Compounds > tert-butylbicyclophosphorothionate
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tert-butylbicyclophosphorothionate and gamma-aminobutyric acid

tert-butylbicyclophosphorothionate has been researched along with gamma-aminobutyric acid in 162 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Research

Studies (162)

TimeframeStudies, this research(%)All Research%
pre-199068 (41.98)18.7374
1990's74 (45.68)18.2507
2000's18 (11.11)29.6817
2010's2 (1.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM1
Ehrmann, ML; Mileson, BE; Schwartz, RD1
Biggio, G; Concas, A; Mascia, MP; Pepitoni, S; Sanna, E; Serra, M1
Cadoni, C; Gee, KW1
Biggio, G; Concas, A; Foddi, MC; Ghiani, CA; Melis, MA; Motzo, C; Sanna, E; Serra, M1
Biggio, G; Concas, A; Maciocco, E; Mascia, MP; Santoro, G1
Biggio, G; Concas, A; Gessa, GL; Peduto, VA; Santoro, G1
Gee, KW; Lan, NC1
Biggio, G; Concas, A; Sanna, E; Serra, GP; Serra, M1
Lummis, SC; Rauh, JJ; Sattelle, DB; Wong, JF1
Fernandes, G; Mhatre, MC; Ticku, MK1
Bloomquist, JR; Grubs, RE; Knipple, DC; Soderlund, DM1
Biggio, G; Concas, A; Sanna, E; Serra, M1
Buckingham, SD; Lummis, SC; Rauh, JJ; Sattelle, DB1
Biggio, G; Concas, A; Sanna, E; Santoro, G; Serra, M1
Niles, L1
Eshleman, AJ; Murray, TF2
McIntyre, T; Skolnick, P1
Galpern, WR; Greenblatt, DJ; Lumpkin, M; Miller, LG; Shader, RI1
Blakeman, DP; Im, WB1
Abendschein, KH; Dawson, R; Peris, J; Shawley, A1
de Costa, BR; Lewin, AH; Rice, KC; Schoenheimer, JA; Skolnick, P1
Canonaco, M; Maggi, A; Valenti, A1
Belelli, D; Gee, KW; McCauley, L1
Farb, DH; Farrant, M; Roca, DJ; Rozenberg, I1
Kulkarni, SK; Ticku, MK1
Barnard, EA; Devine, J; Macdonald, RL; Moss, SJ; Nayeem, N; Porter, NM; Smart, TG; Stephenson, FA1
Biggio, G; Concas, A; Mascia, MP; Sanna, E; Santoro, G; Serra, M1
Danielou, G; Lloyd, GK; Thuret, F1
Edgar, PP; Schwartz, RD1
Biggio, G; Concas, A; Mascia, MP; Sanna, E; Serra, M1
Casida, JE; Seifert, J2
Barnes, EM; Tehrani, MH; Vaidyanathaswamy, R; Verkade, JG1
Havoundjian, H; Paul, SM; Skolnick, P2
Havoundjian, H; Skolnick, P; Trullas, R1
Häring, P; Möhler, H; Richards, JG; Schoch, P; Takacs, B1
Allan, AM; Bleck, V; Harris, RA; Huidobro-Toro, JP1
Barnard, EA; Bilbe, G; Houamed, K; Moss, SJ; Smart, TG; Van Renterghem, C1
Marvizón, JC; Skolnick, P1
McIntyre, TD; Skolnick, P; Trullas, R1
Casida, JE; Palmer, CJ1
Atsoggiu, T; Biggio, G; Concas, A; Pepitoni, S; Toffano, G1
Bleck, V; Harris, RA; Lewin, E; Peris, J; Zahniser, NR1
de Costa, BR; Lewin, AH; Rice, KC; Skolnick, P1
Biggio, G; Cau, A; Corda, MG; Laudani, U; Longoni, B; Paci, S; Salvadori, S1
Biggio, G; Concas, A; Corda, MG; Serra, M2
Evoniuk, G; Moody, EJ; Skolnick, P1
Biggio, G; Sanna, E; Serra, M1
Abel, MS; Blume, AJ; Garrett, KM1
Schneider, HH; Stephens, DN; Zimmermann, LN1
Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Robinson, TN; Stirling, JM1
Biggio, G; Pepitoni, S; Sanna, E; Serra, M1
Culp, S; Liljequist, S; Tabakoff, B2
Allan, AM; Buck, KJ; Harris, RA1
Saederup, E; Squires, RF5
Ho, IK; Hoskins, B; Ito, Y; Lim, DK1
Maksay, G; Ticku, MK3
Gallager, DW; Heninger, C1
Casida, JE; Ikeda, M; Laird, H; Malatynska, E; Obata, T; Palmer, CJ; Yamamura, HI1
Dalkara, T; Krnjevic, K; Saederup, E; Squires, RF1
Hamon, M1
Atsoggiu, T; Biggio, G; Concas, A; Serra, M1
Casida, JE; Gee, KW; Lawrence, LJ; Palmer, CJ; Wang, X; Yamamura, HI1
Komiskey, HL; Meyers, MB1
Bloomquist, JR; Soderlund, DM1
Schneider, HH; Stephens, DN1
Barnes, EM; Tehrani, MH1
Haefely, W; Möhler, H; Richards, JG; Schoch, P1
Cohen, RM; Havoundjian, H; Paul, SM; Skolnick, P1
Chiu, TH; Ito, M; Rosenberg, HC1
Gee, KW; Lawrence, LJ; Yamamura, HI2
Gee, KW1
Havoundjian, H; Paul, S; Skolnick, P; Trullas, R1
Eldefrawi, AT; Eldefrawi, ME; Gant, DB1
Stephenson, FA1
Crabbe, JC; Feller, DJ; Harris, RA1
Erdö, SL; Maksay, G1
Brinton, RE; Chang, WC; Gee, KW; McEwen, BS1
Maksay, G; Simonyi, M1
Allan, AM; Harris, RA1
Gallo, V; Guidotti, A; Vaccarino, F; Wise, BC1
Ramanjaneyulu, R; Ticku, MK2
Borea, PA; Karobath, M; Supavilai, P1
Casida, JE; Richardson, M; Saederup, E; Squires, RF1
Bymaster, FP; Squires, RF; Threlkeld, PG; Wong, DT1
King, RG; Olsen, RW1
Barnard, EA; Sigel, E1
Karobath, M; Supavilai, P1
Burke, TR; Rice, KC; Skolnick, P; Weissman, BA1
Braestrup, C; Nielsen, M1
Korpi, ER; Lüddens, H2
Frandsen, A; Pomés, A; Rodríguez-Farré, E; Sanfeliu, C; Schousboe, A; Suñol, C1
Chatterjee, SS; Dimpfel, W; Nöldner, M; Ticku, MK1
Carter, DB; Dillon, GH; Im, WB; McKinley, DD1
Ticku, MK; Yu, R2
Chen, JS; Gee, KW; Hawkinson, JE; Lan, NC; Liu, V; McCauley, LD1
Pecins-Thompson, M; Peris, J1
Samochocki, M; Strosznajder, J1
Im, WB; Pregenzer, JF; Thomsen, DR1
Cancedda, E; Corda, MG; Giorgi, O; Lecca, D; Orlandi, M1
Belelli, D; Chen, R; Lambert, JJ; Lan, NC; Peters, JA; Reyes, A1
Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Santoro, G1
Marco Igual, M1
Hu, XJ; Ticku, MK1
Corda, MG; Driscoll, P; Escorihuela, RM; Giorgi, O; Lecca, D; Orlandi, M1
Cancedda, E; Corda, MG; Giorgi, O1
Maksay, G; van Rijn, CM1
Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Ongini, E; Santoro, G1
Korpi, ER; Seeburg, PH1
Liljequist, S; Tabakoff, B1
Bouley, MG; Covey, DF; Holland, KD; Hu, Y; Isenberg, KE; Rodgers-Neame, NT; Zorumski, CF1
Finn, DA; Gee, KW1
Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G1
Corda, MG; Giorgi, O; Lecca, D; Orlandi, M; Serra, GP; Zhang, L1
Harris, CL; Quinn, MR1
Masonis, AE; McCarthy, MP1
Biggio, G; Casula, A; Maciocco, E; Murgia, A; Sanna, E; Tuligi, G; Usala, M1
Davies, PA; Hales, TG; Kirkness, EF1
Sousa, A; Ticku, MK1
Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W1
Buckingham, SD; Rauh, J; Sattelle, DB; Schnee, M1
Barnes, EM; Baumgartner, BJ; Tehrani, MH1
Banerjee, PK; Brailowsky, S; Olsen, RW; Snead, OC; Tillakaratne, NJ; Tobin, AJ1
Korpi, ER; Mäkelä, R; Wisden, W1
Biggio, G; Chessa, MF; Concas, A; Genazzani, AR; Mostallino, MC; Petraglia, F; Serra, M; Stomati, M1
Davidoff, RA; Hackman, JC; Holohean, AM; Katz, JL; Valeyev, AY; Wood, PM1
Olsen, RW; Sapp, DW; Srinivasan, S; Tobin, AJ1
Behrends, JC1
Beart, PM; Crossley, KJ; Hirst, JJ; Walker, DW1
Gillardin, J; Poisbeau, P; Rybalchenko, V; Schlichter, R; Verleye, M1
Carroll, SS; Li, YH; McEwen, BS; Orchinik, M; Weiland, NG1
Korpi, ER; Lüddens, H; Panula, P; Särkioja, T; Sinkkonen, ST; Tiihonen, J; Tupala, E; Uusi-Oukari, M1
Heikkilä, J; Korpi, ER; Lovinger, DM; Lüddens, H; Möykkynen, T; Uusi-Oukari, M1
Korpi, ER; Mäkelä, R; Soini, S; Uusi-Oukari, M1
Chigr, F; M'hamed, SB; Najimi, M1
Akk, G; Bracamontes, JR; Covey, DF; Darbandi-Tonkabon, R; Evers, AS; Hastings, WR; Manion, BD; Mennerick, SJ; Steinbach, JH; Zeng, CM1
Brussaard, AB; Koksma, JJ; Lüddens, H; Rosahl, TW; Smit, AB; van Kesteren, RE; Zwart, R1
Abuhamdah, S; Chazot, PL; Fürstner, A; Lees, G1
Hartmann, J; Hildmann, O; Kiewert, C; Klein, J; Kumar, V; Naik, RS; Rueda, M1
Atack, JR; McKernan, RM; Ohashi, Y1
Abe, S; Asada, T; Endo, K; Hori, T1
Korpi, ER; Linden, AM; Lüddens, H; Möykkynen, T; Rabe, H; Ranna, M; Saarelainen, KS; Sinkkonen, ST; Uusi-Oukari, M1
Galofré, M; García, DA; Suñol, C; Vendrell, I1
Chandra, D; Halonen, LM; Homanics, GE; Korpi, ER; Sinkkonen, ST1
Baptista-Hon, DT; Deeb, TZ; Gallacher, M; Hales, TG; Othman, NA; Perry, DC1
Mehta, AK; Ticku, MK1
Hashimoto, T; Iwamura, Y; Kiyoshi, T; Kohayakawa, H; Yoshida, N1

