990 |
Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Diacylglycerol Kinase; Humans; In Vitro Techniques; Isoquinolines; Lipase; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases; Piperazines; Protein Kinase C; Quinacrine; Tetracaine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester treatment stimulates tyrosine phosphorylation of a sea urchin egg cortex protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Ammonium Chloride; Animals; Carrier Proteins; Egg Proteins; Female; Hydrogen-Ion Concentration; Isoquinolines; Molecular Weight; Ovum; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Sea Urchins; Signal Transduction; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Tyrosine | 1990 |
Protein kinase C is involved in desensitization of muscarinic receptors induced by phorbol esters but not by receptor agonists.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cyclic GMP; Down-Regulation; Isoquinolines; Mice; N-Methylscopolamine; Neuroblastoma; Parasympathomimetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Effect of second-messenger modulators in K-562 cell differentiation: dual action of calcium/phospholipid-dependent protein kinase in the process of differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cell Differentiation; Cell Division; Cell Survival; Cytarabine; Diglycerides; Erythropoiesis; Globins; Hemin; Humans; In Vitro Techniques; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Pharmacological modification of mechanical and electrical responses of frog heart to thrombin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Barium; Barium Compounds; Calcium Channels; Chlorides; Electrophysiology; Enzyme Activation; Heart; In Vitro Techniques; Isoquinolines; Myocardial Contraction; Piperazines; Protein Kinase C; Rana esculenta; Tetradecanoylphorbol Acetate; Thrombin; Vasoconstriction | 1990 |
A central role for phosphoinositide hydrolysis in activating the lytic mechanism of human natural killer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cytosol; Cytotoxicity, Immunologic; Diacylglycerol Kinase; Humans; Hydrolysis; Inositol Phosphates; Isoquinolines; Killer Cells, Natural; Neomycin; Phosphatidylinositols; Phosphotransferases; Piperazines; Protein Kinase C; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Divergent activities of protein kinases in IL-6-induced differentiation of a human B cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; B-Lymphocytes; Cell Differentiation; Cell Line; Cyclic AMP; Humans; Immunoglobulin M; Interleukin-6; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinases; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cyclic AMP; Down-Regulation; Enzyme Activation; Gene Products, gag; Isoquinolines; Oncogene Proteins v-mos; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Retroviridae Proteins, Oncogenic; Tetradecanoylphorbol Acetate; Thionucleotides | 1990 |
Effects of phorbol ester on cell growth inhibition by transforming growth factor beta 1 in human hepatoma cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Carcinoma, Hepatocellular; Cell Division; DNA; Epithelial Cells; Growth Inhibitors; Humans; In Vitro Techniques; Isoquinolines; Liver Neoplasms; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Transforming Growth Factors; Tumor Cells, Cultured | 1990 |
Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Models, Chemical; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; Staurosporine; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Evidence for protein kinase C involvement in the regulation of renal 25-hydroxyvitamin D3-24-hydroxylase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Calcifediol; Calcitriol; Cyclic AMP; Cytochrome P-450 Enzyme System; Cytosol; Diglycerides; Enzyme Induction; Homeostasis; Isoquinolines; Kidney Cortex; Kidney Tubules; Kinetics; Male; Mice; Mice, Inbred C57BL; Mitochondria; Phosphorylation; Piperazines; Protein Kinase C; Steroid Hydroxylases; Tetradecanoylphorbol Acetate; Vitamin D3 24-Hydroxylase | 1990 |
Regulation of Ki-ras expression in Reuber H35 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; Diglycerides; DNA Probes; Egtazic Acid; Gene Expression Regulation, Neoplastic; Genes, ras; Glucagon; Isoquinolines; Kinetics; Liver Neoplasms, Experimental; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Control of interleukin-1 beta expression by protein kinase C and cyclic adenosine monophosphate in myeloid leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Colforsin; Cyclic AMP; Dinoprostone; Enzyme Activation; Gene Expression; Humans; Interleukin-1; Isoquinolines; Leukemia, Myeloid; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
MDL 27,032 [4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone], an active site-directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenosine Triphosphate; Animals; Binding Sites; Brain; Chickens; Dogs; Female; Femoral Artery; Isoenzymes; Isoquinolines; Kinetics; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rats; Saphenous Vein; Tetradecanoylphorbol Acetate | 1990 |
Diacylglycerols and PMA are particularly effective stimulators of fluid pinocytosis in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Chemotaxis, Leukocyte; Colchicine; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Nocodazole; Oligopeptides; Pinocytosis; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Effects of intraperitoneally administered dietary fibers on superoxide generation from peritoneal exudate macrophages in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Dietary Fiber; Isoquinolines; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred C3H; Oxygen; Peritoneum; Phagocytosis; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Phorbol 12-myristate 13-acetate, A23187 and L-adrenaline inhibit phospholipid methylation in human monocytes and lymphocytes. Inhibition is independent of oxyradical production and phospholipid hydrolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Epinephrine; Free Radicals; Humans; Hydrolysis; Isoquinolines; Lymphocytes; Methylation; Monocytes; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Piperazines; Protein Kinase Inhibitors; S-Adenosylmethionine; Sodium Fluoride; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; DNA, Viral; Down-Regulation; Enhancer Elements, Genetic; Enzyme Activation; H-2 Antigens; HIV-1; Humans; Isoquinolines; Leukemia; Molecular Sequence Data; NF-kappa B; Phorbol 12,13-Dibutyrate; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Necrosis Factor-alpha | 1990 |
Modulation of vincristine sensitivity of human kidney tumor cells by pharmacological agents interfering with intracellular signals. No apparent relationship to changes in cytoplasmic Ca2+ or pH.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Calcium; Colforsin; Cytoplasm; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Sensitivity and Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vincristine | 1990 |
Protein kinase C activators selectively inhibit insulin-stimulated system A transport activity in skeletal muscle at a post-receptor level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-O-Methylglucose; Aminoisobutyric Acids; Animals; Biological Transport; Enzyme Activation; In Vitro Techniques; Insulin; Isoquinolines; Lactates; Male; Methylglucosides; Muscles; Piperazines; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred Strains; Receptor, Insulin; Tetradecanoylphorbol Acetate | 1990 |
Modulation of c-myc gene expression by extracellular stimuli in rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Concanavalin A; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Gene Expression; Insulin; Insulin Antagonists; Isoquinolines; Liver Neoplasms, Experimental; Piperazines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Tumor necrosis factor production by Kupffer cells requires protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Dinoprostone; Enzyme Activation; Escherichia coli; Isoquinolines; Kupffer Cells; Lipopolysaccharides; Macrophage Activation; Mice; Mice, Inbred BALB C; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1990 |
Possible contribution of protein kinase C activation to priming for DNA synthesis induced by epidermal growth factor with insulin and its inhibition by plasma membrane in primary cultured rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; DNA; DNA Replication; Enzyme Activation; Epidermal Growth Factor; Insulin; Isoquinolines; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Vasopressins | 1990 |
Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Colonic Neoplasms; Dose-Response Relationship, Drug; Humans; Isoquinolines; Lymphotoxin-alpha; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Different effects of TPA on two skin-derived cell lines: murine (HEL-30) and human (NCTC) epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Cell Line; Humans; Isoquinolines; L-Lactate Dehydrogenase; Mice; Ornithine Decarboxylase; Piperazines; Protein Kinase C; Receptors, Drug; Skin; Species Specificity; Tetradecanoylphorbol Acetate | 1990 |
Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Biological Transport; Cell Line; Cell Separation; Deoxyglucose; Hexoses; Insulin; Isoquinolines; Male; Muscles; Piperazines; Protein Kinase C; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Cadherins; Cell Adhesion Molecules; Cell Adhesion Molecules, Neuronal; Cells, Cultured; Chick Embryo; Extracellular Matrix Proteins; Ganglia, Parasympathetic; Isoquinolines; Laminin; Neurons; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; DNA; Down-Regulation; Drug Synergism; Fibroblasts; Growth Substances; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1990 |
Evidence that protein kinase C activation is essential for killing by IL-2-activated lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Chromium Radioisotopes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Interleukin-2; Isoquinolines; Killer Cells, Lymphokine-Activated; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1990 |
Stimulation of phospholipase D activity by phorbol esters in cultured astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Biomechanical Phenomena; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Glycerophospholipids; In Vitro Techniques; Isoquinolines; Phosphatidic Acids; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1990 |
Vasoactive intestinal peptide stimulates active K+ transport and Na(+)-K(+)-Cl- cotransport in HT-29 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Amiloride; Biological Transport; Bumetanide; Carrier Proteins; Cell Line; Chlorides; Colonic Neoplasms; Humans; Isoquinolines; Kinetics; Norepinephrine; Ouabain; Piperazines; Potassium; Protein Kinase C; Sodium-Potassium-Chloride Symporters; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide; Yohimbine | 1990 |
Effects of activators and inhibitors of protein kinase C on two-stage transformation in BALB/3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diglycerides; Drug Antagonism; Enzyme Activation; Glycerides; Isoquinolines; Methylcholanthrene; Mice; Palmitoylcarnitine; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester-induced expression of the common, low-affinity binding site for primary prostanoids in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Aorta, Thoracic; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dinoprost; Fatty Acids, Unsaturated; Hydrazines; Isoquinolines; Kinetics; Male; Muscle, Smooth, Vascular; Piperazines; Prostaglandins; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Tetradecanoylphorbol Acetate | 1990 |
Ca2(+)-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adult; Alkaloids; Calcium; Cell Membrane Permeability; Cytoplasmic Granules; Electric Stimulation; Glucuronidase; Humans; Isoquinolines; Kinetics; Lysosomes; Magnesium; Neutrophils; Piperazines; Proadifen; Protein Kinase C; Ribonucleotides; Staurosporine; Tetradecanoylphorbol Acetate; Transcobalamins | 1990 |
Positive and negative regulation of a tumor necrosis factor response in melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; DNA Probes; Female; Humans; Isoquinolines; Kinetics; Melanoma; Phorbol 12,13-Dibutyrate; Piperazines; Plasminogen Activators; Plasminogen Inactivators; Pregnancy; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1990 |
Role of protein kinase C in chick embryo skeletal myoblast fusion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Calcium; Cell Fusion; Chick Embryo; Diglycerides; Enzyme Activation; Isoquinolines; Muscles; Piperazines; Protein Kinase C; Protein Kinases; Pyrimidinones; Tetradecanoylphorbol Acetate; Thiazoles | 1990 |
Regulation of angiotensin II binding sites in neuronal cultures by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Animals, Newborn; Brain Stem; Cells, Cultured; Homeostasis; Hypothalamus; Isoquinolines; Kinetics; Neurons; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Tetradecanoylphorbol Acetate | 1990 |
Synergistic effect of phorbol myristate acetate on bacterial lipopolysaccharide induced rat splenocyte proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Drug Synergism; In Vitro Techniques; Isoquinolines; Lipopolysaccharides; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Spleen; Tetradecanoylphorbol Acetate; Thymidine; Time Factors | 1990 |
Muscarinic receptor-mediated translocation of calmodulin in SK-N-SH human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Biological Transport; Calcium; Calmodulin; Carbachol; Humans; Ionomycin; Isoquinolines; Kinetics; Neuroblastoma; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1990 |
Phorbol esters induce neurotransmitter release in cholinergic synaptosomes from Torpedo electric organ.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Botulinum Toxins; Dose-Response Relationship, Drug; Electric Organ; Isoquinolines; Kinetics; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Synaptosomes; Tetradecanoylphorbol Acetate; Torpedo | 1990 |
Diacylglycerol and protein kinase mediated noradrenergic responses in perfused rat kidneys.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Diglycerides; Glomerular Filtration Rate; Gluconeogenesis; Glycerides; In Vitro Techniques; Isoquinolines; Kidney; Kidney Tubules; Male; Norepinephrine; Perfusion; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains; Renal Circulation; Sphingosine; Staurosporine; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Vascular Resistance | 1990 |
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Blotting, Southern; Cell Division; Humans; Isoquinolines; Melanocytes; Melanoma; Piperazines; Protein Kinase C; Protein Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate | 1990 |
Role of protein kinase C in renal vasoconstriction caused by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Cobalt; Enzyme Inhibitors; Imidazoles; Isoquinolines; Male; Nifedipine; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Staurosporine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil | 1990 |
Protein kinase C is present in human sperm: possible role in flagellar motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Alkaloids; Antibodies, Monoclonal; Humans; Immunohistochemistry; Isoquinolines; Kinetics; Male; Piperazines; Protein Kinase C; Reference Values; Sperm Motility; Spermatozoa; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1990 |
Contrasting effects of phorbol dibutyrate and phorbol myristate acetate in rabbit aorta.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cells, Cultured; Epinephrine; In Vitro Techniques; Isoquinolines; Liver; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphates; Phosphatidylinositols; Piperazines; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate | 1990 |
Phorbol ester-mediated induction of HIV-1 from a chronically infected promonocyte clone: blockade by protein kinase inhibitors and relationship to tat-directed trans-activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Aminopurine; Adenine; Alkaloids; Cell Line; Clone Cells; Gene Products, tat; HIV-1; Humans; Idoxuridine; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Piperazines; Protein Kinase Inhibitors; Staurosporine; tat Gene Products, Human Immunodeficiency Virus; Tetradecanoylphorbol Acetate; Trans-Activators; Transcriptional Activation; Virus Replication | 1990 |
Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 48/80 in mast cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Histamine Release; Inositol; Isoquinolines; Mast Cells; p-Methoxy-N-methylphenethylamine; Phorbols; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1985 |
1,2-Diacylglycerol, protein kinase C, and pancreatic enzyme secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcimycin; Carbachol; Dibutyryl Cyclic GMP; Diglycerides; Glycerides; Guinea Pigs; In Vitro Techniques; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase C; Sincalide; Tetradecanoylphorbol Acetate; Tetragastrin | 1986 |
Specific inhibition of phorbol ester and DiC8-induced histamine release from human basophils by the protein kinase C inhibitors, H-7 and H-9.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Basophils; Calcimycin; Calmodulin; Diglycerides; Glycerides; Histamine Release; Humans; Immunoglobulin E; In Vitro Techniques; Isoquinolines; Kinetics; Perphenazine; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
Biphasic effects of 12-O-tetradecanoylphorbol-13-acetate on the cell morphology of low calcium-grown human epidermal carcinoma cells: involvement of translocation and down regulation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Carcinoma, Squamous Cell; Cell Division; Cell Line; Culture Media; Humans; Isoquinolines; Keratins; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
The role of protein kinase C on amylase secretion from rat parotid gland.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amylases; Animals; Diglycerides; Isoquinolines; Parotid Gland; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1988 |
Effects of a phorbol ester, a calcium ionophore, and 3',5'-adenosine monophosphate production on hen granulosa cell plasminogen activator activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Chickens; Cyclic AMP; Cycloheximide; Dactinomycin; Female; Granulosa Cells; In Vitro Techniques; Isoquinolines; L-Lactate Dehydrogenase; Luteinizing Hormone; Piperazines; Plasminogen Activators; Progesterone; Protein Kinase C; Sheep; Tetradecanoylphorbol Acetate | 1988 |
The influence of tetradecanoyl-phorbol-acetate (TPA) on histamine release from isolated rat mast cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Diglycerides; Histamine Release; Isoquinolines; Male; Mast Cells; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Tumor-promoting phorbol esters support the in vitro proliferation of murine pluripotent hematopoietic stem cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colony-Forming Units Assay; Colony-Stimulating Factors; Dose-Response Relationship, Drug; Erythropoietin; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cells; Indomethacin; Interleukin-3; Isoquinolines; Mice; Phorbols; Piperazines; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Interaction of signal transduction pathways in mediating acid secretion by rat parietal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Bucladesine; Cell Membrane; Diglycerides; Female; Gastric Acid; Histamine; Isoquinolines; Parietal Cells, Gastric; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1989 |
Effects of protein kinase inhibitor, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, on beta-2 adrenergic receptor activation and desensitization in intact human lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adult; Cyclic AMP; Drug Synergism; Humans; Iodocyanopindolol; Isoproterenol; Isoquinolines; Lymphocytes; Pindolol; Piperazines; Protein Kinase Inhibitors; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate | 1989 |
Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte; B-Lymphocytes; Humans; Immunoglobulin M; Isoquinolines; Lymphocyte Activation; Peptide Fragments; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Antigen, B-Cell; Sulfonamides; Tetradecanoylphorbol Acetate; Trypsin | 1989 |
Activators of protein kinase C up-regulate the cell surface expression of CD2 and CD5 T cell glycoproteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation; Antigens, Differentiation, T-Lymphocyte; Calcium Channel Blockers; CD2 Antigens; CD5 Antigens; Cell Membrane; Cells, Cultured; Cycloheximide; Diglycerides; Dinoprostone; Enzyme Activation; Flow Cytometry; Humans; Isoquinolines; Membrane Glycoproteins; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Receptors, Immunologic; RNA, Messenger; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Calcimycin; Calcium; Cerebral Cortex; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Inbred F344; Serotonin; Tetradecanoylphorbol Acetate | 1989 |
Phorbol ester, 1,2-diacylglycerol, and collagen induce inhibition of arachidonic acid incorporation into phospholipids in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Acylglycerophosphocholine O-Acyltransferase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Coenzyme A Ligases; Collagen; Diglycerides; Enzyme Activation; Glycerides; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1989 |
Temporal and pharmacological division of fibroblast cyclooxygenase expression into transcriptional and translational phases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cells, Cultured; Dexamethasone; Fibroblasts; Humans; Interleukin-1; Isoquinolines; Kinetics; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Protein Kinase Inhibitors; Skin; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1989 |
Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cell Nucleus; Cells, Cultured; Cytosol; DNA; Isoquinolines; Kinetics; Male; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thymus Gland | 1989 |
Protein kinase C and the stimulation of tissue plasminogen activator release from human endothelial cells. Dependence on the elevation of messenger RNA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Cloning, Molecular; Colforsin; Cycloheximide; DNA; Endothelium, Vascular; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; RNA, Messenger; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1989 |
Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cell Survival; Cycloheximide; Dactinomycin; DNA Damage; Isoquinolines; Lectins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peanut Agglutinin; Phenotype; Piperazines; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Induction of multinucleated giant cell formation from human blood-derived monocytes by phorbol myristate acetate in in vitro culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Fusion; Cells, Cultured; DNA; Humans; Interferon-gamma; Isoquinolines; Macrophages; Monocytes; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1989 |
Induction of high-affinity interleukin 2 receptors on human T lymphocytes. The role of calcium and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Diglycerides; Egtazic Acid; Ethers; Humans; Interleukin-2; Ionomycin; Isoquinolines; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Modulation of calcium-induced eicosanoid synthesis in mouse peritoneal macrophages by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Dinoprostone; Fatty Acids, Unsaturated; In Vitro Techniques; Isoquinolines; Macrophages; Mice; Mice, Inbred DBA; Piperazines; Protein Kinase C; SRS-A; Tetradecanoylphorbol Acetate | 1989 |
