tert-butylbicyclophosphorothionate has been researched along with picrotoxin in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (45.45) | 18.7374 |
| 1990's | 23 (41.82) | 18.2507 |
| 2000's | 6 (10.91) | 29.6817 |
| 2010's | 1 (1.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miledi, R; Polenzani, L; Woodward, RM | 1 |
| Bloomquist, JR; Grubs, RE; Knipple, DC; Soderlund, DM | 1 |
| McIntyre, T; Skolnick, P | 1 |
| Biggio, G; Corda, MG; Giorgi, O; Longoni, B; Orlandi, M | 1 |
| Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, G; Serra, M | 1 |
| Demirgören, S; London, ED; Majewska, MD | 1 |
| Gee, KW; Lawrence, LJ; Yamamura, HI | 1 |
| Ho, IK; Ito, Y; Lim, DK; Nabeshima, T | 1 |
| Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P | 1 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Robinson, TN; Stirling, JM | 1 |
| Moguilewsky, M; Philibert, D; Shu, C; Vincens, M | 1 |
| Blednov, IuA; Gordeĭ, ML; Seredenin, SB | 1 |
| Ticku, MK | 1 |
| Seifert, J | 1 |
| Hamon, M | 1 |
| Miller, T; Olsen, RW; Szamraj, O | 1 |
| Bloomquist, JR; Soderlund, DM | 1 |
| Culp, S; Liljequist, S; Tabakoff, B | 1 |
| Majewska, MD; Schwartz, RD | 1 |
| Eldefrawi, AT; Eldefrawi, ME; Gant, DB | 1 |
| Crabbe, JC; Feller, DJ; Harris, RA | 1 |
| Barnes, EM; Clancey, CJ; Tehrani, MH | 1 |
| Gallo, V; Guidotti, A; Vaccarino, F; Wise, BC | 1 |
| Casida, JE; Lawrence, LJ | 2 |
| Gee, KW; Wamsley, JK; Yamamura, HI | 1 |
| Bymaster, FP; Squires, RF; Threlkeld, PG; Wong, DT | 1 |
| Ramanjaneyulu, R; Ticku, MK | 3 |
| Burke, TR; Rice, KC; Skolnick, P; Weissman, BA | 1 |
| Carter, DB; Dillon, GH; Hamilton, BJ; Im, WB; Pregenzer, JF | 1 |
| Carter, DB; Dillon, GH; Im, WB; McKinley, DD | 1 |
| Imaizumi, M; Machida, H; Miyazaki, S | 1 |
| Basile, AS; Drugan, RC; Ferland, RJ; Ha, JH | 1 |
| Chen, DZ; Chen, SH; Katsura, M; Kuriyama, K; Ohkuma, S | 1 |
| Samochocki, M; Strosznajder, J | 1 |
| Belelli, D; Chen, R; Lambert, JJ; Lan, NC; Peters, JA; Reyes, A | 1 |
| Ho, IK; Ito, Y | 1 |
| Marco Igual, M | 1 |
| Korpi, ER; Seeburg, PH | 1 |
| Dartois, E; Fillion, G; Haour, F; Marquette, C; Moyse, E; Popelier, M; Vincens, M | 1 |
| Cross, AJ; Green, AR; Misra, A; Murray, TK; Snape, MF | 1 |
| Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M | 1 |
| Sousa, A; Ticku, MK | 1 |
| Buckingham, SD; Rauh, J; Sattelle, DB; Schnee, M | 1 |
| Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Lu, HF; McKeon, AC; Rothman, SM; Xu, K; Yoon, KW | 1 |
| Carr, RL; Chambers, JE; Coats, JR; Couch, TA; Liu, J | 1 |
| Beart, PM; Crossley, KJ; Hirst, JJ; Walker, DW | 1 |
| Korpi, ER; Lüddens, H; Panula, P; Särkioja, T; Sinkkonen, ST; Tiihonen, J; Tupala, E; Uusi-Oukari, M | 1 |
| Das, P; Dillon, GH | 1 |
| Hartmann, J; Hildmann, O; Kiewert, C; Klein, J; Kumar, V; Naik, RS; Rueda, M | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Baptista-Hon, DT; Deeb, TZ; Gallacher, M; Hales, TG; Othman, NA; Perry, DC | 1 |
| Mehta, AK; Ticku, MK | 1 |
4 review(s) available for tert-butylbicyclophosphorothionate and picrotoxin
| Article | Year |
|---|---|
Chronic administration of negative modulators produces chemical kindling and GABAA receptor down-regulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Convulsants; Down-Regulation; Kindling, Neurologic; Pentylenetetrazole; Picrotoxin; Receptors, GABA-A; Sulfur Radioisotopes | 1990 |
Interactions of pyrethroid insecticides with chloride ionophore-associated binding sites.
