tetracycline and ferrous-sulfate

Abnormalities of the gastrointestinal tract due to drug-induced injuries are common and often have important clinical consequences. Medications may cause damage by direct corrosive effects on mucosae or by alter processes, mucosal immunity, and local environmental conditions. The aim of this review is to guide practicing pathologists in the identification of drug-related injuries in gastrointestinal mucosal biopsies and resection specimens. Common causes of injury and their gross, endoscopic, and microscopic features are presented.

Topics: Alendronate; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Bone Density Conservation Agents; Cation Exchange Resins; Colchicine; Ferrous Compounds; Gastrointestinal Diseases; Gastrointestinal Tract; Gout Suppressants; Humans; Imidazoles; Immunosuppressive Agents; Mycophenolic Acid; Paclitaxel; Polystyrenes; Tetracycline; Tetrazoles

Serum concentrations of tetracycline hydrochloride and minocycline hydrochloride were compared when administered with water, milk, a meal, and 300 mg ferrous sulfate in two groups of eight volunteers. Absorption of both antibiotics was significantly decreased by administration with iron (77% inhibition with minocycline and 81% with tetracycline), milk (27% inhibition with minocycline, 65% with tetracycline), and food (13% inhibition with minocycline and 46% with tetracycline). The inhibitory effect on absorption with food and milk was significantly greater for tetracycline than for minocycline.

Topics: Animals; Delayed-Action Preparations; Ferrous Compounds; Food; Humans; Intestinal Absorption; Iron; Milk; Minocycline; Tetracycline; Tetracyclines; Time Factors

Topics: Acantholysis; Adolescent; Adult; Betamethasone; Colitis, Ulcerative; Female; Ferrous Compounds; Humans; Male; Stomatitis; Sulfasalazine; Tetracycline; Ulcer