Comparison of effects of protein kinase C inhibitors on phorbol ester-induced CD4 down-regulation and augmentation of human immunodeficiency virus replication in human T cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; CD4 Antigens; Cell Line; Down-Regulation; Flow Cytometry; Gene Products, gag; HIV; HIV Antigens; HIV Core Protein p24; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Viral Core Proteins; Virus Replication | 1989 |
Endothelial inositol phosphate generation and prostacyclin production in response to G-protein activation by AlF4-.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Aluminum; Aluminum Compounds; Arachidonic Acids; Calcimycin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Female; Fluorides; Fluorine; GTP-Binding Proteins; Humans; Inositol Phosphates; Isoquinolines; Kinetics; Pertussis Toxin; Piperazines; Pregnancy; Protein Kinase C; Signal Transduction; Sodium Fluoride; Tetradecanoylphorbol Acetate; Umbilical Veins; Virulence Factors, Bordetella | 1989 |
Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding, Competitive; Cell Line; Cytosol; Immunosuppressive Agents; Interleukin-1; Interleukin-2; Isoquinolines; Mice; Peptide Fragments; Piperazines; Protein Kinase C; Receptors, Immunologic; Receptors, Interleukin-1; Retroviridae Proteins; Serum Albumin, Bovine; Signal Transduction; Tetradecanoylphorbol Acetate; Thymoma | 1989 |
Protein kinase C modulates effects of prostanoids on cyclic adenosine monophosphate in guinea pig chief cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Isoquinolines; Male; Pepsinogens; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Radioimmunoassay; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
Na+-H+ antiport during fertilization of the sea urchin egg is blocked by W-7 but is insensitive to K252a and H-7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Carbazoles; Carrier Proteins; Female; Fertilization; Indole Alkaloids; Isoquinolines; Kinetics; Ovum; Piperazines; Protein Kinase C; Sea Urchins; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Effect of granulocyte-macrophage colony-stimulating factor on superoxide production in cytoplasts and intact human neutrophils: role of protein kinase and G-proteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Botulinum Toxins; Colony-Stimulating Factors; Cytoplasm; Cytoskeletal Proteins; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; GTP-Binding Proteins; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1989 |
Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acids; Calcium; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Neutrophils; Piperazines; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene B4; SRS-A; Tetradecanoylphorbol Acetate | 1989 |
Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Astrocytes; Cells, Cultured; Cyclic AMP; Enzyme Inhibitors; Isoquinolines; Molecular Weight; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Inbred Strains; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Enhancement of adenosine A2 and prostaglandin E1 receptor-mediated cAMP generation by prior exposure of Swiss 3T3 fibroblasts to Ca2+-mobilizing receptor agonists or phorbol ester. Activation of protein kinase C triggers increases in the receptor density
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Alkaloids; Animals; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Diglycerides; Enzyme Activation; Fibroblasts; Isoquinolines; Kinetics; Mice; Piperazines; Prostaglandins E; Protein Kinase C; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Epidermis; Isoquinolines; Osmolar Concentration; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Cell Surface; Swine; Tetradecanoylphorbol Acetate | 1989 |
Defining the role of protein kinase C in epinephrine- and bradykinin-stimulated arachidonic acid metabolism in Madin-Darby canine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Cell Line; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Epinephrine; Isoquinolines; Kidney; Piperazines; Protein Kinase C; Receptors, Adrenergic, alpha; Receptors, Bradykinin; Receptors, Neurotransmitter; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channels; Cell Compartmentation; Cell Differentiation; Diglycerides; Enzyme Activation; Humans; Isoquinolines; Membrane Potentials; Neuroblastoma; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Muscarinic; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1989 |
Protein kinase C blockers and neutrophil receptors for leukotriene B4.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Piperazines; Platelet Activating Factor; Protein Kinase C; Receptors, Immunologic; Receptors, Leukotriene B4; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Thermodynamics | 1989 |
The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Bucladesine; Calcium; Cattle; Cell Division; Cell Line; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Fibroblast Growth Factors; Isoquinolines; Kinetics; Piperazines; Plasminogen Activators; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 1989 |
A role for protein kinase C in the membrane fusion necessary for platelet granule secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Blood Platelets; Calcimycin; Carrier Proteins; Cytoplasmic Granules; Diglycerides; Humans; In Vitro Techniques; Isoquinolines; Membrane Fusion; Membrane Potentials; Phosphoproteins; Piperazines; Platelet Aggregation; Protein Kinase C; Sodium-Hydrogen Exchangers; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Diacylglycerols and the protein kinase inhibitor H-7 suppress cell polarity and locomotion of Walker 256 carcinosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinoma 256, Walker; Cell Compartmentation; Cell Movement; Colchicine; Diglycerides; Dose-Response Relationship, Drug; Glycerides; Isoquinolines; Leukotriene B4; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Triggering of neutrophil cytotoxicity against an antibody-coated tumour target by TPA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Cell Degranulation; Egtazic Acid; Humans; Isoquinolines; Leukemia; Muramidase; Neutrophils; Piperazines; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Protein kinase C is involved in laminin stimulation of neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Chick Embryo; Concanavalin A; Cyclic AMP; Extracellular Matrix; Ganglia, Parasympathetic; Isoquinolines; Laminin; Motor Neurons; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Involvement of protein kinase C in activation of human granulocytes and peritoneal macrophages by type 1 fimbriated (mannose specific) Escherichia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carbazoles; Escherichia coli; Fimbriae, Bacterial; Granulocytes; Indole Alkaloids; Isoquinolines; Luminescent Measurements; Macrophage Activation; Macrophages; Mannose; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Epidermis; Isoquinolines; Mice; Ornithine Decarboxylase; Phosphorylation; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
The role of protein kinase-C in sensitization and antigen response of airway smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Antibody Specificity; Antigens; Carbazoles; Guinea Pigs; Histamine; Immunization; Immunoglobulin G; Indoles; Indomethacin; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Ovalbumin; Piperazines; Potassium Chloride; Protein Kinase C; Tetradecanoylphorbol Acetate; Trachea | 1989 |
Tumor promotion and depletion of protein kinase C in epidermal JB6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Epidermis; Immunoblotting; Isoquinolines; Peptide Fragments; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Activation and desensitization mechanisms of muscarinic current response in single pancreatic acinar cells of rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Electrophysiology; Inositol Phosphates; Isoquinolines; Male; Pancreas; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1989 |
Protein kinase C is not involved in secretion by permeabilized human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Cell Membrane Permeability; Diglycerides; Glucuronidase; Humans; Isoquinolines; Lysosomes; Magnesium; Muramidase; Neutrophils; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcobalamins; Type C Phospholipases | 1989 |
Heterogeneity of responses to LH-releasing hormone and phorbol ester among rat gonadotrophs: a study using a reverse haemolytic plaque assay for LH.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Gonadotropin-Releasing Hormone; Hemolytic Plaque Technique; Isoquinolines; Luteinizing Hormone; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Inbred Strains; Retinaldehyde; Tetradecanoylphorbol Acetate; Time Factors | 1989 |
1,25-Dihydroxyvitamin D3 regulation of c-myc protooncogene transcription. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcitriol; Cell Differentiation; Cell Line; Cell Nucleus; Ethanol; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1989 |
Regulation of eicosanoid synthesis in mouse peritoneal macrophages by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acids; Diglycerides; Dinoprostone; Isoquinolines; Macrophages; Mice; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Induction of plasminogen activator activity by phorbol ester in transformed fetal bovine aortic endothelial cells. Possible independence from protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cattle; Cell Line, Transformed; Diglycerides; Endothelium, Vascular; Enzyme Activation; Fetus; Isoquinolines; Mitogens; Piperazines; Plasminogen Activators; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Effect of H-7 on the modulation of glucagon actions by activators of protein kinase-C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arginine Vasopressin; Cells, Cultured; Drug Interactions; Female; Glucagon; Hypothyroidism; Isoquinolines; Liver; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Urea | 1989 |
Molecular mechanisms of lymphocyte extravasation. III. The loss of lymphocyte extravasation potential induced by pertussis toxin is not mediated via the activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Surface; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Dermatitis, Contact; Dinitrofluorobenzene; Endothelium, Lymphatic; Enzyme Activation; Immunization, Passive; Intestines; Isoquinolines; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred C3H; Pertussis Toxin; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1989 |
Desensitization of inositol phosphate production after agonist stimulation of endothelial cells is not mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Histamine; Humans; Inositol Phosphates; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Sugar Phosphates; Tetradecanoylphorbol Acetate; Thrombin | 1989 |
Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, Surface; Carcinogens; Cell Adhesion; Cell Adhesion Molecules; Diterpenes; Endothelium, Vascular; Enzyme Activation; Humans; Isoquinolines; Kinetics; Membrane Glycoproteins; Phorbol Esters; Piperazines; Protein Kinase C; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1989 |
Alteration of intracellular actin levels induced by phorboldiester in human HL-60 leukemia cells susceptible or resistant to differentiation, and the effects of protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Antibodies, Monoclonal; Antigen-Antibody Reactions; Cell Differentiation; Cell Line; Cytoplasm; Drug Resistance; Humans; Isoquinolines; Leukemia, Promyelocytic, Acute; Macrophages; Neoplasm Proteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Differential phosphorylation of the nucleoprotein of influenza A viruses.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Animals; Chick Embryo; Influenza A virus; Isoquinolines; Nucleoproteins; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Species Specificity; Tetradecanoylphorbol Acetate; Virus Replication | 1989 |
[The role of protein kinase C in left ventricular relaxation impaired by global ischemia].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Coronary Disease; Dogs; Isoquinolines; Myocardial Contraction; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1989 |
Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release in permeabilized pancreatic acinar cells by hormonal and phorbol ester pretreatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Cell Membrane Permeability; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Kinetics; Pancreas; Piperazines; Protein Kinase Inhibitors; Rabbits; Sincalide; Sugar Phosphates; Tetradecanoylphorbol Acetate | 1989 |
Secretagogues for lung surfactant increase lung uptake of alveolar phospholipids.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1,2-Dipalmitoylphosphatidylcholine; Animals; In Vitro Techniques; Isoquinolines; Kinetics; Lung; Male; Piperazines; Protein Kinase Inhibitors; Pulmonary Alveoli; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Terbutaline; Tetradecanoylphorbol Acetate | 1989 |
Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cell Line; Gossypol; Isoquinolines; Kinetics; Lymphoma; Piperazines; Prolactin; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Humans; Interleukin-2; Isoquinolines; Lymphocyte Activation; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 1987 |
Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Bucladesine; Calcitriol; Cell Differentiation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1988 |
TPA induction of Epstein-Barr virus early antigens in Raji cells is blocked by selective protein kinase-C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Antigens, Viral; Burkitt Lymphoma; Calmodulin; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1987 |
Phorbol diesters and dioctanoylglycerol stimulate accumulation of both diacylglycerols and alkylacylglycerols in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chlorpromazine; Diglycerides; Ethers; Glycerides; Glyceryl Ethers; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Neutrophils; Piperazines; Protein Kinase C; Sphingosine; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Dissociation of the 47-kilodalton protein phosphorylation from degranulation and superoxide production in neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylglucosaminidase; Animals; Cytochalasin B; Cytoplasmic Granules; Drug Interactions; Hexosaminidases; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Fluoride can activate the respiratory burst independently of Ca2+, stimulation of phosphoinositide turnover and protein kinase C translocation in primed human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Calcium; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen Consumption; Pertussis Toxin; Phosphatidylinositols; Piperazines; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1988 |
Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cytochalasin B; Enzyme Activation; Female; Humans; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Biochemical mechanisms involved in the priming of neutrophils by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Colony-Stimulating Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pertussis Toxin; Phosphorylation; Piperazines; Protein Kinase C; Sodium; Superoxides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 1988 |
Vasoactive intestinal peptide receptor/adenylate cyclase system: differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alkaloids; Animals; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Isoquinolines; Peptide PHI; Piperazines; Protein Kinase C; Receptors, Gastrointestinal Hormone; Receptors, Vasoactive Intestinal Peptide; Staurosporine; Tetradecanoylphorbol Acetate; Vasoactive Intestinal Peptide | 1988 |
Halothane, an inhalation anesthetic, activates protein kinase C and superoxide generation by neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cytoplasm; Enzyme Activation; Guinea Pigs; Halothane; Histones; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phosphatidylserines; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Physiological Phenomena; Calcium; Culture Media; Cyclic AMP; Enhancer Elements, Genetic; Humans; Isoquinolines; Mice; Oncogenes; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Signal Transduction; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1988 |
Calcitonin-induced increase in phosphate accumulation in LLC-PK1 cells probably through protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcitonin; Cells, Cultured; Cyclic AMP; Diglycerides; Isoquinolines; Kidney; Phorbol Esters; Phosphates; Piperazines; Protein Kinase C; Sulfonamides; Swine; Tetradecanoylphorbol Acetate | 1988 |
Arachidonic acid release is closely related to the Fc gamma receptor-mediated superoxide generation in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Glucose; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoquinolines; Macrophages; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Quinones; Receptors, Fc; Superoxides; Tetradecanoylphorbol Acetate | 1988 |
Induction of desensitization by phorbol ester to beta-adrenergic agonist stimulation in adenylate cyclase system of rat reticulocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Diglycerides; Guanylyl Imidodiphosphate; Isoproterenol; Isoquinolines; Male; Phorbols; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Reticulocytes; Tetradecanoylphorbol Acetate | 1986 |
Negative regulation of atrial natriuretic factor receptor coupled membrane guanylate cyclase by phorbol ester. Potential protein kinase C regulation of cyclic GMP signal in isolated adrenocortical carcinoma cells of rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Atrial Natriuretic Factor; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex Neoplasms; Animals; Carcinoma; Clonidine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Rats; Receptors, Adrenergic, alpha; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Effects of protein kinase C (PK-C) activators and inhibitors on human large granular lymphocytes (LGL): role of PK-C on natural killer (NK) activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Diglycerides; Enzyme Activation; Ethers; Humans; Immunity, Innate; Ionomycin; Isoquinolines; Killer Cells, Natural; Molecular Weight; Phosphoproteins; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1989 |
Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Abdomen; Action Potentials; Animals; Aplysia; Calcium; Electrophysiology; Ganglia; Isoquinolines; Neurons; Neuropeptides; Piperazines; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate | 1989 |
Role of protein kinase C in glial cell proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Cell Division; Cells, Cultured; DNA Replication; Enzyme Inhibitors; Isoquinolines; Neuroglia; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1989 |
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C5; Complement C5a; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Oxygen Consumption; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Reversal by protein kinase C inhibitor of suppressive actions of phorbol-12-myristate-13-acetate on polyphosphoinositide metabolism and cytosolic Ca2+ mobilization in thrombin-stimulated human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Phorbols; Phosphatidylinositols; Phosphoproteins; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1986 |
The inhibition of neutrophil responsiveness caused by phorbol esters is blocked by the protein kinase C inhibitor H7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcium; Cytosol; Exocytosis; Hexosaminidases; Isoquinolines; Leukotriene B4; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peritoneal Cavity; Phorbols; Phosphoproteins; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1986 |
Cell alkalinization is not necessary and increased sodium influx is not sufficient for stimulated superoxide production.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Hydrogen-Ion Concentration; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Rabbits; Sodium; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Effects of phorbol esters on protein phosphorylation and free T3 release by mouse thyroid lobes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Bucladesine; Electrophoresis, Polyacrylamide Gel; Female; Isoquinolines; Mice; Phorbol Esters; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Triiodothyronine | 1986 |
Identification of distinct activation pathways of the human neutrophil NADPH-oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Enzyme Activation; Humans; Indomethacin; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Piperazines; Pyrazoles; Quinacrine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1986 |
Induction and regulation of human interleukin 2 gene expression: significance of protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Enzyme Activation; Gene Expression Regulation; Humans; Interleukin-2; Isoquinolines; Lymphocytes; Mitoguazone; Ornithine; Phytohemagglutinins; Piperazines; Prostaglandins E; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine | 1986 |
Inhibition of neutrophil superoxide formation by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), and inhibitor of protein kinase-C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Cytoplasm; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1986 |
Rapid modulation of tumor necrosis factor membrane receptors by activators of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Cells, Cultured; Diglycerides; Glycoproteins; Humans; Isoquinolines; Lymphocyte Activation; Piperazines; Protein Kinase C; Receptors, Cell Surface; Receptors, Tumor Necrosis Factor; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1986 |
Comparison of the roles of calmodulin and protein kinase C in activation of the human neutrophil respiratory burst.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Piperazines; Protein Kinase C; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate; Trifluoperazine | 1987 |
The effect of a protein kinase C inhibitor, H-7, on human neutrophil oxidative burst and degranulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium-Binding Proteins; Cells, Cultured; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Phorbol ester-induced inhibition of cyclic GMP formation mediated by muscarinic receptors in murine neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carbachol; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Histamine; Isoquinolines; Mice; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Piperazines; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1987 |
Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Enzyme Activation; Guinea Pigs; Isoquinolines; Macrophages; NADH, NADPH Oxidoreductases; NADPH Oxidases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Receptors, Fc; Receptors, IgG; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1987 |
Calcium- and phospholipid-dependent protein kinase C and phosphatidylinositol kinase: two major phosphorylation systems in the cornea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Animals; Cornea; Cytosol; Egtazic Acid; Epithelium; Isoquinolines; Phosphatidylserines; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1987 |
Regulation of cell shape in the Cloudman melanoma cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-MSH; Animals; Axons; Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Fluorescent Antibody Technique; Isoquinolines; Melanocyte-Stimulating Hormones; Melanoma; Mice; Microscopy, Electron; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1987 |
