tetracycline and ethyl-cellulose

The present study compared the effectiveness of two antimicrobials, tetracycline and metronidazole, in reducing subgingival microorganisms in periodontal pockets using an ethyl cellulose strip as the delivery medium. The study involved 30 patients, with a minimum of 3 periodontal pockets with probing depths > 6 mm throughout the oral cavity. Patients were given supragingival scaling and then divided into 5 groups, depending on the length of time the medication was in place. Sites were marked for tetracycline, metronidazole, and placebo. Sites were wiped and isolated, and baseline microbiology samples were taken for Gram staining and culture methods. After treatment, subgingival microbiological samples were taken again. The ethyl cellulose strips were removed and analyzed for any remaining drug. Results showed that tetracycline and metronidazole can both be applied locally to periodontal sites using ethyl cellulose strips and markedly suppress the subgingival bacteria over a period of several days. The tetracycline showed a faster release; however, the metronidazole required a lesser concentration to achieve complete reduction of the subgingival flora.

Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitrichomonal Agents; Cellulose; Colony Count, Microbial; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Hardness; Humans; Male; Metronidazole; Microbial Sensitivity Tests; Middle Aged; Periodontal Pocket; Tetracycline; Time Factors

Drug delivery systems (DDSs) based on micro-and nano- fibrous membrane have been developed for decades, in which great attention has been focused on achieving controlled drug release. However, the study on the integrated performance of these drug-loaded membranes in the use of in-vitro drug delivery dressing is lacking, as clinical medication also needs consideration from the perspectives of wound safety and patient convenience. Herein, a trilayered hierarchical porous ethyl cellulose (EC) fibrous membrane based DDS (EC-DDS) was developed by electro-centrifugal spinning. Significantly, the hierarchical porous structure of the EC-DDSs with high specific surface area (34.3 m

Topics: Anti-Bacterial Agents; Drug Delivery Systems; Humans; Porosity; Tetracycline

A conceptually novel periodontal drug delivery system (DDS) is described that is intended for treatment of microbial infections associated with periodontitis. The DDS is a composite wafer with surface layers possessing adhesive properties, while the bulk layer consists of antimicrobial agents, biodegradable polymers, and matrix polymers. The wafers contain poly(lactic-co-glycolic acid) as the main bioerodible component used in the bulk layer and ethyl cellulose applied as a matrix polymer enabling diffusion-controlled release. Starch and other polymers in combination with AgNO(3) serve as coatings adhesive to the teeth. In vitro experiments demonstrate that the wafers are capable of zero-order release of antimicrobial agents such as silver nitrate, benzylpenicillin, and tetracycline, for over 4 weeks.

Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cellulose; Cross-Linking Reagents; Drug Delivery Systems; Excipients; Gingiva; Lactic Acid; Microscopy, Electron, Scanning; Penicillin G; Penicillins; Periodontitis; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Silver Nitrate; Tetracycline

The release rate behavior of tetracycline (TC) from a sustained-release delivery system composed of an ethyl cellulose (EC) film and polyethyleneglycol (PEG) was studied using proton magnetic resonance (PMR) and UV spectroscopy. The optical density (OD) and spin-spin relaxation time (T2) were measured after the films were immersed in di-distilled water. The TC release rate was examined as a function of two variables: gradual changes in the relative amounts (% w/w) of the embedded TC and PEG. A high correlation was found between the fractional changes of T2 relaxation time and the percent release of TC, as measured by means of UV spectroscopy. The results revealed that the TC release profile from EC film is strongly dependent on the amount of embedded TC. On the other hand, the amount of embedded PEG markedly affected the release rate and release time of TC. These changes were reflected in a pronounced shortening of the T2 relaxation time. The improvement in the hydrophilic character of the EC polymer allowed better penetration and contact of water with the whole film matrix and enhanced the dissolution of TC.

Topics: Cellulose; Delayed-Action Preparations; Magnetic Resonance Spectroscopy; Polyethylene Glycols; Spectrophotometry, Ultraviolet; Tetracycline