Page last updated: 2024-09-02

tert-butylbicyclo-2-benzoate and gamma-aminobutyric acid

tert-butylbicyclo-2-benzoate has been researched along with gamma-aminobutyric acid in 24 studies

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]

Compound Research Comparison

Studies
(tert-butylbicyclo-2-benzoate)
Trials
(tert-butylbicyclo-2-benzoate)
Recent Studies (post-2010)
(tert-butylbicyclo-2-benzoate)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
520240,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomytert-butylbicyclo-2-benzoate (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19906 (25.00)18.7374
1990's14 (58.33)18.2507
2000's4 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dirksen, R; Rodrigues de Miranda, JF; van Rijn, CM; Willems-van Bree, E1
Kuriyama, K; Ueha, T1
Pericić, D; Tvrdeić, A1
Dodd, PR; Gundlach, AL; Harper, PA; Johnston, GA; Lummis, SC1
Casida, JE; Palmer, CJ1
Kovács, I; Maksay, G; Simonyi, M1
de Costa, BR; Lewin, AH; Rice, KC; Skolnick, P1
Casida, JE; Gee, KW; Lawrence, LJ; Palmer, CJ; Wang, X; Yamamura, HI1
Fishman, BE; Gianutsos, G; McGinley, PA1
Mcewen, BS; O'Connor, LH1
Akaike, N; Katayama, N; Ozoe, Y; Tokutomi, N1
Dirksen, R; Maksay, G; van Rijn, CM; Willems-van Bree, E1
Baubichon, D; Blanchet, G; Carpentier, P; Collet, A; Lallement, G; Pernot-Marino, I1
Golovko, AI; Kliuntina, TV; Nikolaeva, TV; Pluzhnikov, NN; Sofronov, GA1
Maksay, G; van Rijn, CM1
Casida, JE; Goeldner, MP; Hawkinson, JE; Kapfer, I1
Golovko, AI; Kliuntina, TV; Sofronov, GA1
Albin, RL; Caspary, DM; Milbrandt, JC; Turgeon, SM1
Besnard, F; Jazvinsćak, M; Mirković, K; Pericić, D1
Dirksen, R; Rodrigues de Miranda, JF; Van Rijn, CM; Willems-van Bree, E; Zwart, JP1
Cairns, D; Chazot, PL; Duggan, C; Lees, G; Rezai, N1
van Rijn, CM; Willems-van Bree, E1
Jembrek, MJ; Lazić, J; Pericić, D; Rajcan, I; Strac, DS1
Mehta, AK; Ticku, MK1

Reviews

1 review(s) available for tert-butylbicyclo-2-benzoate and gamma-aminobutyric acid

ArticleYear
2,6,7-Trioxabicyclo[2.2.2]octanes: chemistry, toxicology and action at the GABA-gated chloride channel.
    Advances in biochemical psychopharmacology, 1988, Volume: 45

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorides; Convulsants; gamma-Aminobutyric Acid; Hydrolysis; Insecta; Ion Channels; Ligands; Structure-Activity Relationship

1988

Other Studies

23 other study(ies) available for tert-butylbicyclo-2-benzoate and gamma-aminobutyric acid

ArticleYear
The GABAA receptor complex in relation to epilepsy. Reversal of [3H]TBOB inhibition: a prediction of proconvulsive properties?
    Epilepsy research, 1992, Volume: 12, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Epilepsy; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Membranes; Models, Biological; Rats; Rats, Wistar; Receptors, GABA-A

1992
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
    Alcohol and alcoholism (Oxford, Oxfordshire), 1992, Volume: 27, Issue:4

    Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Neurons; Radioligand Assay; Receptors, GABA-A; Synaptic Membranes; Synaptic Vesicles

1992
Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore.
    European journal of pharmacology, 1991, Sep-04, Volume: 202, Issue:1

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dihydroergotamine; Dihydroergotoxine; Ergot Alkaloids; Ergotamines; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Ionophores; Mice; Mice, Inbred CBA; Receptors, GABA-A; Synaptosomes

1991
Increased gamma-aminobutyric acid receptor function in the cerebral cortex of myoclonic calves with an hereditary deficit in glycine/strychnine receptors.
    Journal of neurochemistry, 1990, Volume: 55, Issue:2

    Topics: Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Diazepam; Female; gamma-Aminobutyric Acid; Ligands; Male; Membrane Proteins; Muscimol; Myoclonus; Radioisotopes; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Synaptic Membranes

1990
Inhibition of high-affinity synaptosomal uptake of gamma-aminobutyric acid by a bicyclo-heptane derivative.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:3

    Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Camphanes; Carbolines; Cerebral Cortex; Diazepam; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Synaptic Membranes; Synaptosomes

1989
meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore.
    Molecular pharmacology, 1989, Volume: 35, Issue:2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chloride Channels; Chlorides; gamma-Aminobutyric Acid; In Vitro Techniques; Isothiocyanates; Ligands; Male; Membrane Proteins; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiocyanates

1989
t-[3H]butylbicycloorthobenzoate: new radioligand probe for the gamma-aminobutyric acid-regulated chloride ionophore.
    Journal of neurochemistry, 1985, Volume: 45, Issue:3