Protein kinase C activators and bradykinin selectively inhibit vasopressin-stimulated cAMP synthesis in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Cell Line; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Glucagon; Isoquinolines; Piperazines; Prostaglandins E; Protein Kinase C; Tetradecanoylphorbol Acetate; Vasopressins | 1987 |
Biochemical basis of HLA-DR and CR3 modulation on human peripheral blood monocytes by lipopolysaccharide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Bucladesine; Calcium; Enzyme Activation; Gene Expression Regulation; HLA-D Antigens; HLA-DR Antigens; Humans; Isoquinolines; Lipopolysaccharides; Monocytes; Phosphatidylinositols; Piperazines; Protein Kinase C; Receptors, Complement; Receptors, Complement 3b; Tetradecanoylphorbol Acetate; Theophylline | 1987 |
Regulation of HLA class II antigen expression: intracellular signaling molecules responsible for the regulation by IFN-gamma and cross-linking of Fc receptors in HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Calcimycin; Calcium; Calmodulin; Cell Line; Cyclic AMP; Gene Expression Regulation; Histocompatibility Antigens Class II; Humans; Immunoglobulin G; Interferon-gamma; Isoquinolines; Leukemia, Myeloid, Acute; Male; Middle Aged; Piperazines; Protein Kinase C; Receptors, Fc; Recombinant Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
A short-lived nuclear phosphoprotein encoded by the human ets-2 proto-oncogene is stabilized by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cycloheximide; Diglycerides; Enzyme Activation; Gene Expression Regulation; Half-Life; Humans; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Processing, Post-Translational; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription Factors | 1988 |
Possible involvement of phosphorylation of a 36,000-dalton protein of rat basophilic leukemia (RBL-2H3) cell membranes in serotonin release.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Basophils; Calcimycin; Cell Membrane; Diglycerides; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Isoquinolines; Leukemia, Experimental; Molecular Weight; Phosphoproteins; Phosphorylation; Piperazines; Rats; Serotonin; Tetradecanoylphorbol Acetate | 1986 |
Inhibitors of IL-2 production and IL-2 receptor expression in human leukemic T-cell line, Jurkat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cyclosporins; Dose-Response Relationship, Drug; Humans; Interleukin-2; Isoquinolines; Leukemia, Lymphoid; Piperazines; Receptors, Immunologic; Receptors, Interleukin-2; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1986 |
Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Indomethacin; Isoquinolines; Kidney; Lysophosphatidylcholines; Molecular Weight; Phospholipid Ethers; Phosphorylation; Piperazines; Prostaglandins; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Stimulation by vasoactive intestinal polypeptide of catecholamine synthesis in isolated bovine adrenal chromaffin cells. Possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Animals; Calcium; Carbachol; Catecholamines; Cattle; Colforsin; Dihydroxyphenylalanine; In Vitro Techniques; Isoquinolines; Piperazines; Tetradecanoylphorbol Acetate; Tyrosine; Vasoactive Intestinal Peptide | 1987 |
Role of protein kinase C in luteinizing hormone-releasing hormone (LHRH)-stimulated progesterone production in rat granulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; In Vitro Techniques; Isoquinolines; Kinetics; Phorbol Esters; Piperazines; Progesterone; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1987 |
Phorbol ester stimulates calcium sequestration in saponized human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Alprostadil; Benzofurans; Biological Transport, Active; Blood Platelets; Calcimycin; Calcium; Calcium Radioisotopes; Chelating Agents; Fura-2; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
Thrombin and C-kinase activators potentiate calcium-stimulated arachidonic acid release in human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Diglycerides; Diterpenes; Drug Synergism; Humans; Isoquinolines; Phospholipids; Piperazines; Protein Kinase C; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles; Thrombin | 1987 |
Demonstration of calcium-dependent phospholipase A2 activity in membrane preparation of rabbit neutrophils. Absence of activation by fMet-Leu-Phe, phorbol 12-myristate 13-acetate and A-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Cell Membrane; Enzyme Activation; In Vitro Techniques; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Tetradecanoylphorbol Acetate | 1988 |
Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Cell Membrane; HLA-DR Antigens; Humans; Interferon-gamma; Isoquinolines; Kinetics; Macrophages; Piperazines; Protein Kinase C; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1988 |
Sphingosine inhibits thyrotropin-releasing hormone binding to pituitary cells by a mechanism independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Membrane; Isoquinolines; Kinetics; Piperazines; Pituitary Gland; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Thyrotropin-Releasing Hormone | 1988 |
Ethanol-induced phospholipase C activation is inhibited by phorbol esters in isolated hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoquinolines; Animals; Calcimycin; Diglycerides; Enzyme Activation; Ethanol; Fluorescent Dyes; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1988 |
Interferon-gamma and interleukin-1 alpha induce transient translocation of protein kinase C activity to membranes in a B lymphoid cell line. Evidence for a protein kinase C-independent pathway in lymphokine-induced cytoplasmic alkalinization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cell Line; Cell Membrane; Cytoplasm; Cytosol; Humans; Hydrogen-Ion Concentration; Interferon-gamma; Interleukin-1; Isoquinolines; Mice; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Enzyme Activation; Gallic Acid; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane B2 | 1988 |
Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Calcium; Carcinogens; Cytoplasm; In Vitro Techniques; Isoquinolines; Lyngbya Toxins; Macrophages; Male; N-Formylmethionine Leucyl-Phenylalanine; Peritoneal Cavity; Piperazines; Plant Extracts; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Thapsigargin | 1988 |
Tumor-promoting phorbol esters stimulate the proliferation of interleukin-3 dependent cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Cell Division; Cell Survival; Colony-Stimulating Factors; Enzyme Activation; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Interleukin-3; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1988 |
Protein kinase C activities with different characteristics, including substrate specificity, from two human HL-60 leukemia cell variants.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Lipids; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Role for protein kinase C in the modulation of glomerular PGE2 production by angiotensin II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Dinoprostone; Female; Isoquinolines; Kidney Glomerulus; Phorbol Esters; Phorbols; Piperazines; Prostaglandins E; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
Decline in c-myc mRNA expression but not the induction of c-fos mRNA expression is associated with differentiation of SH-SY5Y human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Line; Diglycerides; Gene Expression Regulation; Humans; Isoquinolines; Neuroblastoma; Oncogenes; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester-mediated desensitization of histamine H1 receptors on a cultured smooth muscle cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Enzyme Activation; Indoles; Isoquinolines; Muscle, Smooth; Piperazines; Protein Kinase C; Pyrilamine; Receptors, Histamine H1; Tetradecanoylphorbol Acetate | 1988 |
Phosphorylation of T cell membrane proteins by activators of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antigens, Differentiation, T-Lymphocyte; Concanavalin A; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Isoquinolines; Kinetics; Membrane Proteins; Phosphorylation; Piperazines; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1988 |
Inhibition of human natural killer cell activity by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine is an early but post-binding event.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibody-Dependent Cell Cytotoxicity; Binding, Competitive; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Humans; Immunosuppressive Agents; Interferon Type I; Interleukin-2; Isoquinolines; Killer Cells, Natural; Kinetics; Lymphocyte Activation; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1988 |
Mechanism of cellular effect of phorbol esters on action of arginine vasopressin and angiotensin II on rat vascular smooth muscle cells in culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Depression, Chemical; Ethers; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Ionomycin; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1988 |
Lipopolysaccharide-induced murine B cell proliferation: a role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; DNA; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1988 |
Phorbol myristate acetate induces IL-2 secretion by HUT 78 cells by a mechanism independent of protein kinase C translocation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Humans; Interleukin-2; Isoquinolines; Lymphoma; Piperazines; Protein Kinase C; T-Lymphocytes; Tetradecanoylphorbol Acetate; Translocation, Genetic; Tumor Cells, Cultured | 1988 |
Interleukin-3-stimulated haemopoietic stem cell proliferation. Evidence for activation of protein kinase C and Na+/H+ exchange without inositol lipid hydrolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; Enzyme Activation; Hematopoietic Stem Cells; Hydrogen-Ion Concentration; Inositol Phosphates; Interleukin-3; Isoquinolines; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine | 1988 |
Possible involvement of diacylglycerol-activated, Ca2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Colforsin; Enzyme Activation; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonamides; Tetradecanoylphorbol Acetate | 1988 |
The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Gene Expression Regulation; Insulin; Isoquinolines; Phosphoenolpyruvate Carboxykinase (GTP); Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1987 |
Modulation of the Ca2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Animals; Antibodies, Monoclonal; Calcium; Carcinoma; Cattle; Extracellular Space; Humans; Hyperparathyroidism, Secondary; Isoquinolines; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; Tetradecanoylphorbol Acetate | 1988 |
Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Enzyme Activation; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Piperazines; Potassium; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Vasoconstriction | 1988 |
Phorbol esters and calcium-mobilizing hormones increase membrane-associated protein kinase C activity in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Arginine Vasopressin; Cell Membrane; Cells, Cultured; Enzyme Activation; Epinephrine; Isoquinolines; Kinetics; Liver; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1988 |
Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Catalase; Cell Line; Chlorobenzoates; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Ethanolamine; Ethanolamines; Free Radicals; Humans; Isoquinolines; Leukemia, Experimental; Nuclear Proteins; Phosphatidylserines; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Puromycin; Subcellular Fractions; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1987 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine(H-7), a potent inhibitor of protein kinases, inhibits the differentiation of HL-60 cells induced by phorbol diester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Differentiation; Cell Division; Cell Line; Depression, Chemical; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Male; Phosphorylation; Piperazines; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
Possible involvement of protein kinase C in parathyroid hormone degradation by osteoblast-like rat osteosarcoma cell line UMR106.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Piperazines; Protein Kinase C; Rats; Sarcoma, Experimental; Sulfonamides; Tetradecanoylphorbol Acetate | 1987 |
Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cytosol; Diglycerides; Enzyme Activation; Glycerides; Humans; Isoquinolines; Kinetics; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen Consumption; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Subcellular distribution of protein kinase C in rat colonic epithelial cells with different proliferative activities.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Compartmentation; Cell Division; Colon; Deoxycholic Acid; Intestinal Mucosa; Isoquinolines; Piperazines; Protein Kinase C; Rats; Solubility; Subcellular Fractions; Tetradecanoylphorbol Acetate | 1987 |
Inhibition of induced acute lung edema by a novel protein kinase C inhibitor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Animals; Disease Models, Animal; Enzyme Activation; Isoquinolines; Lung; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase C; Pulmonary Edema; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate | 1987 |
Protein kinase C activity, protein phosphorylation and germinal vesicle breakdown in Spisula oocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bivalvia; Fertilization; Isoquinolines; Oocytes; Phorbol Esters; Phosphoproteins; Phosphorylation; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Vitamin A | 1987 |
Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Animals, Newborn; Enzyme Induction; Epidermis; In Vitro Techniques; Isoquinolines; Kinetics; Mice; Ornithine Decarboxylase; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1987 |
Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Choline; Chromatography, High Pressure Liquid; Diglycerides; Glioma; Glycerides; Hybrid Cells; Isoquinolines; Neuroblastoma; Phosphatidylcholines; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1987 |
Involvement of protein kinase C in the phosphorylation of 46 kDa proteins which are phosphorylated in parallel with activation of NADPH oxidase in intact guinea-pig polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Cell-Free System; Chlorpromazine; Enzyme Activation; Female; Guinea Pigs; Isoquinolines; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidylserines; Phosphorylation; Piperazines; Protein Kinase C; Proteins; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
An inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine(H-7) inhibits TPA-induced reduction of vincristine uptake from P388 murine leukemic cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Isoquinolines; Leukemia P388; Mice; Molecular Weight; Phorbol Esters; Phosphoproteins; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Vincristine | 1986 |
Differential effects of protein kinase C activators on carbamylcholine- and high K+-induced rises in intracellular free calcium concentration in cultured adrenal chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Glands; Animals; Calcium; Carbachol; Cattle; Chromaffin Granules; Chromaffin System; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Piperazines; Potassium; Potassium Chloride; Protein Kinase C; Tetradecanoylphorbol Acetate | 1986 |
Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blood Platelets; Calcium; Humans; Isoquinolines; Kinetics; Molecular Weight; Myosins; Peptide Fragments; Phospholipids; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinases; Serotonin; Tetradecanoylphorbol Acetate | 1984 |
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Calmodulin; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Tetradecanoylphorbol Acetate | 1984 |
EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cell Line, Transformed; Cinnamates; Dinoprostone; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; Isoquinolines; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1995 |
Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Decidua; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Interleukin-1; Isoquinolines; Piperazines; Pregnancy; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL-lpr/lpr mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Isoquinolines; Mice; Mice, Mutant Strains; Piperazines; Protein Kinase C; T-Lymphocyte Subsets; Tetradecanoylphorbol Acetate | 1995 |
The recombinant GABA transporter GAT1 is downregulated upon activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Carrier Proteins; Cell Line; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Isoquinolines; Kidney; Kinetics; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Phorbol Esters; Piperazines; Protein Kinase C; Rats; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Protein kinase regulation of tumor necrosis factor alpha stimulated collagenase and stromelysin message levels in chondrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cartilage, Articular; Cell Membrane; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Enzyme Induction; Gene Expression Regulation; Isoquinolines; Kinetics; Matrix Metalloproteinase 3; Metalloendopeptidases; Neoplasm Proteins; Piperazines; Protein Kinase C; Recombinant Proteins; RNA, Messenger; Swine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C-dependent phosphorylation of a ciliary membrane protein and inhibition of ciliary beating.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Annexins; Carbazoles; Cell Fractionation; Cilia; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Erythrocytes; Indoles; Isoquinolines; Membrane Proteins; Movement; Phosphorylation; Phosphoserine; Phosphotyrosine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Sheep; Tetradecanoylphorbol Acetate; Trachea; Tyrosine | 1993 |
Endotoxin-induced tissue factor in human monocytes is dependent upon protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Endotoxins; Enzyme Activation; Gene Expression Regulation; Humans; Isoquinolines; Monocytes; Naphthalenes; Naphthol AS D Esterase; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Polycyclic Compounds; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Thromboplastin | 1993 |
Involvement of protein kinase A and C in the production of interleukin-1 alpha-induced prostaglandin E2 from mouse osteoblast-like cell line, MC3T3-E1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dinoprostone; Humans; Indoles; Indomethacin; Interleukin-1; Isoquinolines; Kinetics; Mice; Osteoblasts; Piperazines; Protein Kinase C; Pyrroles; Recombinant Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alprostadil; Animals; Base Sequence; Calcimycin; Cell Line; Cycloheximide; Dexamethasone; Enzyme Induction; Iloprost; Isoenzymes; Isoquinolines; Mice; Molecular Sequence Data; Piperazines; Prostaglandin-Endoperoxide Synthases; Tetradecanoylphorbol Acetate | 1994 |
The role of protein kinase A and protein kinase C in prostanoid IP receptor desensitization in NG108-15 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Guanylyl Imidodiphosphate; Hybrid Cells; Iloprost; Isoquinolines; Mice; Piperazines; Protein Kinase C; Rats; Receptors, Prostaglandin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Evidence that protein kinase C activities involved in regulating neurite growth are localized to distal neurites.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antibodies; Benzophenanthridines; Calcium; Cells, Cultured; Isoquinolines; Naphthalenes; Nerve Growth Factors; Neurites; Phenanthridines; Phosphorylation; Piperazines; Polycyclic Compounds; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetradecanoylphorbol Acetate | 1994 |
Role of protein kinase C in mediating NGF effect on neuropeptide Y expression in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Binding Sites; Blotting, Northern; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Gene Expression; Isoquinolines; Kinetics; Molecular Sequence Data; Naphthalenes; Nerve Growth Factors; Neuropeptide Y; Oligodeoxyribonucleotides; PC12 Cells; Piperazines; Polycyclic Compounds; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Synergistic effects of parathyroid hormone and 1,25-dihydroxyvitamin D3 on proliferation and vitamin D receptor expression of rat growth cartilage cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcitriol; Cell Division; Cells, Cultured; Cyclic AMP; Cycloheximide; Dactinomycin; DNA; Drug Synergism; Growth Plate; Isoquinolines; Parathyroid Hormone; Peptide Fragments; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1994 |
Effects of cyclic AMP on expression of LFA-1, Mac-1, and VLA-4 and eosinophilic differentiation of a human leukemia cell line, EoL-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Bucladesine; Butyrates; Cell Differentiation; Cell Division; Cyclic AMP; Eosinophils; Fluorescent Antibody Technique; Granulocyte Colony-Stimulating Factor; Humans; Integrin beta1; Integrins; Isoquinolines; Leukemia; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biological Transport; Cell Line; Genistein; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoflavones; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Neutrophils; Piperazines; Protein Kinase Inhibitors; Putrescine; Spermidine; Spermine; Sulfonamides; Temperature; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Differential modulation by protein kinase C of progesterone-activated responses in human sperm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcium; Cell Membrane; Fluorescent Dyes; Fura-2; Gramicidin; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Male; Membrane Potentials; Piperazines; Progesterone; Protein Kinase C; Spermatozoa; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Contractile hyperreactivity and alteration of PKC activity in gastric fundus smooth muscle of diabetic rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium Channels; Cell Membrane; Diabetes Mellitus, Experimental; Gastric Fundus; In Vitro Techniques; Isoquinolines; Isradipine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperazines; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1994 |
Vasoactive intestinal polypeptide stimulates cyclic AMP production in mouse N1E-115 neuroblastoma cells: modulation by a protein kinase C activator and ionomycin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Calcium; Carcinogens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Enzyme Activation; Ionomycin; Isoquinolines; Kinetics; Mice; Neuroblastoma; Phorbol Esters; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1994 |
Overexpression of csk inhibits acid-induced activation of NHE-3.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzoquinones; Cell Line; Chickens; CSK Tyrosine-Protein Kinase; Gene Expression; Gene Expression Regulation; Hydrogen-Ion Concentration; Isoquinolines; Kidney; Kinetics; Lactams, Macrocyclic; Opossums; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Recombinant Proteins; Rifabutin; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; src-Family Kinases; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Real-time PET analysis of metastatic tumor cell trafficking in vivo and its relation to adhesion properties.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Computer Systems; Endothelium, Vascular; Female; Integrins; Isoquinolines; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplastic Cells, Circulating; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tomography, Emission-Computed | 1995 |