Topics: Animals; Benzodiazepinones; Brain; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Drug Interactions; Guinea Pigs; Ion Channels; Picrotoxin; Pyrethrins; Radioligand Assay; Rats; Receptors, GABA-A; Sesterterpenes | 1985 |
[GABA receptors in the central nervous system. Biochemical and pharmacological aspects].
Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Receptors, GABA-A | 1987 |
[The clinical pharmacology of the GABAergic system (I)].
Topics: Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Humans; Picrotoxin; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission | 1994 |
51 other study(ies) available for tert-butylbicyclophosphorothionate and picrotoxin
| Article | Year |
|---|---|
Characterization of bicuculline/baclofen-insensitive gamma-aminobutyric acid receptors expressed in Xenopus oocytes. I. Effects of Cl- channel inhibitors.
Topics: Animals; Baclofen; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chloride Channels; Chlorides; Cloning, Molecular; Ion Channels; Membrane Proteins; Ovum; Picrotoxin; Rats; Receptors, GABA-A; Retina; RNA; Xenopus | 1992 |
Prolonged exposure to GABA activates GABA-gated chloride channels in the presence of channel-blocking convulsants.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Convulsants; Endrin; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sesterterpenes; Xenopus | 1991 |
t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Barbiturates; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Ethanol; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Proteins; Mice; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sleep | 1991 |
The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.
Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; gamma-Aminobutyric Acid; Male; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Inbred Strains | 1990 |
Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Membranes; Picrotoxin; Pregnenolone; Protein Binding; Rats; Rats, Inbred F344; Receptors, GABA-A; Sulfur Radioisotopes; Synaptosomes | 1990 |
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Flunitrazepam; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1989 |
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; Frontal Lobe; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Muscimol; Pentobarbital; Picrotoxin; Receptors, GABA-A; Seizures; Species Specificity; Synaptosomes | 1989 |
The modulation by chlormethiazole of the GABAA-receptor complex in rat brain.
Topics: Animals; Baclofen; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; CLC-2 Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A | 1989 |
A progesterone metabolite enhances the activity of the GABAA receptor complex at the pituitary level.
Topics: 5-alpha-Dihydroprogesterone; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; In Vitro Techniques; Male; Membranes; Muscimol; Picrotoxin; Pituitary Gland, Anterior; Pregnanediones; Progesterone; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
[Role of Cl-ionophore subunit in the functioning of GABA-benzodiazepine receptors].
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; In Vitro Techniques; Ionophores; Ligands; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Picrotoxin; Receptors, GABA-A; Sodium Chloride | 1989 |
Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Ethanol; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Spinal Cord | 1987 |
Ontogenesis and properties of the convulsant recognition site(s) of the gamma-aminobutyric acid (GABA) receptor complex in chicken embryo.
Topics: Aging; Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Convulsants; Endrin; Kinetics; Membranes; Picrotoxin; Receptors, GABA-A; Sesterterpenes | 1988 |
t-[35S]butylbicyclophosphorothionate binding sites in invertebrate tissues.