Reviews

7 review(s) available for tert-butylbicyclophosphorothionate and gamma-aminobutyric acid

ArticleYear
The role of receptor binding in drug discovery.
    Journal of natural products, 1993, Volume: 56, Issue:4

    Topics: Animals; Drug Design; Humans; Receptors, Drug

1993
"In vivo" inhibition of GABAergic transmission increases 35S-TBPS binding in the rat brain.
    Advances in experimental medicine and biology, 1991, Volume: 287

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Corpus Striatum; Denervation; Ethanol; gamma-Aminobutyric Acid; Substantia Nigra; Sulfur Radioisotopes; Synaptic Transmission

1991
2,6,7-Trioxabicyclo[2.2.2]octanes: chemistry, toxicology and action at the GABA-gated chloride channel.
    Advances in biochemical psychopharmacology, 1988, Volume: 45

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Convulsants; gamma-Aminobutyric Acid; Hydrolysis; Insecta; Ion Channels; Ligands; Structure-Activity Relationship

1988
[GABA receptors in the central nervous system. Biochemical and pharmacological aspects].
    L'Encephale, 1987, Volume: 13 Spec No

    Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Receptors, GABA-A

1987
Benzodiazepine receptors resolved.
    Experientia, 1986, Feb-15, Volume: 42, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Autoradiography; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Histocytochemistry; Humans; Immunologic Techniques; Ionophores; Muscimol; Neurons; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Spinal Cord; Synapses; Tissue Distribution

1986
Distinction of benzodiazepine receptor agonists and inverse agonists by binding studies in vitro.
    Advances in biochemical psychopharmacology, 1983, Volume: 38

    Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Etazolate; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Muscimol; Rats; Receptors, Cell Surface; Receptors, GABA-A

1983
[The clinical pharmacology of the GABAergic system (I)].
    Medicina clinica, 1994, Mar-12, Volume: 102, Issue:9

    Topics: Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Humans; Picrotoxin; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission

1994

Other Studies

155 other study(ies) available for tert-butylbicyclophosphorothionate and gamma-aminobutyric acid

ArticleYear
Alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: Animals; Autoradiography; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; gamma-Aminobutyric Acid; Gerbillinae; Ion Channel Gating; Ischemic Attack, Transient; Male; Membrane Proteins; Motor Activity; Muscimol

1992
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Culture Techniques; Epilepsy; gamma-Aminobutyric Acid; Isoniazid; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses; Synaptic Transmission; Valproic Acid