Biphasic effect of staurosporine on thymocyte apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Apoptosis; Bucladesine; Calcimycin; Carbazoles; Carcinogens; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Indole Alkaloids; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Piperazines; Protein Kinase Inhibitors; Radiation-Sensitizing Agents; Staurosporine; Tetradecanoylphorbol Acetate; Thymus Gland; Time Factors | 1995 |
Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Base Sequence; Benzoquinones; Blotting, Northern; Cells, Cultured; Deferoxamine; Endothelial Growth Factors; Endothelium, Vascular; Hemeproteins; Hypoxia; Isoquinolines; Lactams, Macrocyclic; Lymphokines; Molecular Sequence Data; Oxygen; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Sprague-Dawley; Rifabutin; Siderophores; Signal Transduction; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1995 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on estrogen receptor activity in MCF-7 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Female; Humans; Isoquinolines; Molecular Sequence Data; Piperazines; Protein Kinase C; Receptors, Estrogen; Receptors, Glucocorticoid; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Role of protein kinase C in mediating effects of hydrogen peroxide in guinea-pig ventricular myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Calcium; Cell Size; Enzyme Activation; Guinea Pigs; Heart Ventricles; Homeostasis; Hydrogen Peroxide; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardium; Phenanthridines; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Thromboxane A2-stimulated phospholipase D in osteoblast-like cells: possible involvement of PKC.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cell Line; Choline; DNA; Isoquinolines; Mice; Naphthalenes; Osteoblasts; Phospholipase D; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thromboxane A2 | 1995 |
Naphthalenesulphonamides block neutrophil superoxide production by intact cells and in a cell-free system: is myosin light chain kinase responsible for these effects?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Cell-Free System; Enzyme Inhibitors; Guinea Pigs; Humans; Isoquinolines; Myosin-Light-Chain Kinase; Naphthalenes; Neutrophils; Octoxynol; Piperazines; Sulfonamides; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acids; Animals; Anti-Bacterial Agents; Cell Membrane; Chlorocebus aethiops; Diphtheria Toxin; DNA; Endosomes; Enzyme Inhibitors; Epidermal Growth Factor; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Macrolides; Molecular Weight; Piperazines; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Staurosporine; Tetradecanoylphorbol Acetate; Vero Cells | 1995 |
Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Heme; Hemopexin; Hydrogen Peroxide; Isoquinolines; Kinetics; Liver Neoplasms; Metallothionein; Mice; Molecular Sequence Data; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Rabbits; Reactive Oxygen Species; RNA, Messenger; Sequence Deletion; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Xanthine; Xanthines | 1995 |
Dependence of endothelin-1 secretion on Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Biological Transport; Calcium; Cells, Cultured; Cyclic GMP; Endothelins; Endothelium, Vascular; Isoquinolines; Phenanthridines; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate | 1995 |
Signal requirements for production of luteinizing hormone releasing-hormone by human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Genistein; Gonadotropin-Releasing Hormone; Humans; Interleukin-2; Isoflavones; Isoquinolines; Lectins, C-Type; Male; Middle Aged; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1995 |
Effect of insulin on hydrogen peroxide production by human polymorphonuclear leukocytes. Studies with monoclonal anti-insulin receptor antibodies, and an agonist and an inhibitor of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibodies, Monoclonal; Female; Flow Cytometry; Fluoresceins; Humans; Hydrogen Peroxide; Insulin; Isoquinolines; Male; Neutrophils; Piperazines; Protein Kinase C; Receptor, Insulin; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate | 1995 |
Role of protein kinase C isozymes in Fc gamma receptor-mediated intracellular killing of Staphylococcus aureus by human monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Cross Reactions; Cross-Linking Reagents; Diglycerides; Humans; Isoenzymes; Isoquinolines; Molecular Sequence Data; Monocytes; Phagocytosis; Piperazines; Protein Kinase C; Reactive Oxygen Species; Receptors, IgG; Staphylococcus aureus; Staurosporine; Tetradecanoylphorbol Acetate; Translocation, Genetic; Type C Phospholipases | 1995 |
Interleukin-1 beta induction of tissue inhibitor of metalloproteinase (TIMP-1) is functionally antagonized by prostaglandin E2 in human synovial fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Bucladesine; Cells, Cultured; Colforsin; Collagenases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Glycoproteins; Humans; Immunoenzyme Techniques; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Messenger; Staurosporine; Synovial Membrane; Tetradecanoylphorbol Acetate; Thionucleotides; Tissue Inhibitor of Metalloproteinases; Up-Regulation | 1995 |
Modulation of human microglial cell superoxide production by cytokines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytes; Cells, Cultured; Cytokines; Humans; In Vitro Techniques; Isoquinolines; Microglia; Piperazines; Protein Kinase C; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
ACTH-induced c-myc proto-oncogene expression precedes antimitogenic effect during differentiation of fetal rat adrenocortical cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Base Sequence; Blotting, Northern; Cell Differentiation; Cell Division; Female; Gene Expression Regulation, Developmental; Genes, myc; Immunohistochemistry; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1995 |
Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C-independent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Calcimycin; Calcium; Calcium-Transporting ATPases; Cholera Toxin; Colforsin; Drug Synergism; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Hydroquinones; Isoquinolines; Leukemia-Lymphoma, Adult T-Cell; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Piperazines; Protein Kinase C; Receptors, Interleukin-2; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Staurosporine; T-Lymphocytes; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1995 |
Regulation of platelet-derived growth factor A and B chain gene expression in bone marrow stromal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cyclic AMP; Gene Expression; Isoquinolines; Mice; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-sis; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1995 |
The relaxant action of jatrophone in rat portal vein. A comparison with protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Caffeine; Calcium; Diterpenes; Endothelins; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Piperazines; Portal Vein; Potassium Chloride; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Vasodilation | 1995 |
The protein kinase C inhibitor H7 blocks phosphorylation of stathmin during TPA-induced growth inhibition of human pre-B leukemia REH6 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Burkitt Lymphoma; Calmodulin; Cell Cycle; Cell Division; Humans; Imidazoles; Isoquinolines; Microtubule Proteins; Phosphoproteins; Phosphorylation; Piperazines; Preleukemia; Protein Kinase C; Stathmin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Survival; Cell-Free System; Cytoplasmic Granules; Diglycerides; Dose-Response Relationship, Drug; Humans; Isoquinolines; Kinetics; Naphthalenes; Neutrophils; Phosphatidic Acids; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amphiregulin; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bryostatins; Culture Media, Conditioned; Cycloheximide; Dose-Response Relationship, Drug; EGF Family of Proteins; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Isoquinolines; Lactones; Macrolides; Piperazines; Polyunsaturated Alkamides; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein kinase C-and ras-dependent activation of c-jun gene by human papillomavirus type 11 E5a oncoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Genes, jun; Humans; In Vitro Techniques; Isoquinolines; Keratinocytes; Mice; Oncogene Proteins, Viral; Papillomaviridae; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 1995 |
Does ischemic preconditioning trigger translocation of protein kinase C in the canine model?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Coronary Circulation; Dogs; Hemodynamics; Isoquinolines; Microscopy, Fluorescence; Myocardial Ischemia; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1995 |
Phorbol ester stimulated cathepsin L expression in U937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cathepsin L; Cathepsins; Cell Differentiation; Cycloheximide; Cysteine Endopeptidases; Drug Interactions; Endopeptidases; Enzyme Induction; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Monocytes; Neoplasm Proteins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vanadates | 1995 |
Interferon-tau activates protein kinase C in Madin Darby bovine kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Antiviral Agents; Cattle; Cell Line; Enzyme Activation; Indoles; Interferon Type I; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Pregnancy Proteins; Protein Kinase C; Recombinant Proteins; Semliki forest virus; Sheep; Staurosporine; Tetradecanoylphorbol Acetate; Trophoblasts | 1995 |
Suppression of cytochrome P450 Cyp1a-1 induction in murine hepatoma 1c1c7 cells by 12-O-tetradecanoylphorbol-13-acetate and inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Isoquinolines; Liver Neoplasms, Experimental; Naphthalenes; Piperazines; Polycyclic Compounds; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Differential effects of putative protein kinase C inhibitors on contraction of rat aortic smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Aorta; Dose-Response Relationship, Drug; Isoquinolines; Male; Muscle, Smooth, Vascular; Naphthalenes; Phenylephrine; Phorbol 12,13-Dibutyrate; Piperazines; Polycyclic Compounds; Potassium Chloride; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasoconstriction | 1993 |
Role of protein kinase C in tumor necrosis factor induction of endothelial cell urokinase-type plasminogen activator.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Induction; Extracellular Matrix; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Naphthalenes; Oligodeoxyribonucleotides; Piperazines; Plasminogen Activator Inhibitor 1; Polycyclic Compounds; Protein Kinase C; RNA; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha; Umbilical Veins; Urokinase-Type Plasminogen Activator | 1993 |
A role for cholecystokinin-stimulated protein tyrosine phosphorylation in regulated secretion by the pancreatic acinar cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amylases; Animals; Cells, Cultured; Cholecystokinin; Genistein; Isoflavones; Isoquinolines; Kinetics; Male; Pancreas; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Sincalide; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Phorbol ester-induced modulation of cell surface antigens on U-937 cells in protein-free medium: effect of protein kinase and calmodulin inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Calmodulin; CD4 Antigens; Culture Media, Serum-Free; Down-Regulation; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Imidazoles; Isoquinolines; Lipopolysaccharide Receptors; Lymphoma, Large B-Cell, Diffuse; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 1993 |
Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cells, Cultured; Dendrites; Female; Hippocampus; Imidazoles; Indoles; Isoquinolines; Naphthalenes; Neurites; Piperazines; Polycyclic Compounds; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Pyramidal Tracts; Pyrroles; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
The cytoplasmic domain of P-selectin is phosphorylated on serine and threonine residues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Alprostadil; Amino Acid Sequence; Antigens, CD; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Molecular Sequence Data; Molecular Weight; Mutagenesis, Site-Directed; P-Selectin; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Phosphoserine; Phosphothreonine; Piperazines; Platelet Membrane Glycoproteins; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Umbilical Veins | 1993 |
Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute-Phase Proteins; Alkaloids; Carcinoma, Hepatocellular; Genistein; Humans; Interleukin-1; Interleukin-6; Isoflavones; Isoquinolines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Forskolin and phorbol myristate acetate inhibit intracellular Ca2+ mobilization induced by amitriptyline and bradykinin in rat frontocortical neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Amitriptyline; Animals; Bradykinin; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Frontal Lobe; Imipramine; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; Neurons; Piperazines; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1993 |
Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cell Division; Gene Expression; Genes, myc; Humans; Immunoblotting; Interleukin-7; Isoquinolines; Molecular Weight; Phosphoproteins; Phosphorylation; Phosphotyrosine; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tyrosine | 1993 |
Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Chenodeoxycholic Acid; Cytosol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Genes, MHC Class I; Histocompatibility Antigens Class I; Humans; Isoquinolines; Kinetics; Liver Neoplasms; Piperazines; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Amplifying effect of endothelin-1 on serotonin-induced vasoconstriction of human umbilical artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Calcium Chloride; Dose-Response Relationship, Drug; Drug Synergism; Endothelins; Enzyme Activation; Female; Humans; In Vitro Techniques; Isoquinolines; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Pregnancy; Protein Kinase C; Serotonin; Tetradecanoylphorbol Acetate; Umbilical Arteries; Vasoconstriction | 1995 |
Calcium and protein kinase C play an important role in Campylobacter jejuni-induced changes in Na+ and Cl- transport in rat ileum in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Calmodulin; Campylobacter Infections; Campylobacter jejuni; Chlorides; Cyclic AMP; Dantrolene; Diarrhea; Enzyme Activation; Ileum; In Vitro Techniques; Ion Transport; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Sodium; Tetradecanoylphorbol Acetate; Verapamil | 1995 |
The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoembryonic Antigen; Carrier Proteins; Cell Compartmentation; Cell Differentiation; Cell Polarity; Clone Cells; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Gene Expression Regulation; Glucose; Humans; Intestinal Mucosa; Intestines; Isoquinolines; Membrane Glycoproteins; Membrane Proteins; Methylglucosides; Monosaccharide Transport Proteins; Piperazines; Protein Kinase C; Sodium; Sodium-Glucose Transporter 1; Tetradecanoylphorbol Acetate | 1995 |
Nickel and skin irritants up-regulate tumor necrosis factor-alpha mRNA in keratinocytes by different but potentially synergistic mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Dermatitis, Allergic Contact; Dimethyl Sulfoxide; Drug Synergism; Gene Expression Regulation; Irritants; Isoquinolines; Keratinocytes; Mice; Mice, Inbred BALB C; Nickel; Piperazines; Protein Kinase C; RNA, Messenger; Sodium Dodecyl Sulfate; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1995 |
Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Base Sequence; Dactinomycin; Gene Expression Regulation, Leukemic; Humans; Interleukin-3; Isoquinolines; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Naphthalenes; Neoplasm Proteins; Piperazines; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Interleukin-3; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1995 |
The mitogenic action of recombinant basic FGF in Swiss 3T3 cells is independent of early diradylglycerol production and downregulatable protein kinase C activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Diglycerides; DNA Replication; Down-Regulation; Enzyme Activation; Fibroblast Growth Factor 2; Isoquinolines; Mice; Mitogens; Piperazines; Protein Kinase C; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1994 |
Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Aluminum; Animals; Biological Transport; Calcium; Clone Cells; Cytosol; Diacylglycerol Kinase; DNA; Dogs; Gadolinium; Growth Substances; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Isoquinolines; Kinetics; Membrane Proteins; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Neomycin; Osteoblasts; Phosphorus Radioisotopes; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Proteins; Receptors, Calcium-Sensing; Receptors, Cell Surface; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phorbol ester-induced M-current suppression in bull-frog sympathetic ganglion cells: insensitivity to kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Diglycerides; Ganglia, Sympathetic; Isoquinolines; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Phorbol Esters; Phorbols; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rana catesbeiana; Receptors, Muscarinic; Tetradecanoylphorbol Acetate | 1994 |
Mycoplasma stimulates HIV-1 expression from acutely- and dormantly-infected promonocyte/monoblastoid cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acholeplasma laidlawii; Cell Line; HIV Core Protein p24; HIV-1; Humans; Isoquinolines; Macrophages; Monocytes; Mycoplasma; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
Role of protein kinase C activation in synthesis of complement components C2 and factor B in interferon-gamma-stimulated human fibroblasts, glioblastoma cell line A172 and monocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzoquinones; Calcium; Cells, Cultured; Complement C2; Complement Factor B; Enzyme Activation; Fibroblasts; Genistein; Glioblastoma; Humans; Interferon gamma Receptor; Interferon-gamma; Isoflavones; Isoquinolines; Lactams, Macrocyclic; Monocytes; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Receptors, Interferon; Rifabutin; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Up-Regulation | 1995 |
Modulation of topoisomerase activities by tumor necrosis factor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytotoxicity Tests, Immunologic; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Enzyme Activation; Isoquinolines; L Cells; Mice; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Further analysis of the effect of Ca2+ on morphogenesis of HVJ (Sendai virus) in LLC-MK2 cells: effects on phosphorylated M protein associated with viral morphogenesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Glycoproteins; Haplorhini; Immunoblotting; Isoquinolines; Kidney; Morphogenesis; Parainfluenza Virus 1, Human; Phosphorylation; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Viral Matrix Proteins; Virus Replication | 1994 |
Suppression of interleukin-1 alpha production by protein kinase C activators in human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Alkaloids; Cells, Cultured; Endothelium, Vascular; Humans; Interleukin-1; Isoquinolines; Lipopolysaccharides; Lyngbya Toxins; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1995 |
Signal transduction in SF9 insect cells: endocytosis of recombinant CD4 after phorbol ester treatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, CD; Calmodulin; CD4 Antigens; Cell Line; Cell Membrane; Endocytosis; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Spodoptera; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transfection | 1995 |
Activation of protein kinase C inhibits ATP-induced [Ca2+]i elevation in rat osteoblastic cells: selective effects on P2Y and P2U signaling pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Animals; Calcium; Cells, Cultured; Enzyme Activation; In Vitro Techniques; Isoquinolines; Osteoblasts; Piperazines; Protein Kinase C; Rats; Receptors, Purinergic; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Apoptosis; Cell Cycle; Cell Line; Cycloheximide; DNA, Neoplasm; Endodeoxyribonucleases; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Isoquinolines; Kinetics; Leukemia, Promyelocytic, Acute; Lovastatin; Mevalonic Acid; Piperazines; Protein Kinase C; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1995 |
The role of protein kinase C in inducing Alzheimer's A68 protein expression in the culture of human neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Humans; Immunoblotting; Immunochemistry; Isoquinolines; Nerve Tissue Proteins; Neuroblastoma; Piperazines; Protein Kinase C; Sulfonamides; tau Proteins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Survival-promoting and protein kinase C-regulating roles of basic FGF for hippocampal neurons exposed to phorbol ester, glutamate and ischaemia-like conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Hippocampus; Isoquinolines; Molecular Sequence Data; Neurons; Piperazines; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1993 |
Characterization of signaling pathways to Na+/H+ exchanger activation with epidermal growth factor in hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Epidermal Growth Factor; Genistein; Hydrogen-Ion Concentration; Isoflavones; Isoquinolines; Liver; Male; Phenylephrine; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Focal adhesion-associated proteins p125FAK and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bradykinin; Calcium; Cell Adhesion Molecules; Chelating Agents; Cytoskeletal Proteins; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTPase-Activating Proteins; Isoquinolines; Mice; Paxillin; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; ras GTPase-Activating Proteins; Tetradecanoylphorbol Acetate; Tyrosine | 1994 |
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Imidodiphosphate; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Egtazic Acid; Electric Conductivity; Electric Stimulation; Heart; Isoenzymes; Isoproterenol; Isoquinolines; Kinetics; Membrane Potentials; Myocardium; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Thioridazine; Time Factors | 1994 |
Synergy between phorbol esters and retinoic acid in inducing protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Chlorpromazine; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Isoquinolines; Kinetics; Phosphorylation; Piperazines; Protein Binding; Protein Kinase C; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Tretinoin; Trifluoperazine; Tritium | 1994 |
Biochemical regulation of the three different states of the cholecystokinin (CCK) receptor in pancreatic acini.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzodiazepinones; Bombesin; Carbachol; Cholecystokinin; Devazepide; GTP-Binding Proteins; In Vitro Techniques; Isoquinolines; Pancreas; Phosphorylation; Piperazines; Rats; Receptors, Cholecystokinin; Secretin; Sincalide; Sodium Fluoride; Tetradecanoylphorbol Acetate | 1994 |
A calcium-dependent protein kinase is present in tetrahymena.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Isoquinolines; Molecular Weight; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Tetradecanoylphorbol Acetate; Tetrahymena | 1994 |
