tetracycline has been researched along with 2-4-diaminopyrimidine* in 1 studies
1 other study(ies) available for tetracycline and 2-4-diaminopyrimidine
| Article | Year |
|---|---|
Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents.
Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39-0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus. Topics: Anti-Bacterial Agents; Carbazoles; Drug Design; Escherichia coli; Microbial Sensitivity Tests; Pyrimidines; Staphylococcus aureus; Structure-Activity Relationship | 2019 |