1992
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.
    European journal of pharmacology, 1992, Oct-01, Volume: 227, Issue:2

    Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism

1992
Pharmacology of gamma-aminobutyric acidA receptor complex after the in vivo administration of the anxioselective and anticonvulsant beta-carboline derivative abecarnil.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Chlorides; Exploratory Behavior; gamma-Aminobutyric Acid; In Vitro Techniques; Isoniazid; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Physiological

1992
The general anesthetic propofol: a biochemical tool to study the function of the GABA-coupled chloride channel.
    Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A

    Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Male; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Inbred Strains

1992
Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain.
    Anesthesiology, 1991, Volume: 75, Issue:6

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membrane Proteins; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1991
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
    Molecular pharmacology, 1991, Volume: 40, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes

1991
Pharmacology of insect GABA receptors.
    Neurochemical research, 1991, Volume: 16, Issue:3

    Topics: Acetylcholine; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Female; Flunitrazepam; gamma-Aminobutyric Acid; Houseflies; Insecticides; Male; Membrane Proteins; Nervous System; Neurons; Periplaneta; Pregnanes; Receptors, GABA-A; Synapses

1991
Aging reduces the mRNA of alpha 1 GABAA receptor subunit in rat cerebral cortex.
    European journal of pharmacology, 1991, Oct-14, Volume: 208, Issue:2

    Topics: Aging; Animals; Blotting, Northern; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression Regulation; Macromolecular Substances; Male; Rats; Rats, Inbred F344; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic; Tritium

1991
Prolonged exposure to GABA activates GABA-gated chloride channels in the presence of channel-blocking convulsants.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Convulsants; Endrin; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sesterterpenes; Xenopus

1991
In vivo administration of ethanol enhances the function of the gamma-aminobutyric acid-dependent chloride channel in the rat cerebral cortex.
    Journal of neurochemistry, 1990, Volume: 54, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Diazepam; Ethanol; gamma-Aminobutyric Acid; Ion Channels; Isoniazid; Male; Rats; Rats, Inbred Strains

1990
Blocking actions of heptachlor at an insect central nervous system GABA receptor.
    Proceedings of the Royal Society of London. Series B, Biological sciences, 1990, May-22, Volume: 240, Issue:1297

    Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chloride Channels; Chlorides; Cockroaches; Electrophysiology; gamma-Aminobutyric Acid; Ganglia; Heptachlor; Houseflies; Ion Channels; Membrane Potentials; Membrane Proteins; Motor Neurons; Nervous System Physiological Phenomena; Rats; Receptors, GABA-A

1990
Ex vivo binding of t-[35S )butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Diazepam; Drug Interactions; Ethanol; gamma-Aminobutyric Acid; Ion Channels; Isoniazid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sulfur Radioisotopes

1991
Melatonin interaction with the benzodiazepine-GABA receptor complex in the CNS.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chlorides; Diazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ion Channels; Melatonin; Muscimol; Prosencephalon; Rats; Receptors, GABA-A; Serotonin; Synaptosomes

1991
Pyrethroid insecticides indirectly inhibit GABA-dependent 36Cl- influx in synaptoneurosomes from the trout brain.
    Neuropharmacology, 1991, Volume: 30, Issue:12A

    Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorine; Depression, Chemical; gamma-Aminobutyric Acid; In Vitro Techniques; Insecticides; Nerve Tissue Proteins; Nitriles; Pyrethrins; Salmon; Synaptosomes; Tetrodotoxin; Veratridine

1991
t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines.
    Journal of neurochemistry, 1991, Volume: 56, Issue:1

    Topics: Animals; Barbiturates; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Ethanol; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Proteins; Mice; Pentobarbital; Phenobarbital; Picrotoxin; Receptors, GABA-A; Sesterterpenes; Sleep

1991
Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging.
    Journal of neurochemistry, 1991, Volume: 56, Issue:4

    Topics: Aging; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyric Acid; Kinetics; Lorazepam; Male; Mice; Mice, Inbred Strains; Quinolines; Receptors, GABA-A

1991
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
    Molecular pharmacology, 1991, Volume: 39, Issue:3

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes

1991
Regulation of 35S-TBPS binding by bicuculline is region specific in rat brain.
    Life sciences, 1991, Volume: 49, Issue:11

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Male; Microsomes; Rats; Rats, Inbred Strains; Substantia Nigra; Sulfur Radioisotopes

1991
Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes .
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:5

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chemical Phenomena; Chemistry; Chlorides; Convulsants; gamma-Aminobutyric Acid; Ion Channel Gating; Ligands; Male; Models, Molecular; Rats; Rats, Inbred Strains

1991
Effects of progesterone on [35S] t-butylbicyclophosphorothionate binding in some forebrain areas of the female rat and its correlation to aggressive behavior.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:3

    Topics: Aggression; Amygdala; Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dihydrotestosterone; Female; gamma-Aminobutyric Acid; Hypothalamus; Ovariectomy; Progesterone; Rats; Rats, Inbred Strains

1990
Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Animals; Benzodiazepinones; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Convulsants; gamma-Aminobutyric Acid; Male; Pregnanediol; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains

1990
Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex.
    Molecular pharmacology, 1990, Volume: 37, Issue:1

    Topics: Allosteric Regulation; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Down-Regulation; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A

1990
Dependence on gamma-aminobutyric acid of pyrethroid and 4'-chlorodiazepam modulation of the binding of t-[35S]butylbicyclophosphorothionate in piscine brain.
    Neuropharmacology, 1990, Volume: 29, Issue:7

    Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; gamma-Aminobutyric Acid; Kinetics; Nitriles; Pyrethrins; Receptors, GABA-A; Trout

1990
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
    Brain research, 1990, Jun-11, Volume: 519, Issue:1-2

    Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation

1990
Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties.
    European journal of pharmacology, 1990, Jul-31, Volume: 189, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Barbiturates; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Line; Chlorides; Clone Cells; Convulsants; DNA; gamma-Aminobutyric Acid; Membrane Potentials; Muscimol; Neurons; Plasmids; Receptors, GABA-A; Spinal Cord; Transfection

1990
The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.
    Journal of neurochemistry, 1990, Volume: 55, Issue:6

    Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; gamma-Aminobutyric Acid; Male; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnanediones; Propofol; Rats; Rats, Inbred Strains

1990
The activity of zolpidem and other hypnotics within the gamma-aminobutyric acid (GABAA) receptor supramolecular complex, as determined by 35S-t-butylbicyclophosphorothionate (35S-TBPS) binding to rat cerebral cortex membranes.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zolpidem

1990
Localization and characterization of 35S-t-butylbicyclophosphorothionate binding in rat brain: an autoradiographic study.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:2

    Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Tissue Distribution

1990
Diazepam enhances bicuculline-induced increase of t-[35S]butylbicyclophosphorothionate binding in unwashed membrane preparations from rat cerebral cortex.
    Neuroscience letters, 1990, Apr-20, Volume: 112, Issue:1