Entamoeba histolytica: PKC transduction pathway activation in the trophozoite-fibronectin interaction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Alkaloids; Animals; Cell Adhesion; Cytoskeletal Proteins; Cytoskeleton; Entamoeba histolytica; Enzyme Activation; Fibronectins; Isoquinolines; Phosphorylation; Piperazines; Protein Kinase C; Protozoan Proteins; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Protein kinases mediate basic fibroblast growth factor's stimulation of proliferation and c-fos induction in oligodendrocyte progenitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Biomarkers; Brain; Brain Stem; Cell Division; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Gene Expression; Genes, fos; Genistein; Immunohistochemistry; Isoflavones; Isoquinolines; Kinetics; Oligodendroglia; Piperazines; Protein Kinase C; Protein Kinases; Rats; Rats, Sprague-Dawley; Stem Cells; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 1994 |
An increase in p50/p65 NF-kB binding to the HIV-1 LTR is not sufficient to increase viral expression in the primary human astrocyte.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytes; Base Sequence; Cells, Cultured; Fetus; Gene Expression Regulation, Viral; HIV Long Terminal Repeat; HIV-1; Humans; Isoquinolines; Molecular Sequence Data; NF-kappa B; NF-kappa B p50 Subunit; Piperazines; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 1994 |
Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Carrier Proteins; Cell Differentiation; Cell Division; Cycloheximide; Dactinomycin; Enzyme Activation; gamma-Glutamyltransferase; Gene Expression; Glucose; Isoquinolines; Kidney; Kinetics; LLC-PK1 Cells; Membrane Glycoproteins; Membrane Proteins; Monosaccharide Transport Proteins; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Sodium; Sodium-Glucose Transporter 1; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1994 |
Inhibition of mitochondrial superoxide generation in rat alveolar macrophages by 12-O-tetradecanoylphorbol-13-acetate: potential role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acridines; Animals; Cytochrome c Group; Isoquinolines; Kinetics; Luminescent Measurements; Macrophages, Alveolar; Male; Mitochondria; NADP; Oxidation-Reduction; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1994 |
Role of myosin light-chain kinase and protein kinase C in pepsinogen secretion from guinea pig gastric chief cells in monolayer culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Calcium; Carbachol; Cells, Cultured; Colforsin; Gastric Mucosa; Guinea Pigs; Immunoenzyme Techniques; Ionomycin; Isoquinolines; Male; Microscopy, Electron; Myosin-Light-Chain Kinase; Pepsinogens; Piperazines; Protein Kinase C; Rabbits; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
A possible role of protein kinase C in augmenting H+ secretion by nonsteroidal anti-inflammatory drugs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bucladesine; Histamine; Ibuprofen; Isoquinolines; Male; Piperazines; Protein Kinase C; Protons; Rabbits; Rana catesbeiana; Tetradecanoylphorbol Acetate | 1994 |
Prostaglandin F2 alpha enhances tyrosine phosphorylation and DNA synthesis through phospholipase C-coupled receptor via Ca(2+)-dependent intracellular pathway in NIH-3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Calcium; Dinoprost; DNA; Ionomycin; Isoquinolines; Mice; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Receptors, Prostaglandin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Type C Phospholipases; Tyrosine | 1994 |
Elevation of intracellular Ca2+ concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Electrophysiology; Fura-2; In Vitro Techniques; Isoproterenol; Isoquinolines; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rabbits; Sinoatrial Node; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1994 |
Signal transduction pathway(s) involved in phorbol ester and autocrine induction of interleukin-1 alpha mRNA in murine keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; Genistein; Interleukin-1; Isoflavones; Isoquinolines; Keratinocytes; Mice; Mitogen-Activated Protein Kinase 1; NF-kappa B; Piperazines; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Phorbol myristate acetate stimulates osteoclast formation in 1 alpha,25-dihydroxyvitamin D3-primed mouse embryonic calvarial cells by a prostaglandin-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcitriol; Cell Differentiation; Dinoprostone; Drug Synergism; Embryo, Mammalian; In Vitro Techniques; Isoquinolines; Mice; Mice, Inbred ICR; Osteoclasts; Piperazines; Skull; Stem Cells; Tetradecanoylphorbol Acetate | 1994 |
Dependence of thymocyte apoptosis on protein kinase C and phospholipase A2.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcimycin; Concanavalin A; DNA; Enzyme Activation; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thymus Gland | 1994 |
Lymphocytes and promonocytes attach to the synthetic [Tyr5,12, Lys7]- polyphemusin II peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Antimicrobial Cationic Peptides; Cell Adhesion; Cell Line; HIV-1; Humans; Isoquinolines; Kinetics; Lymphocytes; Molecular Sequence Data; Monocytes; Peptides; Phorbol Esters; Piperazines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virus Replication | 1994 |
Protein kinase C signal transduction pathway in ACTH-induced growth effect of rat adrenocortical cells in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenocorticotropic Hormone; Alkaloids; Animals; Cell Division; Cells, Cultured; Corticosterone; Isoquinolines; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Staurosporine; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Platelet-activating factor induces airway mucin release via activation of protein kinase C: evidence for translocation of protein kinase C to membranes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cats; Cell Fractionation; Cell Membrane; Cells, Cultured; Centrifugation, Density Gradient; Enzyme Activation; Epithelium; Isoenzymes; Isoquinolines; Kinetics; Molecular Weight; Mucins; Piperazines; Platelet Activating Factor; Protein Kinase C; Sphingosine; Tetradecanoylphorbol Acetate; Trachea | 1994 |
Localization of protein kinase C in primary cultures of human keratinocytes in relation to cell contact proteins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cadherins; Cell Adhesion; Cell Communication; Cells, Cultured; Cytoskeletal Proteins; Enzyme Activation; Fluorescent Antibody Technique; Humans; Isoquinolines; Keratinocytes; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Vinculin | 1994 |
Resolution of major protein kinase substrates in neutrophil cytosol in response to DAG/PS and arachidonic acid stimulation and the selective action of various protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acids; Calcium; Cytosol; Diglycerides; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; In Vitro Techniques; Isoquinolines; Molecular Weight; Neutrophils; Phosphatidylserines; Phosphorylation; Piperazines; Protein Kinase C; Substrate Specificity; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C is involved in 24-hydroxylase gene expression induced by 1,25(OH)2D3 in rat intestinal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Calcitriol; Cell Line; Cytochrome P-450 Enzyme System; Enzyme Activation; Epithelium; Gene Expression; Intestines; Isoenzymes; Isoquinolines; Molecular Sequence Data; Piperazines; Protein Kinase C; Rats; Steroid Hydroxylases; Tetradecanoylphorbol Acetate; Vitamin D3 24-Hydroxylase | 1994 |
Evidence for posttranscriptional regulation of transgenic protein kinase C-alpha in T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies; Blotting, Northern; CD3 Complex; Cell Division; Cell Membrane; Gene Expression Regulation; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Piperazines; Protein Kinase C; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1994 |
Transduction of retinoic acid and gamma-interferon signal for intercellular adhesion molecule-1 expression on human tumor cell lines: evidence for the late-acting involvement of protein kinase C inactivation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cell Adhesion Molecules; Enzyme Activation; Glioma; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Neuroblastoma; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1993 |
Comparison of the effects of tumour necrosis factor alpha stimulation and phorbol ester treatment on the immunocytochemical staining of intercellular adhesion molecule 1 in human renal carcinoma cell cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Humans; Immunoenzyme Techniques; Intercellular Adhesion Molecule-1; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Production of a unique antibody specific for membrane ruffles and its use to characterize the behavior of two distinct types of ruffles.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Antigens, Surface; Calmodulin; Cell Membrane; Chick Embryo; Culture Media, Serum-Free; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoquinolines; Kinetics; Membrane Proteins; Molecular Weight; Nocodazole; Paclitaxel; Piperazines; Protein Kinase Inhibitors; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Does the protein kinase C pathway modulate sarcolemma damage and the release of cytosolic proteins in the rat heart?
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium; Cytosol; Enzyme Activation; Isoquinolines; Myocardium; Piperazines; Protein Kinase C; Proteins; Rats; Rats, Wistar; Sarcolemma; Tetradecanoylphorbol Acetate | 1993 |
Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bromodeoxyuridine; Cell Death; Cycloheximide; Isoquinolines; Leukemia, Lymphoid; Necrosis; Piperazines; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1993 |
Role of protein kinase C during interferon-gamma- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Antigens, CD; Calcimycin; Carcinoma, Renal Cell; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1; Interferon-gamma; Isoquinolines; Kidney Neoplasms; Piperazines; Protein Kinase C; Recombinant Proteins; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cyclic AMP; DNA; Enzyme Activation; Humans; Isoquinolines; Osteoblasts; Osteosarcoma; Parathyroid Hormone-Related Protein; Piperazines; Protein Kinase C; Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Abrogation of TNF-mediated cytotoxicity by space flight involves protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Death; Cell Line; Dose-Response Relationship, Drug; Fibroblasts; Humans; Isoquinolines; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Space Flight; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1994 |
Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Acetylcholine; Alkaloids; Animals; Enzyme Activation; Hippocampus; In Vitro Techniques; Isoquinolines; Male; Phorbol 12,13-Dibutyrate; Piperazines; Potassium; Protein Kinase C; Pyridazines; Rats; Rats, Wistar; Serotonin; Staurosporine; Synaptosomes; Tetradecanoylphorbol Acetate | 1994 |
1,25(OH)2-vitamin D3 signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcitriol; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Diglycerides; Enzyme Activation; Ethanol; In Vitro Techniques; Isoquinolines; Muscles; Neomycin; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Piperazines; Signal Transduction; Tetradecanoylphorbol Acetate | 1994 |
Interleukin-1 beta inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electrophysiology; GTP-Binding Proteins; Guanosine Diphosphate; Guinea Pigs; Hippocampus; Interleukin-1; Isoquinolines; Neurons; Pertussis Toxin; Piperazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Involvement of protein kinase C and protein tyrosine kinase pathways in tumor necrosis factor-alpha-induced clustering of ovarian theca-interstitial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstenedione; Animals; Benzophenanthridines; Benzylidene Compounds; Catechols; Cell Adhesion; Diglycerides; Enzyme Activation; Female; Hypophysectomy; Isoquinolines; Luteinizing Hormone; Nitriles; Phenanthridines; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Theca Cells; Tumor Necrosis Factor-alpha; Tyrphostins | 1993 |
A protein kinase C-dependent activity modulates retinoic acid-induced transcription.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Chlorocebus aethiops; DNA; Enzyme Induction; Humans; Indoles; Isoenzymes; Isoquinolines; Maleimides; Molecular Sequence Data; Phosphorylation; Piperazines; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tretinoin | 1993 |
The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Base Sequence; Carrier Proteins; Cell Hypoxia; Cells, Cultured; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Gene Expression Regulation; Heat-Shock Proteins; Humans; Isoquinolines; Molecular Chaperones; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxygen; Piperazines; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Protein kinase C is crucial for the stimulation of sodium-dependent phosphate transport by parathyroid hormone-related peptide in osteoblast-like cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Biological Transport; Bone Neoplasms; Calcimycin; Calcium; Cell Line; Colforsin; Cytosol; Humans; Isoquinolines; Kinetics; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Phosphates; Piperazines; Protein Kinase C; Proteins; Rats; Sodium; Tetradecanoylphorbol Acetate | 1994 |
Increase in cell responses and protein phosphorylation of neutrophils induced by synthetic diacylglycerols.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azides; Blood Proteins; Brain; Diglycerides; Guinea Pigs; Isoquinolines; Kinetics; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Rats; Sodium Azide; Structure-Activity Relationship; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Insulin-like growth factor-I-enhanced secretion is abolished in protein kinase C-deficient chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Medulla; Amino Acid Sequence; Analysis of Variance; Animals; Brain; Calcium; Catecholamines; Cattle; Cells, Cultured; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Molecular Sequence Data; Peptide Fragments; Phorbol Esters; Piperazines; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rats; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Protein kinase C and calcium distribution in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; Hypertension; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1993 |
Regulation of parathyroid hormone gene expression and peptide secretion in human parathyroid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenoma; Alkaloids; Base Sequence; Blotting, Northern; Calcium; Cell Division; Cycloheximide; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hyperparathyroidism; Isoquinolines; Molecular Sequence Data; Oligonucleotide Probes; Parathyroid Hormone; Parathyroid Neoplasms; Piperazines; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Neuropeptide Y enhances LHRH binding to rat gonadotrophs in primary culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calmodulin; Cells, Cultured; Colforsin; Cyclic AMP; Gonadotropin-Releasing Hormone; GTP-Binding Proteins; Isoquinolines; Male; Neuropeptide Y; Pertussis Toxin; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1994 |
Protein kinase C inhibitors enhance differentiation of rat adipocyte precursor cells in serum-free culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipose Tissue; Alkaloids; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Glycerolphosphate Dehydrogenase; Isoquinolines; Male; Piperazines; Protein Kinase C; Rats; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate | 1994 |
Interactions between protein kinase C and arachidonic acid in the gonadotropin response to salmon and chicken gonadotropin-releasing hormone-II in goldfish.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Cells, Cultured; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins; Isoquinolines; Lipoprotein Lipase; Masoprocol; Phospholipases A; Phospholipases A2; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1994 |
Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Alkaloids; Animals; Chickens; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Female; Granulosa Cells; Inositol Phosphates; Isoquinolines; Piperazines; Progesterone; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85 alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Platelets; Catechols; Enzyme Activation; Humans; Isoquinolines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin; Tyrphostins | 1994 |
L-glutamine and L-asparagine stimulate Na+ -H+ exchange in porcine jejunal enterocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acid-Base Equilibrium; Amiloride; Ammonium Chloride; Animals; Asparagine; Cell Line; Epithelium; Fluoresceins; Fluorescent Dyes; Glutamine; Hydrogen-Ion Concentration; Isoquinolines; Jejunum; Kinetics; Mannitol; Meglumine; Piperazines; Protein Kinase C; Sodium; Sodium-Hydrogen Exchangers; Swine; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
A stimulatory role of protein kinase C in feline tracheal submucosal gland secretion.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cats; Glycoconjugates; Glycoproteins; Isoquinolines; Methacholine Chloride; Mucous Membrane; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Sodium; Sodium Radioisotopes; Sphingosine; Tetradecanoylphorbol Acetate; Trachea; Tritium | 1993 |
Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Genistein; Humans; Isoflavones; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Respiratory Burst; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1993 |
Conventional protein kinase C isoforms are not essential for cellular proliferation of a T cell lymphoma line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Division; Cell Line; DNA, Neoplasm; Flow Cytometry; Humans; Isoenzymes; Isoquinolines; Kinetics; Lymphoma, T-Cell; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thymidine; Tritium; Tumor Cells, Cultured | 1993 |
Inhibition and down-regulation of protein kinase C in cultured atrial myocytes: effects on distribution of specific granules and secretion of atrial natriuretic peptide.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Atrial Natriuretic Factor; Cells, Cultured; Culture Media; Cycloheximide; Cytoplasmic Granules; Down-Regulation; Fluorescent Antibody Technique; Isoquinolines; Microscopy, Electron; Microtubules; Myocardium; Piperazines; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Differential modulation of TTX-sensitive and TTX-resistant Na+ channels in spinal cord astrocytes following activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Enzyme Activation; Isoquinolines; Mathematics; Membrane Potentials; Models, Neurological; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channels; Spinal Cord; Tetradecanoylphorbol Acetate; Tetrodotoxin | 1993 |
Reciprocal effects of the protein kinase C inhibitors staurosporine and H-7 on the regulation of glycogen synthase and phosphorylase in the primary culture of hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Glycogen; Glycogen Synthase; Isoquinolines; Liver; Male; Phosphorylases; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Vasopressins | 1993 |
Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Enzyme Activation; Free Radicals; Humans; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate | 1993 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on protein kinase C and inositol phosphate metabolism in primary cultures of rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Inositol Phosphates; Isoquinolines; Kinetics; Liver; Male; Phosphatidylinositols; Piperazines; Polychlorinated Dibenzodioxins; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Endogenous protein kinase-C activation in osteoblast-like cells modulates responsiveness to estrogen and estrogen receptor levels.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaline Phosphatase; Alkaloids; Animals; Blotting, Northern; Calcium; Cell Division; Enzyme Activation; Estradiol; Homeostasis; Isoquinolines; Kinetics; Osteoblasts; Osteosarcoma; Piperazines; Protein Kinase C; Receptors, Estrogen; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Met-enkephalin induced escape from dexamethasone immunosuppression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Dexamethasone; Enkephalin, Methionine; GTP-Binding Proteins; Humans; Immunosuppressive Agents; Isoquinolines; Neutrophils; Pertussis Toxin; Piperazines; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Mitogenic signaling mechanisms of human cementum-derived growth factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Cells, Cultured; Dental Cementum; DNA; Fibroblasts; Gene Expression; Genes, fos; Genes, jun; Growth Substances; Humans; Inositol Phosphates; Isoquinolines; Kinetics; Mitogens; Molecular Sequence Data; Pertussis Toxin; Piperazines; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1993 |
Involvement of protein kinase C in the interleukin 1 alpha-induced gene expression of matrix metalloproteinases and tissue inhibitor-1 of metalloproteinases (TIMP-1) in human uterine cervical fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Collagen; Dinoprostone; Down-Regulation; Extracellular Matrix; Female; Fibroblasts; Gene Expression Regulation; Glycoproteins; Guinea Pigs; Humans; Interleukin-1; Isoquinolines; Metalloendopeptidases; Piperazines; Protein Kinase C; Protein Precursors; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinases; Uterus | 1993 |
Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Blood; Culture Media; Isoquinolines; Mice; Neuroblastoma; Piperazines; Protein Kinase C; Sphingosine; Swine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
The role of cytosolic Ca2+, protein kinase C, and protein kinase A in hormonal stimulation of phospholipase D in rat hepatocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Ethers, Cyclic; Glycerophospholipids; Isoquinolines; Liver; Male; Okadaic Acid; Phosphatidic Acids; Phospholipase D; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasopressins | 1994 |
Regulatory effect of phorbol esters on sphingosine kinase in BALB/C 3T3 fibroblasts (variant A31): demonstration of cell type-specific response--a preliminary note.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alkaloids; Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Isoenzymes; Isoquinolines; Kinetics; Lysophospholipids; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Bradykinin; Cells, Cultured; Diglycerides; Down-Regulation; Ethers, Cyclic; Inositol Phosphates; Isoquinolines; Kinetics; Models, Biological; Muscle, Smooth, Vascular; Norepinephrine; Okadaic Acid; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Rabbits; Receptors, Adrenergic, alpha-1; RNA, Messenger; Tetradecanoylphorbol Acetate | 1994 |
Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amnion; Arachidonic Acid; Aspirin; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Female; Humans; Isoquinolines; Piperazines; Pregnancy; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blood Proteins; Cell Membrane; Cytosol; Enzyme Activation; Humans; Ionomycin; Isoquinolines; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphates; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Zymosan | 1994 |
Lipopolysaccharide alters suckling rat liver glycogenolysis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Cytarabine; Disease Models, Animal; Glycogen; Indomethacin; Isoquinolines; Kupffer Cells; Lipopolysaccharides; Liver; Piperazines; Rats; Rats, Sprague-Dawley; Shock, Septic; Tetradecanoylphorbol Acetate | 1993 |
