Page last updated: 2024-09-05

tesaglitazar and rosiglitazone

tesaglitazar has been researched along with rosiglitazone in 20 studies

Compound Research Comparison

Studies
(tesaglitazar)
Trials
(tesaglitazar)
Recent Studies (post-2010)
(tesaglitazar)
Studies
(rosiglitazone)
Trials
(rosiglitazone)
Recent Studies (post-2010) (rosiglitazone)
7413254,7495561,818

Protein Interaction Comparison

ProteinTaxonomytesaglitazar (IC50)rosiglitazone (IC50)
CDGSH iron-sulfur domain-containing protein 1Rattus norvegicus (Norway rat)1.1
Bile salt export pumpHomo sapiens (human)4.5853
Carbonic anhydrase 2Homo sapiens (human)4.069
Peroxisome proliferator-activated receptor alphaMus musculus (house mouse)0.08
Thromboxane-A synthase Homo sapiens (human)3.56
Amine oxidase [flavin-containing] BHomo sapiens (human)0.832
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)0.2481
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.038
ATP-binding cassette sub-family C member 8Homo sapiens (human)0.048
ATP-sensitive inward rectifier potassium channel 11Homo sapiens (human)0.048
Sodium/bile acid cotransporterHomo sapiens (human)5.1
CDGSH iron-sulfur domain-containing protein 2Homo sapiens (human)2.29
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)0.731

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (65.00)29.6817
2010's7 (35.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deussen, HJ; Ebdrup, S; Fleckner, J; Frost Jensen, A; Mortensen, SB; Nygaard, L; Pettersson, I; Pridal, L; Rasmussen, HB; Sauerberg, P1
Henke, BR1
Chung, HK; Dong Koo, K; Ho Woo, S; Hur, GC; Joo Yim, H; Kim, GT; Kim, KH; Kim, SH; Lee, CS; Oon Han, H; Sung Koh, J1
Chander, R; Chaturvedi, D; Ray, S; Srivastava, AK1
Audinot-Bouchez, V; Boutin, JA; Caignard, DH; Dacquet, C; Guillard, J; Hennuyer, N; Ktorza, A; Parmenon, C; Staels, B; Viaud-Massuard, MC2
Lombardo, F; Obach, RS; Waters, NJ1
Giri, S; Goel, A; Jain, M; Makadia, P; Patel, H; Patel, M; Patel, P; Pingali, H; Shah, S; Zaware, P1
Ahn, BN; Bae, MH; Chong, W; Han, T; Kim, E; Kim, EJ; Kim, JK; Kim, MK; Kim, SH; Lee, CH; Lim, JI; Moon, HS; Park, CS; Shim, HJ; Shin, CY; Shin, YA; Son, MH1
Basu, S; Giri, S; Godha, A; Goel, A; Goswami, A; Jain, M; Makadia, P; Patel, H; Patel, M; Patel, P; Patil, P; Pingali, H; Shah, S; Zaware, P1
Chae, YN; Chang, DJ; Jung, JW; Kang, HJ; Kim, MK; Kim, NJ; Koo, BW; Le, TV; Lee, KO; Li, F; Lim, JI; Moon, SH; Paek, SM; Park, HJ; Ryu, JS; Shin, CY; Shin, DH; Suh, YG1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Bahekar, R; Giri, S; Jain, M; Makadia, P; Patel, D; Patel, P; Pingali, H; Pola, S; Priyadarshini, P; Shah, M; Shah, SR; Suthar, D; Thube, B; Trivedi, C; Zaware, P1
Basu, S; Giri, S; Gite, A; Godha, A; Goswami, A; Jain, M; Patel, P; Pingali, H; Raval, P; Raval, S; Shah, M; Suthar, D1
Kagechika, K; Kubo, H; Shibata, Y; Usui, H; Yamaguchi, M1
Hashimoto, Y; Ishikawa, M; Makishima, M; Noguchi-Yachide, T; Okazaki, S; Shioi, R; Yamaguchi, T1
Amaudrut, J; Barth, M; Binet, J; Boubia, B; Broqua, P; Chatar, M; Dodey, P; Ferry, S; Gauthier, E; Guillier, F; Jacquier, E; Junien, JL; Lacombe, O; Legendre, C; Lepais, V; Llacer, J; Luccarini, JM; Masson, P; Montalbetti, C; Mounier, L; Peralba, P; Poupardin, O; Thourigny, A; Wettstein, G1
Kaya, T; Sheu, SH; Vajda, S; Waxman, DJ1
Claude, N; Guillouzo, A; Renaud, MP; Rogue, A; Spire, C1

Reviews

1 review(s) available for tesaglitazar and rosiglitazone

ArticleYear
Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.
    Journal of medicinal chemistry, 2004, Aug-12, Volume: 47, Issue:17

    Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Hypoglycemic Agents; Models, Molecular; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2004

Other Studies

19 other study(ies) available for tesaglitazar and rosiglitazone

ArticleYear
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: Binding Sites; Crystallography, X-Ray; Hypoglycemic Agents; Ligands; Models, Molecular; Oxazines; Phenylpropionates; Radioligand Assay; Receptors, Cytoplasmic and Nuclear; Stereoisomerism; Transcription Factors