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Convulsants; Diazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Subcellular Fractions

1990
Basic neuroproteins modulate TBPS recognition site.
    European journal of pharmacology, 1986, Mar-11, Volume: 122, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Calcium Chloride; Cattle; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Membranes; Nerve Tissue Proteins; Rats; Receptors, GABA-A

1986
Interaction of t-butylbicyclophosphorothionate with gamma-aminobutyric acid-gated chloride channels in cultured cerebral neurons.
    Journal of neurochemistry, 1986, Volume: 46, Issue:5

    Topics: Animals; Anions; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cells, Cultured; Chick Embryo; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Neurons

1986
The permeability of gamma-aminobutyric acid-gated chloride channels is described by the binding of a "cage" convulsant, t-butylbicyclophosphoro[35S]thionate.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:23

    Topics: Animals; Anions; Anura; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chlorides; gamma-Aminobutyric Acid; Ganglia, Spinal; Ion Channels; Male; Neurons; Permeability; Rats

1986
Stress-induced changes in t-[35S]butylbicyclophosphorothionate binding to gamma-aminobutyric acid-gated chloride channels are mimicked by in vitro occupation of benzodiazepine receptors.
    Journal of neurochemistry, 1987, Volume: 49, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Ion Channels; Kinetics; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming

1987
Structure and location of a GABA-A receptor complex in the central nervous system.
    Journal of receptor research, 1987, Volume: 7, Issue:1-4

    Topics: Animals; Antibodies, Monoclonal; Binding Sites; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Epitopes; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A

1987
Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:3

    Topics: Alcohols; Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred DBA; Receptors, GABA-A; Structure-Activity Relationship

1987
Functional expression in the Xenopus oocyte of messenger ribonucleic acids encoding brain neurotransmitter receptors: further characterisation of the implanted GABA receptor.
    Neuropharmacology, 1987, Volume: 26, Issue:7B

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Chlorides; Cloning, Molecular; DNA; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression Regulation; Glycosylation; Ion Channels; Oocytes; Poly A; Receptors, GABA-A; RNA; RNA, Messenger; Xenopus

1987
Enhancement of t-[35S]butylbicyclophosphorothionate and [3H]strychnine binding by monovalent anions reveals similarities between gamma-aminobutyric acid- and glycine-gated chloride channels.
    Journal of neurochemistry, 1988, Volume: 50, Issue:5

    Topics: Animals; Anions; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cell Membrane Permeability; Chlorides; gamma-Aminobutyric Acid; Glycine; Ion Channels; Male; Medulla Oblongata; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Sulfur Radioisotopes; Tritium

1988
Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines.
    Journal of neurochemistry, 1988, Volume: 51, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Heart; Ion Channels; Male; Mice; Mice, Mutant Strains; Receptors, GABA-A; Sleep

1988
Aging reduces the GABA-dependent 36Cl- flux in rat brain membrane vesicles.
    Life sciences, 1988, Volume: 43, Issue:22

    Topics: Aging; Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Cerebral Cortex; Chlorides; gamma-Aminobutyric Acid; Hippocampus; Ion Channels; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A

1988
Chemical kindling decreases GABA-activated chloride channels of mouse brain.
    European journal of pharmacology, 1989, Jan-24, Volume: 160, Issue:1

    Topics: Animals; Autoradiography; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; gamma-Aminobutyric Acid; Ion Channels; Kindling, Neurologic; Male; Mice; Mice, Inbred ICR; Muscimol; Sulfur Radioisotopes

1989
meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore.
    Molecular pharmacology, 1989, Volume: 35, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chloride Channels; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isothiocyanates; Ligands; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiocyanates

1989
Distribution and pharmacological properties of the GABAA/benzodiazepine/chloride ionophore receptor complex in the brain of the fish Anguilla anguilla.
    Journal of neurochemistry, 1989, Volume: 52, Issue:4

    Topics: Anguilla; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Ionophores; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Tissue Distribution

1989
Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors.
    European journal of pharmacology, 1989, Feb-28, Volume: 161, Issue:2-3

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Muscimol; Pyridines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission; Zolpidem

1989
Ultraviolet irradiation selectively disrupts the gamma-aminobutyric acid/benzodiazepine receptor-linked chloride ionophore.
    Molecular pharmacology, 1989, Volume: 35, Issue:5

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Chloride Channels; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Ultraviolet Rays

1989
Isoniazid, an inhibitor of GABAergic transmission, enhances [35S]TBPS binding in rat cerebral cortex.
    European journal of pharmacology, 1989, May-19, Volume: 164, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Convulsants; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Membranes; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Synaptic Transmission

1989
Differential effects of iodide and chloride on allosteric interactions of the GABAA receptor.
    Journal of neurochemistry, 1989, Volume: 53, Issue:3

    Topics: Allosteric Regulation; Animals; Anions; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Chlorides; Diazepam; gamma-Aminobutyric Acid; Iodides; Male; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A

1989
Partial GABA agonist activity of SR 95531 on the binding of [35S]TBPS, [3H]DMCM and [3H]lormetazepam to rat brain membranes.
    Biochemical pharmacology, 1989, Sep-01, Volume: 38, Issue:17

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Lorazepam; Male; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1989
The modulation by chlormethiazole of the GABAA-receptor complex in rat brain.
    British journal of pharmacology, 1989, Volume: 98, Issue:1

    Topics: Animals; Baclofen; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; CLC-2 Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A

1989
Dramatic increase in nigral t-[35S]butylbicyclophosphorothionate binding sites elicited by the degeneration of the striato-nigral GABAergic pathway: reversal by diazepam.
    Brain research, 1989, Oct-30, Volume: 501, Issue:1

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra

1989
The effect of ethanol on 35S-TBPS binding to mouse brain membranes in the presence of chloride.
    Pharmacology & toxicology, 1989, Volume: 65, Issue:5

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Benzodiazepinones; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Diazepam; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Substance-Related Disorders; Sulfur Radioisotopes

1989
Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx.
    European journal of pharmacology, 1989, Feb-07, Volume: 160, Issue:3

    Topics: Anesthesia; Animals; Benzyl Alcohols; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Chlorine; gamma-Aminobutyric Acid; Male; Membrane Fluidity; Membranes; Mice; Mice, Inbred ICR; Muscimol; Radioisotopes; Stearates; Stearic Acids; Synaptosomes; Temperature

1989
Antidepressants and metabolites that block GABAA receptors coupled to 35S-t-butylbicyclophosphorothionate binding sites in rat brain.
    Brain research, 1988, Feb-16, Volume: 441, Issue:1-2

    Topics: Animals; Antidepressive Agents; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; gamma-Aminobutyric Acid; Kinetics; Rats; Receptors, GABA-A; Structure-Activity Relationship; Sulfur Radioisotopes