Topics: Animals; Astacoidea; Barbiturates; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Head; Houseflies; Membranes; Muscles; Picrotoxin; Sulfur Radioisotopes; Time Factors | 1989 |
Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Insecticides; Male; Mice; Mice, Inbred ICR; Picrotoxin; Receptors, GABA-A | 1985 |
Effect of ethanol on the binding of 35S-T-butylbicyclophosphorothionate to mouse brain membranes.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cerebellum; Cerebral Cortex; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Picrotoxin; Receptors, GABA-A | 1986 |
Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?
Topics: Adrenal Glands; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Male; Muscimol; Picrotoxin; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1987 |
Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport.
Topics: Animals; Bicuculline; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Insecticides; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome | 1988 |
Multiple [35S]t-butylbicyclophosphorothionate binding sites in rat and chicken cerebral hemispheres.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chickens; Kinetics; Mathematics; Membranes; Picrotoxin; Rats | 1985 |
gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]-t-butylbicyclophosphorothionate binding to cerebellar granule cells.
Topics: Animals; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Muscimol; Picrotoxin; Rats; Sulfur Radioisotopes; Temperature | 1985 |
Interactions of lindane, toxaphene and cyclodienes with brain-specific t-butylbicyclophosphorothionate receptor.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Endrin; Hexachlorocyclohexane; Insecticides; Isomerism; Kinetics; Microsomes; NADP; Picrotoxin; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Toxaphene | 1984 |
Light microscopic autoradiographic identification of picrotoxin/barbiturate binding sites in rat brain with [35S]t-butyl-bicyclophosphothionate.
Topics: Animals; Autoradiography; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Neurotransmitter; Tissue Distribution | 1983 |
Stereospecific action of pyrethroid insecticides on the gamma-aminobutyric acid receptor-ionophore complex.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Insecticides; Ionophores; Picrotoxin; Protein Binding; Pyrethrins; Rats; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes | 1983 |
Saturable binding of 35S-t-butylbicyclophosphorothionate to the sites linked to the GABA receptor and the interaction with GABAergic agents.
Topics: Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfur Radioisotopes; Triazines | 1984 |
Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex.
Topics: Animals; Azoles; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Drug Interactions; Ionophores; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sesterterpenes; Tetrazoles | 1984 |
RO5-4864 inhibits the binding of [35S]t-butylbicyclophosphorothionate to rat brain membranes.
Topics: Androstanes; Animals; Azasteroids; Benzodiazepinones; Bicuculline; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats | 1984 |
Alkyl-substituted gamma-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore.
Topics: 4-Butyrolactone; Animals; Barbiturates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Furans; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Male; Membranes; Picrotoxin; Rats; Rats, Inbred Strains | 1984 |
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; Diazepam; Etomidate; gamma-Aminobutyric Acid; Male; Membranes; Pentobarbital; Picrotoxin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sesterterpenes | 1984 |
[4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Humans; Ion Channels; Ligands; Picrotoxin; Quinoxalines; Rats; Receptors, GABA-A; Zinc | 1995 |
Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chlorides; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channels; Kidney; Kinetics; Patch-Clamp Techniques; Picrotoxin; Rats; Receptors, GABA-A | 1995 |
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromouracil; Convulsants; Dehydroepiandrosterone; Male; Mice; Mice, Inbred ICR; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Seizures; Synaptic Membranes | 1994 |
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists.
Topics: Analysis of Variance; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Electroshock; Escape Reaction; Flumazenil; GABA-A Receptor Agonists; Hippocampus; Male; Picrotoxin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sesterterpenes; Stress, Psychological; Strychnine; Sulfur Radioisotopes; Tritium | 1994 |
GABAA receptor stimulation enhances NMDA-induced Ca2+ influx in mouse cerebral cortical neurons in primary culture.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebral Cortex; Chloride Channels; Dizocilpine Maleate; Dose-Response Relationship, Drug; GABA Agonists; Isonicotinic Acids; Mice; Muscimol; N-Methylaspartate; Neurons; Picrotoxin; Potassium; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1994 |
Age-related changes of GABA-activated chloride channel properties in brain cortex synaptic plasma membrane: evidence for phospholipase involvement.