2003
Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.
    Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4

    Topics: Animals; Area Under Curve; Biological Availability; Blood Glucose; Cell Line, Tumor; Drug Design; Humans; Hypoglycemic Agents; Indicators and Reagents; Lipids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Models, Molecular; Phenylpropionates; PPAR alpha; PPAR gamma; Rosiglitazone; Structure-Activity Relationship; Thiazolidinediones; Triglycerides

2007
Omega-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents.
    Bioorganic & medicinal chemistry, 2008, Mar-01, Volume: 16, Issue:5

    Topics: Alkanes; Alkylation; Amination; Animals; Hypoglycemic Agents; Hypolipidemic Agents; Lipid Metabolism; Male; Molecular Structure; Naphthalenes; PPAR gamma; Rats; Structure-Activity Relationship

2008
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.
    Bioorganic & medicinal chemistry letters, 2008, Mar-01, Volume: 18, Issue:5

    Topics: Hypoglycemic Agents; Molecular Structure; PPAR alpha; PPAR gamma; Quinolines; Structure-Activity Relationship

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15

    Topics: Animals; Carboxylic Acids; Diabetes Mellitus; Drug Design; Hypoglycemic Agents; Mice; Mice, Inbred NOD; Molecular Structure; Oxazoles; PPAR alpha; PPAR gamma; Rats; Rats, Zucker; Structure-Activity Relationship

2008
Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARalpha/gamma dual agonists.
    Bioorganic & medicinal chemistry letters, 2008, Sep-15, Volume: 18, Issue:18

    Topics: Animals; Combinatorial Chemistry Techniques; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Design; Mice; Molecular Structure; PPAR alpha; PPAR gamma; Pyridines; Rats; Rats, Sprague-Dawley

2008
Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
    Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20

    Topics: Animals; Carboxylic Acids; Diabetes Mellitus, Type 2; Dioxanes; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipids; Mesylates; Mice; Models, Chemical; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR gamma; Rats; Rats, Wistar; Transcriptional Activation

2008
Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Journal of medicinal chemistry, 2008, Oct-23, Volume: 51, Issue:20

    Topics: Animals; Cell Line; Drug Design; Humans; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Phenylpropionates; PPAR alpha; PPAR gamma; Stereoisomerism; Structure-Activity Relationship; Transcriptional Activation

2008
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
    Bioorganic & medicinal chemistry letters, 2009, May-15, Volume: 19, Issue:10

    Topics: Animals; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Mice; Oximes; PPAR alpha; PPAR gamma; Quinolines; Rats; Structure-Activity Relationship

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
    Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2

    Topics: Animals; Cricetinae; Disease Models, Animal; Ether; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Obese; Oximes; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship; Thiazoles

2011
Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
    Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10

    Topics: Administration, Oral; Animals; Cell Line; Dose-Response Relationship, Drug; Hypoglycemic Agents; Inhibitory Concentration 50; Mice; Molecular Structure; Oxazoles; Phenylpropionates; PPAR alpha; PPAR gamma; Protein Binding; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones; Thiophenes

2011
Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).
    Bioorganic & medicinal chemistry letters, 2012, Dec-01, Volume: 22, Issue:23

    Topics: Animals; Blood Glucose; Drug Design; Mice; PPAR alpha; PPAR gamma; Structure-Activity Relationship; Thiazolidinediones; Triglycerides; Weight Gain

2012
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
    Bioorganic & medicinal chemistry letters, 2017, 07-15, Volume: 27, Issue:14

    Topics: Acetamides; Binding Sites; Genes, Reporter; HEK293 Cells; Humans; Ligands; PPAR alpha; PPAR delta; Protein Binding; Stereoisomerism; Thiazolidinediones

2017
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
    Journal of medicinal chemistry, 2018, 03-22, Volume: 61, Issue:6

    Topics: Animals; Benzothiazoles; Carbon Tetrachloride Poisoning; Cell Line; Drug Discovery; Fibrosis; Hepatocytes; High-Throughput Screening Assays; Humans; Hypoglycemic Agents; Indoles; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides

2018
Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping.
    Biochemistry, 2005, Feb-01, Volume: 44, Issue:4

    Topics: Alkanesulfonates; Binding Sites; Cinnamates; Computational Biology; Humans; Ligands; Oxazines; Oxazoles; Phenylpropionates; PPAR gamma; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Structure, Tertiary; Rosiglitazone; Solvents; Thiazoles; Thiazolidinediones; Thiazolidines; Tyrosine

2005
Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes.
    Toxicology and applied pharmacology, 2011, Jul-01, Volume: 254, Issue:1

    Topics: Alkanesulfonates; Animals; Chromans; Gene Expression Profiling; Genes; Glycine; Hepatocytes; Humans; Male; Oligonucleotide Array Sequence Analysis; Oxazoles; Phenylpropionates; PPAR alpha; PPAR gamma; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Rosiglitazone; Thiazolidinediones; Troglitazone

2011