1988
Bicuculline up-regulation of GABAA receptors in rat brain.
    Journal of neurochemistry, 1988, Volume: 51, Issue:1

    Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Corpus Striatum; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Male; Muscimol; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra; Synaptic Membranes

1988
CNS depressants accelerate the dissociation of 35S-TBPS binding and GABA enhances their displacing potencies.
    Life sciences, 1988, Volume: 43, Issue:16

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chloride Channels; Chlorides; Convulsants; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Membrane Proteins; Rats; Receptors, GABA-A

1988
Altered gamma-aminobutyric acid/benzodiazepine interaction after chronic diazepam exposure.
    Neuropharmacology, 1988, Volume: 27, Issue:10

    Topics: Animals; Benzodiazepines; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors

1988
Modulation of gamma-aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsants.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Convulsants; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1988
Iontophoretic studies on rat hippocampus with some novel GABA antagonists.
    Life sciences, 1986, Aug-04, Volume: 39, Issue:5

    Topics: Action Potentials; Amoxapine; Animals; Benzothiadiazines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Iontophoresis; Phenanthrolines; Rats; Strychnine; Thiazines

1986
Changes of 36Cl- flux and 35S-TBPS binding induced by stress and gabaergic drugs.
    Advances in biochemical psychopharmacology, 1988, Volume: 45

    Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cerebral Cortex; Chlorides; Convulsants; gamma-Aminobutyric Acid; Male; Neurons; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological

1988
Foot-shock stress and anxiogenic beta-carbolines increase t-[35S]butylbicyclophosphorothionate binding in the rat cerebral cortex, an effect opposite to anxiolytics and gamma-aminobutyric acid mimetics.
    Journal of neurochemistry, 1988, Volume: 51, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Diazepam; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological

1988
Dissociation of [35S]t-butylbicyclophosphorothionate binding differentiates convulsant and depressant drugs that modulate GABAergic transmission.
    Journal of neurochemistry, 1985, Volume: 44, Issue:2

    Topics: Animals; Barbiturates; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Etazolate; Etomidate; gamma-Aminobutyric Acid; Kinetics; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A

1985
t-[3H]butylbicycloorthobenzoate: new radioligand probe for the gamma-aminobutyric acid-regulated chloride ionophore.
    Journal of neurochemistry, 1985, Volume: 45, Issue:3

    Topics: Androstanes; Animals; Azasteroids; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chemical Phenomena; Chemistry; Chlorides; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Ionophores; Kinetics; Male; Rats; Receptors, GABA-A; Temperature

1985
Aging: effect on the interaction of ethanol and pentobarbital with the benzodiazepine-GABA receptor-ionophore complex.
    Brain research, 1985, Sep-23, Volume: 343, Issue:2

    Topics: Aging; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Ionophores; Kinetics; Male; Pentobarbital; Rats; Rats, Inbred F344; Receptors, GABA-A; Temperature

1985
Regulation of [35S]t-butylbicyclophosphorothionate binding sites in rat brain by GABA, pyrethroid and barbiturate.
    European journal of pharmacology, 1985, Sep-24, Volume: 115, Issue:2-3

    Topics: Animals; Barbiturates; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; In Vitro Techniques; Insecticides; Kinetics; Male; Pyrethrins; Rats; Receptors, GABA-A

1985
GABA, depressants and chloride ions affect the rate of dissociation of 35S-t-butylbicyclophosphorothionate binding.
    Life sciences, 1985, Dec-09, Volume: 37, Issue:23

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Central Nervous System Depressants; Cerebral Cortex; Chlorides; Convulsants; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A

1985
Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles.
    Biochemical and biophysical research communications, 1985, Nov-27, Volume: 133, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Insecticides; Male; Mice; Mice, Inbred ICR; Picrotoxin; Receptors, GABA-A

1985
Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity.
    Psychopharmacology, 1985, Volume: 87, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Diazepam; Drug Tolerance; Female; gamma-Aminobutyric Acid; Lorazepam; Male; Mice; Punishment; Receptors, GABA-A

1985
Ontogeny of the GABA receptor complex in chick brain: studies in vivo and in vitro.
    Brain research, 1986, Volume: 390, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Receptors, GABA-A

1986
Differential sensitivity of "central" and "peripheral" type benzodiazepine receptors to phospholipase A2.
    Journal of neurochemistry, 1986, Volume: 46, Issue:3

    Topics: Animals; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Myocardium; Pentobarbital; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Acute, stress-induced changes in the benzodiazepine/gamma-aminobutyric acid receptor complex are confined to the chloride ionophore.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bromides; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Iodides; Ionophores; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Sulfur Radioisotopes; Swimming; Tritium

1986
Effect of ethanol on the binding of 35S-T-butylbicyclophosphorothionate to mouse brain membranes.
    Life sciences, 1986, May-26, Volume: 38, Issue:21

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cerebellum; Cerebral Cortex; Ethanol; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Picrotoxin; Receptors, GABA-A

1986
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
    Neurochemical research, 1986, Volume: 11, Issue:5

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution

1986
Modulation of the chloride ionophore by benzodiazepine receptor ligands: influence of gamma-aminobutyric acid and ligand efficacy.
    Molecular pharmacology, 1986, Volume: 30, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cerebral Cortex; Chlorides; Clonazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Kinetics; Ligands; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sulfur Radioisotopes; Tritium

1986
Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:3

    Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; gamma-Aminobutyric Acid; Kinetics; Male; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
The benzodiazepine/GABA receptor complex in anxiety.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Animals; Anxiety; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Receptors, GABA-A; Stress, Physiological

1986
Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport.
    Toxicology and applied pharmacology, 1987, Volume: 88, Issue:3

    Topics: Animals; Bicuculline; Biological Transport; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Insecticides; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
GABAA receptor blockers reverse the inhibitory effect of GABA on brain-specific [35S]TBPS binding.
    Brain research, 1987, Jun-30, Volume: 414, Issue:2

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Rats; Receptors, GABA-A; Subcellular Fractions

1987
Progress towards the understanding of the GABAA receptor structure.
    Journal of receptor research, 1987, Volume: 7, Issue:1-4

    Topics: Allosteric Site; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cholic Acids; Deoxycholic Acid; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Protein Binding; Receptors, GABA-A

1987
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
    European journal of pharmacology, 1988, Nov-22, Volume: 157, Issue:2-3

    Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Ethanol; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Picrotoxin; Seizures; Substance Withdrawal Syndrome

1988
[35S]TBPS binding to membranes of the female sex organs: modulation of chloride ionophore by GABA and pentobarbital.
    European journal of pharmacology, 1988, Mar-01, Volume: 147, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Convulsants; Fallopian Tubes; Female; gamma-Aminobutyric Acid; Genitalia, Female; In Vitro Techniques; Ionophores; Membranes; Ovary; Pentobarbital; Rats; Rats, Inbred Strains; Uterus

1988
GABA-dependent modulation of the Cl- ionophore by steroids in rat brain.
    European journal of pharmacology, 1987, Apr-29, Volume: 136, Issue:3

    Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Cholesterol; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Male; Rats; Rats, Inbred Strains; Steroids

1987
Kinetic regulation of convulsant (TBPS) binding by GABAergic agents.
    Molecular pharmacology, 1986, Volume: 30, Issue:4

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cations, Monovalent; Cell Membrane; Cerebral Cortex; gamma-Aminobutyric Acid; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synaptosomes

1986
Gamma-aminobutyric acid and alcohol actions: neurochemical studies of long sleep and short sleep mice.
    Life sciences, 1986, Nov-24, Volume: 39, Issue:21

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Chlorides; Diencephalon; Drug Synergism; Ethanol; Female; gamma-Aminobutyric Acid; Hippocampus; Mice; Muscimol; Pentobarbital; Sleep; Telencephalon

1986
gamma-Aminobutyric acid- and benzodiazepine-induced modulation of [35S]-t-butylbicyclophosphorothionate binding to cerebellar granule cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1985, Volume: 5, Issue:9

    Topics: Animals; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Carbolines; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Muscimol; Picrotoxin; Rats; Sulfur Radioisotopes; Temperature

1985
Differential interactions of GABA agonists, depressant and convulsant drugs with [35S]-t-butylbicyclophosphorothionate binding sites in cortex and cerebellum.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:1

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Central Nervous System Depressants; Cerebellum; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Male; Mitochondria; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Transmission; Thiocyanates

1984
Benzodiazepine anticonvulsant action: gamma-aminobutyric acid-dependent modulation of the chloride ionophore.
    Biochemical and biophysical research communications, 1984, Sep-28, Volume: 123, Issue:3

    Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cerebral Cortex; Clonazepam; gamma-Aminobutyric Acid; Ionophores; Kinetics; Rats; Receptors, GABA-A

1984
[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.
    Molecular pharmacology, 1983, Volume: 23, Issue:2

    Topics: Androstanes; Animals; Azasteroids; Barbiturates; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Bromates; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Rats; Receptors, Cell Surface; Receptors, GABA-A; Temperature; Tissue Distribution

1983
Saturable binding of 35S-t-butylbicyclophosphorothionate to the sites linked to the GABA receptor and the interaction with GABAergic agents.
    Life sciences, 1984, Feb-27, Volume: 34, Issue:9

    Topics: Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Sulfur Radioisotopes; Triazines

1984
Solubilization of convulsant/barbiturate binding activity on the gamma-aminobutyric acid/benzodiazepine receptor complex.
    Biochemical and biophysical research communications, 1984, Mar-15, Volume: 119, Issue:2

    Topics: Animals; Barbiturates; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; Intracellular Membranes; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter

1984
A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions.
    The Journal of biological chemistry, 1984, Jun-10, Volume: 259, Issue:11

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Methods; Muscimol; Pentobarbital; Receptors, Cell Surface; Receptors, GABA-A; Solubility

1984
[35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1984, Volume: 4, Issue:5

    Topics: Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Cerebral Cortex; gamma-Aminobutyric Acid; Kinetics; Macromolecular Substances; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1984
Alkyl-substituted gamma-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: 4-Butyrolactone; Animals; Barbiturates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Furans; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Male; Membranes; Picrotoxin; Rats; Rats, Inbred Strains

1984
The molecular target size of brain TBPS binding sites.
    European journal of pharmacology, 1983, Dec-23, Volume: 96, Issue:3-4

    Topics: Animals; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; gamma-Aminobutyric Acid; Molecular Weight; Rats

1983
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site.
    Journal of neurochemistry, 1984, Volume: 42, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Convulsants; Diazepam; Etomidate; gamma-Aminobutyric Acid; Male; Membranes; Pentobarbital; Picrotoxin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sesterterpenes

1984
GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:10

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Embryo, Mammalian; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Kidney; Pyridazines; Rats; Receptors, GABA-A; Recombination, Genetic

1995
Lindane cytotoxicity in cultured neocortical neurons is ameliorated by GABA and flunitrazepam.
    Journal of neuroscience research, 1994, Dec-15, Volume: 39, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Chlorine; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Mice; Neurons; Potassium; Receptors, GABA

1994
Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system.
    Epilepsia, 1995, Volume: 36, Issue:10

    Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Chloride Channels; Chlorine; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Furans; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isomerism; Male; Mice; Mice, Inbred C57BL; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1995
Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype.
    British journal of pharmacology, 1995, Volume: 115, Issue:3

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Chlorides; Cloning, Molecular; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Ion Channels; Kidney; Kinetics; Patch-Clamp Techniques; Picrotoxin; Rats; Receptors, GABA-A

1995
Chronic neurosteroid treatment produces functional heterologous uncoupling at the gamma-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons.
    Molecular pharmacology, 1995, Volume: 47, Issue:3

    Topics: Androstanes; Animals; Azasteroids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chlorides; Chlorine; Convulsants; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Pregnanolone; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Time Factors; Tritium

1995
Selective actions of certain neuroactive pregnanediols at the gamma-aminobutyric acid type A receptor complex in rat brain.
    Molecular pharmacology, 1995, Volume: 47, Issue:2

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Pregnanediol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1995
Behavioral and neurochemical changes caused by repeated ethanol and cocaine administration.
    Psychopharmacology, 1993, Volume: 110, Issue:4

    Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Convulsants; Dopamine; Ethanol; gamma-Aminobutyric Acid; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-A; Spiperone; Substantia Nigra

1993
Age-related changes of GABA-activated chloride channel properties in brain cortex synaptic plasma membrane: evidence for phospholipase involvement.
    Journal of neurochemistry, 1994, Volume: 63, Issue:4

    Topics: Aging; Animals; Arachidonic Acid; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Chlorides; Convulsants; Diglycerides; gamma-Aminobutyric Acid; Kinetics; Muscimol; Phospholipases; Picrotoxin; Rats; Rats, Wistar; Sulfur Radioisotopes; Synaptic Membranes; Synaptosomes

1994
Effects of GABA and various allosteric ligands on TBPS binding to cloned rat GABA(A) receptor subtypes.
    British journal of pharmacology, 1994, Volume: 112, Issue:4

    Topics: Allosteric Regulation; Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; gamma-Aminobutyric Acid; Ligands; Rats; Receptors, GABA-A; Spodoptera; Zinc

1994
Allosteric modulation of [35S]TBPS-binding in the cerebral cortex of the rat during postnatal development.
    Brain research. Developmental brain research, 1994, Jul-15, Volume: 80, Issue:1-2

    Topics: Aging; Allosteric Regulation; Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism; Sulfur Radioisotopes

1994
Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Jun-21, Volume: 91, Issue:13

    Topics: Amino Acid Sequence; Animals; Base Sequence; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Convulsants; DNA Primers; DNA, Complementary; Drosophila melanogaster; Female; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression; Macromolecular Substances; Molecular Sequence Data; Muscimol; Oocytes; Pentobarbital; Picrotoxin; Polymerase Chain Reaction; Receptors, GABA; Receptors, GABA-A; Transcription, Genetic; Xenopus laevis