Activation of the secretory pathway leads to a decrease in the intracellular amyloidogenic fragments generated from the amyloid protein precursor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amyloid beta-Protein Precursor; Animals; Cell Line; Glioma; Humans; Isoquinolines; Kinetics; Molecular Weight; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1993 |
Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Action Potentials; Alkaloids; Amiloride; Animals; Carbazoles; Dose-Response Relationship, Drug; Furosemide; Guinea Pigs; Indoles; Isometric Contraction; Isoquinolines; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Ovalbumin; Piperazines; Protein Kinase C; Respiratory Muscles; Staurosporine; Tetradecanoylphorbol Acetate; Trachea | 1993 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Activation of phospholipase D following perturbation of the human T lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Enzyme Activation; Feedback; Humans; Isoquinolines; Lymphocyte Activation; Muromonab-CD3; Neoplasm Proteins; Phospholipase D; Piperazines; Protein Kinase C; Receptor-CD3 Complex, Antigen, T-Cell; Signal Transduction; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
[Effects of protein kinase C activator and inhibitor on release of tumor necrosis factor from mouse peritoneal macrophages].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Female; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred ICR; Peritoneal Cavity; Piperazines; Propionibacterium acnes; Protein Kinase C; Quercetin; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1993 |
Inhibitors of Ca2+ channels, calmodulin and protein kinases prevent A23187 and other inductions of metallothionein mRNA in EC3 rat hepatoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Chloroadenosine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Gallic Acid; Isoquinolines; Liver Neoplasms, Experimental; Metallothionein; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Messenger; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil | 1993 |
Interferon-alpha (IFN alpha) induces a cytolytic mechanism in ovarian carcinoma cells through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Emetine; Female; Humans; Interferon alpha-2; Interferon-alpha; Isoquinolines; Ovarian Neoplasms; Piperazines; Protein Biosynthesis; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'-monophosphate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amnion; Animals; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; Drug Synergism; Female; Isoquinolines; Oxytocin; Piperazines; Pregnancy; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Receptors, Angiotensin; Receptors, Oxytocin; Tetradecanoylphorbol Acetate; Up-Regulation | 1993 |
Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Blotting, Northern; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Humans; Isoquinolines; Molecular Sequence Data; Piperazines; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Rats; RNA, Messenger; Simian virus 40; Tetradecanoylphorbol Acetate; Transfection | 1993 |
Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Blotting, Northern; Cytochrome b Group; Dexamethasone; Drug Synergism; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-8; Isoquinolines; NADPH Oxidases; Neutrophils; Piperazines; RNA, Messenger; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Growth arrest of the breast cancer cell line, T47D, by TNF alpha; cell cycle specificity and signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Division; DNA, Neoplasm; Ethers, Cyclic; Humans; Isoquinolines; Okadaic Acid; Piperazines; Protein Kinase C; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Sulfonamides; Tetradecanoylphorbol Acetate; Thymidine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Azepines; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Immunoblotting; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Kinetics; Male; Myosin-Light-Chain Kinase; Myosins; Phosphates; Phosphorus Radioisotopes; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Desensitization of acetylcholine induced inositol 1,4,5-trisphosphate formation in neuroblastoma SH-SY5Y cells following repetitive acetylcholine stimulations.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Alkaloids; Animals; Down-Regulation; Enzyme Activation; Humans; Inosine Triphosphate; Isoquinolines; Neuroblastoma; PC12 Cells; Phosphatidylinositols; Piperazines; Protein Kinase C; Second Messenger Systems; Signal Transduction; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Base Sequence; Cell Line; Cyclic AMP; Female; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Oligodeoxyribonucleotides; Piperazines; Protein Kinase C; Proto-Oncogene Proteins c-jun; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line, J774.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Base Sequence; Bucladesine; Cholera Toxin; Colforsin; Consensus Sequence; Cyclic AMP; Dinoprostone; Female; Gene Expression Regulation, Neoplastic; Isoquinolines; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Proteins; NF-kappa B; Phosphorylation; Piperazines; Protein Kinases; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factor RelB; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Role of protein kinase-C in the alpha 1-adrenoceptor-mediated responses of perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Biological Transport; Cell Membrane; Cytosol; Diglycerides; Enzyme Activation; Isoquinolines; Kinetics; Liver; Male; Perfusion; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Staurosporine; Tetradecanoylphorbol Acetate | 1993 |
Possible involvement of protein kinase C in gonadotropin-induced ovulation in the rat ovary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cells, Cultured; Female; Gonadotropins, Equine; Granulosa Cells; Isoquinolines; Luteinizing Hormone; Ovary; Ovulation; Phorbol 12,13-Dibutyrate; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator | 1993 |
Fibronectin-induced increase in mesangial cell prostaglandin release. Effect of hyperglycemia and PKC inhibition.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cell Membrane; Fibronectins; Glomerular Mesangium; Glucose; Heparin; Humans; In Vitro Techniques; Isoquinolines; Male; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1993 |
ras protein activity is essential for T-cell antigen receptor signal transduction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; DNA-Binding Proteins; Gene Expression; Genes, Dominant; Humans; Interleukin-2; Isoquinolines; Lymphocyte Activation; NFATC Transcription Factors; Nuclear Proteins; Piperazines; Protein Kinase C; Proto-Oncogene Proteins p21(ras); Receptors, Antigen, T-Cell, alpha-beta; RNA, Messenger; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured | 1993 |
Induction of the c-jun proto-oncogene by a protein kinase C-dependent mechanism during exposure of human epidermal keratinocytes to ethanol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Ethanol; Gene Expression; Humans; Isoquinolines; Keratinocytes; Piperazines; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Proto-Oncogenes; RNA, Messenger; Tetradecanoylphorbol Acetate | 1993 |
Endothelins release 51Cr from cultured human cerebromicrovascular endothelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cerebrovascular Circulation; Chromium Radioisotopes; Dexamethasone; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kinetics; L-Lactate Dehydrogenase; Microcirculation; Piperazines; Protein Kinase Inhibitors; Ryanodine; Tetradecanoylphorbol Acetate; Verapamil | 1993 |
Down-regulation of protein kinase C and kinase inhibitors dissociate short- and long-term enhancement produced by one-trial conditioning of Hermissenda.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brachyura; Conditioning, Classical; Down-Regulation; Isoquinolines; Neuronal Plasticity; Photic Stimulation; Photoreceptor Cells; Piperazines; Protein Kinase C; Serotonin; Sphingosine; Tetradecanoylphorbol Acetate | 1993 |
Signal-transduction mechanisms of ATP-stimulated phosphatidylcholine secretion in rat type II pneumocytes: interactions between ATP and other surfactant secretagogues.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Cells, Cultured; Drug Interactions; Ionomycin; Isoquinolines; L-Lactate Dehydrogenase; Lung; Male; Phosphatidylcholines; Piperazines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Terbutaline; Tetradecanoylphorbol Acetate; Xanthines | 1993 |
Enhancement of thyrotropin-stimulated iodide organification in porcine thyroid cells after protein kinase-C inhibition.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Cells, Cultured; Glyceryl Ethers; Iodides; Isoquinolines; Piperazines; Protein Kinase C; Staurosporine; Swine; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 1993 |
Adhesiveness and proliferation of epithelial cells are differentially modulated by activation and inhibition of protein kinase C in a substratum-dependent manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Cell Adhesion; Cell Division; Cells, Cultured; Enzyme Activation; Intracellular Membranes; Isoquinolines; Pigment Epithelium of Eye; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1993 |
Platelet derived growth factor-A chain gene expression in cultured mesangial cells: regulation by phorbol ester at the level of mRNA abundance, transcription and mRNA stability.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Cells, Cultured; Drug Stability; Gene Expression Regulation; Glomerular Mesangium; Half-Life; Humans; Isoquinolines; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1993 |
Extracellular ATP-induced regulation of epidermal growth factor signaling in cultured renal LLC-PK1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Cytosol; Epidermal Growth Factor; ErbB Receptors; Inositol 1,4,5-Trisphosphate; Isoquinolines; Kidney; Kinetics; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate | 1993 |
Characterization of [3H]staurosporine binding in protein kinase C-II purified from rat brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenine Nucleotides; Alkaloids; Animals; Brain; Calcium; Carbazoles; Guanine Nucleotides; Indole Alkaloids; Isoquinolines; Phorbol 12,13-Dibutyrate; Phosphatidylserines; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Zinc | 1993 |
Thrombin promotes aortic endothelial cell spreading and microfilament formation in nonconfluent monolayer cultures.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Aorta; Cell Division; Cell Membrane; Cell Movement; Cells, Cultured; Endothelium, Vascular; Isoquinolines; Neomycin; Phosphatidylinositols; Piperazines; Protein Kinase C; Signal Transduction; Swine; Tetradecanoylphorbol Acetate; Thrombin; Time Factors; Vinculin | 1993 |
Phorbol ester-dependent regulation of nuclear protein tyrosine phosphatase in situ.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Nucleus; Enzyme Inhibitors; Ethers, Cyclic; Immunoblotting; Isoquinolines; Lymphocytes; Molecular Weight; Nuclear Proteins; Okadaic Acid; Phosphorylation; Piperazines; Protein Kinase C; Protein Tyrosine Phosphatases; Spleen; Swine; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Ectoprotein kinase activities on non-differentiated and differentiated U-937 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Alkaloids; Calcium; Carcinogens; Cell Differentiation; Cyclic AMP; Enzyme Inhibitors; Humans; Isoquinolines; Lymphoma, Large B-Cell, Diffuse; Oligopeptides; Phosphorylation; Phosvitin; Piperazines; Protein Kinase C; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Thyroid hormones stabilize acetylcholinesterase mRNA in neuro-2A cells that overexpress the beta 1 thyroid receptor.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholinesterase; Animals; Cell Line; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Ethers, Cyclic; Humans; Isoquinolines; Kinetics; Mice; Naphthalenes; Neuroblastoma; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Thyroid Hormone; Recombinant Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Triiodothyronine; Tumor Cells, Cultured | 1995 |
Redistribution of fodrin in an in vitro wound healing model of the corneal epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Cornea; Cytoplasm; Egtazic Acid; Epithelial Cells; Epithelium; Isoquinolines; Membrane Proteins; Microfilament Proteins; Microscopy, Fluorescence; Naphthalenes; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Wound Healing | 1995 |
Protein kinase C inhibits human hair follicle growth and hair fibre production in organ culture.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Hair; Hair Follicle; Humans; Indoles; Isoquinolines; Maleimides; Organ Culture Techniques; Piperazines; Protein Biosynthesis; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1995 |
Activators of protein kinase C but not of phospholipase C modulate adenylate cyclase-responses of normal pig epidermis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine; Adenylyl Cyclases; Animals; Bradykinin; Cell Division; Cholera Toxin; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; Epinephrine; Histamine; Isoquinolines; Keratinocytes; Piperazines; Protein Kinase C; Swine; Tetradecanoylphorbol Acetate; Thrombin; Type C Phospholipases | 1995 |
Effects of cyclic adenosine monophosphate-dependent protein kinase and calcium-dependent protein kinase modulators on stimulated gastric acid secretion in the perfused rat stomach.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Administration, Oral; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gastric Acid; Histamine; Injections, Intravenous; Isoquinolines; Male; Naphthalenes; Pentagastrin; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate | 1995 |
Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Ketoprostaglandin F1 alpha; Amino Acid Sequence; Antibodies, Anticardiolipin; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Female; Humans; Immunoglobulin G; Isoquinolines; Lupus Coagulation Inhibitor; Male; Molecular Sequence Data; Piperazines; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1995 |
Effects of wortmannin on glucose uptake and protein kinase C activity in rat adipocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adipocytes; Androstadienes; Animals; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Isoenzymes; Isoquinolines; Male; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protein Kinase C; Rats; Rats, Wistar; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
Protein kinase C inhibitors enhance G-protein induced phospholipase A2 activation in intact human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aluminum Compounds; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Fluorides; GTP-Binding Proteins; Humans; Isoquinolines; Kinetics; Naphthalenes; Okadaic Acid; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Piperazines; Platelet Aggregation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thrombin | 1996 |
Structural and enzymatic aspects of rhodopsin phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Eye Proteins; G-Protein-Coupled Receptor Kinase 1; Insecta; Isoquinolines; Kinetics; Light; Mass Spectrometry; Mice; Palmitic Acid; Palmitic Acids; Peptide Fragments; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Protein Kinases; Recombinant Proteins; Rhodopsin; Rod Cell Outer Segment; Serine; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Differentiation; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression; HL-60 Cells; Humans; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Sphingosine; Staurosporine; Suppression, Genetic; Tetradecanoylphorbol Acetate | 1996 |
The role of protein kinase C in carbachol-induced and of cAMP-dependent protein kinase in isoproterenol-induced secretion in primary cultured guinea pig parotid acinar cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha-Amylases; Animals; Calcium; Carbachol; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Inhibitors; Exocytosis; Guinea Pigs; Immunoblotting; Isoproterenol; Isoquinolines; Male; Parotid Gland; Phorbol 12,13-Dibutyrate; Piperazines; Protein Binding; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Interleukin-11 mRNA stabilization in phorbol ester-stimulated primate bone marrow stromal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bone Marrow Cells; Cell Line; Cell Nucleus; Dactinomycin; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Interleukin-11; Isoflavones; Isoquinolines; Kinetics; Luciferases; Naphthalenes; Open Reading Frames; Piperazines; Primates; Protein Kinase C; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Stromal Cells; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Transfection | 1996 |
Regulation of epithelial Na+ permeability by protein kinase C is tissue specific.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Alkaloids; Amiloride; Animals; Benzophenanthridines; Biological Transport; Bufo marinus; Enzyme Inhibitors; Epithelium; In Vitro Techniques; Isoquinolines; Kinetics; Membrane Potentials; Organ Specificity; Phenanthridines; Piperazines; Protein Kinase C; Rana catesbeiana; Rana pipiens; Skin; Skin Physiological Phenomena; Sodium; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder | 1996 |
Antioxidants inhibit the enhancement of malignant cell transformation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Carcinogens; Cell Transformation, Neoplastic; Drug Interactions; Enzyme Inhibitors; Fibroblasts; Isoquinolines; Mannitol; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H; Piperazines; Polychlorinated Dibenzodioxins; Protein Kinase C; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Vitamin E | 1996 |
GH inhibition of lipogenesis and stimulation of lipolysis in sheep adipose tissue: involvement of protein serine phosphorylation and dephosphorylation and phospholipase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyl-CoA Carboxylase; Adipose Tissue; Alkaloids; Animals; Bridged-Ring Compounds; Culture Techniques; Ethers, Cyclic; Glycerol; Growth Hormone; Isoquinolines; Lipid Metabolism; Lipids; Lipolysis; Male; Norbornanes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Protein Kinase C; Sheep; Staurosporine; Stimulation, Chemical; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones; Type C Phospholipases | 1996 |
Phosphorylation/dephosphorylation steps are key events in the phytochrome-mediated enhancement of nitrate reductase mRNA levels and enzyme activity in maize.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Darkness; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation, Plant; Isoquinolines; Light; Nitrate Reductase; Nitrate Reductases; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Phytochrome; Piperazines; Protein Kinase C; RNA, Messenger; RNA, Plant; Signal Transduction; Tetradecanoylphorbol Acetate; Zea mays | 1996 |
Cultured retinal capillary pericytes die by apoptosis after an abrupt fluctuation from high to low glucose levels: a comparative study with retinal capillary endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Bucladesine; Calcimycin; Capillaries; Cattle; Cell Survival; Cells, Cultured; Coculture Techniques; DNA; Endothelium, Vascular; Enzyme Inhibitors; Glucose; Isoquinolines; Kinetics; Microscopy, Electron; Muscle, Smooth, Vascular; Niacinamide; Piperazines; Retinal Vessels; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Ion Channel Gating; Isoquinolines; Neuropeptide Y; Nifedipine; omega-Conotoxin GVIA; PC12 Cells; Peptides; Piperazines; Protein Kinase C; Protein Kinases; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Thionucleotides | 1996 |
Protein kinase C in intracellular pH regulation in alveolar type II cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acids; Amiloride; Animals; Bicarbonates; Buffers; Extracellular Space; Hydrogen-Ion Concentration; Intracellular Membranes; Male; Protein Kinase C; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Sodium; Tetradecanoylphorbol Acetate | 1996 |
PKC-independent inhibition of cardiac L-type Ca2+ channel current by phorbol esters.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Guinea Pigs; Myocardium; Potassium Channels; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Feedback regulation of Na channels in rat CCT. IV. Mediation by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Feedback; Female; Kidney Tubules, Collecting; Male; Ouabain; Patch-Clamp Techniques; Phorbols; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate; Up-Regulation | 1996 |
The involvement of PKC in N-cadherin-mediated adherens junction assembly in cultured cardiomyocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinin; Animals; Cadherins; Cell Adhesion; Cells, Cultured; Chick Embryo; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Intercellular Junctions; Isoquinolines; Myocardium; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1996 |
Estrogen induces the expression of c-fos and c-jun genes in fibroblasts derived from human uterine endometrium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Base Sequence; Endometrium; Estradiol; Female; Fibroblasts; Gene Expression; Genes, fos; Genes, jun; Humans; Isoquinolines; Kinetics; Molecular Sequence Data; Piperazines; Progesterone; Protein Kinase C; Tetradecanoylphorbol Acetate | 1995 |
Regulation of intracellular pH by phospholipase A2 and protein kinase C upon neutrophil adhesion to solid substrata.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Albumins; Arachidonic Acid; Cell Adhesion; Fibronectins; Humans; Hydrogen-Ion Concentration; Lysophosphatidylcholines; Neutrophils; Phospholipases A; Phospholipases A2; Protein Kinase C; Terpenes; Tetradecanoylphorbol Acetate | 1996 |
The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cell Differentiation; Creatine Kinase; Enzyme Inhibitors; Indoles; Isoquinolines; Maleimides; Muscle, Skeletal; Myogenin; Myosin Light Chains; Protein Kinase C; Rats; Rats, Wistar; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1996 |
Identification of urokinase-type plasminogen activator receptor in human endothelial cells and its modulation by phorbol myristate acetate.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Endothelium; Gene Expression Regulation; Humans; Iodine Radioisotopes; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tetradecanoylphorbol Acetate | 1995 |
Differential alterations of ethanolamine and choline phosphoglyceride metabolism by clofibrate and retinoic acid in human fibroblasts are not mediated by phorbol ester-sensitive protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Clofibrate; Enzyme Inhibitors; Ethanolamine; Ethanolamines; Fibroblasts; Humans; Hypolipidemic Agents; Isoquinolines; Phosphatidylcholines; Phospholipids; Protein Kinase C; Skin; Staurosporine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin | 1996 |
Fibrinogen promotes monocyte adhesion via a protein kinase C dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Albumins; Alkaloids; Cell Adhesion; Cells, Cultured; Fibrin; Fibrinogen; Humans; Isoquinolines; Monocytes; Piperazines; Protein Kinase C; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1996 |
Effects of a phorbol ester and isoquinoline sulfonamides on rabbit parietal cell function.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Aminopyrine; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Parietal Cells, Gastric; Protein Kinase C; Protein-Tyrosine Kinases; Rabbits; Tetradecanoylphorbol Acetate | 1996 |