Topics: Aging; Animals; Arachidonic Acid; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Chlorides; Convulsants; Diglycerides; gamma-Aminobutyric Acid; Kinetics; Muscimol; Phospholipases; Picrotoxin; Rats; Rats, Wistar; Sulfur Radioisotopes; Synaptic Membranes; Synaptosomes | 1994 |
Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Convulsants; DNA Primers; DNA, Complementary; Drosophila melanogaster; Female; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression; Macromolecular Substances; Molecular Sequence Data; Muscimol; Oocytes; Pentobarbital; Picrotoxin; Polymerase Chain Reaction; Receptors, GABA; Receptors, GABA-A; Transcription, Genetic; Xenopus laevis | 1994 |
Studies on picrotoxin binding sites of GABAA receptors in rat cortical synaptoneurosomes.
Topics: Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorine; Desoxycorticosterone; Diazepam; In Vitro Techniques; Male; Membranes; Muscimol; Pentobarbital; Picrotoxin; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Synaptosomes | 1994 |
Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cerebellum; Cloning, Molecular; Convulsants; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Humans; Kidney; Muscimol; Mutation; Picrotoxin; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1993 |
Autoradiographic study of neurosteroid binding sites labelled with [35S]-TBPS in brain of different species.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Female; Guinea Pigs; Male; Mesencephalon; Mice; Mice, Inbred C3H; Organ Specificity; Picrotoxin; Pregnanolone; Rats; Rats, Wistar; Receptors, Steroid; Species Specificity; Sulfur Radioisotopes | 1993 |
A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; Dose-Response Relationship, Drug; GABA Modulators; Hypnotics and Sedatives; Male; Muscle Relaxation; Pentobarbital; Picrotoxin; Rats; Receptors, GABA-A; Seizures; Sesterterpenes; Triazoles | 1996 |
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis | 1996 |
Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebellum; Cerebral Cortex; Chlorides; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Male; Mice; Mice, Inbred C57BL; Picrotoxin; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Pharmacology of skeletal muscle GABA-gated chloride channels in the cockroach Periplaneta americana.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isonicotinic Acids; Male; Motor Neurons; Muscle, Skeletal; Periplaneta; Picrotoxin; Receptors, GABA; Sesterterpenes | 1997 |
Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Convulsants; Electrophysiology; Female; Fluorine Compounds; Furans; GABA Modulators; Hippocampus; Mice; Neurons; Picrotoxin; Rats; Receptors, GABA-A; Structure-Activity Relationship | 1998 |
The interaction of chlorinated alicyclic insecticides with brain GABA(A) receptors in channel catfish (Ictalurus punctatus).
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Edetic Acid; GABA-A Receptor Antagonists; Hydrocarbons, Chlorinated; Ictaluridae; Insecticides; Kinetics; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes | 1999 |
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Fetus; Frontal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Sheep; Sulfur Radioisotopes | 2000 |
Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Chickens; Convulsants; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes; Thalamus; Tritium | 2001 |
Molecular determinants of picrotoxin inhibition of 5-hydroxytryptamine type 3 receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Gene Expression Regulation; Humans; Ion Channel Gating; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Picrotoxin; Receptors, GABA-A; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Species Specificity; Structure-Activity Relationship; Threonine | 2005 |
Role of GABAergic antagonism in the neuroprotective effects of bilobalide.
Topics: Animals; Area Under Curve; Bicuculline; Brain Edema; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyclopentanes; Drug Interactions; Excitatory Amino Acid Agonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; Ginkgolides; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Nonlinear Dynamics; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptosomes | 2007 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.
Topics: Bicuculline; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Receptors, Serotonin, 5-HT3 | 2012 |
Characterization of the picrotoxin site of GABAA receptors.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Kinetics; Membranes; Nitriles; Picrotoxin; Radioligand Assay; Rats; Receptors, GABA-A; Specimen Handling; Statistics as Topic; Sulfur Radioisotopes | 2001 |