1994
Effects of propofol, pentobarbital and alphaxalone on t-[35S]butylbicyclophosphorothionate binding in rat cerebral cortex.
    European journal of pharmacology, 1994, Apr-15, Volume: 267, Issue:2

    Topics: Anesthetics; Animals; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes

1994
Mono N-aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: implications for psychiatry.
    Neurochemical research, 1993, Volume: 18, Issue:7

    Topics: Androstanes; Animals; Antidepressive Agents; Antipsychotic Agents; Azasteroids; Bicarbonates; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Ethylenediamines; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

1993
Chronic benzodiazepine agonist treatment produces functional uncoupling of the gamma-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons.
    Molecular pharmacology, 1994, Volume: 45, Issue:4

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloride Channels; Female; Flumazenil; Flurazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channel Gating; Macromolecular Substances; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Receptors, GABA; Receptors, GABA-A

1994
GABAergic and dopaminergic transmission in the brain of Roman high-avoidance and Roman low-avoidance rats.
    Brain research, 1994, Feb-28, Volume: 638, Issue:1-2

    Topics: Amygdala; Animals; Avoidance Learning; Benzazepines; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chlorides; Convulsants; Corpus Striatum; Dopamine; Emotions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Nucleus Accumbens; Organ Specificity; Prefrontal Cortex; Rats; Rats, Mutant Strains; Receptors, Dopamine D1; Species Specificity; Synaptic Transmission

1994
Modulation of 35S-TBPS binding by GABAergic drugs in the cerebral cortex of newborn and adult rats.
    Brain research bulletin, 1993, Volume: 32, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Diazepam; gamma-Aminobutyric Acid; Kinetics; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes

1993
Interconvertible kinetic states of t-butylbicycloorthobenzoate binding sites of the gamma-aminobutyric acidA ionophores.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Fractionation; Cell Membrane; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; Intracellular Membranes; Kinetics; Ligands; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Synaptosomes; Tritium

1993
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Antagonists; Receptors, GABA; Receptors, Purinergic P1; Seizures; Sulfur Radioisotopes; Synaptic Transmission; Tritium; Xanthines

1993
Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
    European journal of pharmacology, 1993, Sep-15, Volume: 247, Issue:1

    Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cerebellum; Cloning, Molecular; Convulsants; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Humans; Kidney; Muscimol; Mutation; Picrotoxin; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection

1993
Bicuculline-produced regional differences in the modulation of 35S-TBPS binding by GABA, pentobarbital and diazepam in mouse cerebellum and cortex.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Receptors, GABA-A

1993
Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes.
    Journal of medicinal chemistry, 1993, Mar-05, Volume: 36, Issue:5

    Topics: Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; gamma-Aminobutyric Acid; Indenes; Magnetic Resonance Spectroscopy; Molecular Structure; Phenanthrenes; Receptors, GABA-A; Structure-Activity Relationship

1993
The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:3

    Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors

1993
Regional gamma-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35S]thionate binding depends on gamma-aminobutyric acidA receptor alpha subunit.
    Molecular pharmacology, 1993, Volume: 44, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Convulsants; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins

1993
Effects of chronic pentobarbital treatment on the GABAA receptor complex in mammalian cortical neurons.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:3

    Topics: Animals; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Neurons; Pentobarbital; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Tritium

1995
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
    Biochemical pharmacology, 1996, Jun-14, Volume: 51, Issue:11

    Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium

1996
Kinetics of tert-[35S]butylbicyclophosphorothionate binding in the cerebral cortex of newborn and adult rats: effects of GABA and receptor desensitization.
    Journal of neurochemistry, 1996, Volume: 67, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Female; gamma-Aminobutyric Acid; Kinetics; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; Receptors, GABA; Sensitivity and Specificity; Sulfur Radioisotopes

1996
Taurine allosterically inhibits binding of [35S]-t-butylbicyclophosphorothionate (TBPS) to rat brain synaptic membranes.
    Neuropharmacology, 1995, Volume: 34, Issue:12

    Topics: Allosteric Regulation; Animals; Bicuculline; Binding Sites; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes; Synaptic Membranes; Taurine

1995
Effects of the androgenic/anabolic steroid stanozolol on GABAA receptor function: GABA-stimulated 36Cl- influx and [35S] TBPS binding.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 279, Issue:1

    Topics: Anabolic Agents; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stanozolol

1996
Clozapine and some other antipsychotic drugs may preferentially block the same subset of GABA(A) receptors.
    Neurochemical research, 1997, Volume: 22, Issue:2

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Benzodiazepinones; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Clozapine; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Naloxone; Prosencephalon; Rats; Receptors, GABA

1997
Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit.
    Neuropharmacology, 1996, Volume: 35, Issue:12

    Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; Diazepam; DNA, Complementary; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Macromolecular Substances; Male; Membrane Potentials; Oocytes; Picrotoxin; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Triazoles; Xenopus laevis

1996
Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.
    British journal of pharmacology, 1997, Volume: 120, Issue:5

    Topics: Anesthetics, General; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; gamma-Aminobutyric Acid; Humans; Pentobarbital; Pregnanolone; Propofol; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sulfur Radioisotopes

1997
Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebellum; Cerebral Cortex; Chlorides; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Male; Mice; Mice, Inbred C57BL; Picrotoxin; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1997
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
    Molecular pharmacology, 1997, Volume: 52, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc

1997
Pharmacology of skeletal muscle GABA-gated chloride channels in the cockroach Periplaneta americana.
    The Journal of experimental biology, 1997, Volume: 200, Issue:Pt 23

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isonicotinic Acids; Male; Motor Neurons; Muscle, Skeletal; Periplaneta; Picrotoxin; Receptors, GABA; Sesterterpenes

1997
Clathrin-coated vesicles from bovine brain contain uncoupled GABAA receptors.
    Brain research, 1997, Nov-21, Volume: 776, Issue:1-2

    Topics: Allosteric Site; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chloride Channels; Clathrin; Coated Vesicles; Convulsants; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Ligands; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Membranes; Tritium

1997
Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Action Potentials; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Epilepsy, Absence; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Pentobarbital; Pregnanediones; Rats; Rats, Sprague-Dawley; Sulfur Radioisotopes; Thalamic Nuclei

1998
Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes.
    European journal of pharmacology, 1999, Feb-12, Volume: 367, Issue:1

    Topics: Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Lanthanum; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mutation; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles

1999
Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain.
    Psychoneuroendocrinology, 1999, Volume: 24, Issue:3

    Topics: Adrenalectomy; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corticotropin-Releasing Hormone; Electroshock; gamma-Aminobutyric Acid; Male; Orchiectomy; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Physiological

1999
Clozapine's antipsychotic effects do not depend on blockade of 5-HT3 receptors.
    Neurochemical research, 1999, Volume: 24, Issue:5