Gamma interferon induced increases in intracellular cathepsin B activity in PMA primed THP-1 cells are blocked by inhibitors of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cathepsin B; Cytoplasm; Humans; Infant; Interferon-gamma; Leukemia, Monocytic, Acute; Phloretin; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
H7, an inhibitor of protein kinase C, prevents serum-induced phosphorylation of Raf and MAP kinase in neuroblastoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Physiological Phenomena; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Mice; Mitogen-Activated Protein Kinase 1; Neuroblastoma; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Production of C-type natriuretic peptide in human aortic endothelial cells induced by activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aorta; Base Sequence; Cells, Cultured; Diglycerides; Endothelium; Enzyme Activation; Enzyme Inhibitors; Humans; Natriuretic Peptide, C-Type; Protein Biosynthesis; Protein Kinase C; Proteins; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Animals, Newborn; Bucladesine; Calcitonin; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dentin; Enzyme Activation; Hematopoietic Stem Cells; Male; Mice; Mice, Inbred Strains; Osteoblasts; Phorbol 12,13-Dibutyrate; Protein Kinase C; Signal Transduction; Skull; Tetradecanoylphorbol Acetate; Thionucleotides | 1996 |
Phorbol ester, but not endotoxin, desensitizes mannan-induced glycogenolysis in the perfused rat liver.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aprotinin; Calcimycin; Colforsin; Enzyme Inhibitors; Escherichia coli; Leupeptins; Lipopolysaccharides; Liver; Liver Glycogen; Male; Mannans; Norepinephrine; Perfusion; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate | 1996 |
Molecular mechanisms underlying the regulation of proenkephalin gene expression in cultured spinal cord cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mollusk Venoms; Nimodipine; Protein Kinase C; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Signal Transduction; Spinal Cord; Tetradecanoylphorbol Acetate | 1996 |
Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Bucladesine; Calmodulin; Cytoplasmic Granules; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Exocytosis; Genistein; Humans; Isoflavones; Lysosomes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Vanadates | 1996 |
Protein kinase C plays a key role in the cross-talk between intracellular signalings via prostanoid receptors in a megakaryoblastic cell line, MEG-01s.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium; Cell Line; Cyclic AMP; Dinoprostone; Hematopoietic Stem Cells; Humans; Iloprost; Ionomycin; Megakaryocytes; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Receptors, Prostaglandin; Receptors, Thrombin; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1996 |
Natural killer and lectin-dependent cytotoxic activities of Kurloff cells: target cell selectivity, conjugate formation, and Ca++ dependency.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Cell Adhesion; Chelating Agents; Concanavalin A; Cytotoxicity, Immunologic; Enzyme Inhibitors; Esterases; Female; Guinea Pigs; Humans; Ionophores; Killer Cells, Natural; Magnesium; Mice; Microscopy, Electron, Scanning; Phytohemagglutinins; Protein Kinase C; Species Specificity; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium Channel Blockers; Diglycerides; Enzyme Inhibitors; Fatty Acids; Gallic Acid; Glycerides; Guinea Pigs; Male; Neutrophils; Phosphatidic Acids; Propranolol; Serum Albumin, Bovine; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Triglycerides | 1997 |
Fluorescence depolarization as an early measure of T lymphocyte stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Concanavalin A; Cytoplasm; Enzyme Inhibitors; Fluoresceins; Fluorescence Polarization; Humans; Lymphocyte Activation; Lymphocyte Count; Phosphatidylinositols; Phytohemagglutinins; Protein Kinase C; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors | 1997 |
Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies; Benzoquinones; Cell Differentiation; Cell Line; Humans; Lactams, Macrocyclic; Megakaryocytes; Molecular Sequence Data; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Quinones; Rabbits; Rifabutin; Signal Transduction; Tetradecanoylphorbol Acetate; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein | 1997 |
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Division; Cytotoxicity, Immunologic; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Mice; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Adenosine stimulation of DNA synthesis in human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins | 1997 |
Glucose-induced fibronectin expression in endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Western; Cells, Cultured; Endothelium, Vascular; Fibronectins; Gene Expression; Glucose; Humans; Isoenzymes; Kinetics; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Time Factors; Umbilical Veins | 1997 |
Differential regulation by protein kinase C isoforms of nitric oxide synthase induction in RAW 264.7 macrophages and rat aortic smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Muscle, Smooth, Vascular; Naphthalenes; Nitric Oxide Synthase; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1997 |
Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D- and protein kinase C-dependent pathways in murine mammary adenocarcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Butanol; Adenocarcinoma; Animals; Butanols; Epidermal Growth Factor; Female; Mammary Neoplasms, Experimental; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Signal Transduction; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator | 1997 |
Parathyroid hormone-related protein and human myometrial cells: action and regulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Chorionic Gonadotropin; Colforsin; Corticotropin-Releasing Hormone; Female; Gene Expression Regulation; Humans; Muscle Relaxation; Myometrium; Okadaic Acid; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Pregnancy; Proteins; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1997 |
Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Apoptosis; Diglycerides; Diterpenes; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia; Mice; Neoplasm Proteins; Phorbol Esters; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
The long terminal repeats of human immunodeficiency virus type-1 and human T-cell leukemia virus type-I are activated by 12-O-tetradecanoylphorbol-13-acetate through different pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Viral; HIV Long Terminal Repeat; HIV-1; Human T-lymphotropic virus 1; Humans; Jurkat Cells; Mutation; Protein Kinase C; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate | 1997 |
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Atrial Natriuretic Factor; Calcium Channel Blockers; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gallopamil; Glucose; GTP-Binding Proteins; Insulin; Insulin Secretion; Ionomycin; Ionophores; Islets of Langerhans; Pertussis Toxin; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Thionucleotides; Virulence Factors, Bordetella | 1997 |
Turning of nerve growth cones induced by the activation of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcium Channels; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Neurons; Phorbol 12,13-Dibutyrate; Protein Kinase C; Purinergic Antagonists; Spinal Cord; Tetradecanoylphorbol Acetate; Xenopus | 1997 |
Regulation of heparin-binding EGF-like growth factor expression by phorbol ester in a human hepatoma-derived cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinoma, Hepatocellular; Cycloheximide; Epidermal Growth Factor; Gene Expression Regulation; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Protein Kinase C; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Reorganization of the cortical actin cytoskeleton during maturation division in the Tubifex egg: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium; Cell Size; Chelating Agents; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Meiosis; Microinjections; Microscopy, Fluorescence; Oligochaeta; Oocytes; Protein Kinase C; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Calcium and protein kinase C play a significant role in response to Shigella toxin in rabbit ileum both in vivo and in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bacterial Toxins; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Electrolytes; Ileum; Indomethacin; Inositol Phosphates; Male; Neutralization Tests; Prostaglandins E; Protein Kinase C; Rabbits; Shiga Toxins; Tetradecanoylphorbol Acetate; Verapamil | 1997 |
IRF-1 expression in normal human epidermal keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Calcium; Cells, Cultured; Dactinomycin; DNA-Binding Proteins; Gene Expression Regulation; Humans; Interferon Regulatory Factor-1; Interferon-gamma; Keratinocytes; Phosphoproteins; RNA, Messenger; Tetradecanoylphorbol Acetate | 1997 |
ATP-activated basolateral Na+/H+ exchange in human normal and cystic fibrosis airway epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adolescent; Adult; Ammonium Chloride; Cell Membrane; Cell Polarity; Cells, Cultured; Child; Cystic Fibrosis; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Nasal Mucosa; Nigericin; Potassium Chloride; Reference Values; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate | 1997 |
Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Blotting, Northern; Bronchi; Carcinoma, Non-Small-Cell Lung; Cells, Cultured; DNA Probes; Enzyme Inhibitors; Extracellular Matrix; Fibronectins; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Protein Serine-Threonine Kinases; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1997 |
The role of protein kinase C activity in the killing of Chinese hamster ovary cells by ionizing radiation and photodynamic treatment.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Cycle; Cell Survival; CHO Cells; Cricetinae; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Photochemotherapy; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Induction of neutrophil chemotactic factor production by staurosporine in rat peritoneal neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Dose-Response Relationship, Drug; Growth Substances; Intercellular Signaling Peptides and Proteins; Male; Neutrophils; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C regulates macrophage tumor necrosis factor secretion: direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Drug Tolerance; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 1997 |
Involvement of different transduction pathways in NF-kappa B activation by several inducers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Antioxidants; Base Sequence; Binding Sites; Cell Line; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Kinetics; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Protein kinase C dependent and independent mechanisms controlling rat trophoblast cell DNA synthesis and differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Benzophenanthridines; Blotting, Northern; Blotting, Western; Cell Differentiation; Cholesterol Side-Chain Cleavage Enzyme; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Isoquinolines; Male; Phenanthridines; Pregnancy; Progesterone; Protein Kinase C; Rats; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Trophoblasts; Tumor Cells, Cultured | 1997 |
Stimulation of protein kinase C activity by tumor necrosis factor-alpha in bovine bronchial epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bronchi; Cattle; Cell Movement; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Fibronectins; Isoenzymes; Kinetics; Naphthalenes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Follicle-stimulating hormone regulation on its receptor messenger ribonucleic acid levels in cultured rat granulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Northern; Cyclic AMP-Dependent Protein Kinases; DNA Probes; Down-Regulation; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Indoles; Maleimides; Rats; Rats, Wistar; Receptors, FSH; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1997 |
A GPIb alpha-related protein is expressed by fresh human breast carcinoma tissue and is regulated by a PKC-sensitive mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Breast; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Enzyme Inhibitors; Female; Humans; Immunohistochemistry; Kinetics; Neoplasm Invasiveness; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Protein Kinase C; Reference Values; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Acetylcholine agonists stimulate mitogen-activated protein kinase in oligodendrocyte progenitors by muscarinic receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Atropine; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Cholinergic Agents; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Oligodendroglia; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Signal Transduction; Stem Cells; Tetradecanoylphorbol Acetate | 1997 |
Protein kinase C regulation of organic anion transport in renal proximal tubule.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Enzyme Inhibitors; Epithelial Cells; Fluorescein; Homeostasis; Kidney Tubules, Proximal; Killifishes; Models, Biological; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate | 1998 |
Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Angiotensin II; Animals; Antimetabolites; Carcinogens; Cells, Cultured; Cyclic AMP; Deoxyglucose; Diuretics, Osmotic; Enzyme Inhibitors; Estrenes; Gene Expression; Glucose; Growth Hormone; Kidney; Mannitol; Opossums; Phosphodiesterase Inhibitors; Phospholipases A; Pyrrolidinones; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Type C Phospholipases | 1998 |
The leukocyte common antigen (CD45) on human pre-B leukemia cells: variant glycoprotein form expression during the cell exposure to phorbol ester is blocked by a nonselective protein kinase inhibitor H7.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Leukocyte Common Antigens; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Stabilization and activation of p53 are regulated independently by different phosphorylation events.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Cell Line; Cell Nucleus; Doxorubicin; Enzyme Inhibitors; Humans; Indoles; Kinetics; Maleimides; Mice; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Kinase C; Recombinant Fusion Proteins; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53; Ultraviolet Rays | 1998 |
Effect of Ca2+/calmodulin-dependent protein kinase II inhibitors on the neurogenic cerebroarterial relaxation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Arteries; Coronary Vessels; Cyclic GMP; Dinoprost; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Norepinephrine; Oxytocics; Phosphorylation; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Tetrodotoxin; Vasoconstrictor Agents | 1997 |
Mycoplasma salivarium induces interleukin-6 and interleukin-8 in human gingival fibroblasts.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cattle; Cell Fractionation; Cell Line; Densitometry; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Genistein; Gingiva; Humans; Interleukin-6; Interleukin-8; Mice; Mycoplasma; Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate | 1997 |
Shigella dysenteriae type 1 toxin induced lipid peroxidation in enterocytes isolated from rabbit ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Bacterial Toxins; Calcimycin; Calcium Channel Blockers; Dantrolene; Dysentery, Bacillary; Enterotoxins; Enzyme Inhibitors; Ileum; In Vitro Techniques; Indomethacin; Ionophores; Lipid Peroxides; Male; Muscle Relaxants, Central; Rabbits; Reactive Oxygen Species; Shiga Toxins; Shigella dysenteriae; Tetradecanoylphorbol Acetate; Verapamil | 1998 |
Inhibitory effect of lead on tube formation by cultured human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Endothelium, Vascular; Extracellular Matrix; Humans; Laminin; Lead; Organometallic Compounds; Protein Kinase C; Proteoglycans; Tetradecanoylphorbol Acetate; Umbilical Cord | 1997 |
12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Neoplasm; Blast Crisis; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Half-Life; Humans; Ki-1 Antigen; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nucleic Acid Synthesis Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
TNF alpha induces a protein kinase C-dependent reduction in astroglial K+ conductance.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; Barium; Brain; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Membrane Potentials; Potassium Channels; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1998 |
Role of intracellular second messengers and reactive oxygen species in the pathophysiology of V. cholera O139 treated rabbit ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Calcimycin; Calcium; Calcium Channel Blockers; Cholera; Cyclic AMP; Dantrolene; Enzyme Activation; Ileum; Inositol Phosphates; Ionophores; Lipid Peroxidation; Protein Kinase C; Rabbits; Reactive Oxygen Species; Second Messenger Systems; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance | 1998 |
Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Antibodies, Monoclonal; Antigens, CD; Carcinogens; CD28 Antigens; CD3 Complex; Cell Division; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Indoles; Interleukin-2; Lymphocyte Activation; Maleimides; Protein Kinase C; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1998 |
Different effect of diastereoisomers of L-cystathionine sulfoxide on the stimulus coupled responses of human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Metabolism, Inborn Errors; Cystathionine; Enzyme Inhibitors; Genistein; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase Inhibitors; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C does not mediate phenylephrine-induced down-regulation of Madin-Darby canine kidney cell alpha-1B adrenoceptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; beta-Adrenergic Receptor Kinases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dogs; Down-Regulation; G-Protein-Coupled Receptor Kinase 3; Indomethacin; Phenylephrine; Prazosin; Protein Kinase C; Protein Serine-Threonine Kinases; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate | 1998 |
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1998 |
ZmcPKC70, a protein kinase C-type enzyme from maize. Biochemical characterization, regulation by phorbol 12-myristate 13-acetate and its possible involvement in nitrate reductase gene expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Chromatography, Gel; Diglycerides; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Histones; Hydrogen-Ion Concentration; Isoenzymes; Kinetics; Lipid Metabolism; Nitrate Reductase; Nitrate Reductases; Okadaic Acid; Phosphatidylserines; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Zea mays | 1998 |
Transforming growth factor-beta2 regulates C3 secretion in monocytes through a protein kinase C-dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Complement C3; Drug Interactions; Humans; Inflammation; Isoenzymes; Isoquinolines; Monocytes; Naphthalenes; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1998 |
Function and expression of CD44 during spreading, migration, and invasion of murine carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies, Monoclonal; Carcinogens; Cell Adhesion; Cell Division; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; Hyaluronan Receptors; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1998 |
Activation of purinergic P2Y2 receptors inhibits inducible NO synthase in cultured rat mesangial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Indoles; Interferon-gamma; Lipopolysaccharides; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1998 |
Effects of GnRH on protein kinase C activity, Ca2+ mobilization and steroidogenesis of human granulosa cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Enzyme Inhibitors; Estradiol; Female; Gonadotropin-Releasing Hormone; Granulosa Cells; Humans; Lipoxygenase Inhibitors; Masoprocol; Progesterone; Protein Kinase C; Steroids; Tetradecanoylphorbol Acetate | 1998 |
Up-regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in articular chondrocytes is mediated by serine/threonine and tyrosine kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cartilage, Articular; Cattle; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-3; Transcriptional Activation; Transforming Growth Factor beta; Up-Regulation | 1998 |
Inhibition of lung surfactant secretion by KN-62, a specific inhibitor of the calcium- and calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Male; Phosphatidylcholines; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Terbutaline; Tetradecanoylphorbol Acetate | 1998 |
Protein kinase C regulates Fas (CD95/APO-1) expression.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antibodies; Apoptosis; Biological Transport; Calcium; Enzyme Activation; fas Receptor; Humans; Hybridomas; Isoquinolines; Lymphocyte Activation; Mice; Protein Kinase C; Sulfonamides; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factors | 1998 |
Thrombin-induced reversal of astrocyte stellation is mediated by activation of protein kinase C beta-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Blotting, Western; Cells, Cultured; Enzyme Activation; Isoenzymes; Mice; Peptide Fragments; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin | 1998 |
Assessment of the mechanism by which prolactin stimulates progesterone production by early corpora lutea of pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carcinogens; Cells, Cultured; Corpus Luteum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Ionomycin; Ionophores; Lipoproteins, LDL; Luteal Phase; Phorbol 12,13-Dibutyrate; Progesterone; Prolactin; Protein Kinase C; Staurosporine; Stimulation, Chemical; Swine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1998 |
Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Aquaporin 4; Aquaporins; Astrocytes; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate | 1999 |
D-cystathionine ketimine and L-cystathionine ketimine enhance superoxide generation by human neutrophils in a different manner.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Arachidonic Acid; Benzoquinones; Cystathionine; Enzyme Inhibitors; Genistein; Humans; Lactams, Macrocyclic; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Serine; Staurosporine; Stereoisomerism; Superoxides; Tetradecanoylphorbol Acetate; Tyrosine | 1999 |
[Protein kinase C involved in the protecttve effect of anoxic preconditioning on vascular smooth muscle cells].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Cell Hypoxia; Cell Survival; Cells, Cultured; Ischemic Preconditioning; Male; Muscle, Smooth, Vascular; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1997 |
Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Alprostadil; Animals; Calcium Pyrophosphate; Carcinogens; Cartilage; Chondrocalcinosis; Chondrocytes; Cyclic AMP; Enzyme Inhibitors; Protein Kinase C; Signal Transduction; Swine; Tetradecanoylphorbol Acetate | 1999 |
The essential role of phorbol ester-sensitive protein kinase C isoforms in activation-induced cell death of Th1 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Indoles; Isoenzymes; Maleimides; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogens; Protein Kinase C; Tetradecanoylphorbol Acetate; Th1 Cells; Th2 Cells | 1999 |
