tetracycline has been researched along with juglone* in 1 studies
1 other study(ies) available for tetracycline and juglone
| Article | Year |
|---|---|
Use of juglone as antibacterial and potential efflux pump inhibitors in Staphylococcus aureus isolated from the oral cavity.
In this study the minimal inhibitory concentration (MICs) of tetracycline (Tet), erythromycin (Ery) and benzalkonium chloride (BC) in absence and in presence of a sub-MIC of juglone (Jug) were determined. In addition, the Ethidium bromide (EtBr) efflux assay was performed to assess the effect of Jug on EtBr cells accumulation. Our results showed a selective antimicrobial activity of Jug against the tested strains. A synergistic effect of Jug, drugs (Tet and Ery) and disinfectant (BC) was noticed with a reduction rate varied from 2 to 16-fold. In addition, the efflux of EtBr was inhibited depending on the Jug concentration. In the presence of Jug, a decrease in loss of EtBr from bacteria was observed. The concentration inducing 50 % of EtBr efflux inhibition after 15 min was about 182 μg ml Topics: Anti-Bacterial Agents; Benzalkonium Compounds; Biological Transport, Active; Child; Disinfectants; Drug Synergism; Enzyme Inhibitors; Erythromycin; Ethidium; Humans; Microbial Sensitivity Tests; Mouth; Naphthoquinones; Staphylococcus aureus; Tetracycline; Tunisia | 2016 |