tetracycline and zinc-nitrate

Cellulose xanthate-metal-tetracycline complexes (MCX-metal-Tc) were prepared and evaluated as a controlled release system for the antibiotics. Microcrystallized cellulose was chemically modified to cellulose xanthate (MCX). The amount of metal bound to MCX was 0.36 mmol Cu(II)/g MCX and 0.26 mmol Zn(II)/g MCX. Tetracycline (Tc) bound to MCX-metal chelates was 0.08 mmol/g MCX-Cu(II) and 0.04 mmol/g MCX-Zn(II). The Tc release from MCX-metal-Tc was greatly sustained compared with that from a mixture of cellulose/metal/Tc. Furthermore, MCX-metal-Tc manifested antibacterial activity that lasted for 7-22 days. These results suggest that MCX-metal-Tc is a polymeric antibacterial agent with prolonged antibacterial activity.

Topics: Anti-Bacterial Agents; Cellulose; Chemistry, Pharmaceutical; Copper; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Enterobacter aerogenes; Hydrogen-Ion Concentration; Nitrates; Solubility; Staphylococcus aureus; Tetracycline; Time Factors; Xanthines; Zinc Compounds