Expression and characterization of protein kinase C in isolated rabbit parietal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminopyrine; Animals; Calcium; Cimetidine; Enzyme Inhibitors; Histamine; In Vitro Techniques; Isoenzymes; Male; Parietal Cells, Gastric; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protons; Rabbits; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Protein kinase C expression links natural antibody binding with surveillance of activated and preneoplastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites, Antibody; Cell Transformation, Neoplastic; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Genes, ras; Immunity, Innate; Isoenzymes; Male; Mice; Mice, Inbred C3H; Precancerous Conditions; Protein Kinase C; Protein Kinase C beta; Rats; Tetradecanoylphorbol Acetate; Tumor Stem Cell Assay | 1999 |
Protein kinase C-dependent anti-apoptotic mechanism that is associated with high sensitivity to anti-Fas antibody in ovarian cancer cell lines.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies; Apoptosis; Calcimycin; Cell Division; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Female; Flow Cytometry; Humans; Isoquinolines; Ovarian Neoplasms; Protein Kinase C; Signal Transduction; Sphingomyelin Phosphodiesterase; Sulfonamides; Tetradecanoylphorbol Acetate; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytosol; Female; Guinea Pigs; Marine Toxins; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rabbits; Superoxides; Tetradecanoylphorbol Acetate | 1999 |
A role of protein kinase C in the regulation of cytosolic phospholipase A(2) in bradykinin-induced PGI(2) synthesis by human vascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Base Sequence; Bradykinin; Calcium; Cells, Cultured; Cytosol; DNA Primers; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Kinetics; Maleimides; Mutagenesis, Site-Directed; Phospholipases A; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate | 1999 |
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hydrogen Peroxide; Immunohistochemistry; In Situ Nick-End Labeling; Muscle, Smooth, Vascular; Naphthalenes; Necrosis; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Reactive Oxygen Species; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Protein-kinase-C iso-enzymes support DNA synthesis and cell survival in colorectal-tumor cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Carcinogens; Cell Division; Cell Survival; DNA, Neoplasm; Enzyme Inhibitors; HT29 Cells; Humans; Isoenzymes; Membrane Proteins; Naphthalenes; Neoplasm Proteins; Oligonucleotides, Antisense; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
Phosphorylation of p40-phox during activation of neutrophil NADPH oxidase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Casein Kinase II; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Humans; Mitogens; Molecular Sequence Data; NADPH Oxidases; Neutrophils; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rabbits; Tetradecanoylphorbol Acetate | 1999 |
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; CD28 Antigens; Cell Adhesion Molecules; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intracellular Fluid; Ionophores; Jurkat Cells; Lymphocyte Activation; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic; Up-Regulation | 1999 |
The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Aged; Animals; Blotting, Western; Carbachol; Cattle; Cells, Cultured; Ciliary Body; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Isoenzymes; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Tetradecanoylphorbol Acetate; Trabecular Meshwork | 1999 |
Interleukin-1beta regulates CFTR expression in human intestinal T84 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenocarcinoma; Benzoquinones; Cell Line; Colon; Colonic Neoplasms; Cycloheximide; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Indoles; Interleukin-1; Lactams, Macrocyclic; Maleimides; Neoplasm Proteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Quinones; Rifabutin; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2000 |
Augmentation effects of high glucose on endotoxin-induced nitric oxide production in murine macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldehyde Reductase; Animals; Benzothiazoles; Cell Line; Drug Synergism; Enzyme Inhibitors; Glucose; Lipopolysaccharides; Macrophages; Mice; NAD; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phthalazines; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Thiazoles | 1999 |
Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bile Acids and Salts; Calcitriol; Cell Cycle; Cell Differentiation; Cell Division; Down-Regulation; Gene Expression Regulation; HL-60 Cells; Humans; Monocytes; Myeloblastin; Protein Kinase C; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Tretinoin | 2000 |
Effects of pentoxifylline and protein kinase C inhibitor on phorbol ester-induced intercellular adhesion molecule-1 expression in brain microvascular endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Capillaries; Cells, Cultured; Endothelium, Vascular; Female; Intercellular Adhesion Molecule-1; Male; Pentoxifylline; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Vasodilator Agents | 1999 |
Histamine H(3) receptors mediate inhibition of noradrenaline release from intestinal sympathetic nerves.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Calcium; Colforsin; Dose-Response Relationship, Drug; Ethylmaleimide; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Intestinal Mucosa; Intestines; Male; Muscle, Smooth; Myenteric Plexus; Nifedipine; Norepinephrine; omega-Conotoxins; Pertussis Toxin; Phenols; Receptors, Histamine H3; Rolipram; Sympathetic Nervous System; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetrodotoxin; Virulence Factors, Bordetella; Yohimbine | 2000 |
Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Androstadienes; Ceramides; DNA Probes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Hydrogen Peroxide; I-kappa B Proteins; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Organ Specificity; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 2000 |
Antithrombotic regulation in human endothelial cells by fibrinolytic factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Autocrine Communication; Blood Coagulation; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Endothelium, Vascular; Fibrin; Fibrinolysis; Gene Expression Regulation; Hot Temperature; Humans; Plasminogen Activator Inhibitor 1; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Umbilical Veins; Urokinase-Type Plasminogen Activator | 2000 |
Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Calcimycin; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cardiomegaly; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation; Heart; Ionomycin; Kinetics; Models, Cardiovascular; Myocardium; Myosin Heavy Chains; Promoter Regions, Genetic; Rats; Rats, Wistar; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Blotting, Northern; Choriocarcinoma; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Pregnancy; RNA, Messenger; Sphingosine; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uterine Neoplasms | 2000 |
Involvement of superoxide generated by polymorphonuclear leukocytes in endotoxin-induced uveitis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Disease; Animals; Blotting, Western; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Male; Neutrophil Activation; Neutrophils; Protein Kinase C; Rats; Rats, Inbred Lew; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Uveitis, Anterior | 2000 |
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine | 2000 |
Phosphorylation regulates spontaneous and evoked transmitter release at a giant terminal in the rat auditory brainstem.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Animals; Cochlear Nucleus; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; In Vitro Techniques; Indoles; Maleimides; Phorbol 12,13-Dibutyrate; Phosphorylation; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Wistar; Synaptic Transmission; Tetradecanoylphorbol Acetate | 2000 |
A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Antibodies, Monoclonal; Antibody Specificity; Calcium; Calmodulin; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Chelating Agents; Cycloheximide; Cytochalasin D; Edetic Acid; Endothelium, Vascular; Enzyme Inhibitors; Epitopes; Flow Cytometry; Genistein; HL-60 Cells; Humans; K562 Cells; Microtubules; Nocodazole; Protein Kinase C; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins | 2000 |
Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Indoles; Lactams; Lipopolysaccharides; Macrophages, Peritoneal; Male; Maleimides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2000 |
Extracellular Ca2+ sensitivity of mGluR1alpha induces an increase in the basal cAMP level by direct coupling with Gs protein in transfected CHO cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Cell Size; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Fluorescent Dyes; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Isoquinolines; MAP Kinase Signaling System; Protein Kinase C; Receptors, Metabotropic Glutamate; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection; Type C Phospholipases | 2000 |
Phorbor myristate acetate induces NADPH oxidase activity of cytochalasin B-primed neutrophils through the protein kinase C-independent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Androstadienes; Cytochalasin B; Ethanol; Granulocyte Colony-Stimulating Factor; Humans; Indoles; Maleimides; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phospholipase D; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2000 |
Enhancement of herpes simplex virus-induced polykaryocyte formation by 12-O-tetradecanoyl phorbol 13-acetate: association with the reorganization of actin filaments and cell motility.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Cell Fusion; Cell Movement; Cytochalasin D; Enzyme Inhibitors; Fluorescent Antibody Technique; Giant Cells; Herpesvirus 1, Human; Humans; Nocodazole; Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Viral Envelope Proteins; Virus Replication | 2000 |
Molecular cloning and functional characterization of Shaw-related potassium channels of trout CNS.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 4-Aminopyridine; Animals; Brain Chemistry; Carcinogens; Cloning, Molecular; DNA, Complementary; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Membrane Potentials; Molecular Sequence Data; Muscle Relaxants, Central; Oncorhynchus mykiss; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinine; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Shaw Potassium Channels; Species Specificity; Tetradecanoylphorbol Acetate; Tetraethylammonium | 2000 |
Antioxidants may contribute in the fight against ageing: an in vitro model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Antioxidants; Cell Line; Child; Child, Preschool; Disease Susceptibility; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Humans; Infant; Protein Kinase C; Quercetin; Tetradecanoylphorbol Acetate; Umbilical Veins; Vasculitis | 2000 |
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Binding Sites; Blotting, Northern; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Enzyme Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Liver Neoplasms; Luciferases; Models, Genetic; Mutation; Plasmids; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate; Thrombospondin 1; Time Factors; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Up-Regulation | 2001 |
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil | 2001 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carbazoles; Carcinogens; Cephaloridine; Cephalosporins; Cyclic AMP; Enzyme Inhibitors; Free Radicals; Gluconeogenesis; In Vitro Techniques; Indoles; Kidney Cortex; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; p-Aminohippuric Acid; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antigens, CD; Antigens, Differentiation; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoembryonic Antigen; Carcinogenicity Tests; Carcinoma; Cell Adhesion Molecules; Colonic Neoplasms; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naphthalenes; Point Mutation; Protein Kinase C; Serine; Staurosporine; Tetradecanoylphorbol Acetate; Thionucleotides; Tumor Cells, Cultured | 2001 |
Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Carbachol; Carcinogens; Cell Communication; Cells, Cultured; Cholinergic Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Acid; Interleukin-1; Parietal Cells, Gastric; Phenanthridines; Protein Kinase C; Rabbits; Sphingomyelin Phosphodiesterase; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Growth cone collapse through coincident loss of actin bundles and leading edge actin without actin depolymerization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Azepines; Biopolymers; Cell Size; Cells, Cultured; Culture Media, Conditioned; Cytochalasin D; Cytoskeleton; Ganglia, Invertebrate; Growth Cones; Microscopy, Video; Models, Biological; Mollusca; Myosin-Light-Chain Kinase; Naphthalenes; Polylysine; Protein Structure, Quaternary; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antigens, CD; Binding Sites; Carcinoma, Hepatocellular; Cell Line; Cytokine Receptor gp130; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Granulocyte Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-6; Liver Neoplasms; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Tetradecanoylphorbol Acetate; Trans-Activators; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Mice; Nuclear Proteins; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Tetradecanoylphorbol Acetate; Tumor Suppressor Protein p53; Ubiquitins | 2001 |
Effects of second messengers on gap junctional intercellular communication of ovine luteal cells throughout the estrous cycle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Bucladesine; Calcimycin; Calcium; Cells, Cultured; Chelating Agents; Culture Media, Conditioned; Cyclic AMP; Egtazic Acid; Enzyme Inhibitors; Estrous Cycle; Female; Fluorescent Antibody Technique; Gap Junctions; Immunohistochemistry; Ionophores; Luteal Cells; Progesterone; Protein Kinase C; Second Messenger Systems; Sheep; Tetradecanoylphorbol Acetate; Thionucleotides | 2001 |
[The effect of thrombin on tissue factor activity in cultured bovine aortic endothelial cells and its correlation with PKC pathway].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Cattle; Cells, Cultured; Endothelium, Vascular; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin; Thromboplastin | 1999 |
Induction of manganese superoxide dismutase by tumour necrosis factor-alpha in human endometrial stromal cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Embryo Implantation; Endometrium; Enzyme Inhibitors; Female; Humans; Middle Aged; Protein Kinase C; Protein Synthesis Inhibitors; Stromal Cells; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Effect of Leishmania donovani lipophosphoglycan on ornithine decarboxylase activity in macrophages.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anti-Bacterial Agents; Bucladesine; Calcimycin; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glycosphingolipids; Leishmania donovani; Leishmaniasis, Visceral; Lipopolysaccharides; Macrophages; Mice; Okadaic Acid; Ornithine Decarboxylase; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 2001 |
Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acid; Enzyme Inhibitors; Female; Goldfish; Gonadotropin-Releasing Hormone; Meiosis; Oocytes; Ovarian Follicle; Protein Kinase C; Receptors, LHRH; Testosterone; Tetradecanoylphorbol Acetate | 2002 |
Nucleo-cytoplasmic localization of influenza virus nucleoprotein depends on cell density and phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Count; Cell Line; Cell Nucleus; CHO Cells; Cricetinae; Cytoplasm; Enzyme Inhibitors; Humans; Influenza A virus; Nucleocapsid Proteins; Nucleoproteins; Phosphorylation; Protein Kinase Inhibitors; RNA-Binding Proteins; Tetradecanoylphorbol Acetate; Viral Core Proteins | 2002 |
Antigen-independent induction of histamine synthesis by immunoglobulin E in mouse bone marrow-derived mast cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens; Calcimycin; Calcium Signaling; Enzyme Inhibitors; Estrenes; Female; Histamine; Histidine Decarboxylase; Immunoglobulin E; In Vitro Techniques; Interleukin-3; Mast Cells; Mice; Mice, Inbred BALB C; Protein Kinase C; Pyrrolidinones; Receptors, IgE; RNA, Messenger; src-Family Kinases; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2002 |
Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Chlorodiphenyl (54% Chlorine); Diglycerides; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; HL-60 Cells; Humans; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Tetradecanoylphorbol Acetate | 2002 |
Regulation of CO production in cerebral microvessels of newborn pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminolevulinic Acid; Animals; Animals, Newborn; Calcium; Calcium Signaling; Capillaries; Carbon Monoxide; Catalysis; Cerebrovascular Circulation; Cytosol; Enzyme Inhibitors; Genistein; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Ionomycin; Ionophores; Phosphorylation; Photosensitizing Agents; Swine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 2003 |
Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Basilar Artery; Benzamides; Biological Transport; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Muscle, Smooth, Vascular; Oxyhemoglobins; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rabbits; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Tetradecanoylphorbol Acetate; Vasoconstriction | 2003 |
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antihypertensive Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinogens; Cells, Cultured; Colforsin; Corpus Striatum; Cyclic AMP; Drug Interactions; Embryo, Mammalian; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Humans; Isoquinolines; Neurons; Nifedipine; Protein Precursors; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetradecanoylphorbol Acetate; Transcriptional Activation; Transfection | 2003 |
Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Cell Differentiation; Cell Division; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Nonesterified; Intestines; Isoquinolines; Oleic Acid; Phosphorylation; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Triatoma; Trypanosoma cruzi | 2003 |
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes | 2003 |
Protein phosphorylation in neutrophils monitored with phosphospecific antibodies.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Antibodies; Binding Sites; Blood Proteins; Guinea Pigs; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
Oxidative and adhesive responses of human neutrophils to nitrovasodilators in vitro: the role of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Adhesion; Cells, Cultured; Enzyme Inhibitors; Genistein; Humans; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitric Oxide Donors; Nitroprusside; Oxidation-Reduction; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Respiratory Burst; Signal Transduction; Tetradecanoylphorbol Acetate; Vasodilator Agents | 2003 |
Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3-L1 Cells; Adipocytes; Animals; Benzylamines; Biphenyl Compounds; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Glycerol; Hydroxycholesterols; Indoles; Lignans; Lipolysis; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Naphthalenes; Oleic Acid; Phosphorylation; Protein Kinase C; Pyrroles; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vacuoles | 2004 |
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; I-kappa B Kinase; Indoles; Keratinocytes; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, PAR-2; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases | 2005 |
Role of protein kinase C in the monocyte-derived macrophage-mediated biodegradation of polycarbonate-based polyurethanes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Biocompatible Materials; Biotransformation; Cells, Cultured; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activators; Enzyme Inhibitors; Esterases; Hydrogen Peroxide; Macrophages; Monocytes; Oxidants; Peroxidases; Polycarboxylate Cement; Polyurethanes; Protein Kinase C; Respiratory Burst; Sodium Azide; Tetradecanoylphorbol Acetate | 2005 |
Role of kinases and G-proteins in the hyposmotic stimulation of cardiac IKs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cytochalasin D; Cytoskeleton; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoquinolines; KCNQ1 Potassium Channel; Maleimides; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Potassium Channels; Protein Kinase C; Protein-Tyrosine Kinases; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins | 2006 |
Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Anemia; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cisplatin; Enzyme Activation; Epithelial Cells; Erythropoietin; Humans; Kidney Neoplasms; Mitosis; Neoplasm Proteins; Protein Kinase C; Recombinant Proteins; Signal Transduction; Tetradecanoylphorbol Acetate | 2007 |
Protein kinase C is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in human bladder cancer cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Activators; Humans; Oxides; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Urinary Bladder Neoplasms | 2009 |
Follicle-stimulating hormone promotes proliferation of cultured chicken ovarian germ cells through protein kinases A and C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Follicle Stimulating Hormone; Isoquinolines; Ovum; Protein Kinase C; Receptors, FSH; Sulfonamides; Tetradecanoylphorbol Acetate | 2010 |
PKC plays a crucial roles in c-mpl gene expression in megakaryoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Carcinogens; Cell Division; Cells, Cultured; Humans; Megakaryocyte Progenitor Cells; Promoter Regions, Genetic; Protein Kinase C; Receptors, Thrombopoietin; Tetradecanoylphorbol Acetate | 2010 |
Oily fraction of Semecarpus anacardium Linn nuts involves protein kinase C activation for its pro-inflammatory response.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Carcinogens; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Macrophages, Peritoneal; Nitric Oxide Synthase Type II; Nuts; Plant Extracts; Protein Kinase C-delta; Quercetin; Rats; Semecarpus; Signal Transduction; Tetradecanoylphorbol Acetate | 2010 |
Involvement of subtypes γ and ε of protein kinase C in colon pain induced by formalin injection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Colonic Diseases; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Evoked Potentials; Formaldehyde; Gene Expression Regulation, Enzymologic; Male; Protein Kinase C; Protein Kinase C-epsilon; Rats; Rats, Wistar; Spinal Cord; Tetradecanoylphorbol Acetate; Time Factors; Visceral Pain | 2011 |
Suppressive effect of maslinic acid on PMA-induced protein kinase C in human B-lymphoblastoid cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Anticarcinogenic Agents; Benzopyrans; Cells, Cultured; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Oleanolic Acid; Precursor Cells, B-Lymphoid; Protein Kinase C; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid | 2012 |
The glucocorticoid dexamethasone inhibits U937 cell adhesion and neutrophil release via RhoA/ROCK1-dependent and independent pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Adhesion; Cells, Cultured; Dexamethasone; Female; Gene Expression; Glucocorticoids; Humans; Immunoblotting; Male; Neutrophils; Peroxidase; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; U937 Cells | 2014 |