    Topics: Animals; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Drug Interactions; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Ondansetron; Quinacrine; Quipazine; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Sulfur Radioisotopes; Tropanes

1999
GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons.
    Journal of neurophysiology, 1999, Volume: 82, Issue:1

    Topics: Adult; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chloride Channels; Convulsants; Crotonates; Embryo, Mammalian; gamma-Aminobutyric Acid; Ganglia, Spinal; Glycine; Humans; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Potassium Channels; Pregnanediones; Receptors, GABA-A; Taurine

1999
Biphasic modulation of GABA(A) receptor binding by steroids suggests functional correlates.
    Neurochemical research, 1999, Volume: 24, Issue:11

    Topics: Androstanes; Anesthetics; Animals; Azasteroids; Baculoviridae; Bicuculline; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Pregnanediones; Rats; Receptors, GABA-A; Recombinant Proteins; Spodoptera; Steroids; Sulfur Radioisotopes

1999
Modulation by bicuculline and penicillin of the block by t-butyl-bicyclo-phosphorothionate (TBPS) of GABA(A)-receptor mediated Cl(-)-current responses in rat striatal neurones.
    British journal of pharmacology, 2000, Volume: 129, Issue:2

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chloride Channels; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Neostriatum; Neurons; Patch-Clamp Techniques; Penicillins; Rats; Receptors, GABA-A

2000
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Fetus; Frontal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Sheep; Sulfur Radioisotopes

2000
Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Behavior, Animal; Bicuculline; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dose-Response Relationship, Drug; Drinking Behavior; Flumazenil; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Isoquinolines; Male; Membrane Potentials; Membranes; Neurons; Oxazines; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Synaptic Transmission; Tetrodotoxin; Tranquilizing Agents

2000
Heterogeneity of hippocampal GABA(A) receptors: regulation by corticosterone.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1

    Topics: Allosteric Regulation; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Corticosterone; Dendrites; Desoxycorticosterone; Drug Implants; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2001
Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions.
    Brain research. Molecular brain research, 2001, Jan-31, Volume: 86, Issue:1-2

    Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Chickens; Convulsants; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes; Thalamus; Tritium

2001
Magnesium potentiation of the function of native and recombinant GABA(A) receptors.
    Neuroreport, 2001, Jul-20, Volume: 12, Issue:10

    Topics: Action Potentials; Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; gamma-Aminobutyric Acid; Magnesium Chloride; Male; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis

2001
Cation modulation of GABA(A) receptors in brain sections of AT and ANT rats.
    Alcohol (Fayetteville, N.Y.), 2001, Volume: 25, Issue:2

    Topics: Alcohol Drinking; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cations; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Lanthanum; Magnesium Chloride; Male; Rats; Receptors, GABA-A; Species Specificity

2001
Modulation Of [35S]-tert-butylbicyclophosphorothionate binding by somatostatin in rat hypothalamus.
    Clinical and experimental pharmacology & physiology, 2002, Volume: 29, Issue:4

    Topics: Animals; Bicuculline; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Somatostatin; Sulfur Radioisotopes

2002
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.
    The Journal of biological chemistry, 2003, Apr-11, Volume: 278, Issue:15

    Topics: Affinity Labels; Animals; Aziridines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Female; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Muscimol; Oocytes; Porins; Pregnanolone; Rats; Recombinant Proteins; Steroids; Telencephalon; Transfection; Voltage-Dependent Anion Channel 1; Voltage-Dependent Anion Channels; Xenopus laevis

2003
Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Female; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Oocytes; Oxytocin; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Pregnancy; Pregnanolone; Protein Kinase C; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Supraoptic Nucleus; Transfection; Xenopus

2003
Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABA(A) receptor.
    Biochemical pharmacology, 2005, Nov-01, Volume: 70, Issue:9

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Glucosides; Male; Mannose; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Salicylates; Structure-Activity Relationship; Sulfur Radioisotopes

2005
Role of GABAergic antagonism in the neuroprotective effects of bilobalide.
    Brain research, 2007, Jan-12, Volume: 1128, Issue:1

    Topics: Animals; Area Under Curve; Bicuculline; Brain Edema; Bridged Bicyclo Compounds, Heterocyclic; Choline; Cyclopentanes; Drug Interactions; Excitatory Amino Acid Agonists; Furans; GABA Antagonists; gamma-Aminobutyric Acid; Ginkgolides; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neuroprotective Agents; Nonlinear Dynamics; Picrotoxin; Rats; Rats, Sprague-Dawley; Synaptosomes

2007
Characterization of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding to GABAA receptors in postmortem human brain.
    British journal of pharmacology, 2007, Volume: 150, Issue:8

    Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Convulsants; GABA Antagonists; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Kinetics; Ligands; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Time Factors

2007
Alterations in GABA(A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods.
    Synapse (New York, N.Y.), 2007, Volume: 61, Issue:6

    Topics: Adaptation, Physiological; Aging; Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Corpus Striatum; Denervation; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Male; Neural Pathways; Neuronal Plasticity; Prefrontal Cortex; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Schizophrenia; Up-Regulation

2007
Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic alpha6beta GABA(A) receptors.
    Journal of neurochemistry, 2008, Volume: 105, Issue:2

    Topics: Animals; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dark Adaptation; Dose-Response Relationship, Drug; Exploratory Behavior; Female; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Isoxazoles; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Binding; Protein Subunits; Reaction Time; Receptors, GABA-A; Reflex; Thy-1 Antigens; Transfection

2008
GABA released from cultured cortical neurons influences the modulation of t-[(35)S]butylbicyclophosphorothionate binding at the GABAA receptor Effects of thymol.
    European journal of pharmacology, 2008, Dec-14, Volume: 600, Issue:1-3

    Topics: Allosteric Regulation; Anesthetics, Intravenous; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Survival; Cells, Cultured; Cerebral Cortex; Chlorides; gamma-Aminobutyric Acid; Mice; Propofol; Receptors, GABA-A; Thymol

2008
Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits.
    Neurochemistry international, 2009, Volume: 55, Issue:6

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Protein Subunits; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes

2009
Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.
    The Journal of physiology, 2012, Jan-01, Volume: 590, Issue:1

    Topics: Bicuculline; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; HEK293 Cells; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Receptors, Serotonin, 5-HT3

2012
Characterization of the picrotoxin site of GABAA receptors.
    Current protocols in pharmacology, 2001, Volume: Chapter 1

    Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Kinetics; Membranes; Nitriles; Picrotoxin; Radioligand Assay; Rats; Receptors, GABA-A; Specimen Handling; Statistics as Topic; Sulfur Radioisotopes

2001
Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist.
    Neuroscience, 2014, Jan-03, Volume: 256

    Topics: Acetylcholine; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; GABA Antagonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Microdialysis; Naphthyridines; Oxadiazoles; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Isotopes

2014