tetracycline and 4-acetylphenyloxooxazolidinylmethylacetamide

tetracycline has been researched along with 4-acetylphenyloxooxazolidinylmethylacetamide* in 1 studies

Other Studies

1 other study(ies) available for tetracycline and 4-acetylphenyloxooxazolidinylmethylacetamide

Article	Year
The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis. Biochemical and biophysical research communications, 1988, Feb-15, Volume: 150, Issue:3 Pulse labeling studies with Bacillus subtilis showed that DuP 721 inhibited protein synthesis. The IC50 of DuP 721 for protein synthesis was 0.25 micrograms/ml but it was greater than 32 micrograms/ml for RNA and DNA synthesis. In cell-free systems, DuP 721 concentrations up to 100 microM did not inhibit peptide chain elongation reactions under conditions where chloramphenicol, tetracycline and hygromycin B inhibited these reactions. Furthermore, Dup 721 did not cause phenotypic suppression of nonsense mutations suggesting that DuP 721 did not inhibit peptide chain termination. Thus, the mechanism of action of DuP 721 is at a target preceeding chain elongation. Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Chloramphenicol; DNA, Bacterial; Drug Resistance, Microbial; Hygromycin B; Microbial Sensitivity Tests; Mutation; Oxazoles; Oxazolidinones; Peptide Chain Elongation, Translational; RNA, Bacterial; Streptomycin; Tetracycline	1988

Article

Year

The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis.

Biochemical and biophysical research communications, 1988, Feb-15, Volume: 150, Issue:3

Pulse labeling studies with Bacillus subtilis showed that DuP 721 inhibited protein synthesis. The IC50 of DuP 721 for protein synthesis was 0.25 micrograms/ml but it was greater than 32 micrograms/ml for RNA and DNA synthesis. In cell-free systems, DuP 721 concentrations up to 100 microM did not inhibit peptide chain elongation reactions under conditions where chloramphenicol, tetracycline and hygromycin B inhibited these reactions. Furthermore, Dup 721 did not cause phenotypic suppression of nonsense mutations suggesting that DuP 721 did not inhibit peptide chain termination. Thus, the mechanism of action of DuP 721 is at a target preceeding chain elongation.

Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacterial Proteins; Chloramphenicol; DNA, Bacterial; Drug Resistance, Microbial; Hygromycin B; Microbial Sensitivity Tests; Mutation; Oxazoles; Oxazolidinones; Peptide Chain Elongation, Translational; RNA, Bacterial; Streptomycin; Tetracycline

1988