tetracycline and acetohydroxamic-acid

The urease inhibitor acetohydroxamic acid (AHA) was assessed for its bacteriostatic and bactericidal effects on Helicobacter pylori. For eight isolates of H pylori, the minimum inhibitory concentration (MIC) was either 200 mg/l or 400 mg/l. Interactions between AHA and antimicrobial drugs used to treat H pylori were also determined. For most isolates AHA reduced the MIC for colloidal bismuth subcitrate (CBS), tetracycline, metronidazole, and amoxicillin. In a few isolates, however, AHA increased the minimum bactericidal concentration (MBC) for these antimicrobial treatments. In vitro AHA is active against H pylori and it interacts with other agents directed against H pylori.

Topics: Amoxicillin; Anti-Ulcer Agents; Drug Interactions; Helicobacter pylori; Humans; Hydroxamic Acids; In Vitro Techniques; Metronidazole; Microbial Sensitivity Tests; Organometallic Compounds; Tetracycline

Struvite bladder calculi were induced in rats with an intrarenal injection of urease-producing human T mycoplasma strain T960. Acetohydroxamic acid was effective in inhibiting calculous formation. Methylene blue, tetracycline, orthophosphate, diphosphonate, and hydrochlorothiazide had no inhibitory effect.

Topics: Animals; Diphosphonates; Hydrochlorothiazide; Hydroxamic Acids; Male; Methylene Blue; Mycoplasma; Phosphates; Rats; Tetracycline; Urinary Bladder Calculi