    Topics: Androstanes; Animals; Azasteroids; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chemical Phenomena; Chemistry; Chlorides; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Ionophores; Kinetics; Male; Rats; Receptors, GABA-A; Temperature

1985
Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity.
    Toxicology, 1987, Volume: 45, Issue:2

    Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Corn Oil; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Lethal Dose 50; Male; Manganese; Mice; Organometallic Compounds; Propylene Glycol; Propylene Glycols; Seizures

1987
Autoradiographic localization of GABA-regulated chloride ionophore binding sites using [3H]t-butylbicycloorthobenzoate.
    European journal of pharmacology, 1986, Jan-14, Volume: 120, Issue:1

    Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Female; gamma-Aminobutyric Acid; Rats

1986
Effects of lindane (gamma-BHC) and related convulsants on GABAA receptor-operated chloride channels in frog dorsal root ganglion neurons.
    Brain research, 1994, Apr-18, Volume: 643, Issue:1-2

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Convulsants; Dose-Response Relationship, Drug; Electrophysiology; gamma-Aminobutyric Acid; Ganglia, Spinal; Hexachlorocyclohexane; In Vitro Techniques; Membrane Potentials; Neurons; Picrotoxin; Rana catesbeiana; Receptors, GABA-A

1994
Diazepam biphasically modulates [3H]TBOB binding to the convulsant site of the GABAA receptor complex.
    Journal of receptor and signal transduction research, 1995, Volume: 15, Issue:6

    Topics: Animals; Bicuculline; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A

1995
Transient impairment of the gabaergic function during initiation of soman-induced seizures.
    Brain research, 1993, Dec-03, Volume: 629, Issue:2

    Topics: Animals; Autoradiography; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Diazepam; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Microdialysis; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Seizures; Soman

1993
[The effect of triorthocresyl phosphate on the toxicity of GABA-lytics for mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:10

    Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carboxylic Ester Hydrolases; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Male; Mice; Picrotoxin; Synaptic Membranes; Tritolyl Phosphates

1993
Interconvertible kinetic states of t-butylbicycloorthobenzoate binding sites of the gamma-aminobutyric acidA ionophores.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicuculline; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Fractionation; Cell Membrane; Cerebral Cortex; Convulsants; gamma-Aminobutyric Acid; Intracellular Membranes; Kinetics; Ligands; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Synaptosomes; Tritium

1993
Photoactivatable 2-(4'-azidotetrafluorophenyl)-5-tert-butyl-1,3-dithiane-bis- sulfone and related compounds as candidate irreversible probes for the GABA-gated chloride channels.
    Journal of medicinal chemistry, 1994, Jan-07, Volume: 37, Issue:1

    Topics: Affinity Labels; Animals; Azides; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Cerebral Cortex; Chloride Channels; Convulsants; gamma-Aminobutyric Acid; Ion Channel Gating; Light; Photochemistry; Sulfones

1994
[The effect of 3-mercaptopropionic acid on the toxicity of GABA-lytics for mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:11

    Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Ligands; Male; Mice; Picrotoxin; Synaptic Membranes; Time Factors

1993
GABAA receptor binding in the aging rat inferior colliculus.
    Neuroscience, 1996, Volume: 73, Issue:2

    Topics: Aged; Aging; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Inferior Colliculi; Ligands; Muscimol; Picrotoxin; Rats; Rats, Inbred F344; Receptors, GABA-A; Tritium

1996
[3H]t-butylbicycloorthobenzoate binding to recombinant alpha1beta2gamma2s GABA(A) receptor.
    European journal of pharmacology, 1998, Oct-30, Volume: 360, Issue:1

    Topics: Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Picrotoxin; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins; Thiopental; Tritium

1998
A molecular model for the synergic interaction between gamma-aminobutyric acid and general anaesthetics.
    European journal of pharmacology, 1999, Apr-29, Volume: 371, Issue:2-3

    Topics: Allosteric Site; Anesthetics, General; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Models, Molecular; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A

1999
Modulation of [3H] TBOB binding to the rodent GABAA receptor by simple disaccharides.
    Biochemical pharmacology, 2003, Feb-15, Volume: 65, Issue:4

    Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebellum; Drug Interactions; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Glycosylation; Lactose; Male; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA-A; Tritium

2003
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex.
    European journal of pharmacology, 2003, Mar-19, Volume: 464, Issue:2-3

    Topics: Animals; Anticonvulsants; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Kinetics; Models, Biological; Phenylenediamines; Rats; Rats, Wistar; Receptors, GABA-A; Tritium

2003
Chronic exposure of cells expressing recombinant GABAA receptors to benzodiazepine antagonist flumazenil enhances the maximum number of benzodiazepine binding sites.
    Life sciences, 2004, Dec-03, Volume: 76, Issue:3

    Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Flumazenil; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Receptors, GABA-A; Recombinant Proteins; Tritium

2004
Characterization of the picrotoxin site of GABAA receptors.
    Current protocols in pharmacology, 2001, Volume: Chapter 1

    Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Kinetics; Membranes; Nitriles; Picrotoxin; Radioligand Assay; Rats; Receptors, GABA-A; Specimen Handling; Statistics as Topic; Sulfur Radioisotopes

2001